Compounds > anoplin
Page last updated: 2024-11-12

anoplin

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Description

anoplin: an antimicrobial peptide from the venom of the solitary wasp Anoplius samariensis; peptide sequence in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10307332
CHEMBL ID2396875
MeSH IDM0409752

Synonyms (6)

Synonym
CHEMBL2396875
anoplin
321352-67-4
anoplin (gllkriktll-nh2)
RS-2038
gly-leu-leu-lys-arg-ile-lys-thr-leu-leu-nh2

Research Excerpts

Overview

Anoplin is a recently discovered antimicrobial peptide (AMP) isolated from the venom sac of the spider wasp Anoplius samariensis. It is one of the shortest α-helical AMP found naturally to date consisting of only ten amino acids.

ExcerptReferenceRelevance
"Anoplin is a recently discovered antimicrobial peptide (AMP) isolated from the venom sac of the spider wasp Anoplius samariensis, and it is one of the shortest α-helical AMP found naturally to date consisting of only ten amino acids. "( Novel cytotoxic exhibition mode of antimicrobial peptide anoplin in MEL cells, the cell line of murine Friend leukemia virus-induced leukemic cells.
Chen, W; Fu, CY; Jin, YT; Zhang, SF; Zhao, FK; Zhu, LN, 2013)		2.08
"Anoplin is a short natural cationic antimicrobial peptide which is derived from the venom sac of the solitary wasp, Anoplius samariensis. "( Synthesis and biological activity of lipophilic analogs of the cationic antimicrobial active peptide anoplin.
Chionis, K; Koukkou, AI; Krikorian, D; Panou-Pomonis, E; Sakarellos-Daitsiotis, M, 2016)		2.09
"Anoplin is a decapeptide amide, GLLKRIKTLL-NH2 derived from the venom sac of the solitary spider wasp, Anoplius samariensis. "( Structure-activity relationship study of anoplin.
Doisy, X; Hansen, PR; Ifrah, D; Ryge, TS, 2005)		2.04

Compound-Compound Interactions

ExcerptReferenceRelevance
" In vitro and in vivo studies were conducted to investigate the antitumor mechanism of A3@GMH in combination with photothermal therapy(PTT) through inducing immunogenic cell death(ICD) in 4T1 cells."( [Stapled anoplin peptide combined with photothermal therapy enhances oncolytic immunotherapy of triple-negative breast cancer].
Gao, WD; Lin, JY; Liu, XX; Lu, SX; Luan, X; Song, YX; Wu, Y; Yang, T; Zhang, WD; Zhang, XK, 2023)		1.33
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (109)

Assay IDTitleYearJournalArticle
AID1565595Antibacterial activity against methicillin-resistant Staphylococcus aureus 936 after 18 hrs by CLSI based broth microdilution method2019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1565700Ratio of antibacterial activity against Staphylococcus aureus ATCC 25923 in presence of KCl to antibacterial activity against Staphylococcus aureus ATCC 259232019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1765579Antibacterial activity against Klebsiella pneumoniae ATCC 700603 incubated for 18 hrs by CLSI based broth dilution method2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1765601Antibacterial activity against Klebsiella pneumoniae ATCC 700603 incubated with 0.2 to 0.02 ug/ml chymotrypsin for 6 hrs followed by bacterial addition and measured after 18 hrs by CLSI based broth dilution method2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1806980Cytotoxicity against mouse 4T1 cells assessed as disruption of cells by measuring increase in red fluorescence at 10 uM measured up to 3 hrs by calcein-AM and PI dual staining based live/dead cell viability assay2021Journal of medicinal chemistry, 05-13, Volume: 64, Issue:9
Stapled Wasp Venom-Derived Oncolytic Peptides with Side Chains Induce Rapid Membrane Lysis and Prolonged Immune Responses in Melanoma.
AID1765595Selectivity ratio of MHC10 for BALB/C mouse erythrocytes to MIC for gram-negative bacteria2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1565652Potentiation of rifampicin-induced antibacterial activity against Pseudomonas aeruginosa ATCC 27853 assessed as FICI after 18 hrs by checker board assay2019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1565599Selectivity index, ratio of MHC10 for human RBC to geometric mean of peptide MIC for gram positive bacteria2019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1565699Ratio of antibacterial activity against Staphylococcus aureus ATCC 25923 in presence of NaCl to antibacterial activity against Staphylococcus aureus ATCC 259232019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1765621Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 at 0.5 to 4 times MIC incubated for 24 hrs by crystal violet staining based assay2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1765602Antibacterial activity against Staphylococcus aureus ATCC 25923 incubated with 0.2 to 0.02 ug/ml trypsin for 6 hrs followed by bacterial addition and measured after 18 hrs by CLSI based broth dilution method2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1565596Antibacterial activity against Bacillus subtilis ATCC 23857 after 18 hrs by CLSI based broth microdilution method2019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1565647Potentiation of polymyxin B-induced antibacterial activity against Escherichia coli ATCC 25922 assessed as FICI after 18 hrs by checker board assay2019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1765643Synergistic antibacterial activity against Escherichia coli ATCC 25922 at 2 times MIC incubated for 18 to 24 hrs in presence of 2 times MIC of polymyxin B by broth microdilution assay based checkerboard assay2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1565649Potentiation of polymyxin B-induced antibacterial activity against Pseudomonas aeruginosa ATCC 27853 assessed as FICI after 18 hrs by checker board assay2019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1565623Antibacterial activity against Staphylococcus aureus ATCC 25923 after 18 hrs in presence of NaCl by CLSI based broth microdilution method (Rvb = 64 microM)2019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1565635Antibacterial activity against Staphylococcus aureus ATCC 25923 after 18 hrs in presence of MgCl2 by CLSI based broth microdilution method (Rvb = 64 microM)2019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1765599Stability in BALB/C mouse serum measured up to 1440 mins by HPLC analysis2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1765600Stability in BALB/C mouse serum assessed as compound degradation time measured up to 1440 mins by HPLC analysis2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1565675Antimicrobial activity against Escherichia coli ATCC 25922 preincubated for 6 hrs in presence of 10% mouse serum and measured after 18 hrs by CLSI-based broth microdilution assay (Rvb = 64 microM)2019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1565600Selectivity index, ratio of MHC10 for human RBC to geometric mean of peptide MIC for gram negative bacteria2019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1565607Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs in presence of NaCl by CLSI based broth microdilution method (Rvb = 64 microM)2019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1765639Disruption of bacterial cell membrane in Staphylococcus aureus ATCC 25923 assessed as increase in PI uptake incubated for 30 to 120 mins by FACS flow cytometry2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1765646Synergistic antibacterial activity against Klebsiella pneumoniae ATCC 700603 at 2 times MIC incubated for 18 to 24 hrs in presence of 2 times MIC of polymyxin B by broth microdilution assay based checkerboard assay2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1565593Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 18 hrs by CLSI based broth microdilution method2019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1565679Ratio of MIC for Escherichia coli ATCC 25922 preincubated for 1 hr in presence of 10% mouse serum and measured after 18 hrs to MIC for antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs2019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1765582Cytotoxicity against human glomerular mesangial cells incubated for 12 hrs by MTT assay2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1565697Ratio of antibacterial activity against Escherichia coli ATCC 25922 in presence of MgCl2 to antibacterial activity against Escherichia coli ATCC 259222019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1765574Antibacterial activity against Bacillus subtilis ATCC 23857 incubated for 18 hrs by CLSI based broth dilution method2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1806991Toxicity in B16-F10 tumor bearing C57 mouse assessed as change in body weight at 1 mg, IT administered once daily for 3 consecutive days starting from day 5 post inoculation2021Journal of medicinal chemistry, 05-13, Volume: 64, Issue:9
Stapled Wasp Venom-Derived Oncolytic Peptides with Side Chains Induce Rapid Membrane Lysis and Prolonged Immune Responses in Melanoma.
AID1806973Cytotoxicity against mouse 4T1 cells assessed as loss of membrane integrity by measuring increase in LDH release incubated for 24 hrs by LDH release assay2021Journal of medicinal chemistry, 05-13, Volume: 64, Issue:9
Stapled Wasp Venom-Derived Oncolytic Peptides with Side Chains Induce Rapid Membrane Lysis and Prolonged Immune Responses in Melanoma.
AID755923Antibacterial activity against Staphylococcus aureus ATCC 259923 assessed as growth inhibition after 24 hrs by broth microdilution method2013Bioorganic & medicinal chemistry letters, Jul-01, Volume: 23, Issue:13
Improving the biological activity of the antimicrobial peptide anoplin by membrane anchoring through a lipophilic amino acid derivative.
AID1806975Antiproliferative activity against mouse B16-F10 cells assessed as inhibition of cell growth measured after 24 hrs by Cell Counting Kit-8 assay2021Journal of medicinal chemistry, 05-13, Volume: 64, Issue:9
Stapled Wasp Venom-Derived Oncolytic Peptides with Side Chains Induce Rapid Membrane Lysis and Prolonged Immune Responses in Melanoma.
AID1565667Antimicrobial activity against Escherichia coli ATCC 25922 at 1 mM preincubated for 6 hrs in presence of 2 ug/ml chymotrypsin and measured after 18 hrs by microplate reader analysis2019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1765616Induction of inner membrane permeabilization in Klebsiella pneumoniae ATCC 700603using ONPG as substrate by spectroscopic method2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1806985Toxicity in 4T1 tumor bearing BALB/c mouse assessed as increase in body weight at 1 mg, IT administered once daily for 3 consecutive days starting from day 2 post inoculation2021Journal of medicinal chemistry, 05-13, Volume: 64, Issue:9
Stapled Wasp Venom-Derived Oncolytic Peptides with Side Chains Induce Rapid Membrane Lysis and Prolonged Immune Responses in Melanoma.
AID1765589Antibacterial activity against fungi incubated for 18 hrs by CLSI based broth dilution method2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1765642Synergistic antibacterial activity against Escherichia coli ATCC 25922 at 2 times MIC incubated for 18 to 24 hrs in presence of 2 times MIC of rifampicin by broth microdilution assay based checkerboard assay2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1765640Synergistic antibacterial activity against Pseudomonas aeruginosa ATCC 27853 at 2 times MIC incubated for 18 to 24 hrs in presence of 2 times MIC of rifampicin by broth microdilution assay based checkerboard assay2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1565591Antibacterial activity against Escherichia coli ATCC 43837 after 18 hrs by CLSI based broth microdilution method2019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1806999Antitumor activity against mouse B16-F10 cells implanted in BABL/c mouse assessed as increase in infiltration of CD8 positive T cells into tumors at 1 mg, IT administered once daily for 3 consecutive days starting from day 5 post inoculation and measured 2021Journal of medicinal chemistry, 05-13, Volume: 64, Issue:9
Stapled Wasp Venom-Derived Oncolytic Peptides with Side Chains Induce Rapid Membrane Lysis and Prolonged Immune Responses in Melanoma.
AID1806974Antiproliferative activity against triple-negative mouse 4T1 cells assessed as inhibition of cell growth measured after 24 hrs by Cell Counting Kit-8 assay2021Journal of medicinal chemistry, 05-13, Volume: 64, Issue:9
Stapled Wasp Venom-Derived Oncolytic Peptides with Side Chains Induce Rapid Membrane Lysis and Prolonged Immune Responses in Melanoma.
AID1806996Antitumor activity against mouse 4T1 cells implanted in BABL/c mouse assessed as increase in infiltration of CD4 positive T lymphocytes in tumors at 1 mg, IT administered once daily for 3 consecutive days starting from day 2 post inoculation and measured 2021Journal of medicinal chemistry, 05-13, Volume: 64, Issue:9
Stapled Wasp Venom-Derived Oncolytic Peptides with Side Chains Induce Rapid Membrane Lysis and Prolonged Immune Responses in Melanoma.
AID1565590Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs by CLSI based broth microdilution method2019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1565684Disruption of membrane integrity in Escherichia coli ATCC 25922 assessed as membrane damage by measuring PI fluorescence at 4 times of MIC incubated for 1 hr by PI dye based flow cytometric analysis (Rvb = 1.35%)2019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID755921Therapeutic index, ratio of EC50 for hemolysis of sheep erythrocytes to MIC for Escherichia coli ATCC 87392013Bioorganic & medicinal chemistry letters, Jul-01, Volume: 23, Issue:13
Improving the biological activity of the antimicrobial peptide anoplin by membrane anchoring through a lipophilic amino acid derivative.
AID755922Hemolytic activity in sheep erythrocytes after 1 hr2013Bioorganic & medicinal chemistry letters, Jul-01, Volume: 23, Issue:13
Improving the biological activity of the antimicrobial peptide anoplin by membrane anchoring through a lipophilic amino acid derivative.
AID1565648Potentiation of polymyxin B-induced antibacterial activity against Klebsiella pneumoniae ATCC 700603 assessed as FICI after 18 hrs by checker board assay2019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1565698Ratio of antibacterial activity against Escherichia coli ATCC 25922 in presence of FeCl3 to antibacterial activity against Escherichia coli ATCC 259222019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1765641Synergistic antibacterial activity against Pseudomonas aeruginosa ATCC 27853 at 2 times MIC incubated for 18 to 24 hrs in presence of 2 times MIC of polymyxin B by broth microdilution assay based checkerboard assay2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1765590Selectivity ratio of MHC10 for BALB/C mouse erythrocytes to MIC for bacteria2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1565666Antimicrobial activity against Escherichia coli ATCC 25922 at 1 mM preincubated for 6 hrs in presence of 0.2 ug/ml trypsin and measured after 18 hrs by microplate reader analysis2019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1565685Disruption of membrane integrity in Escherichia coli ATCC 25922 assessed as membrane damage by measuring PI fluorescence at 2 times of MIC incubated for 1 hr by PI dye based flow cytometric analysis (Rvb = 1.35%)2019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1765603Antibacterial activity against Klebsiella pneumoniae ATCC 700603 incubated with 0.2 to 0.02 ug/ml trypsin for 6 hrs followed by bacterial addition and measured after 18 hrs by CLSI based broth dilution method2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1565629Antibacterial activity against Staphylococcus aureus ATCC 25923 after 18 hrs in presence of KCl by CLSI based broth microdilution method (Rvb = 64 microM)2019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1765580Antibacterial activity against Acinetobacter baumannii ATCC 19606 incubated for 18 hrs by CLSI based broth dilution method2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1565650Potentiation of rifampicin-induced antibacterial activity against Escherichia coli ATCC 25922 assessed as FICI after 18 hrs by checker board assay2019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID755919Induction of membrane lysis in DOPC large unilamellar vesicles model assessed as release of carboxyfluorescein at 50 ug/mL by fluorescence spectroscopic analysis relative to control2013Bioorganic & medicinal chemistry letters, Jul-01, Volume: 23, Issue:13
Improving the biological activity of the antimicrobial peptide anoplin by membrane anchoring through a lipophilic amino acid derivative.
AID1765577Antibacterial activity against Escherichia coli ATCC 25922 incubated for 18 hrs by CLSI based broth dilution method2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1565615Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs in presence of MgCl2 by CLSI based broth microdilution method (Rvb = 64 microM)2019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID755924Antibacterial activity against Escherichia coli ATCC 8739 assessed as growth inhibition after 24 hrs by broth microdilution method2013Bioorganic & medicinal chemistry letters, Jul-01, Volume: 23, Issue:13
Improving the biological activity of the antimicrobial peptide anoplin by membrane anchoring through a lipophilic amino acid derivative.
AID1565611Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs in presence of KCl by CLSI based broth microdilution method (Rvb = 64 microM)2019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1565705Induction of membrane disruption in Escherichia coli ATCC 25922 assessed as fracture in membrane at 4 times of MIC after 2 hrs by SEM analysis2019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1565704Antibiofilm activity against Staphylococcus aureus ATCC 25923 at 1 to 2 times of MIC after 24 hrs by crystal violet staining based assay2019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1806998Antitumor activity against mouse B16-F10 cells implanted in BABL/c mouse assessed as increase in infiltration of CD4 positive T cells into tumors at 1 mg, IT administered once daily for 3 consecutive days starting from day 5 post inoculation and measured 2021Journal of medicinal chemistry, 05-13, Volume: 64, Issue:9
Stapled Wasp Venom-Derived Oncolytic Peptides with Side Chains Induce Rapid Membrane Lysis and Prolonged Immune Responses in Melanoma.
AID1565689Induction of membrane disruption in Escherichia coli ATCC 25922 assessed as degeneration in membrane at 4 times of MIC after 2 hrs by SEM analysis2019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1565619Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs in presence of FeCl3 by CLSI based broth microdilution method (Rvb = 64 microM)2019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1765593Selectivity ratio of MHC10 for BALB/C mouse erythrocytes to MIC for gram positive bacteria2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1765633Disruption of membrane integrity in Staphylococcus aureus ATCC 25923 assessed as bacterial death at 1 times MIC measured within 0.5 hrs by scanning electron microscopy2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1565695Ratio of antibacterial activity against Escherichia coli ATCC 25922 in presence of NaCl to antibacterial activity against Escherichia coli ATCC 259222019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1765572Antibacterial activity against Staphylococcus aureus ATCC 25923 incubated with 0.2 to 0.02 ug/ml chymotrypsin for 6 hrs followed by bacterial addition and measured after 18 hrs by CLSI based broth dilution method2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1765597Bactericidal activity against Klebsiella pneumoniae 700603 at 2MIC by time-kill assay relative to control2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1565651Potentiation of rifampicin-induced antibacterial activity against Klebsiella pneumoniae ATCC 700603 assessed as FICI after 18 hrs by checker board assay2019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1765645Synergistic antibacterial activity against Klebsiella pneumoniae ATCC 700603 at 2 times MIC incubated for 18 to 24 hrs in presence of 2 times MIC of rifampicin by broth microdilution assay based checkerboard assay2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1565641Antibacterial activity against Staphylococcus aureus ATCC 25923 after 18 hrs in presence of FeCl3 by CLSI based broth microdilution method (Rvb = 64 microM)2019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID755918Induction of membrane lysis in DOPC/DOPG large unilamellar vesicles model assessed as release of carboxyfluorescein at 50 ug/mL by fluorescence spectroscopic analysis relative to control2013Bioorganic & medicinal chemistry letters, Jul-01, Volume: 23, Issue:13
Improving the biological activity of the antimicrobial peptide anoplin by membrane anchoring through a lipophilic amino acid derivative.
AID1765620Antibiofilm activity against Klebsiella pneumoniae ATCC 700603 at 2 to 4 times MIC incubated for 24 hrs by crystal violet staining based assay2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1765576Antibacterial activity against Staphylococcus epidermidis ATCC 12228 incubated for 18 hrs by CLSI based broth dilution method2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1765581Hemolytic activity in BALB/C mouse erythrocytes incubated for 1 hr by absorbance method2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1765617Induction of inner membrane permeabilization in Klebsiella pneumoniae ATCC 700603 at 0.5 to 4MIC using ONPG as substrate by spectroscopic method2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1765644Synergistic antibacterial activity against Escherichia coli ATCC 25922 at 2 times MIC incubated for 18 to 24 hrs in presence of 2 times MIC of gentamycin by broth microdilution assay based checkerboard assay2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1765596Bactericidal activity against Staphylococcus aureus ATCC 25923 at 2MIC by time-kill assay2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1565592Antibacterial activity against Klebsiella pneumoniae ATCC 700603 after 18 hrs by CLSI based broth microdilution method2019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1765622Antibacterial activity against Staphylococcus aureus ATCC 25923 at 0.5 to 1 times MIC incubated for 24 hrs by crystal violet staining based assay2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1765619Antibiofilm activity against Escherichia coli ATCC 25922 at 4 times MIC incubated for 24 hrs by crystal violet staining based assay2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1765647Synergistic antibacterial activity against Klebsiella pneumoniae ATCC 700603 at 2 times MIC incubated for 18 to 24 hrs in presence of 2 times MIC of gentamycin by broth microdilution assay based checkerboard assay2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1565696Ratio of antibacterial activity against Escherichia coli ATCC 25922 in presence of KCl to antibacterial activity against Escherichia coli ATCC 259222019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1765573Antibacterial activity against Staphylococcus aureus ATCC 25923 incubated for 18 hrs by CLSI based broth dilution method2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1806983Stability of the compound assessed as alpha chymotrypsin (unknown origin)-mediated proteolysis by measuring degradation half life at 1 mM measured up to 12 hrs by HPLC analysis2021Journal of medicinal chemistry, 05-13, Volume: 64, Issue:9
Stapled Wasp Venom-Derived Oncolytic Peptides with Side Chains Induce Rapid Membrane Lysis and Prolonged Immune Responses in Melanoma.
AID1565688Induction of membrane disruption in Escherichia coli ATCC 25922 assessed as corrugated membrane surface at 4 times of MIC after 2 hrs by SEM analysis2019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1565702Ratio of antibacterial activity against Staphylococcus aureus ATCC 25923 in presence of FeCl3 to antibacterial activity against Staphylococcus aureus ATCC 259232019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1565701Ratio of antibacterial activity against Staphylococcus aureus ATCC 25923 in presence of MgCl2 to antibacterial activity against Staphylococcus aureus ATCC 259232019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1765575Antibacterial activity against Enterococcus faecalis ATCC 29212 incubated for 18 hrs by CLSI based broth dilution method2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1565680Ratio of MIC for Escherichia coli ATCC 25922 preincubated for 6 hrs in presence of 10% mouse serum and measured after 18 hrs to MIC for antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs2019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1765588Antibacterial activity against bacteria incubated for 18 hrs by CLSI based broth dilution method2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1765594Antibacterial activity against Gram-negative bacteria incubated for 18 hrs by CLSI based broth dilution method2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1806997Antitumor activity against mouse 4T1 cells implanted in BABL/c mouse assessed as increase in infiltration of CD8 positive T lymphocytes in tumors at 1 mg, IT administered once daily for 3 consecutive days starting from day 2 post inoculation and measured 2021Journal of medicinal chemistry, 05-13, Volume: 64, Issue:9
Stapled Wasp Venom-Derived Oncolytic Peptides with Side Chains Induce Rapid Membrane Lysis and Prolonged Immune Responses in Melanoma.
AID1765578Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 incubated for 18 hrs by CLSI based broth dilution method2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1765591Selectivity ratio of MHC10 for BALB/C mouse erythrocytes to MIC for fungi2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1765583Disruption of membrane integrity in Staphylococcus aureus ATCC 25923 assessed as membrane shrinking at 1 times MIC measured within 0.5 hrs by scanning electron microscopy2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1765626Disruption of membrane integrity in Staphylococcus aureus ATCC 25923 assessed as membrane blebbing at 1 times MIC measured within 0.5 hrs by scanning electron microscopy2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1565597Hemolytic activity in human RBC measured after 1 hr by microplate reader analysis2019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID755920Therapeutic index, ratio of EC50 for hemolysis of sheep erythrocytes to MIC for Staphylococcus aureus ATCC 2599232013Bioorganic & medicinal chemistry letters, Jul-01, Volume: 23, Issue:13
Improving the biological activity of the antimicrobial peptide anoplin by membrane anchoring through a lipophilic amino acid derivative.
AID1565687Induction of membrane disruption in Escherichia coli ATCC 25922 assessed as rough membrane surface at 4 times of MIC after 2 hrs by SEM analysis2019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1565594Antibacterial activity against Staphylococcus aureus ATCC 25923 after 18 hrs by CLSI based broth microdilution method2019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1765592Antibacterial activity against Gram-positive bacteria incubated for 18 hrs by CLSI based broth dilution method2021Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1565671Antimicrobial activity against Escherichia coli ATCC 25922 preincubated for 1 hr in presence of 10% mouse serum and measured after 18 hrs by CLSI-based broth microdilution assay (Rvb = 64 microM)2019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1806989Antitumor activity against mouse B16-F10 cells implanted in C57 mouse assessed as reduction in tumor growth at 1 mg, IT administered once daily for 3 consecutive days starting from day 5 post inoculation2021Journal of medicinal chemistry, 05-13, Volume: 64, Issue:9
Stapled Wasp Venom-Derived Oncolytic Peptides with Side Chains Induce Rapid Membrane Lysis and Prolonged Immune Responses in Melanoma.
AID1565706Induction of ROS generation in Escherichia coli ATCC 259222019European journal of medicinal chemistry, Nov-15, Volume: 182Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (30)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (16.67)29.6817
2010's17 (56.67)24.3611
2020's8 (26.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 23.36

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index23.36 (24.57)
Research Supply Index3.43 (2.92)
Research Growth Index5.16 (4.65)
Search Engine Demand Index23.28 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (23.36)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (3.33%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other29 (96.67%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
ciprofloxacin
Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.. ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.		2.3110aminoquinoline;
cyclopropanes;
fluoroquinolone antibiotic;
N-arylpiperazine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone;
zwitterion		antibacterial drug;
antiinfective agent;
antimicrobial agent;
DNA synthesis inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
environmental contaminant;
topoisomerase IV inhibitor;
xenobiotic
erythrosine
Fluoresceins: A family of spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one derivatives. These are used as dyes, as indicators for various metals, and as fluorescent labels in immunoassays.		2.4720
penicillin g
Penicillin G: A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.. benzylpenicillin : A penicillin in which the substituent at position 6 of the penam ring is a phenylacetamido group.		2.6620penicillin allergen;
penicillin		antibacterial drug;
drug allergen;
epitope
kanamycin a
Kanamycin: Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components.. kanamycin : Kanamycin is a naturally occurring antibiotic complex from Streptomyces kanamyceticus that consists of several components: kanamycin A, the major component (also usually designated as kanamycin), and kanamycins B, C, D and X the minor components.		2.3110kanamycinsbacterial metabolite
1,2-dipalmitoylphosphatidylcholine
1,2-Dipalmitoylphosphatidylcholine: Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.		2.0610
vancomycin
Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.. vancomycin : A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.		2.8530glycopeptideantibacterial drug;
antimicrobial agent;
bacterial metabolite
1,2-dipalmitoylphosphatidylglycerol
dipalmitoyl phosphatidylglycerol : A phosphatidylglycerol in which the phosphatidyl acyl groups are both palmitoyl.		2.0610phosphatidylglycerol
triazoles
Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.		2.15101,2,3-triazole
gentamicin c1
[no description available]		2.3110
6-carboxyfluorescein
6-carboxyfluorescein: originally sold as 6-carboxyfluorescein, but commercial product is a mixture of two isomers; correct name is 5(6)-carboxyfluorescein		2.4720monocarboxylic acid
imipenem, anhydrous
Imipenem: Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.. imipenem : A broad-spectrum, intravenous beta-lactam antibiotic of the carbapenem subgroup.		2.3110beta-lactam antibiotic allergen;
carbapenems;
zwitterion		antibacterial drug
meropenem
Meropenem: A thienamycin derivative antibacterial agent that is more stable to renal dehydropeptidase I than IMIPENEM, but does not need to be given with an enzyme inhibitor such as CILASTATIN. It is used in the treatment of bacterial infections, including infections in immunocompromised patients.. meropenem : A carbapenemcarboxylic acid in which the azetidine and pyrroline rings carry 1-hydroxymethyl and in which the azetidine and pyrroline rings carry 1-hydroxymethyl and 5-(dimethylcarbamoyl)pyrrolidin-3-ylthio substituents respectively.		2.3110alpha,beta-unsaturated monocarboxylic acid;
carbapenemcarboxylic acid;
organic sulfide;
pyrrolidinecarboxamide		antibacterial agent;
antibacterial drug;
drug allergen
1,2-oleoylphosphatidylcholine
1,2-oleoylphosphatidylcholine: RN given refers to (Z,Z)-isomer. dioleoyl phosphatidylcholine : A phosphatidylcholine in which the phosphatidyl acyl groups are both oleoyl.		2.0710phosphatidylcholine(1+)
cefotaxime
Cefotaxime: Semisynthetic broad-spectrum cephalosporin.. cefotaxime : A cephalosporin compound having acetoxymethyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side groups.		2.31101,3-thiazoles;
cephalosporin;
oxime O-ether		antibacterial drug;
drug allergen
mastoparan
[no description available]		2.0510mastoparans;
peptidyl amide		antimicrobial agent
baci-im
[no description available]		2.3110homodetic cyclic peptide;
polypeptide;
zwitterion		antibacterial agent;
antimicrobial agent
polymyxin b(1)
[no description available]		2.6620
mast cell degranulating peptide
mast cell degranulating peptide: isolated from bee venoms; made up of 22 amino acids; has 2 disulfide bridges		2.0510
forapin
Forapin: used as ointment for treatment of myositis & arthritis; contains bee venom, salicylate, nicotinate & vanillylnonamide		2.3110peptidyl amide;
polypeptide		animal metabolite;
antineoplastic agent;
apoptosis inducer;
EC 2.7.11.13 (protein kinase C) inhibitor;
hepatoprotective agent;
neuroprotective agent;
venom
phosphatidylcholines
Phosphatidylcholines: Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a CHOLINE moiety.		2.07101,2-diacyl-sn-glycero-3-phosphocholine
chitosan
[no description available]		2.1110
1,2-dioleoyl-sn-glycero-3-phosphoglycerol
1,2-dioleoyl-sn-glycero-3-phospho-(1'-sn-glycerol) : A 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) in which both acyl groups are specified as oleoyl.		2.07101,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)
rifampin
Rifampin: A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)		2.930cyclic ketal;
hydrazone;
N-iminopiperazine;
N-methylpiperazine;
rifamycins;
semisynthetic derivative;
zwitterion		angiogenesis inhibitor;
antiamoebic agent;
antineoplastic agent;
antitubercular agent;
DNA synthesis inhibitor;
EC 2.7.7.6 (RNA polymerase) inhibitor;
Escherichia coli metabolite;
geroprotector;
leprostatic drug;
neuroprotective agent;
pregnane X receptor agonist;
protein synthesis inhibitor
temporin
temporin: isolated from frogs Rana temporaria & R. clamitans; has many isoforms; amino acid sequence in first source		2.0710
ConditionIndicatedRelationship StrengthStudiesTrials
ER-Negative PR-Negative HER2-Negative Breast Cancer
[description not available]		02.8220
B16 Melanoma
[description not available]		02.3110
Triple Negative Breast Neoplasms
Breast neoplasms that do not express ESTROGEN RECEPTORS; PROGESTERONE RECEPTORS; and do not overexpress the NEU RECEPTOR/HER-2 PROTO-ONCOGENE PROTEIN.		02.8220
Bacterial Pneumonia
[description not available]		07.3110
Pneumonia, Bacterial
Inflammation of the lung parenchyma that is caused by bacterial infections.		02.3110
Bacterial Disease
[description not available]		02.2510
Bacterial Infections
Infections by bacteria, general or unspecified.		02.2510
Di Guglielmo Disease
[description not available]		02.0810
Leukemia, Erythroblastic, Acute
A myeloproliferative disorder characterized by neoplastic proliferation of erythroblastic and myeloblastic elements with atypical erythroblasts and myeloblasts in the peripheral blood.		02.0810
Extravascular Hemolysis
[description not available]		03.3260
Hemolysis
The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.		03.3260