Compounds > 1h-benzotriazole-5-carboxylic acid
Page last updated: 2024-12-06

1h-benzotriazole-5-carboxylic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

1H-benzotriazole-5-carboxylic acid (BTCA) is a heterocyclic organic compound that has been studied for its potential applications in various fields. BTCA can be synthesized through various methods, including the oxidation of 5-methylbenzotriazole or the reaction of 5-aminobenzotriazole with carbon dioxide. BTCA exhibits diverse biological activities, including antibacterial, antifungal, and anti-inflammatory properties. The compound has also been explored for its potential in corrosion inhibition and as a precursor for the synthesis of pharmaceuticals and other organic molecules. Its unique structural features, including the benzotriazole ring and the carboxylic acid group, contribute to its potential versatility and applications in various fields. Research on BTCA focuses on understanding its synthesis, properties, and potential applications, contributing to the development of new materials and pharmaceuticals.'

1H-benzotriazole-5-carboxylic acid: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID72917
CHEMBL ID373015
SCHEMBL ID119640
MeSH IDM0172135

Synonyms (64)

Synonym
AC-1702
BB 0217050
OPREA1_101982
1h-benzotriazolecarboxylic acid
3h-benzotriazole-5-carboxylic acid
DIVK1C_001253
CDS1_000213
1h-benzotriazole-5-carboxylic acid
23814-12-2
OPREA1_856379
benzotriazole-5-carboxylic acid, 99%
MAYBRIDGE1_002501
STK396305
1h-benzotriazole-6-carboxylic acid
AKOS000104185
AKOS000268867
HMS548J15
2h-benzotriazole-5-carboxylic acid
CHEMBL373015
F1791-0657
FT-0694365
60932-58-3
1h-1,2,3-benzotriazole-5-carboxylic acid
benzotriazole-5-carboxylic acid
benzotriazole-5-cooh
BBL012552
5-benzotriazolecarboxylic acid
B3869
5-carboxybenzotriazole
1h-benzotriazolecarboxylicacid
einecs 262-527-4
1h-benzo[d][1,2,3]triazole-5-carboxylic acid
BP-12376
FT-0607864
benzotriazole-6-carboxylic acid
1h-benzo[d][1,2,3]triazole-6-carboxylic acid
SC4277
AB01105617-03
SCHEMBL119640
1h-benzo[d]-[1,2,3]triazole-5-carboxylic acid
1h-1,2,3-benzotriazole-6-carboxylic acid
5-carboxy-benzotriazole
mfcd00012318
SY002052
TS-00111
STR04366
CS-W019369
1288339-47-8
2h-benzo[d][1,2,3]triazole-5-carboxylic acid
49636-03-5
3h-benzotriazole-5-carboxylic acid, aldrichcpr
mfcd22123440
J-015223
NCGC00334824-01
5-carboxylbenzotriazole
Q63393716
AMY2938
mfcd00603072
CK2159
DTXSID10881049
SB66975
EN300-09511
PD162608
Z1718361949
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (4)

Assay IDTitleYearJournalArticle
AID260311Activity against GPR109a upto 100 uM2006Journal of medicinal chemistry, Feb-23, Volume: 49, Issue:4
1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b.
AID260310Agonistic activity at GPR109b by cAMP whole cell assay2006Journal of medicinal chemistry, Feb-23, Volume: 49, Issue:4
1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b.
AID667489Inhibition of recombinant type N-terminal His6-tagged 2 R67 DHFR expressed in Escherichia coli BL21 using DHF as substrate by spectrophotometry2012Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7
Fragment-based design of symmetrical bis-benzimidazoles as selective inhibitors of the trimethoprim-resistant, type II R67 dihydrofolate reductase.
AID667493Inhibition of human chromosomal DHFR expressed in Escherichia coli BL21 using DHF as substrate assessed as remaining activity at 30 mM by spectrophotometry relative to control2012Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7
Fragment-based design of symmetrical bis-benzimidazoles as selective inhibitors of the trimethoprim-resistant, type II R67 dihydrofolate reductase.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (16.67)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's3 (50.00)24.3611
2020's1 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 23.68

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index23.68 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.88 (4.65)
Search Engine Demand Index18.60 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (23.68)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
trimethoprim
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.. trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.		2.0710aminopyrimidine;
methoxybenzenes		antibacterial drug;
diuretic;
drug allergen;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
environmental contaminant;
xenobiotic
benzimidazole
1H-benzimidazole : The 1H-tautomer of benzimidazole.		2.0710benzimidazole;
polycyclic heteroarene
piperonylic acid
piperonylic acid: RN given refers to parent cpd; structure. piperonylic acid : A member of the class of benzodioxoles that is 1,3-benzodioxole substituted by a carboxy group at position 5. It is a natural product isolated from several plant species. It is a selective mechanism-based inactivator of the trans-cinnamate 4-hydroxylase enzyme and exhibits antifungal and skin wound healing properties.		2.0710aromatic carboxylic acid;
benzodioxoles;
monocarboxylic acid		antifungal agent;
EC 1.14.14.91 ( trans-cinnamate 4-monooxygenase) inhibitor;
plant metabolite;
vulnerary
benzotriazole
benzotriazole: inhibitor of atmospheric metal corrosion; also component of motion picture film & Neva brake fluid. benzotriazole : The simplest member of the class of benzotriazoles that consists of a benzene nucleus fused to a 1H-1,2,3-triazole ring.		2.110benzotriazolesenvironmental contaminant;
xenobiotic
1-hydroxyphthalazine
1-hydroxyphthalazine: RN given refers to cpd with unspecified locants; do not confuse with cpd phthalazinol RN: 56611-65-5		2.0710phthalazines
congo red
Congo Red: An acid dye used in testing for hydrochloric acid in gastric contents. It is also used histologically to test for AMYLOIDOSIS.. Congo Red : An indicator dye that is blue-violet at pH 3.0 and red at pH 5.0.		2.0710bis(azo) compound
triazoles
Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.		2.96401,2,3-triazole
6-Methoxy-2-naphthoic acid
[no description available]		2.0710naphthoic acid
5-benzimidazolecarboxylic acid
5-benzimidazolecarboxylic acid: structure in first source		2.0710
1-propan-2-yl-5-benzotriazolecarboxylic acid
[no description available]		2.4520benzotriazoles
novobiocin
Novobiocin: An antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189). novobiocin : A coumarin-derived antibiotic obtained from Streptomyces niveus.		2.0710carbamate ester;
ether;
hexoside;
hydroxycoumarin;
monocarboxylic acid amide;
monosaccharide derivative;
phenols		antibacterial agent;
antimicrobial agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
Escherichia coli metabolite;
hepatoprotective agent
1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1h-benzotriazole-5-carboxylic acid
1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5-carboxylic acid: a partial RXR agonist; structure in first source		7.0810
ConditionIndicatedRelationship StrengthStudiesTrials
Diabetes Mellitus, Adult-Onset
[description not available]		02.0810
Diabetes Mellitus, Type 2
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.		02.0810