urazole profile

Urazole is a heterocyclic organic compound with the formula (NH)2C2O. It is a white solid that is soluble in water and ethanol. Urazole is a weak acid and can be used as a reagent in organic synthesis. It is also used as a precursor to other heterocyclic compounds. Urazole is known for its ability to form metal complexes. Its synthesis typically involves the reaction of hydrazine with urea. Some research focuses on the potential of urazole derivatives for medicinal applications. For example, certain derivatives exhibit anti-inflammatory and antimicrobial activity. The study of urazole is of interest due to its versatility in chemical reactions and its potential for various applications.'

urazole: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	72916
CHEMBL ID	1996517
SCHEMBL ID	130780
MeSH ID	M0380474

Synonym
nsc-1892
urazole
nsc1892
bicarbamimide
1h-1,4-triazole-3,5(2h,4h)-dione
urazol
1,4-triazolidine-3,5-dione
3232-84-6
s-triazole-3,5-diol
urazole bicarbamide
s-triazole-2,5-diol
NCI60_001576
nsc-15394
nsc15394
1,2,4-triazolidine-3,5-dione
urazole, 97%
U0045
nsc 15394
bicarbamimide (van)
ai3-61104
u4vgb8c36d ,
1h-1,2,4-triazole-3,5(2h,4h)-dione
1,2,4-triazole-3,5-diol
3,5-dihydroxy-1,2,4-triazole
einecs 221-776-9
unii-u4vgb8c36d
nsc 1892
AKOS015913604
SCHEMBL130780
3,5-diketotriazolidine
urazole [mi]
DTXSID5062920
CHEMBL1996517
tetrahydro-1,2,4-triazole-dione
J-640166
J-800168
mfcd00005225
AS-59390
5-hydroxy-2,4-dihydro-3h-1,2,4-triazol-3-one
5-hydroxy-1,2-dihydro-3h-1,2,4-triazol-3-one
4h-1,2,4-triazole-3,5-diol
CS-0120009
Q27290691
D92762
EN300-243808
Z1255461133

Excerpt	Reference	Relevance
"Urazole has been used in many heterocyclic compounds which are valuable in organic syntheses. "	( The Molecular Diversity Scope of Urazole in the Synthesis of Organic Compounds. Mofatehnia, P; Mohajer, F; Moradi, R; Ziarani, GM, 2019)	2.24

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	5 (26.32)	18.7374
1990's	0 (0.00)	18.2507
2000's	5 (26.32)	29.6817
2010's	6 (31.58)	24.3611
2020's	3 (15.79)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	19 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
urea pseudourea: clinical use; structure. isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.	1.93	1	isourea; monocarboxylic acid amide; one-carbon compound	Daphnia magna metabolite; Escherichia coli metabolite; fertilizer; flour treatment agent; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
amitrole Amitrole: A non-selective post-emergence, translocated herbicide. According to the Seventh Annual Report on Carcinogens (PB95-109781, 1994) this substance may reasonably be anticipated to be a carcinogen. (From Merck Index, 12th ed) It is an irreversible inhibitor of CATALASE, and thus impairs activity of peroxisomes.. amitrole : A member of the class of triazoles that is 1H-1,2,4-triazole substituted by an amino group at position 3. Used to control annual grasses and aquatic weeds (but not on food crops because it causes cancer in laboratory animals). Its use within the EU was banned from September 2017 on the grounds of potential groundwater contamination and risks to aquatic life; there have also been concerns about its endocrine-disrupting properties.	7.02	1	aromatic amine; triazoles	carotenoid biosynthesis inhibitor; EC 1.11.1.6 (catalase) inhibitor; herbicide
glutaral Glutaral: One of the protein CROSS-LINKING REAGENTS that is used as a disinfectant for sterilization of heat-sensitive equipment and as a laboratory reagent, especially as a fixative.. glutaraldehyde : A dialdehyde comprised of pentane with aldehyde functions at C-1 and C-5.	2.06	1	dialdehyde	cross-linking reagent; disinfectant; fixative
tyrosine Tyrosine: A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.. tyrosine : An alpha-amino acid that is phenylalanine bearing a hydroxy substituent at position 4 on the phenyl ring.	7.61	2	amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; proteinogenic amino acid; tyrosine	EC 1.3.1.43 (arogenate dehydrogenase) inhibitor; fundamental metabolite; micronutrient; nutraceutical
indazoles Indazoles: A group of heterocyclic aromatic organic compounds consisting of the fusion of BENZENE and PYRAZOLES.	2.52	2	indazole
propiolic acid propiolic acid: RN given refers to parent cpd; structure. propynoic acid : A terminal acetylenic compound that is a 3-carbon, straight-chain, monounsaturated fatty acid having one acetylenic bond.	2.01	1	acetylenic fatty acid; alpha,beta-unsaturated monocarboxylic acid; monounsaturated fatty acid; short-chain fatty acid; terminal acetylenic compound	xenobiotic metabolite
maleimide [no description available]	2.02	1	dicarboximide; maleimides	EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor
galactose aldohexose : A hexose with a (potential) aldehyde group at one end.	2	1
tiletamine hydrochloride Cyclohexanones: Cyclohexane ring substituted by one or more ketones in any position.. cyclohexanones : Any alicyclic ketone based on a cyclohexane skeleton and its substituted derivatives thereof.	2.06	1
dimedone dimedone: RN given refers to parent cpd; structure	7.06	1
glutamic acid Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.. glutamic acid : An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2.	2.06	1	glutamic acid; glutamine family amino acid; L-alpha-amino acid; proteinogenic amino acid	Escherichia coli metabolite; ferroptosis inducer; micronutrient; mouse metabolite; neurotransmitter; nutraceutical
triazoles Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.	4.24	18	1,2,3-triazole
phosphorus Phosphorus: A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.	2.06	1	monoatomic phosphorus; nonmetal atom; pnictogen	macronutrient

Condition	Relationship Strength	Studies
Calcification, Pathologic [description not available]	2.06	1
Calcinosis Pathologic deposition of calcium salts in tissues.	2.06	1
Brain Inflammation [description not available]	1.93	1
Encephalitis, Japanese B [description not available]	1.93	1
Encephalitis Inflammation of the BRAIN due to infection, autoimmune processes, toxins, and other conditions. Viral infections (see ENCEPHALITIS, VIRAL) are a relatively frequent cause of this condition.	1.93	1
Encephalitis, Japanese A mosquito-borne encephalitis caused by the Japanese B encephalitis virus (ENCEPHALITIS VIRUS, JAPANESE) occurring throughout Eastern Asia and Australia. The majority of infections occur in children and are subclinical or have features limited to transient fever and gastrointestinal symptoms. Inflammation of the brain, spinal cord, and meninges may occur and lead to transient or permanent neurologic deficits (including a POLIOMYELITIS-like presentation); SEIZURES; COMA; and death. (From Adams et al., Principles of Neurology, 6th ed, p751; Lancet 1998 Apr 11;351(9109):1094-7)	1.93	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.02	1

urazole

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Research Demand Index: 35.73

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