ibrexafungerp: a glucan synthase inhibitor with antifungal activity; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
ID Source | ID |
---|---|
PubMed CID | 46871657 |
CHEMBL ID | 4297513 |
SCHEMBL ID | 3479266 |
MeSH ID | M0569976 |
Synonym |
---|
mk-3118 |
SCHEMBL3479266 |
ibrexafungerp |
scy-078 |
ibrexafungerp [who-dd] |
1207753-03-4 |
(1s,4ar,6as,7r,8r,10ar,10br,12ar,14r,15r)-15-((2r)- 2-amino-2,3,3-trimethylbutoxy)-1,6a,8,10a-tetramethyl-8- ((2r)-3-methylbutan-2-yl)-14-(5-(pyridin-4-yl)-1h-1,2,4- triazol-1-yl)-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-2h,4h-1,4a-propanophenanthro( |
A92JFM5XNU , |
mk-3118 free base |
ibrexafungerp [inn] |
mk3118 |
4h-1,4a-propano-2h-phenanthro(1,2-c)pyran-7-carboxylic acid, 15-((2r)-2-amino-2,3,3-trimethylbutoxy)-8-((1r)-1,2-dimethylpropyl)-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-14-(5-(4-pyridinyl)-1h-1,2,4-triazol-1-yl)-, (1s,4ar,6as, |
ibrexafungerp [usan] |
unii-a92jfm5xnu |
who 10597 |
DB12471 |
AKOS032946516 |
mk 3118 |
EX-A7291 |
BODYFEUFKHPRCK-ZCZMVWJSSA-N |
(1s,4ar,6as,7r,8r,10ar,10br,12ar,14r,15r)-15-[[(2r)-2-amino-2,3,3-trimethylbutyl]oxy]-8-[(1r)-1,2-dimethylpropyl]-14-[5-(4-pyridinyl)-1h-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4h-1,4a-propano-2h-phenanthro |
D11544 |
ibrexafungerp (usan) |
Q27273787 |
CHEMBL4297513 |
DTXSID901336871 |
scy 078 |
(1s,4ar,6as,7r,8r,10ar,10br,12ar,14r,15r)-15-((2r)-2-amino-2,3,3-trimethylbutoxy)-1,6a,8,10a-tetramethyl-8-((2r)-3-methylbutan-2-yl)-14-(5-(pyridin-4-yl)-1h-1,2,4-triazol-1-yl)-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-2h,4h-1,4a-propanophenanthro(1,2 |
scy078 |
ibrexafungerpum |
Excerpt | Reference | Relevance |
---|---|---|
" Adverse events were primarily gastrointestinal and were mild to moderate in severity." | ( Efficacy and safety of oral ibrexafungerp for the treatment of acute vulvovaginal candidiasis: a global phase 3, randomised, placebo-controlled superiority study (VANISH 306). Angulo, D; Azie, NE; Borroto-Esoda, K; Delchev, DA; Ghannoum, MA; Harriott, IA; Nyirjesy, P; Sobel, JD; Sobel, R, 2022) | 0.72 |
Excerpt | Reference | Relevance |
---|---|---|
" To examine clinically relevant effects of the potential interaction with SCY-078, this phase 1, open-label, 2-period crossover study evaluated the pharmacokinetic parameters of rosiglitazone, a sensitive substrate of CYP2C8 metabolism, in the absence and presence of SCY-078 dosed to therapeutically relevant SCY-078 concentration exposure after repeat dosing." | ( Lack of Impact by SCY-078, a First-in-Class Oral Fungicidal Glucan Synthase Inhibitor, on the Pharmacokinetics of Rosiglitazone, a Substrate for CYP450 2C8, Supports the Low Risk for Clinically Relevant Metabolic Drug-Drug Interactions. Angulo, D; Atiee, G; Corr, C; Hyman, M; Murphy, G; Willett, M; Wring, S, 2018) | 0.48 |
" Pharmacokinetic (PK) parameters were compared to assess both the impact of steady-state SCY-078 on tacrolimus and the impact of tacrolimus on the PK of steady-state SCY-078." | ( Clinical Pharmacokinetics and Drug-Drug Interaction Potential for Coadministered SCY-078, an Oral Fungicidal Glucan Synthase Inhibitor, and Tacrolimus. Angulo, D; Atiee, G; Corr, C; Hyman, M; Murphy, G; Willett, M; Wring, S, 2019) | 0.51 |
Excerpt | Reference | Relevance |
---|---|---|
" This was a sequential, single-center, open-label phase 1 study to assess the drug-drug interaction potential between SCY-078 and tacrolimus during concomitant administration in healthy subjects." | ( Clinical Pharmacokinetics and Drug-Drug Interaction Potential for Coadministered SCY-078, an Oral Fungicidal Glucan Synthase Inhibitor, and Tacrolimus. Angulo, D; Atiee, G; Corr, C; Hyman, M; Murphy, G; Willett, M; Wring, S, 2019) | 0.51 |
Excerpt | Reference | Relevance |
---|---|---|
"To evaluate the activity of the orally bioavailable enfumafungin derivative MK-3118 and comparator antifungal agents tested against a collection of 113 clinical isolates of Candida spp." | ( Activity of MK-3118, a new oral glucan synthase inhibitor, tested against Candida spp. by two international methods (CLSI and EUCAST). Castanheira, M; Jones, RN; Messer, SA; Motyl, MR; Pfaller, MA, 2013) | 1 |
" Derivatives of enfumafungin are novel orally bioavailable glucan synthase inhibitors." | ( Pharmacodynamic target evaluation of a novel oral glucan synthase inhibitor, SCY-078 (MK-3118), using an in vivo murine invasive candidiasis model. Andes, DR; Lepak, AJ; Marchillo, K, 2015) | 0.64 |
"We studied the antifungal activity of SCY-078 (an orally bioavailable 1,3-β -d- glucan synthesis inhibitor), micafungin and fluconazole against the planktonic and sessile forms of 178 Candida and non- Candida isolates causing fungaemia in patients recently admitted to a large European hospital." | ( The novel oral glucan synthase inhibitor SCY-078 shows in vitro activity against sessile and planktonic Candida spp. Bouza, E; Escribano, P; Gómez-Perosanz, M; Guinea, J; Marcos-Zambrano, LJ, 2017) | 0.46 |
"SCY-078 is an orally bioavailable triterpenoid glucan synthase inhibitor in clinical development as an intravenous and oral treatment of fungal infections caused by Candida and Aspergillus species." | ( Clinical Pharmacokinetics and Drug-Drug Interaction Potential for Coadministered SCY-078, an Oral Fungicidal Glucan Synthase Inhibitor, and Tacrolimus. Angulo, D; Atiee, G; Corr, C; Hyman, M; Murphy, G; Willett, M; Wring, S, 2019) | 0.51 |
"To evaluate the safety and efficacy of two dosing regimens of oral ibrexafungerp (formerly SCY-078), a novel orally bioavailable β-glucan synthase inhibitor, in subjects with invasive candidiasis versus the standard of care (SOC) and to identify the dose to achieve target exposure (15." | ( MSG-10: a Phase 2 study of oral ibrexafungerp (SCY-078) following initial echinocandin therapy in non-neutropenic patients with invasive candidiasis. Angulo, D; Helou, S; Pappas, PG; Powderly, WG; Pullman, J; Spec, A; Thompson, GR; Tobin, EH; Vazquez, J; Wring, SA, 2019) | 0.51 |
Excerpt | Relevance | Reference |
---|---|---|
" To examine clinically relevant effects of the potential interaction with SCY-078, this phase 1, open-label, 2-period crossover study evaluated the pharmacokinetic parameters of rosiglitazone, a sensitive substrate of CYP2C8 metabolism, in the absence and presence of SCY-078 dosed to therapeutically relevant SCY-078 concentration exposure after repeat dosing." | ( Lack of Impact by SCY-078, a First-in-Class Oral Fungicidal Glucan Synthase Inhibitor, on the Pharmacokinetics of Rosiglitazone, a Substrate for CYP450 2C8, Supports the Low Risk for Clinically Relevant Metabolic Drug-Drug Interactions. Angulo, D; Atiee, G; Corr, C; Hyman, M; Murphy, G; Willett, M; Wring, S, 2018) | 0.48 |
"To evaluate the safety and efficacy of two dosing regimens of oral ibrexafungerp (formerly SCY-078), a novel orally bioavailable β-glucan synthase inhibitor, in subjects with invasive candidiasis versus the standard of care (SOC) and to identify the dose to achieve target exposure (15." | ( MSG-10: a Phase 2 study of oral ibrexafungerp (SCY-078) following initial echinocandin therapy in non-neutropenic patients with invasive candidiasis. Angulo, D; Helou, S; Pappas, PG; Powderly, WG; Pullman, J; Spec, A; Thompson, GR; Tobin, EH; Vazquez, J; Wring, SA, 2019) | 0.51 |
"In a multinational, open-label study, patients with documented invasive candidiasis were randomized to receive step-down therapy to one of three treatment arms: two dosing regimens of novel oral ibrexafungerp or the SOC treatment following initial echinocandin therapy." | ( MSG-10: a Phase 2 study of oral ibrexafungerp (SCY-078) following initial echinocandin therapy in non-neutropenic patients with invasive candidiasis. Angulo, D; Helou, S; Pappas, PG; Powderly, WG; Pullman, J; Spec, A; Thompson, GR; Tobin, EH; Vazquez, J; Wring, SA, 2019) | 0.51 |
" In December 2022, Ibrexafungerp received FDA approval for once monthly dosing to decrease the incidence of RVVC." | ( Ibrexafungerp for the Treatment of Vulvovaginal Candidiasis: Design, Development and Place in Therapy. Merjanian, L; Phillips, NA; Rocktashel, M, 2023) | 0.91 |
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID1692957 | Antifungal activity against Candida tropicalis MY1012 assessed as fungal growth inhibition | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692917 | Antifungal activity against Candida albicans MY1055 infected in DBA/2 mouse model of disseminated candidiasis assessed as reduction in fungal burden in kidney by measuring log change in colony forming units at 25 mg/kg, po bid for 7 days by TOKA | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692912 | Dose normalized AUC in po dosed mouse | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692952 | Antifungal activity against Aspergillus fumigatus MF5668 infected in DBA/2N mouse assessed as mean survival time at ED50, ip administered bid administered for 7 days starting from 15 to 30 mins post infection and measured up to 21 days | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692924 | Dose normalized AUC in po dosed rat | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692928 | Dose normalized AUC in po dosed dog | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692925 | Oral bioavailability in rat | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692948 | Antifungal activity against Aspergillus fumigatus MF5668 infected in DBA/2N mouse assessed as mean survival time at 12.5 mg/kg, ip bid administered for 7 days starting from 15 to 30 mins post infection and measured up to 21 days | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692966 | Antifungal activity against Aspergillus fumigatus MF5668 infected in DBA/2N mouse assessed as mouse survival at 1.56 mg/kg, ip bid administered for 7 days starting from 15 to 30 mins post infection and measured up to 21 days relative to control | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692960 | Antifungal activity against Candida glabrata MY1381 assessed as reduction in fungal growth | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692910 | Antifungal activity against Aspergillus fumigatus MF5668 assessed inhibition of fungal growth by measuring morphological changes measured after 24 hrs by microscopy | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692919 | Antifungal activity against Candida albicans MY1055 infected in DBA/2 mouse model of disseminated candidiasis assessed as reduction in fungal burden in kidney by measuring log change in colony forming units at 6.25 mg/kg, po bid for 7 days by TOKA | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692932 | Dose normalized AUC in po rhesus monkey | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692958 | Antifungal activity against Clavispora lusitaniae MY1396 assessed as fungal growth inhibition | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692920 | Clearance in mouse | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692923 | Half life in rat | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692963 | Antifungal activity against Clavispora lusitaniae MY1396 assessed as reduction in fungal growth | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692933 | Oral bioavailability in rhesus monkey | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692942 | Antifungal activity against Aspergillus fumigatus MF5668 infected in DBA/2N mouse assessed as mouse survival at 3.125 mg/kg, ip bid administered for 7 days starting from 15 to 30 mins post infection and measured up to 21 days relative to control | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692926 | Clearance in dog | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692918 | Antifungal activity against Candida albicans MY1055 infected in DBA/2 mouse model of disseminated candidiasis assessed as reduction in fungal burden in kidney by measuring log change in colony forming units at 12.5 mg/kg, po bid for 7 days by TOKA | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692961 | Antifungal activity against Candida krusei ATCC 6258 assessed as reduction in fungal growth | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692965 | Antifungal activity against Aspergillus fumigatus MF5668 assessed inhibition of fungal growth by measuring morphological changes in presence of 50% human serum measured after 24 hrs by microscopy | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692913 | Oral bioavailability in mouse | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692964 | Antifungal activity against Candida parapsilosis ATCC 22019 assessed as reduction in fungal growth | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692955 | Antifungal activity against Candida glabrata MY1381 assessed as fungal growth inhibition | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692922 | Clearance in rat | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692911 | Antifungal activity against Candida albicans MY1055 assessed as fungal growth inhibition measured after 24 hrs in presence of 50% mouse serum by liquid microdilution method | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692938 | Antifungal activity against Candida albicans MY1055 infected in ip dosed DBA/2 mouse model of disseminated candidiasis assessed as reduction in fungal burden in kidney administered bid for 7 days by TOKA | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692956 | Antifungal activity against Candida krusei ATCC 6258 assessed as fungal growth inhibition | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692947 | Antifungal activity against Aspergillus fumigatus MF5668 infected in ip dosed DBA/2N mouse assessed as 90% mouse survival administered bid administered for 7 days starting from 15 to 30 mins post infection and measured up to 21 days | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692927 | Half life in dog | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692931 | Half life in rhesus monkey | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692972 | Antifungal activity against Candida albicans MY1055 assessed as reduction in fungal growth | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692908 | Inhibition of beta-1,3-glucan synthase in Candida albicans MY1055 microsomal membrane assessed as inhibition of TCA-insoluble material formation using UDP-[3H]-glucose as substrate incubated for 2 hrs in presence of GTP by radioactivity-based assay | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692954 | Antifungal activity against Candida albicans MY1055 assessed as reduction in fungal growth in presence of 50% mouse serum | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692929 | Oral bioavailability in dog | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692962 | Antifungal activity against Candida tropicalis MY1012 assessed as reduction in fungal growth | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692939 | Antifungal activity against Candida albicans MY1055 infected in DBA/2 mouse model of disseminated candidiasis assessed as reduction in fungal burden in kidney by measuring log change in colony forming units at 12.5 mg/kg, ip bid for 7 days by TOKA | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692921 | Half life in mouse | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692949 | Antifungal activity against Aspergillus fumigatus MF5668 infected in DBA/2N mouse assessed as mean survival time at 6.25 mg/kg, ip bid administered for 7 days starting from 15 to 30 mins post infection and measured up to 21 days | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692941 | Antifungal activity against Aspergillus fumigatus MF5668 infected in DBA/2N mouse assessed as mouse survival at 6.25 mg/kg, ip bid administered for 7 days starting from 15 to 30 mins post infection and measured up to 21 days relative to control | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692953 | Antifungal activity against Aspergillus fumigatus MF5668 infected in DBA/2N mouse assessed as mean survival time at ED90, ip administered bid administered for 7 days starting from 15 to 30 mins post infection and measured up to 21 days | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692971 | Antifungal activity against Candida albicans MY1055 assessed as fungal growth inhibition in presence of 50% mouse serum | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692940 | Antifungal activity against Aspergillus fumigatus MF5668 infected in DBA/2N mouse assessed as mouse survival at 12.5 mg/kg, ip bid administered for 7 days starting from 15 to 30 mins post infection and measured up to 21 days relative to control | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692959 | Antifungal activity against Candida parapsilosis ATCC 22019 assessed as fungal growth inhibition | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692930 | Clearance in rhesus monkey | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692909 | Antifungal activity against Candida albicans MY1055 assessed as fungal growth inhibition measured after 24 hrs by liquid microdilution method | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692967 | Antifungal activity against Aspergillus fumigatus MF5668 infected in DBA/2N mouse assessed as mean survival time at 1.56 mg/kg, ip bid administered for 7 days starting from 15 to 30 mins post infection and measured up to 21 days | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
AID1692950 | Antifungal activity against Aspergillus fumigatus MF5668 infected in DBA/2N mouse assessed as mean survival time at 3.125 mg/kg, ip bid administered for 7 days starting from 15 to 30 mins post infection and measured up to 21 days | 2021 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 32 | Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 21 (44.68) | 24.3611 |
2020's | 26 (55.32) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (26.38) All Compounds (24.57) |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 6 (12.50%) | 5.53% |
Reviews | 10 (20.83%) | 6.00% |
Case Studies | 1 (2.08%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 31 (64.58%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |