Page last updated: 2024-09-28

Nelson Syndrome

A syndrome characterized by HYPERPIGMENTATION, enlarging pituitary mass, visual defects secondary to compression of the OPTIC CHIASM, and elevated serum ACTH. It is caused by the expansion of an underlying ACTH-SECRETING PITUITARY ADENOMA that grows in the absence of feedback inhibition by adrenal CORTICOSTEROIDS, usually after ADRENALECTOMY.

Synonyms(1)

Synonym
Nelson Syndrome

Research

Studies (171)

TimeframeStudies, This Condition (%)All Conditions %
pre-1990114 (66.67)23.3326
1990's21 (12.28)12.5806
2000's22 (12.87)18.1394
2010's10 (5.85)28.8240
2020's4 (2.34)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0medium41
putrescine0low10
spermidine0low10
cyproheptadine0medium121
diazepam0low10
pentetic acid0low10
valproic acid0medium165
gentamicin0low10
haloperidol0low20
indomethacin0low10
ketanserin0medium22
ketoconazole0low30
methadone0low10
metoclopramide0low30
metyrapone0medium81
mitotane0low30
ritanserin0medium11
temozolomide0low60
prednisolone0low10
thyroxine0low10
aldosterone0low10
triiodothyronine0low10
chloramphenicol0low10
desoxycorticosterone0low10
methylprednisolone0low10
pregnenolone0low10
pyrazines0low10
gadolinium0low10
lisuride0low10
bromocriptine0medium132
fludrocortisone0low30
du-212200low10
enkephalin, methionine0low10
cabergoline0low30
capecitabine0low10
iopamidol0low10
triazoles0low10
fluorodeoxyglucose f180low10
adosterol0low10
rosiglitazone0low30
epidepride0low10
yttrium radioisotopes0low10
desmethylcyproheptadine0low10
cortisone0low10
inositol 3-phosphate0low10
metrizamide0low10
diethylstilbestrol0low10
enkephalin, leucine0low50
lypressin0medium111
arginine vasopressin0low60
17-ketosteroids0low10
calcitriol0medium11
naloxone0medium52
gadolinium dtpa0low10
ergoline0low30
nivazol0low10
pasireotide0low40
sitagliptin phosphate0low10
pituitrin0low10
cosyntropin0low20
cholecystokinin0low10
adrenocorticotropin zinc0low10
gastrins0low10
glucagon0low10
beta-endorphin0medium222
piperidines0medium11
interleukin-80low10
vasoactive intestinal peptide0low20
transforming growth factor beta0low10
d-ala(2),mephe(4),met(0)-ol-enkephalin0low10
dacarbazine0low30
concanavalin a0low10

Protein Targets (789)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
AR protein220022
glucocorticoid receptor [Homo sapiens]210021
thyroid hormone receptor beta isoform a9009
nuclear factor erythroid 2-related factor 2 isoform 25005
geminin160016
Sex hormone-binding globulin0044
Corticosteroid-binding globulin0505
Mineralocorticoid receptor 0336
Androgen receptor0707
Mineralocorticoid receptor0101
Solute carrier organic anion transporter family member 1A10001
Guanine nucleotide-binding protein G4004
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE9009
thioredoxin reductase9009
cytochrome P450 family 3 subfamily A polypeptide 4190019
estrogen-related nuclear receptor alpha200020
pregnane X nuclear receptor160016
estrogen nuclear receptor alpha270027
IDH16006
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a120012
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a9009
peripheral myelin protein 22 isoform 17007
potassium voltage-gated channel subfamily H member 2 isoform d9009
transcriptional regulator ERG isoform 32002
peptidyl-prolyl cis-trans isomerase NIMA-interacting 15005
cytochrome P450 3A4 isoform 19009
Gamma-aminobutyric acid receptor subunit pi95216
ATP-binding cassette sub-family C member 3017017
Multidrug resistance-associated protein 4017017
Sterol O-acyltransferase 10101
Bile salt export pump024024
Cholesterol side-chain cleavage enzyme, mitochondrial 0101
Triosephosphate isomerase0101
Steroid 17-alpha-hydroxylase/17,20 lyase0404
Cholesterol side-chain cleavage enzyme, mitochondrial0101
Aromatase0509
Gamma-aminobutyric acid receptor subunit beta-195216
Ribosyldihydronicotinamide dehydrogenase [quinone]0101
Gamma-aminobutyric acid receptor subunit delta95216
Gamma-aminobutyric acid receptor subunit gamma-295317
Gamma-aminobutyric acid receptor subunit alpha-595216
Gamma-aminobutyric acid receptor subunit alpha-395216
Aromatase0112
Gamma-aminobutyric acid receptor subunit gamma-195216
Gamma-aminobutyric acid receptor subunit alpha-295216
Thromboxane-A synthase 0505
Gamma-aminobutyric acid receptor subunit alpha-495216
Gamma-aminobutyric acid receptor subunit gamma-395216
Cytochrome P450 11B2, mitochondrial0101
Gamma-aminobutyric acid receptor subunit alpha-695216
Delta-type opioid receptor0529
Gamma-aminobutyric acid receptor subunit alpha-195317
Gamma-aminobutyric acid receptor subunit beta-395216
Gamma-aminobutyric acid receptor subunit beta-295317
GABA theta subunit95216
Canalicular multispecific organic anion transporter 1014014
Gamma-aminobutyric acid receptor subunit epsilon95216
vitamin D3 receptor isoform VDRA5005
peripheral myelin protein 22110011
Translocator protein0225
Vasopressin V2 receptor0214
Oxytocin receptor0112
Vasopressin V1a receptor0022
Vasopressin V1a receptor0314
Vasopressin V1b receptor0112
Vasopressin V2 receptor0011
Vasopressin V1b receptor0113
Translocator protein0102
Oxytocin receptor0101
Vasopressin V2 receptor 0112
Chain A, Diaminopimelate decarboxylase0101
Chain B, Diaminopimelate decarboxylase0101
Chain A, Ferritin light chain5005
phosphopantetheinyl transferase4004
RAR-related orphan receptor gamma160016
NFKB1 protein, partial4004
GLI family zinc finger 3160016
thyroid stimulating hormone receptor100010
estrogen receptor 2 (ER beta)8008
bromodomain adjacent to zinc finger domain 2B7007
arylsulfatase A5005
euchromatic histone-lysine N-methyltransferase 2160016
muscleblind-like protein 1 isoform 14004
lamin isoform A-delta10150015
TAR DNA-binding protein 436006
ATP-dependent phosphofructokinase9009
regulator of G-protein signaling 49009
histone acetyltransferase KAT2A isoform 16006
Genome polyprotein 0112
dopamine D1 receptor3003
ATAD5 protein, partial7007
Fumarate hydratase5005
GLS protein6006
TDP1 protein190019
G100010
polyprotein5005
peroxisome proliferator activated receptor gamma150015
D(1A) dopamine receptor7007
chromobox protein homolog 18008
thyroid hormone receptor beta isoform 2170017
serine/threonine-protein kinase mTOR isoform 16006
5-hydroxytryptamine receptor 4012012
Interferon beta160016
HLA class I histocompatibility antigen, B alpha chain 100010
Cellular tumor antigen p53180018
ATP-dependent translocase ABCB10303
ATP-dependent translocase ABCB10709
Beta-1 adrenergic receptor0606
Cytochrome P450 3A408112
5-hydroxytryptamine receptor 1A0538
Alpha-2A adrenergic receptor016016
D(2) dopamine receptor014319
Alpha-2B adrenergic receptor012012
Alpha-2C adrenergic receptor010010
D0606
D(3) dopamine receptor0606
5-hydroxytryptamine receptor 1A013114
Alpha-2B adrenergic receptor0303
ATP-dependent translocase ABCB10303
D(1A) dopamine receptor010011
Alpha-2C adrenergic receptor0303
Alpha-2A adrenergic receptor0303
Alpha-1D adrenergic receptor010010
D(1B) dopamine receptor0505
5-hydroxytryptamine receptor 2A016321
5-hydroxytryptamine receptor 2C016219
5-hydroxytryptamine receptor 1B0909
D(4) dopamine receptor0505
D(3) dopamine receptor013116
Alpha-synuclein1102
5-hydroxytryptamine receptor 2B018120
5-hydroxytryptamine receptor 6012012
D(2) dopamine receptor012214
Inositol hexakisphosphate kinase 1100010
ATPase family AAA domain-containing protein 57007
Ataxin-29009
cytochrome P450 2C9, partial100010
acetylcholinesterase7007
cytochrome P450 2D6100010
thyroid stimulating hormone receptor6006
Spike glycoprotein9009
Histamine H3 receptor0101
Chain A, Vitamin D Nuclear Receptor0011
Chain A, Beta-lactamase4004
Vitamin D3 receptor0011
USP1 protein, partial100010
PPM1D protein5005
Microtubule-associated protein tau7007
thioredoxin glutathione reductase1001
mitogen-activated protein kinase 14004
nuclear receptor ROR-gamma isoform 16006
Vitamin D-binding protein0011
Cytochrome P450 1A20102
Androgen receptor0415
Cytochrome P450 2D60606
Vitamin D3 receptor0124
Cytochrome P450 2C9 0416
Vitamin D3 receptor0113
Retinoic acid receptor RXR-alpha0033
Cytochrome P450 2C190202
Kappa-type opioid receptor0426
Vitamin D3 receptor0011
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial0213
Vitamin D3 receptor0112
Transporter0202
Vitamin D3 receptor A0022
Liver carboxylesterase 10102
interleukin 84004
aldehyde dehydrogenase 1 family, member A19009
EWS/FLI fusion protein100010
retinoic acid nuclear receptor alpha variant 1100010
farnesoid X nuclear receptor9009
vitamin D (1,25- dihydroxyvitamin D3) receptor110011
aryl hydrocarbon receptor6006
activating transcription factor 65005
heat shock protein beta-15005
nuclear factor erythroid 2-related factor 2 isoform 1130013
DNA polymerase iota isoform a (long)3003
streptokinase A precursor0011
lethal factor (plasmid)6006
Dihydroxyacetone phosphate acyltransferase0001
30S ribosomal protein S60101
30S ribosomal protein S70101
50S ribosomal protein L150101
50S ribosomal protein L100101
50S ribosomal protein L110101
50S ribosomal protein L7/L120101
50S ribosomal protein L190101
50S ribosomal protein L10101
50S ribosomal protein L200101
50S ribosomal protein L270101
50S ribosomal protein L280101
50S ribosomal protein L290101
50S ribosomal protein L310101
50S ribosomal protein L31 type B0101
50S ribosomal protein L320101
50S ribosomal protein L330101
50S ribosomal protein L340101
50S ribosomal protein L350101
50S ribosomal protein L360101
30S ribosomal protein S100101
30S ribosomal protein S110101
30S ribosomal protein S120101
30S ribosomal protein S130101
30S ribosomal protein S160101
30S ribosomal protein S180101
30S ribosomal protein S190101
30S ribosomal protein S200101
30S ribosomal protein S20101
30S ribosomal protein S30101
30S ribosomal protein S40101
30S ribosomal protein S50101
30S ribosomal protein S80101
30S ribosomal protein S90101
50S ribosomal protein L130101
50S ribosomal protein L140101
50S ribosomal protein L160101
50S ribosomal protein L230101
30S ribosomal protein S150101
50S ribosomal protein L170101
50S ribosomal protein L210101
50S ribosomal protein L300101
50S ribosomal protein L60101
30S ribosomal protein S140101
30S ribosomal protein S170101
30S ribosomal protein S10101
50S ribosomal protein L180101
50S ribosomal protein L20101
50S ribosomal protein L30101
50S ribosomal protein L240101
50S ribosomal protein L40101
50S ribosomal protein L220101
50S ribosomal protein L50101
30S ribosomal protein S210101
50S ribosomal protein L250101
50S ribosomal protein L36 20101
Methionine--tRNA ligase, mitochondrial0011
Chain A, HADH2 protein5005
Chain B, HADH2 protein5005
endonuclease IV2002
pregnane X receptor3003
progesterone receptor130013
retinoid X nuclear receptor alpha8008
peroxisome proliferator-activated receptor delta100010
v-jun sarcoma virus 17 oncogene homolog (avian)100010
atrial natriuretic peptide receptor 1 precursor1001
flap endonuclease 12002
survival motor neuron protein isoform d5005
M-phase phosphoprotein 85005
muscarinic acetylcholine receptor M17007
Glucocorticoid receptor08114
Glycine receptor subunit alpha-10808
Glycine receptor subunit beta0808
Glycine receptor subunit alpha-20808
Glycine receptor subunit alpha-30808
Potassium voltage-gated channel subfamily A member 10011
Multidrug and toxin extrusion protein 10202
nuclear receptor subfamily 1, group I, member 3100010
cytochrome P450 2D6 isoform 15005
cellular tumor antigen p53 isoform a3003
cytochrome P450 2C19 precursor3003
huntingtin isoform 21001
atrial natriuretic peptide receptor 2 precursor1001
chaperonin GroEL1001
Polyunsaturated fatty acid lipoxygenase ALOX15B6006
Sodium-dependent noradrenaline transporter0101
Voltage-dependent calcium channel gamma-2 subunit8008
Prostaglandin G/H synthase 10304
Aldo-keto reductase family 1 member B1011011
Muscarinic acetylcholine receptor M20505
Muscarinic acetylcholine receptor M40303
Muscarinic acetylcholine receptor M10415
Muscarinic acetylcholine receptor M30415
Muscarinic acetylcholine receptor M40415
5-hydroxytryptamine receptor 2C08210
Muscarinic acetylcholine receptor M50415
Muscarinic acetylcholine receptor M50404
Muscarinic acetylcholine receptor M20415
Glycogen phosphorylase, brain form0101
Glycogen phosphorylase, muscle form0101
Muscarinic acetylcholine receptor M10606
Angiotensin-converting enzyme0303
5-hydroxytryptamine receptor 2A010212
Glutamate receptor 28008
Muscarinic acetylcholine receptor M30505
Endothelin receptor type B0202
UDP-glucuronosyltransferase 1A40002
Sodium-dependent noradrenaline transporter 011011
Endothelin receptor type B0202
Histamine H2 receptor0808
5-hydroxytryptamine receptor 2B08210
Sodium-dependent serotonin transporter010010
5-hydroxytryptamine receptor 7 0404
5-hydroxytryptamine receptor 2C 0303
5-hydroxytryptamine receptor 70404
Histamine H1 receptor0718
UDP-glucuronosyltransferase 1A30001
Histamine H2 receptor80010
D(2) dopamine receptor0101
Potassium voltage-gated channel subfamily H member 20808
Sodium-dependent serotonin transporter0101
Nuclear receptor subfamily 3 group C member 3 0202
Histone-lysine N-methyltransferase SETD70202
Transporter0101
Chain A, 2-oxoglutarate Oxygenase5005
hypoxia-inducible factor 1 alpha subunit7007
Matrix metalloproteinase-90101
Inositol monophosphatase 12002
Isocitrate lyase0101
SMAD family member 24004
GALC protein5005
SMAD family member 34004
nuclear receptor subfamily 1, group I, member 25005
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
Solute carrier family 22 member 30101
Solute carrier family 22 member 20101
Gamma-aminobutyric acid 0112
glp-1 receptor, partial6006
Gamma-aminobutyric acid receptor subunit pi0404
Gamma-aminobutyric acid receptor subunit delta0404
Voltage-dependent L-type calcium channel subunit alpha-1F0303
Fatty acid-binding protein, liver0202
Alpha-1-acid glycoprotein 10001
Albumin0124
Albumin0033
Gamma-aminobutyric acid receptor subunit alpha-10202
Gamma-aminobutyric acid receptor subunit beta-10202
Neuronal acetylcholine receptor subunit alpha-40202
Gamma-aminobutyric acid receptor subunit alpha-20202
Gamma-aminobutyric acid receptor subunit alpha-30202
Neuronal acetylcholine receptor subunit beta-20202
Gamma-aminobutyric acid receptor subunit alpha-10437
Gamma-aminobutyric acid receptor subunit alpha-60112
Gamma-aminobutyric acid receptor subunit beta-10415
Gamma-aminobutyric acid receptor subunit gamma-20426
Gamma-aminobutyric acid receptor subunit alpha-40202
Gamma-aminobutyric acid receptor subunit gamma-20202
Gamma-aminobutyric acid receptor subunit gamma-20112
Gamma-aminobutyric acid receptor subunit delta0112
Gamma-aminobutyric acid receptor subunit alpha-20112
Gamma-aminobutyric acid receptor subunit alpha-30112
Gamma-aminobutyric acid receptor subunit gamma-30112
Gamma-aminobutyric acid receptor subunit beta-30426
Translocator protein0101
Translocator protein0101
Cholecystokinin receptor type A0101
Gastrin/cholecystokinin type B receptor0101
Gamma-aminobutyric acid receptor subunit alpha-50437
Gamma-aminobutyric acid receptor subunit alpha-30426
Gamma-aminobutyric acid receptor subunit alpha-20426
Gamma-aminobutyric acid receptor subunit beta-20426
Gamma-aminobutyric acid receptor subunit alpha-40415
Gamma-aminobutyric acid receptor subunit beta-10112
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit beta-30112
Gamma-aminobutyric acid receptor subunit epsilon0404
Voltage-dependent L-type calcium channel subunit alpha-1D 0303
Neuronal acetylcholine receptor subunit alpha-70101
Voltage-dependent L-type calcium channel subunit alpha-1S0303
Voltage-dependent L-type calcium channel subunit alpha-1C0303
Gamma-aminobutyric acid receptor subunit alpha-60415
Gamma-aminobutyric acid receptor subunit alpha-50112
Gamma-aminobutyric acid receptor subunit gamma-10404
Gamma-aminobutyric acid receptor subunit pi0112
Sphingosine-1-phosphate lyase 10101
Gamma-aminobutyric acid receptor subunit gamma-30404
Gamma-aminobutyric acid receptor subunit alpha-40112
Gamma-aminobutyric acid receptor subunit theta0112
Gamma-aminobutyric acid receptor subunit gamma-10112
Gamma-aminobutyric acid receptor subunit theta0404
Chain A, JmjC domain-containing histone demethylation protein 3A3003
Luciferase5005
15-lipoxygenase, partial5005
Smad32002
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)5005
67.9K protein2002
Histone H2A.x3003
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
serine/threonine-protein kinase PLK12002
histone-lysine N-methyltransferase 2A isoform 2 precursor2002
high affinity choline transporter 1 isoform a0101
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
neuropeptide S receptor isoform A5005
Nuclear receptor subfamily 1 group I member 20123
Carbonic anhydrase 10303
Carbonic anhydrase 20404
Estrogen receptor0415
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Integrin beta-32002
Tyrosine-protein kinase Fyn0101
Integrin alpha-IIb2002
Polyunsaturated fatty acid 5-lipoxygenase0101
Adenosine receptor A30404
Polyunsaturated fatty acid lipoxygenase ALOX150202
Alpha-1B adrenergic receptor010212
Substance-K receptor0404
Acetylcholinesterase0202
Prostaglandin G/H synthase 10202
Adenosine receptor A2a0202
Adenosine receptor A10505
Mu-type opioid receptor010314
Delta-type opioid receptor08211
Kappa-type opioid receptor06310
Alpha-1A adrenergic receptor011213
Nuclear receptor ROR-gamma4004
Estrogen-related receptor gamma0011
Disintegrin and metalloproteinase domain-containing protein 171001
Sodium-dependent dopamine transporter 0606
Aldehyde oxidase0101
UDP-glucose 4-epimerase0101
Mitogen-activated protein kinase 140101
Estrogen receptor beta0415
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Cysteinyl leukotriene receptor 10202
Beta-2 adrenergic receptor0303
Beta-3 adrenergic receptor0112
Opioid receptor, delta 1b 0101
Opioid receptor homologue0101
Proenkephalin-B0011
Delta-type opioid receptor0426
Kappa-type opioid receptor0203
Mu-type opioid receptor0426
Kappa-type opioid receptor0325
Mu-type opioid receptor0203
Mu-type opioid receptor0516
Mu-type opioid receptor0101
Gamma-aminobutyric acid receptor subunit rho-30011
Hsf1 protein0011
Bloom syndrome protein isoform 14004
Histone deacetylase 30303
Gamma-aminobutyric acid type B receptor subunit 20011
Gamma-aminobutyric acid type B receptor subunit 20101
Sodium- and chloride-dependent GABA transporter 10202
Gamma-aminobutyric acid receptor subunit rho-10022
Gamma-aminobutyric acid receptor subunit rho-20011
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0101
Sodium- and chloride-dependent GABA transporter 20202
Sodium- and chloride-dependent GABA transporter 30202
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent betaine transporter0202
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Histone deacetylase 40303
4-aminobutyrate aminotransferase, mitochondrial0001
4-aminobutyrate aminotransferase, mitochondrial0001
Histone deacetylase 10303
Sterol O-acyltransferase 10011
Proton-coupled amino acid transporter 10101
Histone deacetylase 70303
Histone deacetylase 20303
Polyamine deacetylase HDAC100303
Histone deacetylase 11 0303
Histone deacetylase 80303
Platelet glycoprotein VI0011
Sodium- and chloride-dependent GABA transporter 20101
Histone deacetylase 60303
Gamma-aminobutyric acid type B receptor subunit 10011
Histone deacetylase 90303
Histone deacetylase 50303
Gamma-aminobutyric acid type B receptor subunit 10101
Thrombopoietin2002
caspase 7, apoptosis-related cysteine protease1001
nonstructural protein 14004
glucocerebrosidase3003
caspase-31001
Adenylate cyclase type 1 0101
cytochrome P450 2C9 precursor5005
transient receptor potential cation channel subfamily V member 11001
Cocaine esterase0202
Solute carrier family 22 member 1 0303
Transient receptor potential cation channel subfamily V member 10101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
UDP-glucuronosyltransferase 1A90103
Potassium channel subfamily K member 20101
Major prion protein0011
Vitamin D-binding protein0101
HLA class I histocompatibility antigen, A alpha chain 0011
Integrin beta-10101
Integrin alpha-40101
Carbonyl reductase [NADPH] 10001
UDP-glucuronosyltransferase 2B70204
Beta-1 adrenergic receptor0101
D(2) dopamine receptor0303
D(4) dopamine receptor0428
D(1B) dopamine receptor0203
Adenylate cyclase type 30101
Alpha-1D adrenergic receptor0628
Sodium-dependent dopamine transporter0202
5-hydroxytryptamine receptor 3A0202
Adenosine receptor A10202
Adenylate cyclase type 20101
Adenylate cyclase type 40101
5-hydroxytryptamine receptor 1D0202
5-hydroxytryptamine receptor 1F0202
Histamine H1 receptor0202
Sodium-dependent serotonin transporter0101
C-8 sterol isomerase0101
Alpha-1A adrenergic receptor0101
5-hydroxytryptamine receptor 2A0202
Alpha-1B adrenergic receptor0101
Glutamate receptor ionotropic, NMDA 1 0112
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0101
Adenylate cyclase type 80101
5-hydroxytryptamine receptor 2A0101
D(1A) dopamine receptor2103
5-hydroxytryptamine receptor 70303
Cytochrome P450 2J20303
D(2) dopamine receptor0101
D(3) dopamine receptor0101
Gastrin/cholecystokinin type B receptor0101
AP-2 complex subunit sigma0101
N-acetyltransferase Eis0202
Glutamate receptor ionotropic, NMDA 2A 0101
Glutamate receptor ionotropic, NMDA 2B0101
Glutamate receptor ionotropic, NMDA 2C0101
Sodium channel protein type 7 subunit alpha0101
5-hydroxytryptamine receptor 2B0202
Adenylate cyclase type 60101
Adenylate cyclase type 50101
5-hydroxytryptamine receptor 40101
Sodium channel protein type 5 subunit alpha0101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Sodium channel protein type 9 subunit alpha0101
Calcitonin gene-related peptide type 1 receptor0101
Genome polyprotein 0202
Sigma intracellular receptor 20101
Sigma intracellular receptor 20202
Sigma non-opioid intracellular receptor 10314
Zinc finger protein 6640101
Glutamate receptor ionotropic, NMDA 2D0101
Vesicular acetylcholine transporter0202
Cholecystokinin receptor type A0101
Protease 0202
Adenylyl cyclase 7 0101
Glutamate receptor ionotropic, NMDA 3B0101
D0101
Sodium channel protein type 2 subunit alpha0101
Sigma non-opioid intracellular receptor 10404
Transient receptor potential cation channel subfamily V member 40101
Sodium channel protein type 3 subunit alpha0101
Sigma non-opioid intracellular receptor 10303
Glutamate receptor ionotropic, NMDA 3A0101
Sodium channel protein type 11 subunit alpha0101
Sodium channel protein type 8 subunit alpha0101
Transient receptor potential cation channel subfamily V member 20101
Sodium channel protein type 10 subunit alpha0101
Chain A, membrane-associated prostaglandin E synthase-20101
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
Chain A, Cruzipain1001
Parkin1001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
ras-related protein Rab-9A2002
DNA polymerase kappa isoform 13003
Prostaglandin-H2 D-isomerase0101
Prostaglandin E synthase0101
Solute carrier family 22 member 60101
Prostaglandin G/H synthase 1 0203
Prostaglandin G/H synthase 2 0203
3',5'-cyclic-AMP phosphodiesterase 0202
Solute carrier organic anion transporter family member 2B1 0202
Cytochrome c oxidase subunit 20101
Epidermal growth factor receptor0101
Phospholipase A2, major isoenzyme0202
Procathepsin L0101
Interleukin-80101
Polyunsaturated fatty acid 5-lipoxygenase0203
Aldo-keto reductase family 1 member B10101
Aldo-keto reductase family 1 member B10101
Aldo-keto reductase family 1 member C40101
Prostaglandin G/H synthase 10101
Serum paraoxonase/arylesterase 10101
Indoleamine 2,3-dioxygenase 10101
Caspase-10001
Nitric oxide synthase, inducible0101
Adenosine receptor A2a0101
Substance-P receptor0101
Prostaglandin E2 receptor EP3 subtype0101
Prostaglandin E2 receptor EP4 subtype0101
Multidrug resistance-associated protein 1 0101
Bifunctional epoxide hydrolase 20101
Prostaglandin G/H synthase 20314
Prostaglandin G/H synthase 2 0101
Prostaglandin E2 receptor EP1 subtype0101
Peroxisome proliferator-activated receptor gamma02710
Aldo-keto reductase family 1 member C30202
C-X-C chemokine receptor type 30101
Aldo-keto reductase family 1 member C2 0101
Prostaglandin D2 receptor 0202
Solute carrier organic anion transporter family member 1A30103
Prostaglandin G/H synthase 20202
Lactoylglutathione lyase0101
Aldo-keto reductase family 1 member C10101
Prostaglandin G/H synthase 20102
Uracil nucleotide/cysteinyl leukotriene receptor0101
Solute carrier family 22 member 60101
Solute carrier family 22 member 70001
Prostaglandin E2 receptor EP2 subtype0101
Rho-associated protein kinase 20101
Prostaglandin G/H synthase 1 0101
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 80101
Dehydrogenase/reductase SDR family member 90101
P2Y purinoceptor 120101
Solute carrier organic anion transporter family member 1B30203
Cytosolic phospholipase A2 gamma0101
Prostaglandin D2 receptor 20112
Solute carrier organic anion transporter family member 1B10204
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
5-hydroxytryptamine receptor 1D0101
5-hydroxytryptamine receptor 1B0101
Histamine H1 receptor0213
5-hydroxytryptamine receptor 5A0101
Synaptic vesicular amine transporter0202
Estrogen receptor beta0101
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial0101
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial0202
Cytochrome P450 26A10101
Bile salt export pump0303
Camphor 5-monooxygenase0001
Chymotrypsinogen A0101
Beta-lactamase0101
Epoxide hydrolase 10001
Cytochrome P450 2C11 0101
Steroid 21-hydroxylase0101
Cytochrome P450 2C80202
Steroid 17-alpha-hydroxylase/17,20 lyase 0101
Cholesterol side-chain cleavage enzyme, mitochondrial 0101
Indoleamine 2,3-dioxygenase 10101
Cytochrome P450 2A20101
Cytochrome P450 11B1, mitochondrial 0202
Cytochrome P450 11B1, mitochondrial0202
Cytochrome P450 7A1 0101
Cytochrome P450 11B2, mitochondrial0202
Estrogen receptor0101
UDP-glucuronosyltransferase 1A1 0202
Gonadotropin-releasing hormone receptor0112
Type-1 angiotensin II receptor0101
Malate dehydrogenase, cytoplasmic0101
Cytochrome P450 4F20101
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial0101
Sodium/bile acid cotransporter0202
Lanosterol 14-alpha demethylase0314
Cytochrome P450 7A10101
Lanosterol 14-alpha demethylase 0202
Beta-2 adrenergic receptor0202
Cytochrome P450 2B60101
Mas-related G-protein coupled receptor member X20011
Aldehyde oxidase 1 0101
Nuclear receptor subfamily 1 group I member 20011
5-hydroxytryptamine receptor 3E0011
5-hydroxytryptamine receptor 3B0011
Myeloperoxidase0101
5-hydroxytryptamine receptor 3A0202
5-hydroxytryptamine receptor 3A0011
6-phosphogluconate dehydrogenase, decarboxylating0101
Lactoperoxidase0101
5-hydroxytryptamine receptor 4 0102
5-hydroxytryptamine receptor 3D0011
5-hydroxytryptamine receptor 3C0011
5-hydroxytryptamine receptor 3B0101
5-hydroxytryptamine receptor 3B0202
importin subunit beta-1 isoform 11001
snurportin-11001
GTP-binding nuclear protein Ran isoform 11001
Chain A, TYROSYL-DNA PHOSPHODIESTERASE5005
Cytochrome P450 11B1, mitochondrial0101
Caspase-71001
serine-protein kinase ATM isoform a1001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
caspase-31001
nuclear factor NF-kappa-B p105 subunit isoform 11001
lethal(3)malignant brain tumor-like protein 1 isoform I1001
Peroxisome proliferator-activated receptor alpha1214
Rap guanine nucleotide exchange factor 42002
Histidine decarboxylase0011
Beta-2 adrenergic receptor0101
UDP-glucuronosyltransferase 1A80001
interferon gamma precursor0001
Somatostatin receptor type 10101
Somatostatin receptor type 20101
Somatostatin receptor type 40101
Somatostatin receptor type 30101
Somatostatin receptor type 50101
luciferase0001
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Glutamine synthetase0011
Nociceptin receptor0011
Glucose-6-phosphate 1-dehydrogenase0101
Chain A, PUTRESCINE-BINDING PROTEIN0011
Chain A, S-ADENOSYLMETHIONINE DECARBOXYLASE ALPHA CHAIN0101
Chain B, S-ADENOSYLMETHIONINE DECARBOXYLASE BETA CHAIN0101
Chain A, S-ADENOSYLMETHIONINE DECARBOXYLASE ALPHA CHAIN0101
Chain B, S-ADENOSYLMETHIONINE DECARBOXYLASE BETA CHAIN0101
Ornithine decarboxylase1102
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0202
S-adenosylmethionine decarboxylase proenzyme0001
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0202
DNA polymerase III, partial1001
alpha-galactosidase1001
NPC intracellular cholesterol transporter 1 precursor1001
ubiquitin-conjugating enzyme E2 N0101
pyruvate kinase PKM isoform b1001
Diacylglycerol kinase alpha0101
CDGSH iron-sulfur domain-containing protein 10101
thyrotropin-releasing hormone receptor1001
Free fatty acid receptor 10011
Glutamate receptor ionotropic, NMDA 2D0011
Glutamate receptor ionotropic, NMDA 3B0011
Tyrosine-protein phosphatase non-receptor type 10101
Carnitine O-palmitoyltransferase 2, mitochondrial0101
Amine oxidase [flavin-containing] B0101
Cytochrome P450 3A50011
Amine oxidase [flavin-containing] A 0101
Amine oxidase [flavin-containing] A0101
Catechol O-methyltransferase0011
Peroxisome proliferator-activated receptor alpha0112
Carnitine O-palmitoyltransferase 2, mitochondrial0101
Amine oxidase [flavin-containing] B0202
Peroxisome proliferator-activated receptor gamma0011
C-C chemokine receptor type 20101
Cannabinoid receptor 20011
Carnitine O-palmitoyltransferase 1, liver isoform0101
Peroxisome proliferator-activated receptor delta0213
Glutamate receptor ionotropic, NMDA 10011
ATP-binding cassette sub-family C member 80101
Glutamate receptor ionotropic, NMDA 2A0011
Glutamate receptor ionotropic, NMDA 2B0011
ATP-sensitive inward rectifier potassium channel 110101
Glutamate receptor ionotropic, NMDA 2C0011
Thrombin 0011
CDGSH iron-sulfur domain-containing protein 20101
Glutamate receptor ionotropic, NMDA 3A0011
CDGSH iron-sulfur domain-containing protein 10202
Carbonic anhydrase 120202
Carbonic anhydrase 30101
DNA topoisomerase 2-alpha0101
Pyruvate kinase PKM0101
Cannabinoid receptor 10101
Carbonic anhydrase 40101
Carbonic anhydrase 60101
Carbonic anhydrase 5A, mitochondrial0101
Carbonic anhydrase 70101
Sulfate anion transporter 10001
Carbonic anhydrase 90202
Carbonic anhydrase 150101
Carbonic anhydrase 130101
Carbonic anhydrase 140101
Carbonic anhydrase 5B, mitochondrial0101
polyadenylate-binding protein 10101
Tyrosine-protein kinase ABL10101
Tyrosine-protein kinase ABL20101
Chain X, Thyroid hormone receptor beta-10022
Chain X, Thyroid hormone receptor beta-10022
apical membrane antigen 1, AMA12002
DNA polymerase eta isoform 11001
Solute carrier organic anion transporter family member 1A40103
Solute carrier organic anion transporter family member 1A50002
Rap guanine nucleotide exchange factor 31001
Transthyretin0103
Thyroid hormone receptor alpha0235
Thyroid hormone receptor beta0235
Proliferating cell nuclear antigen0202
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20002
Solute carrier organic anion transporter family member 4C10102
Monocarboxylate transporter 80001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
Prothrombin0011
Thyroid hormone receptor beta0101
Solute carrier organic anion transporter family member 4C10001
Solute carrier organic anion transporter family member 4A10001
Solute carrier organic anion transporter family member 1C10101
Cytochrome P450 2A60101
Tissue factor0101
Aldo-keto reductase family 1 member A10101
UDP-glucuronosyltransferase 1-60001
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member B70101
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]