Page last updated: 2024-08-24

triazoles and Chagas Disease

triazoles has been researched along with Chagas Disease in 96 studies

Research

Studies (96)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (1.04)	18.7374
1990's	7 (7.29)	18.2507
2000's	12 (12.50)	29.6817
2010's	60 (62.50)	24.3611
2020's	16 (16.67)	2.80

Authors

Authors	Studies
Bello, ML; Campos, VR; da Silva, FC; Faria, AFM; Faria, RX; Ferreira, VF; Forezi, LDSM; Galvão, RMS; Ji, KNK; Petzold Pauli, F; Resende, JALC; Silva, TB	1
Boechat, N; Castelo-Branco, FS; França, RRF; Hoelz, LVB; Menozzi, CAC	1
Andricopulo, AD; Brasil, BFAB; Brondani, D; Cenci, AR; Chipoline, IC; de Oliveira, AS; Ferreira, LLG; Krogh, R; Nascimento, V; Neto, JSS; Teixeira, KF; Valli, M; Zapp, E	1
Abbasi Shiran, J; Ghanbari, M; Mohammadnejadi, E; Razzaghi-Asl, N	1
Aziz, N; Barnes, W; Barrett, MP; Chen, YL; Cheung, H; Cortopassi, WA; Deniston, C; Diagana, TT; Francisco, AF; Gable, JE; Ghafar, NA; Gould, MK; Jiricek, J; Johnson, N; Jumani, RS; Kaiser, M; Kelly, JM; Lakshminarayana, SB; Luu, C; Manjunatha, UH; Manoharan, V; Mäser, P; Mottram, JC; Myburgh, E; Ng, PS; Noeske, J; Osborne, C; Palkar, R; Patra, D; Rao, SPS; René, O; Ritchie, R; Saldivia, M; Sarko, C; Schenk, AD; Schmidt, RS; Thomas, B; Wagner, J; Walker, J; Wan, KF; Wartchow, C; Wiedemar, N	1
Caldas, IS; Carvalho, DT; de Souza, TB; Dias, DF; Paula, FR; Rodrigues, CC	1
Díaz, ML; Echeverría, LE; Eduardo Nieto, J; González, CI; Hernandez, JCM; López-Romero, LA; Morillo, CA; Ochoa, SAG; Rivera, JD; Rojas, LZ; Suárez, EU	1
Bahia, MT; Caldas, IS; Diniz, LF; Machado, YA; Marques, MJ; Martins-Filho, OA; Mazzeti, AL; Novaes, RD; Santos, LJS; Vilas Boas, BR	1
Au, HYA; Bhattacharyya, T; Chatelain, E; Franco, CH; Freitas-Junior, LH; Giardini, MA; Le, H; Madeira, RP; Miles, MA; Moraes, CB; Pascoalino, BS; Romera, LMD; Schenkman, S; Torrecilhas, AC; Warhurst, DC	1
Braissant, O; Fesser, AF; Kaiser, M; Kelly, JM; Mäser, P; Olmo, F	1
Bardach, A; Barreira, F; Ciapponi, A; Gascón, J; Molina, I; Morillo, C; Perelli, L; Prado, N; Riarte, A; Ribeiro, I; Sosa-Estani, S; Torrico, F; Villar, JC	1
Calvet, CM; Hirata, K; McKerrow, JH; Silva, TA; Siqueira-Neto, JL; Suzuki, B; Thomas, D	1
Hata, K	1
Almeida, IC; Alonso-Vega, C; Barboza, T; Barreira, F; Bilbe, G; Blum, B; Correia, E; Garcia, W; Gascón, J; Ortiz, L; Parrado, R; Ramirez, JC; Ribeiro, I; Sosa-Estani, S; Strub-Wourgaft, N; Torrico, F; Vaillant, M	1
Dalhatou, S; Ferreira, EI; Katata-Seru, LM; Paumo, HK; Pone, KB	1
Bahia, MT; de Castro, KCMP; Mazzeti, AL; Mendes, PF; Mosqueira, VCF; Spósito, PÁ; Urbina, JA	1
Caballero, AB; Esteban-Parra, GM; Méndez-Arriaga, JM; Salas, JM	1
Urbina, JA	3
Carvalho, I; Chierrito, TPC; de Andrade, P; Figueredo, AS; Mantoani, SP	1
Bakshi, TS; Brand, S; Crouch, SD; De Rycker, M; Epemolu, O; Fiandor, JM; Francisco, AF; Gilbert, IH; Hill, AP; Hindley, SJ; Jansen, C; Jayawardhana, S; Kelly, JM; Ko, EJ; MacLean, L; Marco, M; Miles, TJ; Nixon, CJ; Osuna-Cabello, M; Read, KD; Reid, IH; Riley, J; Robinson, SA; Sandberg, L; Scullion, P; Shishikura, Y; Simeons, FRC; Smith, VC; Spinks, D; Stojanovski, L; Thomas, J; Thomas, M; Thompson, S; Underwood, TZ; Viayna, E; Wyatt, PG	1
Campos, MC; Clark, TG; Francisco, AF; Kelly, JM; Lewis, MD; Pain, A; Phelan, J; Taylor, MC	1
Alonso-Vega, C; Alves, F; Curto, MA; de la Barra, A; Flevaud, L; García, L; Gascón, J; Irazu, L; Molina, I; Ortiz, L; Parrado, R; Ramírez, JC; Ribeiro, I; Rodríguez, M; Schijman, AG; Sulleiro, E; Torrico, F; Villarroel, S	1
Almeida, IC; Alonso-Vega, C; Alves, F; Gascon, J; Ortiz, L; Pinazo, MJ; Ribeiro, I; Schijman, A; Strub-Wourgaft, N; Torrico, F	1
da Silva, FC; Faria, RX; Ferreira, VF; Gonzaga, DTG; Pacheco, PAF; Souza, ALA	1
Cardona-G, W; Herrera-R, A; Yepes, AF	1
Figueirêdo, CBM; Lee, PI; Nadvorny, D; Rolim Neto, PJ; Schver, GCRM; Soares Sobrinho, JL; Soares, MFR; Vieira, ACQM	1
Bastos, MM; Batista, DDGJ; Bianco, MDCAD; Boechat, N; da Gama, ANS; da Silva, CF; da Silva, PB; de Oliveira, AP; Fontes, FV; Hoelz, LVB; Leite, DI; Peres, RB; Soeiro, MNC; Villar, JDF	1
Cotillo, I; De Rycker, M; Gray, DW; Lewis, MD; MacLean, LM; Thomas, J	1
Alonso-Vega, C; Alves, F; de la Barra, A; Flevaud, L; Garcia, L; Gascon, J; Illanes, D; Juiz, N; Ortiz, L; Parrado, R; Ramirez, JC; Ribeiro, I; Schijman, AG; Torrico, F	1
Aiub, CA; Araújo, JS; Batista, Dda G; Batista, MM; Britto, C; da Silva, CF; da Silva, PB; de Souza, EM; Hargrove, TY; Kim, K; Lepesheva, GI; Lionel, J; Pavão, BP; Soeiro, Mde N; Sulikowski, G; Waterman, MR	1
Bahia, MT; Caldas, IS; de Andrade, IM; Diniz, Lde F; Martins, TA; Mazzeti, AL; Ribeiro, I; Talvani, A; Urbina, JA	1
Alexander, PW; Chaplin, JH; Charman, SA; Chatelain, E; Hargrove, TY; Keenan, M; Lepesheva, GI; Perez, CJ; Waterman, MR; Wawrzak, Z	1
Andriani, G; Ashworth, R; Bloomer, WD; Kaiser, M; Papadopoulou, MV; Rodriguez, A; Rosenzweig, HS; Wilkinson, SR	1
Aiub, CA; Bastos, MM; Boechat, N; Carvalho, AS; Felzenszwalb, I; Mello, FV	1
Blanco-Grau, A; Cabezos, J; Gómez i Prat, J; Molina, I; Pahissa, A; Pou, D; Roure, S; Salvador, F; Sánchez-Montalvá, A; Serre, N; Sulleiro, E; Treviño, B; Valerio, L; Vidal, X	1
Albajar-Viñas, P; Dias, JC	1
Caballero, AB; Gutiérrez-Sánchez, R; Marín, C; Ramírez-Macías, I; Rodríguez-Diéguez, A; Salas, JM; Sánchez-Moreno, M; Santamaría-Díaz, N	1
Caballero, AB; Chaves-Lemaur, G; Gutierrez-Sánchez, R; Huertas, Ó; Marín, C; Olmo, F; Quirós, M; Ramírez-Macías, I; Rodríguez-Diéguez, A; Salas, JM; Sánchez-Moreno, M	1
Molina, I; Salvador, F; Sánchez-Montalvá, A	2
Marin-Neto, JA; Rassi, A	1
Bestetti, RB; Restini, CB	1
Bloomer, WD; Kaiser, M; Papadopoulou, MV; Rosenzweig, HS; Wilkinson, SR	1
Fügi, MA; Guan, XL; Kaiser, M; Mäser, P; Schneiter, R; Tanner, M	1
Aguilera-Venegas, B; Bloomer, WD; Chatelain, E; Ioset, JR; Kaiser, M; Lepesheva, GI; Papadopoulou, MV; Rosenzweig, HS; Wilkinson, SR	1
Benaim, G; de Carvalho, TM; de Souza, W; Docampo, R; Galizzi, M; Gonzalez-Pacanowska, D; Guo, RT; Hernandez-Rodriguez, V; Huang, G; Lameira, L; Li, K; Li, Q; Oldfield, E; Shang, N; Urbina, JA; Veiga-Santos, P	1
Chatelain, E; Francisco, AF; Jayawardhana, S; Kelly, JM; Lewis, MD; Taylor, MC	2
Glynne, R; Groessl, T; Khare, S; Liu, X; Molteni, V; Rivera, I; Stinson, M; Supek, F; Tuntland, T; Wen, B; Yeh, V	1
Bloomer, WD; Chatelain, E; Ioset, JR; Kaiser, M; O'Shea, IP; Papadopoulou, MV; Rosenzweig, HS; Wilkinson, SR	1
Bloomer, WD; Kaiser, M; O'Shea, IP; Papadopoulou, MV; Rosenzweig, HS; Wilkinson, SR	1
McKerrow, JH; Urbina, JA	1
Asada, M	1
Ballard, J; Barnes, SW; Biggart, A; Brock, A; Buckner, FS; Bursulaya, B; Davis, LC; Federe, G; Gao, MY; Gillespie, JR; Glynne, RJ; Groessl, T; Khare, S; Koh, HX; Lai, YH; Liang, F; Liu, X; Mathison, CJ; Mishra, PK; Molteni, V; Mottram, JC; Myburgh, E; Nagle, AS; Rao, SP; Rivera, IC; Shapiro, M; Spraggon, G; Stinson, M; Supek, F; Tan, JL; Tuntland, T; Venable, JD; Walker, JR; Wen, BG; Yeh, V	1
Bern, C	1
Apt, W; Beloscar, J; Bonilla, LR; Colombo, H; Cuneo, C; Del Carmen Bangher, M; Echeverria, LE; Gao, P; Gascon, J; Mallagray, M; McCarthy, M; Meeks, B; Milesi, R; Molina, I; Morillo, CA; Perez-Molina, JA; Sosa-Estani, S; Waskin, H; Wei, B; Wyss, F; Yusuf, S	1
Bahia, MT; Bloomer, WD; Gonçalves, KR; Mazzeti, AL; Mendes, PF; Papadopoulou, MV; Rosenzweig, HS	1
Alves, RO; Ferraz, ML; Gazzinelli, RT; Romanha, AJ; Urbina, JA	2
Moloney, A	1
Ang, K; Barrett, KT; Brak, K; Brinen, LS; Debnath, M; Doyle, PS; Ellman, JA; Engel, JC; Fuchi, N; Kerr, ID; McKerrow, JH	1
Espinosa, G; Gállego, M; Gascón, J; López-Chejade, PL; Pinazo, MJ; Urbina, JA	1
Bahia, MT; Caldas, IS; Carneiro, CM; Crepalde, G; de Lana, M; Diniz, Lde F; Guedes, PM; Talvani, A; Urbina, JA	1
Araújo-Jorge, TC; Calvet, CM; de Castro, SL; Molina, JT; Olivieri, BP; Pereira, MC; Urbina, JA	1
Anderson, S; Furtak, V; Hargrove, TY; Kleshchenko, Y; Lepesheva, GI; Villalta, F; Waterman, MR; Wawrzak, Z	1
Clayton, J	1
Alviano, CS; Alviano, DS; Atella, GC; Folly, E; Gomes, MT; Lopes, AH; Silva-Filho, FC; Zimmermann, LT	1
Barea, E; Caballero, AB; Marín, C; Ramírez-Macías, I; Rodríguez-Diéguez, A; Salas, JM; Sánchez-Moreno, M	1
Lepesheva, GI; Villalta, F; Waterman, MR	1
Le Loup, G; Lescure, FX; Pialoux, G	1
Bloomer, WD; Brun, R; Kaiser, M; McKenzie, C; Papadopoulou, MV; Prasittichai, C; Torreele, E; Trunz, BB; Wilkinson, SR	1
Albesa, I; Becerra, MC; Gea, S; Guiñazú, N; Hergert, LY; Mazzieri, MR; Pellegrini, A	1
Benaim, B; Garcia, CR	1
Bahia, MT; Buckner, FS; Charman, SA; Chatelain, E; Chennamaneni, NK; Gelb, MH; Hulverson, MA; Laydbak, JU; Lepesheva, GI; Scandale, I; Shackleford, DM; Suryadevara, PK; Verlinde, CL; White, KL	1
Carlier, Y; Cencig, S; Coltel, N; Truyens, C	1
Barrett, MP; Croft, SL	1
Altcheh, J; Bournissen, FG; Cutrullis, RA; Eagleson, MA; Freilij, H; Gulin, JE; Petray, PB; Postan, M	1
Dobish, MC; Johnston, JN; Lepesheva, GI; Villalta, F; Waterman, MR	1
Aldasoro, E; Cortes-Lletget, C; Espinosa, G; Gállego, M; Gascon, J; Muñoz, J; Oliveira, I; Pinazo, MJ; Posada, Ede J	1
Lira, R; Payares, G; Romanha, AJ; Sanoja, C; Urbina, JA	1
Brener, Z; Lira, R; Molina, J; Payares, G; Romanha, AJ; Sanoja, C; Urbina, JA	1
Afonso, LC; Bahia, MT; Chiari, E; de Lana, M; Guedes, PM; Machado-Coelho, GL; Tafuri, WL; Urbina, JA; Veloso, VM	1
Basombrío, MA; Cardozo, R; Corrales, M; Segura, MA; Urbina, JA	1
Benaim, G; Burgos, JM; Caldera, AR; Colina, C; Concepcion, JL; Garcia-Marchán, Y; Leon-Rossell, A; Levin, M; Lira, R; Oldfield, E; Payares, G; Sanders, JM; Sanoja, C; Schijman, AG; Urbina, JA	1
Maldonado, RA; Molina, J; Payares, G; Urbina, JA	1
Lazardi, K; Liendo, A; Molina, J; Payares, G; Perez, N; Piras, MM; Piras, R; Ryley, JF; Sanoja, C; Urbina, JA; Wincker, P	1
Kierszenbaum, F	1
Contreras, LM; Liendo, A; Loebenberg, D; Molina, J; Payares, G; Perez, N; Piras, M; Piras, R; Sanoja, C; Urbina, JA; Wincker, P	1
Brener, Z; Loebenberg, D; Martins-Filho, O; Molina, J; Romanha, AJ; Urbina, JA	1
Brener, Z; Molina, J; Romanha, AJ; Urbina, JA	1
Brener, Z; Gref, R; Molina, J; Urbina, J	1
Bhooshan, B; Novinsion, T; Okabe, T; Revankar, GR; Robins, RK; Senga, K; Wilson, HR	1
Atienza, J; Claramunt, RM; Elguero, J; Escario, JA; Gómez Barrio, A; Mester, B	1

Reviews

14 review(s) available for triazoles and Chagas Disease

Article	Year
The Medicinal Chemistry of 3-nitro-1,2,4-triazoles: Focus on Infectious Diseases. Current topics in medicinal chemistry, 2021, Volume: 21, Issue:23 Topics: Animals; Chagas Disease; Chemistry, Pharmaceutical; Communicable Diseases; Humans; Leishmaniasis; Mycoses; Triazoles; Trypanosomiasis, African; Tuberculosis	2021
Fixed vs adjusted-dose benznidazole for adults with chronic Chagas disease without cardiomyopathy: A systematic review and meta-analysis. PLoS neglected tropical diseases, 2020, Volume: 14, Issue:8 Topics: Adult; Cardiomyopathies; Chagas Disease; Databases, Factual; Humans; Nifurtimox; Nitroimidazoles; Patient Safety; Randomized Controlled Trials as Topic; Treatment Outcome; Triazoles; Trypanosoma cruzi	2020
Leishmanicidal and Trypanocidal Activity of Metal Complexes with 1,2,4-Triazolo[1,5-a]pyrimidines: Insights on their Therapeutic Potential against Leishmaniasis and Chagas Disease. Current medicinal chemistry, 2017, Volume: 24, Issue:25 Topics: Animals; Antiprotozoal Agents; Chagas Disease; Coordination Complexes; Humans; Leishmania; Leishmaniasis; Microbial Sensitivity Tests; Pyrimidines; Triazoles; Trypanosoma	2017
Potential Triazole-based Molecules for the Treatment of Neglected Diseases. Current medicinal chemistry, 2019, Volume: 26, Issue:23 Topics: Animals; Antiprotozoal Agents; Chagas Disease; Humans; Leishmaniasis; Malaria; Triazoles; Tuberculosis	2019
Hybrid Molecules: Promising Compounds for the Development of New Treatments Against Leishmaniasis and Chagas Disease. Current medicinal chemistry, 2018, Volume: 25, Issue:30 Topics: Antiprotozoal Agents; Chagas Disease; Chalcone; Humans; Hydrazones; Leishmaniasis; Pentamidine; Quinolines; Terpenes; Triazoles	2018
The use of posaconazole against Chagas disease. Current opinion in infectious diseases, 2015, Volume: 28, Issue:5 Topics: Animals; Chagas Disease; Disease Models, Animal; Humans; Mice; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2015
Targeting Trypanosoma cruzi sterol 14α-demethylase (CYP51). Advances in parasitology, 2011, Volume: 75 Topics: 14-alpha Demethylase Inhibitors; Antifungal Agents; Azoles; Catalytic Domain; Chagas Disease; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Humans; Protein Conformation; Substrate Specificity; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2011
Update in treatment of Chagas disease. Current opinion in infectious diseases, 2011, Volume: 24, Issue:5 Topics: Chagas Disease; Chronic Disease; Humans; Immune Tolerance; Immunocompromised Host; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2011
Targeting calcium homeostasis as the therapy of Chagas' disease and leishmaniasis - a review. Tropical biomedicine, 2011, Volume: 28, Issue:3 Topics: Amiodarone; Antiprotozoal Agents; Calcium; Chagas Disease; Homeostasis; Humans; Leishmania; Leishmaniasis; Phosphorylcholine; Triazoles; Trypanosoma brucei brucei; Trypanosoma cruzi	2011
Management of trypanosomiasis and leishmaniasis. British medical bulletin, 2012, Volume: 104 Topics: Administration, Oral; Africa; Amphotericin B; Antiprotozoal Agents; Benzamides; Boron Compounds; Chagas Disease; Drug Therapy, Combination; Humans; India; Leishmaniasis; Nitroimidazoles; Pentamidine; Triazoles; Trypanosomiasis, African	2012
Immunosuppression and Chagas disease: a management challenge. PLoS neglected tropical diseases, 2013, Volume: 7, Issue:1 Topics: Adult; Antiprotozoal Agents; Chagas Disease; Female; Humans; Immunocompromised Host; Male; Middle Aged; Nifurtimox; Nitroimidazoles; Opportunistic Infections; Triazoles; Trypanosoma cruzi	2013
Can a killer be arrested? Nature medicine, 1996, Volume: 2, Issue:10 Topics: Animals; Chagas Disease; Humans; Insect Vectors; Mice; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	1996
Chemotherapy of Chagas' disease: the how and the why. Journal of molecular medicine (Berlin, Germany), 1999, Volume: 77, Issue:3 Topics: Animals; Chagas Disease; Humans; Models, Chemical; Sterols; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	1999
Specific treatment of Chagas disease: current status and new developments. Current opinion in infectious diseases, 2001, Volume: 14, Issue:6 Topics: Chagas Disease; Cysteine Proteinase Inhibitors; Humans; Quinazolines; Triazoles	2001

Trials

5 trial(s) available for triazoles and Chagas Disease

Article	Year
New regimens of benznidazole monotherapy and in combination with fosravuconazole for treatment of Chagas disease (BENDITA): a phase 2, double-blind, randomised trial. The Lancet. Infectious diseases, 2021, Volume: 21, Issue:8 Topics: Adult; Bolivia; Chagas Disease; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Nitroimidazoles; Parasite Load; Treatment Outcome; Triazoles; Young Adult	2021
Treatment of adult chronic indeterminate Chagas disease with benznidazole and three E1224 dosing regimens: a proof-of-concept, randomised, placebo-controlled trial. The Lancet. Infectious diseases, 2018, Volume: 18, Issue:4 Topics: Administration, Oral; Adolescent; Adult; Bolivia; Chagas Disease; Double-Blind Method; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Incidence; Male; Middle Aged; Nitroimidazoles; Parasite Load; Placebos; Polymerase Chain Reaction; Prospective Studies; Thiazoles; Treatment Outcome; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Young Adult	2018
Usefulness of Serial Blood Sampling and PCR Replicates for Treatment Monitoring of Patients with Chronic Chagas Disease. Antimicrobial agents and chemotherapy, 2019, Volume: 63, Issue:2 Topics: Adolescent; Adult; Chagas Disease; DNA, Protozoan; Humans; Middle Aged; Monitoring, Physiologic; Nitroimidazoles; Parasite Load; Placebos; Real-Time Polymerase Chain Reaction; Thiazoles; Treatment Outcome; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Young Adult	2019
Randomized trial of posaconazole and benznidazole for chronic Chagas' disease. The New England journal of medicine, 2014, May-15, Volume: 370, Issue:20 Topics: Adult; Chagas Disease; Chronic Disease; DNA, Protozoan; Female; Humans; Intention to Treat Analysis; Male; Middle Aged; Nitroimidazoles; Prospective Studies; Transaminases; Treatment Outcome; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2014
Benznidazole and Posaconazole in Eliminating Parasites in Asymptomatic T. Cruzi Carriers: The STOP-CHAGAS Trial. Journal of the American College of Cardiology, 2017, Feb-28, Volume: 69, Issue:8 Topics: Administration, Oral; Adult; Chagas Disease; Chronic Disease; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Nitroimidazoles; Prospective Studies; Single-Blind Method; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2017

Other Studies

77 other study(ies) available for triazoles and Chagas Disease

Article	Year
Synthesis and in vitro and in silico studies of 1H- and 2H-1,2,3-triazoles as antichagasic agents. Bioorganic chemistry, 2021, Volume: 116 Topics: Animals; Chagas Disease; Dose-Response Relationship, Drug; Male; Mice; Molecular Structure; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2021
Synthesis and investigation of the trypanocidal potential of novel 1,2,3-triazole-selenide hybrids. European journal of medicinal chemistry, 2022, Dec-05, Volume: 243 Topics: Chagas Disease; Humans; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2022
Structural Insight into Privileged Heterocycles as Anti- Current topics in medicinal chemistry, 2023, Volume: 23, Issue:9 Topics: Animals; Chagas Disease; Humans; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi; Trypanosomiasis, African	2023
Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections. Science (New York, N.Y.), 2023, 06-30, Volume: 380, Issue:6652 Topics: Animals; Chagas Disease; Cryoelectron Microscopy; DNA Topoisomerases, Type II; Drug Evaluation, Preclinical; Humans; Mice; Topoisomerase II Inhibitors; Triazoles; Trypanosoma; Trypanosomiasis, African	2023
Synthesis, activity, and molecular modeling studies of 1,2,3-triazole derivatives from natural phenylpropanoids as new trypanocidal agents. Chemical biology & drug design, 2020, Volume: 95, Issue:1 Topics: Animals; Biological Products; Chagas Disease; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Disease Models, Animal; Drug Design; Humans; Mice; Molecular Docking Simulation; Molecular Structure; Protozoan Proteins; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2020
Efficacy of the Benznidazole+Posaconazole combination therapy in parasitemia reduction: An experimental murine model of acute Chagas. Revista da Sociedade Brasileira de Medicina Tropical, 2020, Volume: 53 Topics: Acute Disease; Animals; Chagas Disease; Disease Models, Animal; Disease Progression; DNA, Protozoan; Drug Therapy, Combination; Nitroimidazoles; Parasite Load; Parasitemia; Rats; Rats, Wistar; Triazoles; Trypanocidal Agents	2020
Amlodipine Increases the Therapeutic Potential of Ravuconazole upon Trypanosoma cruzi Infection. Antimicrobial agents and chemotherapy, 2020, 07-22, Volume: 64, Issue:8 Topics: Amlodipine; Animals; Chagas Disease; Mice; Nitroimidazoles; Parasitemia; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2020
Novel structural CYP51 mutation in Trypanosoma cruzi associated with multidrug resistance to CYP51 inhibitors and reduced infectivity. International journal for parasitology. Drugs and drug resistance, 2020, Volume: 13 Topics: 14-alpha Demethylase Inhibitors; Animals; Cell Line; Chagas Disease; Drug Resistance, Multiple; Genes, Protozoan; Mutation; Nitroimidazoles; Sterol 14-Demethylase; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2020
Non-invasive monitoring of drug action: A new live in vitro assay design for Chagas' disease drug discovery. PLoS neglected tropical diseases, 2020, Volume: 14, Issue:7 Topics: Chagas Disease; Drug Discovery; Humans; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2020
Long term follow-up of Trypanosoma cruzi infection and Chagas disease manifestations in mice treated with benznidazole or posaconazole. PLoS neglected tropical diseases, 2020, Volume: 14, Issue:9 Topics: Administration, Oral; Animals; Chagas Disease; Disease Models, Animal; Follow-Up Studies; Male; Mice, Inbred C57BL; Nitroimidazoles; Polymerase Chain Reaction; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2020
Development of E1224 by leveraging a strategic partnership for the medicines creation against neglected tropical diseases. Parasitology international, 2021, Volume: 81 Topics: Chagas Disease; Global Health; Neglected Diseases; Thiazoles; Triazoles; Tropical Medicine; Trypanocidal Agents; Trypanosoma cruzi	2021
Triazole-containing Heterocycles: Privileged Scaffolds in Anti- Current drug targets, 2022, Volume: 23, Issue:1 Topics: Animals; Chagas Disease; Drug Development; Humans; Triazoles; Trypanosoma cruzi	2022
Higher oral efficacy of ravuconazole in self-nanoemulsifying systems in shorter treatment in experimental chagas disease. Experimental parasitology, 2021, Volume: 228 Topics: Animals; Chagas Disease; Emulsions; Female; Hep G2 Cells; Humans; Inhibitory Concentration 50; Mice; Myocytes, Cardiac; Nanostructures; Rats; Thiazoles; Triazoles; Trypanosoma cruzi	2021
Pharmacodynamics and Follow-Up Period in the Treatment of Human Trypanosoma Cruzi Infections With Posaconazole. Journal of the American College of Cardiology, 2017, 07-11, Volume: 70, Issue:2 Topics: Animals; Chagas Disease; Follow-Up Studies; Humans; Nitroimidazoles; Parasites; Triazoles	2017
Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi. Journal of medicinal chemistry, 2017, 09-14, Volume: 60, Issue:17 Topics: Amination; Animals; Chagas Disease; Chlorocebus aethiops; Drug Discovery; Female; Humans; Mice; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells	2017
Genome-wide mutagenesis and multi-drug resistance in American trypanosomes induced by the front-line drug benznidazole. Scientific reports, 2017, 10-31, Volume: 7, Issue:1 Topics: Animals; Chagas Disease; Disease Models, Animal; Drug Resistance, Multiple; Female; Genome, Protozoan; Mice, SCID; Mutagenesis; Mutagens; Mutation; Nitroimidazoles; Sequence Analysis, DNA; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2017
First external quality assurance program for bloodstream Real-Time PCR monitoring of treatment response in clinical trials of Chagas disease. PloS one, 2017, Volume: 12, Issue:11 Topics: Chagas Disease; Humans; Monitoring, Physiologic; Nitroimidazoles; Real-Time Polymerase Chain Reaction; Triazoles; Trypanocidal Agents	2017
Searching for new drugs for Chagas diseases: triazole analogs display high in vitro activity against Trypanosoma cruzi and low toxicity toward mammalian cells. Journal of bioenergetics and biomembranes, 2018, Volume: 50, Issue:2 Topics: Animals; Antiparasitic Agents; Cell Line; Chagas Disease; Humans; Macrophages, Peritoneal; Mice; Triazoles; Trypanosoma cruzi	2018
Enhanced delivery of fixed-dose combination of synergistic antichagasic agents posaconazole-benznidazole based on amorphous solid dispersions. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2018, Jul-01, Volume: 119 Topics: Biological Availability; Chagas Disease; Drug Carriers; Drug Combinations; Drug Liberation; Drug Synergism; Models, Molecular; Nitroimidazoles; Povidone; Pyrrolidines; Triazoles; Trypanocidal Agents; Vinyl Compounds	2018
New 1,2,3-triazole-based analogues of benznidazole for use against Trypanosoma cruzi infection: In vitro and in vivo evaluations. Chemical biology & drug design, 2018, Volume: 92, Issue:3 Topics: Animals; Cell Line; Cell Survival; Chagas Disease; Male; Mice; Nifurtimox; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2018
Development of Trypanosoma cruzi in vitro assays to identify compounds suitable for progression in Chagas' disease drug discovery. PLoS neglected tropical diseases, 2018, Volume: 12, Issue:7 Topics: Biological Assay; Chagas Disease; Drug Discovery; Ergosterol; Humans; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2018
In vitro and in vivo studies of the antiparasitic activity of sterol 14α-demethylase (CYP51) inhibitor VNI against drug-resistant strains of Trypanosoma cruzi. Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:9 Topics: 14-alpha Demethylase Inhibitors; Animals; Chagas Disease; Drug Resistance; Endoplasmic Reticulum; Golgi Apparatus; Imidazoles; Male; Mice; Microscopy, Electron, Transmission; Nitroimidazoles; Oxadiazoles; Protozoan Proteins; Sterol 14-Demethylase; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2013
Benznidazole and posaconazole in experimental Chagas disease: positive interaction in concomitant and sequential treatments. PLoS neglected tropical diseases, 2013, Volume: 7, Issue:8 Topics: Animals; Antiprotozoal Agents; Chagas Disease; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Female; Mice; Nitroimidazoles; Parasitemia; Treatment Outcome; Triazoles; Trypanosoma cruzi	2013
Complexes of Trypanosoma cruzi sterol 14α-demethylase (CYP51) with two pyridine-based drug candidates for Chagas disease: structural basis for pathogen selectivity. The Journal of biological chemistry, 2013, Nov-01, Volume: 288, Issue:44 Topics: 14-alpha Demethylase Inhibitors; Antiprotozoal Agents; Chagas Disease; Crystallography, X-Ray; Humans; Protozoan Proteins; Sterol 14-Demethylase; Thiazoles; Triazoles; Trypanosoma cruzi	2013
Novel 3-nitro-1H-1,2,4-triazole-based compounds as potential anti-Chagasic drugs: in vivo studies. Future medicinal chemistry, 2013, Volume: 5, Issue:15 Topics: Amides; Animals; Caco-2 Cells; Cell Line; Cell Membrane Permeability; Chagas Disease; Embryo, Nonmammalian; Humans; Organisms, Genetically Modified; Parasitic Sensitivity Tests; Rats; Structure-Activity Relationship; Sulfonamides; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Zebrafish	2013
Evaluation of genotoxic effects of new molecules with possible trypanocidal activity for Chagas disease treatment. TheScientificWorldJournal, 2013, Volume: 2013 Topics: Animals; Cell Line; Chagas Disease; DNA Damage; Humans; Micronuclei, Chromosome-Defective; Mutagenesis; Rats; Salmonella enterica; Thiadiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2013
Advancing the treatment for Chagas' disease. The New England journal of medicine, 2014, May-15, Volume: 370, Issue:20 Topics: Chagas Disease; Female; Humans; Male; Nitroimidazoles; Triazoles; Trypanocidal Agents	2014
Lanthanide complexes containing 5-methyl-1,2,4-triazolo[1,5-a] pyrimidin-7(4H)-one and their therapeutic potential to fight leishmaniasis and Chagas disease. Journal of inorganic biochemistry, 2014, Volume: 138 Topics: Animals; Antiprotozoal Agents; Chagas Disease; Chlorocebus aethiops; Coordination Complexes; Crystallography, X-Ray; Female; Inhibitory Concentration 50; Lanthanoid Series Elements; Leishmania; Leishmania braziliensis; Leishmania infantum; Leishmaniasis; Ligands; Pyrimidinones; Rats; Triazoles; Trypanosoma cruzi; Vero Cells	2014
Triazolopyrimidine compounds containing first-row transition metals and their activity against the neglected infectious Chagas disease and leishmaniasis. European journal of medicinal chemistry, 2014, Oct-06, Volume: 85 Topics: Animals; Chagas Disease; Chlorocebus aethiops; Extracellular Space; Female; Inhibitory Concentration 50; Intracellular Space; Leishmania braziliensis; Leishmania infantum; Leishmaniasis; Mice; Models, Molecular; Molecular Conformation; Organometallic Compounds; Transition Elements; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells	2014
Posaconazole versus benznidazole for chronic Chagas' disease. The New England journal of medicine, 2014, 09-04, Volume: 371, Issue:10 Topics: Chagas Disease; Female; Humans; Male; Nitroimidazoles; Triazoles; Trypanocidal Agents	2014
Posaconazole versus benznidazole for chronic Chagas' disease. The New England journal of medicine, 2014, 09-04, Volume: 371, Issue:10 Topics: Chagas Disease; Female; Humans; Male; Nitroimidazoles; Triazoles; Trypanocidal Agents	2014
Posaconazole versus benznidazole for chronic Chagas' disease. The New England journal of medicine, 2014, 09-04, Volume: 371, Issue:10 Topics: Chagas Disease; Female; Humans; Male; Nitroimidazoles; Triazoles; Trypanocidal Agents	2014
Novel nitro(triazole/imidazole)-based heteroarylamides/sulfonamides as potential antitrypanosomal agents. European journal of medicinal chemistry, 2014, Nov-24, Volume: 87 Topics: Amides; Apoptosis; Blood Platelets; Cells, Cultured; Chagas Disease; Flow Cytometry; Heterocyclic Compounds; Humans; Imidazoles; In Vitro Techniques; Leishmania donovani; Leishmaniasis, Visceral; Molecular Structure; Monocytes; Platelet Activation; Sulfonamides; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2014
Match-making for posaconazole through systems thinking. Trends in parasitology, 2015, Volume: 31, Issue:2 Topics: Chagas Disease; Clinical Trials, Phase II as Topic; Drug Therapy, Combination; Humans; Systems Biology; Triazoles; Trypanocidal Agents; Trypanosoma	2015
Novel 3-nitrotriazole-based amides and carbinols as bifunctional antichagasic agents. Journal of medicinal chemistry, 2015, Feb-12, Volume: 58, Issue:3 Topics: Amides; Animals; Cell Line; Chagas Disease; Dose-Response Relationship, Drug; Methanol; Mice; Mice, Inbred BALB C; Molecular Structure; Parasitic Sensitivity Tests; Rats; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosoma cruzi	2015
SQ109, a new drug lead for Chagas disease. Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:4 Topics: Adamantane; Animals; Chagas Disease; Ethylenediamines; Hemolysis; Humans; In Vitro Techniques; LLC-PK1 Cells; Membrane Potential, Mitochondrial; Squalene; Sterols; Swine; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2015
Limited Ability of Posaconazole To Cure both Acute and Chronic Trypanosoma cruzi Infections Revealed by Highly Sensitive In Vivo Imaging. Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:8 Topics: Animals; Antifungal Agents; Chagas Disease; Chronic Disease; Disease Models, Animal; Female; Mice; Mice, Inbred BALB C; Mice, SCID; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2015
Antitrypanosomal Treatment with Benznidazole Is Superior to Posaconazole Regimens in Mouse Models of Chagas Disease. Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:10 Topics: 14-alpha Demethylase Inhibitors; Administration, Oral; Animals; Chagas Disease; Clinical Trials, Phase II as Topic; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Heart; Humans; Immunosuppression Therapy; Mice; NIH 3T3 Cells; Nitroimidazoles; Parasitemia; Recurrence; Sterol 14-Demethylase; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2015
Discovery of potent nitrotriazole-based antitrypanosomal agents: In vitro and in vivo evaluation. Bioorganic & medicinal chemistry, 2015, Oct-01, Volume: 23, Issue:19 Topics: Animals; Binding Sites; Cell Line; Chagas Disease; Disease Models, Animal; Leishmania donovani; Mice; Mice, Inbred BALB C; Nitroreductases; Parasitic Sensitivity Tests; Prodrugs; Protein Structure, Tertiary; Protozoan Proteins; Rats; Sterol 14-Demethylase; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosoma cruzi	2015
3-Nitrotriazole-based piperazides as potent antitrypanosomal agents. European journal of medicinal chemistry, 2015, Oct-20, Volume: 103 Topics: Animals; Cell Line; Chagas Disease; Dose-Response Relationship, Drug; Humans; Leishmania donovani; Mice; Mice, Inbred BALB C; Molecular Structure; Parasitic Sensitivity Tests; Piperazines; Rats; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosoma cruzi	2015
Drug Susceptibility of Genetically Engineered Trypanosoma cruzi Strains and Sterile Cure in Animal Models as a Criterion for Potential Clinical Efficacy of Anti-T. cruzi Drugs. Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:12 Topics: Animals; Antifungal Agents; Chagas Disease; Chronic Disease; Female; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2015
Reply to "Drug Susceptibility of Genetically Engineered Trypanosoma cruzi Strains and Sterile Cure in Animal Models as a Criterion for Potential Clinical Efficacy of Anti-T. cruzi Drugs". Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:12 Topics: Animals; Antifungal Agents; Chagas Disease; Chronic Disease; Female; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2015
[Development and Distribution of Drugs for NTDs: Efforts of One Pharmaceutical Company]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2016, Volume: 136, Issue:2 Topics: Animals; Antifungal Agents; Chagas Disease; Cost-Benefit Analysis; Drug Discovery; Drug Industry; Global Health; Humans; Intersectoral Collaboration; Mice; Neglected Diseases; Prodrugs; Thiazoles; Triazoles; Tropical Medicine	2016
Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness. Nature, 2016, 09-08, Volume: 537, Issue:7619 Topics: Animals; Chagas Disease; Chymotrypsin; Disease Models, Animal; Female; Humans; Inhibitory Concentration 50; Kinetoplastida; Leishmaniasis; Mice; Molecular Structure; Molecular Targeted Therapy; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrimidines; Species Specificity; Triazoles; Trypanosomiasis, African	2016
A New Epoch in Antitrypanosomal Treatment for Chagas Disease. Journal of the American College of Cardiology, 2017, 02-28, Volume: 69, Issue:8 Topics: Animals; Chagas Disease; Nitroimidazoles; Parasites; Triazoles	2017
Nitrotriazole-Based Compounds as Antichagasic Agents in a Long-Treatment Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:5 Topics: Animals; Chagas Disease; Dose-Response Relationship, Drug; Female; Mice; Nitroimidazoles; Parasitemia; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2017
Absence of CD4+ T lymphocytes, CD8+ T lymphocytes, or B lymphocytes has different effects on the efficacy of posaconazole and benznidazole in treatment of experimental acute Trypanosoma cruzi infection. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:1 Topics: Animals; B-Lymphocytes; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chagas Disease; Male; Mice; Mice, Knockout; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2009
Trial renews interest in Chagas' disease. Lancet (London, England), 2009, Oct-31, Volume: 374, Issue:9700 Topics: Chagas Disease; Clinical Trials, Phase I as Topic; Drug Industry; Global Health; Humans; Latin America; Prodrugs; Research Support as Topic; Thiazoles; Triazoles	2009
Nonpeptidic tetrafluorophenoxymethyl ketone cruzain inhibitors as promising new leads for Chagas disease chemotherapy. Journal of medicinal chemistry, 2010, Feb-25, Volume: 53, Issue:4 Topics: Animals; Cattle; Cells, Cultured; Chagas Disease; Cysteine Endopeptidases; Female; Ketones; Macrophages; Mice; Mice, Inbred C3H; Models, Molecular; Parasitic Sensitivity Tests; Protozoan Proteins; Quinolines; Stereoisomerism; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2010
Successful treatment with posaconazole of a patient with chronic Chagas disease and systemic lupus erythematosus. The American journal of tropical medicine and hygiene, 2010, Volume: 82, Issue:4 Topics: Adult; Chagas Disease; Female; Humans; Lupus Erythematosus, Systemic; Triazoles; Trypanocidal Agents	2010
Effects of ravuconazole treatment on parasite load and immune response in dogs experimentally infected with Trypanosoma cruzi. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:7 Topics: Animals; Chagas Disease; Dogs; Enzyme-Linked Immunosorbent Assay; Immunoglobulin G; Interferon-gamma; Interleukin-10; Myocardium; Polymerase Chain Reaction; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2010
A comparative study of posaconazole and benznidazole in the prevention of heart damage and promotion of trypanocidal immune response in a murine model of Chagas disease. International journal of antimicrobial agents, 2010, Volume: 36, Issue:1 Topics: Animals; Antiprotozoal Agents; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chagas Cardiomyopathy; Chagas Disease; Disease Models, Animal; Female; Heart; Humans; Mice; Myocardium; Nitroimidazoles; Survival Analysis; Triazoles; Trypanosoma cruzi	2010
Structural insights into inhibition of sterol 14alpha-demethylase in the human pathogen Trypanosoma cruzi. The Journal of biological chemistry, 2010, Aug-13, Volume: 285, Issue:33 Topics: Animals; Antifungal Agents; Chagas Disease; Crystallography, X-Ray; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Immunoblotting; Molecular Structure; Myocytes, Cardiac; Protein Structure, Secondary; Triazoles; Trypanosoma cruzi	2010
Chagas disease: pushing through the pipeline. Nature, 2010, Jun-24, Volume: 465, Issue:7301 Topics: Adult; Animals; Chagas Disease; Child; Chronic Disease; Clinical Trials as Topic; Drug Evaluation, Preclinical; Female; Humans; Infant, Newborn; Lupus Erythematosus, Systemic; Molecular Targeted Therapy; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Young Adult	2010
Effects of platelet-activating factor on the interaction of Trypanosoma cruzi with Rhodnius prolixus. Parasitology research, 2011, Volume: 108, Issue:6 Topics: Animals; Azepines; Chagas Disease; Host-Parasite Interactions; N-Acetylneuraminic Acid; Neuraminidase; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rhodnius; Triazoles; Trypanosoma cruzi	2011
In vitro and in vivo antiparasital activity against Trypanosoma cruzi of three novel 5-methyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one-based complexes. Journal of inorganic biochemistry, 2011, Volume: 105, Issue:6 Topics: Animals; Chagas Disease; Chlorocebus aethiops; Coordination Complexes; Crystallography, X-Ray; Female; Ligands; Mice; Mice, Inbred BALB C; Microscopy, Electron, Transmission; Nitroimidazoles; Perchlorates; Pyrimidinones; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells	2011
Novel 3-nitro-1H-1,2,4-triazole-based aliphatic and aromatic amines as anti-chagasic agents. Journal of medicinal chemistry, 2011, Dec-08, Volume: 54, Issue:23 Topics: Amines; Animals; Cells, Cultured; Chagas Disease; Leishmania donovani; Mice; Nitro Compounds; Parasitic Sensitivity Tests; Rats; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma brucei rhodesiense; Trypanosoma cruzi	2011
In vitro activity of N-benzenesulfonylbenzotriazole on Trypanosoma cruzi epimastigote and trypomastigote forms. Experimental parasitology, 2012, Volume: 131, Issue:1 Topics: Animals; Cell Line; Cell Survival; Chagas Disease; Erythrocytes; Humans; Inhibitory Concentration 50; Macrophages; Mice; Mice, Inbred BALB C; Nitroimidazoles; Sulfonamides; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2012
Pharmacological characterization, structural studies, and in vivo activities of anti-Chagas disease lead compounds derived from tipifarnib. Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:9 Topics: 14-alpha Demethylase Inhibitors; Administration, Oral; Alkyl and Aryl Transferases; Animals; Chagas Disease; Crystallography, X-Ray; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Administration Schedule; Female; Humans; Mice; Models, Molecular; Nitroimidazoles; Quinolones; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2012
Evaluation of benznidazole treatment combined with nifurtimox, posaconazole or AmBisome® in mice infected with Trypanosoma cruzi strains. International journal of antimicrobial agents, 2012, Volume: 40, Issue:6 Topics: Amphotericin B; Animals; Chagas Disease; Disease Models, Animal; DNA, Protozoan; Drug Therapy, Combination; Female; Mice; Mice, Inbred BALB C; Nifurtimox; Nitroimidazoles; Parasite Load; Parasitemia; Real-Time Polymerase Chain Reaction; Treatment Outcome; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2012
Efficacy of voriconazole in a murine model of acute Trypanosoma cruzi infection. The Journal of antimicrobial chemotherapy, 2013, Volume: 68, Issue:4 Topics: Animal Structures; Animals; Antiprotozoal Agents; Chagas Disease; Disease Models, Animal; Female; Histocytochemistry; Mice; Mice, Inbred BALB C; Parasitemia; Pyrimidines; Survival Analysis; Triazoles; Trypanosoma cruzi; Voriconazole	2013
Organocatalytic, enantioselective synthesis of VNI: a robust therapeutic development platform for Chagas, a neglected tropical disease. Organic letters, 2012, Dec-21, Volume: 14, Issue:24 Topics: Animals; Chagas Disease; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Imidazoles; Mice; Molecular Structure; Neglected Diseases; Oxadiazoles; Triazoles; Tropical Medicine; Trypanosoma cruzi	2012
In vitro and in vivo activities of ravuconazole on Trypanosoma cruzi, the causative agent of Chagas disease. International journal of antimicrobial agents, 2003, Volume: 21, Issue:1 Topics: Animals; Chagas Disease; Dose-Response Relationship, Drug; Drug Resistance; Female; Mice; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2003
Parasitological cure of acute and chronic experimental Chagas disease using the long-acting experimental triazole TAK-187. Activity against drug-resistant Trypanosoma cruzi strains. International journal of antimicrobial agents, 2003, Volume: 21, Issue:1 Topics: Acute Disease; Animals; Chagas Disease; Chronic Disease; Dose-Response Relationship, Drug; Drug Resistance; Female; Mice; Triazoles; Trypanocidal Agents	2003
Activity of the new triazole derivative albaconazole against Trypanosoma (Schizotrypanum) cruzi in dog hosts. Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:11 Topics: Animals; Chagas Disease; Dogs; Enzyme-Linked Immunosorbent Assay; Immunoglobulin G; Monocytes; Nifurtimox; Nitroimidazoles; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2004
Comparative efficacies of TAK-187, a long-lasting ergosterol biosynthesis inhibitor, and benznidazole in preventing cardiac damage in a murine model of Chagas' disease. Antimicrobial agents and chemotherapy, 2005, Volume: 49, Issue:4 Topics: Acute Disease; Animals; Chagas Cardiomyopathy; Chagas Disease; Disease Models, Animal; Ergosterol; Male; Mice; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2005
Amiodarone has intrinsic anti-Trypanosoma cruzi activity and acts synergistically with posaconazole. Journal of medicinal chemistry, 2006, Feb-09, Volume: 49, Issue:3 Topics: Acute Disease; Amiodarone; Animals; Calcium; Chagas Disease; Chlorocebus aethiops; Crystallography, X-Ray; Drug Synergism; Ergosterol; Intramolecular Transferases; Mice; Models, Molecular; Molecular Structure; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells	2006
The Anti-Trypanosoma cruzi activity of posaconazole in a murine model of acute Chagas' disease is less dependent on gamma interferon than that of benznidazole. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:4 Topics: Animals; Chagas Disease; Interferon-gamma; Interleukin-12; Mice; Mice, Inbred C57BL; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2007
Experimental chemotherapy with combinations of ergosterol biosynthesis inhibitors in murine models of Chagas' disease. Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:6 Topics: Animals; Antifungal Agents; Chagas Disease; Disease Models, Animal; Ergosterol; Female; Ketoconazole; Mice; Naphthalenes; Terbinafine; Triazoles; Trypanocidal Agents	1993
Cure of short- and long-term experimental Chagas' disease using D0870. Science (New York, N.Y.), 1996, Aug-16, Volume: 273, Issue:5277 Topics: Animals; Base Sequence; Chagas Disease; Drug Administration Schedule; Ketoconazole; Molecular Sequence Data; Nifurtimox; Sterols; Time Factors; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	1996
Antiproliferative effects and mechanism of action of SCH 56592 against Trypanosoma (Schizotrypanum) cruzi: in vitro and in vivo studies. Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:7 Topics: Animals; Antiparasitic Agents; Chagas Disease; Dose-Response Relationship, Drug; Female; Mice; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	1998
SCH 56592. Drugs in R&D, 1999, Volume: 1, Issue:2 Topics: Animals; Antifungal Agents; Candidiasis; Chagas Disease; Drugs, Investigational; Fungi; Humans; Mice; Mycoses; Parasitic Diseases; Triazoles	1999
Activities of the triazole derivative SCH 56592 (posaconazole) against drug-resistant strains of the protozoan parasite Trypanosoma (Schizotrypanum) cruzi in immunocompetent and immunosuppressed murine hosts. Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:1 Topics: Acute Disease; Animals; Chagas Disease; Chronic Disease; Drug Resistance; Female; Immunocompetence; Immunosuppression Therapy; Mice; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2000
In vivo activity of the bis-triazole D0870 against drug-susceptible and drug-resistant strains of the protozoan parasite Trypanosoma cruzi. The Journal of antimicrobial chemotherapy, 2000, Volume: 46, Issue:1 Topics: Animals; Chagas Disease; Drug Resistance; Female; Mice; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2000
Cure of experimental Chagas' disease by the bis-triazole DO870 incorporated into 'stealth' polyethyleneglycol-polylactide nanospheres. The Journal of antimicrobial chemotherapy, 2001, Volume: 47, Issue:1 Topics: Animals; Chagas Disease; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Female; Mice; Microspheres; Polyesters; Polyethylene Glycols; Treatment Outcome; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	2001
Novel heterocyclic nitrofurfural hydrazones. In vivo antirypanosomal activity. Journal of medicinal chemistry, 1976, Volume: 19, Issue:4 Topics: Animals; Chagas Disease; Hydrazones; Imidazoles; Male; Mice; Mice, Inbred C3H; Nitrofurans; Pyrazoles; Pyrimidines; Structure-Activity Relationship; Triazoles; Trypanocidal Agents	1976
Research for new antichagasic drugs. Chemical & pharmaceutical bulletin, 1991, Volume: 39, Issue:8 Topics: Animals; Azoles; Benzimidazoles; Chagas Disease; Imidazoles; Indazoles; Indoles; Mice; Nifurtimox; Nitro Compounds; Thiophenes; Triazoles; Trypanocidal Agents; Trypanosoma cruzi	1991