Compounds > triazoles
Page last updated: 2024-08-24

triazoles and cep 33779

triazoles has been researched along with cep 33779 in 11 studies

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's10 (90.91)24.3611
2020's1 (9.09)2.80

Authors

AuthorsStudies
Albom, MS; Angeles, TS; Ator, MA; Dobrzanski, P; Dorsey, BD; Dugan, BJ; Gingrich, DE; Lu, LD; Ruggeri, BA; Seavey, MM; Serdikoff, C; Stump, KL1
Albom, MS; Angeles, TS; Ator, MA; Dobrzanski, P; Dorsey, BD; Dugan, BJ; Gingrich, DE; Lu, LD; Mason, JL; Ruggeri, BA; Seavey, MM; Serdikoff, C; Stump, KL; Wallace, NH1
Dobrzanski, P; Hockeimer, W; Lu, LD; O'Kane, TM; Ruggeri, BA; Seavey, MM; Stump, KL; Wallace, NH1
Putterman, C; Tagoe, C1
Aimone, LD; Albom, MS; Angeles, TS; Ator, MA; Curry, MA; Dobrzanski, P; Dorsey, BD; Dugan, BJ; Gingrich, DE; Huang, Z; Jan, M; Mason, JL; Mesaros, EF; Meyer, SL; Milkiewicz, KL; Ruggeri, BA; Serdikoff, C; Wells-Knecht, KJ; Zulli, AL1
Chen, LK; Chen, WQ; Chen, ZS; Fu, LW; Huang, ZC; Talele, TT; Tang, SJ; To, KK; Wang, F; Wang, XK; Zhang, YK1
Li, R; Luo, H; Wu, C; Xu, M; Zhang, X1
Cheon, JH; Kim, HS; Kim, KS; Kim, M; Yadav, DK; Yoon, S1
Cheon, JH; Kim, HS; Kim, JY; Lee, BM; Yoon, S1
Boran, A; Chen, Y; Gallo, J; Goldfarb, J; Hu, Y; Iyengar, R; Jayaraman, G; Li, L; Mariottini, C; Tavassoly, I; Tolentino, RE; Zhao, S1
Chang, Y; Chen, J; Christiano, AM; Dai, Z1

Other Studies

11 other study(ies) available for triazoles and cep 33779

ArticleYear
A highly selective, orally active inhibitor of Janus kinase 2, CEP-33779, ablates disease in two mouse models of rheumatoid arthritis.
    Arthritis research & therapy, 2011, Apr-21, Volume: 13, Issue:2

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Blotting, Western; Disease Models, Animal; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Janus Kinase 2; Mice; Mice, Inbred DBA; Pyridines; Triazoles

2011
Depletion of autoreactive plasma cells and treatment of lupus nephritis in mice using CEP-33779, a novel, orally active, selective inhibitor of JAK2.
    Journal of immunology (Baltimore, Md. : 1950), 2011, Oct-01, Volume: 187, Issue:7

    Topics: Administration, Oral; Animals; Antibodies, Antinuclear; Autoimmunity; Cell Separation; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Janus Kinase 2; Lupus Nephritis; Mice; Mice, Inbred MRL lpr; Plasma Cells; Pyridines; Triazoles

2011
Therapeutic efficacy of CEP-33779, a novel selective JAK2 inhibitor, in a mouse model of colitis-induced colorectal cancer.
    Molecular cancer therapeutics, 2012, Volume: 11, Issue:4

    Topics: Animals; Cell Line, Tumor; Colitis; Colorectal Neoplasms; Disease Models, Animal; Female; Humans; Janus Kinase 2; Mice; Mice, Inbred BALB C; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Triazoles

2012
JAK2 inhibition in murine systemic lupus erythematosus.
    Immunotherapy, 2012, Volume: 4, Issue:4

    Topics: Animals; Disease Models, Animal; Humans; Interleukin-6; Janus Kinase 2; Kidney; Lupus Erythematosus, Systemic; Lupus Nephritis; Mice; Plasma Cells; Pyridines; Signal Transduction; Treatment Outcome; Triazoles

2012
A selective, orally bioavailable 1,2,4-triazolo[1,5-a]pyridine-based inhibitor of Janus kinase 2 for use in anticancer therapy: discovery of CEP-33779.
    Journal of medicinal chemistry, 2012, Jun-14, Volume: 55, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Biological Availability; Cell Line; Crystallography, X-Ray; Dogs; Humans; Janus Kinase 2; Mice; Mice, Nude; Microsomes, Liver; Models, Molecular; Molecular Structure; Pyridines; Rats; Structure-Activity Relationship; Triazoles; Xenograft Model Antitumor Assays

2012
CEP-33779 antagonizes ATP-binding cassette subfamily B member 1 mediated multidrug resistance by inhibiting its transport function.
    Biochemical pharmacology, 2014, Sep-15, Volume: 91, Issue:2

    Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Neoplasm; Heterografts; Humans; Mice; Mice, Nude; Molecular Structure; Neoplasms, Experimental; Pyridines; Real-Time Polymerase Chain Reaction; Rhodamine 123; Topotecan; Triazoles

2014
JAK2 inhibitor CEP-33779 prevents mouse oocyte maturation
    Bioscience reports, 2017, Aug-31, Volume: 37, Issue:4

    Topics: Animals; Female; Janus Kinase 2; Meiosis; Mice; Oocytes; Pyridines; Triazoles

2017
The JAK2 inhibitors CEP-33779 and NVP-BSK805 have high P-gp inhibitory activity and sensitize drug-resistant cancer cells to vincristine.
    Biochemical and biophysical research communications, 2017, 09-02, Volume: 490, Issue:4

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Janus Kinase 2; Protein Kinase Inhibitors; Pyridines; Quinoxalines; Structure-Activity Relationship; Triazoles; Tumor Cells, Cultured; Vincristine

2017
P-gp Inhibition by XL019, a JAK2 Inhibitor, Increases Apoptosis of Vincristine-treated Resistant KBV20C Cells with Increased p21 and pH2AX Expression.
    Anticancer research, 2017, Volume: 37, Issue:12

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Cell Line, Tumor; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; Drug Resistance, Neoplasm; Drug Synergism; G2 Phase Cell Cycle Checkpoints; Histones; Humans; Janus Kinase 2; Phosphorylation; Proline; Pyridines; Pyrimidines; Triazoles; Vincristine

2017
Genomic signatures defining responsiveness to allopurinol and combination therapy for lung cancer identified by systems therapeutics analyses.
    Molecular oncology, 2019, Volume: 13, Issue:8

    Topics: Allopurinol; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genomics; Humans; Janus Kinase 2; Lung Neoplasms; Mice, Nude; Phenotype; Protein Kinase Inhibitors; Pyridines; Systems Analysis; Triazoles; Xenograft Model Antitumor Assays

2019
Selective inhibition of JAK3 signaling is sufficient to reverse alopecia areata.
    JCI insight, 2021, 04-08, Volume: 6, Issue:7

    Topics: Administration, Topical; Alopecia Areata; Animals; Azetidines; CD8-Positive T-Lymphocytes; Cytokines; Isonicotinic Acids; Janus Kinase 1; Janus Kinase 2; Janus Kinase 3; Macrophages; Mice, Inbred C3H; Nitriles; NK Cell Lectin-Like Receptor Subfamily K; Piperidines; Protein Kinase Inhibitors; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Triazoles

2021