Page last updated: 2024-11-12

pateamine a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

pateamine A: a 19-membered macrolide; structure in first source; inhibits eukaryotic translation initiation [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

pateamine : A marine macrodiolide that is isolated from the sponge Mycale hentscheli and exhibits anticancer and antiviral properties [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID10053416
CHEMBL ID1221966
CHEBI ID134184
SCHEMBL ID16103926
MeSH IDM0380312

Synonyms (11)

Synonym
CHEMBL1221966
pateamine a
(3s,6z,8e,11s,15r,17s)-15-amino-3-[(1e,3e,5e)-7-(dimethylamino)-2,5-dimethylhepta-1,3,5-trien-1-yl]-9,11,17-trimethyl-4,12-dioxa-20-thia-21-azabicyclo[16.2.1]henicosa-1(21),6,8,18-tetraene-5,13-dione
CHEBI:134184
139220-18-1
(-)-pateamine
pateamine
C19917
SCHEMBL16103926
DTXSID801098385
(3s,6z,8e,11s,15r,17s)-15-amino-3-[(1e,3e,5e)-7-(dimethylamino)-2,5-dimethyl-1,3,5-heptatrien-1-yl]-9,11,17-trimethyl-4,12-dioxa-20-thia-21-azabicyclo[16.2.1]heneicosa-1(21),6,8,18-tetraene-5,13-dione

Research Excerpts

Overview

Pateamine A is a naturally occurring metabolite extracted from the marine sponge Mycale hentscheli. It interacts specifically with the translation initiation factor eIF4A leading to the disruption of the eif4F complex.

ExcerptReferenceRelevance
"Pateamine A (Pat A) is a natural marine product that interacts specifically with the translation initiation factor eIF4A leading to the disruption of the eIF4F complex. "( Differential action of pateamine A on translation of genomic and subgenomic mRNAs from Sindbis virus.
Carrasco, L; García-Moreno, M; González-Almela, E; Northcote, P; Pelletier, J; Sanz, MA, 2015
)
2.17
"Pateamine A is a naturally occurring metabolite extracted from the marine sponge Mycale hentscheli. "( Synthesis of a simplified triazole analogue of pateamine A.
Brown, SL; Cuyamendous, C; Field, JJ; Harvey, JE; Hemi Cumming, A; Miller, JH; Tao, X; Teesdale-Spittle, PH, 2016
)
2.13
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (4)

RoleDescription
marine metaboliteAny metabolite produced during a metabolic reaction in marine macro- and microorganisms.
antiviral agentA substance that destroys or inhibits replication of viruses.
antineoplastic agentA substance that inhibits or prevents the proliferation of neoplasms.
eukaryotic initiation factor 4F inhibitorAny compound that inihibits the mammalian protein, eukaryotic initiation factor 4F.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (5)

ClassDescription
1,3-thiazoles
tertiary amino compoundA compound formally derived from ammonia by replacing three hydrogen atoms by organyl groups.
primary amino compoundA compound formally derived from ammonia by replacing one hydrogen atom by an organyl group.
olefinic compoundAny organic molecular entity that contains at least one C=C bond.
macrodiolideA macropolylide which contains two ester linkages in one macrocyclic ring.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (8)

Assay IDTitleYearJournalArticle
AID501254Inhibition of elF4A-mediated renilla luciferase translational activity at 100 to 200 nM in presence of HCV IRES element2010Nature chemical biology, Mar, Volume: 6, Issue:3
Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin.
AID1073652Antiproliferative activity against human Jurkat T cells assessed as DNA synthesis level after 24 hrs by thymidine incorporation assay2014Bioorganic & medicinal chemistry, Jan-01, Volume: 22, Issue:1
Second-generation derivatives of the eukaryotic translation initiation inhibitor pateamine A targeting eIF4A as potential anticancer agents.
AID1073655Antiproliferative activity against human HeLa cells assessed as DNA synthesis level after 24 hrs by thymidine incorporation assay2014Bioorganic & medicinal chemistry, Jan-01, Volume: 22, Issue:1
Second-generation derivatives of the eukaryotic translation initiation inhibitor pateamine A targeting eIF4A as potential anticancer agents.
AID1073651Antiproliferative activity against BAEC assessed as DNA synthesis level after 24 hrs by thymidine incorporation assay2014Bioorganic & medicinal chemistry, Jan-01, Volume: 22, Issue:1
Second-generation derivatives of the eukaryotic translation initiation inhibitor pateamine A targeting eIF4A as potential anticancer agents.
AID501373Inhibition of elF4A-mediated renilla luciferase translational activity at 200 to 2000 nM in presence of HCV IRES element2010Nature chemical biology, Mar, Volume: 6, Issue:3
Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin.
AID1073653Antiproliferative activity against human HaCaT cells assessed as DNA synthesis level after 24 hrs by thymidine incorporation assay2014Bioorganic & medicinal chemistry, Jan-01, Volume: 22, Issue:1
Second-generation derivatives of the eukaryotic translation initiation inhibitor pateamine A targeting eIF4A as potential anticancer agents.
AID1073650Immunosuppressive activity in human Jurkat T cells assessed as inhibition of IL-2 transcription2014Bioorganic & medicinal chemistry, Jan-01, Volume: 22, Issue:1
Second-generation derivatives of the eukaryotic translation initiation inhibitor pateamine A targeting eIF4A as potential anticancer agents.
AID1073654Antiproliferative activity against human RKO cells assessed as DNA synthesis level after 24 hrs by thymidine incorporation assay2014Bioorganic & medicinal chemistry, Jan-01, Volume: 22, Issue:1
Second-generation derivatives of the eukaryotic translation initiation inhibitor pateamine A targeting eIF4A as potential anticancer agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (38)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's15 (39.47)29.6817
2010's19 (50.00)24.3611
2020's4 (10.53)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 25.48

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index25.48 (24.57)
Research Supply Index3.69 (2.92)
Research Growth Index5.83 (4.65)
Search Engine Demand Index26.67 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (25.48)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews7 (17.95%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other32 (82.05%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]