inosine dialdehyde profile

inosine dialdehyde: do not confuse synonym ''diglycolaldehyde'' with synonym of same name for oxydiacetaldehyde (C4H603); RN given refers to (R-(R*,R*))-isomer; structure [MeSH]

ID Source	ID
PubMed CID	135400916
CHEMBL ID	1998222
SCHEMBL ID	2557589
MeSH ID	M0050561

ID Source

PubMed CID

135400916

CHEMBL ID

1998222

SCHEMBL ID

2557589

MeSH ID

M0050561

Synonyms (28)

Synonym
nsc-118994
9h-purine-9-acetaldehyde,6-dihydro-6-oxo-, (r,r)-
23590-99-0
diglycolaldehyde, .alpha.-(hydroxymethyl)-.alpha.'-(6-hydroxy-9h-purin-9-yl)-
9h-purine-9-acetaldehyde,6-dihydro-6-oxo-, (r-(r,r))-
nsc118994
inox
nsc 118994
inosine dialdehyde
(r,r)-alpha-(1-formyl-2-hydroxyethoxy)-1,6-dihydro-6-oxo-9h-purine-9-acetaldehyde
alpha-(hydroxymethyl)-alpha'-(6-hydroxy-9h-purin-9-yl) diglycolaldehyde
9h-purine-9-acetaldehyde, alpha-(1-formyl-2-hydroxyethoxy)-1,6-dihydro-6-oxo-, (r,(r,r))-
diglycoaldehyde
9h-purine-9-acetaldehyde, alpha-(1-formyl-2-hydroxyethoxy)-1,6-dihydro-6-oxo-, (r,r)-
NCI60_000456
4613t5zy7g ,
unii-4613t5zy7g
CHEMBL1998222
SCHEMBL2557589
ribox
9h-purine-9-acetaldehyde, .alpha.-(1-formyl-2-hydroxyethoxy)-1,6-dihydro-6-oxo-, (r,r)-
9h-purine-9-acetaldehyde, .alpha.-((r)-1-formyl-2-hydroxyethoxy)-1,6-dihydro-6-oxo-, (.alpha.r)-
9h-purine-9-acetaldehyde, .alpha.-(1-formyl-2-hydroxyethoxy)-1,6-dihydro-6-oxo-, (r-(r,r))-
(2r)-3-hydroxy-2-[(1r)-2-oxo-1-(6-oxo-6,9-dihydro-1h-purin-9-yl)ethoxy]propanal
(r)-3-hydroxy-2-((r)-2-oxo-1-(6-oxo-1h-purin-9(6h)-yl)ethoxy)propanal
Q27258885
DTXSID901135037
(alphar)-alpha-[(r)-1-formyl-2-hydroxyethoxy]-1,6-dihydro-6-oxo-9h-purine-9-acetaldehyde

Synonym

nsc-118994

9h-purine-9-acetaldehyde,6-dihydro-6-oxo-, (r,r)-

23590-99-0

diglycolaldehyde, .alpha.-(hydroxymethyl)-.alpha.'-(6-hydroxy-9h-purin-9-yl)-

9h-purine-9-acetaldehyde,6-dihydro-6-oxo-, (r-(r*,r*))-

nsc118994

inox

nsc 118994

inosine dialdehyde

(r,r)-alpha-(1-formyl-2-hydroxyethoxy)-1,6-dihydro-6-oxo-9h-purine-9-acetaldehyde

alpha-(hydroxymethyl)-alpha'-(6-hydroxy-9h-purin-9-yl) diglycolaldehyde

9h-purine-9-acetaldehyde, alpha-(1-formyl-2-hydroxyethoxy)-1,6-dihydro-6-oxo-, (r,(r*,r*))-

diglycoaldehyde

9h-purine-9-acetaldehyde, alpha-(1-formyl-2-hydroxyethoxy)-1,6-dihydro-6-oxo-, (r,r)-

NCI60_000456

4613t5zy7g ,

unii-4613t5zy7g

CHEMBL1998222

SCHEMBL2557589

ribox

9h-purine-9-acetaldehyde, .alpha.-(1-formyl-2-hydroxyethoxy)-1,6-dihydro-6-oxo-, (r,r)-

9h-purine-9-acetaldehyde, .alpha.-((r)-1-formyl-2-hydroxyethoxy)-1,6-dihydro-6-oxo-, (.alpha.r)-

9h-purine-9-acetaldehyde, .alpha.-(1-formyl-2-hydroxyethoxy)-1,6-dihydro-6-oxo-, (r-(r*,r*))-

(2r)-3-hydroxy-2-[(1r)-2-oxo-1-(6-oxo-6,9-dihydro-1h-purin-9-yl)ethoxy]propanal

(r)-3-hydroxy-2-((r)-2-oxo-1-(6-oxo-1h-purin-9(6h)-yl)ethoxy)propanal

Q27258885

DTXSID901135037

(alphar)-alpha-[(r)-1-formyl-2-hydroxyethoxy]-1,6-dihydro-6-oxo-9h-purine-9-acetaldehyde

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	10 (76.92)	18.7374
1990's	1 (7.69)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (7.69)	24.3611
2020's	1 (7.69)	2.80

Timeframe

Studies, This Drug (%)

All Drugs %

pre-1990

10 (76.92)

18.7374

1990's

1 (7.69)

18.2507

2000's

0 (0.00)

29.6817

2010's

1 (7.69)

24.3611

2020's

1 (7.69)

2.80

Publication Type	This drug (%)	All Drugs (%)
Trials	2 (12.50%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	1 (6.25%)	0.25%
Other	13 (81.25%)	84.16%

Publication Type

This drug (%)

All Drugs (%)

Trials

2 (12.50%)

5.53%

Reviews

0 (0.00%)

6.00%

Case Studies

0 (0.00%)

4.05%

Observational

1 (6.25%)

0.25%

Other

13 (81.25%)

84.16%

Substance	Studies	Classes	Roles	First Year	Last Year	Average Age	Relationship Strength	Trials	pre-1990	1990's	2010's
pyridoxal phosphate	2	methylpyridines; monohydroxypyridine; pyridinecarbaldehyde; vitamin B6 phosphate	coenzyme; cofactor; EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite	1979	1982	43.5	low	0	2	0	0
hydroxyurea	2	one-carbon compound; ureas	antimetabolite; antimitotic; antineoplastic agent; DNA synthesis inhibitor; EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor; genotoxin; immunomodulator; radical scavenger; teratogenic agent	1981	1989	39.0	low	0	2	0	0
potassium chloride	1	inorganic chloride; inorganic potassium salt; potassium salt	fertilizer	1982	1982	42.0	low	0	1	0	0
uridine	1	uridines	drug metabolite; fundamental metabolite; human metabolite	1982	1982	42.0	low	0	1	0	0
edetic acid	1	ethylenediamine derivative; polyamino carboxylic acid; tetracarboxylic acid	anticoagulant; antidote; chelator; copper chelator; geroprotector	1981	1981	43.0	low	0	1	0	0
cytidine	1	cytidines	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite	1982	1982	42.0	low	0	1	0	0
tubercidin	1	antibiotic antifungal agent; N-glycosylpyrrolopyrimidine; ribonucleoside	antimetabolite; antineoplastic agent; bacterial metabolite	1997	1997	27.0	low	0	0	1	0
cytarabine	1	beta-D-arabinoside; monosaccharide derivative; pyrimidine nucleoside	antimetabolite; antineoplastic agent; antiviral agent; immunosuppressive agent	1989	1989	35.0	low	0	1	0	0
deoxycytidine	1	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite	1985	1985	39.0	low	0	1	0	0
deoxyuridine	1	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite	1985	1985	39.0	low	0	1	0	0
guanazole	1	aromatic amine; triazoles	antineoplastic agent; DNA synthesis inhibitor; EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor	1985	1985	39.0	low	0	1	0	0
2'-deoxyadenosine triphosphate	1	2'-deoxyadenosine 5'-phosphate; purine 2'-deoxyribonucleoside 5'-triphosphate	Escherichia coli metabolite; mouse metabolite	1981	1981	43.0	low	0	1	0	0
caracemide	1			1989	1989	35.0	low	0	1	0	0
adenosine	1	adenosines; purines D-ribonucleoside	analgesic; anti-arrhythmia drug; fundamental metabolite; human metabolite; vasodilator agent	1982	1982	42.0	low	0	1	0	0
thymidine 5'-triphosphate	1	pyrimidine 2'-deoxyribonucleoside 5'-triphosphate; thymidine phosphate	Escherichia coli metabolite; mouse metabolite	1981	1981	43.0	low	0	1	0	0
triazoles	1	1,2,3-triazole		1985	1985	39.0	low	0	1	0	0
2,3-dihydro-1h-imidazo(1,2-b)pyrazole	1			1981	1981	43.0	low	0	1	0	0
formycin	1	formycin	antineoplastic agent	1997	1997	27.0	low	0	0	1	0
aphidicolin	1	tetracyclic diterpenoid	antimicrobial agent; antimitotic; antineoplastic agent; antiviral drug; apoptosis inducer; Aspergillus metabolite; DNA synthesis inhibitor; EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor; fungal metabolite	1989	1989	35.0	low	0	1	0	0
4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone	3			1979	1985	42.3	medium	0	3	0	0
deoxyguanosine triphosphate	1	deoxyguanosine phosphate; guanyl deoxyribonucleotide; purine 2'-deoxyribonucleoside 5'-triphosphate	Arabidopsis thaliana metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; plant metabolite; Saccharomyces cerevisiae metabolite	1981	1981	43.0	low	0	1	0	0
inosine	13	inosines; purines D-ribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite	1964	2020	36.5	high	1	10	1	2
allopurinol	1	nucleobase analogue; organic heterobicyclic compound	antimetabolite; EC 1.17.3.2 (xanthine oxidase) inhibitor; gout suppressant; radical scavenger	1997	1997	27.0	low	0	0	1	0
allopurinol riboside	1	nucleoside analogue	metabolite	1997	1997	27.0	low	0	0	1	0
formycins	1			1997	1997	27.0	low	0	0	1	0

Substance

Studies

Classes

Roles

First Year

Last Year

Average Age

Relationship Strength

Trials

pre-1990

1990's

2000's

2010's

post-2020

pyridoxal phosphate

methylpyridines;
monohydroxypyridine;
pyridinecarbaldehyde;
vitamin B6 phosphate

coenzyme;
cofactor;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite

1979

1982

43.5

low

hydroxyurea

one-carbon compound;
ureas

antimetabolite;
antimitotic;
antineoplastic agent;
DNA synthesis inhibitor;
EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor;
genotoxin;
immunomodulator;
radical scavenger;
teratogenic agent

1981

1989

39.0

low

potassium chloride

inorganic chloride;
inorganic potassium salt;
potassium salt

fertilizer

1982

42.0

low

uridine

uridines

drug metabolite;
fundamental metabolite;
human metabolite

1982

42.0

low

edetic acid

ethylenediamine derivative;
polyamino carboxylic acid;
tetracarboxylic acid

anticoagulant;
antidote;
chelator;
copper chelator;
geroprotector

1981

43.0

low

cytidine

cytidines

Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite

1982

42.0

low

tubercidin

antibiotic antifungal agent;
N-glycosylpyrrolopyrimidine;
ribonucleoside

antimetabolite;
antineoplastic agent;
bacterial metabolite

1997

27.0

low

cytarabine

beta-D-arabinoside;
monosaccharide derivative;
pyrimidine nucleoside

antimetabolite;
antineoplastic agent;
antiviral agent;
immunosuppressive agent

1989

35.0

low

deoxycytidine

pyrimidine 2'-deoxyribonucleoside

Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite

1985

39.0

low

deoxyuridine

pyrimidine 2'-deoxyribonucleoside

Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite

1985

39.0

low

guanazole

aromatic amine;
triazoles

antineoplastic agent;
DNA synthesis inhibitor;
EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor

1985

39.0

low

2'-deoxyadenosine triphosphate

2'-deoxyadenosine 5'-phosphate;
purine 2'-deoxyribonucleoside 5'-triphosphate

Escherichia coli metabolite;
mouse metabolite

1981

43.0

low

caracemide

1989

35.0

low

adenosine

adenosines;
purines D-ribonucleoside

analgesic;
anti-arrhythmia drug;
fundamental metabolite;
human metabolite;
vasodilator agent

1982

42.0

low

thymidine 5'-triphosphate

pyrimidine 2'-deoxyribonucleoside 5'-triphosphate;
thymidine phosphate

Escherichia coli metabolite;
mouse metabolite

1981

43.0

low

triazoles

1,2,3-triazole

1985

39.0

low

2,3-dihydro-1h-imidazo(1,2-b)pyrazole

1981

43.0

low

formycin

antineoplastic agent

1997

27.0

low

aphidicolin

tetracyclic diterpenoid

antimicrobial agent;
antimitotic;
antineoplastic agent;
antiviral drug;
apoptosis inducer;
Aspergillus metabolite;
DNA synthesis inhibitor;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
fungal metabolite

1989

35.0

low

4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone

1979

1985

42.3

medium

deoxyguanosine triphosphate

deoxyguanosine phosphate;
guanyl deoxyribonucleotide;
purine 2'-deoxyribonucleoside 5'-triphosphate

Arabidopsis thaliana metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite

1981

43.0

low

inosine

inosines;
purines D-ribonucleoside

Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite

1964

2020

36.5

high

allopurinol

nucleobase analogue;
organic heterobicyclic compound

antimetabolite;
EC 1.17.3.2 (xanthine oxidase) inhibitor;
gout suppressant;
radical scavenger

1997

27.0

low

allopurinol riboside

nucleoside analogue

metabolite

1997

27.0

low

formycins

1997

27.0

low

Condition	Studies	First Year	Last Year	Average Age	Relationship Strength	Trials	pre-1990	2010's
Anemia	1	2020	2020	4.0	low	1	0	1
Benign Neoplasms	1	1981	1981	43.0	low	0	1	0
Blood Diseases	1	1981	1981	43.0	low	0	1	0
Cancer of Liver	1	1977	1977	47.0	low	0	1	0
Carcinoma, Ehrlich Tumor	2	1979	1981	44.0	low	0	2	0
Carcinoma, Hepatocellular	1	1977	1977	47.0	low	0	1	0
Critical Illness	1	2020	2020	4.0	low	1	0	1
Experimental Leukemia	1	1989	1989	35.0	low	0	1	0
Experimental Neoplasms	2	1977	1982	44.5	low	0	2	0
Hematologic Diseases	1	1981	1981	43.0	low	0	1	0
Hepatocellular Carcinoma	1	1977	1977	47.0	low	0	1	0
Leucocythaemia	1	1981	1981	43.0	low	0	1	0
Leukemia	1	1981	1981	43.0	low	0	1	0
Leukemia L 1210	1	1985	1985	39.0	low	0	1	0
Leukemia P388	1	1989	1989	35.0	low	0	1	0
Liver Neoplasms	1	1977	1977	47.0	low	0	1	0
Malignant Melanoma	1	1982	1982	42.0	low	0	1	0
Melanoma	1	1982	1982	42.0	low	0	1	0
Neoplasms	1	1981	1981	43.0	low	0	1	0

Condition

Indicated

Studies

First Year

Last Year

Average Age

Relationship Strength

Trials

pre-1990

1990's

2000's

2010's