Compounds > 1-adamantanol
Page last updated: 2024-11-06

1-adamantanol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID64152
CHEMBL ID2041310
SCHEMBL ID148421
SCHEMBL ID14473233
SCHEMBL ID23333268
MeSH IDM0397925

Synonyms (60)

Synonym
HMS1758O22
AC-16092
nsc 108837
nsc 91633
ai3-61285
tricyclo(3.3.1.13,7)decan-1-ol
tricyclo(3.3.1.1(sup 3,7))decan-1-ol
einecs 212-202-8
tricyclo[3.3.1.1(3,7)]decan-1-ol
SDCCGMLS-0066229.P001
nsc-91633
nsc91633
nsc-108837
1-hydroxyadamantane
1-adamantanol ,
768-95-6
tricyclo[3.3.1.13,7]decan-1-ol
1-adamantol
nsc108837
inchi=1/c10h16o/c11-10-4-7-1-8(5-10)3-9(2-7)6-10/h7-9,11h,1-6h
tricyclo[3.3.1.1~3,7~]decan-1-ol
adamantan-1-ol
1-adamantanol, reagentplus(r), 99%
STK387538
A0939
AKOS000264926
1-(1-adamantyl)-3-(dimethylamino)propan-1-ol hydrochloride
A838888
AKOS004908005
CHEMBL2041310
p9j0b0c8zb ,
unii-p9j0b0c8zb
FT-0607301
PS-4604
AKOS015904444
BBL033940
hydroxyadamantane
adamantane-1-ol
1 -adamantanol
1-admantanol
adamantyl alcohol
SCHEMBL148421
DTXSID10227620
SCHEMBL14473233
VLLNJDMHDJRNFK-CHIWXEEVSA-N
adamantol-(1)
1-adamantyl alcohol
tricyclo(3.3.1.1(3,7))-n-decanol
W-104337
STR07597
CS-W020580
mfcd00074729
1-adamantanol, purum, >=99.0% (gc)
1-adamantanol, vetec(tm) reagent grade, 98%
SY010553
Z56771134
F0701-0170
AMY25777
SCHEMBL23333268
EN300-16775
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (15)

Assay IDTitleYearJournalArticle
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID668904Inhibition of Influenza A Virus M2 proton channel expressed in Xenopus laevis oocytes after 2 mins by two-electrode patch clamp assay2011ACS medicinal chemistry letters, Apr-14, Volume: 2, Issue:4
Exploring the Requirements for the Hydrophobic Scaffold and Polar Amine in inhibitors of M2 from Influenza A Virus.
AID1661728Binding affinity to HSA assessed as free fraction by HPLC analysis2020ACS medicinal chemistry letters, Aug-13, Volume: 11, Issue:8
Systematic Investigation of the Permeability of Androgen Receptor PROTACs.
AID668906Inhibition of Influenza A Virus M2 proton channel S31N mutant expressed in Xenopus laevis oocytes at 100 uM after 2 mins by two-electrode patch clamp assay2011ACS medicinal chemistry letters, Apr-14, Volume: 2, Issue:4
Exploring the Requirements for the Hydrophobic Scaffold and Polar Amine in inhibitors of M2 from Influenza A Virus.
AID1123154Hypobetalipoproteinemic activity in diet-induced hypercholesteremic rat model assessed as decrease in total serum cholesterol at 50 mg/kg, po relative to control1979Journal of medicinal chemistry, Jan, Volume: 22, Issue:1
Hypobetalipoproteinemic agents. 2. Compounds related to 4-(1-adamantyloxy)aniline.
AID668905Inhibition of Influenza A Virus M2 proton channel V27A mutant expressed in Xenopus laevis oocytes at 100 uM after 2 mins by two-electrode patch clamp assay2011ACS medicinal chemistry letters, Apr-14, Volume: 2, Issue:4
Exploring the Requirements for the Hydrophobic Scaffold and Polar Amine in inhibitors of M2 from Influenza A Virus.
AID1123155Hypobetalipoproteinemic activity in diet-induced hypercholesteremic rat model assessed as decrease in heparin precipitating lipoproteins at 50 mg/kg, po relative to control1979Journal of medicinal chemistry, Jan, Volume: 22, Issue:1
Hypobetalipoproteinemic agents. 2. Compounds related to 4-(1-adamantyloxy)aniline.
AID1123157Toxicity in diet-induced hypercholesteremic rat model assessed as increase in body weight at 50 mg/kg, po relative to control1979Journal of medicinal chemistry, Jan, Volume: 22, Issue:1
Hypobetalipoproteinemic agents. 2. Compounds related to 4-(1-adamantyloxy)aniline.
AID1661729Chromatographic hydrophobicity index, log D of the compound at pH 7.4 by HPLC analysis2020ACS medicinal chemistry letters, Aug-13, Volume: 11, Issue:8
Systematic Investigation of the Permeability of Androgen Receptor PROTACs.
AID668903Inhibition of Influenza A Virus M2 proton channel expressed in Xenopus laevis oocytes at 100 uM after 2 mins by two-electrode patch clamp assay2011ACS medicinal chemistry letters, Apr-14, Volume: 2, Issue:4
Exploring the Requirements for the Hydrophobic Scaffold and Polar Amine in inhibitors of M2 from Influenza A Virus.
AID1123158Toxicity in diet-induced hypercholesteremic rat model assessed as increase in food intake at 50 mg/kg, po relative to control1979Journal of medicinal chemistry, Jan, Volume: 22, Issue:1
Hypobetalipoproteinemic agents. 2. Compounds related to 4-(1-adamantyloxy)aniline.
AID1123156Selectivity ratio of T/C for heparin precipitating lipoproteins to T/C for total serum cholesterol in diet-induced hypercholesteremic rat model1979Journal of medicinal chemistry, Jan, Volume: 22, Issue:1
Hypobetalipoproteinemic agents. 2. Compounds related to 4-(1-adamantyloxy)aniline.
AID1661727Apparent permeability in pH 7.4 ammonium acetate buffer incubated for 5 hrs by PAMPA2020ACS medicinal chemistry letters, Aug-13, Volume: 11, Issue:8
Systematic Investigation of the Permeability of Androgen Receptor PROTACs.
AID1661730Protac activity at VHL/androgen receptor in human LNCaP cells assessed as induction of androgen receptor protein degradation at 1 uM incubated for 6 hrs by Western blot analysis relative to control2020ACS medicinal chemistry letters, Aug-13, Volume: 11, Issue:8
Systematic Investigation of the Permeability of Androgen Receptor PROTACs.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (9.09)18.7374
1990's0 (0.00)18.2507
2000's3 (27.27)29.6817
2010's5 (45.45)24.3611
2020's2 (18.18)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 42.84

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index42.84 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index56.52 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (42.84)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
4-aminophenol
4-aminophenol: RN given refers to parent cpd. 4-aminophenol : An amino phenol (one of the three possible isomers) which has the single amino substituent located para to the phenolic -OH group.		1.9510aminophenolallergen;
metabolite
dimethyl sulfoxide
Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.. dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.		210sulfoxide;
volatile organic compound		alkylating agent;
antidote;
Escherichia coli metabolite;
geroprotector;
MRI contrast agent;
non-narcotic analgesic;
polar aprotic solvent;
radical scavenger
uracil
2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder		2.0110pyrimidine nucleobase;
pyrimidone		allergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
prodrug;
Saccharomyces cerevisiae metabolite
1-aminobenzotriazole
[no description available]		2.0310
vitamin k 3
Vitamin K 3: A synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.		2.03101,4-naphthoquinones;
vitamin K		angiogenesis inhibitor;
antineoplastic agent;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
human urinary metabolite;
nutraceutical
thymidine
[no description available]		2.0110pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
metabolite;
mouse metabolite
cyclohexanol
Cyclohexanols: Monohydroxy derivatives of cyclohexanes that contain the general formula R-C6H11O. They have a camphorlike odor and are used in making soaps, insecticides, germicides, dry cleaning, and plasticizers.. cyclohexanols : An alcohol in which one or more hydroxy groups are attached to a cyclohexane skeleton.		210cyclohexanols;
secondary alcohol		solvent
adamantane
Adamantane: A tricyclo bridged hydrocarbon.		8.360adamantanes;
polycyclic alkane
thiazoles
[no description available]		2.25101,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
pyrazines
Pyrazines: A heterocyclic aromatic organic compound with the chemical formula C4H4N2.. pyrazine : A diazine that is benzene in which the carbon atoms at positions 1 and 4 have been replaced by nitrogen atoms.		2.0710diazine;
pyrazines		Daphnia magna metabolite
deoxyuridine
[no description available]		2.0110pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
[2-(2,6-dimethylanilino)-2-oxoethyl]-diethyl-(phenylmethyl)ammonium
denatonium: a potent bittering agent		2.2510amino acid amide
1-adamantanecarboxamide
[no description available]		2.0610
zidovudine
Zidovudine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.. zidovudine : A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase.		2.0110azide;
pyrimidine 2',3'-dideoxyribonucleoside		antimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor
2-adamantanol
[no description available]		2.0310
amantadine hydrochloride
[no description available]		2.0610hydrochlorideantiviral agent;
dopamine agonist;
NMDA receptor antagonist
adamantanone
adamantanone: structure		2.0610adamantanones
triazoles
Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.		2.03101,2,3-triazole
alagebrium
alagebrium: an advanced glycation endproducts (AGE) cross-link breaker		2.2510
betadex
beta-Cyclodextrins: Cyclic GLUCANS consisting of seven (7) glucopyranose units linked by 1,4-glycosidic bonds.		210cyclodextrin
isoborneol
isoborneol: RN given refers to cpd without isomeric designation; structure		210borneol
ConditionIndicatedRelationship StrengthStudiesTrials
Elevated Cholesterol
[description not available]		01.9510
Hypercholesterolemia
A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.		01.9510
Encephalitis, Polio
[description not available]		02.0610
Poliomyelitis
An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)		02.0610