Compounds > triazoles
Page last updated: 2024-08-24

triazoles and pyrimidine

triazoles has been researched along with pyrimidine in 44 studies

Research

Studies (44)

TimeframeStudies, this research(%)All Research%
pre-19902 (4.55)18.7374
1990's0 (0.00)18.2507
2000's4 (9.09)29.6817
2010's26 (59.09)24.3611
2020's12 (27.27)2.80

Authors

AuthorsStudies
Fotsch, C; St Jean, DJ1
Entrala, E; Fernandez-Ramos, C; Luque, F; Navarro, J; Rosales, MJ; Salas, MC; Sánchez-Moreno, M1
Baraldi, PG; Borean, PA; Cacciari, B; Da Ros, T; Fruttarolo, F; Pastorin, G; Spalluto, G; Tabrizi, MA; Varanin, K1
MAKISUMI, Y1
MAKISUMI, Y; TORI, K; WATANABE, H1
Intine, RV; Maraia, RJ; Schwartz, EI1
Borea, PA; Catarzi, D; Colotta, V; Filacchioni, G; Lenzi, O; Morizzo, E; Moro, S; Paoletta, S; Poli, D; Varani, K; Varano, F; Vincenzi, F1
Elchinger, PH; Faugeras, PA; Lucas, R; Zerrouki, R1
Deflorian, F; Gao, ZG; Jacobson, KA; Kumar, TS; Shinkre, BA; Trenkle, WC1
Andersen, NK; Døssing, H; Jensen, F; Nielsen, P; Vester, B1
Huang, LH; Lai, YW; Liu, HM; Lu, YZ; Song, CJ; Wang, YG; Xie, ZY; Zheng, YF1
Aghazadeh Tabrizi, M; Baraldi, PG; Baraldi, S; Borea, PA; Moorman, AR; Preti, D; Romagnoli, R; Saponaro, G; Varani, K1
Fandzloch, M; Popławska, B; Sitkowski, J; Łakomska, I1
Gupta, M; Kaur, P; Kumar, M; Sharma, M; Singh, D1
Atwal, K; Blanar, M; Caringal, Y; Conder, ML; Finlay, HJ; Harper, T; Hsueh, MM; Jiang, J; Kover, A; Levesque, P; Lloyd, J; Wexler, R; Xing, D1
Kumar, N; Kumari, N; Luthra, PM; Mishra, CB; Mongre, R; Prakash, A1
Espinoza-Vázquez, A; González-Olvera, R; Negrón-Silva, GE; Palomar-Pardavé, ME; Romero-Romo, MA; Santillan, R1
Dong, Q; Fan, J; Feng, J; Gong, A; Liu, Z; Luan, T; Qu, J; Sun, P; Tu, W; Xu, G; Yang, F; Yuan, J; Zhang, H; Zhang, L1
Kimura, I; Nishigori, K; Ono, M; Onoe, S; Saji, H; Sampei, S; Temma, T1
Ganesh Kumar, C; Malla Reddy, G; Nagender, P; Naresh Kumar, R; Narsaiah, B; Poornachandra, Y1
Pathak, AK; Pathak, V; Reynolds, RC1
Abbas, SE; Abdel-Aziz, HA; Abou-Seri, SM; Eladwy, RA; Fares, M; Youssef, MM1
Nagesh, N; Raju, G; Reddy, ChR; Reddy, MD; Srinivas, R1
Hu, B; Liu, HM; Liu, Y; Ma, LY; Pang, LP; Shao, KP; Wang, B; Xue, DQ; Zhang, BL; Zhang, E; Zhang, M1
David, L; Elster, L; Jensen, T; Klewe, IV; Loechel, F; Nielsen, SM; Poda, SB; Volbracht, C; Watson, SP1
Appalanaidu, K; Bhadra, MP; Dadmal, TL; Kishore, KS; Kumbhare, RM; Pushpa Valli, SN; Ramaiah, MJ; Rao, YK; Tiwari, SK1
De Clercq, E; Fang, Z; Huang, B; Kang, D; Liu, H; Liu, X; Pannecouque, C; Zhan, P; Zhang, L1
Liu, HM; Ma, LY; Pang, LP; Shao, KP; Wang, B; Wang, SQ; Xue, DQ; Zhang, M; Zheng, YC1
Baumann, M; Baxendale, IR; Rodriguez Garcia, AM1
Chaudhary, AS; Chen, W; Cui, J; Dai, C; Damera, K; Hsieh, YH; Jin, J; Tai, PC; Wang, B; Zhang, H1
Ahmad, F; Hassan, MI; Idrees, D; Kumari, S; Mishra, CB; Prakash, A; Tiwari, M1
Chen, ZS; Guo, Q; Liu, GY; Liu, HM; Liu, Y; Ma, LY; Pang, LP; Wang, B; Zhang, XH; Zhang, XY; Zhao, B; Zhao, YD1
Chen, XG; Guo, SX; He, SJ; Li, L; Liu, SW; Nandakumar, KS; Tang, XD; Wan, YH; Wu, WY; Wu, XY; Yao, XG; Zou, M1
Chen, XH; Li, ZH; Liu, GZ; Ma, JL; Qin, TT; Ren, WH; Zhang, XH; Zhang, ZQ; Zhao, TQ1
Fandzloch, M; Gubernator, J; Jaromin, A; Lewińska, A; Sitkowski, J; Wiśniewska, J; Wojtczak, A; Zaremba-Czogalla, M; Łakomska, I1
Liu, HM; Ma, XB; Wang, S; Xu, YC; Yu, B; Yuan, XH1
Hewlett, K; Hughes, SH; Pauly, GT; Schneider, JP; Smith, SJ1
Bissaro, M; Bortolozzi, R; Cozza, G; Federico, S; Grieco, I; Mariotto, E; Martinez, A; Moro, S; Perez, C; Perez, DI; Redenti, S; Spalluto, G; Tiz, DB; Viola, G1
Hoda, N; Manzoor, S; Petreni, A; Raza, MK; Supuran, CT1
Duan, Y; Wang, Y1
Abd El-Mageed, MMA; Eissa, AAM; Farag, AE; Osman, EEA1
Jakubowski, M; Jarzęcki, AA; Kaszuba, A; Sitkowski, J; Wojtczak, A; Łakomska, I1
Anh, HH; Giang, NTK; Hai, DS; Hanh, NT; Huyen, LT; Thanh, ND; Toan, VN; Van, HTK1
Algieri, V; Costanzo, P; De Nino, A; Fiorani, G; Jiménez-Osés, G; Jiritano, A; Maiuolo, L; Olivito, F; Peccati, F; Tallarida, MA1

Reviews

2 review(s) available for triazoles and pyrimidine

ArticleYear
Mitigating heterocycle metabolism in drug discovery.
    Journal of medicinal chemistry, 2012, Jul-12, Volume: 55, Issue:13

    Topics: Animals; Biotransformation; Databases, Factual; Drug Discovery; Drug Interactions; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Pharmaceutical Preparations; Rats

2012
Pyrazolo-triazolo-pyrimidine derivatives as adenosine receptor antagonists: a possible template for adenosine receptor subtypes?
    Current pharmaceutical design, 2002, Volume: 8, Issue:26

    Topics: Animals; Humans; Purinergic P1 Receptor Antagonists; Pyrazoles; Pyrimidines; Receptors, Purinergic P1; Triazoles

2002

Other Studies

42 other study(ies) available for triazoles and pyrimidine

ArticleYear
Biochemical and ultrastructural alterations caused by newly synthesized 1,2,4-triazole[1,5a]pyrimidine derivatives against Phytomonas staheli (Trypanosomatidae).
    Toxicology in vitro : an international journal published in association with BIBRA, 2000, Volume: 14, Issue:6

    Topics: Animals; Antiparasitic Agents; DNA; In Vitro Techniques; Magnetic Resonance Spectroscopy; Models, Biological; Organelles; Protein Biosynthesis; Proteins; Pyrimidines; RNA; Triazoles; Trypanosomatina

2000
STUDIES ON AZAINDOLIZINE COMPOUNDS. XV. THE ALLYL REARRANGEMENT OF 5-METHYL-7-ALLYLOXY-S-TRIAZOLO(1,5-A)PYRIMIDINE.
    Chemical & pharmaceutical bulletin, 1963, Volume: 11

    Topics: Chemistry, Pharmaceutical; Pyrimidines; Research; Triazoles

1963
STUDIES ON AZAINDOLIZINE COMPOUNDS. XVIII. PROTON MAGNETIC RESONANCE SPECTRA OF S-TRIAZOLO-(1,5-A)PYRIMIDINE AND ITS DERIVATIVES.
    Chemical & pharmaceutical bulletin, 1964, Volume: 12

    Topics: Chemistry, Pharmaceutical; Magnetic Resonance Spectroscopy; Protons; Pyrimidines; Research; Spectrum Analysis; Triazoles

1964
CK2 is responsible for phosphorylation of human La protein serine-366 and can modulate rpL37 5'-terminal oligopyrimidine mRNA metabolism.
    Molecular and cellular biology, 2004, Volume: 24, Issue:21

    Topics: Alanine; Apoptosis; Autoantigens; Casein Kinase II; Cell Line; Humans; Mutation; Phosphorylation; Phosphoserine; Polyribosomes; Protein Processing, Post-Translational; Pyrimidines; Ribonucleoproteins; Ribosomal Proteins; RNA, Messenger; Serine; SS-B Antigen; Triazoles

2004
2-Phenylpyrazolo[4,3-d]pyrimidin-7-one as a new scaffold to obtain potent and selective human A3 adenosine receptor antagonists: new insights into the receptor-antagonist recognition.
    Journal of medicinal chemistry, 2009, Dec-10, Volume: 52, Issue:23

    Topics: Adenosine A2 Receptor Antagonists; Adenosine A3 Receptor Antagonists; Amino Acid Sequence; Animals; CHO Cells; Cricetinae; Cricetulus; Humans; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Protein Binding; Pyrazoles; Pyrimidines; Pyrimidinones; Receptor, Adenosine A2A; Receptor, Adenosine A3; Substrate Specificity; Triazines; Triazoles

2009
Pyrimidine-purine and pyrimidine heterodinucleosides synthesis containing a triazole linkage.
    Nucleosides, nucleotides & nucleic acids, 2010, Volume: 29, Issue:3

    Topics: Catalysis; Copper; Cyclization; Nucleic Acid Conformation; Oligonucleotides; Purines; Pyrimidines; Triazoles

2010
Synthesis and evaluation of 1,2,4-triazolo[1,5-c]pyrimidine derivatives as A2A receptor-selective antagonists.
    Bioorganic & medicinal chemistry letters, 2010, Oct-01, Volume: 20, Issue:19

    Topics: Adenosine A2 Receptor Antagonists; Binding Sites; Cell Line; Computer Simulation; Contrast Media; Fluorine Radioisotopes; Humans; Positron-Emission Tomography; Protein Structure, Tertiary; Pyrazoles; Pyrimidines; Receptor, Adenosine A2A; Triazoles

2010
Duplex and triplex formation of mixed pyrimidine oligonucleotides with stacking of phenyl-triazole moieties in the major groove.
    The Journal of organic chemistry, 2011, Aug-05, Volume: 76, Issue:15

    Topics: Base Sequence; Circular Dichroism; Deoxycytidine; Deoxyuridine; DNA, Complementary; Models, Molecular; Molecular Structure; Nucleic Acid Conformation; Nucleosides; Nucleotides; Oligonucleotides; Pyrimidines; RNA, Complementary; Triazoles

2011
Synthesis of novel D-ring fused 7'-aryl-androstano[17,16-d][1,2,4] triazolo[1,5-a]pyrimidines.
    Steroids, 2012, Volume: 77, Issue:5

    Topics: Aldehydes; Androstanols; Dehydroepiandrosterone; Heterocyclic Compounds; Models, Chemical; Molecular Structure; Pyrimidines; Steroids; Triazoles

2012
Pyrrolo- and pyrazolo-[3,4-e][1,2,4]triazolo[1,5-c]pyrimidines as adenosine receptor antagonists.
    Bioorganic & medicinal chemistry, 2012, Jan-15, Volume: 20, Issue:2

    Topics: Humans; Protein Binding; Purinergic P1 Receptor Antagonists; Pyrazoles; Pyrimidines; Receptor, Adenosine A2A; Receptor, Adenosine A3; Structure-Activity Relationship; Triazoles

2012
Platinum(II) complexes with 5,7-disubstituted-1,2,4-triazolo [1,5-a]pyrimidines: spectroscopical characterization and cytotoxic activity in vitro.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2012, Volume: 91

    Topics: Antineoplastic Agents; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Female; Humans; Magnetic Resonance Spectroscopy; Organoplatinum Compounds; Pyrimidines; Triazoles

2012
Synthesis, evaluation and molecular docking of thiazolopyrimidine derivatives as dipeptidyl peptidase IV inhibitors.
    Chemical biology & drug design, 2012, Volume: 80, Issue:6

    Topics: Animals; Binding Sites; Diabetes Mellitus, Experimental; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Hypoglycemic Agents; Male; Molecular Docking Simulation; Protein Structure, Tertiary; Pyrimidines; Rats; Rats, Wistar; Structure-Activity Relationship; Triazoles

2012
Triazolo and imidazo dihydropyrazolopyrimidine potassium channel antagonists.
    Bioorganic & medicinal chemistry letters, 2013, Mar-15, Volume: 23, Issue:6

    Topics: Animals; Cell Line; Imidazoles; Isomerism; Kv1.5 Potassium Channel; Mice; Potassium Channel Blockers; Potassium Channels; Protein Binding; Pyrazoles; Pyrimidines; Structure-Activity Relationship; Triazoles

2013
8-(Furan-2-yl)-3-phenethylthiazolo[5,4-e][1,2,4]triazolo[1,5-c]pyrimidine-2(3H)-thione as novel, selective and potent adenosine A(2A) receptor antagonist.
    Neuroscience letters, 2014, Jan-13, Volume: 558

    Topics: Adenosine A2 Receptor Antagonists; Animals; Catalepsy; Cyclic AMP; HEK293 Cells; Heterocyclic Compounds, 3-Ring; Humans; Male; Mice; Molecular Docking Simulation; Motor Activity; Pyrimidines; Radioligand Assay; Receptor, Adenosine A2A; Rotarod Performance Test; Triazoles

2014
Multicomponent click synthesis of new 1,2,3-triazole derivatives of pyrimidine nucleobases: promising acidic corrosion inhibitors for steel.
    Molecules (Basel, Switzerland), 2013, Dec-06, Volume: 18, Issue:12

    Topics: Click Chemistry; Corrosion; Electric Impedance; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Pyrimidines; Steel; Triazoles

2013
Synthesis and biological evaluation of cyclopentyl-triazolol-pyrimidine (CPTP) based P2Y12 antagonists.
    Bioorganic & medicinal chemistry letters, 2014, Jan-01, Volume: 24, Issue:1

    Topics: Administration, Oral; Animals; Cyclopentanes; Dogs; Dose-Response Relationship, Drug; Humans; Molecular Structure; Platelet Aggregation; Platelet-Rich Plasma; Purinergic P2Y Receptor Antagonists; Pyrimidines; Rats; Receptors, Purinergic P2Y12; Structure-Activity Relationship; Triazoles

2014
Development of a radioiodinated triazolopyrimidine probe for nuclear medical imaging of fatty acid binding protein 4.
    PloS one, 2014, Volume: 9, Issue:4

    Topics: Adipose Tissue; Animals; Autoradiography; Carboxylic Acids; Cell Line; Cell Line, Tumor; Fatty Acid-Binding Proteins; Immunohistochemistry; Iodine Radioisotopes; Male; Mice; Mice, Inbred BALB C; Protein Binding; Pyrimidines; Pyrimidinones; Rats; Rats, Sprague-Dawley; Tissue Distribution; Triazoles

2014
Synthesis, cytotoxicity, antimicrobial and anti-biofilm activities of novel pyrazolo[3,4-b]pyridine and pyrimidine functionalized 1,2,3-triazole derivatives.
    Bioorganic & medicinal chemistry letters, 2014, Jul-01, Volume: 24, Issue:13

    Topics: Anti-Bacterial Agents; Antineoplastic Agents; Bacteria; Biofilms; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HeLa Cells; Humans; MCF-7 Cells; Microbial Sensitivity Tests; Molecular Structure; Pyrazoles; Pyridines; Pyrimidines; Structure-Activity Relationship; Triazoles

2014
Solution-phase parallel synthesis of acyclic nucleoside libraries of purine, pyrimidine, and triazole acetamides.
    ACS combinatorial science, 2014, Sep-08, Volume: 16, Issue:9

    Topics: Acetamides; Molecular Structure; Nucleosides; Purines; Pyrimidines; Small Molecule Libraries; Solutions; Triazoles

2014
Synthesis and antitumor activity of pyrido [2,3-d]pyrimidine and pyrido[2,3-d] [1,2,4]triazolo[4,3-a]pyrimidine derivatives that induce apoptosis through G1 cell-cycle arrest.
    European journal of medicinal chemistry, 2014, Aug-18, Volume: 83

    Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Cell Line, Tumor; Chemistry Techniques, Synthetic; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; Pyrimidines; Triazoles

2014
Studies on non-covalent interaction of coumarin attached pyrimidine and 1-methyl indole 1,2,3 triazole analogues with intermolecular telomeric G-quadruplex DNA using ESI-MS and spectroscopy.
    Nucleosides, nucleotides & nucleic acids, 2014, Volume: 33, Issue:7

    Topics: Coumarins; DNA; G-Quadruplexes; Humans; Indoles; Pyrimidines; Spectrometry, Mass, Electrospray Ionization; Spectrum Analysis; Telomere; Triazoles

2014
Design and synthesis of novel 1,2,3-triazole-pyrimidine hybrids as potential anticancer agents.
    European journal of medicinal chemistry, 2014, Oct-30, Volume: 86

    Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; MCF-7 Cells; Molecular Structure; Pyrimidines; Structure-Activity Relationship; Triazoles

2014
The identification of GPR3 inverse agonist AF64394; the first small molecule inhibitor of GPR3 receptor function.
    Bioorganic & medicinal chemistry letters, 2014, Nov-15, Volume: 24, Issue:22

    Topics: Animals; Drug Inverse Agonism; Mice; Pyrimidines; Receptors, G-Protein-Coupled; Triazoles

2014
Synthesis and anticancer evaluation of novel triazole linked N-(pyrimidin-2-yl)benzo[d]thiazol-2-amine derivatives as inhibitors of cell survival proteins and inducers of apoptosis in MCF-7 breast cancer cells.
    Bioorganic & medicinal chemistry letters, 2015, Feb-01, Volume: 25, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; Caspase 9; Cell Line, Tumor; Cell Survival; Cytochrome P-450 CYP1A1; G2 Phase Cell Cycle Checkpoints; Humans; M Phase Cell Cycle Checkpoints; MCF-7 Cells; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NF-kappa B; Pyrimidines; Structure-Activity Relationship; Thiazoles; Triazoles

2015
Synthesis and Biological Evaluation of a Series of 2-((1-substituted-1H-1,2,3-triazol-4-yl)methylthio)-6-(naphthalen-1-ylmethyl)pyrimidin-4(3H)-one As Potential HIV-1 Inhibitors.
    Chemical biology & drug design, 2015, Volume: 86, Issue:4

    Topics: Anti-HIV Agents; Cell Line; Chemistry Techniques, Synthetic; Drug Evaluation, Preclinical; HIV-1; Humans; Pyrimidines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Triazoles

2015
Design and synthesis of novel 1,2,3-triazole-pyrimidine-urea hybrids as potential anticancer agents.
    Bioorganic & medicinal chemistry letters, 2015, Mar-01, Volume: 25, Issue:5

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Drug Design; Drug Screening Assays, Antitumor; Humans; Neoplasms; Pyrimidines; Structure-Activity Relationship; Triazoles; Urea

2015
Flow synthesis of ethyl isocyanoacetate enabling the telescoped synthesis of 1,2,4-triazoles and pyrrolo-[1,2-c]pyrimidines.
    Organic & biomolecular chemistry, 2015, Apr-14, Volume: 13, Issue:14

    Topics: Acetates; Chemistry Techniques, Synthetic; Models, Molecular; Molecular Conformation; Nitriles; Phosgene; Pyrimidines; Triazoles

2015
Design, Synthesis and Evaluation of Triazole-Pyrimidine Analogues as SecA Inhibitors.
    ChemMedChem, 2016, Jan-05, Volume: 11, Issue:1

    Topics: Adenosine Triphosphatases; Bacterial Proteins; Dose-Response Relationship, Drug; Drug Design; Enzyme Inhibitors; Membrane Transport Proteins; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Molecular Structure; Pyrimidines; SEC Translocation Channels; SecA Proteins; Structure-Activity Relationship; Triazoles

2016
Design and synthesis of a novel class of carbonic anhydrase-IX inhibitor 1-(3-(phenyl/4-fluorophenyl)-7-imino-3H-[1,2,3]triazolo[4,5d]pyrimidin 6(7H)yl)urea.
    Journal of molecular graphics & modelling, 2016, Volume: 64

    Topics: Binding Sites; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Catalytic Domain; Drug Design; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Binding; Pyrimidines; Spectrometry, Fluorescence; Triazoles; Urea

2016
Exploration of 1,2,3-triazole-pyrimidine hybrids as potent reversal agents against ABCB1-mediated multidrug resistance.
    European journal of medicinal chemistry, 2018, Jan-01, Volume: 143

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Pyrimidines; Structure-Activity Relationship; Triazoles; Tumor Cells, Cultured

2018
[1,2,4]Triazolo[1,5-a]pyrimidine derivative (Mol-5) is a new NS5-RdRp inhibitor of DENV2 proliferation and DENV2-induced inflammation.
    Acta pharmacologica Sinica, 2020, Volume: 41, Issue:5

    Topics: Animals; Antiviral Agents; Cell Proliferation; Cells, Cultured; Cricetinae; Dengue; Dengue Virus; Inflammation; Microbial Sensitivity Tests; Molecular Docking Simulation; Pyrimidines; Recombinant Proteins; RNA-Dependent RNA Polymerase; Surface Plasmon Resonance; Triazoles; Viral Nonstructural Proteins

2020
[1,2,3]Triazolo[4,5-d]pyrimidine derivatives incorporating (thio)urea moiety as a novel scaffold for LSD1 inhibitors.
    European journal of medicinal chemistry, 2020, Feb-01, Volume: 187

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Histone Demethylases; Humans; Molecular Docking Simulation; Molecular Structure; Pyrimidines; Structure-Activity Relationship; Triazoles

2020
Nanoencapsulation of a ruthenium(ii) complex with triazolopyrimidine in liposomes as a tool for improving its anticancer activity against melanoma cell lines.
    Dalton transactions (Cambridge, England : 2003), 2020, Jan-28, Volume: 49, Issue:4

    Topics: Antineoplastic Agents; Capsules; Cell Line, Tumor; Coordination Complexes; Humans; Hydrophobic and Hydrophilic Interactions; Liposomes; Melanoma; Nanostructures; Pyrimidines; Ruthenium; Triazoles

2020
Discovery of new [1,2,4] Triazolo[1,5-a]Pyrimidine derivatives that Kill gastric cancer cells via the mitochondria pathway.
    European journal of medicinal chemistry, 2020, Oct-01, Volume: 203

    Topics: Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Drug Design; Humans; Pyrimidines; Reactive Oxygen Species; Stomach Neoplasms; Triazoles

2020
Structure-based non-nucleoside inhibitor design: Developing inhibitors that are effective against resistant mutants.
    Chemical biology & drug design, 2021, Volume: 97, Issue:1

    Topics: Anti-HIV Agents; Binding Sites; Drug Design; Drug Resistance, Viral; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Molecular Dynamics Simulation; Mutation; Pyridones; Pyrimidines; Rilpivirine; Triazoles

2021
Developing novel classes of protein kinase CK1δ inhibitors by fusing [1,2,4]triazole with different bicyclic heteroaromatic systems.
    European journal of medicinal chemistry, 2021, Apr-15, Volume: 216

    Topics: Binding Sites; Blood-Brain Barrier; Casein Kinase Idelta; Cell Line; Cell Survival; Drug Design; Humans; Kinetics; Molecular Docking Simulation; Protein Kinase Inhibitors; Pyrimidines; Static Electricity; Structure-Activity Relationship; Thermodynamics; Triazines; Triazoles

2021
Novel triazole-sulfonamide bearing pyrimidine moieties with carbonic anhydrase inhibitory action: Design, synthesis, computational and enzyme inhibition studies.
    Bioorganic & medicinal chemistry letters, 2021, 09-15, Volume: 48

    Topics: Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Dose-Response Relationship, Drug; Drug Design; Humans; Isoenzymes; Models, Molecular; Molecular Structure; Pyrimidines; Structure-Activity Relationship; Sulfonamides; Triazoles

2021
P2Y14R for inflammation therapy: is it a promising target?
    Future medicinal chemistry, 2021, Volume: 13, Issue:18

    Topics: Anti-Inflammatory Agents; Benzofurans; Benzoic Acid; Biomarkers; Drug Evaluation, Preclinical; Humans; Inflammation; Naphthalenes; Purinergic P2 Receptor Antagonists; Pyrimidines; Receptors, Purinergic P2; Structure-Activity Relationship; Triazoles

2021
Design and synthesis of novel furan, furo[2,3-d]pyrimidine and furo[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives as potential VEGFR-2 inhibitors.
    Bioorganic chemistry, 2021, Volume: 116

    Topics: Cell Cycle Checkpoints; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Furans; Human Umbilical Vein Endothelial Cells; Humans; Molecular Docking Simulation; Molecular Structure; Protein Kinase Inhibitors; Pyrimidines; Structure-Activity Relationship; Triazoles; Vascular Endothelial Growth Factor Receptor-2

2021
Factors Affecting the Stability of Platinum(II) Complexes with 1,2,4-Triazolo[1,5-
    International journal of molecular sciences, 2022, Mar-26, Volume: 23, Issue:7

    Topics: Antineoplastic Agents; Benzene Derivatives; Cell Line, Tumor; Oxides; Platinum; Pyrimidines; Sulfoxides; Thiophenes; Triazoles

2022
Design, Synthesis, α-Amylase/α-Glucosidase Inhibition Assay, Induced Fit Docking Study of New Hybrid Compounds Containing 4H-Pyrano[2,3-d]pyrimidine, 1H-1,2,3-Triazole and D-Glucose Components.
    Chemistry & biodiversity, 2022, Volume: 19, Issue:12

    Topics: alpha-Amylases; alpha-Glucosidases; Amylases; Glucose; Glucosidases; Glycoside Hydrolase Inhibitors; Humans; Molecular Docking Simulation; Molecular Structure; Pyrimidines; Structure-Activity Relationship; Triazoles

2022
Regioselective Synthesis and Molecular Docking Studies of 1,5-Disubstituted 1,2,3-Triazole Derivatives of Pyrimidine Nucleobases.
    Molecules (Basel, Switzerland), 2022, Dec-02, Volume: 27, Issue:23

    Topics: Azides; COVID-19; Humans; Molecular Docking Simulation; SARS-CoV-2; Triazoles

2022