3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole: non-hormonal antifertility agent; RN & N1 from CA Vol 90 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 122000 |
| CHEMBL ID | 18410 |
| SCHEMBL ID | 3500575 |
| MeSH ID | M0495553 |
| Synonym |
|---|
| contragestazol |
| st-1959 , |
| dl-111-it |
| l 14111 |
| dl 111 |
| 1h-1,2,4-triazole, 3-(2-ethylphenyl)-5-(3-methoxyphenyl)- |
| s-triazole, 3-(o-ethylphenyl)-5-(m-methoxyphenyl)- |
| (3-ethylphenyl)-5-(3-methoxyphenyl)-1,2,4-triazole |
| 3-(o-ethylphenyl)-5-(m-methoxyphenyl)-s-triazole |
| dl-111 , |
| l-14111 |
| 5-(2-ethylphenyl)-3-(3-methoxyphenyl)-1h-1,2,4-triazole |
| 5-(2-ethylphenyl)-3-(3-methoxyphenyl)-s-triazole |
| 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1h-1,2,4-triazole |
| dl 111it |
| dl 111-it |
| dl111-it |
| st1959 |
| 69095-83-6 |
| CHEMBL18410 |
| diphenytriazol |
| unii-5hk8o3ma34 |
| 5hk8o3ma34 , |
| SCHEMBL3500575 |
| GXCZZAKPGMYPDJ-UHFFFAOYSA-N |
| 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1h-1,2,4 triazole |
| 5-(2-ethyl-phenyl)-3-(3-methoxy-phenyl)-1h-(1,2,4) triazole |
| dl-111it |
| dl111 |
| 1h-1,2,4-triazole, 5-(2-ethylphenyl)-3-(3-methoxyphenyl)- |
| DTXSID20988816 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "The pharmacokinetic profiles of a new non-hormonal anti-fertility agent, DL 111-IT, were studied in rats and hamsters given the 14C labelled compound parenterally dissolved in aqueous or oily vehicles." | ( Pharmacokinetics-activity relationships of a new non-hormonal antifertility agent: 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H-1, 2,4-triazole, in the rat and the hamster. Assandri, A; Galliani, G; Omodei-Salé, A; Perazzi, A; Sartori, G, 1983) | 0.5 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "To clarify the role of DL111-IT when combined with mifepristone (Mif) on termination of early pregnancy." | ( Synergistic effects on pregnancy-termination activity of DL111-IT in combination with mifepristone. Fang, RY; Yang, B, 1996) | 0.29 |
| "The objectives of this study were to determine the synergistic effects of DL111-IT in combination with mifepristone (RU486) on termination of early pregnancy in rhesus monkeys." | ( Synergistic effects of DL111-IT combined with mifepristone on termination of early pregnancy in rhesus monkeys. Fang, RY; He, QJ; Yang, B; Ying, Y, 2000) | 0.31 |
| "DL111-IT, a non-hormonal contragestional agent, revealed synergistic effects in combination with mifepristone (RU486) in some species." | ( Effects of DL111-IT or combined with RU486 on uterine polyamines biosynthesis in rats during early gestation. Fang, R; He, Q; Shentu, J; Wang, L; Zhou, H, 2001) | 0.31 |
| "This study evaluated the effectiveness and acute toxicity of DL111-IT combined with mifepristone (RU486) and misoprostol (MISO) on early pregnancy termination." | ( Synergistic effects of DL111-IT in combination with mifepristone and misoprostol on termination of early pregnancy in preclinical studies. Fang, RY; He, QJ; Wang, WF; Wu, HH; Yang, B, 2003) | 0.32 |
| Excerpt | Relevance | Reference |
|---|---|---|
| " Most of the members of these series of compounds are effective with a single injection although the dosage can be 5 or more times as large as that needed for each of 5 daily injections." | ( Development of novel embryotoxic compounds for interceptive fertility control in the dog. Lerner, LJ, 1989) | 0.28 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID176615 | Pregnancy-terminating activity in rat when administered po | 1983 | Journal of medicinal chemistry, Aug, Volume: 26, Issue:8 | A new class of nonhormonal pregnancy-terminating agents. Synthesis and contragestational activity of 3,5-diaryl-s-triazoles. |
| AID176616 | Pregnancy-terminating activity in rat when administered sc | 1983 | Journal of medicinal chemistry, Aug, Volume: 26, Issue:8 | A new class of nonhormonal pregnancy-terminating agents. Synthesis and contragestational activity of 3,5-diaryl-s-triazoles. |
| AID84860 | Pregnancy-terminating activity in hamster when administered sc | 1983 | Journal of medicinal chemistry, Aug, Volume: 26, Issue:8 | A new class of nonhormonal pregnancy-terminating agents. Synthesis and contragestational activity of 3,5-diaryl-s-triazoles. |
| AID84858 | Pregnancy-terminating activity in hamster when administered perorally | 1983 | Journal of medicinal chemistry, Aug, Volume: 26, Issue:8 | A new class of nonhormonal pregnancy-terminating agents. Synthesis and contragestational activity of 3,5-diaryl-s-triazoles. |
| AID178499 | Compound was tested for in vitro activity of luteolysis on corpora lutea from pseudopregnant rats | 2002 | Bioorganic & medicinal chemistry letters, Sep-02, Volume: 12, Issue:17 | Non-steroidal pregnancy-terminating agents: design, synthesis and structure-activity relationships of 2-aryl-1,2,4-triazolo[1,5-a]pyridine. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 13 (36.11) | 18.7374 |
| 1990's | 6 (16.67) | 18.2507 |
| 2000's | 16 (44.44) | 29.6817 |
| 2010's | 1 (2.78) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (10.65) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 38 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||