Any hepatotoxic agent capable of inducing liver steatosis or fatty liver disease.
ChEBI ID: 83612
| Member | Definition | Class |
|---|---|---|
| dicarbethoxydihydrocollidine | A dihydropyridine that is 2,4,6-trimethyl-1,4-dihydropyridine substituted by ethoxycarbonyl groups at positions 3 and 5. | 3,5-diethoxycarbonyl-1,4-dihydrocollidine |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 88 (27.59) | 18.7374 |
| 1990's | 41 (12.85) | 18.2507 |
| 2000's | 56 (17.55) | 29.6817 |
| 2010's | 106 (33.23) | 24.3611 |
| 2020's | 28 (8.78) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 6 (1.83%) | 6.00% |
| Case Studies | 1 (0.31%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 320 (97.86%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| acid sphingomyelinase | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 31.8326 | 1 | 2 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 112.2020 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 23.1093 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 112.2020 | 1 | 1 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| WRN | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Oligo-1,6-glucosidase IMA1 | Saccharomyces cerevisiae S288C | IC50 | 50.0000 | 1 | 1 |