Nocturnal Enuresis

Involuntary discharge of URINE during sleep at night after expected age of completed development of urinary control.

Synonym
Nocturnal Enuresis

Excerpt	Reference
"Monosymptomatic nocturnal enuresis is frequently associated with nocturnal polyuria and low urinary osmolality during the night."	( De Guchtenaere, A; Donckerwolcke, R; Hoebeke, P; Raes, A; Van Laecke, E; Van Sintjan, P; Vande Walle, C; Vande Walle, J, 2007)
"Bedwetting (nocturnal enuresis) is not uncommon in childhood but it can have a profound effect on children and their families."	( Dobson, P; Weaver, A, 2007)
"Nocturnal enuresis is a disease with a heterogeneous aetiology and complex pathophysiology."	( Van Laecke, E; Vande Walle, J, 2008)
"Nocturnal enuresis is not diagnosed in children younger than 5 years, and treatment may be inappropriate for children younger than 7 years."	( Kiddoo, D, 2007)
"Nocturnal enuresis is a frequent heterogeneous condition, which is genetically complex in nature."	( Burgu, B; Gökce, MI; Gücük, A; Soygür, T, 2009)
"Monosymptomatic nocturnal enuresis is a common entity, with a prevalence of 10% at the age of 7 years."	( Abedin Zadeh, M; Kholaseh Zadeh, G; Moslemi, MK, 2011)
"Bedwetting (nocturnal enuresis) is a common and distressing condition, both for children and young people and their families, and the National Institute for Health and Clinical Excellence (NICE) has produced its first guidelines for its assessment and treatment in those aged up to 19 years."	( Norfolk, S; Wootton, J, 2010)
"Nocturnal enuresis is defined as involuntary wetting while asleep at least twice a week in children over the age of five."	( Bottomley, G, 2011)
"Nocturnal enuresis is one of the most common problems in childhood."	( Alloussi, S; Schwentner, C; Seibold, J; Stenzl, A; Todenhöfer, T, 2013)
"Primary nocturnal enuresis is a prevalent childhood condition that can persist into adulthood."	( De Bruyne, P; Goble, S; Juul, KV; Nørgaard, JP; Van Herzeele, C; Walle, JV, 2013)
"Bed wetting or nocturnal enuresis is a common problem among children."	( Kanitkar, M; Ramamurthy, HR, 2013)
"Nocturnal enuresis is a prevalent and challenging problem in children and young adults with sickle cell disease (SCD)."	( DeBaun, MR; Goodpaster, RL; Kassim, AA; Wolf, RB, 2014)
"Nocturnal enuresis is a common developmental disorder in children; primary monosymptomatic nocturnal enuresis (PMNE) is the dominant subtype."	( Du, X; Lei, D; Ma, J; Shen, G; Wang, H; Wang, M; Yang, G; Zhang, J, 2014)
"Secondary nocturnal enuresis is generally seen between 5 and 7 years of age and it is rarely encountered when compared with the primary incontinence."	( Akan, S; Sahin, A; Ürkmez, A; Verit, A; Yildirim, C; Yüksel, ÖH, 2015)
"Nocturnal enuresis is a common pediatric condition with limited treatment options."	( Berkenwald, A; Ellsworth, P; Pires, J, 2016)
"Nocturnal enuresis is usually diagnosed and treated by a primary paediatrician or family practitioner; if there is any doubt, the children may be referred to a paediatric urologist."	( Fanos, V; Gasperi, E; Lippi, G; Nosetti, L; Piacentini, G; Zaffanello, M, 2017)
"Nocturnal enuresis is the most common type of urinary incontinence in children."	( Kamperis, K; Préel, M; Rittig, S, 2018)
"Nocturnal enuresis is a common problem that children may present with in a primary care setting."	( Walker, RA, 2019)
"Nocturnal enuresis is a condition, which can affectthe quality of life in children."	( Azarfar, A; Esmaeeli, M; Mostafavian, Z; Ravanshad, S; Ravanshad, Y; Zahabi, E, 2019)
"Nocturnal enuresis is defined as urinary incontinence that occurs at night during sleep in children 5 years or older for 3 consecutive months."	( Sundaram, V, 2020)
"Adult nocturnal enuresis is multifactorial and may have multiple underlying pathologies."	( Katz, EG; MacLachlan, LS, 2020)
"Nocturnal enuresis is one of the side effects of valproic acid treatment, and generally underdiagnosed by clinicians."	( Abdelsalam, M; Bendary, L; Egila, H; Elsherief, M; Esmael, A, 2020)
"Nocturnal enuresis is highly heritable, but its genetic determinants remain unknown."	( Agerbo, E; Als, TD; Børglum, AD; Christensen, JH; Demontis, D; Eðvarðsson, VÖ; Grove, J; Horsdal, HT; Hougaard, DM; Jørgensen, CS; Kamperis, K; Mors, O; Mortensen, PB; Nordentoft, M; Nyegaard, M; Rajagopal, VM; Rittig, S; Stefánsson, H; Stefánsson, K; Walters, GB; Werge, T, 2021)
"Nocturnal enuresis is a common disease of childhood."	( Elawady, H; Mahmoud, MA; Samir, M, 2021)
"Nocturnal enuresis is the involuntary pass of urine during sleep beyond the age of 5 years."	( Kamperis, K, 2021)
"Nocturnal enuresis is defined as nighttime urinary incontinence occurring at least twice weekly in children five years and older."	( Arnold, JJ; Garcia, KW; Lauters, RA, 2022)
"Nocturnal enuresis is defined as nighttime urinary incontinence occurring at least twice weekly in children five years and older."	( Arnold, JJ; Garcia, KW; Lauters, RA, 2022)
"Nocturnal enuresis is defined as nighttime urinary incontinence occurring at least twice weekly in children five years and older."	( Arnold, JJ; Garcia, KW; Lauters, RA, 2022)

Excerpt	Reference
"Nocturnal enuresis has been reported in patients taking clozapine, but the incidence has not been accurately established."	( Ashton, J; Harrison-Woolrych, M; Herbison, P; Skegg, DC; Skegg, K, 2011)
"Nocturnal enuresis has a variety of causes."	( Bachmann, CJ; Bachmann, H; Hoyer, PF; Marschall-Kehrel, D; Schultz-Lampel, D; Steuber, C, 2011)

Excerpt	Reference
"Nocturnal enuresis affects 15-20% of 5-year-old children, 5% of 10 year-old-children and 1-2% of people aged 15 years and over."	( Kiddoo, D, 2007)

Excerpt	Reference
"The use of HCTZ in the treatment of nocturnal enuresis has never been previously evaluated."	( Al-Ghazo, MA; Alawwa, IA; Matani, YS; Saleh, AA, 2010)
"Desmopressin is used for treatment of nocturnal enuresis in children."	( Boussery, K; Colin, P; De Bruyne, P; Dossche, L; Michelet, R; Van Bocxlaer, J; Vande Walle, J; Vermeulen, A, 2016)
"Although the evidence-based treatment for nocturnal enuresis is established, nearly one-third of patients are still enuretic with desmopressin, anti-cholinergic treatment and alarm."	( Ohtomo, Y, 2017)
"Desmopressin is a long-established treatment for nocturnal enuresis with clear guidelines regarding its usage."	( Juul, KV; Mahler, B; Nørgaard, JP; Rittig, S; Schroeder, MK, 2018)
"Most treatments of nocturnal enuresis (NE) are targeting the main pathophysiological mechanisms, i."	( Andersen, RF; Faerch, M; Jørgensen, CS; Kamperis, K; Meyer, SIR; Pedersen, MJ; Rittig, S, 2021)
"The alarm is the first-line treatment of nocturnal enuresis."	( Borgström, M; Karanikas, B; Larsson, J; Nevéus, T, 2023)
"The alarm is the first-line treatment of nocturnal enuresis."	( Borgström, M; Karanikas, B; Larsson, J; Nevéus, T, 2023)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	78 (20.42)	23.3326
1990's	1 (0.26)	12.5806
2000's	84 (21.99)	18.1394
2010's	155 (40.58)	28.8240
2020's	64 (16.75)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	2	0
betaine	low	1	0
creatine	low	1	0
melatonin	medium	1	1
niacinamide	low	1	0
nitrates	low	1	0
thiamine	low	2	0
urea	low	1	0
phenytoin	low	1	0
amitriptyline	low	3	0
baclofen	low	1	0
caffeine	medium	2	1
verapamil	medium	1	1
cefuroxime	low	1	0
chlordiazepoxide	low	8	0
chlorpheniramine	low	1	0
chlorpromazine	low	3	0
citalopram	low	1	0
clonazepam	low	1	0
clonidine	medium	2	2
desipramine	low	1	0
amphetamine	low	7	0
diazepam	low	1	0
valproic acid	low	3	0
doxazosin	medium	1	1
fluoxetine	medium	1	1
furosemide	medium	1	1
guanfacine	low	1	0
hydrochlorothiazide	medium	2	1
hydroxyzine	low	3	0
ibuprofen	medium	1	1
imipramine	medium	28	8
indomethacin	medium	4	2
iproniazid	low	2	0
mebeverine	medium	1	1
meprobamate	low	6	0
methantheline	low	8	0
methylphenidate	medium	7	1
modafinil	low	1	0
nialamide	low	5	0
nortriptyline	medium	1	1
orphenadrine	low	1	0
oxybutynin	medium	21	7
phenmetrazine	low	3	0
propantheline	low	3	0
propiverine	medium	4	1
risperidone	low	7	0
thioridazine	low	1	0
tizanidine	medium	1	1
trihexyphenidyl	low	1	0
reserpine	low	3	0
dextroamphetamine	low	2	0
aldosterone	low	1	0
aspartic acid	low	1	0
desoxycorticosterone	low	1	0
arginine	low	1	0
methylprednisolone	low	1	0
carbazole	low	1	0
pseudoephedrine	medium	2	2
deanol	low	1	0
cyclohexanol	low	1	0
ephedrine	low	3	0
hydantoins	low	1	0
phenylpropanolamine	medium	4	3
d-alpha tocopherol	low	1	0
s,n,n'-tripropylthiocarbamate	medium	2	1
deanol acetamidobenzoate	low	1	0
floxacillin	low	1	0
silver	low	1	0
vasotocin	low	1	0
an 1	medium	1	1
cetylpyridinium chloride anhydrous	medium	1	1
paroxetine	low	2	0
fomesafen	low	5	0
atomoxetine hydrochloride	low	2	0
aripiprazole	low	3	0
venlafaxine hydrochloride	low	1	0
n-acetylaspartic acid	low	1	0
triazoles	low	1	0
sertraline	low	1	0
propyromazine	low	1	0
strychnine n-oxide	low	1	0
reboxetine	medium	1	1
angiotensin ii	medium	1	1
atropine	low	3	0
solifenacin succinate	medium	5	2
strychnine	low	1	0
retinol	low	1	0
arginine vasopressin	medium	12	2
propylthiouracil	low	1	0
chlorprothixene	low	1	0
methimazole	low	1	0
pica	low	1	0
prosultiamine	low	1	0
dinoprostone	low	1	0
phenylephrine hydrochloride	low	3	0
deamino arginine vasopressin	medium	204	51
fluvoxamine	low	1	0
scopolamine hydrobromide	low	1	0
pituitrin	medium	15	1
atrial natriuretic factor	low	1	0
suvorexant	low	1	0
quetiapine fumarate	low	2	0
tolterodine tartrate	medium	6	4
natriuretic peptide, brain	low	4	0
vitamin b 12	low	1	0
exudates	low	3	0
technetium tc 99m dimercaptosuccinic acid	low	2	0
clozapine	low	7	0
olanzapine	low	3	0
pyrimidinones	low	4	0

Protein Targets (903)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
AR protein	37	0	0	37
glucocorticoid receptor [Homo sapiens]	27	0	0	27
thyroid hormone receptor beta isoform a	9	0	0	9
nuclear factor erythroid 2-related factor 2 isoform 2	7	0	0	7
geminin	37	0	0	37
Sex hormone-binding globulin	0	0	2	2
Corticosteroid-binding globulin	0	2	0	2
Mineralocorticoid receptor	0	1	2	3
Androgen receptor	0	3	0	3
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	2
Guanine nucleotide-binding protein G	5	0	0	5
Chain A, HADH2 protein	8	0	0	8
Chain B, HADH2 protein	8	0	0	8
thioredoxin reductase	20	0	0	20
USP1 protein, partial	15	0	0	15
NFKB1 protein, partial	10	0	0	10
GLS protein	17	0	0	17
cytochrome P450 family 3 subfamily A polypeptide 4	22	0	0	22
cytochrome P450 2D6	21	0	0	21
arylsulfatase A	16	0	0	16
cytochrome P450 2D6 isoform 1	15	0	0	15
D(1A) dopamine receptor	17	0	0	17
chromobox protein homolog 1	23	0	0	23
atrial natriuretic peptide receptor 2 precursor	13	0	0	13
serine/threonine-protein kinase mTOR isoform 1	11	0	0	11
nuclear factor erythroid 2-related factor 2 isoform 1	30	0	0	30
muscarinic acetylcholine receptor M1	16	0	0	16
Solute carrier family 22 member 1	0	14	0	17
Polyunsaturated fatty acid lipoxygenase ALOX15B	7	0	0	7
ATP-binding cassette sub-family C member 3	0	34	0	34
Multidrug resistance-associated protein 4	0	34	0	35
Voltage-dependent L-type calcium channel subunit alpha-1F	0	10	0	10
5-hydroxytryptamine receptor 4	0	30	0	30
Bile salt export pump	0	46	0	46
Albumin	0	0	8	8
High affinity nerve growth factor receptor	0	1	2	3
Aldo-keto reductase family 1 member B1	0	25	0	25
Muscarinic acetylcholine receptor M2	0	26	3	33
Muscarinic acetylcholine receptor M4	0	29	2	33
Muscarinic acetylcholine receptor M1	0	10	1	13
Muscarinic acetylcholine receptor M3	0	9	1	12
Muscarinic acetylcholine receptor M4	0	8	1	11
5-hydroxytryptamine receptor 2C	0	17	2	19
Muscarinic acetylcholine receptor M5	0	9	1	12
Muscarinic acetylcholine receptor M5	0	30	1	33
Alpha-2A adrenergic receptor	0	29	2	31
Muscarinic acetylcholine receptor M2	0	10	2	15
Muscarinic acetylcholine receptor M1	0	31	3	38
Angiotensin-converting enzyme	0	23	0	23
D(2) dopamine receptor	0	21	1	26
5-hydroxytryptamine receptor 2A	0	18	2	20
Alpha-2B adrenergic receptor	0	28	1	29
Alpha-2C adrenergic receptor	0	25	2	27
5-hydroxytryptamine receptor 1A	0	28	3	31
Muscarinic acetylcholine receptor M3	0	31	2	35
D(1A) dopamine receptor	0	16	0	18
D(1B) dopamine receptor	0	5	0	7
UDP-glucuronosyltransferase 1A4	0	0	0	5
Sodium-dependent noradrenaline transporter	0	38	5	43
Histamine H2 receptor	0	16	0	16
Alpha-1D adrenergic receptor	0	25	1	27
5-hydroxytryptamine receptor 2A	0	33	0	35
5-hydroxytryptamine receptor 2C	0	33	1	34
5-hydroxytryptamine receptor 1B	0	21	2	23
5-hydroxytryptamine receptor 1D	0	7	2	9
5-hydroxytryptamine receptor 1F	0	7	2	9
5-hydroxytryptamine receptor 2B	0	16	3	19
5-hydroxytryptamine receptor 6	0	4	2	6
Histamine H1 receptor	0	7	0	7
Sodium-dependent serotonin transporter	0	42	6	48
5-hydroxytryptamine receptor 7	0	9	2	11
5-hydroxytryptamine receptor 5A	0	4	2	6
5-hydroxytryptamine receptor 5B	0	4	2	6
Histamine H1 receptor	0	32	3	37
D(3) dopamine receptor	0	23	1	27
Sodium channel protein type 1 subunit alpha	0	4	0	4
Sodium channel protein type 4 subunit alpha	0	4	0	5
UDP-glucuronosyltransferase 1A3	0	0	0	3
5-hydroxytryptamine receptor 3A	0	5	2	7
5-hydroxytryptamine receptor 2B	0	31	1	32
Alpha-1A adrenergic receptor	0	21	3	24
Histamine H2 receptor	14	4	0	22
D(1A) dopamine receptor	9	0	0	9
5-hydroxytryptamine receptor 6	0	20	0	21
5-hydroxytryptamine receptor 7	0	10	0	10
Voltage-dependent N-type calcium channel subunit alpha-1B	0	4	0	4
Sodium channel protein type 7 subunit alpha	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1D	0	10	0	10
Sodium-dependent dopamine transporter	0	33	4	37
Potassium voltage-gated channel subfamily H member 2	0	34	0	34
Voltage-dependent L-type calcium channel subunit alpha-1S	0	10	0	10
Voltage-dependent L-type calcium channel subunit alpha-1C	0	10	0	10
Sodium channel protein type 5 subunit alpha	0	9	0	9
Sodium channel protein type 9 subunit alpha	0	4	0	4
Sigma non-opioid intracellular receptor 1	0	5	1	6
5-hydroxytryptamine receptor 4	0	4	2	6
Nuclear receptor subfamily 3 group C member 3	0	23	0	23
Canalicular multispecific organic anion transporter 1	0	34	0	34
Sodium channel protein type 2 subunit alpha	0	4	0	4
Ataxin-2	20	0	0	20
Sigma non-opioid intracellular receptor 1	0	23	0	23
5-hydroxytryptamine receptor 3B	0	5	2	7
Sodium channel protein type 3 subunit alpha	0	4	0	4
Sodium channel protein type 11 subunit alpha	0	3	0	3
Sodium channel protein type 8 subunit alpha	0	3	0	3
Histamine H3 receptor	0	9	0	9
Sodium channel protein type 10 subunit alpha	0	3	0	3
Solute carrier family 22 member 3	0	3	0	3
Phenylethanolamine N-methyltransferase	0	3	0	4
Cytochrome P450 2A6	0	2	0	2
Substance-P receptor	0	1	0	1
Cytochrome P450 2A5	0	1	0	1
Sodium-dependent dopamine transporter	0	21	1	22
Beta-2 adrenergic receptor	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	9	1	10
glucocerebrosidase	4	0	0	4
DNA polymerase kappa isoform 1	6	0	0	6
histone acetyltransferase KAT2A isoform 1	9	0	0	9
Atrial natriuretic peptide receptor 3	0	1	0	1
Type-1A angiotensin II receptor	0	2	1	3
Type-1 angiotensin II receptor	0	0	1	1
Type-1B angiotensin II receptor	0	2	0	2
Type-1 angiotensin II receptor	0	2	2	4
Type-2 angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	2	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	13	0	0	13
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
phosphopantetheinyl transferase	12	0	0	12
thyroid stimulating hormone receptor	13	0	0	13
alpha-galactosidase	2	0	0	2
euchromatic histone-lysine N-methyltransferase 2	38	0	0	38
cytochrome P450 2C19 precursor	10	0	0	10
flap endonuclease 1	7	0	0	7
DNA polymerase iota isoform a (long)	9	0	0	9
lethal factor (plasmid)	9	0	0	9
Cytochrome P450 3A4	0	9	1	13
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	1	0	2
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
ATP-dependent phosphofructokinase	19	0	0	19
vitamin D3 receptor isoform VDRA	11	0	0	11
peripheral myelin protein 22	21	0	0	21
Translocator protein	0	2	2	5
Vasopressin V2 receptor	0	3	2	6
Oxytocin receptor	0	1	2	3
Vasopressin V1a receptor	0	0	2	2
Vasopressin V1a receptor	0	2	2	4
Vasopressin V1b receptor	0	2	2	4
Vasopressin V2 receptor	0	0	1	1
Vasopressin V1b receptor	0	1	1	3
Translocator protein	0	2	0	3
Oxytocin receptor	0	1	0	1
Vasopressin V2 receptor	0	2	2	4
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	13	0	0	13
Chain A, JmjC domain-containing histone demethylation protein 3A	5	0	0	5
5-hydroxytryptamine receptor 3E	0	3	0	3
acetylcholinesterase	11	0	0	11
hypoxia-inducible factor 1 alpha subunit	9	0	0	9
RAR-related orphan receptor gamma	21	0	0	21
SMAD family member 2	7	0	0	7
Fumarate hydratase	6	0	0	6
PPM1D protein	3	0	0	3
SMAD family member 3	7	0	0	7
TDP1 protein	33	0	0	33
GLI family zinc finger 3	33	0	0	33
Microtubule-associated protein tau	13	0	0	13
estrogen receptor 2 (ER beta)	16	0	0	16
nuclear receptor subfamily 1, group I, member 3	26	0	0	26
progesterone receptor	18	0	0	18
EWS/FLI fusion protein	11	0	0	11
retinoic acid nuclear receptor alpha variant 1	31	0	0	31
retinoid X nuclear receptor alpha	25	0	0	25
estrogen-related nuclear receptor alpha	31	0	0	31
farnesoid X nuclear receptor	14	0	0	14
pregnane X nuclear receptor	24	0	0	24
estrogen nuclear receptor alpha	37	0	0	37
G	17	0	0	17
polyprotein	6	0	0	6
67.9K protein	10	0	0	10
peroxisome proliferator-activated receptor delta	15	0	0	15
peroxisome proliferator activated receptor gamma	19	0	0	19
vitamin D (1,25- dihydroxyvitamin D3) receptor	14	0	0	14
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	5	0	0	5
thyroid stimulating hormone receptor	15	0	0	15
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	11	0	0	11
v-jun sarcoma virus 17 oncogene homolog (avian)	17	0	0	17
lysosomal alpha-glucosidase preproprotein	5	0	0	5
mu-type opioid receptor isoform MOR-1	0	0	2	2
potassium voltage-gated channel subfamily H member 2 isoform d	16	0	0	16
transcriptional regulator ERG isoform 3	6	0	0	6
thyroid hormone receptor beta isoform 2	25	0	0	25
heat shock protein beta-1	12	0	0	12
nuclear receptor ROR-gamma isoform 1	11	0	0	11
5-hydroxytryptamine receptor 2A	0	0	2	2
neuropeptide S receptor isoform A	5	0	0	5
Solute carrier family 22 member 2	0	5	0	6
5-hydroxytryptamine receptor 3A	0	2	1	3
Voltage-dependent calcium channel gamma-2 subunit	13	0	0	13
5-hydroxytryptamine receptor 3B	0	3	0	3
Interferon beta	20	0	0	20
HLA class I histocompatibility antigen, B alpha chain	17	0	0	17
Cellular tumor antigen p53	21	0	0	21
ATP-dependent translocase ABCB1	0	10	1	23
5-hydroxytryptamine receptor 1A	0	8	5	13
Neuronal acetylcholine receptor subunit alpha-4	3	3	0	6
Neuronal acetylcholine receptor subunit beta-2	3	3	0	6
Alpha-1B adrenergic receptor	0	16	1	17
D	0	12	0	12
Glutamate receptor 2	13	0	0	13
D(4) dopamine receptor	0	11	0	14
Alpha-1D adrenergic receptor	0	16	1	17
D(4) dopamine receptor	0	11	0	11
Histamine H1 receptor	0	5	0	5
5-hydroxytryptamine receptor 7	0	7	0	7
Alpha-1A adrenergic receptor	0	8	2	11
Alpha-1B adrenergic receptor	0	6	1	8
5-hydroxytryptamine receptor 3A	0	3	0	3
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	4	0	4
Spike glycoprotein	23	1	2	26
D(2) dopamine receptor	0	17	0	18
Inositol monophosphatase 1	9	0	0	9
5-hydroxytryptamine receptor 3D	0	3	0	3
Multidrug and toxin extrusion protein 2	0	4	0	4
5-hydroxytryptamine receptor 3C	0	3	0	3
Inositol hexakisphosphate kinase 1	17	0	0	17
Multidrug and toxin extrusion protein 1	0	8	0	8
cytochrome P450 2C9, partial	17	0	0	17
Chain A, Ferritin light chain	4	0	0	4
aldehyde dehydrogenase 1 family, member A1	15	0	0	15
Bloom syndrome protein isoform 1	9	0	0	9
lamin isoform A-delta10	30	0	0	30
Metabotropic glutamate receptor 6	0	0	1	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate transporter homolog	0	0	1	1
Carbonic anhydrase 1	0	5	0	7
Carbonic anhydrase 2	0	6	0	8
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	0	0	1
Glutamate receptor ionotropic, NMDA 1	0	3	0	3
Excitatory amino acid transporter 1	0	1	0	1
Excitatory amino acid transporter 2	0	1	0	1
Excitatory amino acid transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	3	0	3
Glutamate receptor ionotropic, NMDA 2B	0	3	0	3
Glutamate receptor ionotropic, NMDA 2C	0	3	0	3
Metabotropic glutamate receptor 1	0	0	1	1
Metabotropic glutamate receptor 2	0	0	1	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	3	0	3
Glutamate receptor ionotropic, NMDA 3B	0	3	0	3
Carbonic anhydrase 4	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	3	0	3
glp-1 receptor, partial	9	0	0	9
IDH1	12	0	0	12
Atrial natriuretic peptide receptor 1	0	1	1	2
Atrial natriuretic peptide receptor 1	0	0	1	1
Chain A, 2-oxoglutarate Oxygenase	7	0	0	7
cystic fibrosis transmembrane conductance regulator	0	1	0	1
DNA polymerase beta	5	0	0	5
short transient receptor potential channel 6 isoform 1	0	0	2	2
Muscarinic acetylcholine receptor M1	0	0	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Reverse transcriptase/RNaseH	0	0	0	1
Muscarinic acetylcholine receptor	0	1	2	4
ATAD5 protein, partial	15	0	0	15
regulator of G-protein signaling 4	14	0	0	14
activating transcription factor 6	11	0	0	11
cytochrome P450 3A4 isoform 1	13	0	0	13
Gamma-aminobutyric acid receptor subunit pi	13	9	1	23
Gamma-aminobutyric acid type B receptor subunit 2	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 2	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-1	13	9	1	23
Gamma-aminobutyric acid receptor subunit delta	13	9	1	23
Gamma-aminobutyric acid receptor subunit gamma-2	13	9	3	25
Gamma-aminobutyric acid receptor subunit alpha-5	13	9	1	23
Gamma-aminobutyric acid receptor subunit alpha-3	13	9	1	23
Gamma-aminobutyric acid receptor subunit gamma-1	13	9	1	23
Gamma-aminobutyric acid receptor subunit alpha-2	13	9	1	23
Gamma-aminobutyric acid receptor subunit alpha-4	13	9	1	23
Gamma-aminobutyric acid receptor subunit gamma-3	13	9	1	23
Gamma-aminobutyric acid receptor subunit alpha-6	13	9	1	23
Gamma-aminobutyric acid receptor subunit alpha-1	13	9	3	25
Gamma-aminobutyric acid receptor subunit beta-3	13	9	1	23
Gamma-aminobutyric acid receptor subunit beta-2	13	9	3	25
GABA theta subunit	13	9	1	23
Gamma-aminobutyric acid receptor subunit epsilon	13	9	1	23
Gamma-aminobutyric acid type B receptor subunit 1	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 1	0	2	0	2
Chain A, Betaine ABC transporter permease and substrate binding protein	0	0	1	1
Chain A, Osmoprotection protein (ProX)	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Bile salt export pump	0	10	0	10
Proton-coupled amino acid transporter 1	0	3	0	3
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Chitinase	0	1	0	1
atrial natriuretic peptide receptor 1 precursor	4	0	0	4
Potassium channel subfamily K member 2	0	2	1	3
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	1	0	1
Cholinesterase	0	3	0	3
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Replicase polyprotein 1ab	0	2	2	4
Adenosine receptor A3	0	1	0	1
Replicase polyprotein 1ab	0	3	2	5
Amine oxidase [flavin-containing] A	0	4	0	4
Acetylcholinesterase	0	5	0	5
Adenosine receptor A1	0	6	0	7
Amine oxidase [flavin-containing] B	0	5	0	5
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	2	1	4
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A2b	0	2	1	4
Adenosine receptor A1	0	1	1	4
Adenosine receptor A2a	0	4	1	7
Vasopressin V2 receptor	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	2	0	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	2	2	4
Endochitinase B1	0	1	0	1
Phosphodiesterase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	6	1	7
Guanine deaminase	0	1	0	1
Luciferase	10	0	0	10
ClpP	2	0	0	2
aryl hydrocarbon receptor	10	0	0	10
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	14	0	0	14
Histone H2A.x	10	0	0	10
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
histone deacetylase 9 isoform 3	2	0	0	2
Nuclear receptor ROR-gamma	6	0	0	6
Angiopoietin-1 receptor	0	0	1	1
Histamine H4 receptor	0	3	1	4
caspase 7, apoptosis-related cysteine protease	8	0	0	8
caspase-3	8	0	0	8
thyrotropin-releasing hormone receptor	2	0	0	2
mitogen-activated protein kinase 1	12	0	0	12
survival motor neuron protein isoform d	10	0	0	10
Caspase-2	0	0	1	1
ATPase family AAA domain-containing protein 5	8	0	0	8
Gamma-aminobutyric acid receptor subunit alpha-1	0	4	0	4
Gamma-aminobutyric acid receptor subunit beta-1	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-2	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-3	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-1	0	8	3	11
Gamma-aminobutyric acid receptor subunit gamma-2	0	8	2	10
Gamma-aminobutyric acid receptor subunit alpha-4	0	4	0	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	4	0	4
Gamma-aminobutyric acid receptor subunit beta-3	0	8	2	10
Cholecystokinin receptor type A	0	3	0	3
Gastrin/cholecystokinin type B receptor	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-5	0	8	3	11
Gamma-aminobutyric acid receptor subunit alpha-3	0	8	2	10
Gamma-aminobutyric acid receptor subunit alpha-2	0	8	2	10
MBT domain-containing protein 1	0	2	0	2
Solute carrier family 22 member 1	0	7	0	7
Lethal(3)malignant brain tumor-like protein 4	0	2	0	2
Lethal(3)malignant brain tumor-like protein 3	0	2	0	2
Chloroquine resistance transporter	0	2	0	2
Solute carrier family 22 member 2	0	5	0	5
Lethal(3)malignant brain tumor-like protein 1	0	2	0	2
Proteasome subunit beta type-11	0	0	0	1
Thrombopoietin	5	0	0	5
Smad3	5	0	0	5
NADPH oxidase 1	0	1	0	1
Snq2p	0	0	0	4
Adenylate cyclase type 1	0	3	0	3
Caspase-7	4	0	0	4
Spike glycoprotein	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
cellular tumor antigen p53 isoform a	3	0	0	3
caspase-3	4	0	0	4
ras-related protein Rab-9A	8	0	0	8
M-phase phosphoprotein 8	10	0	0	10
Proteasome subunit alpha type-7	0	0	0	1
Transmembrane protease serine 2	0	1	2	3
Glutamate receptor ionotropic, NMDA 2D	0	2	0	2
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	2	0	2
Epidermal growth factor receptor	0	4	0	4
Albumin	0	5	6	12
Major prion protein	0	0	2	2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Major prion protein	0	0	1	1
Integrin beta-3	3	0	0	3
Cytochrome P450 1A2	0	2	1	4
Tyrosine-protein kinase Fyn	0	2	0	2
Procathepsin L	0	2	2	4
Integrin alpha-IIb	3	0	0	3
Replicase polyprotein 1a	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	3	1	4
Cytochrome P450 2D6	0	14	1	16
Cytochrome P450 2C9	0	13	0	14
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
Sphingomyelin phosphodiesterase	0	2	0	2
D(3) dopamine receptor	0	11	0	11
Alpha-2B adrenergic receptor	0	15	1	16
D(2) dopamine receptor	0	3	0	3
Proteasome subunit beta type-1	0	0	0	1
Substance-K receptor	0	2	0	2
Adenylate cyclase type 3	0	3	0	3
Alpha-2C adrenergic receptor	0	15	1	16
Alpha-2A adrenergic receptor	0	15	1	16
D(1B) dopamine receptor	0	9	0	9
Proteasome subunit alpha type-1	0	0	0	1
Proteasome subunit alpha type-2	0	0	0	1
Proteasome subunit alpha type-3	0	0	0	1
Proteasome subunit alpha type-4	0	0	0	1
Adenylate cyclase type 2	0	3	0	3
Adenylate cyclase type 4	0	3	0	3
Proteasome subunit beta type-8	0	0	0	1
Proteasome subunit beta type-9	0	0	0	1
Proteasome subunit alpha type-5	0	0	0	1
Proteasome subunit beta type-4	0	0	0	1
Proteasome subunit beta type-6	0	0	0	1
Proteasome subunit beta type-5	0	0	0	1
Trypanothione reductase	0	2	0	2
Melanocortin receptor 4	0	2	0	2
Melanocortin receptor 5	0	4	0	4
Pleiotropic ABC efflux transporter of multiple drugs	0	4	0	8
Mu-type opioid receptor	0	6	0	6
Adenylate cyclase type 8	0	3	0	3
Proteasome subunit beta type-10	0	0	0	1
Delta-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	4	0	4
Melanocortin receptor 3	0	2	0	2
Proteasome subunit beta type-3	0	0	0	1
Proteasome subunit beta type-2	0	0	0	1
Cytochrome P450 2J2	0	10	0	11
Gastrin/cholecystokinin type B receptor	0	2	0	2
Proteasome subunit alpha type-6	0	0	2	3
Calmodulin	0	1	2	3
Aldehyde oxidase 1	0	1	0	1
Adenylate cyclase type 6	0	3	0	3
Adenylate cyclase type 5	0	3	0	3
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Aldehyde oxidase	0	2	0	4
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	2	0	2
Adenylyl cyclase 7	0	3	0	3
Proteasome subunit alpha-type 8	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	2	0	2
D	0	3	0	3
Proteasome subunit beta type-7	0	0	0	1
Angiotensin-converting enzyme 2	0	1	2	3
Chain A, Beta-lactamase	5	0	0	5
importin subunit beta-1 isoform 1	5	0	0	5
snurportin-1	5	0	0	5
Chain A, Cruzipain	6	0	0	6
endonuclease IV	4	0	0	4
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor 1	0	1	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	6	0	0	6
PINK1	1	0	0	1
Parkin	3	0	0	3
bromodomain adjacent to zinc finger domain 2B	6	0	0	6
estrogen receptor beta isoform 1	0	1	0	1
GTP-binding nuclear protein Ran isoform 1	3	0	0	3
Cruzipain	0	1	0	1
NPC intracellular cholesterol transporter 1 precursor	6	0	0	6
Sodium-dependent noradrenaline transporter	0	4	0	4
Tryptophan 5-hydroxylase 1	0	4	0	4
Aldo-keto reductase family 1 member B1	0	4	0	4
Aromatase	0	1	0	1
Sodium-dependent serotonin transporter	0	14	2	16
Sigma intracellular receptor 2	0	7	0	7
Sodium-dependent serotonin transporter	0	4	0	4
Sodium-dependent dopamine transporter	0	4	0	4
Transporter	0	16	0	16
Gamma-aminobutyric acid receptor subunit pi	0	7	0	7
Gamma-aminobutyric acid receptor subunit delta	0	7	0	7
Gamma-aminobutyric acid receptor subunit beta-1	0	7	1	8
Translocator protein	0	2	0	2
Translocator protein	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-2	0	7	2	9
Gamma-aminobutyric acid receptor subunit alpha-4	0	7	1	8
Gamma-aminobutyric acid receptor subunit epsilon	0	7	0	7
Gamma-aminobutyric acid receptor subunit alpha-6	0	7	1	8
Gamma-aminobutyric acid receptor subunit gamma-1	0	7	0	7
Gamma-aminobutyric acid receptor subunit gamma-3	0	7	0	7
Gamma-aminobutyric acid receptor subunit theta	0	7	0	7
Beta-1 adrenergic receptor	0	1	1	2
Alpha-1B adrenergic receptor	0	0	2	2
cytochrome P450 2C9 precursor	9	0	0	9
Membrane primary amine oxidase	0	1	0	1
Solute carrier family 22 member 3	0	4	0	4
Alpha-1A adrenergic receptor	0	1	2	3
Alpha-2B adrenergic receptor	0	0	0	1
Delta-type opioid receptor	0	3	0	3
Mu-type opioid receptor	0	3	0	3
Alpha-2C adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Nischarin	0	2	0	2
Nischarin	0	3	0	3
peripheral myelin protein 22 isoform 1	7	0	0	7
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Beta-2 adrenergic receptor	0	2	0	2
Beta-1 adrenergic receptor	0	2	0	2
Endothelin receptor type B	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
Endothelin receptor type B	0	1	0	1
Beta-3 adrenergic receptor	0	1	0	1
Cytochrome P450 2C19	0	6	0	8
5-hydroxytryptamine receptor 2C	0	3	0	3
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 5A	0	1	0	1
D(2) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	1	0	1
D(2) dopamine receptor	0	3	0	3
5-hydroxytryptamine receptor 2B	0	2	0	2
5-hydroxytryptamine receptor 4	0	1	0	1
Transporter	0	5	0	5
Cholecystokinin receptor type A	0	1	0	1
5-hydroxytryptamine receptor 1A	0	2	0	2
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Rap guanine nucleotide exchange factor 3	3	0	0	3
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
Choline O-acetyltransferase	0	1	0	1
huntingtin isoform 2	5	0	0	5
Prostaglandin G/H synthase 1	0	6	0	7
Histamine H3 receptor	0	1	0	1
Solute carrier family 22 member 4	0	1	0	1
GALC protein	3	0	0	3
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
TAR DNA-binding protein 43	3	0	0	3
Amine oxidase [flavin-containing] B	0	2	0	2
Amine oxidase [flavin-containing] B	0	1	0	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Gamma-aminobutyric acid	0	2	1	3
Fatty acid-binding protein, liver	0	2	0	2
Alpha-1-acid glycoprotein 1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit delta	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-3	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	1	3
Gamma-aminobutyric acid receptor subunit pi	0	2	1	3
Sphingosine-1-phosphate lyase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	1	3
Gamma-aminobutyric acid receptor subunit theta	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	1	3
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
prostaglandin E2 receptor EP2 subtype	1	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Prostaglandin E2 receptor EP3 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	2	0	2
Prostaglandin E2 receptor EP1 subtype	0	2	1	3
Prostaglandin E2 receptor EP1 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin F2-alpha receptor	0	0	1	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP3 subtype	0	2	1	3
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Prostacyclin receptor	0	2	1	3
Solute carrier organic anion transporter family member 2A1	0	1	0	2
Solute carrier family 22 member 6	0	2	0	3
Solute carrier family 22 member 7	0	0	0	2
Prostaglandin E2 receptor EP2 subtype	0	2	0	2
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 20	0	3	0	3
Solute carrier family 22 member 8	0	2	0	3
Solute carrier family 22 member 6	0	3	0	3
Solute carrier family 22 member 7	0	0	0	1
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier family 22 member 11	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Interstitial collagenase	0	1	0	1
Beta-2 adrenergic receptor	0	2	0	2
Alpha-synuclein	2	1	0	3
Solute carrier family 15 member 1	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Cytochrome P450 2C8	0	3	0	3
Dipeptidyl peptidase 4	0	1	0	1
Acetylcholinesterase	0	1	0	1
Prostaglandin G/H synthase 1	0	3	0	3
Potassium voltage-gated channel subfamily C member 1	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Cytochrome P450 1B1	0	2	0	2
Cytochrome P450 1A2	0	2	0	2
Solute carrier family 22 member 6	0	4	0	4
Carbonic anhydrase 12	0	2	0	3
Carbonic anhydrase 3	0	2	0	2
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Carbonic anhydrase 4	0	3	0	4
Carbonic anhydrase 6	0	3	0	4
Serum paraoxonase/arylesterase 1	0	2	0	2
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	2	0	3
Carbonic anhydrase 7	0	2	0	3
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Carbonic anhydrase 9	0	2	0	3
Carbonic anhydrase 13	0	2	0	3
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Carbonic anhydrase 14	0	2	0	3
Carbonic anhydrase 5B, mitochondrial	0	2	0	3
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	2
Hsf1 protein	0	0	3	4
histone-lysine N-methyltransferase 2A isoform 2 precursor	4	0	0	4
Histone deacetylase 3	0	3	0	3
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	3
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Histone deacetylase 4	0	3	0	3
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Histone deacetylase 1	0	3	0	3
Sterol O-acyltransferase 1	0	0	1	1
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	3	0	3
Polyamine deacetylase HDAC10	0	3	0	3
Histone deacetylase 11	0	3	0	3
Histone deacetylase 8	0	3	0	3
Platelet glycoprotein VI	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Histone deacetylase 6	0	3	0	3
Histone deacetylase 9	0	3	0	3
Histone deacetylase 5	0	3	0	3
POU domain, class 2, transcription factor 1	0	0	0	1
Glycogen synthase kinase-3 alpha	0	1	0	1
Glycogen synthase kinase-3 beta	0	1	0	1
Protein cereblon	0	2	0	2
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	4	0	4
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
nonstructural protein 1	4	0	0	4
muscleblind-like protein 1 isoform 1	3	0	0	3
Acid-sensing ion channel 3	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	3
Prostaglandin G/H synthase 2	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Albumin	0	1	0	1
Fatty acid-binding protein, intestinal	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	4
UDP-glucuronosyltransferase 2B7	0	1	0	3
Prostaglandin G/H synthase 1	0	2	0	2
Caspase-1	0	1	0	2
Substance-P receptor	0	2	0	2
Prostaglandin G/H synthase 2	0	3	1	4
Prostaglandin G/H synthase 2	0	2	0	3
Aldo-keto reductase family 1 member C3	0	3	0	3
Caspase-3	0	1	0	1
Caspase-4	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Caspase-5	0	1	0	1
Caspase-9	0	1	0	1
Acid-sensing ion channel 1	0	1	0	1
Prostaglandin G/H synthase 2	0	4	0	4
Fatty-acid amide hydrolase 1	0	2	0	2
Prostaglandin G/H synthase 2	0	2	0	3
Prostaglandin G/H synthase 1	0	2	0	3
Dehydrogenase/reductase SDR family member 9	0	1	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	4	0	0	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	4	0	4
Envelope glycoprotein	0	0	3	3
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
interleukin 8	6	0	0	6
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin E synthase	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Cytochrome c oxidase subunit 2	0	1	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
Interleukin-8	0	1	0	1
Androgen receptor	0	0	1	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Thromboxane-A synthase	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Multidrug resistance-associated protein 1	0	3	1	5
Bifunctional epoxide hydrolase 2	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
C-X-C chemokine receptor type 3	0	2	0	2
Aldo-keto reductase family 1 member C2	0	1	0	1
Prostaglandin D2 receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A3	0	1	0	1
Lactoylglutathione lyase	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	2
Cytosolic phospholipase A2 gamma	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
Solute carrier organic anion transporter family member 1B1	0	4	0	4
Amine oxidase [flavin-containing] A	0	1	0	1
Cytochrome P450 1A1	0	1	0	1
Myeloperoxidase	0	3	0	3
Cytochrome P450 2C11	0	1	0	1
Aromatase	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Metabotropic glutamate receptor 1	0	1	0	1
Acetylcholinesterase	0	1	0	1
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Carboxylic ester hydrolase	0	1	0	1
Polyphenol oxidase 2	0	2	0	3
Dopamine beta-hydroxylase	0	2	0	2
Lactoperoxidase	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Glucocorticoid receptor	0	2	0	2
Glycine receptor subunit alpha-1	0	3	0	3
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
thioredoxin glutathione reductase	2	0	0	2
Rap guanine nucleotide exchange factor 4	1	0	0	1
Chain A, NAD-dependent deacetylase	0	1	0	1
Poly [ADP-ribose] polymerase 2	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Coagulation factor VII	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
Tissue factor	0	2	0	2
Cytochrome P450 3A5	0	1	0	1
NAD-dependent protein deacetylase HST2	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
NAD(+) hydrolase SARM1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	2	0	2
NAD-dependent protein deacetylase	0	1	0	1
apical membrane antigen 1, AMA1	1	0	0	1
N-glycosylase/DNA lyase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Sodium/iodide cotransporter	0	1	0	1
Carbonic anhydrase 15	0	1	0	1
dopamine D1 receptor	1	0	0	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Cytochrome P450 2D4	0	1	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Amyloid-beta precursor protein	0	2	0	2
Quinolone resistance protein NorA	0	2	0	3
Beta-adrenergic receptor kinase 1	0	1	0	1
Potassium voltage-gated channel subfamily A member 3	0	2	0	2
Beta-adrenergic receptor kinase 1	0	1	1	2
Substance-P receptor	0	1	0	1
Rhodopsin kinase GRK1	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
P2X purinoceptor 4	0	1	0	1
Rhodopsin kinase GRK1	0	1	0	1
P2X purinoceptor 4	0	1	0	1
Beta-adrenergic receptor kinase 1	0	0	0	1
beta-2 adrenergic receptor	1	0	0	1
Vpr	1	0	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Synaptic vesicle glycoprotein 2A	0	1	0	1
NADH-cytochrome b5 reductase 3	0	1	0	1
Thyroid peroxidase	0	1	0	1
Taste receptor type 2 member 38	0	0	1	2
RGS12	1	0	0	1
15-lipoxygenase, partial	3	0	0	3
pyruvate kinase	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	1	0	0	1
pyruvate kinase PKM isoform b	1	0	0	1
Ornithine decarboxylase	1	0	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-2	0	1	0	1
hemoglobin subunit beta	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
caspase-1 isoform alpha precursor	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
ATP-dependent translocase ABCB1	0	2	0	2
DNA topoisomerase 1	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	3
Chromaffin granule amine transporter	0	1	0	1
Caspase-7	1	0	0	1
Synaptic vesicular amine transporter	0	1	0	1
Synaptic vesicular amine transporter	0	2	1	3
Synaptic vesicular amine transporter	0	1	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
pregnane X receptor	2	0	0	2
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Glycine receptor subunit alpha-1	0	2	1	3
Transcriptional activator protein LuxR	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Glycine receptor subunit beta	0	1	0	1
Taste receptor type 2 member 46	0	0	1	1
Taste receptor type 2 member 10	0	0	1	2
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
Dihydropteroate synthase	0	1	0	1
Transcriptional activator protein LasR	0	1	0	1
Endothelin-1 receptor	0	1	0	1
Endothelin-1 receptor	0	1	0	1
Protein arginine N-methyltransferase 6	0	1	0	1
Orexin receptor type 1	0	2	0	2
Orexin receptor type 2	0	2	0	2
Orexin receptor type 1	0	1	0	1
Orexin receptor type 2	0	1	0	1
Substance-K receptor	0	1	0	1
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
Cathepsin D	0	1	0	1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0	1	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Cocaine esterase	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	0	0	1
Liver carboxylesterase 1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
Glycoprotein	0	1	0	1
Muscarinic acetylcholine receptor M2	0	0	1	1
Catechol O-methyltransferase	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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Studies (382)

Protein Targets (903)

Nocturnal Enuresis

Synonyms(1)

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Research

Studies (382)

Drugs Studied (124)

Protein Targets (903)