Compounds > perfluoropentanoic acid
Page last updated: 2024-11-06

perfluoropentanoic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Perfluoropentanoic acid (PFPeA) is a highly fluorinated carboxylic acid that has garnered significant attention for its potential environmental and health impacts. It is a persistent organic pollutant that can bioaccumulate in organisms, and studies have linked it to various adverse effects. PFPeA is primarily produced as a byproduct of industrial processes involving fluorinated chemicals, such as the manufacture of fluoropolymers. Its unique chemical properties, including its high stability and lipophilicity, make it resistant to degradation in the environment, leading to its persistence and accumulation in the food chain. Researchers study PFPeA due to its potential toxicity to humans and wildlife, and they are investigating its fate and transport in the environment. Moreover, the development of effective remediation strategies for PFPeA contamination is crucial for safeguarding human health and the environment.'
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perfluoropentanoic acid: an ion-pairing agent [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

perfluoropentanoic acid : A monocarboxylic acid that is perfluorinated pentanoic acid. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID75921
CHEMBL ID173263
CHEBI ID83491
SCHEMBL ID64889

Synonyms (45)

Synonym
luw3uy784p ,
unii-luw3uy784p
einecs 220-300-7
nsc 18404
pentanoic acid, 2,2,3,3,4,4,5,5,5-nonafluoro-
perfluoro-n-pentanoic acid
nonafluoro-1-pentanoic acid
pentanoic acid, nonafluoro-
nsc-18404
perfluorovaleric acid
valeric acid, nonafluoro-
2706-90-3
nsc18404
perfluoropentanoic acid
2,2,3,3,4,4,5,5,5-nonafluoro-pentanoic acid
nonafluoropentanoic acid
inchi=1/c5hf9o2/c6-2(7,1(15)16)3(8,9)4(10,11)5(12,13)14/h(h,15,16
nonafluoro-valeric acid
perfluoropentanoic acid, 97%
nonafluorovaleric acid
ipc-pffa-5
2,2,3,3,4,4,5,5,5-nonafluoropentanoic acid
chebi:83491 ,
CHEMBL173263
N0605
AKOS005258165
n-perfluoropentanoic acid
FT-0634452
pentanoic acid,2,2,3,3,4,4,5,5,5-nonafluoro-
SCHEMBL64889
CS-B0902
DTXSID6062599 ,
c5hf9o2
2,2,3,3,4,4,5,5,5-nonafluoropentanoic acid #
mfcd00040211
J-016667
pfpea
Q27156873
perfluoro-n-pentanoic acid 50 microg/ml in methanol/water
perfluoropentanoic acid 100 microg/ml in methanol/water
FS-4216
D82040
perfluoro-n-pentanoic acid 50 microg/ml in methanol/water
nonafluoropentanoic acid, nonafluorovaleric acid, perfluoropentanoic acid
1ST9515

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
" Long-chain PFASs are ubiquitous in wildlife and are reported to have a long elimination half-life in biological systems."( Gender differences in pharmacokinetics of perfluoropentanoic acid using non-linear mixed-effect modeling in rats.
Cho, HY; Choi, EJ; Choi, GW; Kang, DW; Kim, JH; Lee, YB, 2020)		0.82

Bioavailability

ExcerptReferenceRelevance
" In this study, sequential extraction of PFAAs in soil and bioaccumulation of PFAAs in earthworm were carried out to understand the sequestration and bioavailability of PFAAs in soils with different soil organic matter (SOM) and aged for different time periods (7 and 47d)."( Sequestration and bioavailability of perfluoroalkyl acids (PFAAs) in soils: Implications for their underestimated risk.
Ma, X; Zhao, L; Zhao, S; Zhu, L, 2016)		0.43
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
environmental contaminantAny minor or unwanted substance introduced into the environment that can have undesired effects.
xenobioticA xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
fluoroalkanoic acidAny organofluorine compound that is the perfluorinated derivative of any alkanoic acid.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID111187Percent plasma glucose concentration of drug treated mice (ob/ob) relative to vehicle control animals following 75 mg/kg administration.1992Journal of medicinal chemistry, Mar-06, Volume: 35, Issue:5
Perfluorocarbon-based antidiabetic agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (9.09)18.2507
2000's0 (0.00)29.6817
2010's5 (45.45)24.3611
2020's5 (45.45)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 36.68

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index36.68 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index4.56 (4.65)
Search Engine Demand Index45.89 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (36.68)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
1-aminobenzotriazole
[no description available]		2.2110
ciglitazone
ciglitazone: structure given in second source; PPAR agonist used for type II diabetes. ciglitazone : An aromatic ether that consists of 1,3-thiazolidine-2,4-dione with position 5 substituted by a 4-[(1-methylcyclohexyl)methoxy]benzyl group. A selective PPARgamma agonist.		1.9810aromatic ether;
thiazolidinone		antineoplastic agent;
insulin-sensitizing drug
levodopa
Levodopa: The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. It is rapidly taken up by dopaminergic neurons and converted to DOPAMINE. It is used for the treatment of PARKINSONIAN DISORDERS and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system.. L-dopa : An optically active form of dopa having L-configuration. Used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's disease		2.1510amino acid zwitterion;
dopa;
L-tyrosine derivative;
non-proteinogenic L-alpha-amino acid		allelochemical;
antidyskinesia agent;
antiparkinson drug;
dopaminergic agent;
hapten;
human metabolite;
mouse metabolite;
neurotoxin;
plant growth retardant;
plant metabolite;
prodrug
trichloroacetic acid
Trichloroacetic Acid: A strong acid used as a protein precipitant in clinical chemistry and also as a caustic for removing warts.. trichloroacetic acid : A monocarboxylic acid that is acetic acid in which all three methyl hydrogens are substituted by chlorine.		2.2110monocarboxylic acid;
organochlorine compound		carcinogenic agent;
metabolite;
mouse metabolite
trifluoroacetic acid
Trifluoroacetic Acid: A very strong halogenated derivative of acetic acid. It is used in acid catalyzed reactions, especially those where an ester is cleaved in peptide synthesis.. trifluoroacetic acid : A monocarboxylic acid that is the trifluoro derivative of acetic acid.		2.2110fluoroalkanoic acidhuman xenobiotic metabolite;
NMR chemical shift reference compound;
reagent
perfluorooctanoic acid
perfluorooctanoic acid: RN given refers to parent cpd. perfluorooctanoic acid : A fluoroalkanoic acid that is perfluorinated octanoic acid.		2.4320fluoroalkanoic acidcarcinogenic agent;
endocrine disruptor;
environmental contaminant;
surfactant;
xenobiotic
perfluorobutyric acid
perfluorobutyric acid: ion pairing reagent; RN given refers to parent cpd. perfluorobutyric acid : A monocarboxylic acid that is perfluorinated butyric acid.		3.2350fluoroalkanoic acidchromatographic reagent;
environmental contaminant;
xenobiotic
malondialdehyde
Malondialdehyde: The dialdehyde of malonic acid.. malonaldehyde : A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form.		2.1710dialdehydebiomarker
perfluoropropionic acid
perfluoropropionic acid: ion pairing reagent; RN given refers to parent cpd		2.2110
triazoles
Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.		2.21101,2,3-triazole
perfluorohexanoic acid
perfluorohexanoic acid : A monocarboxylic acid that is perfluorinated hexanoic acid.		7.7220fluoroalkanoic acidenvironmental contaminant;
xenobiotic
perfluoro-n-heptanoic acid
perfluoroheptanoic acid : A fluoroalkanoic acid that is perfluorinated heptanoic acid.		2.7630fluoroalkanoic acidenvironmental contaminant;
xenobiotic
perfluoro-n-nonanoic acid
perfluorononanoic acid : A fluoroalkanoic acid that is nonanoic acid in which all of the hydrogens in the alkyl chain are replaced by fluorines.		1.9810fluoroalkanoic acidpersistent organic pollutant;
surfactant;
xenobiotic
perfluorooctane sulfonic acid
perfluorooctane-1-sulfonic acid : A perfluoroalkanesulfonic acid that is octane-1-sulfonic acid in which all seventeen of the hydrogens that are attached to carbons hvae been replaced by fluorines.		2.2110perfluoroalkanesulfonic acidantilipemic drug;
persistent organic pollutant
sulfluramid
sulfluramid: delayed-action insecticide against the cockroach Dyctyoptera; Blattelidae germanica. sulfluramid : A sulfonamide obtained by the formal condensation of perfluorooctane-1-sulfonic acid with ethylamine.		1.9810sulfonamideacaricide;
environmental contaminant;
insecticide;
xenobiotic
caprylates
Caprylates: Derivatives of caprylic acid. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain a carboxy terminated eight carbon aliphatic structure.. octanoate : A straight-chain saturated fatty acid anion that is the conjugate base of octanoic acid (caprylic acid); believed to block adipogenesis.		2.1710fatty acid anion 8:0;
straight-chain saturated fatty acid anion		human metabolite;
Saccharomyces cerevisiae metabolite
carbidopa
Carbidopa: An inhibitor of DOPA DECARBOXYLASE that prevents conversion of LEVODOPA to dopamine. It is used in PARKINSON DISEASE to reduce peripheral adverse effects of LEVODOPA. It has no anti-parkinson activity by itself.. carbidopa : The hydrate of 3-(3,4-dihydroxyphenyl)propanoic acid in which the hydrogens alpha- to the carboxyl group are substituted by hydrazinyl and methyl groups (S-configuration). Carbidopa is a dopa decarboxylase inhibitor, so prevents conversion of levodopa to dopamine. It has no antiparkinson activity by itself, but is used in the management of Parkinson's disease to reduce peripheral adverse effects of levodopa.		2.1510
ConditionIndicatedRelationship StrengthStudiesTrials
Alloxan Diabetes
[description not available]		01.9810
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		04.2190