Page last updated: 2024-12-06

rp 59227

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

RP 59227: platelet activating factor antagonist [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID65927
CHEMBL ID64449
SCHEMBL ID9120809
SCHEMBL ID10691923
MeSH IDM0178951

Synonyms (25)

Synonym
bdbm50038766
rp 59228
3-pyridin-3-yl-1h-pyrrolo[1,2-c]thiazole-7-carboxylic acid (3-benzoyl-phenyl)-amide
rp 59227
59227-rp
tulopafant
OPREA1_615499
PDSP1_000729
PDSP2_000719
CHEMBL64449 ,
rp-58467
n-(3-benzoylphenyl)-3-pyridin-3-yl-1,3-dihydropyrrolo[1,2-c][1,3]thiazole-7-carboxamide
SCHEMBL9120809
116289-53-3
SCHEMBL10691923
CS-6662
HY-101594
(+)-n-(3-benzoylphenyl)-3-(3-pyridyl)-1h,2h-pyrrolo[1,2-c]thiazole-7-carboxamide
n-(3-benzoylphenyl)-3-(3-pyridyl)-1h,3h-pyrrolo[1,2-c]thiazole-7-carboxamide
PQQFNXGONTVQLM-UHFFFAOYSA-N
n-(3-benzoylphenyl)-3-(pyridin-3-yl)-1h,3h-pyrrolo[1,2-c]thiazole-7-carboxamide
(+)-n-(3-benzoylphenyl)-3-(pyridin-3-yl)-1h,3h-pyrrolo[1,2-c]thiazole-7-carboxamide
DTXSID70869601
n-(3-benzoylphenyl)-3-(pyridin-3-yl)-1h,3h-pyrrolo[1,2-c][1,3]thiazole-7-carboxamide
AKOS040742787

Research Excerpts

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Platelet-activating factor receptorCavia porcellus (domestic guinea pig)Ki0.03180.00040.33863.2500AID154449
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID154449Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand1994Journal of medicinal chemistry, Jun-24, Volume: 37, Issue:13
3-(2-(3-Pyridinyl)thiazolidin-4-oyl)indoles, a novel series of platelet activating factor antagonists.
AID176972In vivo antagonist activity for PAF-Induced cutaneous vascular permeability in the rat1994Journal of medicinal chemistry, Jun-24, Volume: 37, Issue:13
3-(2-(3-Pyridinyl)thiazolidin-4-oyl)indoles, a novel series of platelet activating factor antagonists.
AID132753In vivo antagonist activity against PAF-Induced paw edema in the mouse1994Journal of medicinal chemistry, Jun-24, Volume: 37, Issue:13
3-(2-(3-Pyridinyl)thiazolidin-4-oyl)indoles, a novel series of platelet activating factor antagonists.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's10 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.88

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.88 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.88)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (9.09%)5.53%
Reviews1 (9.09%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (81.82%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]