Page last updated: 2024-12-07

propionyl-coenzyme a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Propionyl-CoA is a crucial intermediate in various metabolic pathways, including the metabolism of branched-chain amino acids (valine, isoleucine, and threonine), odd-chain fatty acids, and the catabolism of certain amino acids like methionine and threonine. It is synthesized from propionate through the action of propionyl-CoA synthetase, an enzyme that utilizes ATP and coenzyme A to convert propionate into propionyl-CoA. Propionyl-CoA is then further metabolized through a series of enzymatic reactions known as the propionate pathway, ultimately leading to the production of succinyl-CoA, which enters the citric acid cycle. The propionate pathway is essential for the complete oxidation of propionate and the generation of energy. Propionyl-CoA is also involved in the biosynthesis of certain essential compounds, such as heme, a component of hemoglobin. The study of propionyl-CoA is important for understanding various metabolic disorders, including propionic acidemia, a rare genetic disorder characterized by the accumulation of propionyl-CoA due to a deficiency in propionyl-CoA carboxylase, an enzyme involved in the propionate pathway. Propionyl-CoA is also studied in relation to other metabolic diseases, such as diabetes and obesity, as it plays a role in lipid metabolism and glucose homeostasis.'

propionyl-coenzyme A: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID92753
CHEBI ID15539
SCHEMBL ID25252
MeSH IDM0053442

Synonyms (39)

Synonym
s-propanoyl-coa
CHEBI:15539
s-propionylcoenzyme a
3'-phosphoadenosine 5'-(3-{(3r)-3-hydroxy-2,2-dimethyl-4-oxo-4-[(3-oxo-3-{[2-(propanoylsulfanyl)ethyl]amino}propyl)amino]butyl} dihydrogen diphosphate)
s-propionyl-coenzym-a
propanoyl-coenzyme a
s-propanoyl-coenzyme a
1vu ,
propionyl coa
n-propionyl coa
9h-purin-6-amine,9-[5-o-[hydroxy[[hydroxy[[(3r)-3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-oxo-3-[[2-[(1-oxopropyl)thio]ethyl]amino]propyl]amino]butyl]oxy]phosphinyl]oxy]phosphinyl]-3-o-phosphono-beta-d-ribof
coenzyme a, s-propanoate
coenzyme a, s-propionate
317-66-8
C00100
C02843
propionyl-coenzyme a
long-chain acyl-coa
PROPIONYL-COA ,
propionyl coenzyme a
DB02912
s-[2-[3-[[(2r)-4-[[[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] propanethioate
unii-h7hqa57v5h
einecs 206-266-6
h7hqa57v5h ,
{[(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-4-hydroxy-2-({[hydroxy({hydroxy[(3r)-3-hydroxy-2,2-dimethyl-3-[(2-{[2-(propanoylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]propoxy]phosphoryl}oxy)phosphoryl]oxy}methyl)oxolan-3-yl]oxy}phosphonic acid
gtpl5248
SCHEMBL25252
125527-27-7
LMFA07050364
DTXSID10185594
alpha-methylacetyl-coa
2-methylacetyl-coenzyme a
alpha-methylacetyl-coenzyme a
2-methylacetyl-coa
s-{(3s,5s,9r)-1-[(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} propanethioate (non-pr
Q2640914
propionyl-coenzyme a; (acyl-coa); [m+h]+;
propionylcoenzymea
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (3)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
Escherichia coli metaboliteAny bacterial metabolite produced during a metabolic reaction in Escherichia coli.
mouse metaboliteAny mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
acyl-CoAA thioester that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any carboxylic acid.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (30)

PathwayProteinsCompounds
Metabolism14961108
Metabolism of lipids500463
Fatty acid metabolism113203
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism1041
alpha-linolenic acid (ALA) metabolism1031
Mitochondrial Fatty Acid Beta-Oxidation2260
Propionyl-CoA catabolism39
Peroxisomal lipid metabolism2552
Beta-oxidation of pristanoyl-CoA922
Metabolism of steroids111135
Bile acid and bile salt metabolism3171
Synthesis of bile acids and bile salts2068
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol1644
Amino acid and derivative metabolism250260
Branched-chain amino acid catabolism2031
Propanoate metabolism ( Propanoate metabolism )2222
NAD+ + CoA + (S)-Methyl-malonate semialdehyde => NADH + Propanoyl-CoA + CO2 ( Valine,Leucine and Isoleucine degradation )16
Propanoyl-CoA + Acceptor = Propenoyl-CoA + Reduced acceptor ( Valine,Leucine and Isoleucine degradation )22
Valine,Leucine and Isoleucine degradation ( Valine,Leucine and Isoleucine degradation )2936
methylmalonyl pathway09
valine degradation I018
isoleucine degradation I018
superpathway of threonine metabolism034
pyruvate fermentation to propionate I015
Valine, leucine and isoleucine degradation034
Biochemical pathways: part I0466
Valproic acid pathway022
Amino acid metabolism094
Beta-alanine biosynthesis II118
Valine degradation817

Research

Studies (194)

TimeframeStudies, This Drug (%)All Drugs %
pre-199037 (19.07)18.7374
1990's36 (18.56)18.2507
2000's45 (23.20)29.6817
2010's56 (28.87)24.3611
2020's20 (10.31)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 54.91

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index54.91 (24.57)
Research Supply Index5.29 (2.92)
Research Growth Index4.68 (4.65)
Search Engine Demand Index91.05 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (54.91)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews9 (4.55%)6.00%
Case Studies5 (2.53%)4.05%
Observational0 (0.00%)0.25%
Other184 (92.93%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]