triazoles has been researched along with Disease Models, Animal in 708 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (0.85) | 18.7374 |
| 1990's | 60 (8.47) | 18.2507 |
| 2000's | 169 (23.87) | 29.6817 |
| 2010's | 414 (58.47) | 24.3611 |
| 2020's | 59 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Gong, W; Jiang, Y; Kong, D; Liu, H; Miao, X; Wu, Z | 1 |
| Chen, Y; He, X; Huang, F; Li, Y; Liu, J; Liu, W; Ma, X; Pan, T; Peng, Z; Qiao, Y; Song, Z; Wang, G; Wu, S; Xia, B; Xu, H; Yuan, Y; Zhang, H; Zhang, X; Zhang, Y; Zhou, M | 1 |
| Amero, P; Bayraktar, E; Coleman, RL; Dasari, SK; Glassman, D; Handley, KF; Ivan, C; Joseph, R; Kim, M; Landesman, Y; Ma, S; Nguyen, N; Powell, RT; Ram, PT; Rodriguez-Aguayo, C; Sobieski, M; Sood, AK; Stephan, C; Stur, E; Umamaheswaran, S; Wen, Y; Westin, SN | 1 |
| Beesley, J; Gause, WC; Haskó, G; Lovászi, M; Németh, ZH; Pacher, P | 1 |
| Ding, H; El-Ashram, S; Ji, Y; Liu, M; Ren, C; Shen, J; Tian, J; Wang, X; Yang, X | 1 |
| Bomsztyk, K; Goryca, K; Kopczynski, M; Kulecka, M; Majewska, E; Masiejczyk, M; Mikula, M; Ostrowski, J; Pysniak, K; Pyziak, K; Rumienczyk, I; Rzymski, T; Sandowska-Markiewicz, Z; Statkiewicz, M; Wojcik-Jaszczynska, K; Wojcik-Trechcinska, U | 1 |
| Gong, W; Jiang, Y; Kong, D; Liu, C; Miao, X; Tian, R; Wang, X; Wang, Y; Wu, Z; Yu, X; Zhu, X | 1 |
| Chen, X; Jia, M; Liu, W; Meng, Z; Sun, W; Tian, S; Wang, Y; Zhou, Z; Zhu, W | 1 |
| Ari, C; Brunner, B; D'Agostino, DP; Kovács, Z | 1 |
| Benedyk-Machaczka, M; Blø, M; Chen, TJ; Furriol, J; Gausdal, G; Kalucka, U; Kamińska, M; Lorens, J; Marti, HP; Mydel, P; Osman, T | 1 |
| Babaei, P; Badrikoohi, M; Esmaeili-Bandboni, A | 1 |
| Allocca, G; Chu, J; Cornthwaite-Duncan, L; Daykin, H; Hoyer, D; Jacobson, LH; Keenan, RJ | 1 |
| An, N; Fan, X; Hua, T; Kong, E; Li, J; Li, Y; Song, H; Wang, H; Yuan, H | 1 |
| Begum, R; Garcia-Ocaña, A; Li, Y; Palit, SP; Parmar, N; Patel, R; Rathwa, N | 1 |
| Bhattacharya, D; Buckley, D; Crowley, R; Duke, G; Friedman, SL; Kemble, G; Martins, EB; O'Farrell, M | 1 |
| Alves, D; Fronza, MG; Praticò, D; Sacramento, M; Savegnago, L | 1 |
| Chi, P; Hong, Z; Shi, H; Sun, Y | 1 |
| Caldas, IS; Carvalho, DT; de Souza, TB; Dias, DF; Paula, FR; Rodrigues, CC | 1 |
| Costagliola, S; De Deken, X; Dumont, JE; Gillotay, P; Giusti, N; Opitz, R; Trubiroha, A | 1 |
| Aresté, C; Colell, A; Coll, M; Cristóbal, H; Cucarull, B; de Gregorio, E; García de Frutos, P; Gausdal, G; Graupera, I; Lorens, JB; Marí, M; Morales, A; Tutusaus, A | 1 |
| Adam, M; Casale, MS; Fraenkel, E; Kedaigle, AJ; Lim, RG; Reidling, JC; Stocksdale, JT; Thompson, LM; Wassie, B; Wu, J | 1 |
| Koo, KT; Lee, BC; Na, J; Pangeni, R; Park, JW | 1 |
| Bossu, A; van Weperen, VYH; Vos, MA | 1 |
| Gamo, FJ; Lafuente-Monasterio, MJ; Lukens, AK; Luth, MR; Magan, N; Mandt, REK; Ottilie, S; Pablos-Tanarro, A; Sakata-Kato, T; Segura, D; Viera, S; Winzeler, EA; Wirth, DF | 1 |
| Fukui, K; Nangaku, M; Saito, H; Sugahara, M; Tanaka, T; Uchida, L; Wakashima, T | 1 |
| Dou, JP; Liang, P; Liu, FY; Yu, J; Zhai, HY; Zhou, QF; Zhu, XY | 1 |
| Chen, W; Hong, J; Huang, D; Huang, Y; Kepler, CK; Li, S; Liang, A; Markova, DZ; Xu, K; Yan, J; Ye, W; Zhou, J | 1 |
| Beck, KR; Odermatt, A; Telisman, L; Thompson, GR; van Koppen, CJ | 1 |
| Bojar, H; Florek-Łuszczki, M; Lepiech, J; Plech, T; Walczak, A; Wróblewska-Łuczka, P; Zagaja, M; Łuszczki, JJ | 1 |
| Díaz, ML; Echeverría, LE; Eduardo Nieto, J; González, CI; Hernandez, JCM; López-Romero, LA; Morillo, CA; Ochoa, SAG; Rivera, JD; Rojas, LZ; Suárez, EU | 1 |
| Bachand, K; Boudreau, D; De Koninck, Y; Doyon, N; Ferrini, F; Gagnon, M; Girard, AA; Godin, AG; Kianicka, I; Labrecque, S; Lorenzo, LE; Plasencia-Fernandez, I; Ribeiro-da-Silva, A | 1 |
| An, H; Heo, JS; Hong, CP; Hong, E; Kang, JM; Kim, SJ; Lee, S; Ooshima, A; Park, J; Park, JO; Park, S; Park, SH | 1 |
| Breur, M; Bugiani, M; Buil, LCM; de Gooijer, MC; Hashizume, R; Hulleman, E; Kaspers, GJL; Koster, J; Lagerweij, T; Meel, MH; Metselaar, DS; Montero Carcaboso, Á; Phoenix, TN; Raabe, EH; Sewing, ACP; Twisk, JWR; van Tellingen, O; van Vuurden, DG; Waranecki, P; Wedekind, LE; Zwaan, K | 1 |
| Cai, HY; He, YX; Li, YY; Qi, JS; Wang, C; Wang, ZJ; Wu, MN; Yan, XD; Zhang, J; Zhou, F | 1 |
| Costa, E; Hannas, BR; Johnson, KJ; LaRocca, J; Sriram, S | 1 |
| Abd Eldaim, MA; Abdallah, AEM; Abdel-Daim, MM; Abdelaziz, SAM; Abdul Rashid, S; Abdullah, AS; Abdullah, LC; Abramson, MJ; Ahmed, HB; Ahmed, MM; Ahn, YC; Alexander, DC; Ando, T; Angelone, AM; Anglani, F; Ap, Y; Arthanari, SK; Axelrad, C; Bai, S; Bakonyi, P; Barnes, E; Beckmann, NA; Bélafi-Bakó, K; Bennett, CM; Bestha, RM; Bitsch, RG; Bradley, CA; Bu, Y; Calò, LA; Cañedo-Villaroya, E; Carlson, L; Caruso, S; Casado-Flores, J; Ceol, M; Cesarino, I; Chen, IL; Chen, R; Chen, X; Chilvers, MI; Cho, WK; Choong, TSY; Conceição-Neto, N; Culver, EL; Dai, X; de Lama Caro-Patón, G; De Rosa, I; Del Prete, D; Dharmage, SC; Dimitriadis, E; Dittakavi, S; Dobrowolski, JC; Edin, S; Elgarawany, GE; Emam, HE; Emmens, RW; Erbas, B; Erwich, JJHM; Farghali, M; Feng, L; Funston, RN; Gabler, NK; Gale, P; Ganesh, M; Gao, J; Gao, L; Gao, X; García-Salido, A; Gatto, R; Gautam, S; Ge, C; Ghogomu, SM; Gianesello, L; Gonçales, VR; Gooch, JL; Gooding, JJ; Gourley, GG; Gu, H; Gu, X; Gu, Z; Guerreri, M; Guillén, M; Hazzaa, SM; Heylen, E; Hicks, R; Hong, X; Hoshi, M; Hu, B; Hu, LX; Hu, R; Hu, S; Huang, J; Huang, K; Hubbard, WB; Hui, J; Hwang, NY; Iannacci, J; Ianus, A; Iglesias-Bouzas, MI; Ihara, I; Iwasaki, M; Jaeger, S; Kandel, YR; Karpińska, G; Kim, HK; Klopfenstein, TJ; Knorr, D; Koók, L; Kotb, S; Kruithof, S; Larsson, P; Laurence, C; Leng, J; Li, H; Li, J; Li, Q; Li, S; Li, X; Li, Z; Lian, J; Liang, JX; Liang, X; Lighaam, LC; Lin, CW; Lin, HC; Lin, J; Ling, A; Liu, J; Liu, P; Liu, YS; Ljuslinder, I; Lo, GH; Lodge, CJ; Löfgren-Burström, A; Lowe, AJ; Lu, M; Lu, N; Lucero-Prisno, DE; Luebbe, KM; Luo, X; Ma, Z; Maes, P; Makuch, M; Malekbala, MR; Mao, Z; Martínez-Romera, I; Marzo, G; Mathew, FM; Mattei, A; Matthijnssens, J; Mayumi, M; Morita, N; Mueller, DS; Mullangi, R; Mummolo, S; Murthi, P; Myte, R; Nabeshima, T; Nakamoto, K; Nehdi, IA; Nemestóthy, N; Niessen, HWM; Noh, JM; Nota, A; Nunes, D; Oh, D; Öhlund, D; Olsen, KM; Ono, H; Osawa, Y; Palmqvist, R; Palombo, M; Park, M; Patience, JF; Peng, Y; Perng, DS; Persano, A; Priante, G; Prince, SJ; Pulipati, S; Pyo, H; Qiu, X; Quan, J; Quaranta, F; Quinzi, V; Rademacher, CJ; Rajaraman, G; Rashid, U; Rauch, JC; Rector, A; Remmerswaal, EBM; Ren, R; Rispens, T; Rocha, GS; Saad, NM; Saito, K; Salamova, A; Sarfaraz, K; Satoshi, A; Schnellmann, RG; Scholpa, NE; Schonhoff, M; Schwartz, KJ; Schwarze, M; Schweer, WP; Seiichi, Y; Serrano-González, A; Severino, J; Shemesh, N; Shi, ZQ; Shike, DW; Shim, YM; Siciliano, PA; Siebenrock, KA; Silva, MKL; Smith, DL; Soltani, S; Song, YM; Spry, ML; Stalker, LA; Stokes, RS; Sullivan, PG; Sun, JM; Sun, S; Svanes, C; Syo, K; Tai, CM; Takashima, S; Tashita, C; Taurino, A; Ten Berge, IJM; Tenuta, AU; Teo, SH; Tilley, RD; Trivedi, RK; Umetsu, K; Unger, PA; van Bruggen, R; van Ham, SM; Van Ranst, M; Vanitha, J; Vekaria, HJ; Venier, M; Venkateshwaran, K; Venkert, A; Vermeulen, E; Wan, C; Wang, H; Wang, N; Wang, P; Wang, T; Wang, X; Wang, Y; Wise, KA; Wolbink, GJ; Wu, J; Wu, P; Wu, S; Wu, Y; Xia, Q; Xin, W; Xiong, Q; Xu, H; Xu, P; Xue, S; Yamamoto, Y; Yamashiro, T; Yan, F; Yan, H; Yan, S; Yan, Y; Yang, JM; Yang, L; Yang, P; Ye, W; Yeh, JH; Yinda, CK; Ying, GG; Ying, L; Yoon, HG; Yu, H; Zainuddin, M; Zakkula, A; Zeller, M; Zeng, Y; Zha, J; Zhang, F; Zhang, H; Zhang, M; Zhang, Q; Zhang, S; Zhang, T; Zhang, Z; Zhao, C; Zhao, J; Zhao, Y; Zhong, Q; Zhu, J; Zingmark, C; Zo, JI; Zou, Y | 1 |
| Bautista, A; Dai, X; Ferdaoussi, M; Lin, H; Lyon, J; MacDonald, PE; Manning Fox, JE; Smith, N; Spigelman, AF | 1 |
| Alenina, N; Bader, M; Dias-Júnior, NM; Eleutério-Silva, MA; Ferreira-Neves, VP; Moura, FA; Nunes-Souza, V; Rabelo, LA | 1 |
| Bauersachs, J; Daniel, JM; Dutzmann, J; Gegel, S; Haertlé, M; Kalies, K; Kloss, F; Knöpp, K; Musmann, RJ; Pilowski, C; Sedding, DG; Sieweke, JT; Sirisko, M | 1 |
| Bodduluri, S; Lyv, X; Rowe, SM; Sanders, YY; Stanford, D; Thannickal, VJ; Xiang, Z; Zhou, QJ | 1 |
| Engesser, J; Fleischer, V; Harpf, V; Lackner, M; Lass-Flörl, C; Maier, H; Meinitzer, A; Rambach, G; Speth, C | 1 |
| Jin, L; Kuang, Y; Liu, P; Yin, M; Zhang, M; Zhu, W | 1 |
| Abruzzo, GK; Apgar, JM; Balkovec, JM; Dragovic, J; Fan, W; Flattery, AM; Galgoci, AM; Giacobbe, RA; Gill, CJ; Greenlee, ML; Hsu, MJ; Kahn, JN; Kirwan, R; Lee, S; Liberator, P; Liu, H; Mamai, A; Meng, D; Misura, AS; Motyl, M; Nelson, K; Parker, DL; Peel, M; Powles, M; Racine, F; Sperbeck, D; Wildonger, KJ; Wilkening, RR | 1 |
| Alle, T; Ballatore, C; Brunden, KR; Lee, VM; Maimaiti, S; Nzou, G; Trojanowski, JQ; Tsering, W; Yao, Y | 1 |
| Calvet, CM; Hirata, K; McKerrow, JH; Silva, TA; Siqueira-Neto, JL; Suzuki, B; Thomas, D | 1 |
| Kittikulsuth, W; Li, L; Morisawa, N; Nakano, D; Nishiyama, A; Ohsaki, H; Suzuki, N; Yamamoto, M; Zhang, A | 1 |
| Krishnamurthy, S; Prajapati, SK | 1 |
| Bottino, C; Caretti, G; Filippakopoulos, P; Fittipaldi, R; Mamchaoui, K; Nevi, L; Segatto, M; Szokoll, R | 1 |
| Chen, J; Chen, LF; Chiang, CM; Hu, X; Jung, H; Kemper, B; Kemper, JK; Sun, H; Wu, SY | 1 |
| Cheng, L; Dai, Q; Feng, W; Sun, F; Xia, P; Yang, B; Yang, M; Yu, M; Yuan, Q | 1 |
| Finkelman, MA; Katragkou, A; Kovanda, LL; Maung, BBW; Moradi, PW; Naing, E; Petraitiene, R; Petraitis, V; Sussman-Straus, GE; Walsh, TJ | 1 |
| Archana, A | 1 |
| Hirakawa, S; Inagaki, K; Nagai, H; Nakamura, A | 1 |
| Bertrand, M; Boutin, JA; Dupuis, P; Ferry, G; Frankiewicz, L; Galibert, M; Gloanec, P; Jullian, M; Ko, A; Le Diguarher, T; Pecquery, A; Puget, K; Ripoll, L | 1 |
| Cao, W; Chen, L; Deng, Y; Li, M; Li, W; Liu, J; Mao, M; Shi, M; Yang, H; Zhang, Y; Zhong, X; Zu, X | 1 |
| Bennett, JM; Chen, Z; Cook, DN; Gopinatth, V; Jacobson, KA; Jung, YH; Karcz, TP; Lieberman, DI; Phung, NB; Randle, JCR; Salmaso, V; Salvemini, D; Wen, Z | 1 |
| Almansa, C; Álvarez, I; Álvarez-Bercedo, P; Cendán, CM; Cobos, EJ; Cuevas, F; Díaz, JL; Enrech, R; Font, D; López-Valbuena, JM; Montero, A; Oliva, AI; Pérez, P; Pericàs, MA; Sarmentero, MÁ; Vela, JM; Vidal-Torres, A; Yeste, S | 1 |
| Been, JH; Cho, J; Choi, K; Choi, S; Choi, SW; Han, J; Jiang, W; Kim, D; Kim, KL; Kim, S; Lee, SK; Oh, J; Park, C; Seo, S; Suh, W | 1 |
| Kitada, K; Kittikulsuth, W; Konishi, Y; Morikawa, T; Morisawa, N; Nakano, D; Nishiyama, A; Rahman, A; Zhang, A | 1 |
| Liang, Y; Zhou, Y | 1 |
| Funakoshi, Y; Hongu, T; Ishitsuka, A; Kanaho, Y; Kawaguchi, A; Kuroki, T; Lee, S; Lin, YH; Nagata, K; Shibuya, A | 1 |
| Bilecki, W; Chmelova, M; Maćkowiak, M; Majcher-Maślanka, I; Wawrzczak-Bargieła, A | 1 |
| Azam, MA; Kusha, M; Labos, C; Lai, PF; Massé, S; Nair, GK; Nanthakumar, K; Tan, NS; Zamiri, N | 1 |
| Benrick, A; Carlström, M; Cushman, SW; Fornes, R; Hu, M; Ivarsson, N; Maciel, GAR; Maliqueo, M; Marcondes, RR; Stener-Victorin, E; Stenkula, KG | 1 |
| Bianchetti, E; Halatsch, ME; Ishida, CT; Karpel-Massler, G; Shu, C; Siegelin, MD; Westhoff, MA | 1 |
| Bai, W; Chen, JF; Chen, X; Chen, XY; Li, P; Liu, D; Ning, YL; Peng, Y; Wang, H; Yang, N; Zhao, Y; Zhao, ZA; Zhou, YG | 1 |
| Antunes, E; Bonilla-Becerra, SM; Calmasini, FB; de Oliveira, MG; Rojas-Moscoso, JA; Zanesco, A | 1 |
| Chen, Z; Doyle, TM; Grenald, SA; Largent-Milnes, TM; Salvemini, D; Slosky, LM; Spiegel, S; Vanderah, TW; Zhang, H | 1 |
| Ertan, M; Kazkayasi, I; Sert-Ozgur, S; Somuncuoglu, EI; Tel, BC; Tozkoparan, B | 1 |
| Bermúdez-Silva, FJ; Cobo-Vuilleumier, N; Espinosa-Jiménez, V; Gauthier, BR; Gómez-Conde, AI; Persaud, SJ; Rafacho, A; Romero-Zerbo, SY; Ruz-Maldonado, I; Sánchez-Salido, L; Tinahones, FJ | 1 |
| Austin, ED; Brittain, EL; Chen, X; Farber-Eger, EH; Fessel, JP; Hemnes, AR; Loyd, JE; Talati, M; West, J | 1 |
| Ahn, JH; Cho, JH; Kim, IH; Kim, SK; Lee, JC; Lee, TK; Lee, YJ; Ohk, TG; Park, CW; Park, JH; Seo, JY; Shin, BN; Shin, MC; Won, MH | 1 |
| Hajnal, A; Horvath, N; Jamis, C; Orellana, ER | 1 |
| Bábíčková, J; Borbélyová, V; Celec, P; Domonkos, E; Hodosy, J; Kačmárová, M; Ostatníková, D; Tóthová, Ľ; Uličná, O | 1 |
| Gryboś, A; Głuch-Lutwin, M; Jóźwiak, K; Kaproń, B; Karcz, T; Mordyl, B; Nowak, G; Pająk, K; Paneth, A; Plech, T; Siwek, A; Tomczykowski, A; Wujec, M; Łuszczki, J | 1 |
| Harasawa, T; Kawai, T; Komatsu, H; Kurimoto, E; Maruyama, M; Nishiyama, K; Sakuma, K; Shimizu, Y; Shimojo, M; Suzuki, H; Suzuki, N | 1 |
| Baloglu, E; Ding, LW; Doan, NB; Ganesan, TS; Garg, M; Kanojia, D; Kauffman, M; Koeffler, HP; Mayakonda, A; Nagare, RP; S, S; Sadhanandhan, B; Said, JW; Shacham, S; Suresh, S | 1 |
| Donvito, G; Fox, TE; Hsu, KL; Kester, M; Lichtman, AH; Schurman, LD; Shin, M; Snyder, HW | 1 |
| Lewis, RE; Verweij, PE | 1 |
| Abla, N; Haas, H; Keiser, J; Reimers, N; Spangenberg, T; Vargas, M | 1 |
| Belardinelli, L; El-Bizri, N; Li, CH; Liu, GX; Rajamani, S | 1 |
| Camerino, GM; Cantatore, P; Conte, E; Cormio, A; Fehrentz, JA; Fonzino, A; Fracasso, F; Lezza, AMS; Liantonio, A; Martinez, J; Musicco, C; Pesce, V; Rizzi, L; Sirago, G; Torsello, A | 1 |
| Shen, JC; Zhang, YC; Zhao, MF | 1 |
| Campos, MC; Clark, TG; Francisco, AF; Kelly, JM; Lewis, MD; Pain, A; Phelan, J; Taylor, MC | 1 |
| Bedin Denardi, L; de Azevedo, MI; Hartz Alves, S; Keller, JT; Morais Santurio, J; Oliveira, V; Pantella Kunz de Jesus, F; Weiblen, C | 1 |
| Arnoletti, JP; Bradner, JE; Christein, JD; Council, LN; Cui, X; Gamblin, TL; Garcia, PL; Heslin, MJ; Miller, AL; Reddy, S; Richardson, JH; van Waardenburg, RCAM; Yang, ES; Yoon, KJ | 1 |
| Chang, J; Liu, B; Liu, Y; Lu, J; Ma, H; Peng, Y; Qiao, Y; Song, C; Wang, J; Wu, J; Yu, W | 1 |
| Fritz, J; Hagleitner, M; Jukic, E; Lackner, M; Lass-Flörl, C; Rambach, G; Sartori, B; Seger, C; Speth, C | 1 |
| Abagyan, R; Aksenov, A; Calvet, CM; Debnath, A; Jennings, G; Luth, MR; McKerrow, JH; Nes, WD; Podust, LM; Zhou, W | 1 |
| Betz, W; Bial, J; Billman, Z; Camargo, N; Campo, B; Charman, SA; Chuenchob, V; Fishbaugher, M; Flannery, EL; Foquet, L; Kappe, SH; Lee, J; Mikolajczak, SA; Murphy, SC; Navarro, MJ; Nguyen, T; Olsen, TM; Phillips, MA; Sack, BK; Saunders, J; Schafer, C; Wilson, EM | 1 |
| Cheng, Z; Gao, Z; Li, P; Ni, P; Sun, G; Wang, X; Yuan, T; Zhou, X | 1 |
| Dong, W; Liang, J; Qi, J; Yu, P; Zhang, T; Zhu, C | 1 |
| Deneka, AY; Gaponova, A; Golemis, EA; Hensley, HH; Kiseleva, AA; Kopp, MC; Korobeynikov, V; Nikonova, AS; Proia, DA; Seeger-Nukpezah, TN; Serebriiskii, IG; Somlo, S | 1 |
| Bernardo, I; Blanco, JR; Narro, J; Ochoa-Callejero, L; Oteo, JA; Pérez-Martínez, L; Rubio-Mediavilla, S | 1 |
| Chen, JF; Li, P; Ning, YL; Peng, Y; Yang, N; Zeng, XJ; Zhao, Y; Zhao, ZA; Zhou, YG | 1 |
| Malik, S; Mellon, PL; Ryan, GE | 1 |
| Dai, XW; Fu, LL; Li, DD; Ma, YL; Ming, H; Xu, X; Xu, Y; Zhang, GQ; Zhang, JS; Zhang, XY; Zheng, LW | 1 |
| Bahia, MT; Caldas, IS; Diniz, LF; Mazzeti, AL; Ribeiro, I | 1 |
| Bode, A; Grubbs, CJ; Juliana, MM; Lubet, RA; Moeinpour, F; Steele, VE | 1 |
| Abid, A; Afsar, T; Almajwal, A; Jahan, S; Khalid, S; Razak, S; Shaheen, G | 1 |
| Jung, DH; Ko, BS; Lee, D; Lee, HW; Pyun, BJ; Sohn, E; Yang, H; Yu, SY | 1 |
| Hu, H; Liu, W; Wen, X; Wu, D; Ye, B; Zhou, Y | 1 |
| Dong, Z; Liu, J; Sun, L; Yuan, Y; Zhang, X | 1 |
| Baker, EM; George, AL; Hawkins, NA; Kearney, JA; Meisler, MH; Patel, MK; Thompson, CH; Wagnon, JL; Wengert, ER | 1 |
| Cheng, SY; Park, S; Qi, J; Willingham, MC | 1 |
| Binder, U; Grässle, D; Hörtnagl, C; Lackner, M; Lass-Flörl, C; Maurer, E; Moser, P; Naschberger, V; Segal, E; Semis, M | 1 |
| Baek, S; Cho, ML; Choi, SS; Hong, SM; Jang, SG; Kwok, SK; Lee, J; Min, JW; Park, SH | 1 |
| Ahmad, HM; Belaghzal, H; Bushweller, JH; Castilla, LH; Dekker, J; Hegde, M; Illendula, A; Muller-Tidow, C; O'Hagan, K; Ou, J; Pulikkan, JA; Wolfe, SA; Yu, J; Zhu, LJ | 1 |
| Chen, KY; Fagin, JA; Ghossein, R; Knauf, JA; Luckett, KA; Socci, ND; Voza, F | 1 |
| Baltazar, LM; Costa-Orlandi, CB; Friedman, AJ; Friedman, JM; Mendes-Giannini, MJS; Mordorski, B; Nosanchuk, JD | 1 |
| Li, E; Li, J; Li, M; Lv, B; Ren, K; Yang, G; Zhuo, Y | 1 |
| Ayad, NG; Choi, JS; Lee, HE; Lee, JK; Rudman, MD; Tan, SK | 1 |
| Acquaviva, J; Bear, MD; Bechtel, SA; Bernabe, LF; Gardner, HL; London, CA; Ogawa, LS; Proia, DA; Sequeira, M; Smith, DL | 1 |
| Choi, EY; Kim, DK; Kim, KY; Kim, MT; Lim, YJ; Park, JH; Song, HY; Tsauo, J; Yoon, SH | 1 |
| Alberola, A; Arias-Mutis, O; Chorro, FJ; Del Canto, I; Genovés, P; Parra, G; Santamaría, L; Soler, C; Such, L; Such-Miquel, L; Tormos, Á; Zarzoso, M | 1 |
| Bajorat, R; Goerss, D; Goßla, E; Kirschstein, T; Köhling, R; Kuhn, J; Porath, K; Sellmann, T | 1 |
| Agnihotri, S; Aldape, KD; Bunda, S; Burrell, K; Chen, EX; Jalali, S; Karimi, S; Kumar, S; Li, M; Liu, J; Mamatjan, Y; Mansouri, A; Mansouri, S; Nejad, R; Singh, O; Singh, SK; Vartanian, A; Zadeh, G | 1 |
| Colon, BL; Guy, RK; Kyle, DE; Rice, CA | 1 |
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| Balkovec, JM; Hermanowski-Vosatka, A; Mundt, S; Olson, SH; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zhu, Y; Zokian, H | 1 |
| Balkovec, JM; Dragovic, J; Graham, D; Hermanowski-Vosatka, A; Mundt, S; Olson, SH; Patel, G; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zhu, Y; Zokian, H | 1 |
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| Kozuki, K; Miyauchi, H; Ohashi, N; Tanio, T | 1 |
| Balsa, D; Ferrando, R; Forn, J; Garcia-Rafanell, J; Giral, M; Merlos, M | 1 |
| Egido, J; González, E; Gutierrez, S; Herrero-Beaumont, G; Miguélez, R; Navarro, F; Palacios, I; Sanchez-Pernaute, O | 1 |
| Fujimura, M; Matsuda, T; Myou, S; Songür, N; Tsujiura, M | 1 |
| Hitchcock, CA; Martin, MV; Yates, J | 1 |
| Canarelli, JP; Cordonnier, C; de Boissieu, D; Dupont, C; Léké, A; Postel, JP; Richard, S; Tarrade, T | 1 |
| Heuer, HO; Jennewein, HM; Urich, K; Wenz, B | 1 |
| Cluzel, J; Doly, M; Droy-Lefaix, MT; Menerath, JM | 1 |
| Chen, J; Giri, SN; Ziboh, V | 1 |
| Cumberbatch, MJ; Hargreaves, RJ; Hill, RG | 1 |
| Hargreaves, RJ; Hill, RG; Shepheard, SL; Williamson, DJ | 1 |
| Fitzpatrick, JH; Gilboe, DD; Kintner, DB | 1 |
| Dukes, M | 1 |
| Fukuda, S; Makino, H; Ohta, Y | 1 |
| Berend, N; Matheson, MJ; McClean, MA; Rynell, AC | 1 |
| Bac, P; Dupont, C; Evrard, P; Gressens, P; Maurois, P; Pages, N; Stables, JP; Vamecq, J | 1 |
| Fomochkin, II | 1 |
| Brizendine, E; Connolly, P; Durkin, M; Goldberg, J; Kohler, S; Loebenberg, D; Schnizlein-Bick, C; Smedema, M; Wheat, J | 1 |
| Bhat, N; Ghannoum, MA; Okogbule-Wonodi, I; Sanati, H | 1 |
| Egido, J; Gutierrez, S; Herrero-Beaumont, G; Miguélez, R; Palacios, I; Sánchez-Pernaute, O | 1 |
| Ferré, S; Fredholm, BB; Fuxe, K; Lillrank, SM; Lipska, BK; Weinberger, DR | 1 |
| Backer, CL; Crawford, SE; Gonzalez-Crussi, F; Hsueh, W; Huang, L; Liu, H; Mavroudis, C; Mu, Y; Takami, H | 1 |
| Baker, KE; Curtis, MJ | 1 |
| Buster, BL; Linden, J; Scheld, WM; Sullivan, GW | 1 |
| Brodie, A; Gimbel, M; Grigoryev, D; Liu, Y; Long, BJ; Lu, Q | 1 |
| Fothergill, AW; Kirkpatrick, WR; Loebenberg, D; McAtee, RK; Patterson, TF; Rinaldi, MG | 1 |
| Al-Abdely, HM; Bocanegra, R; Fothergill, A; Graybill, JR; Loebenberg, D; Najvar, L; Rinaldi, MG | 1 |
| Chandrasekar, PH; Cutright, J; Manavathu, E | 1 |
| Aktan, B; Gundogdu, C; Karasen, RM; Ozdemir, H; Sutbeyaz, Y | 1 |
| Antonacci, B; Arnold, B; Cacciapuoti, A; Corcoran, E; Halpern, J; Hare, RS; Loebenberg, D; Mendrick, C; Menzel, F; Michalski, M; Miller, GH; Moss, EL; Norris, C; Parmegiani, R; Raynor, K; Yarosh-Tomaine, T | 1 |
| Arzeni, D; Barchiesi, F; Carle, F; Caselli, F; Di Cesare, S; Di Francesco, LF; Fallani, S; Fortuna, M; Giacometti, A; Giannini, D; Mazzei, T; Novelli, A; Scalise, G; Schimizzi, AM | 1 |
| Jain, KK | 1 |
| Andriole, VT; Marino, S; Roberts, J; Schock, K | 1 |
| Cheung, LY; Childs, EW; Miller, JL; Moncure, M; Smalley, DM | 1 |
| Andrade, SP; Cara, DC; Cassali, GD; Coutinho, SF; Poole, SP; Silveira, MR; Souza, DG; Teixeira, MM | 1 |
| Brener, Z; Gref, R; Molina, J; Urbina, J | 1 |
| Costentin, J; Daoust, M; El Yacoubi, M; Ledent, C; Parmentier, M; Vaugeois, J | 1 |
| Avila, N; Bacher, J; Candelario, M; Field-Ridley, A; Groll, AH; Petraitiene, R; Petraitis, V; Piscitelli, S; Sein, T; Walsh, TJ | 1 |
| Barchiesi, F; Bocanegra, R; Carle, F; Caselli, F; Di Cesare, S; Di Francesco, LF; Giacometti, A; Giannini, D; Graybill, JR; Najvar, LK; Scalise, G; Schimizzi, AM | 1 |
| Arika, T; Tatsumi, Y; Yamaguchi, H; Yokoo, M | 1 |
| Beilstein, M; Castagnoli, K; Castagnoli, N; Chen, JF; Petzer, JP; Schwarzschild, MA; Sonsalla, PK; Staal, R; Xu, K; Xu, YH | 1 |
| Atwal, H; Daneshtalab, M; Furukawa, T; Gandhi, A; Higashitani, F; Khan, JK; Micetich, RG; Montaseri, H; Nishida, K; Poglod, M; Saito, H; Salama, SM; Simon, J; Uji, T; Unemi, N | 1 |
| Bertorelli, R; Costentin, J; El Yacoubi, M; Ledent, C; Ongini, E; Parmentier, M; Vaugeois, JM | 1 |
| Hamann, M; Richter, A | 1 |
| Hayashi, R; Ichikawa, T; Iizawa, Y; Itoh, K; Kitamoto, N; Kitazaki, T; Okonogi, K | 1 |
| Fukuoka, T; Harasaki, T; Kamai, Y; Kuwahara, S; Ohya, S; Uchida, K; Yamaguchi, H | 1 |
| Coco, BJ; Kirkpatrick, WR; Patterson, TF; Perea, S | 1 |
| Blasevich, M; Galli, C; Papini, N; Petroni, A | 1 |
| Domenici, MR; Falchi, M; Frank, C; Malchiodi-Albedi, F; Massotti, M; Pèzzola, A; Pintor, A; Popoli, P; Quarta, D; Reggio, R; Scarchilli, L; Tebano, MT | 1 |
| Bocanegra, R; González, GM; Graybill, JR; Loebenberg, D; Najvar, LK; Rinaldi, M; Tijerina, R | 1 |
| MacPhail, RC | 1 |
| Andrade, J; Armstrong, D; Edwards, F; Niki, Y; Schmitt, HJ | 1 |
| Bava, AJ; Negroni, R | 1 |
| Iwahisa, Y; Okamoto, H; Terasawa, M | 1 |
| Anaissie, E; Bodey, G; Gokaslan, A; Griffin, G; Hachem, R; Robinson, R; Rubin, R; Sobel, J | 1 |
| Leong, LL; Stephens, CJ; Sturm, MJ; Taylor, RR | 1 |
| Alison, MR; Antoniw, JW; Garvey, B; Maseri, A; Tippins, JR | 1 |
| Brecht, HM; Helmchen, UM; Oberle, G; Schoeppe, W; Stahl, RA; Thaiss, F; Wenzel, U | 1 |
| Abendschein, DR; Bergmann, SR; Haskel, EJ; Torr, SR; VonVoigtlander, PF | 1 |
| Horie, M; Mase, T; Nagaoka, H; Sakurai, Y; Tomioka, K; Yamada, T | 1 |
| Braquet, P; Friedrich, G; Giessler, J; Hirschelmann, R; Madi, S | 1 |
| Arima, M; Makino, S; Sagara, H; Terashi, Y; Yukawa, T | 1 |
| Ackerbauer, H; Meingassner, JG; Mieth, H; Petranyi, G; Schaude, M | 1 |
| Jonderko, G; Kita, I; Kita, K; Knapek, R; Kotulska, A; Lachowicz, K | 1 |
| Crain, BJ; Nadler, JV; Warner, MA | 1 |
| Hector, RF; Yee, E | 1 |
| Defaveri, J; Graybill, JR | 1 |
| Feuerstein, G; Frerichs, KU; Hallenbeck, JM; Lindsberg, PJ; Yue, TL | 1 |
| Bacher, J; Kelly, P; Lecciones, J; Lee, JW; Peter, J; Pizzo, PA; Thomas, V; Walsh, TJ | 1 |
| Barnes, PJ; Evans, TW; McCormack, DG | 1 |
| Hector, RF; Pappagianis, D; Plempel, M; Theodoropoulos, G; Zimmer, BL | 1 |
| Casals-Stenzel, J; Heuer, H | 1 |
| Abraham, WM; Garrido, R; Stevenson, JS | 1 |
| Ackerbauer, H; Meingassner, JG; Mieth, H | 1 |
| Hopwood, V; Johnson, EM; Kennedy, CT; Smith, KJ; Van Cutsem, J; Vanden Bossche, H; Warnock, DW | 1 |
| Meingassner, JG; Schaude, M | 1 |
| McGregor, S; Ryley, JF; Wilson, RG | 1 |
31 review(s) available for triazoles and Disease Models, Animal
| Article | Year |
|---|---|
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosphate; Adsorption; Adult; Africa, Eastern; Aged; Air Pollutants; Air Pollution; Air Pollution, Indoor; Alcohol Drinking; Allergens; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Anti-Bacterial Agents; Antibodies; Antibodies, Immobilized; Antigen Presentation; Antigens, CD; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Apoptosis; Aptamers, Nucleotide; Asthma; Asthma, Exercise-Induced; Atrophy; Autophagy; Azoospermia; Bacillus cereus; Bacterial Infections; Beclin-1; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Biofouling; Biological Monitoring; Biomarkers; Biomarkers, Tumor; Biosensing Techniques; Blastocyst; Bone Neoplasms; Bone Regeneration; Bronchoconstriction; Burkitt Lymphoma; C9orf72 Protein; Campylobacter; Campylobacter Infections; Campylobacter jejuni; Carcinogenesis; Carcinoma, Hepatocellular; Carcinoma, Pancreatic Ductal; Carcinoma, Squamous Cell; Cardiomyopathies; Caregivers; Carmine; Case-Control Studies; Catalysis; Cattle; Cause of Death; CCAAT-Enhancer-Binding Protein-alpha; CD8-Positive T-Lymphocytes; Cefepime; Cell Differentiation; Cell Line, Tumor; Cell Nucleus; Cell Transdifferentiation; Chelating Agents; Chemical and Drug Induced Liver Injury, Chronic; Chemoradiotherapy, Adjuvant; Child; Child, Preschool; China; Chlorquinaldol; Cholangiocarcinoma; Cholera; Chromatin; Clinical Trials as Topic; Cognitive Dysfunction; Cohort Studies; Colonic Neoplasms; Colorectal Neoplasms; Colorimetry; Cooking; Coordination Complexes; COVID-19; Creatinine; CRISPR-Cas Systems; Critical Care; Critical Illness; Cross-Sectional Studies; Cryopreservation; Cryoprotective Agents; Cysteine; Cytokines; Device Removal; Diet; Diet, High-Fat; Diet, Mediterranean; Dietary Supplements; Dimethyl Sulfoxide; Dipeptides; Disease Models, Animal; Dithiothreitol; DNA; DNA Repeat Expansion; DNA, Bacterial; DNA, Complementary; Dopamine; Electrochemical Techniques; Electrodes; Endocannabinoids; Environmental Exposure; Environmental Monitoring; Environmental Pollutants; Enzyme-Linked Immunosorbent Assay; Erlotinib Hydrochloride; Escherichia coli; Escherichia coli O157; Esophageal Neoplasms; Esophagitis, Peptic; Ethylene Glycol; Europium; Exanthema; Fallopian Tubes; Feces; Female; Fertilization in Vitro; Fluoresceins; Fluorescent Dyes; Follicle Stimulating Hormone; Follow-Up Studies; Food Microbiology; Forced Expiratory Volume; Forkhead Transcription Factors; Frontotemporal Dementia; G-Quadruplexes; Galactose; Gastroenteritis; Gastrointestinal Diseases; Gastrointestinal Microbiome; Gastrointestinal Neoplasms; Gastrointestinal Tract; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genital Neoplasms, Female; Genome-Wide Association Study; Genome, Viral; Genomics; Genotype; Glucose; Glutathione; Glycerol; Gold; Graphite; GTPase-Activating Proteins; Heat-Shock Proteins; Heme Oxygenase-1; Hepacivirus; Hepatitis C; Hepatocytes; Histamine; Histocompatibility Antigens Class II; Hoarseness; Hospice and Palliative Care Nursing; Humans; Hydrogen; Hydrogen Peroxide; Hydrogen Sulfide; Hydroxybenzoates; Hydroxyl Radical; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperthermia, Induced; Hysteroscopy; Immunoassay; Indigo Carmine; Inflammation; Inflammatory Bowel Diseases; Insulin Resistance; Intensive Care Units; Interleukin-11; Interleukin-6; Interleukins; Iodine Radioisotopes; Iran; Iridium; Islets of Langerhans; Kinetics; Lactation; Lactobacillus; Lactobacillus plantarum; Lamins; Latin America; Lead; Lectins; Leukopenia; Ligands; Limit of Detection; Lipopolysaccharides; Lipoprotein Lipase; Liver; Liver Cirrhosis; Liver Neoplasms; Lolium; Luminescent Measurements; Luminol; Lung; Luteinizing Hormone; Macrophages; Magnetic Phenomena; Magnetic Resonance Imaging; Male; Malnutrition; Maltose; Manganese Compounds; Maternal Nutritional Physiological Phenomena; Melatonin; Metabolic Engineering; Metal Nanoparticles; Metallocenes; Metaplasia; Methicillin-Resistant Staphylococcus aureus; Methylation; Mevalonic Acid; Mexico; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microbial Sensitivity Tests; Microbiota; MicroRNAs; Milk; Mitomycin; Molecular Diagnostic Techniques; Molecular Docking Simulation; Monte Carlo Method; Moringa oleifera; Multiple Sclerosis; Muscle Strength; Muscle, Skeletal; Nanocomposites; Nanotubes, Carbon; Neoadjuvant Therapy; Neoplasms; Neurodegenerative Diseases; Neurotransmitter Agents; NF-E2-Related Factor 2; Nickel; Nitrogen Dioxide; Non-alcoholic Fatty Liver Disease; Nucleic Acid Amplification Techniques; Nucleic Acid Hybridization; Nucleocapsid Proteins; Nutritional Status; Obesity; Osteogenesis; Osteosarcoma; Oxidation-Reduction; Oxides; Oxygen; Oxyquinoline; Pain; Palliative Care; Pancreatic Neoplasms; Pandemics; Particulate Matter; Peroxidase; Peroxidases; Phagocytosis; Phaseolus; Photothermal Therapy; Point-of-Care Systems; Polyethyleneimine; Polymers; Polymorphism, Single Nucleotide; Polysomnography; Postoperative Complications; Pregnancy; Pregnant Women; Prenatal Exposure Delayed Effects; Prevalence; Printing, Three-Dimensional; Probability; Probiotics; Prognosis; Prophages; Prospective Studies; Proteomics; Proto-Oncogene Proteins; Pseudomonas aeruginosa; Pseudomonas putida; Pulmonary Disease, Chronic Obstructive; Pulmonary Embolism; Pyridines; Pyrroles; Quality of Life; Quinolones; Rabbits; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Receptors, Histamine; Receptors, Histamine H2; Recombinases; Rectal Neoplasms; Reperfusion Injury; Respiration; Respiratory Function Tests; Respiratory Rate; Respiratory Sounds; Retrospective Studies; rho GTP-Binding Proteins; Risk Assessment; Risk Factors; RNA; RNA, Messenger; RNA, Ribosomal, 16S; Robotic Surgical Procedures; Running; Rural Population; Saccharomyces cerevisiae; Salpingectomy; Sarcopenia; SARS-CoV-2; Seeds; Semen; Sensitivity and Specificity; Sepsis; Shock, Septic; Signal Transduction; Silicon Dioxide; Silver; Sirtuin 1; Skin Neoplasms; Sleep Apnea, Obstructive; Soil; Spain; Spectrum Analysis, Raman; Sperm Retrieval; Spermatozoa; Spirometry; Staphylococcus aureus; STAT3 Transcription Factor; Stereoisomerism; Sterilization, Tubal; Stroke Volume; Sulfadiazine; Sulfites; Superoxide Dismutase; Surface Plasmon Resonance; tau Proteins; Testis; Testosterone; Thioredoxin-Disulfide Reductase; Thyroid Neoplasms; Thyroidectomy; Trans-Activators; Transcription Factor AP-1; Treatment Outcome; Triazoles; Triclosan; Trifluridine; Tumor Microenvironment; Tumor Necrosis Factor-alpha; United States; Uracil; Vagina; Vegetables; Ventricular Function, Left; Ventricular Pressure; Vibrio cholerae; Vietnam; Virulence; Vital Capacity; Vitrification; Walking; Water; Water Pollutants, Radioactive; Whole Genome Sequencing; Wind; YAP-Signaling Proteins; Zeolites; Zinc Oxide | 2023 |
Point of View: Electrophysiological Endpoints Differ When Comparing the Mode of Action of Highly Successful Anti-arrhythmic Drugs in the CAVB Dog Model With TdP.
Topics: Action Potentials; Aniline Compounds; Animals; Anti-Arrhythmia Agents; Atrioventricular Block; Chronic Disease; Disease Models, Animal; Dogs; Electrophysiologic Techniques, Cardiac; Endpoint Determination; Flunarizine; Heart Rate; Phenyl Ethers; Pyridines; Time Factors; Torsades de Pointes; Triazoles; Verapamil | 2019 |
Topics: Acetaminophen; Administration, Oral; Adolescent; Adsorption; Adult; Allyl Compounds; Amylopectin; Amylose; Anaerobiosis; Animals; Anti-Bacterial Agents; Anura; Arginase; Arthritis, Rheumatoid; Asthma; Atmosphere; B-Lymphocytes; Basic Helix-Loop-Helix Transcription Factors; Bioelectric Energy Sources; Biofilms; Biofuels; Biomarkers; Biopolymers; Bioreactors; Brain; Brain Injuries, Traumatic; Breast Neoplasms; Calibration; Carbon Tetrachloride; Caspase 3; Catalysis; Catechin; Cations; Cattle; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Body; Cell Line, Tumor; Cell Plasticity; Chemical and Drug Induced Liver Injury; Chemistry Techniques, Synthetic; China; Chitosan; Chloride Channels; Chromatography, High Pressure Liquid; Chromosome Mapping; Cognition; Cognitive Dysfunction; Cohort Studies; Colitis, Ulcerative; Colloids; Coloring Agents; Congresses as Topic; Correlation of Data; Crystallization; Cyanoacrylates; Cyclohexane Monoterpenes; Cyprinidae; Cytochrome P-450 CYP1A1; Death, Sudden; Dent Disease; Dietary Supplements; Diffusion Magnetic Resonance Imaging; Disease Models, Animal; Disease Progression; Disease Resistance; Disulfides; Drug Monitoring; Drug Stability; Ecotoxicology; Electricity; Electrodes; Endocytosis; Environmental Exposure; Environmental Monitoring; Enzyme Inhibitors; Epithelial-Mesenchymal Transition; Esophageal and Gastric Varices; Esters; Fagopyrum; Female; Ferrosoferric Oxide; Flame Retardants; Flavobacteriaceae; Flow Cytometry; Follow-Up Studies; Formoterol Fumarate; Fusarium; Garlic; Gastrointestinal Hemorrhage; Gene Expression; Genes, Plant; Genetic Markers; Glial Fibrillary Acidic Protein; Gliosis; Global Health; Glutathione Transferase; Glycine max; Gum Arabic; Hemostasis, Endoscopic; Hepatocytes; Hippocampus; Humans; Hydrogen-Ion Concentration; Illinois; Immunoglobulin G; Indoleamine-Pyrrole 2,3,-Dioxygenase; Infant, Newborn; Infant, Small for Gestational Age; Injections, Intraperitoneal; Interleukin-4; Iowa; Iron; Ki-67 Antigen; Kidney; Kinetics; Kynurenine; Lakes; Levofloxacin; Lipid Peroxidation; Lipids; Liver; Liver Cirrhosis, Experimental; Magnetic Fields; Magnetic Iron Oxide Nanoparticles; Male; Manure; Maze Learning; Memory, Short-Term; Metal Nanoparticles; Metals, Heavy; Methane; Mice; Mice, Inbred C57BL; Mice, Knockout; Michigan; Microalgae; Microbial Consortia; Mitochondria; Models, Animal; Models, Chemical; Models, Neurological; Molecular Structure; Molecular Weight; Mutation; Myeloid-Derived Suppressor Cells; NADPH Oxidase 2; Neoplasm Recurrence, Local; Neurites; Neurons; Neuroprotective Agents; NF-kappa B; NIH 3T3 Cells; Nitric Oxide Synthase Type II; Nitrogen; Ohio; Ointments; Ontario; Organelle Biogenesis; Organophosphates; Organophosphorus Compounds; Oxidative Stress; Palladium; Particle Size; Pectins; Phenotype; Phytotherapy; Piperidines; Placenta; Plant Diseases; Plant Extracts; Polymers; Polymorphism, Genetic; Polyphenols; Powders; Pregnancy; Pregnancy Trimester, First; Prospective Studies; Protein Kinase Inhibitors; Protein Structure, Secondary; Proteins; Pyridines; Pyrimidines; Rats, Wistar; Real-Time Polymerase Chain Reaction; Receptors, Aryl Hydrocarbon; Receptors, Chemokine; Receptors, Formyl Peptide; Receptors, Lipoxin; Recovery of Function; Recurrence; Reference Standards; Reference Values; Reproducibility of Results; Respiratory Function Tests; Retrospective Studies; Risk; Sensitivity and Specificity; Sewage; Signal Transduction; Sodium Glutamate; Soil; Solanum tuberosum; Solubility; Solutions; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis; Spermatozoa; STAT3 Transcription Factor; Sulfamethoxazole; Tea; Temperature; Thermodynamics; Thrombin; Treatment Outcome; Triazoles; United States; Viscosity; Waste Disposal, Fluid; Wastewater; Water; Water Pollutants, Chemical; Water Purification; White Matter; Wisconsin; X-Ray Diffraction; Zea mays | 2013 |
RIPK1: A rising star in inflammatory and neoplastic skin diseases.
Topics: Animals; Clinical Trials, Phase II as Topic; Dermatitis; Disease Models, Animal; Drug Evaluation, Preclinical; Half-Life; Humans; Imidazoles; Indoles; Mice; Mice, Knockout; Necroptosis; Oxazepines; Protein Kinase Inhibitors; Rats; Receptor-Interacting Protein Serine-Threonine Kinases; Signal Transduction; Skin; Skin Neoplasms; Treatment Outcome; Triazoles; Tumor-Associated Macrophages; Ubiquitination | 2020 |
Animal Models for Studying Triazole Resistance in Aspergillus fumigatus.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Disease Models, Animal; Drug Resistance, Multiple, Fungal; Echinocandins; Humans; Mice; Microbial Sensitivity Tests; Triazoles | 2017 |
Regulated necrosis in kidney ischemia-reperfusion injury.
Topics: Acute Kidney Injury; Animals; Apoptosis; Clinical Trials, Phase II as Topic; Disease Models, Animal; Epithelial Cells; Ferroptosis; Humans; Kidney Failure, Chronic; Kidney Transplantation; Kidney Tubules; Mice; Mice, Transgenic; Microvessels; Necroptosis; Necrosis; Oxazepines; Protein Kinase Inhibitors; Protein Kinases; Randomized Controlled Trials as Topic; Receptor-Interacting Protein Serine-Threonine Kinases; Regional Blood Flow; Reperfusion Injury; Signal Transduction; Treatment Outcome; Triazoles | 2019 |
[Orexin: clinical and therapeutic implications].
Topics: Animals; Arousal; Azepines; Benzoxazoles; Disease Models, Animal; Drug Evaluation, Preclinical; Feeding and Eating Disorders; Feeding Behavior; Humans; Intracellular Signaling Peptides and Proteins; Mice; Mice, Knockout; Mice, Transgenic; Motor Activity; Naphthyridines; Narcolepsy; Neuropeptides; Obesity; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Sleep Disorders, Circadian Rhythm; Sleep Disorders, Intrinsic; Substance-Related Disorders; Triazoles; Urea | 2014 |
[Progress in combination therapy for invasive aspergillosis].
Topics: Amphotericin B; Animals; Antifungal Agents; Aspergillosis; Aspergillus; Clinical Trials as Topic; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Echinocandins; Humans; Immunosuppression Therapy; Survival Rate; Triazoles | 2014 |
Antifungal pharmacokinetics and pharmacodynamics.
Topics: Animals; Antifungal Agents; Disease Models, Animal; Echinocandins; Flucytosine; Humans; Mice; Mycoses; Polyenes; Rabbits; Rats; Triazoles | 2014 |
The use of posaconazole against Chagas disease.
Topics: Animals; Chagas Disease; Disease Models, Animal; Humans; Mice; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients.
Topics: Anemia; Animals; Barbiturates; Blood Pressure; Disease Models, Animal; Drug Design; Drug Interactions; Glycine; Hepcidins; Humans; Hypoxia-Inducible Factor 1; Inflammation; Isoquinolines; Kidney Failure, Chronic; Picolinic Acids; Protein Domains; Pyrazoles; Triazoles | 2017 |
Dipeptidyl peptidase IV (DPP IV) and related molecules in type 2 diabetes.
Topics: Adamantane; Animals; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Humans; Hypoglycemic Agents; Incretins; Nitriles; Pyrazines; Pyrrolidines; Sitagliptin Phosphate; Triazoles; Vildagliptin | 2008 |
Isavuconazole: a new and promising antifungal triazole for the treatment of invasive fungal infections.
Topics: Animals; Antifungal Agents; Aspergillus; Candida; Clinical Trials as Topic; Cryptococcus neoformans; Disease Models, Animal; Mycoses; Nitriles; Pyridines; Triazoles | 2008 |
Posaconazole's impact on prophylaxis and treatment of invasive fungal infections: an update.
Topics: Animals; Antifungal Agents; Disease Models, Animal; Drug Dosage Calculations; Drug Interactions; Drug Resistance, Fungal; Humans; Microbial Sensitivity Tests; Mycoses; Triazoles | 2009 |
Novel investigational adenosine A2A receptor antagonists for Parkinson's disease.
Topics: Adenine; Adenosine A2 Receptor Antagonists; Animals; Antiparkinson Agents; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Disease Models, Animal; Humans; Parkinson Disease; Pyrimidines; Triazoles | 2009 |
Isavuconazole: a comprehensive review of spectrum of activity of a new triazole.
Topics: Animals; Antifungal Agents; Clinical Trials as Topic; Disease Models, Animal; Fungi; Humans; Mice; Microbial Sensitivity Tests; Mycoses; Nitriles; Pyridines; Triazoles | 2010 |
Clinical use of CCR5 inhibitors in HIV and beyond.
Topics: Animals; Antiviral Agents; CCR5 Receptor Antagonists; Clinical Trials as Topic; Cyclohexanes; Disease Models, Animal; Encephalitis, Tick-Borne; Female; HIV Infections; HIV-1; Humans; Male; Maraviroc; Protein Binding; Triazoles; West Nile Fever | 2011 |
The emerging use of aromatase inhibitors for endometriosis treatment.
Topics: Anastrozole; Animals; Aromatase Inhibitors; Disease Models, Animal; Endometriosis; Endometrium; Estrogens; Female; Fertility; Humans; Letrozole; Mice; Nitriles; Ovary; Pelvic Pain; Rats; Triazoles | 2011 |
Posaconazole for the treatment of mucormycosis.
Topics: Animals; Antifungal Agents; Disease Models, Animal; Female; Humans; Male; Mice; Microbial Sensitivity Tests; Mucorales; Mucormycosis; Treatment Outcome; Triazoles | 2011 |
Pharmacokinetics and pharmacodynamics in the development of antifungal compounds.
Topics: Animals; Antifungal Agents; Area Under Curve; Clinical Trials as Topic; Disease Models, Animal; Drug Design; Fungi; Humans; Microbial Sensitivity Tests; Mycoses; Triazoles | 2003 |
Combination antifungal therapy: where are we now, and where are we going?
Topics: Amphotericin B; Animals; Antifungal Agents; Aspergillosis; Azoles; Candidiasis; Caspofungin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Echinocandins; Fluconazole; Humans; In Vitro Techniques; Lipopeptides; Lipoproteins; Micafungin; Mycoses; Peptides, Cyclic; Pyrimidines; Randomized Controlled Trials as Topic; Time Factors; Treatment Outcome; Triazoles; Voriconazole | 2004 |
Therapeutic observations in MCF-7 aromatase xenografts.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aromatase; Aromatase Inhibitors; Disease Models, Animal; Estradiol; Estrogen Antagonists; Female; Fulvestrant; Humans; Letrozole; Mammary Neoplasms, Experimental; Mice; Nitriles; Receptors, Estrogen; Triazoles; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2005 |
Voriconazole: review of a broad spectrum triazole antifungal agent.
Topics: Administration, Oral; Animals; Antifungal Agents; Aspergillosis; Candidiasis; Caspofungin; Cryptococcosis; Cyclic N-Oxides; Disease Models, Animal; Drug Resistance, Fungal; Drug Therapy, Combination; Echinocandins; Fluconazole; Humans; Injections, Intravenous; Lipopeptides; Microbial Sensitivity Tests; Mycoses; Peptides, Cyclic; Pyrimidines; Randomized Controlled Trials as Topic; Triazoles; Voriconazole | 2005 |
[Interactions between radiation and hormonal therapy in breast cancer: simultaneous or sequential treatment].
Topics: Animals; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Disease Models, Animal; Drug Administration Schedule; Female; Humans; Letrozole; Nitriles; Radiation-Sensitizing Agents; Radiotherapy, Adjuvant; Randomized Controlled Trials as Topic; Selective Estrogen Receptor Modulators; Tamoxifen; Triazoles | 2006 |
Antifungal efficacy and pharmacodynamics of posaconazole in experimental models of invasive fungal infections.
Topics: Animals; Antifungal Agents; Aspergillosis; Candidiasis; Disease Models, Animal; Humans; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Mycoses; Rabbits; Rats; Treatment Outcome; Triazoles | 2006 |
[A new aspect in the research on antiepileptic drugs].
Topics: Acetamides; Amines; Animals; Anticonvulsants; Benzodiazepines; Carbamates; Cyclohexanecarboxylic Acids; Disease Models, Animal; Drug Design; Gabapentin; gamma-Aminobutyric Acid; Humans; Lacosamide; Levetiracetam; Phenylenediamines; Piracetam; Pregabalin; Pregnanolone; Pyrrolidinones; Triazoles | 2007 |
Posaconazole: a new broad-spectrum antifungal agent.
Topics: Animals; Antifungal Agents; Disease Models, Animal; Drug Resistance, Fungal; Fungi; Humans; Immunocompromised Host; Microbial Sensitivity Tests; Mycoses; Salvage Therapy; Triazoles | 2007 |
Reviews of anti-infective agents: posaconazole: a broad-spectrum triazole antifungal agent.
Topics: Animals; Antifungal Agents; Candidiasis; Controlled Clinical Trials as Topic; Disease Models, Animal; Fungi; Humans; Microbial Sensitivity Tests; Mycoses; Triazoles | 2007 |
The relevance of preclinical models to the treatment of postmenopausal breast cancer.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Anastrozole; Animals; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Disease Models, Animal; Enzyme Inhibitors; Female; Humans; Mammary Neoplasms, Experimental; Nitriles; Postmenopause; Rats; Triazoles | 1997 |
An assessment of rufinamide as an anti-epileptic in comparison with other drugs in clinical development.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Humans; Triazoles | 2000 |
Episodic exposures to chemicals: what relevance to chemical intolerance?
Topics: Adolescent; Adult; Aged; Animals; Carbaryl; Child; Child, Preschool; Disease Models, Animal; Disease Susceptibility; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Administration Schedule; Drug Resistance; Environmental Pollutants; Female; Fungicides, Industrial; Genetic Variation; Humans; Infant; Infant, Newborn; Insecticides; Male; Mice; Middle Aged; Motor Activity; Multiple Chemical Sensitivity; Rats; Reference Standards; Research Design; Risk Assessment; Solvents; Toxicology; Triazoles; Xenobiotics | 2001 |
7 trial(s) available for triazoles and Disease Models, Animal
| Article | Year |
|---|---|
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosphate; Adsorption; Adult; Africa, Eastern; Aged; Air Pollutants; Air Pollution; Air Pollution, Indoor; Alcohol Drinking; Allergens; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Anti-Bacterial Agents; Antibodies; Antibodies, Immobilized; Antigen Presentation; Antigens, CD; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Apoptosis; Aptamers, Nucleotide; Asthma; Asthma, Exercise-Induced; Atrophy; Autophagy; Azoospermia; Bacillus cereus; Bacterial Infections; Beclin-1; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Biofouling; Biological Monitoring; Biomarkers; Biomarkers, Tumor; Biosensing Techniques; Blastocyst; Bone Neoplasms; Bone Regeneration; Bronchoconstriction; Burkitt Lymphoma; C9orf72 Protein; Campylobacter; Campylobacter Infections; Campylobacter jejuni; Carcinogenesis; Carcinoma, Hepatocellular; Carcinoma, Pancreatic Ductal; Carcinoma, Squamous Cell; Cardiomyopathies; Caregivers; Carmine; Case-Control Studies; Catalysis; Cattle; Cause of Death; CCAAT-Enhancer-Binding Protein-alpha; CD8-Positive T-Lymphocytes; Cefepime; Cell Differentiation; Cell Line, Tumor; Cell Nucleus; Cell Transdifferentiation; Chelating Agents; Chemical and Drug Induced Liver Injury, Chronic; Chemoradiotherapy, Adjuvant; Child; Child, Preschool; China; Chlorquinaldol; Cholangiocarcinoma; Cholera; Chromatin; Clinical Trials as Topic; Cognitive Dysfunction; Cohort Studies; Colonic Neoplasms; Colorectal Neoplasms; Colorimetry; Cooking; Coordination Complexes; COVID-19; Creatinine; CRISPR-Cas Systems; Critical Care; Critical Illness; Cross-Sectional Studies; Cryopreservation; Cryoprotective Agents; Cysteine; Cytokines; Device Removal; Diet; Diet, High-Fat; Diet, Mediterranean; Dietary Supplements; Dimethyl Sulfoxide; Dipeptides; Disease Models, Animal; Dithiothreitol; DNA; DNA Repeat Expansion; DNA, Bacterial; DNA, Complementary; Dopamine; Electrochemical Techniques; Electrodes; Endocannabinoids; Environmental Exposure; Environmental Monitoring; Environmental Pollutants; Enzyme-Linked Immunosorbent Assay; Erlotinib Hydrochloride; Escherichia coli; Escherichia coli O157; Esophageal Neoplasms; Esophagitis, Peptic; Ethylene Glycol; Europium; Exanthema; Fallopian Tubes; Feces; Female; Fertilization in Vitro; Fluoresceins; Fluorescent Dyes; Follicle Stimulating Hormone; Follow-Up Studies; Food Microbiology; Forced Expiratory Volume; Forkhead Transcription Factors; Frontotemporal Dementia; G-Quadruplexes; Galactose; Gastroenteritis; Gastrointestinal Diseases; Gastrointestinal Microbiome; Gastrointestinal Neoplasms; Gastrointestinal Tract; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genital Neoplasms, Female; Genome-Wide Association Study; Genome, Viral; Genomics; Genotype; Glucose; Glutathione; Glycerol; Gold; Graphite; GTPase-Activating Proteins; Heat-Shock Proteins; Heme Oxygenase-1; Hepacivirus; Hepatitis C; Hepatocytes; Histamine; Histocompatibility Antigens Class II; Hoarseness; Hospice and Palliative Care Nursing; Humans; Hydrogen; Hydrogen Peroxide; Hydrogen Sulfide; Hydroxybenzoates; Hydroxyl Radical; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperthermia, Induced; Hysteroscopy; Immunoassay; Indigo Carmine; Inflammation; Inflammatory Bowel Diseases; Insulin Resistance; Intensive Care Units; Interleukin-11; Interleukin-6; Interleukins; Iodine Radioisotopes; Iran; Iridium; Islets of Langerhans; Kinetics; Lactation; Lactobacillus; Lactobacillus plantarum; Lamins; Latin America; Lead; Lectins; Leukopenia; Ligands; Limit of Detection; Lipopolysaccharides; Lipoprotein Lipase; Liver; Liver Cirrhosis; Liver Neoplasms; Lolium; Luminescent Measurements; Luminol; Lung; Luteinizing Hormone; Macrophages; Magnetic Phenomena; Magnetic Resonance Imaging; Male; Malnutrition; Maltose; Manganese Compounds; Maternal Nutritional Physiological Phenomena; Melatonin; Metabolic Engineering; Metal Nanoparticles; Metallocenes; Metaplasia; Methicillin-Resistant Staphylococcus aureus; Methylation; Mevalonic Acid; Mexico; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microbial Sensitivity Tests; Microbiota; MicroRNAs; Milk; Mitomycin; Molecular Diagnostic Techniques; Molecular Docking Simulation; Monte Carlo Method; Moringa oleifera; Multiple Sclerosis; Muscle Strength; Muscle, Skeletal; Nanocomposites; Nanotubes, Carbon; Neoadjuvant Therapy; Neoplasms; Neurodegenerative Diseases; Neurotransmitter Agents; NF-E2-Related Factor 2; Nickel; Nitrogen Dioxide; Non-alcoholic Fatty Liver Disease; Nucleic Acid Amplification Techniques; Nucleic Acid Hybridization; Nucleocapsid Proteins; Nutritional Status; Obesity; Osteogenesis; Osteosarcoma; Oxidation-Reduction; Oxides; Oxygen; Oxyquinoline; Pain; Palliative Care; Pancreatic Neoplasms; Pandemics; Particulate Matter; Peroxidase; Peroxidases; Phagocytosis; Phaseolus; Photothermal Therapy; Point-of-Care Systems; Polyethyleneimine; Polymers; Polymorphism, Single Nucleotide; Polysomnography; Postoperative Complications; Pregnancy; Pregnant Women; Prenatal Exposure Delayed Effects; Prevalence; Printing, Three-Dimensional; Probability; Probiotics; Prognosis; Prophages; Prospective Studies; Proteomics; Proto-Oncogene Proteins; Pseudomonas aeruginosa; Pseudomonas putida; Pulmonary Disease, Chronic Obstructive; Pulmonary Embolism; Pyridines; Pyrroles; Quality of Life; Quinolones; Rabbits; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Receptors, Histamine; Receptors, Histamine H2; Recombinases; Rectal Neoplasms; Reperfusion Injury; Respiration; Respiratory Function Tests; Respiratory Rate; Respiratory Sounds; Retrospective Studies; rho GTP-Binding Proteins; Risk Assessment; Risk Factors; RNA; RNA, Messenger; RNA, Ribosomal, 16S; Robotic Surgical Procedures; Running; Rural Population; Saccharomyces cerevisiae; Salpingectomy; Sarcopenia; SARS-CoV-2; Seeds; Semen; Sensitivity and Specificity; Sepsis; Shock, Septic; Signal Transduction; Silicon Dioxide; Silver; Sirtuin 1; Skin Neoplasms; Sleep Apnea, Obstructive; Soil; Spain; Spectrum Analysis, Raman; Sperm Retrieval; Spermatozoa; Spirometry; Staphylococcus aureus; STAT3 Transcription Factor; Stereoisomerism; Sterilization, Tubal; Stroke Volume; Sulfadiazine; Sulfites; Superoxide Dismutase; Surface Plasmon Resonance; tau Proteins; Testis; Testosterone; Thioredoxin-Disulfide Reductase; Thyroid Neoplasms; Thyroidectomy; Trans-Activators; Transcription Factor AP-1; Treatment Outcome; Triazoles; Triclosan; Trifluridine; Tumor Microenvironment; Tumor Necrosis Factor-alpha; United States; Uracil; Vagina; Vegetables; Ventricular Function, Left; Ventricular Pressure; Vibrio cholerae; Vietnam; Virulence; Vital Capacity; Vitrification; Walking; Water; Water Pollutants, Radioactive; Whole Genome Sequencing; Wind; YAP-Signaling Proteins; Zeolites; Zinc Oxide | 2023 |
Topics: Acetaminophen; Administration, Oral; Adolescent; Adsorption; Adult; Allyl Compounds; Amylopectin; Amylose; Anaerobiosis; Animals; Anti-Bacterial Agents; Anura; Arginase; Arthritis, Rheumatoid; Asthma; Atmosphere; B-Lymphocytes; Basic Helix-Loop-Helix Transcription Factors; Bioelectric Energy Sources; Biofilms; Biofuels; Biomarkers; Biopolymers; Bioreactors; Brain; Brain Injuries, Traumatic; Breast Neoplasms; Calibration; Carbon Tetrachloride; Caspase 3; Catalysis; Catechin; Cations; Cattle; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Body; Cell Line, Tumor; Cell Plasticity; Chemical and Drug Induced Liver Injury; Chemistry Techniques, Synthetic; China; Chitosan; Chloride Channels; Chromatography, High Pressure Liquid; Chromosome Mapping; Cognition; Cognitive Dysfunction; Cohort Studies; Colitis, Ulcerative; Colloids; Coloring Agents; Congresses as Topic; Correlation of Data; Crystallization; Cyanoacrylates; Cyclohexane Monoterpenes; Cyprinidae; Cytochrome P-450 CYP1A1; Death, Sudden; Dent Disease; Dietary Supplements; Diffusion Magnetic Resonance Imaging; Disease Models, Animal; Disease Progression; Disease Resistance; Disulfides; Drug Monitoring; Drug Stability; Ecotoxicology; Electricity; Electrodes; Endocytosis; Environmental Exposure; Environmental Monitoring; Enzyme Inhibitors; Epithelial-Mesenchymal Transition; Esophageal and Gastric Varices; Esters; Fagopyrum; Female; Ferrosoferric Oxide; Flame Retardants; Flavobacteriaceae; Flow Cytometry; Follow-Up Studies; Formoterol Fumarate; Fusarium; Garlic; Gastrointestinal Hemorrhage; Gene Expression; Genes, Plant; Genetic Markers; Glial Fibrillary Acidic Protein; Gliosis; Global Health; Glutathione Transferase; Glycine max; Gum Arabic; Hemostasis, Endoscopic; Hepatocytes; Hippocampus; Humans; Hydrogen-Ion Concentration; Illinois; Immunoglobulin G; Indoleamine-Pyrrole 2,3,-Dioxygenase; Infant, Newborn; Infant, Small for Gestational Age; Injections, Intraperitoneal; Interleukin-4; Iowa; Iron; Ki-67 Antigen; Kidney; Kinetics; Kynurenine; Lakes; Levofloxacin; Lipid Peroxidation; Lipids; Liver; Liver Cirrhosis, Experimental; Magnetic Fields; Magnetic Iron Oxide Nanoparticles; Male; Manure; Maze Learning; Memory, Short-Term; Metal Nanoparticles; Metals, Heavy; Methane; Mice; Mice, Inbred C57BL; Mice, Knockout; Michigan; Microalgae; Microbial Consortia; Mitochondria; Models, Animal; Models, Chemical; Models, Neurological; Molecular Structure; Molecular Weight; Mutation; Myeloid-Derived Suppressor Cells; NADPH Oxidase 2; Neoplasm Recurrence, Local; Neurites; Neurons; Neuroprotective Agents; NF-kappa B; NIH 3T3 Cells; Nitric Oxide Synthase Type II; Nitrogen; Ohio; Ointments; Ontario; Organelle Biogenesis; Organophosphates; Organophosphorus Compounds; Oxidative Stress; Palladium; Particle Size; Pectins; Phenotype; Phytotherapy; Piperidines; Placenta; Plant Diseases; Plant Extracts; Polymers; Polymorphism, Genetic; Polyphenols; Powders; Pregnancy; Pregnancy Trimester, First; Prospective Studies; Protein Kinase Inhibitors; Protein Structure, Secondary; Proteins; Pyridines; Pyrimidines; Rats, Wistar; Real-Time Polymerase Chain Reaction; Receptors, Aryl Hydrocarbon; Receptors, Chemokine; Receptors, Formyl Peptide; Receptors, Lipoxin; Recovery of Function; Recurrence; Reference Standards; Reference Values; Reproducibility of Results; Respiratory Function Tests; Retrospective Studies; Risk; Sensitivity and Specificity; Sewage; Signal Transduction; Sodium Glutamate; Soil; Solanum tuberosum; Solubility; Solutions; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis; Spermatozoa; STAT3 Transcription Factor; Sulfamethoxazole; Tea; Temperature; Thermodynamics; Thrombin; Treatment Outcome; Triazoles; United States; Viscosity; Waste Disposal, Fluid; Wastewater; Water; Water Pollutants, Chemical; Water Purification; White Matter; Wisconsin; X-Ray Diffraction; Zea mays | 2013 |
Consecutive Day HSP90 Inhibitor Administration Improves Efficacy in Murine Models of KIT-Driven Malignancies and Canine Mast Cell Tumors.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Disease Models, Animal; Dogs; HSP90 Heat-Shock Proteins; Leukemia, Mast-Cell; Mice; Oncogenes; Proteolysis; Proto-Oncogene Proteins c-kit; Treatment Outcome; Triazoles; Xenograft Model Antitumor Assays | 2018 |
Plasma glutamate-modulated interaction of A2AR and mGluR5 on BMDCs aggravates traumatic brain injury-induced acute lung injury.
Topics: Acute Lung Injury; Adenosine; Adenosine A2 Receptor Agonists; Adult; Animals; Bone Marrow Cells; Brain Injuries; Disease Models, Animal; Female; Glutamic Acid; Humans; Male; Mice; Mice, Knockout; Middle Aged; Phenethylamines; Protein Kinase C; Receptor, Adenosine A2A; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Signal Transduction; Triazines; Triazoles; Type C Phospholipases | 2013 |
Pharmacodynamics of isavuconazole in experimental invasive pulmonary aspergillosis: implications for clinical breakpoints.
Topics: Animals; Antifungal Agents; Aspergillus; Disease Models, Animal; Drug Monitoring; Female; Galactose; Humans; Invasive Pulmonary Aspergillosis; Mannans; Microbial Sensitivity Tests; Models, Theoretical; Monte Carlo Method; Nitriles; Pyridines; Rabbits; Triazoles | 2016 |
Biomarker-guided clinical development of the first-in-class anti-inflammatory FPR2/ALX agonist ACT-389949.
Topics: Adolescent; Adult; Animals; Biomarkers; Cell Migration Assays; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Inflammation; Lipopolysaccharides; Male; Middle Aged; Neutrophils; Oxazoles; Receptors, Formyl Peptide; Receptors, Lipoxin; Triazoles; Young Adult | 2017 |
Impairment of adenosine A3 receptor activity disrupts neutrophil migratory capacity and impacts innate immune function in vivo.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Animals; Chemotaxis; Colitis; Dextran Sulfate; Disease Models, Animal; Humans; Immunity, Innate; Inflammation; Mice; Mice, Knockout; Neutrophils; Quinazolines; Receptor, Adenosine A3; Triazoles; Up-Regulation | 2012 |
672 other study(ies) available for triazoles and Disease Models, Animal
| Article | Year |
|---|---|
Tadalafil enhances the therapeutic efficacy of BET inhibitors in hepatocellular carcinoma through activating Hippo pathway.
Topics: Animals; Azepines; Carcinoma, Hepatocellular; Cyclic Nucleotide Phosphodiesterases, Type 5; Disease Models, Animal; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression Regulation, Neoplastic; Hippo Signaling Pathway; Humans; Liver Neoplasms; Mice; Nerve Tissue Proteins; Phosphodiesterase 5 Inhibitors; Proto-Oncogene Proteins c-myc; Receptors, Cell Surface; Tadalafil; Triazoles; YAP-Signaling Proteins | 2021 |
Brd4 Regulates the Homeostasis of CD8
Topics: Adoptive Transfer; Animals; Antigens, Viral; Azepines; CD8-Positive T-Lymphocytes; Cell Proliferation; Chlorocebus aethiops; Disease Models, Animal; Glucose Transporter Type 1; Glycolysis; Host-Pathogen Interactions; Lymphocyte Activation; Lymphocytic Choriomeningitis; Lymphocytic choriomeningitis virus; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Nuclear Proteins; Proto-Oncogene Proteins c-myc; Transcription Factors; Triazoles; Vero Cells | 2021 |
Rational Combination of CRM1 Inhibitor Selinexor and Olaparib Shows Synergy in Ovarian Cancer Cell Lines and Mouse Models.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Disease Models, Animal; Female; High-Throughput Screening Assays; Humans; Hydrazines; Mice; Mice, Nude; Ovarian Neoplasms; Phthalazines; Piperazines; Triazoles | 2021 |
Inosine monophosphate and inosine differentially regulate endotoxemia and bacterial sepsis.
Topics: Adenosine A2 Receptor Antagonists; Adenosine A3 Receptor Antagonists; Animals; Disease Models, Animal; Endotoxemia; Inosine; Inosine Monophosphate; Interleukin-10; Male; Mice; Mice, Inbred C57BL; Pneumonia, Pneumococcal; Quinazolines; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Receptor, Adenosine A3; Signal Transduction; Streptococcus pneumoniae; Triazoles; Tumor Necrosis Factor-alpha | 2021 |
JQ-1 ameliorates schistosomiasis liver fibrosis by suppressing JAK2 and STAT3 activation.
Topics: Animals; Antifibrotic Agents; Azepines; Cell Line; Cell Proliferation; Disease Models, Animal; Female; Hepatic Stellate Cells; Host-Pathogen Interactions; Janus Kinase 2; Liver; Liver Cirrhosis; Mice, Inbred C57BL; Phosphorylation; Schistosoma japonicum; Schistosomiasis; Signal Transduction; STAT3 Transcription Factor; Triazoles | 2021 |
Selective Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibition by the SCH772984 Compound Attenuates In Vitro and In Vivo Inflammatory Responses and Prolongs Survival in Murine Sepsis Models.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Chemokine CCL2; Disease Models, Animal; Down-Regulation; Drug Repositioning; Endotoxemia; Gene Expression Regulation; Indazoles; Lipopolysaccharides; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 3; Piperazines; Platelet Activation; Pyridines; Pyrrolidines; RAW 264.7 Cells; Transcriptome; Triazoles; Tumor Necrosis Factor-alpha | 2021 |
BET protein inhibition evidently enhances sensitivity to PI3K/mTOR dual inhibition in intrahepatic cholangiocarcinoma.
Topics: Animals; Antineoplastic Agents; Azepines; Bile Duct Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cholangiocarcinoma; Disease Models, Animal; Drug Therapy, Combination; Humans; Imidazoles; Mice; MTOR Inhibitors; Nerve Tissue Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinolines; Receptors, Cell Surface; Signal Transduction; TOR Serine-Threonine Kinases; Transcriptome; Treatment Outcome; Triazoles | 2021 |
A common fungicide tebuconazole promotes colitis in mice via regulating gut microbiota.
Topics: Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Fungicides, Industrial; Gastrointestinal Microbiome; Mice; Mice, Inbred C57BL; Triazoles | 2022 |
Adenosine Receptors Modulate the Exogenous Ketogenic Supplement-Evoked Alleviating Effect on Lipopolysaccharide-Generated Increase in Absence Epileptic Activity in WAG/Rij Rats.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Body Weight; Dietary Supplements; Disease Models, Animal; Epilepsy, Absence; Injections, Intraperitoneal; Ketones; Ketosis; Lipopolysaccharides; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, Wistar; Receptors, Purinergic P1; Triazoles; Xanthines | 2021 |
AXL targeting by a specific small molecule or monoclonal antibody inhibits renal cell carcinoma progression in an orthotopic mice model.
Topics: Animals; Axl Receptor Tyrosine Kinase; Benzocycloheptenes; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Disease Progression; Humans; Kidney Neoplasms; Mice; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor Protein-Tyrosine Kinases; Signal Transduction; Triazoles | 2021 |
Simultaneous administration of bromodomain and histone deacetylase I inhibitors alleviates cognition deficit in Alzheimer's model of rats.
Topics: Alzheimer Disease; Animals; Azepines; Behavior, Animal; Benzamides; CREB-Binding Protein; Disease Models, Animal; Drug Therapy, Combination; Epigenesis, Genetic; Histone Deacetylase Inhibitors; Male; Memory Disorders; Nuclear Proteins; Pyridines; Random Allocation; Rats; Rats, Wistar; Transcription Factors; Triazoles; Tumor Necrosis Factor-alpha | 2022 |
Differential sleep/wake response and sex differences following acute suvorexant, MK-1064 and zolpidem administration in the rTg4510 mouse model of tauopathy.
Topics: Animals; Azepines; Disease Models, Animal; Female; Hypnotics and Sedatives; Male; Mice; Mice, Transgenic; Sex Characteristics; Sleep; Sleep Wake Disorders; Tauopathies; Triazoles; Zolpidem | 2022 |
BRD4 Inhibition Attenuates Inflammatory Pain by Ameliorating NLRP3 Inflammasome-Induced Pyroptosis.
Topics: Animals; Azepines; Cell Line; Disease Models, Animal; Freund's Adjuvant; Hyperalgesia; Inflammasomes; Inflammation; Injections, Spinal; Male; Mice; Mice, Inbred C57BL; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Nuclear Proteins; Pain; Pyroptosis; Signal Transduction; Transcription Factors; Triazoles | 2022 |
A novel therapeutic combination of sitagliptin and melatonin regenerates pancreatic β-cells in mouse and human islets.
Topics: Animals; Blood Glucose; Diabetes Mellitus; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Humans; Hypoglycemic Agents; Melatonin; Mice; Pyrazines; Sitagliptin Phosphate; Triazoles | 2022 |
FASN inhibition targets multiple drivers of NASH by reducing steatosis, inflammation and fibrosis in preclinical models.
Topics: Actins; Animals; Carcinoma, Hepatocellular; Cytokines; Disease Models, Animal; Fatty Acid Synthase, Type I; Fatty Acid Synthases; Humans; Inflammation; Lipopolysaccharides; Liver Cirrhosis; Liver Neoplasms; Mice; Nitriles; Non-alcoholic Fatty Liver Disease; Piperidines; Triazoles; Triglycerides | 2022 |
QTC-4-MeOBnE Ameliorated Depressive-Like Behavior and Memory Impairment in 3xTg Mice.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Depressive Disorder, Major; Disease Models, Animal; Hippocampus; Memory Disorders; Mice; Mice, Transgenic; Neuroinflammatory Diseases; tau Proteins; Triazoles | 2023 |
Inhibition of JAK1 mitigates postoperative ileus in mice.
Topics: Animals; Disease Models, Animal; Gastrointestinal Motility; Humans; Ileus; Inflammation Mediators; Intestinal Mucosa; Janus Kinase 1; Jejunum; Male; Mice; Muscle Contraction; Muscle, Smooth; Peroxidase; Postoperative Complications; Preoperative Care; Pyridines; Signal Transduction; Triazoles; Up-Regulation | 2019 |
Synthesis, activity, and molecular modeling studies of 1,2,3-triazole derivatives from natural phenylpropanoids as new trypanocidal agents.
Topics: Animals; Biological Products; Chagas Disease; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Disease Models, Animal; Drug Design; Humans; Mice; Molecular Docking Simulation; Molecular Structure; Protozoan Proteins; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Inhibition of the thyroid hormonogenic H
Topics: Animals; Benzoxazoles; Disease Models, Animal; Dual Oxidases; Gene Expression Regulation; Gene Regulatory Networks; Goiter; Hydrogen Peroxide; Mutation; NADPH Oxidases; Thyroid Hormones; Triazoles; Zebrafish; Zebrafish Proteins | 2020 |
A Functional Role of GAS6/TAM in Nonalcoholic Steatohepatitis Progression Implicates AXL as Therapeutic Target.
Topics: Adult; Aged; Animals; Axl Receptor Tyrosine Kinase; Benzocycloheptenes; Biomarkers; Biopsy; c-Mer Tyrosine Kinase; Cells, Cultured; Disease Models, Animal; Disease Progression; Female; Hepatic Stellate Cells; Hepatocytes; Humans; Intercellular Signaling Peptides and Proteins; Kupffer Cells; Liver; Liver Cirrhosis; Male; Mice; Mice, Knockout; Middle Aged; Non-alcoholic Fatty Liver Disease; Primary Cell Culture; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor Protein-Tyrosine Kinases; Signal Transduction; STAT3 Transcription Factor; Triazoles | 2020 |
Treatment with JQ1, a BET bromodomain inhibitor, is selectively detrimental to R6/2 Huntington's disease mice.
Topics: Acetylation; Animals; Azepines; Behavior Rating Scale; Behavioral Symptoms; Cerebral Cortex; Chromatin Immunoprecipitation Sequencing; Corpus Striatum; Disease Models, Animal; Energy Metabolism; Epigenesis, Genetic; Gene Expression Regulation; Gene Ontology; Histones; Huntingtin Protein; Huntington Disease; Male; Mice; Mice, Transgenic; Motor Activity; Protein Biosynthesis; RNA-Seq; Signal Transduction; Triazoles | 2020 |
Preparation and
Topics: Administration, Topical; Animals; Antifungal Agents; Disease Models, Animal; Guinea Pigs; Humans; In Vitro Techniques; Male; Membranes, Artificial; Nails; Onychomycosis; Permeability; Skin; Skin Absorption; Tinea; Triazoles; Trichophyton | 2019 |
In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model.
Topics: Animals; Dihydroorotate Dehydrogenase; Disease Models, Animal; Drug Resistance; Enzyme Inhibitors; Female; Malaria, Falciparum; Mice, SCID; Oxidoreductases Acting on CH-CH Group Donors; Parasites; Phenotype; Plasmodium falciparum; Point Mutation; Pyrimidines; Triazoles | 2019 |
Effects of a prolyl hydroxylase inhibitor on kidney and cardiovascular complications in a rat model of chronic kidney disease.
Topics: Animals; Apoptosis; Cell Line; Cytokines; Disease Models, Animal; Fibrosis; Hypertrophy, Left Ventricular; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation Mediators; Kidney; Male; Mitochondria, Heart; Myocytes, Cardiac; N-substituted Glycines; Neovascularization, Physiologic; Prolyl Hydroxylases; Prolyl-Hydroxylase Inhibitors; Pyridines; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; Signal Transduction; Triazoles; Ventricular Function, Left; Ventricular Remodeling | 2020 |
Hepatic Microwave Ablation-Induced Tumor Destruction and Animal End Point Survival Can Be Improved by Suppression of Heat Shock Protein 90.
Topics: Ablation Techniques; Animals; Apoptosis; Cell Proliferation; Disease Models, Animal; HSP90 Heat-Shock Proteins; Liver Neoplasms, Experimental; Mice; Mice, Nude; Microwaves; Survival; Treatment Outcome; Triazoles | 2020 |
Bromodomain-containing protein 4 inhibition alleviates matrix degradation by enhancing autophagy and suppressing NLRP3 inflammasome activity in NP cells.
Topics: Animals; Autophagy; Azepines; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Humans; Inflammasomes; Inflammation; Intervertebral Disc Degeneration; Macrolides; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Nuclear Proteins; Nucleus Pulposus; Rats; Signal Transduction; Transcription Factor RelA; Transcription Factors; Triazoles | 2020 |
Molecular mechanisms of posaconazole- and itraconazole-induced pseudohyperaldosteronism and assessment of other systemically used azole antifungals.
Topics: Aldosterone; Animals; Antifungal Agents; Azoles; Cricetinae; Disease Models, Animal; Drug Monitoring; HEK293 Cells; Humans; Hydrocortisone; Hyperaldosteronism; Hypertension; Hypothalamo-Hypophyseal System; Itraconazole; Mineralocorticoids; Steroid 11-beta-Hydroxylase; Steroid 17-alpha-Hydroxylase; Triazoles | 2020 |
Anticonvulsant and neurotoxic effects of a novel 1,2,4-triazole-3-thione derivative (TPF-34) and its isobolographic interaction profile with classical antiepileptic drugs in mice.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Male; Mice; Seizures; Time Factors; Tissue Distribution; Triazoles | 2020 |
Efficacy of the Benznidazole+Posaconazole combination therapy in parasitemia reduction: An experimental murine model of acute Chagas.
Topics: Acute Disease; Animals; Chagas Disease; Disease Models, Animal; Disease Progression; DNA, Protozoan; Drug Therapy, Combination; Nitroimidazoles; Parasite Load; Parasitemia; Rats; Rats, Wistar; Triazoles; Trypanocidal Agents | 2020 |
Enhancing neuronal chloride extrusion rescues α2/α3 GABA
Topics: Analgesia; Analgesics; Animals; Brain-Derived Neurotrophic Factor; Chlorides; Disease Models, Animal; Fluorobenzenes; GABA-A Receptor Agonists; Ion Transport; K Cl- Cotransporters; Ligands; Male; Neuralgia; Neurons; Peripheral Nerve Injuries; Rats; Rats, Sprague-Dawley; Receptor, trkB; Receptors, GABA-A; Symporters; Synapses; Triazoles | 2020 |
Inhibition of TGF-β signalling in combination with nal-IRI plus 5-Fluorouracil/Leucovorin suppresses invasion and prolongs survival in pancreatic tumour mouse models.
Topics: Aniline Compounds; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinogenesis; Cell Line, Tumor; Cell Movement; Disease Models, Animal; Drug Synergism; Epithelial-Mesenchymal Transition; Fluorouracil; Gene Expression Regulation, Neoplastic; Irinotecan; Leucovorin; Liposomes; Mice, Inbred C57BL; Nanoparticles; Neoplasm Invasiveness; Pancreatic Neoplasms; Signal Transduction; Survival Analysis; Transcriptome; Transforming Growth Factor beta; Triazoles; Tumor Stem Cell Assay; Up-Regulation | 2020 |
Combined Therapy of AXL and HDAC Inhibition Reverses Mesenchymal Transition in Diffuse Intrinsic Pontine Glioma.
Topics: Animals; Axl Receptor Tyrosine Kinase; Benzocycloheptenes; Biomarkers, Tumor; Blood-Brain Barrier; Cell Line, Tumor; Combined Modality Therapy; Diffuse Intrinsic Pontine Glioma; Disease Models, Animal; Drug Synergism; Epithelial-Mesenchymal Transition; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Immunohistochemistry; Mice; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Triazoles; Xenograft Model Antitumor Assays | 2020 |
Suvorexant ameliorates cognitive impairments and pathology in APP/PS1 transgenic mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Azepines; Chronobiology Disorders; Cognitive Dysfunction; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Gene Expression; Hippocampus; Long-Term Potentiation; Mice, Transgenic; Neuronal Plasticity; Neuroprostanes; Orexin Receptor Antagonists; Orexins; Triazoles | 2020 |
Short-term toxicogenomics as an alternative approach to chronic in vivo studies for derivation of points of departure: A case study in the rat with a triazole fungicide.
Topics: Administration, Oral; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Fungicides, Industrial; Liver; Male; Nitriles; No-Observed-Adverse-Effect Level; Organ Size; Rats; Rats, Sprague-Dawley; Testis; Time Factors; Toxicity Tests, Subacute; Toxicogenetics; Triazoles | 2020 |
Improved glucose tolerance with DPPIV inhibition requires β-cell SENP1 amplification of glucose-stimulated insulin secretion.
Topics: Animals; Cysteine Endopeptidases; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Exocytosis; Glucose; Glucose Intolerance; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Triazoles | 2020 |
3-Amino-1,2,4-Triazole Induces Quick and Strong Fat Loss in Mice with High Fat-Induced Metabolic Syndrome.
Topics: Animals; Body Weight; Disease Models, Animal; Male; Metabolic Syndrome; Mice; Triazoles | 2020 |
BET bromodomain-containing epigenetic reader proteins regulate vascular smooth muscle cell proliferation and neointima formation.
Topics: Animals; Azepines; Carotid Artery Injuries; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Proliferation; Cells, Cultured; Coronary Vessels; Cyclin-Dependent Kinase Inhibitor p21; Disease Models, Animal; Forkhead Box Protein O1; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Neointima; Nuclear Proteins; Proteins; Signal Transduction; Transcription Factors; Triazoles; Vascular System Injuries | 2021 |
Brd4-p300 inhibition downregulates Nox4 and accelerates lung fibrosis resolution in aged mice.
Topics: Acetanilides; Aging; Animals; Azepines; Disease Models, Animal; Gene Expression Regulation; Heterocyclic Compounds, 3-Ring; Histones; Humans; Lung; Mice; NADPH Oxidase 4; Nuclear Proteins; p300-CBP Transcription Factors; Pulmonary Fibrosis; Transcription Factors; Transforming Growth Factor beta1; Triazoles | 2020 |
Comparative immunopathogenesis in a murine model of inhalative infection with the mucormycetes Lichtheimia corymbifera and Rhizopus arrhizus.
Topics: Animals; Disease Models, Animal; Female; Inhalation; Mice; Mice, Inbred C57BL; Mucorales; Mucormycosis; Rhizopus; Survival Analysis; Triazoles | 2020 |
MK-5204: An orally active β-1,3-glucan synthesis inhibitor.
Topics: Administration, Oral; Animals; Antifungal Agents; beta-Glucans; Candida; Candidiasis; Disease Models, Animal; Glucosyltransferases; Glycosides; Half-Life; Mice; Microbial Sensitivity Tests; Stereoisomerism; Structure-Activity Relationship; Triazoles; Triterpenes | 2020 |
Correction of microtubule defects within Aβ plaque-associated dystrophic axons results in lowered Aβ release and plaque deposition.
Topics: Amyloid beta-Peptides; Animals; Axons; Brain; Disease Models, Animal; Female; Humans; Hydrocarbons, Halogenated; Male; Mice; Mice, Transgenic; Microtubules; Plaque, Amyloid; Triazoles | 2020 |
Long term follow-up of Trypanosoma cruzi infection and Chagas disease manifestations in mice treated with benznidazole or posaconazole.
Topics: Administration, Oral; Animals; Chagas Disease; Disease Models, Animal; Follow-Up Studies; Male; Mice, Inbred C57BL; Nitroimidazoles; Polymerase Chain Reaction; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Effects of post-renal anemia treatment with the HIF-PHD inhibitor molidustat on adenine-induced renal anemia and kidney disease in mice.
Topics: Acute Kidney Injury; Adenine; Anemia; Animals; Disease Models, Animal; Erythropoietin; Hypoxia-Inducible Factor 1; Male; Mice, Inbred C57BL; Prolyl-Hydroxylase Inhibitors; Pyrazoles; Triazoles | 2020 |
Non-selective orexin-receptor antagonist attenuates stress-re-stress-induced core PTSD-like symptoms in rats: Behavioural and neurochemical analyses.
Topics: Amygdala; Animals; Azepines; Corticosterone; Disease Models, Animal; Male; Orexin Receptor Antagonists; Orexins; Paroxetine; Rats; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; Selective Serotonin Reuptake Inhibitors; Serotonin; Stress Disorders, Post-Traumatic; Triazoles | 2021 |
BETs inhibition attenuates oxidative stress and preserves muscle integrity in Duchenne muscular dystrophy.
Topics: Animals; Azepines; Disease Models, Animal; Inflammation; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Muscle, Skeletal; Muscular Dystrophy, Duchenne; NADP; NADPH Oxidases; Neuromuscular Diseases; Nuclear Proteins; Oxidative Stress; Reactive Oxygen Species; Transcription Factors; Triazoles | 2020 |
BRD4 inhibition and FXR activation, individually beneficial in cholestasis, are antagonistic in combination.
Topics: Animals; Azepines; Bile Acids and Salts; Cell Cycle Proteins; Chenodeoxycholic Acid; Cholestasis; Cholesterol 7-alpha-Hydroxylase; Disease Models, Animal; Drug Interactions; Gene Knockdown Techniques; Humans; Liver; Liver Cirrhosis, Biliary; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; NF-kappa B; Nuclear Proteins; Nuclear Receptor Co-Repressor 2; Receptors, Cytoplasmic and Nuclear; Transcription Factors; Triazoles | 2020 |
A Novel Cryptococcal Meningitis Therapy: The Combination of Amphotericin B and Posaconazole Promotes the Distribution of Amphotericin B in the Brain Tissue.
Topics: Amphotericin B; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; Blood-Brain Barrier; Brain; Cryptococcus neoformans; Dibenzocycloheptenes; Diketopiperazines; Disease Models, Animal; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Meningitis, Cryptococcal; Mice; Molecular Docking Simulation; Quinolines; Serum Albumin; Tissue Distribution; Triazoles | 2020 |
Antifungal efficacy of isavuconazole and liposomal amphotericin B in a rabbit model of Exserohilum rostratum meningoencephalitis: A preclinical paradigm for management of CNS phaeohyphomycosis.
Topics: Amphotericin B; Animals; Antifungal Agents; Ascomycota; Central Nervous System Diseases; Disease Management; Disease Models, Animal; Drug Therapy, Combination; Female; Humans; Microbial Sensitivity Tests; Nitriles; Phaeohyphomycosis; Pyridines; Rabbits; Triazoles | 2021 |
Synthesis of Novel Triazolyl/Oxadiazolyl/Thiadiazolyl-Piperazine as Potential Anticonvulsant Agents.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Female; Humans; Male; Mice; Oxadiazoles; Piperazine; Rats; Seizures; Structure-Activity Relationship; Thiadiazoles; Toxicity Tests, Acute; Triazoles | 2021 |
A comparative study between two antifungal agents, Luliconazole and Efinaconazole, of their preventive effects in a Trichophyton-infected guinea pig onychomycosis model.
Topics: Administration, Topical; Animals; Antifungal Agents; Disease Models, Animal; Guinea Pigs; Imidazoles; Male; Specific Pathogen-Free Organisms; Tinea; Triazoles; Trichophyton | 2021 |
MCH-R1 Antagonist GPS18169, a Pseudopeptide, Is a Peripheral Anti-Obesity Agent in Mice.
Topics: Adipose Tissue; Alkynes; Aminobutyrates; Animals; Anti-Obesity Agents; Appetite; Aspartic Acid; Disease Models, Animal; Drug Discovery; Glutamic Acid; Glycine; HEK293 Cells; Hepatocytes; Homeostasis; Humans; Insulin; Lactams; Male; Mice; Mice, Inbred C57BL; Obesity; Rats; Receptors, Pituitary Hormone; Structure-Activity Relationship; Tissue Distribution; Triazoles | 2021 |
JQ1 as a BRD4 Inhibitor Blocks Inflammatory Pyroptosis-Related Acute Colon Injury Induced by LPS.
Topics: Animals; Azepines; Biomarkers; Colitis; Disease Models, Animal; Endotoxemia; Immunohistochemistry; Inflammasomes; Intestinal Mucosa; Lipopolysaccharides; Male; Mice; Nuclear Proteins; Phosphorylation; Pyroptosis; Tight Junctions; Transcription Factors; Triazoles | 2021 |
Structure-Activity Relationship of Heterocyclic P2Y
Topics: Animals; Binding Sites; Disease Models, Animal; Drug Design; Humans; Mice; Molecular Docking Simulation; Molecular Dynamics Simulation; Neuralgia; Piperidines; Prodrugs; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Solubility; Structure-Activity Relationship; Triazoles | 2021 |
Tricyclic Triazoles as σ
Topics: Analgesics; Animals; Cell Membrane Permeability; Disease Models, Animal; Female; Half-Life; Humans; Ligands; Male; Mice; Microsomes, Liver; Pain; Rats; Rats, Wistar; Receptors, sigma; Sigma-1 Receptor; Structure-Activity Relationship; Triazoles | 2021 |
Discovery of Novel Small-Molecule Antiangiogenesis Agents to Treat Diabetic Retinopathy.
Topics: Angiogenesis Inhibitors; Angiopoietin-2; Animals; Cell Survival; Diabetic Retinopathy; Disease Models, Animal; Down-Regulation; Drug Design; Drug Stability; Glucose; Human Umbilical Vein Endothelial Cells; Humans; Mice; Mice, Inbred C57BL; Neovascularization, Physiologic; Phosphatidylinositol 3-Kinases; Signal Transduction; Small Molecule Libraries; Structure-Activity Relationship; Triazoles | 2021 |
Effects of molidustat, a hypoxia-inducible factor prolyl hydroxylase inhibitor, on sodium dynamics in hypertensive subtotally nephrectomized rats.
Topics: Animals; Blood Pressure; Disease Models, Animal; Hypertension; Male; Nephrectomy; Prolyl-Hydroxylase Inhibitors; Pyrazoles; Rats, Wistar; Renal Insufficiency, Chronic; Sodium; Triazoles | 2021 |
Involvement of GRK2 in modulating nalfurafine-induced reduction of excessive alcohol drinking in mice.
Topics: Alcoholism; Animals; Benzamides; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Ethanol; G-Protein-Coupled Receptor Kinase 2; G-Protein-Coupled Receptor Kinase 3; Humans; Male; Mice; Morphinans; Nucleus Accumbens; Pyridines; Receptors, Opioid, kappa; Spiro Compounds; Triazoles | 2021 |
Arf6 exacerbates allergic asthma through cell-to-cell transmission of ASC inflammasomes.
Topics: ADP-Ribosylation Factor 6; Animals; Asthma; CARD Signaling Adaptor Proteins; Cell Communication; Disease Models, Animal; Humans; Inflammasomes; Interleukin-1beta; Lung; Macrophages, Alveolar; Mice; Mice, Knockout; Ovalbumin; Phagocytosis; Symptom Flare Up; Th2 Cells; THP-1 Cells; Triazoles | 2021 |
Inhibition of BET Proteins during Adolescence Affects Prefrontal Cortical Development: Relevance to Schizophrenia.
Topics: Adolescent; Adolescent Development; Animals; Azepines; Disease Models, Animal; Female; Gene Expression Regulation, Developmental; Humans; Long-Term Potentiation; Male; Methylazoxymethanol Acetate; Prefrontal Cortex; Proteomics; Rats; Recognition, Psychology; Schizophrenia; Sex Characteristics; Triazoles | 2021 |
Effects of Late Sodium Current Blockade on Ventricular Refibrillation in a Rabbit Model.
Topics: Animals; Calcium; Calcium Channels; Disease Models, Animal; Electric Countershock; Heart Arrest; Logistic Models; Pyridines; Rabbits; Random Allocation; Ranolazine; Reference Values; Sodium Channel Blockers; Sodium Channels; Statistics, Nonparametric; Triazoles; Ventricular Fibrillation | 2017 |
Exercise differentially affects metabolic functions and white adipose tissue in female letrozole- and dihydrotestosterone-induced mouse models of polycystic ovary syndrome.
Topics: Adipocytes; Adipogenesis; Adipose Tissue, White; Animals; Body Composition; Body Weight; Cell Size; Dihydrotestosterone; Disease Models, Animal; Feeding Behavior; Female; Gene Expression Regulation; Glucose Tolerance Test; Insulin Resistance; Letrozole; Lipid Metabolism; Liver; Mice, Inbred C57BL; Nitriles; Organ Size; Phenotype; Physical Conditioning, Animal; Polycystic Ovary Syndrome; Signal Transduction; Triazoles; Triglycerides | 2017 |
BH3-mimetics and BET-inhibitors elicit enhanced lethality in malignant glioma.
Topics: Acetanilides; Aniline Compounds; Animals; Antineoplastic Agents; Apoptosis; Azepines; Bcl-2-Like Protein 11; Caspases; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Drug Synergism; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Glioma; Heterocyclic Compounds, 3-Ring; Humans; Membrane Potential, Mitochondrial; Mice; Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; RNA, Small Interfering; Sulfonamides; Triazoles; Xenograft Model Antitumor Assays | 2017 |
Adenosine A
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adult; Aged; Animals; Brain Injuries, Traumatic; Cognitive Dysfunction; Disease Models, Animal; Female; Glycogen Synthase Kinase 3 beta; Glycogen Synthase Kinases; Hippocampus; Humans; Indoles; Isoquinolines; Male; Maleimides; Mice; Mice, Knockout; Middle Aged; Neurons; Phenethylamines; Phosphorylation; Protein Kinase Inhibitors; Receptor, Adenosine A2A; Signal Transduction; Sulfonamides; tau Proteins; Triazines; Triazoles | 2017 |
Micturition dysfunction in four-month old ovariectomized rats: Effects of testosterone replacement.
Topics: Acetanilides; Androgens; Angiotensin II; Animals; Carbachol; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Injections, Intramuscular; Letrozole; Muscle, Smooth; Nitriles; Ovariectomy; Postmenopause; Rats; Rats, Sprague-Dawley; Testosterone; Thiazoles; Triazoles; Urethra; Urination Disorders | 2017 |
Targeting the S1P/S1PR1 axis mitigates cancer-induced bone pain and neuroinflammation.
Topics: Animals; Breast Neoplasms; Cancer Pain; Cell Line, Tumor; Disease Models, Animal; Female; Fingolimod Hydrochloride; Gene Expression Regulation, Neoplastic; Immunosuppressive Agents; Interleukin-10; Mice; Mice, Inbred C57BL; Neurogenic Inflammation; Proprotein Convertases; Receptors, Lysosphingolipid; Serine Endopeptidases; Signal Transduction; Sphingosine-1-Phosphate Receptors; Spinal Cord; Sulfones; Triazoles | 2017 |
Design and Synthesis of 1,2,4-Triazolo[3,2-b]-1,3,5-thiadiazine Derivatives as a Novel Template for Analgesic/Anti-Inflammatory Activity.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Carrageenan; Disease Models, Animal; Drug Design; Edema; Hot Temperature; Mice; Molecular Structure; Pain; Stomach Ulcer; Thiadiazines; Triazoles | 2017 |
The cannabinoid ligand LH-21 reduces anxiety and improves glucose handling in diet-induced obese pre-diabetic mice.
Topics: Animals; Anxiety; Behavior, Animal; Blood Glucose; Diet, High-Fat; Disease Models, Animal; Inflammation Mediators; Insulin; Islets of Langerhans; Liver; Mice, Inbred C57BL; Obesity; Prediabetic State; Receptor, Cannabinoid, CB1; Triazoles | 2017 |
Oestrogen inhibition reverses pulmonary arterial hypertension and associated metabolic defects.
Topics: Anastrozole; Animals; Bone Morphogenetic Protein Receptors, Type II; Disease Models, Animal; Echocardiography; Estradiol; Estrogen Antagonists; Female; Fulvestrant; Hemodynamics; Humans; Hypertension, Pulmonary; Insulin Resistance; Lung; Mice; Mice, Knockout; Mutation; Nitriles; Signal Transduction; Tamoxifen; Triazoles | 2017 |
Rufinamide pretreatment attenuates ischemia-reperfusion injury in the gerbil hippocampus.
Topics: Animals; Astrocytes; Avoidance Learning; CA1 Region, Hippocampal; Carotid Artery Diseases; Disease Models, Animal; Gerbillinae; Ischemic Attack, Transient; Male; Microglia; Motor Activity; Neuroprotective Agents; Pyramidal Cells; Reperfusion Injury; Time Factors; Triazoles | 2017 |
Effect of vertical sleeve gastrectomy on alcohol consumption and preferences in dietary obese rats and mice: A plausible role for altered ghrelin signaling.
Topics: Alcohol Drinking; Analysis of Variance; Animals; Blood Glucose; Central Nervous System Depressants; Choice Behavior; Diet, High-Fat; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Food Preferences; Gastrectomy; Ghrelin; Glycine; Male; Mice; Mice, Inbred C57BL; Obesity; Rats; Rats, Sprague-Dawley; Signal Transduction; Triazoles | 2018 |
Does long-term androgen deficiency lead to metabolic syndrome in middle-aged rats?
Topics: Age Factors; Andropause; Animals; Aromatase Inhibitors; Biomarkers; Blood Glucose; Blood Pressure; Cholesterol; Disease Models, Animal; Estradiol; Female; Hormone Replacement Therapy; Hypogonadism; Letrozole; Liver; Liver Diseases; Male; Metabolic Syndrome; Nitriles; Orchiectomy; Ovariectomy; Rats, Inbred Lew; Sex Factors; Sexual Development; Testosterone; Triazoles; Uric Acid | 2017 |
Molecular mechanism of action and safety of 5-(3-chlorophenyl)-4-hexyl-2,4-dihydro-3
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Hep G2 Cells; Humans; Mice; Patch-Clamp Techniques; Seizures; Thiones; Triazoles; Voltage-Gated Sodium Channels | 2017 |
FTBMT, a Novel and Selective GPR52 Agonist, Demonstrates Antipsychotic-Like and Procognitive Effects in Rodents, Revealing a Potential Therapeutic Agent for Schizophrenia.
Topics: Animals; Antipsychotic Agents; Benzamides; CHO Cells; Cricetinae; Cricetulus; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Locomotion; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Nootropic Agents; Nucleus Accumbens; Organ Culture Techniques; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Rats, Wistar; Receptors, G-Protein-Coupled; Schizophrenia; Treatment Outcome; Triazoles | 2017 |
Selinexor (KPT-330) has antitumor activity against anaplastic thyroid carcinoma in vitro and in vivo and enhances sensitivity to doxorubicin.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Disease Models, Animal; Doxorubicin; Exportin 1 Protein; Heterografts; Humans; Hydrazines; Karyopherins; Models, Biological; Neoplasm Transplantation; Receptors, Cytoplasmic and Nuclear; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Treatment Outcome; Triazoles; Tumor Cells, Cultured | 2017 |
Liposomal Delivery of Diacylglycerol Lipase-Beta Inhibitors to Macrophages Dramatically Enhances Selectivity and Efficacy in Vivo.
Topics: Animals; Anti-Inflammatory Agents; Behavior, Animal; Disease Models, Animal; Enzyme Inhibitors; Humans; Hyperalgesia; Inflammation; Lipopolysaccharides; Lipoprotein Lipase; Liposomes; Macrophages; Male; Mice; Mice, Inbred C57BL; Pain; Phagocytosis; Treatment Outcome; Triazoles; Urea | 2018 |
Evaluation of the pharmacokinetic-pharmacodynamic relationship of praziquantel in the Schistosoma mansoni mouse model.
Topics: Animals; Anthelmintics; Chemoprevention; Chromatography, Liquid; Dexamethasone; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activators; Enzyme Inhibitors; Mice; Plasma; Praziquantel; Schistosoma mansoni; Schistosomiasis mansoni; Tandem Mass Spectrometry; Time Factors; Triazoles | 2017 |
Selective inhibition of physiological late Na
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Pacing, Artificial; Disease Models, Animal; Female; Heart Rate; Heart Ventricles; In Vitro Techniques; Isolated Heart Preparation; Kinetics; Myocytes, Cardiac; Piperidines; Pyridines; Rabbits; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin; Triazoles | 2018 |
Growth hormone secretagogues hexarelin and JMV2894 protect skeletal muscle from mitochondrial damages in a rat model of cisplatin-induced cachexia.
Topics: Animals; Autophagy; Biomarkers; Body Weight; Cachexia; Cisplatin; Disease Models, Animal; Forkhead Box Protein O3; Growth Hormone; Indoles; Male; Mitochondria; Mitochondrial Dynamics; Muscle, Skeletal; Oligopeptides; Organ Size; Organelle Biogenesis; Oxidative Stress; Phosphorylation; Piperidines; Proto-Oncogene Proteins c-akt; Rats; Secretagogues; Triazoles | 2017 |
Protective effects of deferasirox and N-acetyl-L-cysteine on iron overload-injured bone marrow.
Topics: Acetylcysteine; Animals; Benzoates; Colony-Forming Units Assay; Deferasirox; Disease Models, Animal; Flow Cytometry; Free Radical Scavengers; Hematopoiesis; Hematopoietic Stem Cells; Iron Chelating Agents; Iron Overload; Male; Mice, Inbred C57BL; Protective Agents; Reactive Oxygen Species; Reference Values; Reproducibility of Results; Time Factors; Treatment Outcome; Triazoles | 2017 |
Genome-wide mutagenesis and multi-drug resistance in American trypanosomes induced by the front-line drug benznidazole.
Topics: Animals; Chagas Disease; Disease Models, Animal; Drug Resistance, Multiple; Female; Genome, Protozoan; Mice, SCID; Mutagenesis; Mutagens; Mutation; Nitroimidazoles; Sequence Analysis, DNA; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2017 |
Evaluation of the efficacy of a posaconazole and anidulafungin combination in a murine model of pulmonary aspergillosis due to infection with Aspergillus fumigatus.
Topics: Anidulafungin; Animals; Antifungal Agents; Aspergillus fumigatus; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Echinocandins; Female; Lung; Mice; Pulmonary Aspergillosis; Treatment Outcome; Triazoles | 2018 |
JQ1 Induces DNA Damage and Apoptosis, and Inhibits Tumor Growth in a Patient-Derived Xenograft Model of Cholangiocarcinoma.
Topics: Animals; Apoptosis; Azepines; Bile Duct Neoplasms; Cholangiocarcinoma; Disease Models, Animal; DNA Damage; Gene Expression; Humans; Mice; Triazoles; Xenograft Model Antitumor Assays | 2018 |
Design, synthesis, and biological evaluation of new 1,2,3-triazolo-2'-deoxy-2'-fluoro- 4'-azido nucleoside derivatives as potent anti-HBV agents.
Topics: Animals; Antiviral Agents; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Ducks; Hep G2 Cells; Hepatitis B; Hepatitis B virus; Hepatitis B Virus, Duck; Humans; Models, Molecular; Molecular Structure; Monosaccharides; Nucleosides; Structure-Activity Relationship; Triazoles; Virus Replication | 2018 |
Azole-resistant and -susceptible Aspergillus fumigatus isolates show comparable fitness and azole treatment outcome in immunocompetent mice.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Azoles; Disease Models, Animal; Drug Resistance, Fungal; Female; Humans; Itraconazole; Lymphocyte Count; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Mutation; Spleen; Treatment Outcome; Triazoles; Virulence | 2018 |
CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM).
Topics: 14-alpha Demethylase Inhibitors; Amebicides; Animals; Antifungal Agents; Cell Proliferation; Central Nervous System Protozoal Infections; Disease Models, Animal; Drug Repositioning; Humans; Microscopy, Electron, Transmission; Naegleria fowleri; Nitriles; Pyridines; Sterol 14-Demethylase; Sterols; Triazoles; Trophozoites | 2017 |
Assessing drug efficacy against Plasmodium falciparum liver stages in vivo.
Topics: Animals; Antimalarials; Atovaquone; Disease Models, Animal; Drug Combinations; Drug Evaluation, Preclinical; Liver; Malaria, Falciparum; Mice; Plasmodium falciparum; Proguanil; Pyrimidines; Triazoles | 2018 |
Targeting BRD4 proteins suppresses the growth of NSCLC through downregulation of eIF4E expression.
Topics: A549 Cells; Animals; Azepines; Carcinoma, Non-Small-Cell Lung; Cell Cycle Proteins; Cell Line, Tumor; Disease Models, Animal; Down-Regulation; Eukaryotic Initiation Factor-4E; Heterocyclic Compounds, 4 or More Rings; Humans; Lung Neoplasms; Mice; Mice, Nude; Molecular Targeted Therapy; Nuclear Proteins; Random Allocation; Transcription Factors; Transfection; Triazoles; Xenograft Model Antitumor Assays | 2018 |
Adrenomedullin serves a role in the humoral pathway of delayed remote ischemic preconditioning via a hypoxia-inducible factor-1α-associated mechanism.
Topics: Adrenomedullin; Animals; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Indazoles; Ischemic Preconditioning; Kidney; Male; Malondialdehyde; Pyrazoles; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Superoxide Dismutase; Triazoles; Up-Regulation | 2018 |
Ganetespib limits ciliation and cystogenesis in autosomal-dominant polycystic kidney disease (ADPKD).
Topics: Animals; Aurora Kinase A; Cilia; Disease Models, Animal; HSP90 Heat-Shock Proteins; Humans; Mice; Mice, Knockout; NIMA-Related Kinases; Polycystic Kidney, Autosomal Dominant; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Triazoles | 2018 |
Maraviroc improves hepatic triglyceride content but not inflammation in a murine nonalcoholic fatty liver disease model induced by a chronic exposure to high-fat diet.
Topics: Animals; CCR5 Receptor Antagonists; Cyclohexanes; Diet, High-Fat; Disease Models, Animal; Insulin Resistance; Lipogenesis; Liver; Male; Maraviroc; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; PPAR gamma; Sterol Regulatory Element Binding Protein 1; Triazoles; Triglycerides | 2018 |
Impaired autophagic flux is associated with the severity of trauma and the role of A
Topics: Adenosine A2 Receptor Antagonists; Animals; Autophagosomes; Autophagy; Autophagy-Related Protein 12; Autophagy-Related Protein 5; Beclin-1; Brain Injuries, Traumatic; Cerebral Cortex; Chloroquine; Disease Models, Animal; Female; Gene Expression Regulation; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Microtubule-Associated Proteins; Neurons; Neuroprotective Agents; Receptor, Adenosine A2A; Sequestosome-1 Protein; Signal Transduction; Trauma Severity Indices; Triazines; Triazoles | 2018 |
Antiandrogen Treatment Ameliorates Reproductive and Metabolic Phenotypes in the Letrozole-Induced Mouse Model of PCOS.
Topics: Adipocytes; Androgen Antagonists; Animals; Aromatase Inhibitors; Body Weight; Disease Models, Animal; Estrous Cycle; Female; Flutamide; Follicle Stimulating Hormone; Letrozole; Luteinizing Hormone; Mice; Nitriles; Ovary; Phenotype; Pituitary Gland; Polycystic Ovary Syndrome; Receptors, LHRH; Reproduction; Steroid 17-alpha-Hydroxylase; Testosterone; Triazoles | 2018 |
Expression profiles of mRNA and long noncoding RNA in the ovaries of letrozole-induced polycystic ovary syndrome rat model through deep sequencing.
Topics: Animals; Disease Models, Animal; Female; Gene Expression Profiling; Gene Expression Regulation; Gene Ontology; Gene Regulatory Networks; High-Throughput Nucleotide Sequencing; Humans; Letrozole; Nitriles; Ovary; Polycystic Ovary Syndrome; Rats; RNA, Long Noncoding; RNA, Messenger; Sequence Analysis, RNA; Triazoles | 2018 |
Outcome of E1224-Benznidazole Combination Treatment for Infection with a Multidrug-Resistant Trypanosoma cruzi Strain in Mice.
Topics: Animals; Combined Modality Therapy; Disease Models, Animal; Drug Interactions; Female; Mice; Microbial Sensitivity Tests; Nitroimidazoles; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2018 |
Daily or weekly dosing with EGFR inhibitors, gefitinib and lapatinib, and AKt inhibitor MK2206 in mammary cancer models.
Topics: Animals; Disease Models, Animal; Drug Administration Schedule; ErbB Receptors; Female; Gefitinib; Heterocyclic Compounds, 3-Ring; Lapatinib; Male; Mammary Neoplasms, Experimental; Mice; Mice, Knockout; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Sprague-Dawley; Triazoles | 2018 |
Therapeutic potentials of Quercetin in management of polycystic ovarian syndrome using Letrozole induced rat model: a histological and a biochemical study.
Topics: Animals; Antioxidants; Biomarkers; Biopsy; Body Weight; Disease Management; Disease Models, Animal; Estrous Cycle; Female; Humans; Letrozole; Lipid Metabolism; Lipids; Nitriles; Ovarian Follicle; Ovary; Polycystic Ovary Syndrome; Quercetin; Rats; Triazoles | 2018 |
Tetragonia tetragonioides (Pall.) Kuntze Regulates Androgen Production in a Letrozole-Induced Polycystic Ovary Syndrome Model.
Topics: Aizoaceae; Androgens; Animals; Cell Line; Cell Survival; Cyclic AMP Response Element-Binding Protein; Dehydroepiandrosterone; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Female; Letrozole; Nitriles; Ovarian Follicle; Phytochemicals; Plant Extracts; Polycystic Ovary Syndrome; Rats; Signal Transduction; Testosterone; Triazoles | 2018 |
Comparison of the effects of deferasirox, deferoxamine, and combination of deferasirox and deferoxamine on an aplastic anemia mouse model complicated with iron overload.
Topics: Anemia, Aplastic; Animals; Benzoates; Deferasirox; Deferoxamine; Disease Models, Animal; Drug Therapy, Combination; Female; Iron Chelating Agents; Iron Overload; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Triazoles | 2018 |
Protective effect of the BET protein inhibitor JQ1 in cisplatin-induced nephrotoxicity.
Topics: A549 Cells; Animals; Antioxidants; Apoptosis; Azepines; Checkpoint Kinase 2; Cisplatin; Cytoprotection; Disease Models, Animal; DNA Damage; Enzyme Activation; Humans; Kidney Diseases; Kidney Tubules, Proximal; Male; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Nitrosative Stress; Oxidative Stress; Phosphorylation; Signal Transduction; Triazoles; Tumor Suppressor Protein p53; Weight Loss | 2018 |
The novel sodium channel modulator GS-458967 (GS967) is an effective treatment in a mouse model of SCN8A encephalopathy.
Topics: Action Potentials; Animals; Anticonvulsants; Brain Diseases; Disease Models, Animal; Drug Administration Schedule; Electroshock; Epilepsy; Female; Hippocampus; Humans; Male; Mice; Mice, Transgenic; Mutation; NAV1.6 Voltage-Gated Sodium Channel; Neurons; Off-Label Use; Phenytoin; Pyridines; Triazoles | 2018 |
Metformin and JQ1 synergistically inhibit obesity-activated thyroid cancer.
Topics: Animals; Antineoplastic Agents; Azepines; Cell Proliferation; Diet, High-Fat; Disease Models, Animal; Drug Synergism; Metformin; Mice; Mice, Knockout; Obesity; PTEN Phosphohydrolase; Thyroid Neoplasms; Triazoles | 2018 |
Galleria mellonella as a model system to study virulence potential of mucormycetes and evaluation of antifungal treatment.
Topics: Amphotericin B; Animals; Antifungal Agents; Disease Models, Animal; Drug Resistance, Fungal; Larva; Lepidoptera; Microbial Sensitivity Tests; Mucor; Mucorales; Mucormycosis; Nitriles; Pyridines; Rhizopus; Triazoles; Virulence | 2019 |
JAK-1 Inhibition Suppresses Interferon-Induced BAFF Production in Human Salivary Gland: Potential Therapeutic Strategy for Primary Sjögren's Syndrome.
Topics: Animals; B-Cell Activating Factor; Disease Models, Animal; Epithelial Cells; Humans; Interferons; Janus Kinase 1; Leukocytes, Mononuclear; Mice; Mice, Inbred NOD; Pyridines; RNA, Messenger; Salivary Glands; Signal Transduction; Sjogren's Syndrome; Triazoles | 2018 |
CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia.
Topics: Animals; Apoptosis; Azepines; Benzimidazoles; Cell Line, Tumor; Chromatin; Chromosomal Proteins, Non-Histone; Chromosome Inversion; Core Binding Factor Alpha 2 Subunit; Disease Models, Animal; DNA; DNA Helicases; Humans; Kaplan-Meier Estimate; Leukemia, Myeloid, Acute; Mice; Mice, Inbred C57BL; Nuclear Proteins; Oncogene Proteins, Fusion; Polycomb Repressive Complex 1; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Proteins c-myc; Transcription Factors; Triazoles | 2018 |
Hgf/Met activation mediates resistance to BRAF inhibition in murine anaplastic thyroid cancers.
Topics: Amino Acid Substitution; Animals; Antineoplastic Agents; Cell Line, Tumor; Coumarins; Crizotinib; Disease Models, Animal; Drug Resistance, Neoplasm; Genes, p53; Humans; Indoles; MAP Kinase Signaling System; Mice; Mice, Transgenic; Mutation, Missense; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-met; Pyrazines; Sulfonamides; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Triazoles | 2018 |
Nitric Oxide Releasing Nanoparticles as a Strategy to Improve Current Onychomycosis Treatments.
Topics: Administration, Topical; Animals; Antifungal Agents; Disease Models, Animal; Drug Carriers; Drug Liberation; Drug Synergism; Drug Therapy, Combination; Humans; Mice; Microbial Sensitivity Tests; Nanoparticles; Naphthalenes; Nitric Oxide; Onychomycosis; Permeability; Prescription Fees; Terbinafine; Treatment Outcome; Triazoles; Trichophyton | 2018 |
Enhancement of adenovirus infection and adenoviral vector-mediated gene delivery by bromodomain inhibitor JQ1.
Topics: Adenoviridae; Adenoviridae Infections; Administration, Oral; Animals; Azepines; Cyclin-Dependent Kinase 9; Disease Models, Animal; Enzyme Inhibitors; Epithelial Cells; Gene Transfer Techniques; Genetic Vectors; Lymphocytes; Mice; Nuclear Proteins; Protein Binding; Transcription Factors; Transformation, Genetic; Triazoles | 2018 |
Bromodomain and extraterminal domain-containing protein inhibition attenuates acute inflammation after spinal cord injury.
Topics: Animals; Animals, Newborn; Azepines; Cells, Cultured; Chromosomal Proteins, Non-Histone; Cytokines; Disease Models, Animal; Exploratory Behavior; Flow Cytometry; Gene Expression Regulation; Inflammation; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neuroglia; Nuclear Proteins; Receptors, Cell Surface; RNA, Messenger; Spinal Cord Injuries; Transcription Factors; Triazoles | 2018 |
EW-7197, an oral transforming growth factor β type I receptor kinase inhibitor, for preventing peritoneal adhesion formation in a rat model.
Topics: Administration, Oral; Aniline Compounds; Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Epithelial-Mesenchymal Transition; Female; Fibrosis; Humans; Peritoneal Diseases; Peritoneum; Postoperative Complications; Protein Kinase Inhibitors; Rats; Rats, Wistar; Receptor, Transforming Growth Factor-beta Type I; Signal Transduction; Surgical Procedures, Operative; Tissue Adhesions; Treatment Outcome; Triazoles | 2018 |
Effects of the Inhibition of Late Sodium Current by GS967 on Stretch-Induced Changes in Cardiac Electrophysiology.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Disease Models, Animal; Dose-Response Relationship, Drug; Isolated Heart Preparation; Male; Mechanoreceptors; Mechanotransduction, Cellular; Myocytes, Cardiac; Pyridines; Rabbits; Refractory Period, Electrophysiological; Sodium Channel Blockers; Sodium Channels; Time Factors; Triazoles; Ventricular Fibrillation | 2018 |
Oral administration of the casein kinase 2 inhibitor TBB leads to persistent K
Topics: Administration, Oral; Animals; Anticonvulsants; CA1 Region, Hippocampal; Casein Kinase II; Disease Models, Animal; Electric Stimulation; Electroencephalography; Hydrocarbons, Brominated; Male; Maze Learning; Muscarinic Agonists; Neurotransmitter Agents; Pilocarpine; Potassium Channels, Calcium-Activated; Rats; Rats, Wistar; Status Epilepticus; Triazoles; Up-Regulation; Video Recording | 2018 |
Ketoconazole and Posaconazole Selectively Target HK2-expressing Glioblastoma Cells.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Energy Metabolism; Gene Expression Regulation, Neoplastic; Glioblastoma; Hexokinase; Humans; Ketoconazole; Male; Mice; Triazoles; Xenograft Model Antitumor Assays | 2019 |
Phenotypic Screens Reveal Posaconazole as a Rapidly Acting Amebicidal Combination Partner for Treatment of Primary Amoebic Meningoencephalitis.
Topics: Amphotericin B; Animals; Antiprotozoal Agents; Azithromycin; Central Nervous System Protozoal Infections; Disease Models, Animal; Drug Combinations; Drug Discovery; Drug Synergism; Female; Fluconazole; Humans; Inhibitory Concentration 50; Mice; Naegleria fowleri; Phenotype; Time Factors; Triazoles; United States; United States Food and Drug Administration | 2019 |
A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model.
Topics: Alzheimer Disease; Animals; Axonal Transport; Axons; Brain; Disease Models, Animal; Humans; Mice; Microtubules; Neurons; Quinazolines; tau Proteins; Tauopathies; Triazoles | 2018 |
APX001 and Other Gwt1 Inhibitor Prodrugs Are Effective in Experimental
Topics: Aminopyridines; Amphotericin B; Animals; Antifungal Agents; Coccidioides; Disease Models, Animal; Female; Fluconazole; Isoxazoles; Mice; Mice, Inbred C57BL; Microbial Sensitivity Tests; Pneumonia; Prodrugs; Triazoles | 2019 |
Prevention of hepatic stellate cell activation using JQ1- and atorvastatin-loaded chitosan nanoparticles as a promising approach in therapy of liver fibrosis.
Topics: Actins; Animals; Atorvastatin; Azepines; Carbon Tetrachloride; Chitosan; Disease Models, Animal; Drug Carriers; Drug Evaluation, Preclinical; Drug Synergism; HEK293 Cells; Hepatic Stellate Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Liver Cirrhosis; Male; Mice; Nanoparticles; Nuclear Proteins; Transcription Factors; Treatment Outcome; Triazoles; Vitamin A | 2019 |
Chemokine (C-X-C motif) receptor 2 blockade by SB265610 inhibited angiotensin II-induced abdominal aortic aneurysm in Apo E
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Disease Models, Animal; Humans; Macrophages; Male; Mice; Mice, Knockout, ApoE; Phenylurea Compounds; Receptors, Interleukin-8B; Signal Transduction; Triazoles | 2019 |
CLIC4/Arf6 Pathway.
Topics: ADP-Ribosylation Factor 6; ADP-Ribosylation Factors; Animals; Antihypertensive Agents; Bone Morphogenetic Protein Receptors, Type II; Cells, Cultured; Chloride Channels; Disease Models, Animal; Endothelial Cells; Humans; Hypertension, Pulmonary; Hypoxia; Inflammation Mediators; Mice, Inbred C57BL; Mitochondrial Proteins; Molecular Targeted Therapy; Monocrotaline; Proteomics; Pulmonary Artery; Rats; RNA, Small Interfering; RNAi Therapeutics; Signal Transduction; Triazoles | 2019 |
A partial agonist for retinoid X receptor mitigates experimental colitis.
Topics: Animals; Cells, Cultured; Colitis; Cytokines; Dextran Sulfate; Disease Models, Animal; Docosahexaenoic Acids; Humans; Inflammation Mediators; Inflammatory Bowel Diseases; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred C57BL; Nuclear Receptor Subfamily 4, Group A, Member 1; PPAR delta; Protein Binding; Retinoid X Receptors; Tetrahydronaphthalenes; Triazoles | 2019 |
PET Imaging of the P2X7 Ion Channel with a Novel Tracer [
Topics: Animals; Biomarkers; Brain; Disease Models, Animal; Inflammation; Lipopolysaccharides; Peptides; Pilot Projects; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Pyridines; Radiopharmaceuticals; Rats; Receptors, Purinergic P2X7; Triazoles | 2019 |
TAS-203, an oral phosphodiesterase 4 inhibitor, exerts anti-inflammatory activities in a rat airway inflammation model.
Topics: Animals; Benzimidazoles; Cigarette Smoking; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Gene Expression Regulation; Goblet Cells; Guinea Pigs; Hyperplasia; Inflammation; Male; Mucin 5AC; Phosphodiesterase 4 Inhibitors; Pulmonary Disease, Chronic Obstructive; Rats; Respiratory System; Triazoles | 2019 |
Time-Dependent Bidirectional Neuroprotection by Adenosine 2A Receptor in Experimental Traumatic Brain Injury.
Topics: Adenosine; Animals; Brain Injuries; Brain Injuries, Traumatic; Disease Models, Animal; Male; Neuroprotection; Neuroprotective Agents; Phenethylamines; Pyrimidines; Rats, Wistar; Receptors, Purinergic P1; Signal Transduction; Time Factors; Triazoles | 2019 |
BRD4 inhibition attenuates inflammatory response in microglia and facilitates recovery after spinal cord injury in rats.
Topics: Animals; Azepines; Cells, Cultured; Disease Models, Animal; Gene Expression Regulation; Humans; Inflammation; MAP Kinase Kinase 1; Microglia; NF-kappa B; Nuclear Proteins; Rats; Recovery of Function; Signal Transduction; Spinal Cord; Spinal Cord Injuries; Transcription Factors; Triazoles | 2019 |
Magnesium Lithospermate B Derived from Salvia miltiorrhiza Ameliorates Right Ventricle Remodeling in Pulmonary Hypertensive Rats via Inhibition of NOX/VPO1 Pathway.
Topics: Animals; Atrial Natriuretic Factor; Benzoxazoles; Cell Hypoxia; Cell Line; Disease Models, Animal; Drugs, Chinese Herbal; Hemeproteins; Hypertension, Pulmonary; Male; Myocytes, Cardiac; NADPH Oxidase 2; NADPH Oxidase 4; NADPH Oxidases; Natriuretic Peptide, Brain; Peroxidases; Rats, Sprague-Dawley; Salvia miltiorrhiza; Triazoles; Ventricular Remodeling | 2019 |
The clinically licensed antifungal drug itraconazole inhibits influenza virus in vitro and in vivo.
Topics: A549 Cells; Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Repositioning; Human Umbilical Vein Endothelial Cells; Humans; Influenza A virus; Itraconazole; Mice; Mortality; Orthomyxoviridae Infections; Triazoles; Vero Cells; Viral Load; Virus Replication | 2019 |
Neurophysiological and Behavioral Effects of Anti-Orexinergic Treatments in a Mouse Model of Huntington's Disease.
Topics: Animals; Azepines; Cognitive Dysfunction; Disease Models, Animal; Female; Huntington Disease; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Orexin Receptor Antagonists; Orexins; Sleep Disorders, Circadian Rhythm; Triazoles | 2019 |
Vitamin C supplementation expands the therapeutic window of BETi for triple negative breast cancer.
Topics: Acetylation; Animals; Antineoplastic Agents; Apoptosis; Ascorbic Acid; Azepines; Cell Line, Tumor; Dietary Supplements; Disease Models, Animal; Drug Synergism; Female; Gene Expression Profiling; Gene Silencing; Histone Deacetylase 1; Humans; Mice; Proteins; Triazoles; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays | 2019 |
Tissue Distribution and Penetration of Isavuconazole at the Site of Infection in Experimental Invasive Aspergillosis in Mice with Underlying Chronic Granulomatous Disease.
Topics: Administration, Oral; Animals; Antifungal Agents; Aspergillosis; Chromatography, Liquid; Disease Models, Animal; Granulomatous Disease, Chronic; Invasive Fungal Infections; Male; Mice; Nitriles; Prodrugs; Pyridines; Tandem Mass Spectrometry; Tissue Distribution; Triazoles | 2019 |
SF2523: Dual PI3K/BRD4 Inhibitor Blocks Tumor Immunosuppression and Promotes Adaptive Immune Responses in Cancer.
Topics: Adaptive Immunity; Animals; Azepines; Cell Line, Tumor; Cell Polarity; Disease Models, Animal; Female; Immune Tolerance; Macrophages; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Morpholines; Neoplasms; Nuclear Proteins; Phosphoinositide-3 Kinase Inhibitors; Pyrans; Transcription Factors; Triazoles; Tumor Burden; Tumor Microenvironment | 2019 |
Therapeutic Targeting of BRD4 in Head Neck Squamous Cell Carcinoma.
Topics: Animals; Azepines; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Cycle Proteins; Cell Line, Tumor; Disease Models, Animal; Gene Expression Profiling; Head and Neck Neoplasms; Humans; Immunohistochemistry; Mice, SCID; Transcription Factors; Transplantation, Heterologous; Treatment Outcome; Triazoles | 2019 |
Rational design, cognition and neuropathology evaluation of QTC-4-MeOBnE in a streptozotocin-induced mouse model of sporadic Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Cognition; Disease Models, Animal; Male; Maze Learning; Memory Disorders; Mice; Molecular Docking Simulation; Neuroprotective Agents; Quinolines; Streptozocin; Triazoles | 2019 |
The BET inhibitor JQ1 attenuates double-strand break repair and sensitizes models of pancreatic ductal adenocarcinoma to PARP inhibitors.
Topics: Acid Anhydride Hydrolases; Animals; Azepines; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Disease Models, Animal; DNA Breaks, Double-Stranded; DNA Repair; DNA Repair Enzymes; DNA-Binding Proteins; Drug Resistance, Neoplasm; Female; Histones; Humans; Ku Autoantigen; Mice; Pancreatic Neoplasms; Phthalazines; Piperazines; Poly(ADP-ribose) Polymerase Inhibitors; Triazoles; Xenograft Model Antitumor Assays | 2019 |
AXL targeting reduces fibrosis development in experimental unilateral ureteral obstruction.
Topics: Animals; Axl Receptor Tyrosine Kinase; Benzocycloheptenes; Disease Models, Animal; Epithelial-Mesenchymal Transition; Extracellular Matrix Proteins; Fibrosis; Gene Expression Regulation; Inflammation Mediators; Kidney; Kidney Diseases; Macrophages; Male; Mice, Inbred C57BL; Myofibroblasts; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Signal Transduction; Triazoles; Ureteral Obstruction | 2019 |
Pharmacoproteomics reveal novel protective activity of bromodomain containing 4 inhibitors on vascular homeostasis in TLR3-mediated airway remodeling.
Topics: Airway Remodeling; Animals; Asthma; Azepines; Biomarkers, Pharmacological; Bleomycin; Blood Vessels; Bronchoalveolar Lavage Fluid; Case-Control Studies; Cell Cycle Proteins; Cytoprotection; Disease Models, Animal; Endothelium, Vascular; Homeostasis; Humans; Idiopathic Pulmonary Fibrosis; Male; Mice; Mice, Inbred C57BL; Poly I-C; Proteome; Proteomics; Respiratory Mucosa; Sulfonamides; Toll-Like Receptor 3; Transcription Factors; Triazoles | 2019 |
Pharmacodynamics of Isavuconazole in a Rabbit Model of Cryptococcal Meningoencephalitis.
Topics: Animals; Antifungal Agents; Area Under Curve; Brain; Cryptococcus neoformans; Disease Models, Animal; Male; Meningitis, Cryptococcal; Meningoencephalitis; Microbial Sensitivity Tests; Models, Theoretical; Nitriles; Pyridines; Rabbits; Triazoles | 2019 |
Synthesis and biological evaluation of (1,2,4)triazole[4,3-a]pyridine derivatives as potential therapeutic agents for concanavalin A-induced hepatitis.
Topics: Animals; Cell Survival; Cells, Cultured; Concanavalin A; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Female; Hepatitis; Humans; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Molecular Structure; Nitric Oxide; Pyridines; RAW 264.7 Cells; Structure-Activity Relationship; Triazoles | 2019 |
Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia.
Topics: Animals; Antineoplastic Agents; Biomarkers; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Electron Transport Complex I; Female; Hematopoiesis; Humans; Leukemia, Myeloid, Acute; Mice; Models, Biological; Oxazoles; Oxidative Phosphorylation; Protein Kinase Inhibitors; Receptor, ErbB-2; Triazoles | 2019 |
Growth arrest-specific protein-6/AXL signaling induces preeclampsia in rats†.
Topics: Animals; Apoptosis; Benzocycloheptenes; Blood Pressure; Cytokines; Disease Models, Animal; Female; Inflammation Mediators; Intercellular Signaling Peptides and Proteins; Mitochondria; Oxidative Stress; Phosphorylation; Pre-Eclampsia; Pregnancy; Rats; Rats, Sprague-Dawley; Signal Transduction; Triazoles | 2020 |
Bromodomain-containing protein 4 contributes to renal fibrosis through the induction of epithelial-mesenchymal transition.
Topics: Animals; Azepines; Case-Control Studies; Cell Cycle Proteins; Cells, Cultured; Disease Models, Animal; Disease Progression; Epithelial-Mesenchymal Transition; Fibrosis; Humans; Hypertension, Renal; Kidney; Male; Mice; Mice, Inbred C57BL; Nephritis; Nuclear Proteins; Transcription Factors; Triazoles | 2019 |
Anti-fungal activity of a novel triazole, PC1244, against emerging azole-resistant Aspergillus fumigatus and other species of Aspergillus.
Topics: Animals; Antifungal Agents; Aspergillus; Colony Count, Microbial; Disease Models, Animal; France; Galactose; Humans; India; Lung; Mannans; Mice; Microbial Sensitivity Tests; Netherlands; Pulmonary Aspergillosis; Treatment Outcome; Triazoles | 2019 |
Inhibition of BET bromodomain targets genetically diverse glioblastoma.
Topics: Animals; Azepines; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Models, Animal; Disease Progression; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Glioblastoma; Humans; Mice; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-myc; RNA Interference; Signal Transduction; Transcription, Genetic; Triazoles; Xenograft Model Antitumor Assays | 2013 |
Experimental models of disseminated scedosporiosis with cerebral involvement.
Topics: Animals; Antifungal Agents; Blood-Brain Barrier; Brain; Central Nervous System Fungal Infections; Disease Models, Animal; Dose-Response Relationship, Drug; Immunocompromised Host; Magnetic Resonance Imaging; Male; Pyrimidines; Rats; Rats, Sprague-Dawley; Scedosporium; Survival Analysis; Triazoles; Voriconazole | 2013 |
Synthesis and evaluation of the anticonvulsant activity of 8-alkoxy-4,5-dihydrobenzo[b][1,2,4]triazolo[4,3-d][1,4]thiazepine derivatives.
Topics: Animals; Anticonvulsants; Computational Biology; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Mice; Molecular Structure; Rotarod Performance Test; Seizures; Thiazepines; Triazoles | 2014 |
Synthesis and in-silico studies of some diaryltriazole derivatives as potential cyclooxygenase inhibitors.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Disease Models, Animal; Edema; Male; Models, Molecular; Molecular Docking Simulation; Rats; Rats, Sprague-Dawley; Triazoles | 2013 |
Antipsychotic-like effect of GLP-1 agonist liraglutide but not DPP-IV inhibitor sitagliptin in mouse model for psychosis.
Topics: Animals; Antipsychotic Agents; Apomorphine; Disease Models, Animal; Dopamine Agonists; Glucagon-Like Peptide 1; Liraglutide; Male; Mice; Psychotic Disorders; Pyrazines; Sitagliptin Phosphate; Statistics, Nonparametric; Triazoles | 2013 |
Antiarrhythmic effects of the highly selective late sodium channel current blocker GS-458967.
Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Disease Models, Animal; Dogs; Electrophysiological Phenomena; Heart Conduction System; Membrane Potentials; Pyridines; Sodium Channel Blockers; Triazoles | 2013 |
Synthesis and anticonvulsant activity evaluation of 4-(2-alkoxy-phenyl)-2,4-dihydro-3H-1,2,4-triazol-3-ones in various experimental seizure models in mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; gamma-Aminobutyric Acid; Mice; Seizures; Triazoles | 2013 |
A selective adenosine A2A receptor antagonist ameliorated hyperlocomotion in an animal model of lateral fluid percussion brain injury.
Topics: Adenosine A2 Receptor Antagonists; Animals; Brain Injuries; Disease Models, Animal; Exploratory Behavior; Gait Disorders, Neurologic; Gerbillinae; Percussion; Psychomotor Performance; Pyrimidines; Time Factors; Triazoles | 2013 |
Efficacy of the CCR5 antagonist maraviroc in reducing early, ritonavir-induced atherogenesis and advanced plaque progression in mice.
Topics: Animals; Anti-Retroviral Agents; Apolipoproteins E; Atherosclerosis; CCR5 Receptor Antagonists; Cell Movement; Chemokine CCL2; Chemokine CCL5; Cyclohexanes; Disease Models, Animal; Intercellular Adhesion Molecule-1; Interleukin-17; Macrophages; Male; Maraviroc; Mice; Mice, Inbred C57BL; Mice, Knockout; Plaque, Atherosclerotic; Ritonavir; Treatment Outcome; Triazoles; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2013 |
Efficacy of liposomal amphotericin B and posaconazole in intratracheal models of murine mucormycosis.
Topics: Amphotericin B; Animals; Antifungal Agents; Cortisone; Cyclophosphamide; Diabetic Ketoacidosis; Disease Models, Animal; Male; Mice; Mice, Inbred ICR; Mice, Inbred NOD; Microbial Sensitivity Tests; Mucorales; Mucormycosis; Triazoles | 2013 |
20-Hydroxyeicosatetraenoic acid inhibition attenuates balloon injury-induced neointima formation and vascular remodeling in rat carotid arteries.
Topics: Amidines; Angioplasty, Balloon, Coronary; Animals; Carotid Artery Injuries; Carotid Artery, Common; Carotid Stenosis; Cell Movement; Cell Proliferation; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Disease Models, Animal; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Hyperplasia; Male; Muscle, Smooth, Vascular; Neointima; Rats; Rats, Sprague-Dawley; Triazoles; Tunica Intima | 2013 |
Behavioral evidence for photophobia and stress-related ipsilateral head pain in transgenic Cacna1a mutant mice.
Topics: Analgesics; Animals; Calcium Channels, L-Type; Calcium Channels, N-Type; Disease Models, Animal; Dose-Response Relationship, Drug; Feces; Female; Functional Laterality; Headache; Male; Mice; Mice, Transgenic; Morphine; Mutation; Pain Measurement; Photophobia; Stress, Psychological; Triazoles; Tryptamines | 2013 |
Effect of combined therapy of human Wharton's jelly-derived mesenchymal stem cells from umbilical cord with sitagliptin in type 2 diabetic rats.
Topics: Animals; C-Peptide; Cell Proliferation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Glucagon; Glycated Hemoglobin; Hypoglycemic Agents; Insulin; Insulin-Secreting Cells; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Pyrazines; Rats; Rats, Wistar; Sitagliptin Phosphate; Streptozocin; Treatment Outcome; Triazoles; Umbilical Cord | 2014 |
Targeted inhibition of Hsp90 by ganetespib is effective across a broad spectrum of breast cancer subtypes.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Death; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Models, Animal; Female; HSP90 Heat-Shock Proteins; Humans; Inflammation; Mice, SCID; Molecular Targeted Therapy; Protein Stability; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Signal Transduction; Treatment Outcome; Triazoles; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays | 2014 |
Systemic iron chelation results in limited functional and histological recovery after traumatic spinal cord injury in rats.
Topics: Animals; Benzoates; Cervical Vertebrae; Deferasirox; Disease Models, Animal; Female; Iron Chelating Agents; Motor Activity; Rats; Rats, Sprague-Dawley; Recovery of Function; Spinal Cord; Spinal Cord Injuries; Triazoles | 2013 |
Strengthening context-dependent anticancer effects on non-small cell lung carcinoma by inhibition of both MET and EGFR.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Drug Synergism; ErbB Receptors; Erlotinib Hydrochloride; Humans; Lung Neoplasms; Mice; Molecular Targeted Therapy; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Pyridazines; Quinazolines; Signal Transduction; Small Cell Lung Carcinoma; Triazoles; Xenograft Model Antitumor Assays | 2013 |
Gadolinium-deferasirox-D-glucosamine: novel anti-tumor and MR molecular (theranostic) imaging agent.
Topics: Animals; Antineoplastic Agents; Benzoates; Cell Line, Tumor; Chromatography, Thin Layer; Contrast Media; Deferasirox; Disease Models, Animal; Gadolinium; Glucosamine; Glucose; Hexokinase; Humans; Magnetic Resonance Imaging; Mice, Nude; Microscopy, Fluorescence; Neoplasms; Phosphorylation; Radionuclide Imaging; Radiopharmaceuticals; Rats; Time Factors; Triazoles; Tumor Necrosis Factor-alpha | 2013 |
Assessment of Brd4 inhibition in idiopathic pulmonary fibrosis lung fibroblasts and in vivo models of lung fibrosis.
Topics: Acetylation; Animals; Anti-Inflammatory Agents; Antibiotics, Antineoplastic; Azepines; Bleomycin; Cell Cycle Proteins; Cell Movement; Cell Proliferation; Cells, Cultured; Connective Tissue Growth Factor; Cytokines; Disease Models, Animal; Fibroblasts; Growth Substances; Histones; Humans; Idiopathic Pulmonary Fibrosis; Interleukin-6; Male; Mice; Mice, Inbred C57BL; Nuclear Proteins; Skin; Transcription Factors; Triazoles | 2013 |
Targeting Myc in KSHV-associated primary effusion lymphoma with BET bromodomain inhibitors.
Topics: Animals; Antineoplastic Agents; Apoptosis; Azepines; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Cell Survival; Cellular Senescence; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Neoplastic; Herpesvirus 8, Human; Heterocyclic Compounds, 4 or More Rings; Humans; Inhibitory Concentration 50; Lymphoma, Primary Effusion; Nuclear Proteins; Protein Binding; Protein Transport; Proto-Oncogene Proteins c-myc; Transcription Factors; Transcription, Genetic; Triazoles; Tumor Burden; Virus Replication; Xenograft Model Antitumor Assays | 2014 |
A Novel Platelet-Activating Factor Receptor Antagonist Inhibits Choroidal Neovascularization and Subretinal Fibrosis.
Topics: Animals; Azepines; Choroidal Neovascularization; Disease Models, Animal; Female; Fibrosis; Hematologic Agents; Lasers; Macrophages; Mice, Inbred C57BL; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Retinal Diseases; RNA, Messenger; Triazoles | 2013 |
Selective tissue factor/factor VIIa Inhibitor, ER-410660, and its prodrug, E5539, have anti-venous and anti-arterial thrombotic effects with a low risk of bleeding.
Topics: Animals; Benzamidines; Blood Coagulation; Disease Models, Animal; Factor VIIa; Fibrinolytic Agents; Macaca mulatta; Male; Prodrugs; Random Allocation; Rats; Triazoles; Venous Thrombosis | 2013 |
Treatment of mercury vapor toxicity by combining deferasirox and deferiprone in rats.
Topics: Animals; Benzoates; Chelating Agents; Deferasirox; Deferiprone; Disease Models, Animal; Drug Therapy, Combination; Male; Mercury; Molecular Structure; Pyridones; Rats; Rats, Wistar; Tissue Distribution; Triazoles; Volatilization | 2013 |
Sitagliptin therapy enhances the number of circulating angiogenic cells and angiogenesis-evaluations in vitro and in the rat critical limb ischemia model.
Topics: Adipose Tissue; Animals; Arteries; Biomarkers; Cell Movement; Disease Models, Animal; Endothelial Cells; Hindlimb; Ischemia; Male; Neovascularization, Physiologic; Pyrazines; Rats; Rats, Inbred F344; Regional Blood Flow; Sitagliptin Phosphate; Stem Cells; Triazoles | 2013 |
Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: a role for A2A receptors.
Topics: Animals; Brain; Cannabidiol; Cardiovirus Infections; Cell Adhesion; Cells, Cultured; Chemokine CCL2; Chemokine CCL5; Disease Models, Animal; Endothelial Cells; Inflammation; Interleukin-1beta; Mice; Motor Activity; Multiple Sclerosis; Receptor, Adenosine A2A; Triazines; Triazoles; Vascular Cell Adhesion Molecule-1 | 2013 |
Inhibiting the HSP90 chaperone slows cyst growth in a mouse model of autosomal dominant polycystic kidney disease.
Topics: Animals; Cysts; Disease Models, Animal; HSP90 Heat-Shock Proteins; Kidney; Mice; Mice, Knockout; Polycystic Kidney, Autosomal Dominant; Proteolysis; Resorcinols; Signal Transduction; Triazoles; TRPP Cation Channels | 2013 |
Adenosine A2A receptor contributes to ischemic brain damage in newborn piglet.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Animals, Newborn; Blood Flow Velocity; Cerebrovascular Circulation; Corpus Striatum; Disease Models, Animal; Hypoxia-Ischemia, Brain; Immunohistochemistry; Laser-Doppler Flowmetry; Male; Neurons; Oxidative Stress; Phenethylamines; Pyrimidines; Receptor, Adenosine A2A; Sus scrofa; Triazoles | 2013 |
Synthesis and anticancer activity evaluation of a series of [1,2,4]triazolo[1,5-a]pyridinylpyridines in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HCT116 Cells; Humans; MCF-7 Cells; Mice; Models, Molecular; Molecular Structure; Neoplasms, Experimental; Pyridines; Structure-Activity Relationship; Triazoles; Tumor Cells, Cultured | 2013 |
Modest efficacy of voriconazole against murine infections by Sporothrix schenckii and lack of efficacy against Sporothrix brasiliensis.
Topics: Animals; Antifungal Agents; Colony Count, Microbial; Disease Models, Animal; Liver; Male; Mice; Pyrimidines; Spleen; Sporothrix; Sporotrichosis; Survival Analysis; Treatment Outcome; Triazoles; Voriconazole | 2014 |
The effects of DPP-IV inhibition in NOD mice with overt diabetes.
Topics: Animals; Diabetes Mellitus, Type 1; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Female; Islets of Langerhans; Lymph Nodes; Mice; Mice, Inbred NOD; Pyrazines; Sitagliptin Phosphate; Spleen; T-Lymphocyte Subsets; Time Factors; Triazoles | 2013 |
Circulating dipeptidyl peptidase IV activity correlates with cardiac dysfunction in human and experimental heart failure.
Topics: Adult; Aged; Animals; Apoptosis; Biomarkers; Case-Control Studies; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Female; Glucagon-Like Peptide 1; Heart Failure; Hemodynamics; Humans; Male; Middle Aged; Myocardium; Natriuretic Peptide, Brain; Pulmonary Edema; Pyrazines; Rats; Rats, Wistar; Sitagliptin Phosphate; Triazoles; Up-Regulation; Ventricular Function, Left; Ventricular Remodeling | 2013 |
Involvement of the dopaminergic and serotonergic systems in the antidepressant-like effect caused by 4-phenyl-1-(phenylselanylmethyl)-1,2,3-triazole.
Topics: Animals; Antidepressive Agents; Catalase; Cerebral Cortex; Chromatography, High Pressure Liquid; Depression; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Glutathione Transferase; Hippocampus; Male; Mice; Mice, Inbred C57BL; Norepinephrine; Organoselenium Compounds; Serotonin; Time Factors; Toxicity Tests, Acute; Triazoles | 2013 |
Benznidazole and posaconazole in experimental Chagas disease: positive interaction in concomitant and sequential treatments.
Topics: Animals; Antiprotozoal Agents; Chagas Disease; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Female; Mice; Nitroimidazoles; Parasitemia; Treatment Outcome; Triazoles; Trypanosoma cruzi | 2013 |
Isavuconazole pharmacodynamic target determination for Candida species in an in vivo murine disseminated candidiasis model.
Topics: Animals; Antifungal Agents; Area Under Curve; Candida albicans; Candida glabrata; Candida tropicalis; Candidiasis; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Half-Life; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Nitriles; Pyridines; Species Specificity; Triazoles | 2013 |
Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseases.
Topics: Animals; Cell Differentiation; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Gene Silencing; Humans; Inflammation; Inhibitory Concentration 50; Interleukin-6; Janus Kinase 1; Male; Mice; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Rats; STAT1 Transcription Factor; T-Lymphocytes, Helper-Inducer; Triazoles | 2013 |
Chelation of thallium by combining deferasirox and desferrioxamine in rats.
Topics: Animals; Benzoates; Chelation Therapy; Deferasirox; Deferoxamine; Disease Models, Animal; Dose-Response Relationship, Drug; Iron; Iron Chelating Agents; Male; Rats; Rats, Wistar; Spectrophotometry, Atomic; Thallium; Triazoles | 2016 |
The effect of dipeptidyl peptidase-IV inhibition on bone in a mouse model of type 2 diabetes.
Topics: Animals; Blood Glucose; Body Weight; Bone and Bones; Cell Differentiation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Histocytochemistry; Male; Mice; Osteoblasts; Polymerase Chain Reaction; RNA; Triazoles; X-Ray Microtomography | 2014 |
Protective effects of sitagliptin on myocardial injury and cardiac function in an ischemia/reperfusion rat model.
Topics: Animals; Apoptosis; Body Weight; Cardiotonic Agents; Creatine Kinase, MB Form; Disease Models, Animal; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Glutathione Peroxidase; Heart; Heart Ventricles; L-Lactate Dehydrogenase; Male; Malondialdehyde; Myocytes, Cardiac; Organ Size; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Glucagon; Reperfusion Injury; Sitagliptin Phosphate; Superoxide Dismutase; Triazoles | 2013 |
Enhanced brain delivery of deferasirox-lactoferrin conjugates for iron chelation therapy in neurodegenerative disorders: in vitro and in vivo studies.
Topics: Alzheimer Disease; Animals; Apoptosis; Apoptosis Regulatory Proteins; Benzoates; Brain; Carbodiimides; Cell Line, Tumor; Chelating Agents; Chelation Therapy; Deferasirox; Disease Models, Animal; Drug Delivery Systems; Iron; Lactoferrin; Male; Nanostructures; Neurodegenerative Diseases; Neuroprotective Agents; PC12 Cells; Permeability; Rats; Rats, Wistar; Transcytosis; Triazoles | 2013 |
HDAC inhibitor entinostat restores responsiveness of letrozole-resistant MCF-7Ca xenografts to aromatase inhibitors through modulation of Her-2.
Topics: Animals; Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Benzamides; Disease Models, Animal; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; HSP90 Heat-Shock Proteins; Humans; Letrozole; MAP Kinase Signaling System; MCF-7 Cells; Mice; Nitriles; Pyridines; Receptor, ErbB-2; RNA Stability; Triazoles; Tumor Burden; Xenograft Model Antitumor Assays | 2013 |
MitoPark mice, an animal model of Parkinson's disease, show enhanced prepulse inhibition of acoustic startle and no loss of gating in response to the adenosine A(2A) antagonist SCH 412348.
Topics: Adenosine A2 Receptor Antagonists; Aging; Animals; Apomorphine; Benzothiazoles; Disease Models, Animal; Dopamine Agonists; Male; Mice; Mice, Transgenic; Motor Activity; Parkinson Disease; Pramipexole; Prepulse Inhibition; Pyrimidines; Triazoles | 2014 |
Preclinical activity profile and therapeutic efficacy of the HSP90 inhibitor ganetespib in triple-negative breast cancer.
Topics: Animals; Antineoplastic Agents; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Disease Models, Animal; DNA Damage; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Drug Synergism; Female; HSP90 Heat-Shock Proteins; Humans; Lung Neoplasms; Mice; Mitosis; Neoplasm Metastasis; Neoplasm Staging; Positron-Emission Tomography; Tomography, X-Ray Computed; Triazoles; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays | 2014 |
Antagonism of the adenosine A2A receptor attenuates akathisia-like behavior induced with MP-10 or aripiprazole in a novel non-human primate model.
Topics: Adenosine A2 Receptor Antagonists; Akathisia, Drug-Induced; Animals; Antipsychotic Agents; Aripiprazole; Behavior, Animal; Cebus; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Haloperidol; Humans; Male; Motor Activity; Phosphodiesterase Inhibitors; Piperazines; Pyrazoles; Pyrimidines; Quinolines; Quinolones; Triazoles | 2014 |
Selective inhibition of late sodium current suppresses ventricular tachycardia and fibrillation in intact rat hearts.
Topics: Aconitine; Action Potentials; Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Male; Pyridines; Rats; Rats, Inbred F344; Tachycardia, Ventricular; Triazoles; Ventricular Fibrillation | 2014 |
Combination therapy with iron chelation and vancomycin in treating murine staphylococcemia.
Topics: Animals; Anti-Bacterial Agents; Bacteremia; Bacterial Load; Benzoates; Chelating Agents; Deferasirox; Disease Models, Animal; Drug Therapy, Combination; Iron; Kidney; Methicillin-Resistant Staphylococcus aureus; Mice, Inbred BALB C; Microbial Sensitivity Tests; Microbial Viability; Severity of Illness Index; Spleen; Staphylococcal Infections; Treatment Outcome; Triazoles; Vancomycin | 2014 |
Sitagliptin reduces cardiac apoptosis, hypertrophy and fibrosis primarily by insulin-dependent mechanisms in experimental type-II diabetes. Potential roles of GLP-1 isoforms.
Topics: Animals; Apoptosis; Cardiomegaly; Cardiotonic Agents; Cells, Cultured; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Disease Models, Animal; Drug Evaluation, Preclinical; Fibroblasts; Fibronectins; Fibrosis; Glucagon-Like Peptide 1; Glucose Intolerance; Hypoglycemic Agents; Insulin; Male; Metformin; Myocardium; Myocytes, Cardiac; PPAR delta; Protein Isoforms; Pyrazines; Rats; Sitagliptin Phosphate; Triazoles | 2013 |
Protective mechanisms of adenosine 5'-monophosphate in platelet activation and thrombus formation.
Topics: Adenosine A2 Receptor Agonists; Adenosine Monophosphate; Animals; Blood Platelets; CD40 Ligand; Cells, Cultured; Crotalid Venoms; Cyclic Nucleotide Phosphodiesterases, Type 3; Disease Models, Animal; Humans; Lasers; Lectins, C-Type; Mesenteric Veins; Mice; Molecular Targeted Therapy; P-Selectin; Peptide Fragments; Photochemical Processes; Platelet Activation; Platelet Glycoprotein GPIIb-IIIa Complex; Receptor, Adenosine A2A; Rose Bengal; Stereoisomerism; Thrombosis; Triazines; Triazoles | 2014 |
Efficacy of the combination of voriconazole and caspofungin in experimental pulmonary aspergillosis by different Aspergillus species.
Topics: Animals; Antifungal Agents; Aspergillus flavus; Aspergillus fumigatus; Aspergillus niger; Caspofungin; Disease Models, Animal; Drug Therapy, Combination; Echinocandins; Galactose; Humans; Lipopeptides; Male; Mannans; Microbial Sensitivity Tests; Neutropenia; Pulmonary Aspergillosis; Pyrimidines; Rats; Rats, Sprague-Dawley; Treatment Outcome; Triazoles; Voriconazole | 2014 |
Uncoupling protein-2 mediates DPP-4 inhibitor-induced restoration of endothelial function in hypertension through reducing oxidative stress.
Topics: Animals; Cyclooxygenase 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Endothelium, Vascular; Exenatide; Gene Expression Regulation; Humans; Hypertension; Ion Channels; Male; Mice; Mitochondria; Mitochondrial Proteins; Models, Biological; Oxidative Stress; Peptides; Pyrazines; Rats; Rats, Inbred SHR; Reactive Oxygen Species; Renal Artery; Sitagliptin Phosphate; Triazoles; Uncoupling Protein 2; Vasoconstriction; Venoms | 2014 |
Cooperative role of endogenous leucotrienes and platelet-activating factor in ischaemia-reperfusion-mediated tissue injury.
Topics: Amidines; Animals; Azepines; Biological Assay; Carbamates; Dermis; Disease Models, Animal; Extravasation of Diagnostic and Therapeutic Materials; Extremities; Inflammation; Leukotriene B4; Leukotrienes; Male; Mice; Mice, Inbred C57BL; Myocardial Ischemia; Neutrophil Infiltration; Platelet Activating Factor; Platelet Membrane Glycoproteins; Propionates; Quinolines; Rabbits; Receptors, G-Protein-Coupled; Receptors, Leukotriene; Reperfusion Injury; Triazoles | 2013 |
Effect of sitagliptin treatment on metabolism and cardiac function in genetic diabetic mice.
Topics: Adiponectin; Animals; Blood Glucose; Body Weight; Diabetes Mellitus; Diet, High-Fat; Disease Models, Animal; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Heart; Heart Function Tests; Hypoglycemic Agents; Insulin; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Myocardium; Pyrazines; Sitagliptin Phosphate; Triazoles | 2014 |
Design, synthesis and evaluation of the antidepressant and anticonvulsant activities of triazole-containing quinolinones.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Electroshock; Exploratory Behavior; Male; Mice; Mice, Inbred Strains; Molecular Structure; Quinolones; Rotarod Performance Test; Seizures; Swimming; Triazoles | 2014 |
Characterization of the exocrine pancreas in the male Zucker diabetic fatty rat model of type 2 diabetes mellitus following 3 months of treatment with sitagliptin.
Topics: Administration, Oral; Animals; Blood Glucose; Body Weight; Cell Proliferation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Hypoglycemic Agents; Keratins; Ki-67 Antigen; Male; Metformin; Pancreas, Exocrine; Pyrazines; Rats; Rats, Zucker; Sitagliptin Phosphate; Triazoles | 2014 |
Inhibition of casein kinase II reduces TGFβ induced fibroblast activation and ameliorates experimental fibrosis.
Topics: Adult; Aged; Animals; Casein Kinase II; Disease Models, Animal; Female; Fibroblasts; Fibrosis; Humans; Janus Kinase 2; Male; Mice; Middle Aged; Scleroderma, Systemic; Signal Transduction; Skin; STAT3 Transcription Factor; Transforming Growth Factor beta; Triazoles; Young Adult | 2015 |
Activation of platelet-activating factor receptor exacerbates renal inflammation and promotes fibrosis.
Topics: Animals; Azepines; Collagen; Disease Models, Animal; Fibrosis; Kidney; Mice; Mice, Inbred BALB C; Mice, Knockout; Nephritis; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Renal Insufficiency, Chronic; Triazoles; Ureteral Obstruction | 2014 |
Intrapulmonary posaconazole penetration at the infection site in an immunosuppressed murine model of invasive pulmonary aspergillosis receiving oral prophylactic regimens.
Topics: Administration, Oral; Animals; Antifungal Agents; Disease Models, Animal; Female; Invasive Pulmonary Aspergillosis; Mice; Triazoles | 2014 |
In vivo treatment with the casein kinase 2 inhibitor 4,5,6,7- tetrabromotriazole augments the slow afterhyperpolarizing potential and prevents acute epileptiform activity.
Topics: Animals; Anticonvulsants; CA1 Region, Hippocampal; Casein Kinase II; Disease Models, Animal; Epilepsy, Temporal Lobe; Hydrocarbons, Brominated; Male; Membrane Potentials; Patch-Clamp Techniques; Pilocarpine; Rats; Rats, Wistar; Triazoles | 2014 |
Cytohesins/ARNO: the function in colorectal cancer cells.
Topics: Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Disease Models, Animal; ErbB Receptors; Gene Expression; Gene Knockdown Techniques; GTPase-Activating Proteins; Heterografts; Humans; Male; Mice; Receptor, IGF Type 1; Signal Transduction; Triazoles; Tumor Burden; Xenograft Model Antitumor Assays | 2014 |
Synthesis of some novel 1,2,4-triazol-3-one derivatives bearing the salicyl moiety and their anticonvulsant activities.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Design; Electroshock; Mice; Molecular Structure; Salicylates; Seizures; Structure-Activity Relationship; Time Factors; Triazoles | 2014 |
Maraviroc, a CCR5 antagonist, ameliorates the development of hepatic steatosis in a mouse model of non-alcoholic fatty liver disease (NAFLD).
Topics: Animals; Cyclohexanes; Disease Models, Animal; Fatty Liver; Histocytochemistry; Liver; Liver Function Tests; Male; Maraviroc; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Triazoles | 2014 |
Enhancement of inhibitory neurotransmission by GABAA receptors having α2,3-subunits ameliorates behavioral deficits in a mouse model of autism.
Topics: Animals; Autistic Disorder; Behavior, Animal; Benzodiazepines; Brain; Disease Models, Animal; Fluorobenzenes; Interpersonal Relations; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Protein Subunits; Pyridines; Receptors, GABA-A; Social Behavior; Synaptic Transmission; Triazoles; Zolpidem | 2014 |
Host biomarkers of invasive pulmonary aspergillosis to monitor therapeutic response.
Topics: Amphotericin B; Animals; Annexin A1; Antifungal Agents; Aspergillus fumigatus; Biomarkers; Bronchoalveolar Lavage Fluid; C-Reactive Protein; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Humans; Invasive Pulmonary Aspergillosis; Neutropenia; Proteomics; Rabbits; Thiazoles; Triazoles | 2014 |
CCR5 inhibition prevents cardiac dysfunction in the SIV/macaque model of HIV.
Topics: Animals; CCR5 Receptor Antagonists; Cyclohexanes; Diastole; Disease Models, Animal; Echocardiography, Doppler; Heart Ventricles; HIV Fusion Inhibitors; Ligands; Macaca mulatta; Maraviroc; Myocytes, Cardiac; Receptors, CCR5; Signal Transduction; Simian Acquired Immunodeficiency Syndrome; Triazoles; Ventricular Dysfunction; Ventricular Function; Viral Load | 2014 |
Transcriptome analysis of the hippocampus in novel rat model of febrile seizures.
Topics: Animals; Cell Line, Tumor; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Gene Expression Profiling; Gene Ontology; Gene Regulatory Networks; Hippocampus; Pyrazines; Rats; Rats, Sprague-Dawley; Seizures, Febrile; Sitagliptin Phosphate; Triazoles | 2014 |
Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer.
Topics: Androgen Antagonists; Androgens; Animals; Azepines; Cell Cycle Proteins; Cell Line, Tumor; Disease Models, Animal; Epigenesis, Genetic; Humans; Male; Mice; Nuclear Proteins; Oncogene Proteins, Fusion; Prostatic Neoplasms, Castration-Resistant; Protein Structure, Tertiary; Receptors, Androgen; Signal Transduction; Transcription Factors; Triazoles | 2014 |
Comparative activity of proline-containing dipeptide noopept and inhibitor of dipeptidyl peptidase-4 sitagliptin in a rat model of developing diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Proline; Pyrazines; Rats; Rats, Wistar; Sitagliptin Phosphate; Triazoles | 2014 |
Dipeptidyl peptidase inhibition prevents diastolic dysfunction and reduces myocardial fibrosis in a mouse model of Western diet induced obesity.
Topics: Animals; Cardiomyopathies; Diastole; Diet; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Fibrosis; Male; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Obesity; Triazoles | 2014 |
Experimental treatment of Curvularia infection.
Topics: Amphotericin B; Animals; Antifungal Agents; Ascomycota; Disease Models, Animal; Immunocompromised Host; Male; Mice; Mycoses; Treatment Outcome; Triazoles; Voriconazole | 2014 |
Triazolopyridyl ketones as a novel class of antileishmanial agents. DNA binding and BSA interaction.
Topics: Animals; Antiprotozoal Agents; Binding, Competitive; Cattle; Cell Line; Cell Survival; Disease Models, Animal; DNA; Ketones; Leishmania; Leishmaniasis; Liver; Mice; Protein Binding; Pyridines; Serum Albumin, Bovine; Spectrometry, Fluorescence; Spleen; Triazoles | 2014 |
Sex-dependent influence of endogenous estrogen in pulmonary hypertension.
Topics: Anastrozole; Animals; Aromatase Inhibitors; Blotting, Western; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Estrogens; Female; Humans; Hypertension, Pulmonary; Hypoxia; Lung; Male; Mice; Mice, Inbred C57BL; Nitriles; Polymerase Chain Reaction; Rats; Rats, Wistar; Sex Factors; Triazoles | 2014 |
Stimulation of intestinal growth and function with DPP4 inhibition in a mouse short bowel syndrome model.
Topics: Adaptation, Physiological; Amylases; Animals; Blood Glucose; Cell Proliferation; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Glucagon-Like Peptide 2; Glucagon-Like Peptide-2 Receptor; Intestinal Absorption; Intestinal Mucosa; Jejunum; Male; Mice; Receptor, IGF Type 1; Receptors, Glucagon; Short Bowel Syndrome; Sodium-Glucose Transporter 1; Triazoles; Up-Regulation | 2014 |
Helium preconditioning protects mouse liver against ischemia and reperfusion injury through the PI3K/Akt pathway.
Topics: Adenosine A2 Receptor Antagonists; Animals; Apoptosis; Disease Models, Animal; Helium; Ischemic Preconditioning; Liver; Liver Transplantation; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Reperfusion Injury; Signal Transduction; Transplantation Conditioning; Triazines; Triazoles; Warm Ischemia | 2014 |
CCR5 as a treatment target in pulmonary arterial hypertension.
Topics: Animals; CCR5 Receptor Antagonists; Cell Proliferation; Cells, Cultured; Cyclohexanes; Disease Models, Animal; Familial Primary Pulmonary Hypertension; HIV Fusion Inhibitors; HIV Infections; Humans; Hypertension, Pulmonary; Hypoxia; Macaca mulatta; Macrophages; Male; Maraviroc; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Pulmonary Artery; Receptors, CCR5; Simian Acquired Immunodeficiency Syndrome; Triazoles | 2014 |
Significance of vascular dipeptidyl peptidase-4 inhibition on vascular protection in Zucker diabetic fatty rats.
Topics: Animals; Atherosclerosis; Blood Glucose; Carotid Arteries; Chemokine CCL2; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Gene Expression; Glucose Tolerance Test; In Vitro Techniques; Insulin; Linagliptin; Malondialdehyde; NADPH Oxidases; Purines; Pyrazines; Quinazolines; Rats, Zucker; Sitagliptin Phosphate; Triazoles; Vasodilation | 2014 |
Adenosine 2A receptor occupancy by tozadenant and preladenant in rhesus monkeys.
Topics: Animals; Benzothiazoles; Brain; Chromatography, High Pressure Liquid; Disease Models, Animal; Heterocyclic Compounds, 3-Ring; Humans; Macaca mulatta; Parkinson Disease; Positron-Emission Tomography; Pyrimidines; Radiometry; Receptor, Adenosine A2A; Time Factors; Triazoles; Whole Body Imaging | 2014 |
Anti-hyperalgesic effects of a novel TRPM8 agonist in neuropathic rats: a comparison with topical menthol.
Topics: Analgesics; Animals; Cold Temperature; Disease Models, Animal; Hyperalgesia; Male; Menthol; Morpholines; Neuralgia; Pain Threshold; Peripheral Nerve Injuries; Rats; Rats, Sprague-Dawley; Triazoles; TRPM Cation Channels | 2014 |
Studies on the anticonvulsant activity and influence on GABA-ergic neurotransmission of 1,2,4-triazole-3-thione- based compounds.
Topics: Animals; Anticonvulsants; Disease Models, Animal; GABA Agents; Male; Mice; Seizures; Synaptic Transmission; Toxicity Tests; Triazoles | 2014 |
HIV pre-exposure prophylaxis: mucosal tissue drug distribution of RT inhibitor Tenofovir and entry inhibitor Maraviroc in a humanized mouse model.
Topics: Adenine; Animals; Anti-HIV Agents; Cyclohexanes; Disease Models, Animal; Female; HIV Infections; HIV-1; Humans; Maraviroc; Mice; Mucous Membrane; Organophosphonates; Pre-Exposure Prophylaxis; Reverse Transcriptase Inhibitors; Tenofovir; Triazoles; Virus Internalization | 2014 |
PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies.
Topics: Animals; Azepines; Cell Cycle Proteins; Cell Death; Chromatin; Disease Models, Animal; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Glioma; Humans; Melanoma; Mice; Mitogen-Activated Protein Kinase Kinases; Neoplasm Proteins; Neoplasms; Nerve Sheath Neoplasms; Neurofibromin 1; Nuclear Proteins; Polycomb Repressive Complex 2; ras Proteins; Transcription Factors; Transcription, Genetic; Triazoles; Tumor Suppressor Proteins | 2014 |
Nedd9 restrains renal cystogenesis in Pkd1-/- mice.
Topics: Adaptor Proteins, Signal Transducing; Animals; Aurora Kinase A; Calcium Signaling; Cilia; Disease Models, Animal; Epithelial Cells; Female; HSP90 Heat-Shock Proteins; Kidney; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Polycystic Kidney, Autosomal Dominant; Primary Cell Culture; Triazoles; TRPP Cation Channels | 2014 |
Inconsistent hepatic antifibrotic effects with the iron chelator deferasirox.
Topics: Actins; Administration, Oral; Animals; Benzoates; Cells, Cultured; Deferasirox; Disease Models, Animal; Gene Expression; Hepatic Stellate Cells; Humans; Iron Chelating Agents; Liver; Liver Cirrhosis; Male; Matrix Metalloproteinase 2; Mice; Mice, Transgenic; Procollagen; Triazoles | 2015 |
Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome.
Topics: Animals; Anti-Mullerian Hormone; Aromatase Inhibitors; Disease Models, Animal; Female; Letrozole; Nitriles; Ovarian Follicle; Ovary; Polycystic Ovary Syndrome; Rats; Rats, Sprague-Dawley; Receptors, Peptide; Receptors, Transforming Growth Factor beta; Testosterone; Triazoles | 2014 |
Comparative pharmacodynamics of posaconazole in neutropenic murine models of invasive pulmonary aspergillosis and mucormycosis.
Topics: Amphotericin B; Animals; Antifungal Agents; Area Under Curve; Aspergillosis; Aspergillus fumigatus; Benzoates; Caspofungin; Deferasirox; Disease Models, Animal; Drug Therapy, Combination; Echinocandins; Female; Invasive Pulmonary Aspergillosis; Lipopeptides; Lung; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Mucormycosis; Neutropenia; Rhizopus; Treatment Outcome; Triazoles | 2014 |
Effect of dipeptidyl peptidase 4 inhibition on arterial blood pressure is context dependent.
Topics: Animals; Blood Pressure; Blood Pressure Determination; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Glucagon-Like Peptide 1; Hypertension; Male; Pyrazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sitagliptin Phosphate; Treatment Outcome; Triazoles | 2015 |
Triazolopyridines as selective JAK1 inhibitors: from hit identification to GLPG0634.
Topics: Adenosine Triphosphate; Animals; Arthritis; Chemistry, Pharmaceutical; Collagen; Crohn Disease; Crystallography, X-Ray; Cytokines; Dimerization; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; Humans; Inhibitory Concentration 50; Janus Kinase 1; Kinetics; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Rats; Recombinant Proteins; Structure-Activity Relationship; Triazoles | 2014 |
Hyperactivation of D1 and A2A receptors contributes to cognitive dysfunction in Huntington's disease.
Topics: Adenosine A2 Receptor Antagonists; Animals; Benzazepines; Cognition Disorders; Corpus Striatum; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Dopamine Antagonists; Hippocampus; Huntington Disease; Long-Term Potentiation; Male; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Motor Activity; Pyrimidines; Receptor, Adenosine A2A; Receptors, Dopamine D1; Triazoles | 2015 |
Prenatal hyperandrogenic environment induced autistic-like behavior in rat offspring.
Topics: Androgens; Animals; Arginine Vasopressin; Child Development Disorders, Pervasive; Disease Models, Animal; Estrous Cycle; Female; Letrozole; Male; Nitriles; Oxytocin; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Sprague-Dawley; Receptors, Vasopressin; RNA, Messenger; Sex Characteristics; Social Behavior; Sound; Testosterone; Triazoles; Vocalization, Animal | 2015 |
Micafungin alone and in combination therapy with deferasirox against Pythium insidiosum.
Topics: Animals; Antifungal Agents; Benzoates; Deferasirox; Disease Models, Animal; Drug Therapy, Combination; Echinocandins; Female; Horse Diseases; Horses; Lipopeptides; Micafungin; Microbial Sensitivity Tests; Pythiosis; Pythium; Rabbits; Triazoles | 2015 |
Alteration of hedgehog signaling by chronic exposure to different pesticide formulations and unveiling the regenerative potential of recombinant sonic hedgehog in mouse model of bone marrow aplasia.
Topics: Anemia, Aplastic; Animals; Bone Marrow Cells; Cell Cycle; Chlorpyrifos; Disease Models, Animal; Femur; Hedgehog Proteins; Humans; Male; Mice; Pesticides; Pyrethrins; Recombinant Proteins; Signal Transduction; Stromal Cells; Triazoles | 2015 |
MK-0626, a selective DPP-4 inhibitor, attenuates hepatic steatosis in ob/ob mice.
Topics: Adiponectin; AMP-Activated Protein Kinases; Animals; Biomarkers; Cytoprotection; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Fatty Liver; Gene Expression Regulation; Lipogenesis; Liver; Male; Mice, Obese; Obesity; Signal Transduction; Time Factors; Triazoles; Triglycerides | 2014 |
Short-term inhibition of DPP-4 enhances endothelial regeneration after acute arterial injury via enhanced recruitment of circulating progenitor cells.
Topics: Acute Disease; Animals; Arterial Occlusive Diseases; Carotid Arteries; Cell Movement; Cell Proliferation; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Endothelium, Vascular; Male; Mice; Mice, Inbred C57BL; Pyrazines; Regeneration; Signal Transduction; Sitagliptin Phosphate; Stem Cells; Triazoles; Tunica Intima | 2014 |
Novel role for endogenous hepatocyte growth factor in the pathogenesis of intracranial aneurysms.
Topics: Adult; Aged; Aneurysm, Ruptured; Animals; Cells, Cultured; Disease Models, Animal; E-Selectin; Endothelium, Vascular; Female; Hepatocyte Growth Factor; Humans; Intracranial Aneurysm; Male; Mice; Mice, Inbred C57BL; Middle Aged; Muscle, Smooth, Vascular; Proto-Oncogene Proteins c-met; Pyrazines; Signal Transduction; Triazoles; Vascular Cell Adhesion Molecule-1 | 2015 |
Exploring in vitro and in vivo Hsp90 inhibitors activity against human protozoan parasites.
Topics: Animals; Antiprotozoal Agents; Cell Line, Tumor; Disease Models, Animal; HSP90 Heat-Shock Proteins; Humans; Mice; Parasitemia; Plasmodium falciparum; Protein Binding; Rats; Triazoles; Trypanosoma brucei rhodesiense | 2015 |
Calcium signaling mediates antifungal activity of triazole drugs in the Aspergilli.
Topics: Animals; Antifungal Agents; Aspergillus fumigatus; Aspergillus nidulans; Calcium Chelating Agents; Calcium Signaling; Culture Media; Disease Models, Animal; Egtazic Acid; Gene Expression Profiling; Invasive Pulmonary Aspergillosis; Itraconazole; Lepidoptera; Real-Time Polymerase Chain Reaction; Treatment Outcome; Triazoles | 2015 |
Prophylaxis of acute graft-versus-host disease by CCR5 blockade combined with cyclosporine A in a murine model.
Topics: Animals; CCR5 Receptor Antagonists; Cyclohexanes; Cyclosporine; Cytokines; Disease Models, Animal; Drug Synergism; Female; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Immunosuppressive Agents; Intestines; Liver; Male; Maraviroc; Mice, Inbred BALB C; Mice, Inbred C57BL; Receptors, CCR5; Receptors, CCR7; Receptors, CXCR3; Triazoles | 2015 |
Efficacy of oleylphosphocholine (OlPC) in vitro and in a mouse model of invasive aspergillosis.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus; Aspergillus fumigatus; Azoles; Disease Models, Animal; Mice; Microbial Sensitivity Tests; Phosphorylcholine; Pyrimidines; Triazoles; Voriconazole | 2015 |
Gliptin and GLP-1 analog treatment improves survival and vascular inflammation/dysfunction in animals with lipopolysaccharide-induced endotoxemia.
Topics: Animals; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Endotoxemia; Glucagon-Like Peptide 1; Inflammation; Linagliptin; Lipopolysaccharides; Liraglutide; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidative Stress; Purines; Pyrazines; Quinazolines; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Sitagliptin Phosphate; Triazoles | 2015 |
Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis.
Topics: Animals; Anti-Inflammatory Agents; Cell Survival; Cells, Cultured; Disease Models, Animal; Disease Progression; Drug Therapy, Combination; Embryonic Stem Cells; Endometriosis; Estrogens; Female; Fertility; Humans; Indazoles; Inflammation; Letrozole; Ligands; Macrophages; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Nitriles; Receptors, Estrogen; Stromal Cells; Treatment Outcome; Triazoles | 2015 |
Preclinical pharmacological evaluation of letrozole as a novel treatment for gliomas.
Topics: Animals; Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Cell Line, Tumor; Cytochrome P-450 CYP1A1; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Activation; Female; Gene Expression; Glioma; Humans; Letrozole; Nitriles; Positron-Emission Tomography; Rats; Triazoles; X-Ray Microtomography; Xenograft Model Antitumor Assays | 2015 |
Time-course of protection by the selective A2A receptor antagonist SCH58261 after transient focal cerebral ischemia.
Topics: Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Blood Cells; Body Weight; Brain Injuries; Disease Models, Animal; Ischemic Attack, Transient; Male; Myelin-Associated Glycoprotein; Neurologic Examination; Pyrimidines; Rats; Rats, Wistar; Time Factors; Triazoles | 2015 |
Selinexor is effective in acquired resistance to ibrutinib and synergizes with ibrutinib in chronic lymphocytic leukemia.
Topics: Adenine; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Drug Resistance, Neoplasm; Drug Synergism; Humans; Hydrazines; Leukemia, Lymphocytic, Chronic, B-Cell; Mice; Piperidines; Pyrazoles; Pyrimidines; Triazoles; Xenograft Model Antitumor Assays | 2015 |
Electrophysiological characterization of activation state-dependent Ca(v)2 channel antagonist TROX-1 in spinal nerve injured rats.
Topics: Acetone; Action Potentials; Animals; Calcium Channel Blockers; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Ganglia, Spinal; Hyperalgesia; Indoles; Male; omega-Conotoxins; Pain Measurement; Pain Threshold; Patch-Clamp Techniques; Peripheral Nerve Injuries; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Spinal Nerves; Triazoles | 2015 |
Evolution and synthesis of novel orally bioavailable inhibitors of PDE10A.
Topics: Administration, Oral; Animals; Biological Availability; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Humans; Locomotion; Models, Molecular; Molecular Structure; Phencyclidine; Phosphoric Diester Hydrolases; Rats; Structure-Activity Relationship; Triazoles | 2015 |
Novel thiazolo[3,2-b]-1,2,4-triazoles derived from naproxen with analgesic/anti-inflammatory properties: Synthesis, biological evaluation and molecular modeling studies.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Models, Animal; Drug Design; Edema; Humans; Inflammation; Mice; Molecular Docking Simulation; Molecular Dynamics Simulation; Naproxen; Nociception; Pain; Pain Measurement; Structure-Activity Relationship; Thiazoles; Thiones; Triazoles | 2015 |
Deletion of adenosine A2A receptors from astrocytes disrupts glutamate homeostasis leading to psychomotor and cognitive impairment: relevance to schizophrenia.
Topics: Animals; Astrocytes; Cognition Disorders; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 2; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glutamic Acid; Homeostasis; Kainic Acid; Locomotion; Mice; Mice, Inbred C57BL; Mice, Transgenic; Psychomotor Disorders; Pyrimidines; Receptor, Adenosine A2A; Receptors, N-Methyl-D-Aspartate; Synaptosomes; Time Factors; Triazoles | 2015 |
Therapeutic targeting of BET bromodomain protein, Brd4, delays cyst growth in ADPKD.
Topics: Animals; Azepines; Cell Cycle Proteins; Cell Proliferation; Cysts; Disease Models, Animal; Epigenesis, Genetic; Epithelial Cells; Female; Gene Targeting; HEK293 Cells; HSP90 Heat-Shock Proteins; Humans; Male; Mice, Knockout; Nuclear Proteins; Phosphorylation; Polycystic Kidney, Autosomal Dominant; Protein Kinase C; Proto-Oncogene Proteins c-myc; Transcription Factors; Triazoles; TRPP Cation Channels; Up-Regulation | 2015 |
[Study on the oxidative stress in the ovaries of a rat model of polycystic ovary].
Topics: Animals; Antioxidants; Disease Models, Animal; Estrogens; Female; Follicle Stimulating Hormone; Letrozole; Luteinizing Hormone; Malondialdehyde; Nitriles; Ovary; Oxidative Stress; Polycystic Ovary Syndrome; Progesterone; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Testosterone; Triazoles | 2015 |
Animal models of Parkinson׳s disease: Effects of two adenosine A2A receptor antagonists ST4206 and ST3932, metabolites of 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine (ST1535).
Topics: Adenine; Adenosine A2 Receptor Antagonists; Administration, Oral; Animals; Antiparkinson Agents; Basal Ganglia; Binding, Competitive; Catalepsy; Cyclic AMP; Disease Models, Animal; Dose-Response Relationship, Drug; Haloperidol; HEK293 Cells; Humans; Injections, Intraperitoneal; Ligands; Male; Mice; Motor Activity; Oxidopamine; Parkinsonian Disorders; Protein Binding; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Transfection; Triazoles | 2015 |
Dual targeting of TNF-α and free radical toxic stress as a promising strategy to manage experimental polycystic ovary.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Disease Models, Animal; Drug Therapy, Combination; Female; Gonadal Steroid Hormones; Hyperandrogenism; Inflammation Mediators; Letrozole; Lipid Peroxidation; Nitriles; Ovary; Oxidative Stress; Plant Extracts; Polycystic Ovary Syndrome; Rats, Wistar; Reactive Oxygen Species; Triazoles; Tumor Necrosis Factor-alpha | 2016 |
The HSP90 Inhibitor Ganetespib Alleviates Disease Progression and Augments Intermittent Cyclophosphamide Therapy in the MRL/lpr Mouse Model of Systemic Lupus Erythematosus.
Topics: Animals; B-Lymphocytes; Cyclophosphamide; Cytokines; Disease Models, Animal; Disease Progression; HSP90 Heat-Shock Proteins; Humans; Immunosuppressive Agents; Lupus Erythematosus, Systemic; Mice; Spleen; T-Lymphocytes; Triazoles | 2015 |
Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment.
Topics: Alleles; Allografts; Animals; Apoptosis; Cell Line, Tumor; Disease Models, Animal; Female; Histone Deacetylase 6; Histone Deacetylases; HSP90 Heat-Shock Proteins; Humans; Lymphoma; Male; Mice; Molecular Targeted Therapy; Mutant Proteins; Neoplasm Transplantation; Protein Stability; Survival Rate; Tamoxifen; Triazoles; Tumor Suppressor Protein p53 | 2015 |
Limited Ability of Posaconazole To Cure both Acute and Chronic Trypanosoma cruzi Infections Revealed by Highly Sensitive In Vivo Imaging.
Topics: Animals; Antifungal Agents; Chagas Disease; Chronic Disease; Disease Models, Animal; Female; Mice; Mice, Inbred BALB C; Mice, SCID; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Rufinamide Improves Functional and Behavioral Deficits via Blockade of Tetrodotoxin-Resistant Sodium Channels in Diabetic Neuropathy.
Topics: Animals; Biophysical Phenomena; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Ganglia, Spinal; Mental Disorders; Neural Conduction; Neurons; Patch-Clamp Techniques; Rats; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin; Triazoles | 2015 |
The Novel μ-Opioid Receptor Antagonist GSK1521498 Decreases Both Alcohol Seeking and Drinking: Evidence from a New Preclinical Model of Alcohol Seeking.
Topics: Alcohol Deterrents; Alcohol Drinking; Alcohol-Related Disorders; Animals; Blood Alcohol Content; Choice Behavior; Conditioning, Operant; Cues; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug-Seeking Behavior; Indans; Male; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid, mu; Reinforcement, Psychology; Species Specificity; Triazoles | 2015 |
Differential effects of ghrelin antagonists on alcohol drinking and reinforcement in mouse and rat models of alcohol dependence.
Topics: Alcohol Drinking; Alcoholism; Animals; Central Nervous System Agents; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Food Preferences; Ghrelin; Glycine; Male; Mice, Inbred C57BL; Random Allocation; Rats, Wistar; Receptors, Ghrelin; Reinforcement, Psychology; Self Administration; Triazoles | 2015 |
Synthesis and Anticonvulsant Activity Evaluation of 4-Phenyl-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one and Its Derivatives.
Topics: Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Brain; Disease Models, Animal; Drug Design; Electroshock; Mice; Molecular Structure; Motor Activity; Pentylenetetrazole; Quinazolinones; Rotarod Performance Test; Seizures; Structure-Activity Relationship; Time Factors; Triazoles | 2015 |
Small molecule inhibitors of PSD95-nNOS protein-protein interactions as novel analgesics.
Topics: Aminosalicylic Acids; Analgesics; Animals; Ataxia; Benzylamines; Brain; Cell Death; Cells, Cultured; Chlorophenols; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hyperalgesia; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Nitric Oxide Synthase Type I; Nociceptive Pain; Rats, Sprague-Dawley; Triazoles | 2015 |
Protection Against Rectal Chimeric Simian/Human Immunodeficiency Virus Transmission in Macaques by Rectal-Specific Gel Formulations of Maraviroc and Tenofovir.
Topics: Administration, Topical; Animals; Anti-HIV Agents; Cross-Over Studies; Cyclohexanes; Disease Models, Animal; Disease Transmission, Infectious; Gels; Macaca; Maraviroc; Placebos; Simian Acquired Immunodeficiency Syndrome; Tenofovir; Treatment Outcome; Triazoles | 2015 |
Colocalization of aromatase in spinal cord astrocytes: differences in expression and relationship to mechanical and thermal hyperalgesia in murine models of a painful and a non-painful bone tumor.
Topics: Analysis of Variance; Animals; Antineoplastic Agents; Aromatase; Bone Neoplasms; Cell Line, Tumor; Disease Models, Animal; Fibrosarcoma; Gene Expression Regulation, Neoplastic; Glial Fibrillary Acidic Protein; Hyperalgesia; Letrozole; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Microglia; Nerve Tissue Proteins; Nitriles; Pain; Pain Threshold; Spinal Cord; Triazoles | 2015 |
Synthesis and Characterization of New 1,2,4-Triazolo[1,5-a]pyridines That Extend the Life Span of Caenorhabiditis elegans via Their Anti-Inflammatory/Antioxidant Effects.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biphenyl Compounds; Caenorhabditis elegans; Carrageenan; Dextrans; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Edema; Glycation End Products, Advanced; Glycosylation; Heat-Shock Response; Longevity; Male; Molecular Structure; Oxidative Stress; Picrates; Pyridines; Rats; Structure-Activity Relationship; Time Factors; Triazoles | 2015 |
Targeting bromodomain-containing protein 4 (BRD4) benefits rheumatoid arthritis.
Topics: Animals; Apoptosis; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantibodies; Azepines; Cell Cycle Proteins; Cell Movement; Cell Proliferation; Cell Survival; Complement C2; Cytokines; Disease Models, Animal; Gene Expression; Gene Targeting; Humans; Inflammation Mediators; JNK Mitogen-Activated Protein Kinases; Mice; NF-kappa B; Nuclear Proteins; RNA Interference; RNA, Small Interfering; Transcription Factors; Transfection; Triazoles | 2015 |
Registered report: BET bromodomain inhibition as a therapeutic strategy to target c-Myc.
Topics: Animals; Antineoplastic Agents; Azepines; Disease Models, Animal; Down-Regulation; Gene Expression Regulation; Mice; Multiple Myeloma; Proto-Oncogene Proteins c-myc; Survival Analysis; Treatment Outcome; Triazoles | 2015 |
A nude mouse model of obesity to study the mechanisms of resistance to aromatase inhibitors.
Topics: Adipose Tissue; Animals; Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Blood Glucose; Cell Line, Tumor; Cyclooxygenase 2; Diet; Disease Models, Animal; Drug Resistance, Neoplasm; Estrogens; Humans; Insulin; Letrozole; Mice, Nude; Neoplasms; Nitriles; Obesity; Ovariectomy; Triazoles; Tumor Burden | 2015 |
Triazole analog 1-(1-benzyl-5-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)-2-(4-bromophenylamino)-1-(4-chlorophenyl)ethanol induces reactive oxygen species and autophagy-dependent apoptosis in both in vitro and in vivo breast cancer models.
Topics: Animals; Apoptosis; Autophagy; Breast Neoplasms; Cell Line, Tumor; Disease Models, Animal; Ethanol; Female; HEK293 Cells; Humans; Mammary Neoplasms, Experimental; MCF-7 Cells; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Triazoles | 2015 |
Imiquimod-induced psoriasis-like skin inflammation is suppressed by BET bromodomain inhibitor in mice through RORC/IL-17A pathway modulation.
Topics: Aminoquinolines; Animals; Azepines; Disease Models, Animal; Imiquimod; Inflammation; Interleukin-17; Interleukin-22; Interleukins; Male; Mice; Mice, Inbred BALB C; Nuclear Receptor Subfamily 1, Group F, Member 3; Psoriasis; Signal Transduction; Skin; Triazoles | 2015 |
Selective late INa inhibition by GS-458967 exerts parallel suppression of catecholamine-induced hemodynamically significant ventricular tachycardia and T-wave alternans in an intact porcine model.
Topics: Animals; Blood Pressure; Disease Models, Animal; Electrocardiography; Epinephrine; Heart Rate; Pyridines; Swine; Tachycardia, Ventricular; Triazoles | 2015 |
Beneficial properties of maraviroc on neuropathic pain development and opioid effectiveness in rats.
Topics: Analgesics, Opioid; Animals; Astrocytes; Buprenorphine; CCR5 Receptor Antagonists; Cells, Cultured; Chronic Disease; Cyclohexanes; Cytokines; Disease Models, Animal; Drug Synergism; Ganglia, Spinal; Hyperalgesia; Lipopolysaccharides; Male; Maraviroc; Microglia; Morphine; Neuralgia; Rats, Wistar; Sciatic Nerve; Spinal Cord; Triazoles | 2016 |
JTP-103237, a monoacylglycerol acyltransferase inhibitor, prevents fatty liver and suppresses both triglyceride synthesis and de novo lipogenesis.
Topics: Acyltransferases; Animals; Antigens, Bacterial; Bacterial Proteins; Diglycerides; Disease Models, Animal; Enzyme Inhibitors; Fatty Acids; Fatty Liver; Gene Expression; Intestinal Absorption; Lipogenesis; Liver; Male; Mice, Inbred C57BL; Piperazines; Sterol Regulatory Element Binding Protein 1; Triazoles; Triglycerides | 2015 |
Antitrypanosomal Treatment with Benznidazole Is Superior to Posaconazole Regimens in Mouse Models of Chagas Disease.
Topics: 14-alpha Demethylase Inhibitors; Administration, Oral; Animals; Chagas Disease; Clinical Trials, Phase II as Topic; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Heart; Humans; Immunosuppression Therapy; Mice; NIH 3T3 Cells; Nitroimidazoles; Parasitemia; Recurrence; Sterol 14-Demethylase; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Electrophysiological evidence for voltage-gated calcium channel 2 (Cav2) modulation of mechano- and thermosensitive spinal neuronal responses in a rat model of osteoarthritis.
Topics: Animals; Calcium Channel Blockers; Caveolin 2; Disease Models, Animal; Evoked Potentials; Functional Laterality; Hyperalgesia; Indoles; Iodoacetic Acid; Male; Neurons; omega-Conotoxins; Osteoarthritis; Pain Measurement; Rats; Rats, Sprague-Dawley; Transcutaneous Electric Nerve Stimulation; Triazoles | 2015 |
Salviaolate Protects Rat Brain from Ischemia-Reperfusion Injury through Inhibition of NADPH Oxidase.
Topics: Animals; Antioxidants; Benzofurans; Benzoxazoles; Brain; Brain Ischemia; Cells, Cultured; China; Cinnamates; Depsides; Disease Models, Animal; Drugs, Chinese Herbal; Male; NADPH Oxidases; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Rosmarinic Acid; Salvia miltiorrhiza; Triazoles | 2015 |
Discovery of potent nitrotriazole-based antitrypanosomal agents: In vitro and in vivo evaluation.
Topics: Animals; Binding Sites; Cell Line; Chagas Disease; Disease Models, Animal; Leishmania donovani; Mice; Mice, Inbred BALB C; Nitroreductases; Parasitic Sensitivity Tests; Prodrugs; Protein Structure, Tertiary; Protozoan Proteins; Rats; Sterol 14-Demethylase; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosoma cruzi | 2015 |
In vivo efficacy of voriconazole and posaconazole therapy in a novel invertebrate model of Aspergillus fumigatus infection.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Disease Models, Animal; Larva; Lepidoptera; Microbial Sensitivity Tests; Survival Analysis; Triazoles; Voriconazole | 2015 |
Development of Novel Triazolo-Thiadiazoles from Heterogeneous "Green" Catalysis as Protein Tyrosine Phosphatase 1B Inhibitors.
Topics: Animals; Antineoplastic Agents; Benzofurans; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Caspase 3; Cell Line, Tumor; Cell Movement; Chromones; Cyclin D1; Disease Models, Animal; Dose-Response Relationship, Drug; Female; G1 Phase Cell Cycle Checkpoints; Hep G2 Cells; Human Umbilical Vein Endothelial Cells; Humans; Inhibitor of Apoptosis Proteins; Liver Neoplasms; Mice; Models, Molecular; Neoplasm Invasiveness; Neovascularization, Pathologic; Poly(ADP-ribose) Polymerases; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; STAT3 Transcription Factor; Structure-Activity Relationship; Survivin; Thiadiazoles; Triazoles | 2015 |
Role of Semen on Vaginal HIV-1 Transmission and Maraviroc Protection.
Topics: Administration, Intravaginal; Animals; Anti-HIV Agents; CD4-Positive T-Lymphocytes; Cyclohexanes; Disease Models, Animal; Female; HIV Infections; HIV-1; Humans; Male; Maraviroc; Mice; Mice, Transgenic; Semen; Triazoles; Vagina; Viral Load | 2015 |
Efficacy of Posaconazole in a Murine Model of Systemic Infection by Saprochaete capitata.
Topics: Animals; Antifungal Agents; Basidiomycota; beta-Glucans; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Immunocompromised Host; Kidney; Male; Mice, Inbred Strains; Microbial Sensitivity Tests; Mycoses; Neutropenia; Proteoglycans; Triazoles | 2015 |
Effect of Preexposure to Triazoles on Susceptibility and Virulence of Rhizopus oryzae.
Topics: Agar; Animals; Antifungal Agents; Culture Media; Disease Models, Animal; Drosophila melanogaster; Female; Fluconazole; Itraconazole; Microbial Sensitivity Tests; Mucormycosis; Rhizopus; Survival Analysis; Triazoles; Virulence; Voriconazole | 2015 |
Voriconazole and posaconazole therapy for experimental Candida lusitaniae infection.
Topics: Animals; Antifungal Agents; beta-Glucans; Candida; Candidiasis; Colony Count, Microbial; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Kidney; Male; Mice; Proteoglycans; Treatment Outcome; Triazoles; Voriconazole | 2016 |
Identification and optimisation of a series of tetrahydrobenzotriazoles as metabotropic glutamate receptor 5-selective positive allosteric modulators that improve performance in a preclinical model of cognition.
Topics: Allosteric Regulation; Animals; Antipsychotic Agents; Astrocytes; Cognition; Disease Models, Animal; Drug Evaluation, Preclinical; Half-Life; Humans; Microsomes; Rats; Receptor, Metabotropic Glutamate 5; Structure-Activity Relationship; Triazoles | 2015 |
TIMP-1 mediates TGF-β-dependent crosstalk between hepatic stellate and cancer cells via FAK signaling.
Topics: Aniline Compounds; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Communication; Cell Line, Transformed; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Models, Animal; Disease Progression; Epithelial-Mesenchymal Transition; Female; Focal Adhesion Protein-Tyrosine Kinases; Hepatic Stellate Cells; Heterografts; Humans; Liver Neoplasms; Mice; Proto-Oncogene Proteins c-akt; Signal Transduction; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta; Triazoles | 2015 |
Involvement of CCL3/CCR5 Signaling in Dorsal Root Ganglion in Remifentanil-induced Hyperalgesia in Rats.
Topics: Analgesics, Opioid; Animals; CCR5 Receptor Antagonists; Chemokine CCL3; Cyclohexanes; Disease Models, Animal; Ganglia, Spinal; Hot Temperature; Hyperalgesia; Male; Maraviroc; Piperidines; Rats, Sprague-Dawley; Receptors, CCR5; Remifentanil; RNA, Messenger; Touch; Triazoles | 2016 |
Novel oral transforming growth factor-β signaling inhibitor EW-7197 eradicates CML-initiating cells.
Topics: Aniline Compounds; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Proliferation; Disease Models, Animal; Humans; Imidazoles; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Mice, Inbred C57BL; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridazines; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Transfection; Transforming Growth Factor beta; Triazoles | 2016 |
XPO1 Inhibition Enhances Radiation Response in Preclinical Models of Rectal Cancer.
Topics: Animals; Apoptosis; Cell Line, Tumor; Combined Modality Therapy; Disease Models, Animal; Dose-Response Relationship, Drug; Exportin 1 Protein; Humans; Hydrazines; Inhibitor of Apoptosis Proteins; Karyopherins; Mice; Radiation; Radiation Tolerance; Radiation-Sensitizing Agents; Receptors, Cytoplasmic and Nuclear; Rectal Neoplasms; Triazoles; Tumor Burden; Xenograft Model Antitumor Assays | 2016 |
Synergistic Myeloma Cell Death via Novel Intracellular Activation of Caspase-10-Dependent Apoptosis by Carfilzomib and Selinexor.
Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Caspase 10; Caspase 8; Cell Line, Tumor; Disease Models, Animal; Drug Synergism; Enzyme Activation; Humans; Hydrazines; Intracellular Space; Mice; Multiple Myeloma; Oligopeptides; Proteasome Inhibitors; Triazoles; Xenograft Model Antitumor Assays | 2016 |
Mesenchymal Cancer Cell-Stroma Crosstalk Promotes Niche Activation, Epithelial Reversion, and Metastatic Colonization.
Topics: Animals; Axl Receptor Tyrosine Kinase; Benzocycloheptenes; Breast Neoplasms; CD24 Antigen; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Epithelial-Mesenchymal Transition; Female; Homeodomain Proteins; Humans; Lung Neoplasms; Mice; Mice, Nude; Mice, Transgenic; Neoplasm Metastasis; Neoplastic Stem Cells; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; RNA Interference; Signal Transduction; Smad Proteins; Thrombospondins; Transforming Growth Factor beta; Transplantation, Heterologous; Triazoles | 2015 |
Single administration of a novel γ-secretase modulator ameliorates cognitive dysfunction in aged C57BL/6J mice.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Animals; Cognition; Cognition Disorders; Disease Models, Animal; Hippocampus; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuronal Plasticity; Neuroprotective Agents; Patch-Clamp Techniques; Pyridines; Triazoles | 2016 |
Pharmacological properties of a novel and potent γ-secretase modulator as a therapeutic option for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Brain; Cognition; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Immunoblotting; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuroprotective Agents; Pyridines; Real-Time Polymerase Chain Reaction; Triazoles | 2016 |
The Gut Microbiome Is Altered in a Letrozole-Induced Mouse Model of Polycystic Ovary Syndrome.
Topics: Animals; Diet; Disease Models, Animal; Female; Gastrointestinal Microbiome; Letrozole; Mice; Nitriles; Polycystic Ovary Syndrome; Triazoles | 2016 |
Effect of imatinib on growth of experimental endometriosis in rats.
Topics: Anastrozole; Angiogenesis Inhibitors; Animals; Aromatase Inhibitors; bcl-2-Associated X Protein; Cell Proliferation; Disease Models, Animal; Endometriosis; Endometrium; Female; Imatinib Mesylate; Nitriles; Ovarian Follicle; Peritoneal Diseases; Peritoneum; Proto-Oncogene Proteins c-kit; Rats; Transplantation, Autologous; Triazoles; Vascular Endothelial Growth Factor A | 2016 |
Endothelial Robo4 suppresses breast cancer growth and metastasis through regulation of tumor angiogenesis.
Topics: ADP-Ribosylation Factor 6; ADP-Ribosylation Factors; Animals; Breast Neoplasms; Cell Line, Tumor; Disease Models, Animal; Down-Regulation; Endothelial Cells; Female; Gene Knockout Techniques; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Neovascularization, Pathologic; Nerve Tissue Proteins; Receptors, Cell Surface; Receptors, Immunologic; Signal Transduction; Triazoles; Vascular Endothelial Growth Factor A; Zonula Occludens-1 Protein | 2016 |
Virulence and Resistance to Antifungal Therapies of Scopulariopsis Species.
Topics: Amphotericin B; Animals; Antifungal Agents; Cyclophosphamide; Disease Models, Animal; Drug Resistance, Fungal; Humans; Immunocompromised Host; Male; Mice; Mycoses; Neutropenia; Scopulariopsis; Species Specificity; Survival Analysis; Triazoles; Virulence; Voriconazole | 2016 |
Synthesis of Novel Oxazolo[4,5-b]pyridine-2-one based 1,2,3-triazoles as Glycogen Synthase Kinase-3β Inhibitors with Anti-inflammatory Potential.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Edema; Enzyme Inhibitors; Female; Glycogen Synthase Kinase 3 beta; Male; Nitric Oxide; Rats; Rats, Wistar; Triazoles | 2016 |
Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice.
Topics: Alginates; Animals; Blood Glucose; Blotting, Western; C-Peptide; Cell Culture Techniques; Cell Differentiation; Cell Transplantation; Chromatography, Liquid; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Models, Animal; Embryonic Stem Cells; Flow Cytometry; Fluorescent Antibody Technique; Foreign-Body Reaction; Humans; Hydrogels; Immunocompetence; Insulin; Insulin-Secreting Cells; Mice; Microscopy, Confocal; Microscopy, Phase-Contrast; Morpholines; Polymers; Tandem Mass Spectrometry; Triazoles | 2016 |
Posaconazole, a Second-Generation Triazole Antifungal Drug, Inhibits the Hedgehog Signaling Pathway and Progression of Basal Cell Carcinoma.
Topics: Animals; Antifungal Agents; Antineoplastic Agents; Carcinoma, Basal Cell; Cell Line, Tumor; Disease Models, Animal; Gene Knockout Techniques; Hedgehog Proteins; Humans; Mice; Signal Transduction; Skin Neoplasms; Smoothened Receptor; Triazoles; Xenograft Model Antitumor Assays | 2016 |
[Investigation of Prophylactic Efficacy of Triazavirin Against Experimental Forest- Spring Encephalitis on Albino Mice].
Topics: Animals; Azoles; Brain; Cell Line; Disease Models, Animal; Encephalitis, Tick-Borne; Mice; Swine; Triazines; Triazoles | 2015 |
Antidyskinetic effect of A2A and 5HT1A/1B receptor ligands in two animal models of Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Behavior, Animal; Disease Models, Animal; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Female; Levodopa; Macaca fascicularis; Male; Parkinson Disease; Piperazines; Pyrimidines; Rats; Rats, Sprague-Dawley; Serotonin Receptor Agonists; Triazoles | 2016 |
The Bromodomain BET Inhibitor JQ1 Suppresses Tumor Angiogenesis in Models of Childhood Sarcoma.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Azepines; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Child; Disease Models, Animal; Drug Resistance, Neoplasm; Human Umbilical Vein Endothelial Cells; Humans; Mice; Neovascularization, Pathologic; Proto-Oncogene Proteins c-myc; Sarcoma; Transcription Factor AP-1; Triazoles; Xenograft Model Antitumor Assays | 2016 |
Source memory in rats is impaired by an NMDA receptor antagonist but not by PSD95-nNOS protein-protein interaction inhibitors.
Topics: Aminosalicylic Acids; Animals; Benzylamines; Cells, Cultured; Chlorophenols; Cyclic GMP; Disease Models, Animal; Disks Large Homolog 4 Protein; Dizocilpine Maleate; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Hippocampus; Intracellular Signaling Peptides and Proteins; Male; Maze Learning; Membrane Proteins; Memory Disorders; N-Methylaspartate; Neurons; Nitric Oxide Synthase Type I; Rats; Rats, Long-Evans; Triazoles | 2016 |
[Effects of compound malt pills on expressions of ERα and ERβ in ovaries of rats with letrozole-induced polycystic ovarian syndrome].
Topics: Animals; Corpus Luteum; Disease Models, Animal; Drugs, Chinese Herbal; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Granulosa Cells; Letrozole; Nitriles; Ovarian Follicle; Polycystic Ovary Syndrome; Rats; Rats, Sprague-Dawley; Triazoles | 2016 |
The Effect of A2A Receptor Antagonist on Microglial Activation in Experimental Glaucoma.
Topics: Adenosine A2 Receptor Antagonists; Animals; Blotting, Western; Cell Count; Cells, Cultured; Chronic Disease; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Glaucoma; Immunohistochemistry; Intravitreal Injections; Male; Microglia; Ocular Hypertension; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Retinal Ganglion Cells; RNA; Triazines; Triazoles | 2016 |
Inhibition of late Na+ current, a novel target to improve diastolic function and electrical abnormalities in Dahl salt-sensitive rats.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Dose-Response Relationship, Drug; Heart Conduction System; Heart Failure; Heart Rate; Hypertrophy, Left Ventricular; Male; Myocardial Contraction; Myocytes, Cardiac; Oxidative Stress; Pyridines; Rats, Inbred Dahl; Sodium Channel Blockers; Sodium Channels; Sodium Chloride, Dietary; Time Factors; Triazoles; Ventricular Dysfunction, Left; Ventricular Function, Left | 2016 |
BET inhibition represses miR17-92 to drive BIM-initiated apoptosis of normal and transformed hematopoietic cells.
Topics: Animals; Apoptosis; Azepines; Bcl-2-Like Protein 11; Cell Cycle Proteins; Cell Line; Cell Line, Transformed; Disease Models, Animal; Hematopoietic System; History, Ancient; Humans; Lymphoma; Mice; Mice, Transgenic; MicroRNAs; Nuclear Proteins; RNA, Long Noncoding; Transcription Factors; Triazoles | 2016 |
Aromatase inhibitors augment nociceptive behaviors in rats and enhance the excitability of sensory neurons.
Topics: Adenosine Triphosphate; Androstadienes; Animals; Aromatase Inhibitors; Calcitonin Gene-Related Peptide; Cells, Cultured; Disease Models, Animal; Female; Ganglia, Spinal; Hyperalgesia; Hypesthesia; Letrozole; Male; Membrane Potentials; Nitriles; Nociception; Ovariectomy; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Spinal Cord; Triazoles | 2016 |
The BET-Bromodomain Inhibitor JQ1 Reduces Inflammation and Tau Phosphorylation at Ser396 in the Brain of the 3xTg Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents; Azepines; Brain; Disease Models, Animal; Drug Evaluation, Preclinical; Inflammation; Learning; Male; Memory; Mice, Transgenic; Neuroprotective Agents; Organ Size; Peptide Fragments; Phosphorylation; Spleen; tau Proteins; Triazoles | 2016 |
Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity.
Topics: Animals; Antimalarials; Dihydroorotate Dehydrogenase; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Malaria, Falciparum; Mice; Mice, SCID; Molecular Structure; Oxidoreductases Acting on CH-CH Group Donors; Parasitic Sensitivity Tests; Plasmodium falciparum; Pyrimidines; Rats; Structure-Activity Relationship; Triazoles | 2016 |
Guanosine may increase absence epileptic activity by means of A2A adenosine receptors in Wistar Albino Glaxo Rijswijk rats.
Topics: Adenosine A2 Receptor Antagonists; Animals; Anticonvulsants; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy, Absence; Fourier Analysis; Guanosine; Indomethacin; Lipopolysaccharides; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, Wistar; Receptor, Adenosine A2A; Theophylline; Time Factors; Triazoles | 2016 |
BET and BRAF inhibitors act synergistically against BRAF-mutant melanoma.
Topics: Animals; Antineoplastic Agents; Apoptosis; Azepines; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Drug Resistance, Neoplasm; Drug Synergism; Humans; Indoles; Melanoma; Mutation; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Sulfonamides; Transcription, Genetic; Triazoles; Vemurafenib; Xenograft Model Antitumor Assays | 2016 |
Keap1-Independent Regulation of Nrf2 Activity by Protein Acetylation and a BET Bromodomain Protein.
Topics: Acetylation; Animals; Azepines; Disease Models, Animal; Drosophila melanogaster; Drosophila Proteins; Humans; Kelch-Like ECH-Associated Protein 1; NF-E2-Related Factor 2; Nuclear Proteins; Oxidative Stress; Proteolysis; Repressor Proteins; Transcription Factors; Triazoles | 2016 |
In Silico Analysis Guides Selection of BET Inhibitors for Triple-Negative Breast Cancer Treatment.
Topics: Animals; Antineoplastic Agents; Apoptosis; Azepines; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Computational Biology; Datasets as Topic; Disease Models, Animal; Drug Discovery; Drug Screening Assays, Antitumor; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genome-Wide Association Study; Humans; Mice; Transcription Factors; Triazoles; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays | 2016 |
Altered motility of plaque-associated microglia in a model of Alzheimer's disease.
Topics: Adenosine A2 Receptor Antagonists; Alzheimer Disease; Animals; Cell Movement; Disease Models, Animal; Hippocampus; Humans; Immunohistochemistry; Mice, Transgenic; Microglia; Microscopy, Confocal; Neuroimmunomodulation; Plaque, Amyloid; Pyrimidines; Receptor, Adenosine A2A; Tissue Culture Techniques; Triazoles | 2016 |
The BET inhibitor JQ1 selectively impairs tumour response to hypoxia and downregulates CA9 and angiogenesis in triple negative breast cancer.
Topics: Animals; Azepines; Carbonic Anhydrase IX; Cell Line, Tumor; Cluster Analysis; Disease Models, Animal; Female; Gene Expression Profiling; High-Throughput Nucleotide Sequencing; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Neovascularization, Pathologic; Promoter Regions, Genetic; Protein Binding; Spheroids, Cellular; Transcriptome; Triazoles; Triple Negative Breast Neoplasms; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays | 2017 |
Early synaptic deficits in the APP/PS1 mouse model of Alzheimer's disease involve neuronal adenosine A2A receptors.
Topics: Adenosine A2 Receptor Antagonists; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; CA3 Region, Hippocampal; Dendritic Spines; Disease Models, Animal; Gene Expression Regulation; Humans; Long-Term Potentiation; Memory, Episodic; Mice; Mice, Transgenic; Neuroprotective Agents; Presenilin-1; Pyrimidines; Receptor, Adenosine A2A; Receptors, N-Methyl-D-Aspartate; RNA, Small Interfering; Signal Transduction; Synapses; Triazines; Triazoles | 2016 |
Isavuconazole Is Effective for the Treatment of Experimental Cryptococcal Meningitis.
Topics: Animals; Antifungal Agents; Brain; Cryptococcus neoformans; Disease Models, Animal; Meningitis, Cryptococcal; Mice; Microbial Sensitivity Tests; Nitriles; Pyridines; Triazoles | 2016 |
Anticonvulsant effect of a ghrelin receptor agonist in 6Hz corneally kindled mice.
Topics: Animals; Anticonvulsants; Cornea; Disease Models, Animal; Electric Stimulation; Glycine; Indoles; Kindling, Neurologic; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oligopeptides; Receptors, Ghrelin; Status Epilepticus; Triazoles; Tryptophan | 2016 |
Recombinant Gas6 augments Axl and facilitates immune restoration in an intracerebral hemorrhage mouse model.
Topics: Administration, Intranasal; Animals; Axl Receptor Tyrosine Kinase; Behavior, Animal; Benzocycloheptenes; Cerebral Hemorrhage; Cytokines; Disease Models, Animal; Immunity, Innate; Intercellular Signaling Peptides and Proteins; Male; Mice, Inbred Strains; Mice, Knockout; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Recombinant Proteins; Triazoles | 2017 |
A combination of an iron chelator with an antioxidant effectively diminishes the dendritic loss, tau-hyperphosphorylation, amyloids-β accumulation and brain mitochondrial dynamic disruption in rats with chronic iron-overload.
Topics: Acetylcysteine; Amyloid beta-Peptides; Animals; Antioxidants; Apoptosis; Benzoates; Brain; Deferasirox; Deferoxamine; Dendrites; Diet; Disease Models, Animal; Drug Therapy, Combination; Iron; Iron Chelating Agents; Iron Overload; Male; Mitochondrial Dynamics; Neurodegenerative Diseases; Phosphorylation; Random Allocation; Rats, Wistar; tau Proteins; Triazoles | 2016 |
BET Inhibition Induces Apoptosis in Aggressive B-Cell Lymphoma via Epigenetic Regulation of BCL-2 Family Members.
Topics: Animals; Apoptosis; Azepines; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Disease Progression; Drug Resistance, Neoplasm; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Genes, myc; Humans; Lymphoma, B-Cell; Mice; Multigene Family; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins p21(ras); Signal Transduction; Triazoles; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2016 |
Effects of Exercise Intervention on Preventing Letrozole-Exposed Rats From Polycystic Ovary Syndrome.
Topics: Animals; Aromatase Inhibitors; Body Weight; Disease Models, Animal; Female; Follicle Stimulating Hormone; Insulin; Leptin; Letrozole; Nitriles; Obesity; Physical Conditioning, Animal; Polycystic Ovary Syndrome; Progesterone; Rats; Testosterone; Triazoles | 2017 |
Preliminary characterization of a murine model for 1-bromopropane neurotoxicity: Role of cytochrome P450.
Topics: Animals; Atmosphere Exposure Chambers; Cerebral Cortex; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Disease Models, Animal; Dose-Response Relationship, Drug; Endoplasmic Reticulum Chaperone BiP; Heat-Shock Proteins; Hydrocarbons, Brominated; Injections, Intraperitoneal; Injections, Subcutaneous; Liver; Male; Mice, Inbred C57BL; Nerve Tissue Proteins; Neurons; Neurotoxicity Syndromes; Organ Size; ran GTP-Binding Protein; Solvents; Triazoles | 2016 |
Inhibition of Bromodomain and Extraterminal Domain Family Proteins Ameliorates Experimental Renal Damage.
Topics: Animals; Azepines; Chromosomal Proteins, Non-Histone; Disease Models, Animal; Kidney Diseases; Male; Mice; Mice, Inbred C57BL; Nuclear Proteins; Transcription Factors; Triazoles | 2017 |
Dipeptidyl peptidase-4 inhibitor improved exercise capacity and mitochondrial biogenesis in mice with heart failure via activation of glucagon-like peptide-1 receptor signalling.
Topics: Animals; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Exenatide; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Male; Mice, Inbred C57BL; Mitochondria; Muscle, Skeletal; Myocardial Infarction; Organelle Biogenesis; Peptides; Triazoles; Venoms | 2016 |
Effects of cisplatin and letrozole on surgically induced endometriosis and comparison of the two medications in a rat model.
Topics: Animals; Cisplatin; Disease Models, Animal; Endometriosis; Female; Letrozole; Nitriles; Rats; Triazoles | 2016 |
Highly specific blockade of CCR5 inhibits leukocyte trafficking and reduces mucosal inflammation in murine colitis.
Topics: Animals; CD11b Antigen; CD4-Positive T-Lymphocytes; Chemokine CCL5; Chemokines; Colitis; Colon; Cyclohexanes; Dextran Sulfate; Disease Models, Animal; Homeodomain Proteins; Inflammation; Intestinal Mucosa; Leukocytes; Maraviroc; Mice; Mice, Inbred C57BL; Mice, Knockout; Th17 Cells; Triazoles; Trinitrobenzenesulfonic Acid; Up-Regulation | 2016 |
Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness.
Topics: Animals; Chagas Disease; Chymotrypsin; Disease Models, Animal; Female; Humans; Inhibitory Concentration 50; Kinetoplastida; Leishmaniasis; Mice; Molecular Structure; Molecular Targeted Therapy; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrimidines; Species Specificity; Triazoles; Trypanosomiasis, African | 2016 |
Inhibition of BET bromodomain attenuates angiotensin II induced abdominal aortic aneurysm in ApoE
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Azepines; Cells, Cultured; Disease Models, Animal; Extracellular Matrix; Female; Gene Expression Regulation; Humans; Male; Metalloproteases; Mice; Mice, Inbred C57BL; Middle Aged; Reverse Transcriptase Polymerase Chain Reaction; RNA; Triazoles | 2016 |
Inhibition of BET bromodomain improves anemia in APC
Topics: Adenomatous Polyposis Coli Protein; Anemia; Animals; Azepines; Disease Models, Animal; Erythrocyte Indices; Hematocrit; Mice; Mice, Transgenic; Mutation; Nuclear Proteins; Triazoles | 2017 |
Equilibrative nucleoside transporter ENT1 as a biomarker of Huntington disease.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Biomarkers; Corpus Striatum; Disease Models, Animal; Gene Expression Regulation; Humans; Huntingtin Protein; Huntington Disease; Locomotion; Nucleoside Transport Proteins; Prefrontal Cortex; Psychomotor Disorders; Purines; Rats; Rats, Transgenic; Receptor, Adenosine A2A; Triazines; Triazoles; Trinucleotide Repeat Expansion; Tritium | 2016 |
Kisspeptin mRNA expression is increased in the posterior hypothalamus in the rat model of polycystic ovary syndrome.
Topics: Animals; Disease Models, Animal; Female; Gene Expression Regulation; Humans; Hypothalamus, Posterior; Kisspeptins; Letrozole; Nitriles; Polycystic Ovary Syndrome; Rats; Rats, Wistar; RNA, Messenger; Triazoles; Up-Regulation | 2017 |
Ganetespib, an HSP90 inhibitor, kills Epstein-Barr virus (EBV)-infected B and T cells and reduces the percentage of EBV-infected cells in the blood.
Topics: Animals; B-Lymphocytes; Cell Line, Transformed; Cell Survival; Cells, Cultured; Disease Models, Animal; Epstein-Barr Virus Infections; Epstein-Barr Virus Nuclear Antigens; Female; Herpesvirus 4, Human; HSC70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Lymphocyte Count; Mice; Mice, SCID; T-Lymphocytes; Triazoles | 2017 |
Maraviroc ameliorates the increased adipose tissue macrophage recruitment induced by a high-fat diet in a mouse model of obesity.
Topics: Adipose Tissue; Animals; Anti-HIV Agents; CCR5 Receptor Antagonists; Chemokine CCL2; Cyclohexanes; Cytokines; Diet, High-Fat; Disease Models, Animal; Gene Expression Regulation; Humans; Insulin Resistance; Macrophages; Male; MAP Kinase Kinase 4; Maraviroc; Mice; Mice, Inbred C57BL; Obesity; Triazoles; Weight Gain | 2017 |
Synergistic effect of anidulafungin combined with posaconazole in experimental aspergillosis.
Topics: Anidulafungin; Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Echinocandins; Kidney; Male; Mice; Survival Analysis; Triazoles | 2017 |
Altered expression of miRNAs in the uterus from a letrozole-induced rat PCOS model.
Topics: Animals; Disease Models, Animal; Estrus; Female; Gene Expression; Humans; Letrozole; MicroRNAs; Nitriles; Ovary; Polycystic Ovary Syndrome; Pregnancy; Rats; Rats, Wistar; Signal Transduction; Triazoles; Uterus | 2017 |
Acupuncture does not ameliorate metabolic disturbances in the P450 aromatase inhibitor-induced rat model of polycystic ovary syndrome.
Topics: Acupuncture Therapy; Adipose Tissue; Animals; Aromatase; Aromatase Inhibitors; Cytochrome P-450 Enzyme System; Disease Models, Animal; Down-Regulation; Electroacupuncture; Female; Insulin Resistance; Letrozole; Lipoproteins, LDL; Locomotion; Nitriles; Polycystic Ovary Syndrome; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Triazoles; Up-Regulation | 2017 |
Alpha B-Crystallin Protects Rat Articular Chondrocytes against Casein Kinase II Inhibition-Induced Apoptosis.
Topics: alpha-Crystallin B Chain; Animals; Apigenin; Apoptosis; Benzimidazoles; Cartilage, Articular; Casein Kinase II; Chondrocytes; Cytoprotection; Disease Models, Animal; Gene Knockdown Techniques; Gene Silencing; Male; Osteoarthritis; Phenotype; Phosphorylation; Protein Transport; Rats, Sprague-Dawley; Subcellular Fractions; Triazoles | 2016 |
Trypanosoma brucei CYP51: Essentiality and Targeting Therapy in an Experimental Model.
Topics: 14-alpha Demethylase Inhibitors; Animals; Anti-Bacterial Agents; Cytokinesis; Disease Models, Animal; Doxycycline; Eflornithine; Ergosterol; Humans; Mice; Nifurtimox; Phenotype; RNA Interference; Sterol 14-Demethylase; Triazoles; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2016 |
Blood and tissue distribution of posaconazole in a rat model of invasive pulmonary aspergillosis.
Topics: Animals; Antifungal Agents; Disease Models, Animal; Female; Invasive Pulmonary Aspergillosis; Lung; Rats, Wistar; Serum; Tissue Distribution; Triazoles | 2017 |
Ameliorative effects of rutin against metabolic, biochemical and hormonal disturbances in polycystic ovary syndrome in rats.
Topics: Animals; Antioxidants; Aromatase Inhibitors; Biomarkers; Blood Glucose; Body Weights and Measures; C-Reactive Protein; Disease Models, Animal; Estrous Cycle; Female; Gonadal Hormones; Letrozole; Lipids; Metformin; Nitriles; Ovary; Oxidative Stress; Polycystic Ovary Syndrome; Rats; Reactive Oxygen Species; Rutin; Triazoles | 2016 |
Soy isoflavones exert beneficial effects on letrozole-induced rat polycystic ovary syndrome (PCOS) model through anti-androgenic mechanism.
Topics: 17-Hydroxysteroid Dehydrogenases; 3-Hydroxysteroid Dehydrogenases; Androgen Antagonists; Animals; Antioxidants; Biomarkers; Blood Glucose; Cholesterol; Disease Models, Animal; Dose-Response Relationship, Drug; Estradiol; Estrous Cycle; Female; Glycine max; Isoflavones; Letrozole; Nitriles; Ovary; Oxidative Stress; Phytoestrogens; Phytotherapy; Plants, Medicinal; Polycystic Ovary Syndrome; Rats, Sprague-Dawley; Testosterone; Time Factors; Triazoles; Uterus; Weight Gain | 2017 |
Mechanism of Bushen Jianpi decoction in preventing and treating osteoporosis caused by aromatase inhibitors in breast cancer treatment.
Topics: Alendronate; Alkaline Phosphatase; Anastrozole; Animals; Aromatase Inhibitors; Bone Density; Bone Density Conservation Agents; Breast Neoplasms; Disease Models, Animal; Drugs, Chinese Herbal; Female; Mice, Inbred BALB C; Nitriles; Osteoporosis; Ovariectomy; Triazoles | 2017 |
The Exportin-1 Inhibitor Selinexor Exerts Superior Antitumor Activity when Combined with T-Cell Checkpoint Inhibitors.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; B7-H1 Antigen; Cell Line, Tumor; CTLA-4 Antigen; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Exportin 1 Protein; Humans; Hydrazines; Immunomodulation; Karyopherins; Melanoma, Experimental; Mice; Neoplasms; Receptors, Cytoplasmic and Nuclear; T-Lymphocytes; Triazoles | 2017 |
Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Blotting, Western; Cell Line, Tumor; Cells, Cultured; Disease Models, Animal; Drosophila melanogaster; Drosophila Proteins; Gene Expression Profiling; Glycogen Synthase Kinase 3; Humans; Kelch-Like ECH-Associated Protein 1; Lithium Chloride; Longevity; Mice; Microscopy, Confocal; Neurons; NF-E2-Related Factor 2; Oleanolic Acid; Peptide Fragments; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; Thiadiazoles; Triazoles | 2017 |
Bromodomain inhibitors, JQ1 and I-BET 762, as potential therapies for pancreatic cancer.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Azepines; Benzodiazepines; Cell Line, Tumor; Cell Proliferation; Ceruletide; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Humans; Inflammation Mediators; Macrophages; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nitric Oxide; Pancreatic Neoplasms; Pancreatitis; Phosphorylation; Proto-Oncogene Proteins c-myc; RAW 264.7 Cells; Signal Transduction; Triazoles | 2017 |
Prophylaxis with Isavuconazole or Posaconazole Protects Immunosuppressed Mice from Pulmonary Mucormycosis.
Topics: Animals; Antibiotic Prophylaxis; Antifungal Agents; Disease Models, Animal; Immunosuppression Therapy; Lung Diseases, Fungal; Mice; Mucormycosis; Nitriles; Pyridines; Rhizopus; Triazoles; Voriconazole | 2017 |
The role of nesfatin-1 expression in letrozole-induced polycystic ovaries in the rat.
Topics: Animals; Calcium-Binding Proteins; Disease Models, Animal; DNA-Binding Proteins; Female; Letrozole; Nerve Tissue Proteins; Nitriles; Nucleobindins; Ovary; Polycystic Ovary Syndrome; Random Allocation; Rats, Sprague-Dawley; Triazoles | 2017 |
Dysregulation of BET proteins in levodopa-induced dyskinesia.
Topics: Animals; Antiparkinson Agents; Azepines; Chromatin Immunoprecipitation; Corpus Striatum; Disease Models, Animal; Dyskinesia, Drug-Induced; Levodopa; Male; Oxidopamine; Parkinsonian Disorders; Protein Domains; Proteins; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; RNA, Messenger; Transcription, Genetic; Triazoles | 2017 |
Inosine attenuates spontaneous activity in the rat neurogenic bladder through an A
Topics: Adenosine A2 Receptor Antagonists; Animals; Disease Models, Animal; Humans; Inosine; Potassium Channels; Rats; Receptor, Adenosine A2A; Spinal Cord Injuries; Sulfonamides; Triazines; Triazoles; Urinary Bladder, Neurogenic; Urinary Bladder, Overactive; Xanthines | 2017 |
Ganetespib synergizes with cyclophosphamide to improve survival of mice with autochthonous tumors in a mutant p53-dependent manner.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Cyclophosphamide; Disease Models, Animal; Drug Synergism; HSP90 Heat-Shock Proteins; Lymphoma; Mice; Triazoles; Tumor Suppressor Protein p53 | 2017 |
Design, synthesis, and evaluation of fused heterocyclic analogs of SCH 58261 as adenosine A2A receptor antagonists.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Administration, Oral; Animals; Area Under Curve; Chemistry, Pharmaceutical; Disease Models, Animal; Drug Design; Hydrogen-Ion Concentration; Models, Chemical; Parkinson Disease; Pyrimidines; Rats; Solubility; Triazoles; Water | 2008 |
Characterization of angiotensin II antagonism displayed by Ib, a novel nonpeptide angiotensin AT(1) receptor antagonist.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pressure; Cattle; Cerebellum; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension; Injections, Intravenous; Liver; Losartan; Male; Protein Binding; Pyrroles; Rabbits; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Time Factors; Triazoles; Vasoconstriction | 2008 |
Adenosine A2A receptor antagonism increases nNOS-immunoreactive neurons in the striatum of Huntington transgenic mice.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Corpus Striatum; Cytoprotection; Disease Models, Animal; Enzyme Activation; Huntington Disease; Interneurons; Male; Mice; Mice, Transgenic; Neuroprotective Agents; Nitrergic Neurons; Nitric Oxide; Nitric Oxide Synthase Type I; Pyrimidines; Receptor, Adenosine A2A; Triazoles; Up-Regulation | 2008 |
The effects of adenosine A2A receptor antagonists on haloperidol-induced movement disorders in primates.
Topics: Adenosine A2 Receptor Antagonists; Animals; Antipsychotic Agents; Caffeine; Catalepsy; Cebus; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; gamma-Aminobutyric Acid; Globus Pallidus; Haloperidol; Neurologic Examination; Purines; Pyrimidines; Receptor, Adenosine A2A; Saimiri; Triazoles; Xanthines | 2008 |
Efficacy of a nanocochleate-encapsulated 3,5-diaryl-s-triazole derivative in a murine model of graft-versus-host disease.
Topics: Administration, Oral; Anemia; Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chemokines; Disease Models, Animal; Drug Compounding; Female; Graft vs Host Disease; Hematologic Tests; Immunosuppressive Agents; Mice; Mice, Inbred C57BL; Nanocapsules; Time Factors; Triazoles | 2008 |
Posaconazole combined with amphotericin B, an effective therapy for a murine disseminated infection caused by Rhizopus oryzae.
Topics: Amphotericin B; Animals; Antifungal Agents; Colony Count, Microbial; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Humans; Male; Mice; Mucormycosis; Rhizopus; Triazoles | 2008 |
Effect of platelet-activating factor antagonist WEB 2086 on microcirculatory disorders in acute experimental pancreatitis of graded severity.
Topics: Amylases; Animals; Azepines; Capillaries; Cell Adhesion; Ceruletide; Disease Models, Animal; Edema; Female; Glycodeoxycholic Acid; Leukocytes; Microcirculation; Oligopeptides; Pancreas; Pancreatitis; Pancreatitis, Acute Necrotizing; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Regional Blood Flow; Severity of Illness Index; Taurocholic Acid; Time Factors; Triazoles | 2009 |
Demonstration of the metabolic pathway responsible for nevirapine-induced skin rash.
Topics: Animals; Chromatography, Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Exanthema; Female; Male; Microsomes, Liver; Molecular Structure; Nevirapine; Oxidation-Reduction; Rats; Rats, Inbred BN; Rats, Inbred Lew; Sensitivity and Specificity; Skin; Stereoisomerism; Tandem Mass Spectrometry; Triazoles | 2008 |
Safety and efficacy of combined chelation therapy with deferasirox and deferoxamine in a gerbil model of iron overload.
Topics: Animals; Benzoates; Deferasirox; Deferoxamine; Disease Models, Animal; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Gerbillinae; Heart; Iron Overload; Liver; Organ Size; Treatment Outcome; Triazoles | 2008 |
Effects of 17beta-estradiol on rat urinary bladder: gender differences in anoxia-glucopenia and reperfusion damage.
Topics: Anastrozole; Animals; Aromatase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Estradiol; Estrogen Antagonists; Female; Fulvestrant; Glucose; Hypoxia; In Vitro Techniques; Injections, Subcutaneous; Male; Muscle Contraction; Neuroprotective Agents; Nitriles; Rats; Rats, Wistar; Reperfusion Injury; Sex Factors; Testosterone; Time Factors; Triazoles; Urinary Bladder; Urinary Bladder Diseases | 2009 |
Combined antifungal therapy in a murine model of disseminated infection by Cladophialophora bantiana.
Topics: Amphotericin B; Animals; Antifungal Agents; Ascomycota; Disease Models, Animal; Drug Therapy, Combination; Echinocandins; Flucytosine; Humans; Lipopeptides; Male; Micafungin; Mice; Mycoses; Treatment Outcome; Triazoles | 2009 |
Comparative study on the efficacy of liposomal amphotericin B and voriconazole in a murine pulmonary aspergillosis model.
Topics: Amphotericin B; Animals; Antifungal Agents; Aspergillus fumigatus; Disease Models, Animal; Lung; Male; Mice; Pulmonary Aspergillosis; Pyrimidines; Triazoles; Voriconazole | 2009 |
Effects of double and triple combinations of antifungal drugs in a murine model of disseminated infection by Scedosporium prolificans.
Topics: Amphotericin B; Animals; Antifungal Agents; Brain; Disease Models, Animal; Drug Resistance, Fungal; Drug Therapy, Combination; Echinocandins; Humans; Kidney; Lipopeptides; Male; Micafungin; Mice; Microbial Sensitivity Tests; Mycetoma; Pyrimidines; Scedosporium; Treatment Outcome; Triazoles; Voriconazole | 2009 |
Additive action of 11beta-HSD1 inhibition and PPAR-gamma agonism on hepatic steatosis and triglyceridemia in diet-induced obese rats.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Adiponectin; Animals; Disease Models, Animal; Fatty Liver; Male; Obesity; PPAR gamma; Rats; Rats, Sprague-Dawley; Receptors, Adiponectin; Rosiglitazone; Thiazolidinediones; Triazoles; Triglycerides | 2009 |
Deferasirox reduces iron overload in a murine model of juvenile hemochromatosis.
Topics: Animals; Benzoates; Deferasirox; Disease Models, Animal; Drug Evaluation, Preclinical; GPI-Linked Proteins; Hemochromatosis; Hemochromatosis Protein; Humans; Iron; Iron Chelating Agents; Magnetic Resonance Imaging; Membrane Proteins; Mice; Mice, Knockout; Organ Specificity; Triazoles | 2009 |
Combination therapy of advanced invasive pulmonary aspergillosis in transiently neutropenic rats using human pharmacokinetic equivalent doses of voriconazole and anidulafungin.
Topics: Anidulafungin; Animals; Antifungal Agents; Area Under Curve; Aspergillus fumigatus; Disease Models, Animal; Drug Therapy, Combination; Echinocandins; Female; Humans; Invasive Pulmonary Aspergillosis; Microbial Sensitivity Tests; Neutropenia; Pyrimidines; Rats; Treatment Outcome; Triazoles; Voriconazole | 2009 |
Adenosine receptor antagonists improve short-term object-recognition ability of spontaneously hypertensive rats: a rodent model of attention-deficit hyperactivity disorder.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Attention Deficit Disorder with Hyperactivity; Blood Pressure; Caffeine; Disease Models, Animal; Female; Male; Memory, Short-Term; Methylphenidate; Rats; Rats, Inbred SHR; Rats, Wistar; Receptor, Adenosine A1; Receptors, Adenosine A2; Recognition, Psychology; Triazines; Triazoles; Xanthines | 2009 |
Characterization of the potent and highly selective A2A receptor antagonists preladenant and SCH 412348 [7-[2-[4-2,4-difluorophenyl]-1-piperazinyl]ethyl]-2-(2-furanyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine] in rodent models of movement
Topics: Adenosine A2 Receptor Antagonists; Animals; CHO Cells; Cricetinae; Cricetulus; Depressive Disorder; Disease Models, Animal; Humans; Male; Mice; Movement Disorders; Neuroprotective Agents; Pyrimidines; Rats; Receptor, Adenosine A2A; Triazoles | 2009 |
The effects of caspofungin and voriconazole in an experimental fungal infection of the ear due to Aspergillus.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Caspofungin; Cyclophosphamide; Disease Models, Animal; Echinocandins; Immunocompromised Host; Immunosuppressive Agents; Lipopeptides; Otitis Media; Pyrimidines; Rabbits; Triamcinolone Acetonide; Triazoles; Voriconazole | 2009 |
Increased virulence of Zygomycetes organisms following exposure to voriconazole: a study involving fly and murine models of zygomycosis.
Topics: Amphotericin B; Animals; Antifungal Agents; Aspergillus fumigatus; Disease Models, Animal; Drosophila; Fungi; Humans; Itraconazole; Mice; Mucor; Pyrimidines; Rhizopus; Triazoles; Virulence; Voriconazole; Zygomycosis | 2009 |
Beneficial endocrine but adverse exocrine effects of sitagliptin in the human islet amyloid polypeptide transgenic rat model of type 2 diabetes: interactions with metformin.
Topics: Amyloid; Animals; Animals, Genetically Modified; Arginine; Diabetes Mellitus, Type 2; Disease Models, Animal; Glucose Clamp Technique; Humans; Hyperglycemia; Hyperinsulinism; Hypoglycemic Agents; Islet Amyloid Polypeptide; Islets of Langerhans; Metformin; Pyrazines; Rats; Rats, Sprague-Dawley; Sitagliptin Phosphate; Triazoles | 2009 |
The role of PGE2 receptor EP4 in pathologic ocular angiogenesis.
Topics: Animals; Animals, Newborn; Cell Proliferation; Choroid; Choroidal Neovascularization; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Humans; Laser Coagulation; Male; Mice; Neuroglia; Oxygen; Rats; Rats, Inbred BN; Rats, Sprague-Dawley; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; Retinal Neovascularization; Retinal Vessels; Thiophenes; Triazoles; Vascular Endothelial Growth Factor A | 2009 |
Anidulafungin treatment of candidal central nervous system infection in a murine model.
Topics: Amphotericin B; Anidulafungin; Animals; Antifungal Agents; Candida albicans; Candidiasis; Central Nervous System Infections; Disease Models, Animal; Echinocandins; Female; Mice; Pyrimidines; Triazoles; Voriconazole | 2009 |
[Basing approximate safe level of exposure to Triazavirin in air of workplace].
Topics: Air Pollutants, Occupational; Animals; Azoles; Disease Models, Animal; Maximum Tolerated Dose; Mice; Occupational Diseases; Prognosis; Rats; Risk Factors; Triazines; Triazoles | 2009 |
Efficacy of voriconazole in Japanese quail (Coturnix japonica) experimentally infected with Aspergillus fumigatus.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Coturnix; Disease Models, Animal; Female; Histocytochemistry; Lung; Male; Microbial Sensitivity Tests; Pyrimidines; Statistics, Nonparametric; Triazoles; Voriconazole | 2010 |
Cannabidiol ameliorates cognitive and motor impairments in mice with bile duct ligation.
Topics: Adenosine A2 Receptor Antagonists; Animals; Bile Ducts; Brain-Derived Neurotrophic Factor; Cannabidiol; Chronic Disease; Cognition; Cognition Disorders; Cyclooxygenase 2; Disease Models, Animal; Female; Gait Disorders, Neurologic; Hepatic Encephalopathy; Ligation; Liver Diseases; Mice; Mice, Inbred Strains; Motor Activity; Receptor, Adenosine A2A; Receptors, Tumor Necrosis Factor, Type I; RNA, Messenger; Treatment Outcome; Triazines; Triazoles | 2009 |
Differential effects of adenosine antagonists in two models of parkinsonian tremor.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Cholinergic Agonists; Disease Models, Animal; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Drug Synergism; Jaw; Male; Parkinsonian Disorders; Pimozide; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, Sprague-Dawley; Tacrine; Theophylline; Tremor; Triazoles | 2009 |
The antiangiogenic agent ZD4190 prevents tumour outgrowth in a model of minimal residual carcinoma in deep tissues.
Topics: Angiogenesis Inhibitors; Animals; Disease Models, Animal; Female; Mice; Mice, Inbred C57BL; Neoplasm, Residual; Neoplasms, Experimental; Quinazolines; Triazoles; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2009 |
Targeting retinal and choroid neovascularization using the small molecule inhibitor carboxyamidotriazole.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Animals; Antineoplastic Agents; beta-Cyclodextrins; Bromodeoxyuridine; Cell Proliferation; Cells, Cultured; Choroidal Neovascularization; Collagen; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Electroretinography; Epithelial Cells; Female; Humans; Injections, Intraocular; Laminin; Mice; Proteoglycans; Rabbits; Rats; Retina; Retinal Neovascularization; Retinal Vessels; Triazoles | 2010 |
Clozapine and quetiapine acutely reduce glucagon-like peptide-1 production and increase glucagon release in obese rats: implications for glucose metabolism and food choice behaviour.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Body Composition; Body Weight; Clozapine; Dibenzothiazepines; Dietary Fats; Disease Models, Animal; Eating; Exenatide; Food Preferences; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Tolerance Test; Hypoglycemic Agents; Insulin Resistance; Male; Obesity; Peptides; Pyrazines; Quetiapine Fumarate; Rats; Rats, Sprague-Dawley; Sitagliptin Phosphate; Triazoles; Venoms | 2009 |
Disruption in the expression and immunolocalisation of steroid receptors and steroidogenic enzymes in letrozole-induced polycystic ovaries in rat.
Topics: 3-Hydroxysteroid Dehydrogenases; Animals; Aromatase; Blotting, Western; Diestrus; Disease Models, Animal; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Follicle Stimulating Hormone; Immunohistochemistry; Letrozole; Luteinizing Hormone; Nitriles; Ovary; Phosphoproteins; Polycystic Ovary Syndrome; Proestrus; Progesterone; Rats; Rats, Wistar; Receptors, Androgen; Receptors, Progesterone; Receptors, Steroid; Testosterone; Triazoles | 2009 |
Altered distribution and function of A2A adenosine receptors in the brain of WAG/Rij rats with genetic absence epilepsy, before and after appearance of the disease.
Topics: Adenosine; Age Factors; Analysis of Variance; Animals; Blotting, Western; Disease Models, Animal; Disease Progression; Electroencephalography; Epilepsy, Absence; Glutamic Acid; Immunohistochemistry; Male; MAP Kinase Signaling System; Microinjections; Phenethylamines; Pyrimidines; Rats; Receptor, Adenosine A2A; Somatosensory Cortex; Thalamus; Triazoles | 2009 |
Disruption of nNOS-PSD95 protein-protein interaction inhibits acute thermal hyperalgesia and chronic mechanical allodynia in rodents.
Topics: Animals; Chlorophenols; Cyclic GMP; Disease Models, Animal; Disks Large Homolog 4 Protein; Guanylate Kinases; Hyperalgesia; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Mice; Mice, Inbred ICR; Neuralgia; Nitric Oxide Synthase Type I; Pain Threshold; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; tat Gene Products, Human Immunodeficiency Virus; Triazoles | 2009 |
Pharmacological modifications of the stretch-induced effects on ventricular fibrillation in perfused rabbit hearts.
Topics: Action Potentials; Adenosine A2 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Calcium Signaling; Disease Models, Animal; Electrophysiologic Techniques, Cardiac; Fourier Analysis; Heart Conduction System; In Vitro Techniques; Muscle Spindles; Myocardium; Perfusion; Propranolol; Pyrimidines; Rabbits; Receptors, Adenosine A2; Sodium-Calcium Exchanger; Thiourea; Time Factors; Triazoles; Ventricular Fibrillation | 2009 |
The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA alpha5 inverse agonists for the treatment of cognitive dysfunction.
Topics: Animals; Anticonvulsants; Benzodiazepines; Cell Line; Cognition Disorders; Disease Models, Animal; Drug Discovery; Drug Inverse Agonism; GABA-A Receptor Agonists; Humans; Imidazoles; Mice; Protein Binding; Rats; Receptors, GABA-A; Seizures; Structure-Activity Relationship; Triazoles | 2009 |
Remodeling of striatal NMDA receptors by chronic A(2A) receptor blockade in Huntington's disease mice.
Topics: Adenosine A2 Receptor Antagonists; Animals; Brain-Derived Neurotrophic Factor; Central Nervous System Agents; Corpus Striatum; Disease Models, Animal; Female; Huntington Disease; In Vitro Techniques; Male; Mice; Mice, Transgenic; N-Methylaspartate; Neuronal Plasticity; Neurotoxins; Pyrimidines; Receptor, Adenosine A2A; Receptor, trkB; Receptors, N-Methyl-D-Aspartate; Triazoles | 2010 |
Therapeutic efficacy of posaconazole against Candida glabrata in a murine model of vaginitis.
Topics: Animals; Antifungal Agents; Candida glabrata; Candidiasis; Disease Models, Animal; Female; Humans; Mice; Mice, Inbred BALB C; Random Allocation; Triazoles; Vaginitis | 2011 |
Inactivation of neuronal forebrain A receptors protects dopaminergic neurons in a mouse model of Parkinson's disease.
Topics: Adenosine A2 Receptor Antagonists; Animals; CD11b Antigen; Corpus Striatum; Disease Models, Animal; Dopamine; Glial Fibrillary Acidic Protein; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; MPTP Poisoning; Nerve Tissue Proteins; Neuroglia; Neurons; Neuroprotective Agents; Prosencephalon; Pyrimidines; Receptors, Adenosine A2; Substantia Nigra; Triazoles; Tyrosine 3-Monooxygenase | 2009 |
Effect of aromatase inhibitors on ectopic endometrial growth and peritoneal environment in a mouse model of endometriosis.
Topics: Anastrozole; Animals; Apoptosis; Aromatase; Aromatase Inhibitors; Ascitic Fluid; Cell Proliferation; Disease Models, Animal; Endometriosis; Endometrium; Female; Letrozole; Mice; Nitriles; Prostaglandins E; Triazoles; Vascular Endothelial Growth Factor A | 2010 |
Caffeine and an adenosine A(2A) receptor antagonist prevent memory impairment and synaptotoxicity in adult rats triggered by a convulsive episode in early life.
Topics: Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Animals, Newborn; Caffeine; Disease Models, Animal; Disease Progression; Drug Administration Schedule; Glial Fibrillary Acidic Protein; Kainic Acid; Memory Disorders; Neurotoxicity Syndromes; Phosphodiesterase Inhibitors; Purines; Pyrimidines; Qa-SNARE Proteins; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures; Synapses; Synaptophysin; Synaptosomal-Associated Protein 25; Triazoles; Tritium; Xanthines | 2010 |
Efficacy of posaconazole against three clinical Aspergillus fumigatus isolates with mutations in the cyp51A gene.
Topics: Administration, Oral; Animals; Antifungal Agents; Area Under Curve; Aspergillosis; Aspergillus fumigatus; Cytochrome P-450 Enzyme System; Disease Models, Animal; Drug Administration Schedule; Female; Fungal Proteins; Mice; Microbial Sensitivity Tests; Mutation; Triazoles | 2010 |
Synthesis and antiprotozoal activity of cationic 1,4-diphenyl-1H-1,2,3-triazoles.
Topics: Amidines; Animals; Antiprotozoal Agents; Cell Line; Cell Survival; Disease Models, Animal; Female; Leishmania donovani; Mice; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Rats; Stereoisomerism; Structure-Activity Relationship; Triazoles; Trypanosoma brucei rhodesiense | 2010 |
A new ethyladenine antagonist of adenosine A(2A) receptors: behavioral and biochemical characterization as an antiparkinsonian drug.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adenine; Animals; Antiparkinson Agents; Autoradiography; Behavior, Animal; Brain Chemistry; CD11b Antigen; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Early Growth Response Protein 1; Gene Expression Regulation; Jaw; Levodopa; Male; Mice; Mice, Inbred C57BL; Motor Activity; Movement; Nerve Degeneration; Nerve Tissue Proteins; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Psychomotor Performance; Pyrimidines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Rotarod Performance Test; Time Factors; Triazoles; Vibrissae | 2010 |
Oral tremor induced by the muscarinic agonist pilocarpine is suppressed by the adenosine A2A antagonists MSX-3 and SCH58261, but not the adenosine A1 antagonist DPCPX.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Jaw; Male; Muscarinic Agonists; Pilocarpine; Pimozide; Pyrimidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Tremor; Triazoles; Xanthines | 2010 |
Evaluation of antifungal therapy in a neutropenic murine model of Neoscytalidium dimidiatum infection.
Topics: Amphotericin B; Animals; Antifungal Agents; Ascomycota; Colony Count, Microbial; Disease Models, Animal; Kidney; Male; Mice; Mycoses; Neutropenia; Pyrimidines; Sepsis; Spleen; Survival Analysis; Treatment Outcome; Triazoles; Voriconazole | 2010 |
Murine model of a disseminated infection by the novel fungus Fonsecaea monophora and successful treatment with posaconazole.
Topics: Animals; Antifungal Agents; Ascomycota; Brain; Disease Models, Animal; Kidney; Liver; Lung; Male; Mice; Mycoses; Triazoles | 2010 |
Efficacy of posaconazole as treatment and prophylaxis against Fusarium solani.
Topics: Animals; Antifungal Agents; Chemoprevention; Disease Models, Animal; Drug Resistance, Fungal; Fusarium; Humans; Kidney; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Mycoses; Neutropenia; Treatment Outcome; Triazoles | 2010 |
Synthesis and anticonvulsant activity of a new 6-alkoxy-[1,2,4]triazolo[4,3-b]pyridazine.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Mice; Molecular Structure; Motor Activity; Pyridazines; Rotarod Performance Test; Seizures; Stereoisomerism; Structure-Activity Relationship; Triazoles | 2010 |
Understanding resistance to endocrine agents: molecular mechanisms and potential for intervention.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Hormonal; Aromatase; Breast Neoplasms; Cell Line, Tumor; Disease Models, Animal; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Female; Humans; Letrozole; Mice; Mice, Nude; Neoplasms, Hormone-Dependent; Nitriles; Ovariectomy; Receptor, ErbB-2; Signal Transduction; Transfection; Trastuzumab; Triazoles; Xenograft Model Antitumor Assays | 2010 |
The effects of metformin and letrozole on endometriosis and comparison of the two treatment agents in a rat model.
Topics: Animals; Aromatase Inhibitors; Disease Models, Animal; Endometriosis; Female; Hypoglycemic Agents; Letrozole; Metformin; Nitriles; Omentum; Peritoneal Diseases; Rats; Rats, Wistar; Tissue Adhesions; Triazoles | 2010 |
Correlation between in vitro activity of posaconazole and in vivo efficacy against Rhizopus oryzae infection in mice.
Topics: Animals; Antifungal Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance, Fungal; In Vitro Techniques; Kaplan-Meier Estimate; Kidney; Mice; Mucormycosis; Rhizopus; Triazoles | 2010 |
Cutaneous model of invasive aspergillosis.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Catalase; Cyclophosphamide; Dermatomycoses; Disease Models, Animal; Female; Galactose; Hyphae; Immunocompromised Host; Immunosuppressive Agents; Mannans; Mice; Mice, Inbred BALB C; Mice, Nude; Mutagenesis; Skin; Spores; Triazoles; Virulence; Virulence Factors | 2010 |
Acadesine inhibits tissue factor induction and thrombus formation by activating the phosphoinositide 3-kinase/Akt signaling pathway.
Topics: Adenosine A2 Receptor Antagonists; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Apolipoproteins E; Atherosclerosis; Blood Coagulation; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Activation; Fibrinolytic Agents; Humans; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Monocytes; NF-kappa B; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrazoles; Pyrimidines; Receptor, Adenosine A2A; Ribonucleosides; RNA, Messenger; Sepsis; Signal Transduction; Thromboplastin; Transcription Factor AP-1; Triazines; Triazoles; Up-Regulation; Venous Thrombosis | 2010 |
Comparison of the effects of raloxifene and anastrozole on experimental endometriosis.
Topics: Anastrozole; Animals; Aromatase Inhibitors; Disease Models, Animal; Endometriosis; Female; Nitriles; Raloxifene Hydrochloride; Random Allocation; Rats; Rats, Wistar; Single-Blind Method; Triazoles | 2010 |
Antiviral properties, metabolism, and pharmacokinetics of a novel azolo-1,2,4-triazine-derived inhibitor of influenza A and B virus replication.
Topics: Animals; Antiviral Agents; Azoles; Disease Models, Animal; Dogs; Drug Design; Hepatocytes; Humans; Influenza A virus; Influenza B virus; Injections, Intravenous; Kidney; Mice; Mice, Inbred CBA; Orthomyxoviridae Infections; Rabbits; Stomach; Triazines; Triazoles; Virus Replication | 2010 |
A comparative study of posaconazole and benznidazole in the prevention of heart damage and promotion of trypanocidal immune response in a murine model of Chagas disease.
Topics: Animals; Antiprotozoal Agents; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chagas Cardiomyopathy; Chagas Disease; Disease Models, Animal; Female; Heart; Humans; Mice; Myocardium; Nitroimidazoles; Survival Analysis; Triazoles; Trypanosoma cruzi | 2010 |
AfMkk2 is required for cell wall integrity signaling, adhesion, and full virulence of the human pathogen Aspergillus fumigatus.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Cell Adhesion; Cell Wall; Disease Models, Animal; Glass; Humans; Hydrogen-Ion Concentration; Mice; Mitogen-Activated Protein Kinase Kinases; Plastics; Pyrimidines; Signal Transduction; Survival Analysis; Temperature; Triazoles; Virulence; Virulence Factors; Voriconazole | 2010 |
Effects of sitagliptin treatment on dysmetabolism, inflammation, and oxidative stress in an animal model of type 2 diabetes (ZDF rat).
Topics: Animals; Blood Glucose; Blood Pressure; Body Weight; C-Reactive Protein; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Glycated Hemoglobin; Insulin; Insulin Resistance; Interleukin-1beta; Lipids; Male; Oxidative Stress; Pancreas; Pyrazines; Rats; Sitagliptin Phosphate; Triazoles | 2010 |
Preladenant, a selective A(2A) receptor antagonist, is active in primate models of movement disorders.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Area Under Curve; Basal Ganglia; Basal Ganglia Diseases; Cebus; Disease Models, Animal; Female; Macaca fascicularis; Male; Motor Activity; Pyrimidines; Receptor, Adenosine A2A; Triazoles | 2010 |
In vitro and in vivo activities of posaconazole against zygomycetes with various degrees of susceptibility.
Topics: Amphotericin B; Animals; Antifungal Agents; Child; Disease Models, Animal; Humans; Male; Mice; Microbial Sensitivity Tests; Microbial Viability; Mucorales; Rhizopus; Survival Analysis; Tetrazolium Salts; Treatment Outcome; Triazoles; Zygomycosis | 2010 |
Removal of thallium by deferasirox in rats as biological model.
Topics: Animals; Benzoates; Body Weight; Chelating Agents; Chelation Therapy; Deferasirox; Disease Models, Animal; Dose-Response Relationship, Drug; Heavy Metal Poisoning; Iron; Male; Metals, Heavy; Poisoning; Random Allocation; Rats; Rats, Wistar; Spectrophotometry, Atomic; Thallium; Triazoles | 2011 |
Design, synthesis, and biological evaluation of 1,5-diaryl-1,2,4-triazole derivatives as selective cyclooxygenase-2 inhibitors.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Celecoxib; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Drug Design; Inflammation; Inhibitory Concentration 50; Male; Mice; Protein Binding; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfonamides; Triazoles | 2010 |
Ticlopidine-induced hepatotoxicity in a GSH-depleted rat model.
Topics: Animals; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Enzyme Inhibitors; Glutathione; Platelet Aggregation Inhibitors; Protein Binding; Rats; Ticlopidine; Triazoles | 2011 |
Discovery of highly potent and efficacious MC4R agonists with spiroindane N-Me-1,2,4-triazole privileged structures for the treatment of obesity.
Topics: Animals; Chromatography, High Pressure Liquid; Disease Models, Animal; Mice; Mice, Knockout; Molecular Structure; Obesity; Rats; Receptor, Melanocortin, Type 4; Structure-Activity Relationship; Triazoles | 2010 |
Nociceptive behaviors were induced by electrical stimulation of the dura mater surrounding the superior sagittal sinus in conscious adult rats and reduced by morphine and rizatriptan benzoate.
Topics: Animals; Disease Models, Animal; Dura Mater; Electric Stimulation; Grooming; Male; Morphine; Narcotics; Pain; Rats; Rats, Sprague-Dawley; Serotonin Receptor Agonists; Superior Sagittal Sinus; Treatment Outcome; Triazoles; Tryptamines; Wakefulness | 2011 |
Combination efficacy of voriconazole and amphotericin B in the experimental disease in immunodeficient mice caused by fluconazole-resistant Cryptococcus neoformans.
Topics: Amphotericin B; Animals; Antifungal Agents; Brain; Colony Count, Microbial; Cryptococcosis; Cryptococcus neoformans; Disease Models, Animal; Drug Resistance, Fungal; Drug Therapy, Combination; Fluconazole; Lung; Mice; Mice, Inbred BALB C; Mice, SCID; Pyrimidines; Rodent Diseases; Survival Analysis; Treatment Outcome; Triazoles; Voriconazole; Yeasts | 2011 |
Comparison of aromatase inhibitor (letrozole) and immunomodulators (infliximab and etanercept) on the regression of endometriotic implants in a rat model.
Topics: Animals; Antibodies, Monoclonal; Aromatase Inhibitors; Ascitic Fluid; Disease Models, Animal; Endometriosis; Etanercept; Female; Immunoglobulin G; Immunologic Factors; Infliximab; Letrozole; Nitriles; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Tumor Necrosis Factor; Triazoles; Vascular Endothelial Growth Factor A | 2011 |
Antifungal activity of posaconazole and granulocyte colony-stimulating factor in the treatment of disseminated zygomycosis (mucormycosis) in a neutropaenic murine model.
Topics: Animal Structures; Animals; Colony Count, Microbial; Disease Models, Animal; Granulocyte Colony-Stimulating Factor; Humans; Male; Mice; Mice, Inbred BALB C; Neutropenia; Rhizopus; Rodent Diseases; Treatment Outcome; Triazoles; Zygomycosis | 2011 |
Contribution of adenosine A(2A) and A(2B) receptors to ischemic coronary dilation: role of K(V) and K(ATP) channels.
Topics: 4-Aminopyridine; Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Coronary Circulation; Disease Models, Animal; Dogs; Flavins; Glyburide; Hyperemia; KATP Channels; Male; Myocardial Ischemia; Phenethylamines; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Pyrimidines; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Triazoles; Vasodilation | 2010 |
In vitro activity and in vivo efficacy of posaconazole in treatment of murine infections by different isolates of the Aspergillus terreus complex.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Male; Mice; Microbial Sensitivity Tests; Species Specificity; Treatment Outcome; Triazoles | 2011 |
A novel approach for long-term oral drug administration in animal research.
Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Protein Precursor; Anastrozole; Animal Experimentation; Animals; Antipsychotic Agents; Body Weight; Chromatography, Liquid; Disease Models, Animal; Female; Gels; Humans; Mass Spectrometry; Mice; Mice, Transgenic; Nitriles; Presenilin-1; Reproducibility of Results; tau Proteins; Triazoles | 2011 |
Oral pre-exposure prophylaxis by anti-retrovirals raltegravir and maraviroc protects against HIV-1 vaginal transmission in a humanized mouse model.
Topics: Administration, Oral; Animals; Anti-HIV Agents; Cyclohexanes; Disease Models, Animal; Female; Flow Cytometry; HIV Infections; HIV-1; Humans; Maraviroc; Mice; Mice, Transgenic; Post-Exposure Prophylaxis; Pyrrolidinones; Raltegravir Potassium; Triazoles; Vagina | 2010 |
Ghrelin receptor (GHS-R1A) antagonism suppresses both operant alcohol self-administration and high alcohol consumption in rats.
Topics: Alcohol Drinking; Alcoholism; Analysis of Variance; Animals; Central Nervous System Depressants; Choice Behavior; Conditioning, Operant; Disease Models, Animal; Ethanol; Glycine; Male; Rats; Rats, Long-Evans; Receptors, Ghrelin; Self Administration; Signal Transduction; Triazoles | 2012 |
Sitagliptin lowers glucagon and improves glucose tolerance in prediabetic obese SHROB rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Disease Models, Animal; Feeding Behavior; Glucagon; Glucagon-Like Peptide 1; Glyburide; Hypoglycemic Agents; Insulin; Insulin Secretion; Pyrazines; Rats; Sitagliptin Phosphate; Triazoles | 2011 |
Pharmacokinetics and pharmacodynamics of posaconazole for invasive pulmonary aspergillosis: clinical implications for antifungal therapy.
Topics: Animals; Antifungal Agents; Disease Models, Animal; Invasive Pulmonary Aspergillosis; Male; Mice; Models, Theoretical; Triazoles | 2011 |
Enhanced fear expression in a psychopathological mouse model of trait anxiety: pharmacological interventions.
Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Behavior, Animal; Corticosterone; Disease Models, Animal; Disease Progression; Drug Evaluation, Preclinical; Expressed Emotion; Fear; Fluorobenzenes; Male; Mice; Neurokinin-1 Receptor Antagonists; Phobic Disorders; Physical Conditioning, Animal; Piperidines; Psychopathology; Triazoles; Up-Regulation | 2011 |
Postmenopausal hypertension: role of 20-HETE.
Topics: Aging; Animals; Blood Pressure; Cytochrome P-450 CYP4A; Disease Models, Animal; Female; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Postmenopause; Rats; Rats, Inbred SHR; Triazoles | 2011 |
Adenosine A(2A) receptor activation prevents progressive kidney fibrosis in a model of immune-associated chronic inflammation.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Anti-Inflammatory Agents; Autoantibodies; Disease Models, Animal; Extracellular Matrix Proteins; Fibrosis; Glomerulonephritis; Inflammation Mediators; Kidney; Macrophages; Male; Phenethylamines; Rats; Rats, Inbred WKY; Receptor, Adenosine A2A; Severity of Illness Index; Time Factors; Triazines; Triazoles | 2011 |
A highly selective, orally active inhibitor of Janus kinase 2, CEP-33779, ablates disease in two mouse models of rheumatoid arthritis.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Blotting, Western; Disease Models, Animal; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Janus Kinase 2; Mice; Mice, Inbred DBA; Pyridines; Triazoles | 2011 |
Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice.
Topics: Animals; Antimalarials; Dihydroorotate Dehydrogenase; Disease Models, Animal; Drug Design; Drug Discovery; Enzyme Inhibitors; Humans; Malaria; Mice; Microsomes, Liver; Molecular Structure; Oxidoreductases Acting on CH-CH Group Donors; Plasmodium berghei; Plasmodium falciparum; Protein Binding; Pyrimidines; Solubility; Structure-Activity Relationship; Triazoles | 2011 |
Therapeutic and toxicologic studies in a murine model of invasive pulmonary aspergillosis.
Topics: Amphotericin B; Animals; Antifungal Agents; Aspergillus fumigatus; Caspofungin; Colony Count, Microbial; Deoxycholic Acid; Disease Models, Animal; Drug Combinations; Drug Therapy, Combination; Echinocandins; Humans; Invasive Pulmonary Aspergillosis; Lipopeptides; Male; Micafungin; Mice; Mice, Inbred DBA; Pyrimidines; Triazoles; Voriconazole | 2011 |
A diabetes drug, sitagliptin, also has a potential to prevent diabetes.
Topics: Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Glucagon; Glucagon-Like Peptide 1; Hypoglycemic Agents; Insulin; Insulin Secretion; Pyrazines; Rats; Sitagliptin Phosphate; Triazoles | 2011 |
Deferasirox protects against iron-induced hepatic injury in Mongolian gerbil.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Benzoates; Caspase 3; Chemical and Drug Induced Liver Injury; Deferasirox; Disease Models, Animal; DNA Fragmentation; Ferritins; Gerbillinae; Iron Chelating Agents; Iron Overload; Iron-Dextran Complex; Male; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Translational Research, Biomedical; Triazoles | 2011 |
Intravitreally implantable voriconazole delivery system for experimental fungal endophthalmitis.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Disease Models, Animal; Drug Delivery Systems; Drug Implants; Endophthalmitis; Eye Infections, Fungal; Female; Lactic Acid; Male; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Pyrimidines; Rabbits; Triazoles; Vitreous Body; Voriconazole | 2011 |
Inhibition of estradiol synthesis attenuates renal injury in male streptozotocin-induced diabetic rats.
Topics: Acute Kidney Injury; Albuminuria; Anastrozole; Animals; Aromatase Inhibitors; Collagen Type IV; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Estradiol; Interleukin-6; Male; Nitriles; Rats; Rats, Sprague-Dawley; Streptozocin; Testosterone; Transforming Growth Factor beta; Triazoles | 2011 |
A topical microbicide gel formulation of CCR5 antagonist maraviroc prevents HIV-1 vaginal transmission in humanized RAG-hu mice.
Topics: Animals; Anti-Infective Agents, Local; CCR5 Receptor Antagonists; CD4 Lymphocyte Count; Chemistry, Pharmaceutical; Cyclohexanes; Disease Models, Animal; DNA-Binding Proteins; Female; Gels; HIV Infections; HIV-1; Homeodomain Proteins; Humans; Maraviroc; Mice; Placebos; Triazoles; Vagina | 2011 |
Specific targeting of the GABA-A receptor α5 subtype by a selective inverse agonist restores cognitive deficits in Down syndrome mice.
Topics: Animals; Brain; Cognition Disorders; Disease Models, Animal; Down Syndrome; Drug Delivery Systems; Drug Inverse Agonism; GABA-A Receptor Agonists; Male; Maze Learning; Memory; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Phthalazines; Receptors, GABA-A; Triazoles | 2011 |
Improved outcome of islet transplantation in partially pancreatectomized diabetic mice by inhibition of dipeptidyl peptidase-4 with sitagliptin.
Topics: Animals; Apoptosis; Blood Glucose; Cell Proliferation; Diabetes Mellitus, Experimental; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Glucagon-Like Peptide 1; Insulin-Secreting Cells; Islets of Langerhans Transplantation; Male; Mice; Mice, Inbred C57BL; Pancreatectomy; Pyrazines; Sitagliptin Phosphate; Triazoles | 2011 |
[Therapeutic efficacy of Triazavirin, a novel Russian chemotherapeutic, against influenza virus A (H5N1)].
Topics: Animals; Antiviral Agents; Azoles; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Influenza A Virus, H5N1 Subtype; Influenza, Human; Lung; Mice; Russia; Triazines; Triazoles | 2011 |
Inhibition of oestrogen biosynthesis induces mild anxiety in C57BL/6J ovariectomized female mice.
Topics: Animals; Anxiety; Aromatase Inhibitors; Depression; Disease Models, Animal; Estradiol; Female; Hippocampus; Humans; Immobility Response, Tonic; Learning; Letrozole; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Motor Activity; Nitriles; Ovariectomy; Triazoles | 2011 |
Differential neuroprotection by A(1) receptor activation and A(2A) receptor inhibition following pilocarpine-induced status epilepticus.
Topics: Adenosine; Analysis of Variance; Animals; Brain; Cell Count; Disease Models, Animal; Drug Interactions; Fluoresceins; Male; Nerve Degeneration; Neuroprotective Agents; Organic Chemicals; Phenylisopropyladenosine; Pilocarpine; Pyrimidines; Rats; Rats, Wistar; Reaction Time; Receptor, Adenosine A1; Receptor, Adenosine A2A; Status Epilepticus; Triazoles | 2011 |
Depletion of autoreactive plasma cells and treatment of lupus nephritis in mice using CEP-33779, a novel, orally active, selective inhibitor of JAK2.
Topics: Administration, Oral; Animals; Antibodies, Antinuclear; Autoimmunity; Cell Separation; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Janus Kinase 2; Lupus Nephritis; Mice; Mice, Inbred MRL lpr; Plasma Cells; Pyridines; Triazoles | 2011 |
BET bromodomain inhibition as a therapeutic strategy to target c-Myc.
Topics: Animals; Antineoplastic Agents; Azepines; Benzodiazepines; Cell Line, Tumor; Disease Models, Animal; Drug Discovery; Humans; Mice; Multiple Myeloma; Nuclear Proteins; Protein Structure, Tertiary; Proto-Oncogene Proteins c-myc; Transcriptional Activation; Triazoles | 2011 |
The anti-malarial activity of bivalent imidazolium salts.
Topics: Animals; Antimalarials; Disease Models, Animal; Erythrocytes; Imidazoles; Magnetic Resonance Spectroscopy; Malaria, Falciparum; Mass Spectrometry; Mice; Plasmodium berghei; Plasmodium falciparum; Structure-Activity Relationship; Triazoles | 2011 |
Effects of aromatase inhibition versus gonadectomy on hippocampal complex amyloid pathology in triple transgenic mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Anastrozole; Animals; Aromatase Inhibitors; Disease Models, Animal; Female; Hippocampus; Male; Mice; Mice, Transgenic; Neurons; Nitriles; Orchiectomy; Ovariectomy; Plaque, Amyloid; Triazoles | 2012 |
Synthesis of some new s-alkylated 1,2,4-triazoles, their mannich bases and their biological activities.
Topics: Analgesics; Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Disease Models, Animal; Female; Ibuprofen; Male; Mannich Bases; Microbial Sensitivity Tests; Rats; Rats, Wistar; Structure-Activity Relationship; Triazoles | 2012 |
Dipeptidyl peptidase IV inhibition improves cardiorenal function in overpacing-induced heart failure.
Topics: Animals; Calmodulin; Cardiac Pacing, Artificial; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Female; Glomerular Filtration Rate; Heart Failure; Heart Rate; Hemodynamics; Interleukin-6; Natriuretic Peptide, Brain; Pyrazines; Sitagliptin Phosphate; Sodium-Calcium Exchanger; Swine; Triazoles | 2012 |
Antifungal treatment affects the laboratory diagnosis of invasive aspergillosis.
Topics: Amphotericin B; Animals; Antifungal Agents; Aspergillus fumigatus; Biomarkers; Caspofungin; Disease Models, Animal; DNA, Fungal; Early Diagnosis; Echinocandins; Galactose; Immunoenzyme Techniques; Invasive Pulmonary Aspergillosis; Lipopeptides; Mannans; Microbiological Techniques; Mycological Typing Techniques; Predictive Value of Tests; Rats; Real-Time Polymerase Chain Reaction; Time Factors; Triazoles | 2012 |
Voriconazole, combined with amphotericin B, in the treatment for pulmonary cryptococcosis caused by C. neoformans (serotype A) in mice with severe combined immunodeficiency (SCID).
Topics: Amphotericin B; Animals; Antifungal Agents; Cryptococcosis; Cryptococcus neoformans; Disease Models, Animal; Drug Therapy, Combination; Lung; Lung Diseases, Fungal; Mice; Mice, SCID; Pyrimidines; Severe Combined Immunodeficiency; Survival Analysis; Treatment Outcome; Triazoles; Voriconazole | 2012 |
Antitumor activity of chemoendocrine therapy in premenopausal and postmenopausal models with human breast cancer xenografts.
Topics: Animals; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase; Breast Neoplasms; Capecitabine; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Female; Fluorouracil; Genes, Reporter; Humans; Letrozole; Mice; Mice, Inbred BALB C; Mice, Nude; Nitriles; Postmenopause; Premenopause; Tamoxifen; Thymidine Phosphorylase; Triazoles; Xenograft Model Antitumor Assays | 2012 |
The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adenosine A2 Receptor Antagonists; Animals; Brain; Calcium Signaling; Catalepsy; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Glutamic Acid; Haloperidol; HEK293 Cells; Humans; Levodopa; Male; Monoamine Oxidase; Motor Neuron Disease; Oxidopamine; Parkinson Disease; Picolinic Acids; Protein Binding; Psychomotor Performance; Pyrimidines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reaction Time; Receptors, G-Protein-Coupled; Receptors, Metabotropic Glutamate; Substantia Nigra; Thallium; Transfection; Triazoles; Tyrosine 3-Monooxygenase | 2012 |
Effects of DPP-4 inhibitors on the heart in a rat model of uremic cardiomyopathy.
Topics: Animals; Area Under Curve; Cardiomyopathies; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Gene Expression Regulation; Glomerular Filtration Rate; Glucagon-Like Peptide 1; Heart; Humans; Kidney Failure, Chronic; Linagliptin; Myocardium; Natriuretic Peptide, Brain; Nephrectomy; Piperidines; Purines; Pyrazines; Quinazolines; Rats; Reverse Transcriptase Polymerase Chain Reaction; Sitagliptin Phosphate; Triazoles; Uracil; Uremia | 2011 |
Diabetic nephropathy amelioration by a low-dose sitagliptin in an animal model of type 2 diabetes (Zucker diabetic fatty rat).
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Insulin; Kidney Glomerulus; Lipid Peroxidation; Lipids; Male; Obesity; Pyrazines; Rats; Rats, Zucker; Sitagliptin Phosphate; Treatment Outcome; Triazoles | 2011 |
Efficacy of intrathecal administration of liposomal amphotericin B combined with voriconazole in a murine model of cryptococcal meningitis.
Topics: Amphotericin B; Animals; Antifungal Agents; Brain; Colony Count, Microbial; Cryptococcus neoformans; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Synergism; Drug Therapy, Combination; Injections, Spinal; Male; Meningitis, Cryptococcal; Mice; Pyrimidines; Triazoles; Voriconazole | 2012 |
Prophylactic efficacy of single dose pulmonary administration of amphotericin B inhalation powder in a guinea pig model of invasive pulmonary aspergillosis.
Topics: Administration, Inhalation; Amphotericin B; Animals; Antifungal Agents; Aspergillus fumigatus; Chemoprevention; Colony Count, Microbial; Cortisone; Cyclophosphamide; Disease Models, Animal; Guinea Pigs; Immunosuppressive Agents; Invasive Pulmonary Aspergillosis; Lung; Male; Pyrimidines; Survival Analysis; Triazoles; Voriconazole | 2012 |
Cannabidiol, a non-psychotropic plant-derived cannabinoid, decreases inflammation in a murine model of acute lung injury: role for the adenosine A(2A) receptor.
Topics: Acute Lung Injury; Adenosine A2 Receptor Antagonists; Animals; Anti-Inflammatory Agents; Bone Marrow Cells; Bronchoalveolar Lavage Fluid; Cannabidiol; Cannabinoids; Capillary Permeability; Chemokines; Cytokines; Disease Models, Animal; Drug Evaluation, Preclinical; Leukocytes; Male; Mice; Mice, Inbred C57BL; Peroxidase; Receptor, Adenosine A2A; Triazines; Triazoles | 2012 |
In vitro and in vivo activities of posaconazole and amphotericin B in a murine invasive infection by Mucor circinelloides: poor efficacy of posaconazole.
Topics: Amphotericin B; Animals; Antifungal Agents; Brain; Disease Models, Animal; Drug Resistance, Fungal; Kidney; Male; Mice; Microbial Sensitivity Tests; Mucor; Mucormycosis; Neutropenia; Species Specificity; Survival Rate; Treatment Failure; Triazoles | 2012 |
Combined inhibition of aromatase activity and dihydrotestosterone supplementation attenuates renal injury in male streptozotocin (STZ)-induced diabetic rats.
Topics: Albuminuria; Anastrozole; Animals; Aromatase; Aromatase Inhibitors; Collagen Type IV; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dietary Supplements; Dihydrotestosterone; Disease Models, Animal; Estrogen Receptor alpha; Incidence; Male; Nitriles; Rats; Rats, Sprague-Dawley; Receptors, Androgen; Streptozocin; Triazoles; Tumor Necrosis Factor-alpha | 2012 |
Efficacy of posaconazole in murine experimental sporotrichosis.
Topics: Administration, Oral; Amphotericin B; Animals; Antifungal Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Histocytochemistry; Liver; Male; Mice; Microbial Sensitivity Tests; Species Specificity; Sporothrix; Sporotrichosis; Survival Rate; Treatment Outcome; Triazoles | 2012 |
Therapeutic efficacy of CEP-33779, a novel selective JAK2 inhibitor, in a mouse model of colitis-induced colorectal cancer.
Topics: Animals; Cell Line, Tumor; Colitis; Colorectal Neoplasms; Disease Models, Animal; Female; Humans; Janus Kinase 2; Mice; Mice, Inbred BALB C; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Triazoles | 2012 |
A murine model of Cryptococcus gattii meningoencephalitis.
Topics: Animals; Antifungal Agents; Antigens, Fungal; Brain; Colony Count, Microbial; Cryptococcosis; Cryptococcus gattii; Cryptococcus neoformans; Disease Models, Animal; Fluconazole; Histocytochemistry; Meningoencephalitis; Mice; Mice, Inbred ICR; Survival Analysis; Triazoles | 2012 |
Suppression of bladder overactivity by adenosine A2A receptor antagonist in a rat model of Parkinson disease.
Topics: Adenosine A2 Receptor Antagonists; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Parkinson Disease; Rats; Rats, Sprague-Dawley; Triazines; Triazoles; Urinary Bladder, Overactive; Urination | 2012 |
Efficacy of posaconazole in a murine model of disseminated infection caused by Apophysomyces variabilis.
Topics: Amphotericin B; Animals; Antifungal Agents; Disease Models, Animal; Humans; Injections, Intravenous; Male; Mice; Microbial Sensitivity Tests; Mucorales; Mucormycosis; Treatment Outcome; Triazoles | 2012 |
Experimental murine model of disseminated infection by Saksenaea vasiformis: successful treatment with posaconazole.
Topics: Amphotericin B; Animals; Antifungal Agents; Disease Models, Animal; Male; Mice; Microbial Sensitivity Tests; Mucorales; Mucormycosis; Treatment Outcome; Triazoles | 2012 |
Peptides of the constant region of antibodies display fungicidal activity.
Topics: Animals; Antibodies; Antifungal Agents; Candida albicans; Candidiasis; Caspofungin; Cryptococcus neoformans; Disease Models, Animal; Drug Resistance, Fungal; Echinocandins; Erythrocytes; Female; Hemolysis; Humans; Immunoglobulin A; Immunoglobulin Constant Regions; Immunoglobulin G; Immunoglobulin M; Lipopeptides; Malassezia; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Peptides; Triazoles | 2012 |
JAK2 inhibition in murine systemic lupus erythematosus.
Topics: Animals; Disease Models, Animal; Humans; Interleukin-6; Janus Kinase 2; Kidney; Lupus Erythematosus, Systemic; Lupus Nephritis; Mice; Plasma Cells; Pyridines; Signal Transduction; Treatment Outcome; Triazoles | 2012 |
Synthesis and anticonvulsant activities of some triazolothiadiazole derivatives.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Injections, Intraperitoneal; Mice; Mice, Inbred Strains; Molecular Structure; Seizures; Thiadiazoles; Triazoles | 2012 |
A novel glycine transporter-1 (GlyT1) inhibitor, ASP2535 (4-[3-isopropyl-5-(6-phenyl-3-pyridyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole), improves cognition in animal models of cognitive impairment in schizophrenia and Alzheimer's disease.
Topics: Administration, Oral; Alzheimer Disease; Animals; Brain; Cognition Disorders; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Glycine Plasma Membrane Transport Proteins; Humans; Inhibitory Concentration 50; Male; Memory Disorders; Mice; Oxadiazoles; Permeability; Rats; Rats, Wistar; Schizophrenia; Triazoles | 2012 |
Combination of acupuncture and chinese medicinal herbs in treating model rats with polycystic ovary syndrome.
Topics: Acupuncture Therapy; Administration, Oral; Animals; Benzofurans; Chromatography, High Pressure Liquid; Disease Models, Animal; Drugs, Chinese Herbal; Enzyme-Linked Immunosorbent Assay; Female; Follicle Stimulating Hormone; Letrozole; Luteinizing Hormone; Nitriles; Polycystic Ovary Syndrome; Rats; Rats, Sprague-Dawley; Testosterone; Treatment Outcome; Triazoles | 2011 |
Characterization of fusarium keratitis outbreak isolates: contribution of biofilms to antimicrobial resistance and pathogenesis.
Topics: Amphotericin B; Animals; Antifungal Agents; Biofilms; Corneal Ulcer; Disease Models, Animal; Disease Outbreaks; Drug Resistance, Fungal; Epithelium, Corneal; Eye Infections, Fungal; Fusariosis; Fusarium; Mice; Mice, Inbred C57BL; Microbial Sensitivity Tests; Microscopy, Confocal; Natamycin; Pyrimidines; Triazoles; Virulence; Voriconazole | 2012 |
Effect of 4-(4-bromophenyl)-5-(3-chlorophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione on the anticonvulsant action of different classical antiepileptic drugs in the mouse maximal electroshock-induced seizure model.
Topics: Animals; Anticonvulsants; Avoidance Learning; Behavior, Animal; Brain; Disease Models, Animal; Drug Interactions; Electroshock; Hand Strength; Male; Memory; Mice; Motor Activity; Muscle, Skeletal; Seizures; Thiones; Triazoles | 2012 |
Sitagliptin exerts anti-inflammatory and anti-allergic effects in ovalbumin-induced murine model of allergic airway disease.
Topics: Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Inflammation; Lung; Male; Mice; Nitric Oxide Synthase Type II; Ovalbumin; Pyrazines; RNA, Messenger; Sitagliptin Phosphate; Triazoles | 2012 |
GABAB-mediated rescue of altered excitatory-inhibitory balance, gamma synchrony and behavioral deficits following constitutive NMDAR-hypofunction.
Topics: Animals; Autistic Disorder; Baclofen; Disease Models, Animal; Evoked Potentials, Auditory; Exploratory Behavior; Fluorobenzenes; GABA-B Receptor Agonists; In Situ Hybridization; Intellectual Disability; Interneurons; Male; Mice; Mice, Transgenic; Parvalbumins; Phenotype; Pyramidal Cells; Receptors, N-Methyl-D-Aspartate; Risperidone; Schizophrenia; Social Behavior; Synaptic Potentials; Triazoles | 2012 |
Successful combination: existing drugs boost cancer vaccine responses.
Topics: Animals; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Breast Neoplasms; Cancer Vaccines; Daclizumab; Disease Models, Animal; Female; Humans; Immunoglobulin G; Letrozole; Lung Neoplasms; Membrane Glycoproteins; Mice; Nitriles; Treatment Outcome; Triazoles | 2012 |
Are epidemiologic cut-off values predictors of the in vivo efficacy of azoles in experimental aspergillosis?
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus flavus; Aspergillus niger; Disease Models, Animal; Male; Mice; Microbial Sensitivity Tests; Pyrimidines; Treatment Outcome; Triazoles; Voriconazole | 2012 |
Dipeptidyl peptidase 4 inhibitor sitagliptin protects endothelial function in hypertension through a glucagon-like peptide 1-dependent mechanism.
Topics: Aged; Aged, 80 and over; Animals; Blood Pressure; Cells, Cultured; Cyclic AMP; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Endothelium, Vascular; Exenatide; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Hypertension; In Vitro Techniques; Kidney; Magnetic Resonance Imaging; Male; Middle Aged; Nitric Oxide; Peptides; Pyrazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Glucagon; Regional Blood Flow; Renal Artery; Signal Transduction; Sitagliptin Phosphate; Triazoles; Venoms | 2012 |
In vitro-in vivo correlation of voriconazole resistance due to G448S mutation (cyp51A gene) in Aspergillus fumigatus.
Topics: Animals; Antifungal Agents; Aspergillus fumigatus; Cytochrome P-450 Enzyme System; Disease Models, Animal; Drug Resistance, Fungal; Female; Fungal Proteins; Humans; Mice; Mice, Inbred ICR; Mutation, Missense; Pulmonary Aspergillosis; Pyrimidines; Treatment Outcome; Triazoles; Voriconazole | 2012 |
Phosphodiesterase III inhibition increases cAMP levels and augments the infarct size limiting effect of a DPP-4 inhibitor in mice with type-2 diabetes mellitus.
Topics: Animals; Blood Glucose; Cilostazol; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Diabetes Mellitus, Type 2; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Glucagon-Like Peptide 1; Glycated Hemoglobin; Immunoblotting; Lipids; Lipoxins; Male; Membrane Proteins; Mice; Myocardial Infarction; Myocardium; Phosphodiesterase 3 Inhibitors; PTEN Phosphohydrolase; Tetrazoles; Triazoles | 2012 |
Discovery of novel 1,2,4-triazol-5-ones as tumor necrosis factor-alpha inhibitors for the treatment of neuropathic pain.
Topics: Analgesics; Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Edema; Humans; Mice; Neuralgia; Rats; Rats, Wistar; Structure-Activity Relationship; Triazoles; Tumor Necrosis Factor-alpha | 2012 |
Evaluation of benznidazole treatment combined with nifurtimox, posaconazole or AmBisome® in mice infected with Trypanosoma cruzi strains.
Topics: Amphotericin B; Animals; Chagas Disease; Disease Models, Animal; DNA, Protozoan; Drug Therapy, Combination; Female; Mice; Mice, Inbred BALB C; Nifurtimox; Nitroimidazoles; Parasite Load; Parasitemia; Real-Time Polymerase Chain Reaction; Treatment Outcome; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2012 |
Effectiveness and molecular interactions of the clinically active mTORC1 inhibitor everolimus in combination with tamoxifen or letrozole in vitro and in vivo.
Topics: Animals; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Nucleolus; Cell Proliferation; Disease Models, Animal; Drug Resistance, Neoplasm; Everolimus; Female; Humans; Letrozole; Mechanistic Target of Rapamycin Complex 1; Mice; Multiprotein Complexes; Nitriles; Phosphorylation; Protein Kinase Inhibitors; Protein Transport; Proto-Oncogene Proteins c-akt; Receptor, ErbB-3; Receptors, Estrogen; Signal Transduction; Sirolimus; Tamoxifen; TOR Serine-Threonine Kinases; Triazoles; Xenograft Model Antitumor Assays | 2012 |
Assessment of the effects of NS11394 and L-838417, α2/3 subunit-selective GABA(A) [corrected] receptor-positive allosteric modulators, in tests for pain, anxiety, memory and motor function.
Topics: Allosteric Regulation; Analgesics; Animals; Anxiety; Benzimidazoles; Disease Models, Animal; Dose-Response Relationship, Drug; Fear; Fluorobenzenes; GABA-A Receptor Agonists; Male; Maze Learning; Memory Disorders; Motor Activity; Pain; Rats; Rats, Wistar; Receptors, GABA-A; Triazoles | 2012 |
CRM1 blockade by selective inhibitors of nuclear export attenuates kidney cancer growth.
Topics: Acrylates; Active Transport, Cell Nucleus; Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Renal Cell; Cell Line, Tumor; Disease Models, Animal; Exportin 1 Protein; Flow Cytometry; Humans; Immunoblotting; Immunohistochemistry; Karyopherins; Kidney Neoplasms; Male; Mice; Mice, Nude; Molecular Targeted Therapy; Neoplasm Transplantation; Random Allocation; Receptors, Cytoplasmic and Nuclear; Sensitivity and Specificity; Survival Rate; Triazoles; Tumor Burden | 2013 |
Pharmacodynamics of anidulafungin against clinical Aspergillus fumigatus isolates in a nonneutropenic murine model of disseminated aspergillosis.
Topics: Anidulafungin; Animals; Antifungal Agents; Area Under Curve; Aspergillosis; Aspergillus fumigatus; Cytochrome P-450 Enzyme System; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance, Bacterial; Echinocandins; Female; Fungal Proteins; Humans; Mice; Mutation; Neutrophils; Promoter Regions, Genetic; Pyrimidines; Survival Analysis; Treatment Outcome; Triazoles; Voriconazole | 2013 |
Efficacy and pharmacodynamics of voriconazole combined with anidulafungin in azole-resistant invasive aspergillosis.
Topics: Anidulafungin; Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Disease Models, Animal; Drug Resistance, Fungal; Drug Synergism; Drug Therapy, Combination; Echinocandins; Female; Mice; Pyrimidines; Survival Analysis; Treatment Outcome; Triazoles; Voriconazole | 2013 |
Posaconazole pharmacodynamic target determination against wild-type and Cyp51 mutant isolates of Aspergillus fumigatus in an in vivo model of invasive pulmonary aspergillosis.
Topics: Administration, Oral; Animals; Antifungal Agents; Area Under Curve; Aspergillus fumigatus; Colony Count, Microbial; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fungal Proteins; Humans; Immunocompromised Host; Invasive Pulmonary Aspergillosis; Lung; Mice; Microbial Sensitivity Tests; Mutation; Sterol 14-Demethylase; Survival Analysis; Triazoles | 2013 |
A genome-scale RNA-interference screen identifies RRAS signaling as a pathologic feature of Huntington's disease.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Drosophila melanogaster; Farnesyltranstransferase; Genome, Human; HEK293 Cells; Humans; Huntingtin Protein; Huntington Disease; Metabolic Networks and Pathways; Mice; Mitochondria; Mutation; Nerve Tissue Proteins; Neurons; Pyrimidines; ras Proteins; RNA Interference; Signal Transduction; Triazoles | 2012 |
Efficacy of voriconazole in a murine model of acute Trypanosoma cruzi infection.
Topics: Animal Structures; Animals; Antiprotozoal Agents; Chagas Disease; Disease Models, Animal; Female; Histocytochemistry; Mice; Mice, Inbred BALB C; Parasitemia; Pyrimidines; Survival Analysis; Triazoles; Trypanosoma cruzi; Voriconazole | 2013 |
Rufinamide attenuates mechanical allodynia in a model of neuropathic pain in the mouse and stabilizes voltage-gated sodium channel inactivated state.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Hyperalgesia; Mice; Mice, Inbred C57BL; Neuralgia; Physical Stimulation; Triazoles; Voltage-Gated Sodium Channels | 2013 |
Tacrolimus enhances the potency of posaconazole against Rhizopus oryzae in vitro and in an experimental model of mucormycosis.
Topics: Animals; Antifungal Agents; Disease Models, Animal; Drosophila; Drug Synergism; Drug Therapy, Combination; Female; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Mucormycosis; Rhizopus; Tacrolimus; Treatment Outcome; Triazoles | 2013 |
Aromatase inhibitor treatment limits progression of peritoneal endometriosis in baboons.
Topics: Animals; Aromatase; Aromatase Inhibitors; Disease Models, Animal; Disease Progression; Endometriosis; Female; Laparoscopy; Letrozole; Menstruation; Nitriles; Organ Size; Ovary; Papio anubis; Peritoneum; RNA, Messenger; Treatment Outcome; Triazoles | 2013 |
The effect of second-line antiestrogen therapy on breast tumor growth after first-line treatment with the aromatase inhibitor letrozole: long-term studies using the intratumoral aromatase postmenopausal breast cancer model.
Topics: Animals; Aromatase; Aromatase Inhibitors; Disease Models, Animal; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Female; Fulvestrant; Humans; In Vitro Techniques; Letrozole; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms, Hormone-Dependent; Nitriles; Receptors, Estrogen; Tamoxifen; Triazoles; Tumor Cells, Cultured | 2002 |
KP-103, a novel triazole derivative, is effective in preventing relapse and successfully treating experimental interdigital tinea pedis and tinea corporis in guinea pigs.
Topics: Animals; Antibiotic Prophylaxis; Antifungal Agents; Aspergillus flavus; Disease Models, Animal; Drug Evaluation, Preclinical; Guinea Pigs; Keratins; Male; Microbial Sensitivity Tests; Secondary Prevention; Tinea; Tinea Pedis; Toes; Treatment Outcome; Triazoles; Trichophyton | 2002 |
A small molecule inhibitor of redox-regulated NF-kappa B and activator protein-1 transcription blocks allergic airway inflammation in a mouse asthma model.
Topics: Administration, Intranasal; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Movement; Chemokine CCL11; Chemokines, CC; Disease Models, Animal; Eosinophils; Female; Humans; Inflammation; Interleukin-13; Lung; Mice; Mice, Inbred BALB C; Mucus; NF-kappa B; Ovalbumin; Oxidation-Reduction; Pyridazines; Thioredoxins; Transcription Factor AP-1; Triazoles; Tumor Cells, Cultured | 2002 |
In vivo pharmacodynamics of a new triazole, ravuconazole, in a murine candidiasis model.
Topics: Animals; Antifungal Agents; Area Under Curve; Candidiasis; Disease Models, Animal; Female; Humans; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Thiazoles; Triazoles | 2003 |
Improving the mouse model for studying the efficacy of voriconazole.
Topics: Animals; Beverages; Citrus paradisi; Disease Models, Animal; Fusarium; Kidney; Mice; Mice, Inbred ICR; Mycoses; Pyrimidines; Spleen; Triazoles; Voriconazole | 2003 |
Combination therapy in treatment of experimental pulmonary aspergillosis: synergistic interaction between an antifungal triazole and an echinocandin.
Topics: Animals; Aspergillosis; Aspergillus fumigatus; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Echinocandins; Female; Lipopeptides; Lipoproteins; Lung; Lung Diseases, Fungal; Micafungin; Organ Size; Peptides, Cyclic; Rabbits; Thiazoles; Triazoles | 2003 |
Synthesis and evaluation of pharmacological properties of novel annelated 2,3-benzodiazepine derivatives.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Benzodiazepines; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; In Vitro Techniques; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred DBA; Neurons; Olfactory Pathways; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Structure-Activity Relationship; Triazoles | 2003 |
The role of platelet activating factor and the efficacy of apafant ophthalmic solution in experimental allergic conjunctivitis.
Topics: Animals; Antigens; Azepines; Capillary Permeability; Conjunctivitis, Allergic; Disease Models, Animal; Dose-Response Relationship, Drug; Dye Dilution Technique; Guinea Pigs; Humans; Immunization, Passive; Ketotifen; Male; Ophthalmic Solutions; Platelet Activating Factor; Pruritus; Time Factors; Triazoles | 2003 |
In vivo pharmacokinetics and pharmacodynamics of a new triazole, voriconazole, in a murine candidiasis model.
Topics: Administration, Oral; Animals; Antifungal Agents; Area Under Curve; Candida albicans; Candidiasis; Colony Count, Microbial; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance, Fungal; Female; Fluconazole; Kidney; Mice; Microbial Sensitivity Tests; Neutropenia; Pyrimidines; Triazoles; Voriconazole | 2003 |
The intratumoral aromatase model: studies with aromatase inhibitors and antiestrogens.
Topics: Androstadienes; Animals; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Cell Line, Tumor; Disease Models, Animal; Drug Administration Schedule; Enzyme Inhibitors; Estrogen Antagonists; Female; Humans; Letrozole; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Neoplasms, Hormone-Dependent; Nitriles; Tamoxifen; Treatment Outcome; Triazoles | 2003 |
Adenosine A2A and dopamine receptor interactions in basal ganglia of dopamine denervated rats.
Topics: Adenosine A2 Receptor Antagonists; Animals; Antiparkinson Agents; Basal Ganglia; Behavior, Animal; Denervation; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Gene Expression; Glutamate Decarboxylase; Isoenzymes; Levodopa; Motor Activity; Neuroprotective Agents; Oxidopamine; Parkinsonian Disorders; Pyrimidines; Rats; Receptor, Adenosine A2A; Receptors, Dopamine; RNA, Messenger; Time; Triazoles | 2003 |
A2A receptors in neuroprotection of dopaminergic neurons.
Topics: Adenosine A2 Receptor Antagonists; Animals; Caffeine; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Male; Neurons; Neuroprotective Agents; Parkinson Disease; Purines; Pyrimidines; Receptor, Adenosine A2A; Sex Factors; Triazoles | 2003 |
Adenosine A2A receptors in neuroadaptation to repeated dopaminergic stimulation: implications for the treatment of dyskinesias in Parkinson's disease.
Topics: Adenosine A2 Receptor Antagonists; Amphetamine; Animals; Antiparkinson Agents; Behavior, Animal; Disease Models, Animal; Dopamine; Dopamine Agonists; Drug Tolerance; Dyskinesia, Drug-Induced; Humans; Levodopa; Mice; Mice, Knockout; Neurons; Neuroprotective Agents; Oxidopamine; Parkinsonian Disorders; Purines; Pyrimidines; Receptor, Adenosine A2A; Synapses; Triazoles | 2003 |
Adenosine A2A receptors and depression.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Antidepressive Agents; Behavior, Animal; Caffeine; Depression; Disease Models, Animal; Dopamine Antagonists; Drug Interactions; Haloperidol; Mice; Mice, Knockout; Motor Activity; Neurotransmitter Agents; Parkinsonian Disorders; Purines; Pyrimidines; Receptor, Adenosine A2A; Triazines; Triazoles | 2003 |
Discovery of nonxanthine adenosine A2A receptor antagonists for the treatment of Parkinson's disease.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Antiparkinson Agents; Binding, Competitive; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Drug Evaluation, Preclinical; Humans; Ligands; Mefloquine; Mice; Motor Activity; Neuroprotective Agents; Parkinsonian Disorders; Phenethylamines; Purines; Pyrimidines; Radioligand Assay; Rats; Triazines; Triazoles | 2003 |
Adenosine administration produces an antidepressant-like effect in mice: evidence for the involvement of A1 and A2A receptors.
Topics: Adenosine; Animals; Antidepressive Agents; Caffeine; Depressive Disorder; Disease Models, Animal; Female; Male; Mice; Motor Activity; Receptor, Adenosine A1; Receptor, Adenosine A2A; Stress, Psychological; Triazines; Triazoles; Xanthines | 2004 |
Multiple structural and functional abnormalities in the p450 aromatase expressing transgenic male mice are ameliorated by a p450 aromatase inhibitor.
Topics: Adrenal Glands; Animals; Aromatase; Body Weight; Cryptorchidism; Disease Models, Animal; Endocrine System Diseases; Estradiol; Gynecomastia; Humans; Immunohistochemistry; Leydig Cells; Male; Mammary Glands, Human; Mice; Mice, Transgenic; Nitriles; Pituitary Gland; Promoter Regions, Genetic; Spermatogenesis; Testosterone; Triazoles; Ubiquitin C | 2004 |
Cardiac myocytes activated by septic plasma promote neutrophil transendothelial migration: role of platelet-activating factor and the chemokines LIX and KC.
Topics: Animals; Animals, Newborn; Azepines; Cecum; Chemokine CXCL1; Chemokine CXCL5; Chemokines, CXC; Chemotaxis, Leukocyte; Cysteine Endopeptidases; Disease Models, Animal; Endothelium, Vascular; Intercellular Signaling Peptides and Proteins; Interleukin-1; Intestinal Perforation; Leupeptins; Ligation; Mice; Mice, Inbred C57BL; Mice, Knockout; Multienzyme Complexes; Myocytes, Cardiac; Neutrophils; NF-kappa B; Peritonitis; Plasma; Protease Inhibitors; Proteasome Endopeptidase Complex; Sepsis; Triazoles; Tumor Necrosis Factor-alpha | 2004 |
Therapeutic strategies using the aromatase inhibitor letrozole and tamoxifen in a breast cancer model.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Disease Models, Animal; Disease Progression; Drug Administration Schedule; Enzyme Inhibitors; Estrogen Receptor Modulators; Female; Humans; Letrozole; Linear Models; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms, Hormone-Dependent; Nitriles; Organ Size; Ovariectomy; Tamoxifen; Transplantation, Heterologous; Triazoles; Uterus | 2004 |
Interaction of loreclezole with conventional antiepileptic drugs in amygdala-kindled rats.
Topics: Amygdala; Animals; Anticonvulsants; Avoidance Learning; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Kindling, Neurologic; Male; Psychomotor Performance; Rats; Rats, Wistar; Reaction Time; Seizures; Triazoles | 2004 |
Structure-activity relationships of adenosine A3 receptor ligands: new potential therapy for the treatment of glaucoma.
Topics: Adenosine A3 Receptor Antagonists; Animals; Binding Sites; Disease Models, Animal; Drug Design; Glaucoma; Haplorhini; Ligands; Pyrimidines; Receptor, Adenosine A3; Structure-Activity Relationship; Time Factors; Triazoles | 2004 |
Effect of WEB 2170 BS, platelet activating factor receptor inhibitor, in the rabbit model of sinusitis.
Topics: Animals; Azepines; Disease Models, Animal; Maxillary Sinus; Maxillary Sinusitis; Mucous Membrane; Nitric Oxide; Nitric Oxide Synthase; Platelet Aggregation Inhibitors; Rabbits; Triazoles | 2004 |
Blockade of adenosine A2A receptors antagonizes parkinsonian tremor in the rat tacrine model by an action on specific striatal regions.
Topics: Adenosine A2 Receptor Antagonists; Animals; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Jaw; Male; Movement; Parkinsonian Disorders; Piperazines; Pyrimidines; Rats; Rats, Sprague-Dawley; Tacrine; Time Factors; Trema; Triazoles | 2004 |
Effects of the antiestrogen tamoxifen and the aromatase inhibitor letrozole on serum hormones and bone characteristics in a preclinical tumor model for breast cancer.
Topics: Animals; Antineoplastic Agents; Aromatase; Body Composition; Breast Neoplasms; Cell Division; Cell Line, Tumor; Disease Models, Animal; Female; Humans; Letrozole; Mice; Mice, Nude; Mice, Transgenic; Nitriles; Ovariectomy; Tamoxifen; Transplantation, Heterologous; Triazoles | 2004 |
Efficacy of voriconazole plus amphotericin B or micafungin in a guinea-pig model of invasive pulmonary aspergillosis.
Topics: Amphotericin B; Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Colony Count, Microbial; Disease Models, Animal; Drug Therapy, Combination; Echinocandins; Female; Guinea Pigs; Lipopeptides; Lipoproteins; Lung; Lung Diseases, Fungal; Micafungin; Peptides, Cyclic; Pyrimidines; Survival Analysis; Triazoles; Voriconazole | 2004 |
CAI is a potent inhibitor of neovascularization and imparts neuroprotection in a mouse model of ischemic retinopathy.
Topics: Angiogenesis Inhibitors; Animals; Animals, Newborn; Antineoplastic Agents; Disease Models, Animal; Fluorescein Angiography; Hyperoxia; In Situ Nick-End Labeling; Ischemia; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Neuroprotective Agents; Proto-Oncogene Proteins c-bcl-2; Retinal Neovascularization; Retinal Vessels; Triazoles | 2004 |
Novel bicyclic piperazine derivatives of triazolotriazine and triazolopyrimidines as highly potent and selective adenosine A2A receptor antagonists.
Topics: Adenosine A2 Receptor Antagonists; Administration, Oral; Animals; Catalepsy; Disease Models, Animal; Drug Stability; In Vitro Techniques; Male; Mice; Microsomes, Liver; Molecular Structure; Parkinson Disease; Piperazines; Pyrimidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship; Triazines; Triazoles | 2004 |
Hyperfunctionality of serotonin-2C receptor-mediated inhibition of accumbal dopamine release in an animal model of depression is reversed by antidepressant treatment.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Depression; Desipramine; Disease Models, Animal; Dopamine; Extracellular Space; Male; Microdialysis; Models, Animal; Nucleus Accumbens; Piperazines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Serotonin; Serotonin 5-HT2 Receptor Antagonists; Spiro Compounds; Staining and Labeling; Sulfonamides; Time Factors; Triazoles | 2005 |
Synthesis of alkyne derivatives of a novel triazolopyrazine as A(2A) adenosine receptor antagonists.
Topics: Adenosine A2 Receptor Antagonists; Administration, Oral; Alkynes; Animals; Catalepsy; Cerebral Cortex; Disease Models, Animal; Mice; Oxidopamine; Parkinson Disease; Pyrazines; Rats; Structure-Activity Relationship; Triazoles | 2005 |
Pharmacodynamic and pharmacokinetic interaction studies of loreclezole with felbamate, lamotrigine, topiramate, and oxcarbazepine in the mouse maximal electroshock seizure model.
Topics: Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Electroshock; Felbamate; Fructose; Kindling, Neurologic; Lamotrigine; Male; Mice; Motor Activity; Oxcarbazepine; Phenylcarbamates; Propylene Glycols; Seizures; Topiramate; Triazines; Triazoles | 2005 |
Comparative efficacies of TAK-187, a long-lasting ergosterol biosynthesis inhibitor, and benznidazole in preventing cardiac damage in a murine model of Chagas' disease.
Topics: Acute Disease; Animals; Chagas Cardiomyopathy; Chagas Disease; Disease Models, Animal; Ergosterol; Male; Mice; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2005 |
Synergistic inhibitory effects of gastrin and histamine receptor antagonists on Helicobacter-induced gastric cancer.
Topics: Achlorhydria; Animals; Atrophy; Benzodiazepinones; Disease Models, Animal; Gastrins; Helicobacter felis; Helicobacter Infections; Histamine H2 Antagonists; Male; Mice; Mice, Transgenic; Phenylurea Compounds; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Receptors, Histamine H2; Stomach Neoplasms; Triazoles | 2005 |
2-(2-Furanyl)-7-phenyl[1,2,4]triazolo[1,5-c]pyrimidin-5-amine analogs: highly potent, orally active, adenosine A2A antagonists. Part 1.
Topics: Adenosine A2 Receptor Antagonists; Administration, Oral; Animals; Catalepsy; Disease Models, Animal; Drug Evaluation, Preclinical; Male; Molecular Structure; Pyrimidines; Rats; Structure-Activity Relationship; Triazoles | 2005 |
2-(2-Furanyl)-7-phenyl[1,2,4]triazolo[1,5-c]pyrimidin-5-amine analogs as adenosine A2A antagonists: the successful reduction of hERG activity. Part 2.
Topics: Adenosine A2 Receptor Antagonists; Administration, Oral; Animals; Catalepsy; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Molecular Structure; Motor Activity; Pyrimidines; Rats; Structure-Activity Relationship; Triazoles | 2005 |
Modulation of seizures and synaptic plasticity by adenosinergic receptors in an experimental model of temporal lobe epilepsy induced by pilocarpine in rats.
Topics: 5'-Nucleotidase; Adenosine; Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; In Situ Nick-End Labeling; Male; Neuronal Plasticity; Neuroprotective Agents; Pilocarpine; Purinergic P1 Receptor Antagonists; Quinazolines; Rats; Rats, Wistar; Receptors, Purinergic P1; Status Epilepticus; Synapses; Triazoles; Xanthines | 2005 |
In vitro and in vivo antifungal activities of FX0685, a novel triazole antifungal agent with potent activity against fluconazole-resistant Candida albicans.
Topics: Animals; Antifungal Agents; Candida albicans; Candidiasis; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Resistance, Fungal; Fluconazole; Injections, Intravenous; Male; Mice; Mice, Inbred CBA; Mice, Inbred DBA; Microbial Sensitivity Tests; Species Specificity; Triazoles | 2005 |
11beta-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Adamantane; Animals; Aorta; Arteriosclerosis; Azepines; Blood Glucose; Cortisone; Diet, Atherogenic; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Fatty Acids; Hydrocortisone; Insulin; Insulin Resistance; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Syndrome; Triazoles; Triglycerides | 2005 |
A comparison of chlordiazepoxide, bretazenil, L838,417 and zolpidem in a validated mouse Vogel conflict test.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Benzodiazepinones; Chlordiazepoxide; Conflict, Psychological; Disease Models, Animal; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drinking Behavior; Drug Interactions; Electroshock; Fluorobenzenes; GABA Agents; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Pyridines; Reaction Time; Reproducibility of Results; Time Factors; Triazoles; Water Deprivation; Zolpidem | 2005 |
Contribution of cytochrome P450 metabolites of arachidonic acid to hypertension and end-organ damage in spontaneously hypertensive rats treated with L-NAME.
Topics: Animals; Arachidonic Acid; Blood Pressure; Blood Vessels; Collagen Type III; Coronary Vessels; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Disease Models, Animal; Enzyme Inhibitors; Hypertension; Isoproterenol; Kidney; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Norepinephrine; Proteinuria; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Splanchnic Circulation; Triazoles; Vasoconstrictor Agents; Vasodilator Agents | 2005 |
Retinal function assessed by ERG before and after induction of ocular aspergillosis and treatment by the anti-fungal, micafungin, in rabbits.
Topics: Amphotericin B; Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Disease Models, Animal; Echinocandins; Electroretinography; Endophthalmitis; Eye Infections, Fungal; Follow-Up Studies; Lipopeptides; Lipoproteins; Micafungin; Ophthalmoscopy; Peptides, Cyclic; Pyrimidines; Rabbits; Retina; Triazoles; Vitreous Body; Voriconazole | 2005 |
Comparative efficacies of conventional amphotericin b, liposomal amphotericin B (AmBisome), caspofungin, micafungin, and voriconazole alone and in combination against experimental murine central nervous system aspergillosis.
Topics: Amphotericin B; Animals; Antifungal Agents; Aspergillosis; Caspofungin; Central Nervous System Fungal Infections; Disease Models, Animal; Drug Combinations; Drug Therapy, Combination; Echinocandins; Lipopeptides; Lipoproteins; Liposomes; Micafungin; Mice; Peptides, Cyclic; Pyrimidines; Triazoles; Voriconazole | 2005 |
Aromatase inhibitors--a triumph of translational oncology.
Topics: Animals; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease Models, Animal; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Triazoles | 2005 |
A2a receptors mediate inhibitory effects of adenosine on colonic motility in the presence of experimental colitis.
Topics: Adenosine; Animals; Colitis; Disease Models, Animal; Gastrointestinal Motility; Intestinal Mucosa; Male; Muscle Contraction; Muscle, Smooth; Nitric Oxide; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Reverse Transcriptase Polymerase Chain Reaction; Sensitivity and Specificity; Tissue Culture Techniques; Triazines; Triazoles | 2006 |
The selective A2A receptor antagonist SCH 58261 protects from neurological deficit, brain damage and activation of p38 MAPK in rat focal cerebral ischemia.
Topics: Analysis of Variance; Animals; Blotting, Western; Brain; Brain Injuries; Brain Ischemia; Disease Models, Animal; Enzyme Activation; Functional Laterality; Immunohistochemistry; Male; Microscopy, Confocal; Motor Activity; Nervous System Diseases; Neurologic Examination; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Pyrimidines; Rats; Rats, Wistar; Triazoles | 2006 |
Sequential or combination antifungal therapy with voriconazole and liposomal amphotericin B in a Guinea pig model of invasive aspergillosis.
Topics: Amphotericin B; Animals; Antifungal Agents; Aspergillosis; Disease Models, Animal; Drug Therapy, Combination; Guinea Pigs; Liposomes; Male; Pyrimidines; Triazoles; Voriconazole | 2006 |
Early and transient alteration of adenosine A2A receptor signaling in a mouse model of Huntington disease.
Topics: Adenylyl Cyclases; Animals; Basal Ganglia; Cyclic AMP; Disease Models, Animal; Huntington Disease; Mice; Mice, Transgenic; Receptors, Adenosine A2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Triazines; Triazoles | 2006 |
Efficacy of voriconazole in a guinea pig model of invasive trichosporonosis.
Topics: Amphotericin B; Animals; Antifungal Agents; Colony Count, Microbial; Disease Models, Animal; Guinea Pigs; Humans; Kidney; Liver; Microbial Sensitivity Tests; Mycoses; Pyrimidines; Spleen; Survival Analysis; Triazoles; Trichosporon; Voriconazole | 2006 |
Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Disease Models, Animal; Dyslipidemias; Glipizide; Hypoglycemic Agents; Immunohistochemistry; Insulin; Insulin-Secreting Cells; Islets of Langerhans; Male; Mice; Mice, Inbred ICR; Pyrazines; Sitagliptin Phosphate; Sulfonylurea Compounds; Triazoles | 2006 |
Efficacy of Abelcet alone, or in combination therapy, against experimental central nervous system aspergillosis.
Topics: Amphotericin B; Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Brain; Central Nervous System Infections; Colony Count, Microbial; Disease Models, Animal; Drug Combinations; Drug Therapy, Combination; Kidney; Mice; Phosphatidylcholines; Phosphatidylglycerols; Pyrimidines; Survival Analysis; Triazoles; Voriconazole | 2006 |
Mouse spinal cord compression injury is reduced by either activation of the adenosine A2A receptor on bone marrow-derived cells or deletion of the A2A receptor on non-bone marrow-derived cells.
Topics: Adenosine A2 Receptor Agonists; Analysis of Variance; Animals; Bone Marrow Cells; Bone Marrow Transplantation; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Female; Mice; Mice, Knockout; Motor Activity; Myelin Sheath; Piperidines; Radioligand Assay; Receptor, Adenosine A2A; Spinal Cord Compression; Time Factors; Triazines; Triazoles | 2006 |
Dopamine and adenosine receptor interaction as basis for the treatment of Parkinson's disease.
Topics: Analysis of Variance; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Jaw; Male; Movement; Parkinson Disease; Pilocarpine; Piperazines; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Tacrine; Tremor; Triazoles | 2006 |
Adenosine A2A receptors in diffuse dermal fibrosis: pathogenic role in human dermal fibroblasts and in a murine model of scleroderma.
Topics: Animals; Cells, Cultured; Collagen; Dermis; Disease Models, Animal; Enzyme Inhibitors; Fibroblasts; Fibrosis; Gene Expression; Humans; Hydroxyproline; Male; MAP Kinase Kinase 1; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptor, Adenosine A2A; RNA, Messenger; Scleroderma, Diffuse; Triazines; Triazoles | 2006 |
Functional and cytoarchitectural spinal cord protection by ATL-146e after ischemia/reperfusion is mediated by adenosine receptor agonism.
Topics: Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Cell Survival; Cyclohexanecarboxylic Acids; Disease Models, Animal; Microtubule-Associated Proteins; Neurons; Neuroprotective Agents; Paraplegia; Purines; Rabbits; Receptor, Adenosine A2A; Reperfusion Injury; Spinal Cord; Spinal Cord Ischemia; Time Factors; Triazines; Triazoles | 2006 |
Antileishmanial activities and mechanisms of action of indole-based azoles.
Topics: Animals; Antiprotozoal Agents; Azoles; Disease Models, Animal; Dose-Response Relationship, Drug; Ergosterol; Imidazoles; Indoles; Interleukin-4; Leishmania major; Leishmania mexicana; Leishmaniasis; Liver; Male; Mice; Mice, Inbred BALB C; Microscopy, Electron, Scanning; Molecular Structure; Parasitic Sensitivity Tests; Phospholipases A; Sensitivity and Specificity; Spleen; Triazoles | 2006 |
Deficits of glutamate transmission in the striatum of experimental hemiballism.
Topics: Anesthetics, Local; Animals; Corpus Striatum; Disease Models, Animal; Dopamine Antagonists; Dyskinesias; Electric Stimulation; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Sulpiride; Synaptic Transmission; Tetrodotoxin; Triazines; Triazoles | 2006 |
Caffeine and adenosine A(2a) receptor antagonists prevent beta-amyloid (25-35)-induced cognitive deficits in mice.
Topics: Adenosine A2 Receptor Antagonists; Alzheimer Disease; Amnesia; Amyloid beta-Peptides; Animals; Avoidance Learning; Brain; Caffeine; Cognition Disorders; Disease Models, Animal; Drug Synergism; Male; Maze Learning; Mice; Neuroprotective Agents; Peptide Fragments; Phosphodiesterase Inhibitors; Pyrimidines; Receptor, Adenosine A2A; Treatment Outcome; Triazoles | 2007 |
Dissociation between vasospasm and functional improvement in a murine model of subarachnoid hemorrhage.
Topics: Animals; Antihypertensive Agents; Apolipoproteins E; Behavior, Animal; Calcium Channel Blockers; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Middle Cerebral Artery; Neurologic Examination; Nimodipine; Peptides; Reaction Time; Rotarod Performance Test; Subarachnoid Hemorrhage; Treatment Outcome; Triazoles; Vasospasm, Intracranial | 2006 |
Posaconazole prophylaxis in experimental systemic zygomycosis.
Topics: Absidia; Amphotericin B; Animals; Antibiotic Prophylaxis; Antifungal Agents; Brain; Cells, Cultured; Disease Models, Animal; Kidney; Lung; Male; Mice; Microbial Sensitivity Tests; Mucormycosis; Rhizopus; Spleen; Time Factors; Triazoles | 2007 |
The effects of atamestane and toremifene alone and in combination compared with letrozole on bone, serum lipids and the uterus in an ovariectomized rat model.
Topics: Androstenedione; Animals; Antineoplastic Combined Chemotherapy Protocols; Disease Models, Animal; Female; Humans; Letrozole; Lipids; Models, Chemical; Nitriles; Organ Size; Ovariectomy; Rats; Rats, Sprague-Dawley; Toremifene; Triazoles; Uterus | 2007 |
Comparative in vivo activity of BAL4815, the active component of the prodrug BAL8557, in a neutropenic murine model of disseminated Aspergillus flavus.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus flavus; Brain; Caspofungin; Colony Count, Microbial; Disease Models, Animal; Echinocandins; Fluorescence Resonance Energy Transfer; Immunocompromised Host; Immunosuppression Therapy; Itraconazole; Kidney; Lipopeptides; Liver; Lung; Male; Mice; Neutropenia; Nitriles; Peptides, Cyclic; Polymerase Chain Reaction; Pyrimidines; Survival Analysis; Triazoles; Voriconazole | 2006 |
Role of atypical opiates in OCD. Experimental approach through the study of 5-HT(2A/C) receptor-mediated behavior.
Topics: 5-Hydroxytryptophan; Analgesics, Opioid; Animals; Clozapine; Desipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Fluvoxamine; Indophenol; Levorphanol; Male; Methadone; Mice; Morphine; Naloxone; Narcotic Antagonists; Obsessive-Compulsive Disorder; Piperazines; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Stereotyped Behavior; Tics; Tourette Syndrome; Tramadol; Triazoles | 2007 |
Adenosine A2A receptor blockade before striatal excitotoxic lesions prevents long term behavioural disturbances in the quinolinic rat model of Huntington's disease.
Topics: Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Behavior, Animal; Behavioral Symptoms; Corpus Striatum; Disease Models, Animal; Drug Interactions; Exploratory Behavior; Huntington Disease; Male; Maze Learning; Neuroprotective Agents; Pyrimidines; Quinolinic Acid; Rats; Rats, Wistar; Receptor, Adenosine A2A; Time Factors; Triazoles | 2007 |
Effect of antifungal treatment in a murine model of blastoschizomycosis.
Topics: Amphotericin B; Animals; Antifungal Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Fluconazole; Flucytosine; Geotrichosis; Geotrichum; Immunocompromised Host; Immunosuppressive Agents; Kidney; Liver; Male; Mice; Microbial Sensitivity Tests; Pyrimidines; Spleen; Survival Analysis; Treatment Outcome; Triazoles; Voriconazole | 2007 |
Deferasirox and deferiprone remove cardiac iron in the iron-overloaded gerbil.
Topics: Animals; Benzoates; Deferasirox; Deferiprone; Disease Models, Animal; Female; Gerbillinae; Heart; Iron; Iron Chelating Agents; Iron Overload; Liver; Organ Size; Pyridones; Triazoles | 2006 |
Impact of aromatase inhibitors on adhesion formation in a rat model.
Topics: Anastrozole; Animals; Aromatase Inhibitors; Cytokines; Disease Models, Animal; Female; Medroxyprogesterone Acetate; Nitriles; Postoperative Complications; Rats; Rats, Wistar; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Tissue Adhesions; Triazoles; Uterine Diseases; Uterus | 2007 |
The novel adenosine A2a antagonist ST1535 potentiates the effects of a threshold dose of l-dopa in unilaterally 6-OHDA-lesioned rats.
Topics: Adenine; Adenosine; Adenosine A2 Receptor Antagonists; Animals; Brain; Disease Models, Animal; Dopamine Agents; Dose-Response Relationship, Drug; Drug Synergism; Exploratory Behavior; Levodopa; Male; Movement; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; Receptor, Adenosine A2A; Sympatholytics; Triazoles | 2007 |
Combined use of WEB2170 and HBO therapy can reduce ischemia and reperfusion injury to the skeletal muscle in a rabbit model.
Topics: Animals; Azepines; Combined Modality Therapy; Disease Models, Animal; Hyperbaric Oxygenation; Muscle, Skeletal; Peroxidase; Platelet Aggregation Inhibitors; Rabbits; Reperfusion Injury; Triazoles | 2007 |
Increase in [11C]vorozole binding to aromatase in the hypothalamus in rats treated with anabolic androgenic steroids.
Topics: Androgens; Animals; Aromatase; Aromatase Inhibitors; Autoradiography; Carbon Radioisotopes; Disease Models, Animal; Hypothalamus; Male; Nandrolone; Positron-Emission Tomography; Rats; Rats, Sprague-Dawley; Septal Nuclei; Substance-Related Disorders; Triazoles | 2007 |
Synergistic effects of adenosine A2A antagonist and L-DOPA on rotational behaviors in 6-hydroxydopamine-induced hemi-Parkinsonian mouse model.
Topics: Adenosine A2 Receptor Antagonists; Adrenergic Agents; Animals; Antiparkinson Agents; Behavior, Animal; Disease Models, Animal; Drug Synergism; Levodopa; Male; Mice; Mice, Inbred ICR; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Pyrimidines; Receptor, Adenosine A2A; Rotation; Triazoles | 2007 |
The role of adenosine A2a receptors in experimental acute pancreatitis.
Topics: Acute Disease; Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Amylases; Animals; Disease Models, Animal; Immunohistochemistry; Lipase; Male; Pancreas; Pancreatitis; Phenethylamines; Rats; Rats, Wistar; Receptor, Adenosine A2A; Taurocholic Acid; Triazines; Triazoles | 2006 |
The effects of caspofungin and voriconazole in experimental Candida endophthalmitis.
Topics: Amphotericin B; Animals; Antifungal Agents; Candida albicans; Candidiasis; Caspofungin; Colony Count, Microbial; Cornea; Disease Models, Animal; Echinocandins; Endophthalmitis; Eye Infections, Fungal; Itraconazole; Lipopeptides; Peptides, Cyclic; Pyrimidines; Rabbits; Triazoles; Voriconazole | 2007 |
Discovery of novel indazole-linked triazoles as antifungal agents.
Topics: Administration, Oral; Animals; Antifungal Agents; Aspergillus; Candida; Disease Models, Animal; Indazoles; Mice; Microbial Sensitivity Tests; Rats; Stereoisomerism; Triazoles | 2007 |
Combined therapies in a murine model of blastoschizomycosis.
Topics: Amphotericin B; Animals; Antifungal Agents; Colony Count, Microbial; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Echinocandins; Flucytosine; Geotrichosis; Geotrichum; Humans; Immunocompromised Host; Lipopeptides; Lipoproteins; Male; Micafungin; Mice; Mice, Inbred Strains; Microbial Sensitivity Tests; Mycoses; Peptides, Cyclic; Pyrimidines; Survival Analysis; Triazoles; Trichosporon; Voriconazole | 2007 |
Therapeutic efficacy of posaconazole against isolates of Candida albicans with different susceptibilities to fluconazole in a vaginal model.
Topics: Animals; Antifungal Agents; Candida albicans; Candidiasis, Vulvovaginal; Colony Count, Microbial; Disease Models, Animal; Drug Resistance, Fungal; Female; Fluconazole; Humans; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Triazoles; Vagina | 2007 |
Efficacy of voriconazole in a murine model of cryptococcal central nervous system infection.
Topics: Animals; Antifungal Agents; Brain; Central Nervous System Fungal Infections; Cryptococcosis; Cryptococcus neoformans; Disease Models, Animal; Humans; Lung; Male; Mice; Pyrimidines; Treatment Outcome; Triazoles; Voriconazole | 2007 |
Effects of the adenosine A2A receptor antagonist SCH 58621 on cyclooxygenase-2 expression, glial activation, and brain-derived neurotrophic factor availability in a rat model of striatal neurodegeneration.
Topics: Adenosine A2 Receptor Antagonists; Animals; Brain-Derived Neurotrophic Factor; Corpus Striatum; Cyclooxygenase 2; Disease Models, Animal; Drug Interactions; Free Radicals; Gene Expression Regulation; Male; Neurodegenerative Diseases; Neuroglia; Prostaglandins; Pyrimidines; Quinolinic Acid; Rats; Rats, Wistar; Triazoles | 2007 |
A new rat model exhibiting both ovarian and metabolic characteristics of polycystic ovary syndrome.
Topics: Adipocytes; Androgens; Animals; Aromatase Inhibitors; Body Composition; Body Weight; Dihydrotestosterone; Disease Models, Animal; Estrous Cycle; Female; Letrozole; Magnetic Resonance Imaging; Mesentery; Muscle, Skeletal; Nitriles; Organ Size; Ovary; Polycystic Ovary Syndrome; Rats; Rats, Wistar; Testosterone; Triazoles | 2007 |
CYP26 inhibitor R115866 increases retinoid signaling in intimal smooth muscle cells.
Topics: Analysis of Variance; Animals; Aorta, Thoracic; Benzothiazoles; Cell Proliferation; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Disease Models, Animal; Male; Muscle, Smooth, Vascular; Probability; Protein Isoforms; Rats; Rats, Sprague-Dawley; Retinoids; Reverse Transcriptase Polymerase Chain Reaction; Sensitivity and Specificity; Signal Transduction; Triazoles; Tunica Intima; Tunica Media | 2007 |
The role of adenosine A1 and A2A receptors of entorhinal cortex on piriform cortex kindled seizures in rats.
Topics: Adenosine; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Electric Stimulation; Electrodes, Implanted; Entorhinal Cortex; Kindling, Neurologic; Male; Microinjections; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptor, Adenosine A2A; Seizures; Triazines; Triazoles; Xanthines | 2007 |
New guinea pig model of Cryptococcal meningitis.
Topics: Animals; Antifungal Agents; Cerebrospinal Fluid; Colony Count, Microbial; Cryptococcus neoformans; Disease Models, Animal; Fluconazole; Guinea Pigs; Humans; Male; Meningitis, Cryptococcal; Pyrimidines; Triazoles; Voriconazole | 2007 |
Comparison of twice-daily vs once-daily deferasirox dosing in a gerbil model of iron cardiomyopathy.
Topics: Animals; Benzoates; Cardiomyopathies; Deferasirox; Disease Models, Animal; Drug Administration Schedule; Female; Gerbillinae; Iron; Iron Chelating Agents; Iron Overload; Liver; Myocardium; Triazoles | 2007 |
Pre-clinical validation of early molecular markers of sensitivity to aromatase inhibitors in a mouse model of post-menopausal hormone-sensitive breast cancer.
Topics: Animals; Aromatase Inhibitors; Biomarkers, Tumor; Biopsy, Needle; Breast Neoplasms; Cyclin D; Cyclins; Disease Models, Animal; Female; Gene Expression Regulation, Neoplastic; Ki-67 Antigen; Letrozole; Mice; Nitriles; Peptides; Postmenopause; Receptors, Estrogen; Trefoil Factor-1; Triazoles | 2008 |
Targeted deletion of A2A adenosine receptors attenuates the protective effects of myocardial postconditioning.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Disease Models, Animal; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocardial Reperfusion Injury; Myocardium; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptor, Adenosine A2A; Research Design; Signal Transduction; Time Factors; Triazines; Triazoles; Troponin I; Ventricular Function, Left; Ventricular Pressure | 2007 |
Behavioral and electrophysiological effects of the adenosine A2A receptor antagonist SCH 58261 in R6/2 Huntington's disease mice.
Topics: Adenosine A2 Receptor Antagonists; Animals; Behavior, Animal; Brain; Corpus Striatum; Disease Models, Animal; Excitatory Amino Acid Agonists; Glutamic Acid; Huntington Disease; Learning Disabilities; Maze Learning; Mental Disorders; Mice; Mice, Transgenic; Motor Activity; Neuroprotective Agents; Organ Culture Techniques; Pyrimidines; Receptor, Adenosine A2A; Triazoles | 2007 |
Efficacy of caspofungin and posaconazole in a murine model of disseminated Exophiala infection.
Topics: Amphotericin B; Animals; Antifungal Agents; Brain; Caspofungin; Disease Models, Animal; Echinocandins; Exophiala; Female; Immunocompromised Host; Kidney; Lipopeptides; Mice; Mice, Inbred ICR; Mycoses; Survival Analysis; Triazoles | 2007 |
Antifungal efficacy of voriconazole, itraconazole and amphotericin b in experimental fusarium solani keratitis.
Topics: Administration, Topical; Amphotericin B; Animals; Antifungal Agents; Colony Count, Microbial; Corneal Ulcer; Disease Models, Animal; Eye Infections, Fungal; Fusarium; Itraconazole; Mycoses; Pyrimidines; Rabbits; Treatment Outcome; Triazoles; Voriconazole | 2008 |
Functional evaluation of THIQ, a melanocortin 4 receptor agonist, in models of food intake and inflammation.
Topics: alpha-MSH; Animals; Anti-Inflammatory Agents; Body Weight; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Eating; Electron Spin Resonance Spectroscopy; Inflammation; Injections, Intraventricular; Lipopolysaccharides; Male; Mice; Mice, Inbred ICR; Nitric Oxide; Peptides, Cyclic; Rats; Rats, Wistar; Receptor, Melanocortin, Type 4; Tetrahydroisoquinolines; Triazoles | 2007 |
Anti-inflammatory and analgesic potency of carboxyamidotriazole, a tumorostatic agent.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Arthritis; Capillary Permeability; Disease Models, Animal; Edema; Female; Granuloma; Interleukin-1; Male; Mice; Mice, Inbred ICR; Pain; Pain Measurement; Rats; Rats, Wistar; Triazoles; Tumor Necrosis Factor-alpha | 2008 |
Reversal of pathological pain through specific spinal GABAA receptor subtypes.
Topics: Analgesics; Animals; Brain; Capsaicin; Chronic Disease; Diazepam; Disease Models, Animal; Fluorobenzenes; Formaldehyde; Ganglia, Spinal; Hot Temperature; Inflammation; Male; Mice; Neurons; Organ Specificity; Pain; Protein Isoforms; Protein Subunits; Rats; Rats, Wistar; Receptors, GABA-A; Spinal Cord; Triazoles | 2008 |
The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models.
Topics: Administration, Oral; Animals; Anticonvulsants; Disease Models, Animal; Injections, Intraperitoneal; Mice; Phenobarbital; Phenytoin; Rats; Rats, Sprague-Dawley; Seizures; Severity of Illness Index; Triazoles; Valproic Acid | 2008 |
Caffeine and a selective adenosine A(2B) receptor antagonist but not imidazoline receptor antagonists modulate antinociception induced by diphenyl diselenide in mice.
Topics: Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Benzene Derivatives; Benzofurans; Caffeine; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Imidazoles; Injections, Intraperitoneal; Male; Mice; Neuroprotective Agents; Organoselenium Compounds; Pain Measurement; Phosphodiesterase Inhibitors; Pyrimidines; Triazoles; Xanthines | 2008 |
Bis-aryl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Animals; Binding Sites; Disease Models, Animal; Enzyme Inhibitors; Hydrocarbons, Aromatic; Hypoglycemic Agents; Inhibitory Concentration 50; Metabolic Syndrome; Mice; Models, Chemical; Structure-Activity Relationship; Triazoles | 2008 |
4-Methyl-5-phenyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Animals; Combinatorial Chemistry Techniques; Disease Models, Animal; Enzyme Inhibitors; Humans; Mice; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Triazoles | 2008 |
Phenylcyclobutyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Administration, Oral; Animals; Combinatorial Chemistry Techniques; Cortisone; Disease Models, Animal; Enzyme Inhibitors; Humans; Hydrocortisone; Mice; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Triazoles | 2008 |
Synthesis, ligand-receptor modeling studies and pharmacological evaluation of novel 4-modified-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as potent and selective human A3 adenosine receptor antagonists.
Topics: Adenosine A3 Receptor Antagonists; Animals; Binding, Competitive; Brain Ischemia; Cattle; Cell Membrane; Cerebral Cortex; Disease Models, Animal; Humans; Hydrogen Bonding; Ligands; Models, Molecular; Protein Binding; Quinoxalines; Rats; Receptor, Adenosine A3; Rhodopsin; Structural Homology, Protein; Structure-Activity Relationship; Triazoles; Xanthines | 2008 |
Assessment of Aspergillus fumigatus burden in pulmonary tissue of guinea pigs by quantitative PCR, galactomannan enzyme immunoassay, and quantitative culture.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Base Sequence; Colony Count, Microbial; Disease Models, Animal; DNA Primers; DNA, Fungal; Galactose; Guinea Pigs; Humans; Immunoenzyme Techniques; Lung; Lung Diseases, Fungal; Male; Mannans; Mycology; Polymerase Chain Reaction; Pyrimidines; Triazoles; Voriconazole | 2008 |
Angiotensin II receptor antagonist ameliorates renal tubulointerstitial fibrosis caused by unilateral ureteral obstruction.
Topics: Actins; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Collagen; Disease Models, Animal; Enalapril; Female; Immunohistochemistry; Monocytes; Nephritis, Interstitial; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley; Renin; RNA, Messenger; Tetrazoles; Transforming Growth Factor beta; Triazoles; Ureteral Obstruction | 1995 |
Mast cell mediators and peritoneal adhesion formation in the rat.
Topics: Animals; Azepines; Disease Models, Animal; Histamine Antagonists; Leukotriene D4; Male; Mast Cells; Methysergide; Ondansetron; Peritoneal Diseases; Platelet Activating Factor; Propionates; Pyrilamine; Quinolines; Ranitidine; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Tissue Adhesions; Triazoles | 1995 |
Endothelin-1 induces neutrophil-independent vascular injury in the rat gastric microcirculation.
Topics: Animals; Azepines; Capillary Permeability; Disease Models, Animal; Endothelins; Endothelium, Vascular; Gastric Mucosa; Infusions, Intra-Arterial; Isotope Labeling; Male; Methacrylates; Neutrophils; Platelet Activating Factor; Rats; Rats, Wistar; Serum Albumin; Stomach Ulcer; Thromboxane-A Synthase; Triazoles | 1995 |
IL-4, IgE, and interferon-gamma production in pulmonary blastomycosis: comparison in mice untreated, immunized, or treated with an antifungal (SCH 39304).
Topics: Animals; Antifungal Agents; Antigens, Surface; Blastomycosis; Cells, Cultured; Disease Models, Animal; Immunization; Immunoglobulin E; Interferons; Interleukin-4; Lung; Lymph Nodes; Lymphocytes; Male; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Spleen; Thy-1 Antigens; Triazoles | 1993 |
Pharmacological actions of SDZ 218-135, a novel positive inotropic agent.
Topics: Adenosine Triphosphate; Anesthesia; Animals; Arrhythmias, Cardiac; Cardiotonic Agents; Disease Models, Animal; Electrophysiology; Female; Guinea Pigs; Heart Atria; Hemodynamics; Isometric Contraction; Male; Myocardial Contraction; Myocardial Reperfusion Injury; Ovum; Papillary Muscles; Phosphodiesterase Inhibitors; Piperazines; Potassium; Propranolol; Pyrimidinones; Rabbits; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Triazoles | 1994 |
WEB-2086 and indomethacin do not modify blood pressure fall on unclipping hypertensive rats.
Topics: Animals; Azepines; Blood Pressure; Disease Models, Animal; Hypertension, Renal; Indomethacin; Injections, Intravenous; Male; Platelet Activating Factor; Rats; Rats, Wistar; Renal Artery; Triazoles | 1994 |
[Effects of reactive oxygen species scavenger and platelet activating factor receptor antagonist on accelerated nephrotoxic nephritis].
Topics: Animals; Azepines; Disease Models, Animal; Ferric Compounds; Free Radical Scavengers; Glomerulonephritis; Luminescent Measurements; Male; Platelet Aggregation Inhibitors; Pyridines; Rabbits; Rats; Rats, Wistar; Reactive Oxygen Species; Triazoles | 1993 |
Experimental chemotherapy with combinations of ergosterol biosynthesis inhibitors in murine models of Chagas' disease.
Topics: Animals; Antifungal Agents; Chagas Disease; Disease Models, Animal; Ergosterol; Female; Ketoconazole; Mice; Naphthalenes; Terbinafine; Triazoles; Trypanocidal Agents | 1993 |
Sch 39304, a new antifungal agent: oral and topical treatment of vaginal and superficial infections.
Topics: Administration, Oral; Administration, Topical; Animals; Antifungal Agents; Candidiasis, Vulvovaginal; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Fluconazole; Guinea Pigs; Miconazole; Tinea; Triazoles | 1993 |
PAF-induced death in NMRI mice--a suitable shock model for testing new PAF receptor antagonists. Correlation with eicosanoid related substances.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Azepines; Disease Models, Animal; Diterpenes; Eicosanoids; Female; Ginkgolides; Lactones; Masoprocol; Mice; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Shock; Species Specificity; Triazoles | 1993 |
Bronchopulmonary responses to endothelin-1 in sensitized and challenged guinea-pigs: role of cyclooxygenase metabolites and platelet-activating factor.
Topics: Aerosols; Animals; Azepines; Bronchi; Disease Models, Animal; Endothelins; Glycopeptides; Guinea Pigs; Immunization; Indomethacin; Lung; Male; Neprilysin; Ovalbumin; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Respiratory Function Tests; Tetrazoles; Thienopyridines; Time Factors; Triazoles | 1993 |
Differential effects of renin-angiotensin system blockade on atherogenesis in cholesterol-fed rabbits.
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animal Feed; Animals; Arteriosclerosis; Cholesterol, Dietary; Disease Models, Animal; Dose-Response Relationship, Drug; Enalapril; Male; Rabbits; Renin-Angiotensin System; Tetrazoles; Time Factors; Triazoles | 1993 |
Effects of combined and sequential treatment with tamoxifen and the aromatase inhibitor vorozole on 7,12-dimethylbenz(a) anthracene-induced mammary carcinoma in the rat.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Androstenedione; Animals; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Carcinogens; Disease Models, Animal; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Female; Luteinizing Hormone; Mammary Neoplasms, Experimental; Ovariectomy; Progesterone; Rats; Rats, Sprague-Dawley; Tamoxifen; Triazoles | 1996 |
Protective effect of a platelet-activating factor antagonist (WEB-2086) in postischemic renal failure.
Topics: Acute Kidney Injury; Animals; Azepines; Disease Models, Animal; Diuresis; Female; Ischemia; Kidney; Kidney Function Tests; Male; Necrosis; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rabbits; Triazoles | 1996 |
Aromatization of androgens is important for skeletal maintenance of aged male rats.
Topics: Absorptiometry, Photon; Aging; Amino Acids; Analysis of Variance; Androgens; Animals; Aromatase Inhibitors; Bone Density; Bone Development; Bone Resorption; Calcium; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estrogens; Femur; Lumbar Vertebrae; Male; Orchiectomy; Osteocalcin; Osteoporosis; Rats; Rats, Wistar; Triazoles | 1996 |
Synthesis and antifungal activity of alkylthio and alkylsulfonyl derivatives of SM-8668.
Topics: Alkylation; Animals; Antifungal Agents; Aspergillosis; Candidiasis; Disease Models, Animal; Magnetic Resonance Spectroscopy; Male; Mice; Structure-Activity Relationship; Sulfur; Triazoles | 1996 |
Effects of UR-12633, a new antagonist of platelet-activating factor, in rodent models of endotoxic shock.
Topics: Analysis of Variance; Animals; Azepines; Blood Pressure; Cell Membrane; Disease Models, Animal; Escherichia coli; Hypotension; Lipopolysaccharides; Male; Mice; Piperidines; Platelet Aggregation Inhibitors; Rabbits; Rats; Rats, Sprague-Dawley; Shock, Septic; Triazoles | 1996 |
Anti-inflammatory effect of a PAF receptor antagonist and a new molecule with antiproteinase activity in an experimental model of acute urate crystal arthritis.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Azepines; C-Reactive Protein; Dinoprostone; Disease Models, Animal; Indenes; Interleukin-6; Joints; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Protease Inhibitors; Rabbits; Random Allocation; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Synovial Fluid; Thienopyridines; Triazoles; Tumor Necrosis Factor-alpha; Uric Acid | 1996 |
Involvement of PAF in postallergic propranolol-induced bronchoconstriction in guinea-pigs.
Topics: Administration, Inhalation; Adrenergic beta-Antagonists; Anesthesia, General; Animals; Antigens; Asthma; Azepines; Bronchoconstriction; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Hypersensitivity; Immunization; Inflammation Mediators; Injections, Intravenous; Male; Platelet Activating Factor; Propranolol; Respiration, Artificial; Time Factors; Triazoles | 1996 |
Comparison of voriconazole (UK-109,496) and itraconazole in prevention and treatment of Aspergillus fumigatus endocarditis in guinea pigs.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Disease Models, Animal; Dose-Response Relationship, Drug; Endocarditis; Guinea Pigs; Itraconazole; Male; Microbial Sensitivity Tests; Pyrimidines; Triazoles; Voriconazole | 1997 |
Effect of BN 50727 on pathological findings and tissue platelet activating factor levels during ileal ischemia in newborn piglets.
Topics: Animals; Animals, Newborn; Azepines; Disease Models, Animal; Enterocolitis, Pseudomembranous; Humans; Ileum; Infant, Newborn; Ischemia; Platelet Activating Factor; Swine; Thienopyridines; Triazoles; Tumor Necrosis Factor-alpha | 1996 |
Pharmacological characterisation of a new model of antigen-induced pulmonary late-phase reaction in the conscious guinea pig which uses additional polymyxin B inhalation.
Topics: Administration, Inhalation; Animals; Anti-Bacterial Agents; Antigens; Asthma; Azepines; Disease Models, Animal; Guinea Pigs; Histamine H1 Antagonists; Hypersensitivity, Delayed; Male; Ovalbumin; Polymyxin B; Pyrilamine; Triazoles | 1996 |
Experimental electroretinographic exploration of retinal ischemia: preventive use of free radical scavengers and anti-PAF agents.
Topics: Analysis of Variance; Animals; Azepines; Dark Adaptation; Disease Models, Animal; Electroretinography; Free Radical Scavengers; Ginkgo biloba; Ischemia; Plant Extracts; Platelet Aggregation Inhibitors; Random Allocation; Rats; Rats, Sprague-Dawley; Retinal Diseases; Thienopyridines; Triazoles | 1997 |
Up-regulation of platelet-activating factor receptors in lung and alveolar macrophages in the bleomycin-hamster model of pulmonary fibrosis.
Topics: Animals; Azepines; Bleomycin; Cricetinae; Disease Models, Animal; Lung; Macrophages, Alveolar; Male; Mesocricetus; Platelet Membrane Glycoproteins; Protein Binding; Pulmonary Fibrosis; Radioligand Assay; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles; Up-Regulation | 1997 |
Rizatriptan has central antinociceptive effects against durally evoked responses.
Topics: Action Potentials; Analysis of Variance; Animals; Blood-Brain Barrier; Disease Models, Animal; Dose-Response Relationship, Drug; Dura Mater; Electric Stimulation; Electrophysiology; Injections, Intravenous; Male; Microelectrodes; Migraine Disorders; Neurons; Pain; Rats; Rats, Sprague-Dawley; Serotonin Receptor Agonists; Triazoles; Trigeminal Caudal Nucleus; Tryptamines | 1997 |
The novel anti-migraine agent rizatriptan inhibits neurogenic dural vasodilation and extravasation.
Topics: Analysis of Variance; Animals; Blood Proteins; Calcitonin Gene-Related Peptide; Disease Models, Animal; Dura Mater; Electric Stimulation; Injections, Intravenous; Lethal Dose 50; Male; Meningeal Arteries; Migraine Disorders; Neuromuscular Junction; Rats; Rats, Sprague-Dawley; Serotonin Receptor Agonists; Substance P; Triazoles; Trigeminal Nuclei; Tryptamines; Vasodilation | 1997 |
Hyperglycemic damage to mitochondrial membranes during cerebral ischemia: amelioration by platelet-activating factor antagonist BN 50739.
Topics: Animals; Azepines; Blood Pressure; Brain; Disease Models, Animal; Electroencephalography; Fatty Acids, Nonesterified; Fatty Acids, Unsaturated; Femoral Artery; Hyperglycemia; Intracellular Membranes; Ischemic Attack, Transient; Lipid Peroxidation; Male; Membrane Lipids; Mitochondria; Oxygen Consumption; Phospholipids; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Reference Values; Reperfusion; Thiobarbituric Acid Reactive Substances; Time Factors; Triazoles | 1997 |
Reduction of disease causative T-cells in experimental autoimmune disease models by a new antirheumatic drug, TAK-603.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Autoimmune Diseases; CD4-CD8 Ratio; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Lymphocyte Subsets; Male; Quinolines; Rats; Rats, Inbred Lew; Spleen; T-Lymphocytes; Triazoles | 1997 |
Role of platelet activating factor, leukotrienes and polymorphs in the FMLP induced increase in microvascular leakage in rabbit trachea.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Alkylating Agents; Animals; Azepines; Bronchitis; Capillary Permeability; Coloring Agents; Disease Models, Animal; Drug Interactions; Evans Blue; Indazoles; Leukotrienes; Male; Mechlorethamine; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Rabbits; Reference Values; Trachea; Triazoles; Vasoconstrictor Agents | 1997 |
Magnesium deficiency-dependent audiogenic seizures (MDDASs) in adult mice: a nutritional model for discriminatory screening of anticonvulsant drugs and original assessment of neuroprotection properties.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Azepines; Brain Chemistry; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Epilepsy; gamma-Aminobutyric Acid; Locomotion; Magnesium Deficiency; Melatonin; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Inbred DBA; Neuroprotective Agents; Platelet Aggregation Inhibitors; Triazoles | 1998 |
[The effect of trental and thiotriazoline on tissue blood flow, oxygen tension and vascular reactivity in the pancreas in acute experimental pancreatitis].
Topics: Acute Disease; Animals; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Hemodynamics; Oxygen Consumption; Pancreas; Pancreatitis; Pentoxifylline; Regional Blood Flow; Triazoles; Vasodilator Agents | 1998 |
Comparison of a new triazole antifungal agent, Schering 56592, with itraconazole and amphotericin B for treatment of histoplasmosis in immunocompetent mice.
Topics: Amphotericin B; Animals; Antifungal Agents; Disease Models, Animal; Histoplasma; Histoplasmosis; Immunocompetence; Itraconazole; Mice; Microbial Sensitivity Tests; Triazoles | 1999 |
Antifungal activity of voriconazole (UK-109,496), fluconazole and amphotericin B against hematogenous Candida krusei infection in neutropenic guinea pig model.
Topics: Amphotericin B; Animals; Antifungal Agents; Candida; Candidiasis; Disease Models, Animal; Drug Resistance, Microbial; Fluconazole; Guinea Pigs; Male; Neutropenia; Pyrimidines; Random Allocation; Triazoles; Voriconazole | 1999 |
A platelet activating factor receptor antagonist prevents the development of chronic arthritis in mice.
Topics: Animals; Arthritis, Rheumatoid; Azepines; Collagen; Disease Models, Animal; Female; Fibronectins; Immunohistochemistry; Joints; Mice; Mice, Inbred DBA; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thienopyridines; Triazoles | 1999 |
Adenosine and dopamine receptor antagonist binding in the rat ventral and dorsal striatum: lack of changes after a neonatal bilateral lesion of the ventral hippocampus.
Topics: Animals; Animals, Newborn; Antipsychotic Agents; Benzazepines; Corpus Striatum; Disease Models, Animal; Dopamine Antagonists; Female; Hippocampus; Male; Pregnancy; Purinergic P1 Receptor Antagonists; Pyrimidines; Raclopride; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Salicylamides; Schizophrenia; Triazoles; Xanthines | 1999 |
Captopril and platelet-activating factor (PAF) antagonist prevent cardiac allograft vasculopathy in rats: role of endogenous PAF and PAF-like compounds.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Azepines; Captopril; Coronary Disease; Disease Models, Animal; Drug Therapy, Combination; Heart Transplantation; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Random Allocation; Rats; Rats, Inbred F344; Rats, Inbred Lew; Transplantation, Homologous; Treatment Outcome; Triazoles; Ventricular Remodeling | 1999 |
Protection against ventricular fibrillation by the PAF antagonist, BN-50739, involves an ischaemia-selective mechanism.
Topics: Animals; Anti-Arrhythmia Agents; Azepines; Disease Models, Animal; Male; Myocardial Ischemia; Perfusion; Platelet Activating Factor; Protective Agents; Rats; Rats, Wistar; Triazoles; Vasodilation; Ventricular Fibrillation | 1999 |
Neutrophil A2A adenosine receptor inhibits inflammation in a rat model of meningitis: synergy with the type IV phosphodiesterase inhibitor, rolipram.
Topics: Adenosine; Animals; Blood-Brain Barrier; Cell Adhesion; Cyclic AMP; Disease Models, Animal; Drug Synergism; Humans; Leukocytosis; Meningitis, Bacterial; Neutrophil Activation; Neutrophils; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Purinergic P1; Respiratory Burst; Rolipram; Superoxides; Triazines; Triazoles; Tumor Necrosis Factor-alpha | 1999 |
The effect of combining aromatase inhibitors with antiestrogens on tumor growth in a nude mouse model for breast cancer.
Topics: Analysis of Variance; Anastrozole; Animals; Antineoplastic Combined Chemotherapy Protocols; Aromatase; Aromatase Inhibitors; Disease Models, Animal; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Female; Fulvestrant; Humans; Letrozole; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Nitriles; Tamoxifen; Time Factors; Triazoles; Tumor Cells, Cultured | 1999 |
Efficacy of SCH56592 in a rabbit model of invasive aspergillosis.
Topics: Amphotericin B; Animals; Antifungal Agents; Aspergillosis; Aspergillus; Colony Count, Microbial; Disease Models, Animal; Female; Immunosuppression Therapy; Itraconazole; Microbial Sensitivity Tests; Rabbits; Triazoles | 2000 |
SCH 56592, amphotericin B, or itraconazole therapy of experimental murine cerebral phaeohyphomycosis due to Ramichloridium obovoideum ("Ramichloridium mackenziei").
Topics: Amphotericin B; Animals; Antifungal Agents; Ascomycota; Central Nervous System Fungal Infections; Disease Models, Animal; Female; Itraconazole; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Mycoses; Triazoles | 2000 |
Efficacy of voriconazole against invasive pulmonary aspergillosis in a guinea-pig model.
Topics: Amphotericin B; Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Disease Models, Animal; Female; Fungemia; Guinea Pigs; Humans; Lung Diseases, Fungal; Microbial Sensitivity Tests; Pyrimidines; Triazoles; Voriconazole | 2000 |
Effect of WEB 2170 BS, platelet activating factor receptor inhibitor, in the guinea pig model of middle ear inflammation.
Topics: Animals; Azepines; Disease Models, Animal; Ear, Middle; Guinea Pigs; Otitis Media; Peroxidase; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Staphylococcal Infections; Temporal Bone; Triazoles | 2000 |
In vitro and in vivo activities of SCH 56592 (posaconazole), a new triazole antifungal agent, against Aspergillus and Candida.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus; Candida; Candidiasis; Disease Models, Animal; Lung Diseases, Fungal; Male; Mice; Microbial Sensitivity Tests; Treatment Outcome; Triazoles | 2000 |
Interactions between triazoles and amphotericin B against Cryptococcus neoformans.
Topics: Amphotericin B; Animals; Antifungal Agents; Cryptococcosis; Cryptococcus neoformans; Disease Models, Animal; Drug Therapy, Combination; Fluconazole; Humans; Itraconazole; Male; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Triazoles | 2000 |
Efficacies of two new antifungal agents, the triazole ravuconazole and the echinocandin LY-303366, in an experimental model of invasive aspergillosis.
Topics: Anidulafungin; Animals; Antibiotic Prophylaxis; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Brain; Disease Models, Animal; Echinocandins; Liver; Lung; Peptides, Cyclic; Rabbits; Thiazoles; Triazoles | 2000 |
Effect of WEB 2086 on leukocyte adherence in response to hemorrhagic shock in rats.
Topics: Animals; Azepines; Cell Adhesion; Disease Models, Animal; Leukocytes; Male; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Shock, Hemorrhagic; Triazoles | 2000 |
Effects of the PAF receptor antagonist UK74505 on local and remote reperfusion injuries following ischaemia of the superior mesenteric artery in the rat.
Topics: Animals; Azepines; Capillary Permeability; Dihydropyridines; Disease Models, Animal; Dose-Response Relationship, Drug; Imidazoles; Intestine, Small; Male; Mesenteric Artery, Superior; Neutrophils; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Polysaccharides; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Reperfusion Injury; Triazoles; Tumor Necrosis Factor-alpha | 2000 |
Cure of experimental Chagas' disease by the bis-triazole DO870 incorporated into 'stealth' polyethyleneglycol-polylactide nanospheres.
Topics: Animals; Chagas Disease; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Female; Mice; Microspheres; Polyesters; Polyethylene Glycols; Treatment Outcome; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2001 |
Absence of the adenosine A(2A) receptor or its chronic blockade decrease ethanol withdrawal-induced seizures in mice.
Topics: Administration, Oral; Alcohol Withdrawal Seizures; Animals; Beverages; Cacao; Disease Models, Animal; Drug Administration Schedule; Eating; Ethanol; Female; Flavoring Agents; Injections, Intraperitoneal; Male; Mice; Mice, Knockout; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A2A; Receptors, Purinergic P1; Triazines; Triazoles | 2001 |
Antifungal activity and pharmacokinetics of posaconazole (SCH 56592) in treatment and prevention of experimental invasive pulmonary aspergillosis: correlation with galactomannan antigenemia.
Topics: Animals; Antibiotic Prophylaxis; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Disease Models, Animal; Female; Galactose; Itraconazole; Lung Diseases, Fungal; Mannans; Neutropenia; Rabbits; Treatment Outcome; Triazoles | 2001 |
Interactions of posaconazole and flucytosine against Cryptococcus neoformans.
Topics: Animals; Antifungal Agents; Colony Count, Microbial; Cryptococcosis; Cryptococcus neoformans; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Flucytosine; Male; Meningitis, Cryptococcal; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Triazoles | 2001 |
In vitro antifungal activity of KP-103, a novel triazole derivative, and its therapeutic efficacy against experimental plantar tinea pedis and cutaneous candidiasis in guinea pigs.
Topics: Animals; Antifungal Agents; Blood Proteins; Candida; Candidiasis, Cutaneous; Culture Media; Disease Models, Animal; Guinea Pigs; Hair; Microbial Sensitivity Tests; Tinea Pedis; Treatment Outcome; Triazoles; Trichophyton | 2001 |
Neuroprotection by caffeine and A(2A) adenosine receptor inactivation in a model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Caffeine; Catechols; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Immunity, Innate; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuroprotective Agents; Parkinsonian Disorders; Purinergic P1 Receptor Antagonists; Purines; Pyrimidines; Receptor, Adenosine A2A; Receptors, Purinergic P1; Theobromine; Triazoles; Xanthines | 2001 |
In vitro and in vivo activities of syn2836, syn2869, syn2903, and syn2921: new series of triazole antifungal agents.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus; Candida albicans; Candidiasis; Disease Models, Animal; Mice; Microbial Sensitivity Tests; Piperazines; Treatment Outcome; Triazoles | 2001 |
Adenosine A2A receptor antagonists are potential antidepressants: evidence based on pharmacology and A2A receptor knockout mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Blepharoptosis; Disease Models, Animal; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Female; Haloperidol; Immobilization; Male; Mice; Mice, Knockout; Motor Activity; Purinergic P1 Receptor Antagonists; Purines; Pyrimidines; Receptor, Adenosine A2A; Receptors, Dopamine D2; Receptors, Purinergic P1; Reserpine; Swimming; Time Factors; Triazoles | 2001 |
Effects of adenosine receptor agonists and antagonists in a genetic animal model of primary paroxysmal dystonia.
Topics: Adenosine; Animals; Caffeine; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Dystonia; Female; Male; Mesocricetus; Muscle Contraction; Mutation; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Theobromine; Theophylline; Triazines; Triazoles; Xanthines | 2001 |
Efficacy of TAK-457, a novel intravenous triazole, against invasive pulmonary Aspergillosis in neutropenic mice.
Topics: Animals; Antifungal Agents; Aspergillosis, Allergic Bronchopulmonary; Disease Models, Animal; Female; Imidazoles; Injections, Intravenous; Mice; Mice, Inbred CBA; Neutropenia; Tetrazoles; Treatment Outcome; Triazoles | 2002 |
In vitro and in vivo activities of CS-758 (R-120758), a new triazole antifungal agent.
Topics: Animals; Antifungal Agents; Aspergillus; Candida; Cryptococcus neoformans; Disease Models, Animal; Mice; Microbial Sensitivity Tests; Mycoses; Treatment Outcome; Triazoles | 2002 |
Efficacy of ravuconazole (BMS-207147) in a guinea pig model of disseminated aspergillosis.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Disease Models, Animal; Drug Evaluation, Preclinical; Guinea Pigs; Humans; Male; Organ Culture Techniques; Organ Specificity; Thiazoles; Triazoles | 2002 |
Blockade of A(2A) adenosine receptors leads to c-fos inhibition in a rat model of brain ischemia.
Topics: Animals; Blotting, Western; Brain Ischemia; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Male; Proto-Oncogene Proteins c-fos; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Triazoles | 2002 |
Blockade of striatal adenosine A2A receptor reduces, through a presynaptic mechanism, quinolinic acid-induced excitotoxicity: possible relevance to neuroprotective interventions in neurodegenerative diseases of the striatum.
Topics: Animals; Behavior, Animal; Calcium; Cells, Cultured; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Excitatory Amino Acid Antagonists; Gliosis; Glutamic Acid; Hippocampus; Huntington Disease; Long-Term Potentiation; Male; Maze Learning; Motor Activity; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Presynaptic Terminals; Purinergic P1 Receptor Antagonists; Pyrimidines; Quinolinic Acid; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Purinergic P1; Triazoles | 2002 |
In vitro and in vivo activities of posaconazole against Coccidioides immitis.
Topics: Animals; Antifungal Agents; Coccidioides; Coccidioidomycosis; Disease Models, Animal; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Triazoles | 2002 |
Comparison of azoles against aspergilli in vitro and in an experimental model of pulmonary aspergillosis.
Topics: Amphotericin B; Animals; Antifungal Agents; Aspergillosis; Aspergillosis, Allergic Bronchopulmonary; Aspergillus; Aspergillus flavus; Aspergillus fumigatus; Disease Models, Animal; Itraconazole; Ketoconazole; Male; Rats; Rats, Inbred Strains; Triazoles | 1992 |
Comparative study of six antifungal treatments in an experimental model of murine cryptococcosis.
Topics: Amphotericin B; Animals; Antifungal Agents; Cryptococcosis; Cryptococcus neoformans; Disease Models, Animal; Drug Administration Schedule; Drug Therapy, Combination; Fluconazole; Flucytosine; Itraconazole; Ketoconazole; Mice; Mice, Inbred BALB C; Triazoles | 1992 |
Suppression of the Arthus reaction by Y-24180, a potent and specific antagonist of platelet-activating factor.
Topics: Animals; Arthus Reaction; Azepines; Capillary Permeability; Disease Models, Animal; Female; Guinea Pigs; Male; Molecular Structure; Ovalbumin; Pancreatitis; Platelet Activating Factor; Rabbits; Rats; Rats, Inbred Strains; Skin; Skin Diseases; Triazoles | 1992 |
Azole therapy for trichosporonosis: clinical evaluation of eight patients, experimental therapy for murine infection, and review.
Topics: Adult; Aged; Amphotericin B; Animals; Antifungal Agents; Child, Preschool; Disease Models, Animal; Female; Fluconazole; Humans; Immunocompromised Host; Male; Mice; Miconazole; Middle Aged; Mycoses; Triazoles; Trichosporon | 1992 |
Effect of WEB 2086 on myocardial infarct size and regional blood flow in the dog.
Topics: Animals; Azepines; Cardiac Output; Coronary Disease; Disease Models, Animal; Dogs; Myocardial Infarction; Myocardium; Platelet Activating Factor; Regional Blood Flow; Triazoles | 1992 |
WEB 2086 inhibits neutrophil dependent increases in coronary resistance in blood perfused rabbit heart.
Topics: Animals; Azepines; Disease Models, Animal; Myocardial Reperfusion Injury; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Rabbits; Triazoles; Vascular Resistance | 1992 |
The platelet activating factor receptor antagonist WEB 2170 improves glomerular hemodynamics and morphology in a proliferative model of mesangial cell injury.
Topics: Animals; Antilymphocyte Serum; Azepines; Dinoprostone; Disease Models, Animal; Glomerular Filtration Rate; Glomerular Mesangium; Glomerulonephritis; Inulin; Male; Platelet Membrane Glycoproteins; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thromboxane B2; Triazoles | 1991 |
Inhibition of cyclic flow variations and reocclusion after thrombolysis in dogs by a novel antagonist of platelet-activating factor.
Topics: Administration, Oral; Animals; Benzodiazepines; Bleeding Time; Blood Coagulation; Blood Flow Velocity; Coronary Thrombosis; Disease Models, Animal; Dogs; Drug Therapy, Combination; Hemodynamics; Partial Thromboplastin Time; Platelet Activating Factor; Platelet Aggregation; Platelet Count; Prothrombin Time; Recurrence; Tissue Plasminogen Activator; Triazolam; Triazoles | 1991 |
Effects of YM264, a novel PAF antagonist, on puromycin aminonucleoside-induced nephropathy in the rat.
Topics: Animals; Azepines; Disease Models, Animal; Glomerulonephritis, Membranous; Hypercholesterolemia; Male; Metabolic Clearance Rate; Methylprednisolone; Piperazines; Platelet Activating Factor; Proteinuria; Puromycin Aminonucleoside; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines; Ticlopidine; Triazoles | 1991 |
Allergen-induced bronchospasm in passively sensitized guinea pigs: influence of new substances in comparison to reference compounds.
Topics: Acrylates; Allergens; Animals; Azepines; Benzoates; Bronchial Spasm; Disease Models, Animal; Guinea Pigs; Immunization, Passive; Male; Ovalbumin; Phospholipases A; Platelet Activating Factor; Tetrazoles; Thienopyridines; Triazoles | 1991 |
[Involvement of platelet activating factor (PAF) in ovalbumin antigen-induced late asthmatic response and increase of airway hyperresponsiveness in a guinea pig experimental model of asthma].
Topics: Airway Resistance; Animals; Asthma; Azepines; Disease Models, Animal; Guinea Pigs; Hypersensitivity, Delayed; Male; Ovalbumin; Platelet Activating Factor; Triazoles | 1991 |
Preclinical antimycotic activity of SDZ 89-485: a new orally and topically effective triazole.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Candida albicans; Candidiasis; Candidiasis, Vulvovaginal; Culture Media; Disease Models, Animal; Female; Guinea Pigs; Histoplasmosis; Humans; Mice; Mycoses; Nephritis; Rats; Sporotrichosis; Tinea; Triazoles | 1990 |
[Subchronic toxic effect of the grain fungicide PF-70 on the electrolyte barrier of the gastric mucosa in rats].
Topics: Action Potentials; Animals; Chronic Disease; Disease Models, Animal; Edible Grain; Electric Conductivity; Female; Fungicides, Industrial; Gastric Mucosa; Male; Maneb; Rats; Rats, Inbred Strains; Sulfur; Triazoles; Zineb | 1990 |
Effects of NMDA receptor antagonists and body temperature in the gerbil carotid occlusion model of transient forebrain ischemia.
Topics: Animals; Anticonvulsants; Body Temperature; Brain; Brain Diseases; Carotid Arteries; Corpus Striatum; Disease Models, Animal; Dizocilpine Maleate; Gerbillinae; Hippocampus; Hypothermia; Ischemic Attack, Transient; Male; Pipecolic Acids; Pyramidal Tracts; Receptors, N-Methyl-D-Aspartate; Triazoles | 1990 |
Evaluation of Bay R 3783 in rodent models of superficial and systemic candidiasis, meningeal cryptococcosis, and pulmonary aspergillosis.
Topics: Administration, Oral; Amphotericin B; Animals; Antifungal Agents; Aspergillosis; Candidiasis; Cryptococcosis; Disease Models, Animal; Drug Administration Schedule; Evaluation Studies as Topic; Female; Fluconazole; Itraconazole; Ketoconazole; Lung Diseases, Fungal; Male; Meningitis; Mice; Pharmaceutical Vehicles; Rats; Rats, Inbred Strains; Triazoles | 1990 |
Treatment of chronic murine chromoblastomycosis with the triazole SCH39304.
Topics: Animals; Antifungal Agents; Chromoblastomycosis; Chronic Disease; Disease Models, Animal; Female; Itraconazole; Ketoconazole; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Electron; Mitosporic Fungi; Skin; Triazoles | 1990 |
Evidence for platelet-activating factor as a novel mediator in experimental stroke in rabbits.
Topics: Animals; Azepines; Cerebrovascular Disorders; Disease Models, Animal; Platelet Activating Factor; Rabbits; Reference Values; Regional Blood Flow; Spinal Cord; Spinal Cord Injuries; Triazoles | 1990 |
SCH-39304 in prevention and treatment of disseminated candidiasis in persistently granulocytopenic rabbits.
Topics: Agranulocytosis; Amphotericin B; Animals; Anti-Bacterial Agents; Antifungal Agents; Candida albicans; Candidiasis; Disease Models, Animal; Female; Fluconazole; Immunosuppression Therapy; Rabbits; Triazoles | 1990 |
Platelet-activating factor: evidence against a role in hypoxic pulmonary vasoconstriction.
Topics: Animals; Azepines; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Injections, Intravenous; Male; Platelet Activating Factor; Pulmonary Circulation; Swine; Triazoles; Vascular Resistance; Vasoconstriction | 1990 |
Therapeutic effect of the triazole Bay R 3783 in mouse models of coccidioidomycosis, blastomycosis, and histoplasmosis.
Topics: Animals; Antifungal Agents; Biological Assay; Blastomycosis; Coccidioidomycosis; Disease Models, Animal; Female; Histoplasmosis; Mice; Microbial Sensitivity Tests; Survival Rate; Triazoles | 1990 |
The pathophysiological role of PAF in anaphylactic lung reaction in the guinea pig and in endotoxin shock evidenced by the specific PAF-antagonist WEB 2086.
Topics: Anaphylaxis; Animals; Antigens; Azepines; Disease Models, Animal; Endotoxins; Escherichia coli; Guinea Pigs; Lung Diseases; Ovalbumin; Platelet Activating Factor; Pyrilamine; Shock, Septic; Triazines; Triazoles | 1989 |
A possible role for PAF in allergen-induced late responses: modification by a selective antagonist.
Topics: Aerosols; Allergens; Animals; Antigens, Helminth; Ascaris; Asthma; Azepines; Chlorpheniramine; Chromones; Disease Models, Animal; Hypersensitivity, Delayed; Hypersensitivity, Immediate; Indomethacin; Lung; Platelet Activating Factor; Reference Values; Sheep; SRS-A; Triazines; Triazoles | 1989 |
[Experimental renal infection with Aspergillus fumigatus in mice: a chemotherapeutic model of an organic mycosis].
Topics: Amphotericin B; Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Disease Models, Animal; Female; Flucytosine; Itraconazole; Ketoconazole; Kidney Diseases; Mice; Mice, Inbred Strains; Miconazole; Triazoles | 1985 |
Azole resistance in Candida albicans.
Topics: Adult; Animals; Antifungal Agents; Candida albicans; Candidiasis; Candidiasis, Chronic Mucocutaneous; Disease Models, Animal; Drug Resistance, Microbial; Econazole; Female; Fluconazole; Guinea Pigs; Humans; Imidazoles; Itraconazole; Ketoconazole; Male; Mice; Miconazole; Rats; Rats, Inbred Strains; Triazoles | 1986 |
A diffusion chamber technique for testing of antifungal drugs against Sporothrix schenckii in vivo.
Topics: Amphotericin B; Animals; Antifungal Agents; Disease Models, Animal; Female; Itraconazole; Ketoconazole; Mice; Potassium Iodide; Sporothrix; Sporotrichosis; Triazoles | 1986 |
Activity of ICI 195,739--a novel, orally active bistriazole--in rodent models of fungal and protozoal infections.
Topics: Animals; Antifungal Agents; Antiprotozoal Agents; Candidiasis, Vulvovaginal; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Malaria; Mice; Rats; Structure-Activity Relationship; Tinea; Triazoles; Trypanosomiasis | 1988 |