Compounds > tetrahydrophthalimide
Page last updated: 2024-11-05

tetrahydrophthalimide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Tetrahydrophthalimide (THPI) is a cyclic imide derived from phthalic anhydride. It is a white crystalline solid with a melting point of 145-148 °C. THPI is used as a monomer in the production of polymers, such as polyimides and polyamides. It is also used as an intermediate in the synthesis of other organic compounds. THPI is a versatile chemical with a wide range of applications, including in the fields of pharmaceuticals, agriculture, and materials science. It is also used as a catalyst in various organic reactions. THPI is a potential candidate for use in the production of novel materials with enhanced properties.'

tetrahydrophthalimide: captan metabolite in fruit crops [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID6808
CHEMBL ID3187796
SCHEMBL ID1568506
MeSH IDM0054106

Synonyms (70)

Synonym
1h-isoindole-1,3(2h)-dione, 3a,4,7,7a-tetrahydro-
3a,4,7,7a-tetrahydro-1h-isoindole-1,3(2h)-dione
ccris 3648
nsc 59011
brn 0128764
hsdb 5006
isoindole-1,3-dione, 3a,4,7,7a-tetrahydro-
1h-isoindole-1,3(2h)-dione, 3-alpha,4,7,7-alpha-tetrahydro-
einecs 201-602-8
delta(sup 4)-tetrahydrophthalimide
delta(4)-tetrahydrophthalimide
tetrahydrophthalimide (van)
1,2,3,6-tetrahydrophthalimide
isoindole-1, 3a,4,7,7a-tetrahydro-
nsc59011
1,3,6-tetrahydrophthalimide
.delta.4-tetrahydrophthalimide
nsc-59011
tetrahydrophthalic acid imide
85-40-5
1h-isoindole-1, 3a,4,7,7a-tetrahydro-
4-cyclohexene-1,2-dicarboximide
tetrahydrophthalimide
3a,4,7,7a-tetrahydroisoindole-1,3-dione
FT-0655614
inchi=1/c8h9no2/c10-7-5-3-1-2-4-6(5)8(11)9-7/h1-2,5-6h,3-4h2,(h,9,10,11)
ciffbtojcksrjy-uhfffaoysa-
HMS1722F15
AKOS001040878
NCGC00248318-01
ec 201-602-8
5-21-10-00130 (beilstein handbook reference)
STK724078
dtxcid106513
tox21_301178
dtxsid8026513 ,
cas-85-40-5
NCGC00255076-01
1,2,3,6-tetrahydrophthalimide, 4-cyclohexene-1,2-dicarboximide, thpi
FT-0675043
AKOS025243539
SCHEMBL1568506
AKOS016842521
1,2,3,6-tetrahydrophtalimide
3a,4,7,7a-tetrahydro-1h-isoindole-1,3(2h)-dione #
W-104083
1,2,3,6-tetrahydro phthalimide
FD14008
CHEMBL3187796
3alpha,4,7,7alpha-tetrahydro-1h-isoindole-1,3(2h)-dione
2,3,3a,4,7,7a-hexahydro-1h-isoindole-1,3-dione
mfcd00042782
mfcd00005880
3-hydroxy-3a,4,7,7a-tetrahydro-1h-isoindol-1-one
AC-8837
tetrahydrophthalimid
3a,4,7,7a-tetrahydro-cis-1h-isoindole-1,3(2h)-dione
3-alpha,4,7,7-alpha-tetrahydro-1h-isoindole-1,3(2h)-dione
3a,4,7,7a-tetrahydro-isoindole-1,3-dione
laquo deltaraquo 4-tetrahydrophthalimide
1,2,5,6-tetrahydrophthalimide
SY003867
CS-0077658
FT-0739667
Q21045269
AMY10828
EN300-05179
SB66392
SY102061
Z56893117
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (3)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
progesterone receptorHomo sapiens (human)Potency0.24340.000417.946075.1148AID1346795
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency54.48270.003041.611522,387.1992AID1159552
thyroid stimulating hormone receptorHomo sapiens (human)Potency2.73060.001628.015177.1139AID1259385
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (21)

TimeframeStudies, This Drug (%)All Drugs %
pre-19906 (28.57)18.7374
1990's3 (14.29)18.2507
2000's1 (4.76)29.6817
2010's11 (52.38)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 32.70

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index32.70 (24.57)
Research Supply Index3.37 (2.92)
Research Growth Index4.86 (4.65)
Search Engine Demand Index45.47 (26.88)
Search Engine Supply Index2.29 (0.95)

This Compound (32.70)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials2 (7.69%)5.53%
Reviews0 (0.00%)6.00%
Case Studies1 (3.85%)4.05%
Observational0 (0.00%)0.25%
Other23 (88.46%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
hexachloroethane
[no description available]		2.0610chlorocarbon;
chloroethanes		carcinogenic agent;
refrigerant
ethane
Ethane: A two carbon alkane with the formula H3C-CH3.. ethane : An alkane comprising of two carbon atoms.		2.0610alkane;
gas molecular entity		plant metabolite;
refrigerant
carbon disulfide
Carbon Disulfide: A colorless, flammable, poisonous liquid, CS2. It is used as a solvent, and is a counterirritant and has local anesthetic properties but is not used as such. It is highly toxic with pronounced CNS, hematologic, and dermatologic effects.		2.0610one-carbon compound;
organosulfur compound
phthalimide
phthalimide: RN given refers to parent cpd. phthalimide : A dicarboximide that is 2,3-dihydro-1H-isoindole substituted by oxo groups at positions 1 and 3.		9.4141phthalimides
4,4'-dichlorobenzophenone
4,4'-dichlorobenzophenone: structure		2.1710benzophenones
benzonitrile
benzonitrile : A nitrile that is hydrogen cyanide in which the hydrogen has been replaced by a phenyl group.		2.0610benzenes;
nitrile
captan
Captan: One of the phthalimide fungicides.. captan : A dicarboximide that is 3a,4,7,7a-tetrahydrophthalimide in which the hydrogen attached to the nitrogen is replaced by a trichloromethyl group. A non-systemic fungicide introduced in the 1950s, it is widely used for the control of fungal diseases in fruits, vegetables, and ornamental crops.		6.25192isoindoles;
organochlorine compound;
organosulfur compound;
phthalimide fungicide		antifungal agrochemical
folpet
folpet : A member of the class of phthalimides that is phthalimide in which the hydrogen attached to the nitrogen is replaced by a trichloromethylthio group. An agricultural fungicide, it has been used to control mildew, leaf spot, and other diseases in crops sice the 1950s.		9.9542organochlorine compound;
organosulfur compound;
phthalimide fungicide		antifungal agrochemical
thiazoles
[no description available]		2.38201,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
aminoimidazole carboxamide
Aminoimidazole Carboxamide: An imidazole derivative which is a metabolite of the antineoplastic agents BIC and DIC. By itself, or as the ribonucleotide, it is used as a condensation agent in the preparation of nucleosides and nucleotides. Compounded with orotic acid, it is used to treat liver diseases.. 5-aminoimidazole-4-carboxamide : An aminoimidazole in which the amino group is at C-5 with a carboxamido group at C-4.		2.2110aminoimidazole;
monocarboxylic acid amide		mouse metabolite
hydantoins
Hydantoins: Compounds based on imidazolidine dione. Some derivatives are ANTICONVULSANTS.. imidazolidine-2,4-dione : An imidazolidinone with oxo groups at position 2 and 4.		2.2110imidazolidine-2,4-dione
thiazolidines
Thiazolidines: Reduced (protonated) form of THIAZOLES. They can be oxidized to THIAZOLIDINEDIONES.		2.3820thiazolidine
3,4,5,6-tetrahydrophthalic acid anhydride
3,4,5,6-tetrahydrophthalic acid anhydride: RN given refers to cpd with locants as specified		1.9610
tetrabutylammonium
tetrabutylammonium: lipophilic probe; RN given refers to parent cpd		7.0510quaternary ammonium ion
methionine sulfoximine
methionine sulfoximine : A non-proteinogenic alpha-amino acid that is the sulfoximine derivative of methionine .		1.9710methionine derivative;
non-proteinogenic alpha-amino acid;
sulfoximide
captafol
captafol: RN given refers to cpd with specified chlorine locants. captafol : A dicarboximide that captan in which the trichloromethyl group is replaced by a 1,1,2,2-tetrachloroethyl group. A broad-spectrum fungicide used to control diseases in fruit and potatoes, it is no longer approved for use in the European Community.		7.2110isoindoles;
organochlorine compound;
organosulfur compound;
phthalimide fungicide		antifungal agrochemical
buthionine sulfoximine
Buthionine Sulfoximine: A synthetic amino acid that depletes glutathione by irreversibly inhibiting gamma-glutamylcysteine synthetase. Inhibition of this enzyme is a critical step in glutathione biosynthesis. It has been shown to inhibit the proliferative response in human T-lymphocytes and inhibit macrophage activation. (J Biol Chem 1995;270(33):1945-7). 2-amino-4-(S-butylsulfonimidoyl)butanoic acid : A non-proteinogenic alpha-amino acid that is homocysteine in which the thiol group carries an oxo, imino and butyl groups.. S-butyl-DL-homocysteine (S,R)-sulfoximine : A sulfoximide that is the sulfoximine derivative of an analogue of DL-methionine in which the S-methyl group is replaced by S-butyl.		1.9710diastereoisomeric mixture;
homocysteines;
non-proteinogenic alpha-amino acid;
sulfoximide		EC 6.3.2.2 (glutamate--cysteine ligase) inhibitor;
ferroptosis inducer
tetrachloroethylene
Tetrachloroethylene: A chlorinated hydrocarbon used as an industrial solvent and cooling liquid in electrical transformers. It is a potential carcinogen.		2.0610chlorocarbon;
chloroethenes		nephrotoxic agent
iprodione
iprodione : An imidazolidine-2,4-dione in which the nitrogen at position 1 is substituted by an N-(isopropyl)carboxamide group while that at position 3 is substituted by a 3,5-dichlorophenyl group. A contact fungicide, it blocks the growth of the fungal mycelium and inhibits the germination of fungal spores. It is used on fruit and vegetable crops affected by various fungal diseases. It is also used as a nematicide.		7.2110benzenes;
dichlorophenyl dicarboximide fungicide;
imidazole fungicide;
imidazolidine-2,4-dione;
ureas		antifungal agrochemical;
nematicide
dimethylhydrazines
Dimethylhydrazines: Hydrazines substituted with two methyl groups in any position.		1.9710
triazoles
Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.		2.15101,2,3-triazole
tetramethrin
tetramethrin: structure		1.9710cyclopropanecarboxylate ester;
maleimides;
phthalimide insecticide		pyrethroid ester insecticide
tebuconazole
Lynx: A genus in the family FELIDAE comprising felines with long legs, ear tufts, and a short tail.. 1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol : A tertiary alcohol that is pentan-3-ol substituted by a 4-chlorophenyl, methyl, methyl, and a 1H-1,2,4-triazol-1-ylmethyl at positions 1, 4, 4 and 3 respectively.. tebuconazole : A racemate composed of equimolar amounts of (R)- and (S)-tebuconazole. A fungicide effective against various smut and bunt diseases in cereals and other field crops.		2.1510monochlorobenzenes;
tertiary alcohol;
triazoles
2-thioxo-4-thiazolidinecarboxylic acid
2-thioxo-4-thiazolidinecarboxylic acid: in urine of workers exposed to carbon disulfide		2.3820organonitrogen compound;
organooxygen compound
sulfur
Sulfur: An element that is a member of the chalcogen family. It has an atomic symbol S, atomic number 16, and atomic weight [32.059; 32.076]. It is found in the amino acids cysteine and methionine.		1.9710chalcogen;
nonmetal atom		macronutrient
fumarates
Fumarates: Compounds based on fumaric acid.. fumarate(2-) : A C4-dicarboxylate that is the E-isomer of but-2-enedioate(2-)		2.0510butenedioate;
C4-dicarboxylate		human metabolite;
metabolite;
Saccharomyces cerevisiae metabolite
pyrethrins
[no description available]		1.9710
ConditionIndicatedRelationship StrengthStudiesTrials
Encephalitis, Polio
[description not available]		02.0610
Poliomyelitis
An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)		02.0610