Compounds > 4-(3-(benzotriazol-1-yl)propyl)-1-(2-methoxyphenyl)piperazine
Page last updated: 2024-12-07

4-(3-(benzotriazol-1-yl)propyl)-1-(2-methoxyphenyl)piperazine

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Description

4-(3-(benzotriazol-1-yl)propyl)-1-(2-methoxyphenyl)piperazine: a putative 5-HT1A receptor antagonist; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID133001
CHEMBL ID91806
SCHEMBL ID4092923
MeSH IDM0235336

Synonyms (19)

Synonym
CHEMBL91806 ,
1-{3-[4-(2-methoxy-phenyl)-piperazin-1-yl]-propyl}-1h-benzotriazole
bdbm50039784
1-(3-(4-(2-methoxyhenyl)-1-piperazinyl)propyl)-1h-benzotriazole
1-(3-(4-(2-methoxyphenyl)-1-piperazinyl)propyl)-1h-benzotriazole
156007-21-5
4-(3-(benzotriazol-1-yl)propyl)-1-(2-methoxyphenyl)piperazine
1h-benzotriazole, 1-(3-(4-(2-methoxyhenyl)-1-piperazinyl)propyl)-
mp-3022
mp 3022
1h-benzotriazole, 1-(3-(4-(2-methoxyphenyl)-1-piperazinyl)propyl)-
bpmpp
1-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propyl]benzotriazole
SCHEMBL4092923
CMDFESOYJXRUSW-UHFFFAOYSA-N
1-(3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl)-1h-1,2,3-benzotriazole #
4-[3-(benzotriazol-1-yl)propyl-1-(2-methoxyphenyl)piperazine
DTXSID60166030
PD069127
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (4)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
5-hydroxytryptamine receptor 2CRattus norvegicus (Norway rat)Ki1.04000.00020.667710.0000AID5107
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)Ki1.04000.00010.601710.0000AID5107
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)Ki0.01500.00010.739610.0000AID4201; AID4349
5-hydroxytryptamine receptor 2BRattus norvegicus (Norway rat)Ki1.04000.00020.590910.0000AID5107
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (77)

Assay IDTitleYearJournalArticle
AID184988Tested for the induction of lower lip retraction (LLR) by the investigated compounds in rat at dosage of 2 mg/kg1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID234635Selectivity is the ratio between Ki values of 5-HT2 and 5-HT1A1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID184989Tested for the induction of lower lip retraction (LLR) by the investigated compounds in rat at dosage of 4 mg/kg1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID180968Effect on 8-OH-DAPT- induced behavioral syndrome(FT: forepaw treading) by the compound in reserpine pretreated rats at a dose of 8; FT mean score1999Journal of medicinal chemistry, Dec-02, Volume: 42, Issue:24
On the bioactive conformation of NAN-190 (1) and MP3022 (2), 5-HT(1A) receptor antagonists.
AID178774Effective dose of the required to inhibit symptoms produced by 8-OH-DPAT1999Journal of medicinal chemistry, Dec-02, Volume: 42, Issue:24
On the bioactive conformation of NAN-190 (1) and MP3022 (2), 5-HT(1A) receptor antagonists.
AID122982Effect on body temperature in mice at intraperitoneal dosage of 8 mg/kg, (compound administered 30 min before the test) after 75 min1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID122983Effect on body temperature in mice at intraperitoneal dosage of 8 mg/kg, (compound administered 30 min before the test) after 90 min1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID122812Effect on 8-OH-DPAT-induced hypothermia in mice (5 mg/kg) at intraperitoneal dosage of 2 mg/kg of compound after 30 mins1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID184987Tested for the induction of lower lip retraction (LLR) by the investigated compounds in rat at dosage of 16 mg/kg1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID172499Tested for the effect on 8-OH-DPAT-induced behavior in reserpine pretreated rat against forepaw treading at dosage of 2 mg/kg1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID122814Effect on 8-OH-DPAT-induced hypothermia in mice (5 mg/kg) at intraperitoneal dosage of 2 mg/kg of compound after 60 mins1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID180794Induction of behavioral syndrome(FBP: flat body posture) by the compound in reserpine pretreated rats at a dose of 8; FBP mean score1999Journal of medicinal chemistry, Dec-02, Volume: 42, Issue:24
On the bioactive conformation of NAN-190 (1) and MP3022 (2), 5-HT(1A) receptor antagonists.
AID122975Effect on body temperature in mice at intraperitoneal dosage of 4 mg/kg, (compound administered 30 min before the test) after 60 min1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID5107Tested in vitro for receptor binding affinity against 5-hydroxytryptamine 2 receptor using radioligand [3H]ketanserin1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID122977Effect on body temperature in mice at intraperitoneal dosage of 4 mg/kg, (compound administered 30 min before the test) after 90 min1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID122972Effect on body temperature in mice at intraperitoneal dosage of 2 mg/kg, (compound administered 30 min before the test) after 90 min1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID172501Tested for the effect on 8-OH-DPAT-induced behavior in reserpine pretreated rat against forepaw treading at dosage of 8 mg/kg1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID122825Effect on 8-OH-DPAT-induced hypothermia in mice (5 mg/kg) at intraperitoneal dosage of 8 mg/kg of compound after 30 mins1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID122829Effect on 8-OH-DPAT-induced hypothermia in mice (5 mg/kg) at intraperitoneal dosage of 8 mg/kg of compound after 60 mins1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID180785Effect on 8-OH-DAPT- induced behavioral syndrome(FBP: flat body posture) by the compound in reserpine pretreated rats at a dose of 8; FBP mean score1999Journal of medicinal chemistry, Dec-02, Volume: 42, Issue:24
On the bioactive conformation of NAN-190 (1) and MP3022 (2), 5-HT(1A) receptor antagonists.
AID176737Dose Inducing behavioral syndrome(FBP: flat body posture) by the compound in reserpine pretreated rats1999Journal of medicinal chemistry, Dec-02, Volume: 42, Issue:24
On the bioactive conformation of NAN-190 (1) and MP3022 (2), 5-HT(1A) receptor antagonists.
AID122813Effect on 8-OH-DPAT-induced hypothermia in mice (5 mg/kg) at intraperitoneal dosage of 2 mg/kg of compound after 45 mins1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID184976Induction of LLR(lower lip retraction) by the compound in rats at a dose of 16 mg/kg; LLR score1999Journal of medicinal chemistry, Dec-02, Volume: 42, Issue:24
On the bioactive conformation of NAN-190 (1) and MP3022 (2), 5-HT(1A) receptor antagonists.
AID180966Effect on 8-OH-DAPT- induced behavioral syndrome(FT: forepaw treading) by the compound in reserpine pretreated rats at a dose of 4; FT mean score1999Journal of medicinal chemistry, Dec-02, Volume: 42, Issue:24
On the bioactive conformation of NAN-190 (1) and MP3022 (2), 5-HT(1A) receptor antagonists.
AID122980Effect on body temperature in mice at intraperitoneal dosage of 8 mg/kg, (compound administered 30 min before the test) after 45 min1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID184980Induction of LLR(lower lip retraction) by the compound in rats at a dose of 8 mg/kg; LLR score1999Journal of medicinal chemistry, Dec-02, Volume: 42, Issue:24
On the bioactive conformation of NAN-190 (1) and MP3022 (2), 5-HT(1A) receptor antagonists.
AID172494Tested for the effect on 8-OH-DPAT-induced behavior in reserpine pretreated rat against flat body posture at dosage of 4 mg/kg1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID180777Effect on 8-OH-DAPT- induced behavioral syndrome(FBP: flat body posture) by the compound in reserpine pretreated rats at a dose of 16; FBP mean score1999Journal of medicinal chemistry, Dec-02, Volume: 42, Issue:24
On the bioactive conformation of NAN-190 (1) and MP3022 (2), 5-HT(1A) receptor antagonists.
AID172493Tested for the effect on 8-OH-DPAT-induced behavior in reserpine pretreated rat against flat body posture at dosage of 2 mg/kg1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID122832Effect on body temperature in mice at intraperitoneal dosage of 1 mg/kg, (compound administered 30 min before the test) after 60 min1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID184983Tested for the effect on 8-OH-DPAT-induced lower lip retraction (LLR) in rat at dosage of 4 mg/kg1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID172500Tested for the effect on 8-OH-DPAT-induced behavior in reserpine pretreated rat against forepaw treading at dosage of 4 mg/kg1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID122821Effect on 8-OH-DPAT-induced hypothermia in mice (5 mg/kg) at intraperitoneal dosage of 4 mg/kg of compound after 60 mins1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID122817Effect on 8-OH-DPAT-induced hypothermia in mice (5 mg/kg) at intraperitoneal dosage of 4 mg/kg of compound after 30 mins1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID180972Induction of behavioral syndrome(FT: forepaw treading) by the compound in reserpine pretreated rats at a dose of 16; FT mean score1999Journal of medicinal chemistry, Dec-02, Volume: 42, Issue:24
On the bioactive conformation of NAN-190 (1) and MP3022 (2), 5-HT(1A) receptor antagonists.
AID4349Tested in vitro for receptor binding affinity against 5-hydroxytryptamine 1A receptor using radioligand [3H]8-OH-DPAT1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID184990Tested for the induction of lower lip retraction (LLR) by the investigated compounds in rat at dosage of 8 mg/kg1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID122974Effect on body temperature in mice at intraperitoneal dosage of 4 mg/kg, (compound administered 30 min before the test) after 45 min1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID122827Effect on 8-OH-DPAT-induced hypothermia in mice (5 mg/kg) at intraperitoneal dosage of 8 mg/kg of compound after 45 mins1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID180962Effect on 8-OH-DAPT- induced behavioral syndrome(FT: forepaw treading) by the compound in reserpine pretreated rats at a dose of 16; FT mean score1999Journal of medicinal chemistry, Dec-02, Volume: 42, Issue:24
On the bioactive conformation of NAN-190 (1) and MP3022 (2), 5-HT(1A) receptor antagonists.
AID184969Effect on 8-OH-DPAT-Induced LLR(lower lip retraction) in rats at a dose of 16 mg/kg; LLR score1999Journal of medicinal chemistry, Dec-02, Volume: 42, Issue:24
On the bioactive conformation of NAN-190 (1) and MP3022 (2), 5-HT(1A) receptor antagonists.
AID122684Effect on 8-OH-DPAT-induced hypothermia in mice (5 mg/kg) at intraperitoneal dosage of 1 mg/kg of compound after 30 mins1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID122976Effect on body temperature in mice at intraperitoneal dosage of 4 mg/kg, (compound administered 30 min before the test) after 75 min1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID122843Effect on body temperature in mice at intraperitoneal dosage of 2 mg/kg, (compound administered 30 min before the test) after 45 min1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID172495Tested for the effect on 8-OH-DPAT-induced behavior in reserpine pretreated rat against flat body posture at dosage of 8 mg/kg1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID184984Tested for the effect on 8-OH-DPAT-induced lower lip retraction (LLR) in rat at dosage of 8 mg/kg1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID122683Effect on 8-OH-DPAT-induced hypothermia in mice (5 mg/kg) at intraperitoneal dosage of 1 mg/kg of compound after 15 mins1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID122842Effect on body temperature in mice at intraperitoneal dosage of 2 mg/kg, (compound administered 30 min before the test) after 30 min1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID122685Effect on 8-OH-DPAT-induced hypothermia in mice (5 mg/kg) at intraperitoneal dosage of 1 mg/kg of compound after 45 mins1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID122979Effect on body temperature in mice at intraperitoneal dosage of 8 mg/kg, (compound administered 30 min before the test) after 30 min1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID181114Induction of behavioral syndrome(FT: forepaw treading) by the compound in reserpine pretreated rats at a dose of 8; FT mean score1999Journal of medicinal chemistry, Dec-02, Volume: 42, Issue:24
On the bioactive conformation of NAN-190 (1) and MP3022 (2), 5-HT(1A) receptor antagonists.
AID184982Tested for the effect on 8-OH-DPAT-induced lower lip retraction (LLR) in rat at dosage of 2 mg/kg1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID4201Ability to displace [3H]8-OH-DPAT from 5-hydroxytryptamine 1A receptor1999Journal of medicinal chemistry, Dec-02, Volume: 42, Issue:24
On the bioactive conformation of NAN-190 (1) and MP3022 (2), 5-HT(1A) receptor antagonists.
AID184981Tested for the effect on 8-OH-DPAT-induced lower lip retraction (LLR) in rat at dosage of 16 mg/kg1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID122811Effect on 8-OH-DPAT-induced hypothermia in mice (5 mg/kg) at intraperitoneal dosage of 2 mg/kg of compound after 15 mins1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID172498Tested for the effect on 8-OH-DPAT-induced behavior in reserpine pretreated rat against forepaw treading at dosage of 16 mg/kg1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID176742Dose Inducing behavioral syndrome(FT: forepaw treading) by the compound in reserpine pretreated rats.1999Journal of medicinal chemistry, Dec-02, Volume: 42, Issue:24
On the bioactive conformation of NAN-190 (1) and MP3022 (2), 5-HT(1A) receptor antagonists.
AID122971Effect on body temperature in mice at intraperitoneal dosage of 2 mg/kg, (compound administered 30 min before the test) after 75 min1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID122686Effect on 8-OH-DPAT-induced hypothermia in mice (5 mg/kg) at intraperitoneal dosage of 1 mg/kg of compound after 60 mins1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID122823Effect on 8-OH-DPAT-induced hypothermia in mice (5 mg/kg) at intraperitoneal dosage of 8 mg/kg of compound after 15 mins1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID122831Effect on body temperature in mice at intraperitoneal dosage of 1 mg/kg, (compound administered 30 min before the test) after 45 min1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID180787Induction of behavioral syndrome(FBP: flat body posture) by the compound in reserpine pretreated rats at a dose of 16; FBP mean score1999Journal of medicinal chemistry, Dec-02, Volume: 42, Issue:24
On the bioactive conformation of NAN-190 (1) and MP3022 (2), 5-HT(1A) receptor antagonists.
AID122833Effect on body temperature in mice at intraperitoneal dosage of 1 mg/kg, (compound administered 30 min before the test) after 75 min1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID122973Effect on body temperature in mice at intraperitoneal dosage of 4 mg/kg, (compound administered 30 min before the test) after 30 min1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID122981Effect on body temperature in mice at intraperitoneal dosage of 8 mg/kg, (compound administered 30 min before the test) after 60 min1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID122834Effect on body temperature in mice at intraperitoneal dosage of 1 mg/kg, (compound administered 30 min before the test) after 90 min1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID184979Induction of LLR(lower lip retraction) by the compound in rats at a dose of 4 mg/kg; LLR score1999Journal of medicinal chemistry, Dec-02, Volume: 42, Issue:24
On the bioactive conformation of NAN-190 (1) and MP3022 (2), 5-HT(1A) receptor antagonists.
AID172492Tested for the effect on 8-OH-DPAT-induced behavior in reserpine pretreated rat against flat body posture at dosage of 16 mg/kg1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID180781Effect on 8-OH-DAPT- induced behavioral syndrome(FBP: flat body posture) by the compound in reserpine pretreated rats at a dose of 4; FBP mean score1999Journal of medicinal chemistry, Dec-02, Volume: 42, Issue:24
On the bioactive conformation of NAN-190 (1) and MP3022 (2), 5-HT(1A) receptor antagonists.
AID184971Effect on 8-OH-DPAT-Induced LLR(lower lip retraction) in rats at a dose of 4 mg/kg; LLR score1999Journal of medicinal chemistry, Dec-02, Volume: 42, Issue:24
On the bioactive conformation of NAN-190 (1) and MP3022 (2), 5-HT(1A) receptor antagonists.
AID122819Effect on 8-OH-DPAT-induced hypothermia in mice (5 mg/kg) at intraperitoneal dosage of 4 mg/kg of compound after 45 mins1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID122815Effect on 8-OH-DPAT-induced hypothermia in mice (5 mg/kg) at intraperitoneal dosage of 4 mg/kg of compound after 15 mins1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID180976Induction of behavioral syndrome(FT: forepaw treading) by the compound in reserpine pretreated rats at a dose of 4; FT mean score1999Journal of medicinal chemistry, Dec-02, Volume: 42, Issue:24
On the bioactive conformation of NAN-190 (1) and MP3022 (2), 5-HT(1A) receptor antagonists.
AID122844Effect on body temperature in mice at intraperitoneal dosage of 2 mg/kg, (compound administered 30 min before the test) after 60 min1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID180791Induction of behavioral syndrome(FBP: flat body posture) by the compound in reserpine pretreated rats at a dose of 4; FBP mean score1999Journal of medicinal chemistry, Dec-02, Volume: 42, Issue:24
On the bioactive conformation of NAN-190 (1) and MP3022 (2), 5-HT(1A) receptor antagonists.
AID122830Effect on body temperature in mice at intraperitoneal dosage of 1 mg/kg, (compound administered 30 min before the test) after 30 min1994Journal of medicinal chemistry, Aug-19, Volume: 37, Issue:17
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
AID184973Effect on 8-OH-DPAT-Induced LLR(lower lip retraction) in rats at a dose of 8 mg/kg; LLR score1999Journal of medicinal chemistry, Dec-02, Volume: 42, Issue:24
On the bioactive conformation of NAN-190 (1) and MP3022 (2), 5-HT(1A) receptor antagonists.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (4)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's3 (75.00)18.2507
2000's1 (25.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.02

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.02 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.21 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.02)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
8-hydroxy-2-(di-n-propylamino)tetralin
8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.. 8-OH-DPAT : A tetralin substituted at positions 1 and 7 by hydroxy and dipropylamino groups respectively		1.9810phenols;
tertiary amino compound;
tetralins		serotonergic antagonist
nan 190
1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine: RN from Toxlit. NAN 190 : An N-alkylpiperazine that consists of (2-methoxyphenyl)piperazine in which the amine hydrogen is substituted by a 4-(2-phthalimido)butyl group.		2.4220N-alkylpiperazine;
N-arylpiperazine;
phthalimides		serotonergic antagonist
reserpine
Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.. reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.		1.9810alkaloid ester;
methyl ester;
yohimban alkaloid		adrenergic uptake inhibitor;
antihypertensive agent;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
environmental contaminant;
first generation antipsychotic;
plant metabolite;
xenobiotic
triazoles
Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.		2.91401,2,3-triazole
ConditionIndicatedRelationship StrengthStudiesTrials