Page last updated: 2024-12-04

croconazole

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

croconazole: RN & structure given from first source for parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID2880
CHEMBL ID27289
CHEBI ID3920
SCHEMBL ID34369
MeSH IDM0114646

Synonyms (38)

Synonym
c18h15cln2o
croconazole (inn)
D07752
croconazole
77175-51-0
cloconazole
1[1-2[(3-chlorophenyl)methoxy]-phenyl]vinyl]-1h-imidazole
1-[1-[2-[(3-chlorophenyl)methoxy]phenyl]vinyl]imidazole
CHEMBL27289
chebi:3920 ,
1-[1-[2-[(3-chlorophenyl)methoxy]phenyl]ethenyl]imidazole
croconazolum [latin]
unii-446254h55g
446254h55g ,
croconazol [french,spanish]
1h-imidazole, 1-(1-(2-((3-chlorophenyl)methoxy)phenyl)ethenyl)-
croconazole [inn]
croconazolum
croconazol
1-(1-(o-((m-chlorobenzyl)oxy)phenyl)vinyl)imidazole
AKOS016013970
FT-0603175
croconazole [mi]
1-(1-(2-((3-chlorophenyl)methoxy)phenyl)ethenyl)-1h-imidazole
croconazole [who-dd]
SCHEMBL34369
DTXSID6058475
viniconazole
1-(1-(2-((3-chlorobenzyl)oxy)phenyl)vinyl)-1h-imidazole
WHPAGCJNPTUGGD-UHFFFAOYSA-N
3-chlorobenzyl 2-[1-(1h-imidazol-1-yl)vinyl]phenyl ether #
1-[1-[o-[(m-chlorobenzyl)oxy]phenyl]vinyl]imidazole
1-(1-(2-(3-chlorobenzyloxy)phenyl)vinyl)-1h-imidazole
Q5187423
1h-imidazole, 1-[1-[2-[(3-chlorophenyl)methoxy]phenyl]ethenyl]-
1-(1h-imidazole-1-yl)-1-[2-(3-chlorobenzyloxy)phenyl]ethene
A917322
1h-imidazole, 1-[1-[2-[(3-chlorophenyl)methoxy]phenyl]-

Research Excerpts

Overview

Croconazole hydrochloride is a new antifungal agent of the imidazole type.

ExcerptReferenceRelevance
"Croconazole hydrochloride is a new antifungal agent of the imidazole type. "( Croconazole in the treatment of tinea pedis.
Beierdörffer, H; Kehr, K; Michel, G,
)
3.02

Dosage Studied

At 10 mg/kg dosing of croconazole the elimination rate of the unchanged drug from plasma was faster in male than in female rats.

ExcerptRelevanceReference
" At 10 mg/kg dosing of croconazole the elimination rate of the unchanged drug from plasma was faster in male than in female rats."( Croconazole metabolism in rats.
Kawahara, S; Mizojiri, K; Nakano, M; Takeuchi, M, 1990
)
2.03
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (4)

ClassDescription
imidazole antifungal drugAny imidazole antifungal agent that has been used for the treatment of fungal infections in humans or animals.
conazole antifungal drugAny conazole antifungal agent that has been used for the treatment of fungal infections in animals or humans.
monochlorobenzenesAny member of the class of chlorobenzenes containing a mono- or poly-substituted benzene ring in which only one substituent is chlorine.
aromatic etherAny ether in which the oxygen is attached to at least one aryl substituent.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (12)

Assay IDTitleYearJournalArticle
AID39831Minimum inhibitory concentration (MIC) against Aspergillus fumigatus1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Synthesis and antifungal activity of new 1-vinylimidazoles.
AID214274Minimum inhibitory concentration against Trichophyton mentagrophytes IFO 58091987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Synthesis and antifungal activity of new 1-vinylimidazoles.
AID211165Minimum inhibitory concentration against Trichophyton asteroides1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Synthesis and antifungal activity of new 1-vinylimidazoles.
AID214427Minimum inhibitory concentration against Trichophyton rubrum IFO 54671987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Synthesis and antifungal activity of new 1-vinylimidazoles.
AID48588Minimum inhibitory concentration against Candida albicans IFO 13881987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Synthesis and antifungal activity of new 1-vinylimidazoles.
AID211162Antifungal activity against Trichophyton asteroides was determined in vitro1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Synthesis and antifungal activity of a series of novel 1,2-disubstituted propenones.
AID44958Antifungal activity against Candida albicans was determined in vitro1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Synthesis and antifungal activity of a series of novel 1,2-disubstituted propenones.
AID214275Minimum inhibitory concentration against Trichophyton mentagrophytes IFO 58101987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Synthesis and antifungal activity of new 1-vinylimidazoles.
AID48587Minimum inhibitory concentration against Candida albicans IFO 10601987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Synthesis and antifungal activity of new 1-vinylimidazoles.
AID39670Antifungal activity against Aspergillus fumigatus was determined in vitro1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Synthesis and antifungal activity of a series of novel 1,2-disubstituted propenones.
AID48576Minimum inhibitory concentration (MIC) against Candida albicans1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Synthesis and antifungal activity of new 1-vinylimidazoles.
AID214428Minimum inhibitory concentration against Trichophyton rubrum IFO 58071987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Synthesis and antifungal activity of new 1-vinylimidazoles.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (20)

TimeframeStudies, This Drug (%)All Drugs %
pre-19905 (25.00)18.7374
1990's9 (45.00)18.2507
2000's1 (5.00)29.6817
2010's4 (20.00)24.3611
2020's1 (5.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 20.86

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index20.86 (24.57)
Research Supply Index3.18 (2.92)
Research Growth Index4.74 (4.65)
Search Engine Demand Index18.60 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (20.86)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies3 (13.04%)4.05%
Observational0 (0.00%)0.25%
Other20 (86.96%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]