Page last updated: 2024-12-04
croconazole
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
croconazole: RN & structure given from first source for parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
ID Source | ID |
---|---|
PubMed CID | 2880 |
CHEMBL ID | 27289 |
CHEBI ID | 3920 |
SCHEMBL ID | 34369 |
MeSH ID | M0114646 |
Synonyms (38)
Synonym |
---|
c18h15cln2o |
croconazole (inn) |
D07752 |
croconazole |
77175-51-0 |
cloconazole |
1[1-2[(3-chlorophenyl)methoxy]-phenyl]vinyl]-1h-imidazole |
1-[1-[2-[(3-chlorophenyl)methoxy]phenyl]vinyl]imidazole |
CHEMBL27289 |
chebi:3920 , |
1-[1-[2-[(3-chlorophenyl)methoxy]phenyl]ethenyl]imidazole |
croconazolum [latin] |
unii-446254h55g |
446254h55g , |
croconazol [french,spanish] |
1h-imidazole, 1-(1-(2-((3-chlorophenyl)methoxy)phenyl)ethenyl)- |
croconazole [inn] |
croconazolum |
croconazol |
1-(1-(o-((m-chlorobenzyl)oxy)phenyl)vinyl)imidazole |
AKOS016013970 |
FT-0603175 |
croconazole [mi] |
1-(1-(2-((3-chlorophenyl)methoxy)phenyl)ethenyl)-1h-imidazole |
croconazole [who-dd] |
SCHEMBL34369 |
DTXSID6058475 |
viniconazole |
1-(1-(2-((3-chlorobenzyl)oxy)phenyl)vinyl)-1h-imidazole |
WHPAGCJNPTUGGD-UHFFFAOYSA-N |
3-chlorobenzyl 2-[1-(1h-imidazol-1-yl)vinyl]phenyl ether # |
1-[1-[o-[(m-chlorobenzyl)oxy]phenyl]vinyl]imidazole |
1-(1-(2-(3-chlorobenzyloxy)phenyl)vinyl)-1h-imidazole |
Q5187423 |
1h-imidazole, 1-[1-[2-[(3-chlorophenyl)methoxy]phenyl]ethenyl]- |
1-(1h-imidazole-1-yl)-1-[2-(3-chlorobenzyloxy)phenyl]ethene |
A917322 |
1h-imidazole, 1-[1-[2-[(3-chlorophenyl)methoxy]phenyl]- |
Research Excerpts
Overview
Croconazole hydrochloride is a new antifungal agent of the imidazole type.
Excerpt | Reference | Relevance |
---|---|---|
"Croconazole hydrochloride is a new antifungal agent of the imidazole type. " | ( Croconazole in the treatment of tinea pedis. Beierdörffer, H; Kehr, K; Michel, G, ) | 3.02 |
Dosage Studied
At 10 mg/kg dosing of croconazole the elimination rate of the unchanged drug from plasma was faster in male than in female rats.
Excerpt | Relevance | Reference |
---|---|---|
" At 10 mg/kg dosing of croconazole the elimination rate of the unchanged drug from plasma was faster in male than in female rats." | ( Croconazole metabolism in rats. Kawahara, S; Mizojiri, K; Nakano, M; Takeuchi, M, 1990) | 2.03 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Drug Classes (4)
Class | Description |
---|---|
imidazole antifungal drug | Any imidazole antifungal agent that has been used for the treatment of fungal infections in humans or animals. |
conazole antifungal drug | Any conazole antifungal agent that has been used for the treatment of fungal infections in animals or humans. |
monochlorobenzenes | Any member of the class of chlorobenzenes containing a mono- or poly-substituted benzene ring in which only one substituent is chlorine. |
aromatic ether | Any ether in which the oxygen is attached to at least one aryl substituent. |
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Bioassays (12)
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID39831 | Minimum inhibitory concentration (MIC) against Aspergillus fumigatus | 1987 | Journal of medicinal chemistry, Aug, Volume: 30, Issue:8 | Synthesis and antifungal activity of new 1-vinylimidazoles. |
AID214274 | Minimum inhibitory concentration against Trichophyton mentagrophytes IFO 5809 | 1987 | Journal of medicinal chemistry, Aug, Volume: 30, Issue:8 | Synthesis and antifungal activity of new 1-vinylimidazoles. |
AID211165 | Minimum inhibitory concentration against Trichophyton asteroides | 1987 | Journal of medicinal chemistry, Aug, Volume: 30, Issue:8 | Synthesis and antifungal activity of new 1-vinylimidazoles. |
AID214427 | Minimum inhibitory concentration against Trichophyton rubrum IFO 5467 | 1987 | Journal of medicinal chemistry, Aug, Volume: 30, Issue:8 | Synthesis and antifungal activity of new 1-vinylimidazoles. |
AID48588 | Minimum inhibitory concentration against Candida albicans IFO 1388 | 1987 | Journal of medicinal chemistry, Aug, Volume: 30, Issue:8 | Synthesis and antifungal activity of new 1-vinylimidazoles. |
AID211162 | Antifungal activity against Trichophyton asteroides was determined in vitro | 1987 | Journal of medicinal chemistry, Aug, Volume: 30, Issue:8 | Synthesis and antifungal activity of a series of novel 1,2-disubstituted propenones. |
AID44958 | Antifungal activity against Candida albicans was determined in vitro | 1987 | Journal of medicinal chemistry, Aug, Volume: 30, Issue:8 | Synthesis and antifungal activity of a series of novel 1,2-disubstituted propenones. |
AID214275 | Minimum inhibitory concentration against Trichophyton mentagrophytes IFO 5810 | 1987 | Journal of medicinal chemistry, Aug, Volume: 30, Issue:8 | Synthesis and antifungal activity of new 1-vinylimidazoles. |
AID48587 | Minimum inhibitory concentration against Candida albicans IFO 1060 | 1987 | Journal of medicinal chemistry, Aug, Volume: 30, Issue:8 | Synthesis and antifungal activity of new 1-vinylimidazoles. |
AID39670 | Antifungal activity against Aspergillus fumigatus was determined in vitro | 1987 | Journal of medicinal chemistry, Aug, Volume: 30, Issue:8 | Synthesis and antifungal activity of a series of novel 1,2-disubstituted propenones. |
AID48576 | Minimum inhibitory concentration (MIC) against Candida albicans | 1987 | Journal of medicinal chemistry, Aug, Volume: 30, Issue:8 | Synthesis and antifungal activity of new 1-vinylimidazoles. |
AID214428 | Minimum inhibitory concentration against Trichophyton rubrum IFO 5807 | 1987 | Journal of medicinal chemistry, Aug, Volume: 30, Issue:8 | Synthesis and antifungal activity of new 1-vinylimidazoles. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (20)
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 5 (25.00) | 18.7374 |
1990's | 9 (45.00) | 18.2507 |
2000's | 1 (5.00) | 29.6817 |
2010's | 4 (20.00) | 24.3611 |
2020's | 1 (5.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 20.86
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (20.86) All Compounds (24.57) |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 3 (13.04%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 20 (86.96%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |