Pasteurellosis, Pneumonic

Bovine respiratory disease found in animals that have been shipped or exposed to CATTLE recently transported. The major agent responsible for the disease is MANNHEIMIA HAEMOLYTICA and less commonly, PASTEURELLA MULTOCIDA or HAEMOPHILUS SOMNUS. All three agents are normal inhabitants of the bovine nasal pharyngeal mucosa but not the LUNG. They are considered opportunistic pathogens following STRESS, PHYSIOLOGICAL and/or a viral infection. The resulting bacterial fibrinous BRONCHOPNEUMONIA is often fatal.

Synonyms(2)

Synonym
Pasteurellosis, Pneumonic
Shipping Fever

Research Excerpts

Overview

Excerpt	Reference
"Pneumonic pasteurellosis is an economically important infectious disease in the small ruminant industry which causes sudden death and loss for farmers."	( Abba, Y; Bitrus, AA; Chung, ELT; Jesse, FFA; Lila, MAM; Maslamany, D; Muniandy, KV; Norsidin, MJ; Tan, AHAR, 2019)

Treatment

Excerpt	Reference
"During the outbreak of shipping fever metrenperone showed effective antipyretic properties, and all the calves treated with it made a complete recovery."	( Close, R; Genicot, B; Lekeux, P; Lindsey, JK; Mouligneau, F; Rollin, F, 1993)
"When used to treat pneumonic pasteurellosis in calves, danofloxacin and enrofloxacin can be expected to deliver concentration-dependent bactericidal activity against M."	( Shostrom, VK; Skogerboe, TL; TerHune, TN; Weigel, DJ, 2005)

Research

Studies (142)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	17 (11.97)	23.3326
1990's	45 (31.69)	12.5806
2000's	59 (41.55)	18.1394
2010's	20 (14.08)	28.8240
2020's	1 (0.70)	9.53

Drug	Relationship Strength	Studies	Trials
lactic acid	low	1	0
formaldehyde	low	1	0
histamine	low	1	0
nitrites	low	1	0
palmitic acid	low	1	0
5,8,11,14-eicosatetraynoic acid	low	1	0
aztreonam	low	1	0
verapamil	low	1	0
ciprofloxacin	medium	3	1
clenbuterol	low	1	0
hydroxyurea	low	1	0
iodoacetamide	low	1	0
nifedipine	low	1	0
propranolol	low	1	0
sulfadimethoxine	low	1	0
sulfamethazine	low	1	0
sulfanilamide	low	1	0
fluprednisolone	low	1	0
penicillin g	low	1	0
chloramphenicol	low	1	0
carbostyril	medium	5	2
ampicillin	low	1	0
congo red	low	1	0
erythromycin	low	2	0
spectinomycin	low	2	0
flumethasone	low	1	0
mannose	low	2	0
streptomycin	low	3	0
acetylglucosamine	low	1	0
thiamphenicol	medium	8	7
tetradecanoylphorbol acetate	low	1	0
clonixin	low	1	0
amoxicillin	low	1	0
substance p	low	1	0
flunixin meglumine	low	1	0
difloxacin	medium	2	1
marbofloxacin	medium	1	1
cephalosporin c	medium	5	2
web 2086	low	1	0
triazoles	low	1	0
enrofloxacin	medium	4	1
danofloxacin	low	3	0
metrenperone	low	1	0
fibrinogen	low	2	0
u 73122	low	1	0
1-hexadecyl-2-acetyl-glycero-3-phosphocholine	low	1	0
florfenicol	medium	8	7
omega-n-methylarginine	low	2	0
depsidomycin	low	1	0
isoflupredone acetate	low	1	0
fibrin	low	3	0
epiglucan	low	1	0
laminaran	low	1	0
acriflavine	low	1	0
tiamulin	medium	1	1
alpha-chymotrypsin	low	1	0
dinoprostone	medium	1	1
leukotriene b4	low	1	0
morantel	low	1	0
cysteine	low	1	0
tulathromycin	medium	15	11
mocetinostat	low	2	0
g(m1) ganglioside	low	1	0
bimosiamose disodium	low	2	0
calcimycin	low	1	0
cecropin b protein, insecta	medium	1	1
ceftiofur	medium	5	2
tildipirosin	medium	1	1
piperidines	low	1	0
interleukin-8	medium	7	1
tilmicosin	medium	18	11
tylosin	medium	19	12
leukotoxin	medium	38	2
chlortetracycline	low	2	0
oxytetracycline, anhydrous	low	7	0
piroxicam	low	1	0
lactoferrin	low	3	0
thromboplastin	low	1	0
muramidase	low	1	0
exudates	low	1	0

Protein Targets (746)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	14	0	0	14
Chain A, Cruzipain	7	0	0	7
regulator of G-protein signaling 4	9	0	0	9
Platelet-activating factor receptor	0	3	0	4
Inositol monophosphatase 1	3	0	0	3
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	8	0	0	8
Chain A, 2-oxoglutarate Oxygenase	10	0	0	10
Chain A, ATP-DEPENDENT DNA HELICASE Q1	5	0	0	5
Chain A, Ferritin light chain	3	0	0	3
Luciferase	8	0	0	8
Mcl-1	0	1	0	1
phosphopantetheinyl transferase	5	0	0	5
Myeloid cell leukemia sequence 1 (BCL2-related)	0	1	0	1
Microtubule-associated protein tau	7	0	0	7
thioredoxin glutathione reductase	3	0	0	3
aldehyde dehydrogenase 1 family, member A1	13	0	0	13
envelope glycoprotein	0	1	0	1
core protein, partial	0	1	0	1
bromodomain adjacent to zinc finger domain 2B	6	0	0	6
euchromatic histone-lysine N-methyltransferase 2	16	0	0	16
Bloom syndrome protein isoform 1	6	0	0	6
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	9	0	0	9
glyceraldehyde-3-phosphate dehydrogenase isoform 1	0	1	0	1
DNA polymerase beta	4	0	0	4
ubiquitin carboxyl-terminal hydrolase 2 isoform a	5	0	0	5
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	2	0	2
eukaryotic translation initiation factor 4E isoform 1	0	2	0	2
geminin	16	0	0	16
DNA polymerase kappa isoform 1	9	0	0	9
Vif	0	1	0	1
Tat	0	1	0	1
survival motor neuron protein isoform d	5	0	0	5
histone acetyltransferase KAT2A isoform 1	9	0	0	9
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	1	0	2
dual specificity protein phosphatase 6	0	1	0	1
POsterior Segregation	0	0	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
bcl-2-like protein 1 isoform Bcl-X(L)	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Caspase-1	0	1	0	1
Zinc finger protein mex-5	0	0	0	1
ATP-dependent phosphofructokinase	7	0	0	7
Putative glycosyltransferase WbgO	0	0	0	1
Cytochrome P450 3A4	0	10	1	11
Cannabinoid receptor 1	0	1	0	1
Killer cell lectin-like receptor subfamily B member 1A	0	1	0	1
Early activation antigen CD69	0	1	0	1
acetylcholinesterase	7	0	0	7
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
RAR-related orphan receptor gamma	13	0	0	13
SMAD family member 2	4	0	0	4
Fumarate hydratase	5	0	0	5
SMAD family member 3	4	0	0	4
TDP1 protein	19	0	0	19
GLI family zinc finger 3	12	0	0	12
AR protein	18	0	0	18
caspase 7, apoptosis-related cysteine protease	1	0	0	1
estrogen receptor 2 (ER beta)	3	0	0	3
nuclear receptor subfamily 1, group I, member 3	9	0	0	9
progesterone receptor	7	0	0	7
cytochrome P450 family 3 subfamily A polypeptide 4	10	0	0	10
glucocorticoid receptor [Homo sapiens]	9	0	0	9
retinoic acid nuclear receptor alpha variant 1	12	0	0	12
retinoid X nuclear receptor alpha	7	0	0	7
estrogen-related nuclear receptor alpha	17	0	0	17
farnesoid X nuclear receptor	7	0	0	7
pregnane X nuclear receptor	12	0	0	12
estrogen nuclear receptor alpha	27	0	0	27
cytochrome P450 2D6	8	0	0	8
polyprotein	5	0	0	5
67.9K protein	3	0	0	3
peroxisome proliferator-activated receptor delta	4	0	0	4
peroxisome proliferator activated receptor gamma	6	0	0	6
vitamin D (1,25- dihydroxyvitamin D3) receptor	5	0	0	5
caspase-3	1	0	0	1
aryl hydrocarbon receptor	8	0	0	8
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	10	0	0	10
thyroid stimulating hormone receptor	8	0	0	8
activating transcription factor 6	5	0	0	5
thyrotropin-releasing hormone receptor	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	5	0	0	5
v-jun sarcoma virus 17 oncogene homolog (avian)	5	0	0	5
Histone H2A.x	4	0	0	4
potassium voltage-gated channel subfamily H member 2 isoform d	6	0	0	6
thyroid hormone receptor beta isoform 2	15	0	0	15
nuclear factor erythroid 2-related factor 2 isoform 1	9	0	0	9
Voltage-dependent calcium channel gamma-2 subunit	5	0	0	5
Interferon beta	7	0	0	7
Cellular tumor antigen p53	15	0	0	15
Glutamate receptor 2	5	0	0	5
Spike glycoprotein	5	0	0	5
ATPase family AAA domain-containing protein 5	4	0	0	4
Ataxin-2	7	0	0	7
Chain A, Beta-lactamase	6	0	0	6
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
apical membrane antigen 1, AMA1	5	0	0	5
Beta-lactamase	0	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
DNA polymerase eta isoform 1	3	0	0	3
DNA polymerase iota isoform a (long)	9	0	0	9
urokinase-type plasminogen activator precursor	4	0	0	4
plasminogen precursor	4	0	0	4
urokinase plasminogen activator surface receptor precursor	4	0	0	4
ATP-binding cassette sub-family C member 3	0	10	0	10
Multidrug resistance-associated protein 4	0	10	0	11
Bile salt export pump	0	5	0	5
Bile salt export pump	0	18	0	18
Beta-lactamase SHV-1	0	0	0	2
Beta-lactamase SHV-1	0	0	0	2
Cytochrome P450 2C9	0	7	0	7
Beta-lactamase	0	0	0	2
Kappa-type opioid receptor	0	1	0	3
Solute carrier family 15 member 1	0	4	0	4
Solute carrier family 15 member 1	0	2	0	2
Cytochrome P450 2J2	0	6	0	6
B2 metallo-beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	3	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	3	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Canalicular multispecific organic anion transporter 1	0	9	0	9
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Beta-lactamase	0	0	0	2
acid sphingomyelinase	3	0	0	3
GLS protein	8	0	0	8
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase type 2	0	0	0	2
Metallo-beta-lactamase VIM-11	0	0	0	2
Metallo-beta-lactamase VIM-2	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
chromobox protein homolog 1	10	0	0	10
Carbonic anhydrase 1	0	5	0	7
Carbonic anhydrase 2	0	6	1	11
60 kDa heat shock protein, mitochondrial	0	2	0	2
Beta-lactamase OXA-7	0	0	0	1
10 kDa heat shock protein, mitochondrial	0	2	0	2
Angiopoietin-1 receptor	0	0	1	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Thiosulfate sulfurtransferase	0	2	0	2
Metallo-beta-lactamase VIM-13	0	0	0	2
Efflux transporter	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase Toho-1	0	0	0	2
Beta-lactamase	0	0	0	2
Class D beta-lactamase	0	0	0	2
60 kDa chaperonin	0	2	0	2
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
10 kDa chaperonin	0	2	0	2
Metallo-b-lactamase	0	0	0	2
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	2
Histamine H3 receptor	0	1	0	2
Beta-lactamase class B VIM-2	0	0	0	2
Beta-lactamase VIM-1	0	0	0	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	5	0	0	5
Chain A, JmjC domain-containing histone demethylation protein 3A	4	0	0	4
endonuclease IV	1	0	0	1
glp-1 receptor, partial	3	0	0	3
thioredoxin reductase	11	0	0	11
ClpP	1	0	0	1
electroneutral potassium-chloride cotransporter KCC2	0	0	1	1
ATAD5 protein, partial	4	0	0	4
USP1 protein, partial	7	0	0	7
TSHR protein	1	0	0	1
Smad3	2	0	0	2
thyroid stimulating hormone receptor	6	0	0	6
nonstructural protein 1	4	0	0	4
glucocerebrosidase	3	0	0	3
Parkin	3	0	0	3
arylsulfatase A	4	0	0	4
LacZ protein (plasmid)	0	0	1	1
XBP1	0	1	0	1
IDH1	4	0	0	4
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	3	0	0	3
serine-protein kinase ATM isoform a	1	0	0	1
lysosomal alpha-glucosidase preproprotein	3	0	0	3
hexokinase-4 isoform 1	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
peripheral myelin protein 22 isoform 1	4	0	0	4
type-1 angiotensin II receptor	0	1	0	1
D(1A) dopamine receptor	3	0	0	3
vitamin D3 receptor isoform VDRA	10	0	0	10
nuclear factor erythroid 2-related factor 2 isoform 2	2	0	0	2
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
glucokinase regulatory protein	1	0	0	1
huntingtin isoform 2	2	0	0	2
mitogen-activated protein kinase 1	3	0	0	3
flap endonuclease 1	2	0	0	2
ras-related protein Rab-9A	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
serine/threonine-protein kinase PLK1	5	0	0	5
apelin receptor	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
DNA damage-inducible transcript 3 protein	0	1	0	1
nuclear receptor ROR-gamma isoform 1	6	0	0	6
Vpr	1	0	0	1
streptokinase A precursor	0	0	6	6
lamin isoform A-delta10	10	0	0	10
neuropeptide S receptor isoform A	1	0	0	1
Rap guanine nucleotide exchange factor 3	4	0	0	4
Amyloid-beta precursor protein	1	2	0	3
Alpha-synuclein	2	0	0	2
D(1A) dopamine receptor	1	0	0	1
Guanine nucleotide-binding protein G	2	0	0	2
TAR DNA-binding protein 43	4	0	0	4
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
heat shock protein 90, putative	0	0	0	1
Chain A, serum paraoxonase	0	1	0	1
Carbonic anhydrase 12	0	2	0	3
Carbonic anhydrase 3	0	2	0	3
Neutrophil cytosol factor 1	0	1	0	1
Carbonic anhydrase 4	0	4	0	5
Carbonic anhydrase 6	0	3	0	4
Carbonic anhydrase 5A, mitochondrial	0	4	0	6
Carbonic anhydrase 7	0	2	0	3
Carbonic anhydrase 9	0	4	0	6
Carbonic anhydrase 13	0	2	0	3
Poly [ADP-ribose] polymerase tankyrase-2	0	1	0	1
Carbonic anhydrase 14	0	2	0	3
Carbonic anhydrase 5B, mitochondrial	0	2	0	4
interleukin 8	2	0	0	2
EWS/FLI fusion protein	9	0	0	9
G	5	0	0	5
heat shock protein beta-1	2	0	0	2
lethal factor (plasmid)	2	0	0	2
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
HLA class I histocompatibility antigen, B alpha chain	5	0	0	5
30S ribosomal protein S6	0	3	2	5
30S ribosomal protein S7	0	3	2	5
50S ribosomal protein L15	0	3	2	5
50S ribosomal protein L10	0	3	2	5
50S ribosomal protein L11	0	3	2	5
50S ribosomal protein L7/L12	0	3	2	5
50S ribosomal protein L19	0	3	2	5
50S ribosomal protein L1	0	3	2	5
50S ribosomal protein L20	0	3	2	5
50S ribosomal protein L27	0	3	2	5
50S ribosomal protein L28	0	3	2	5
50S ribosomal protein L29	0	3	2	5
50S ribosomal protein L31	0	3	2	5
50S ribosomal protein L31 type B	0	3	2	5
50S ribosomal protein L32	0	3	2	5
50S ribosomal protein L33	0	3	2	5
50S ribosomal protein L34	0	3	2	5
50S ribosomal protein L35	0	3	2	5
50S ribosomal protein L36	0	3	2	5
30S ribosomal protein S10	0	3	2	5
30S ribosomal protein S11	0	3	2	5
30S ribosomal protein S12	0	3	2	5
30S ribosomal protein S13	0	3	2	5
30S ribosomal protein S16	0	3	2	5
30S ribosomal protein S18	0	3	2	5
30S ribosomal protein S19	0	3	2	5
30S ribosomal protein S20	0	3	2	5
30S ribosomal protein S2	0	3	2	5
30S ribosomal protein S3	0	3	2	5
30S ribosomal protein S4	0	3	2	5
30S ribosomal protein S5	0	3	2	5
30S ribosomal protein S8	0	3	2	5
30S ribosomal protein S9	0	3	2	5
50S ribosomal protein L13	0	3	2	5
50S ribosomal protein L14	0	3	2	5
50S ribosomal protein L16	0	3	2	5
50S ribosomal protein L23	0	3	2	5
30S ribosomal protein S15	0	3	2	5
50S ribosomal protein L17	0	3	2	5
50S ribosomal protein L21	0	3	2	5
50S ribosomal protein L30	0	3	2	5
50S ribosomal protein L6	0	3	2	5
30S ribosomal protein S14	0	3	2	5
30S ribosomal protein S17	0	3	2	5
30S ribosomal protein S1	0	3	2	5
50S ribosomal protein L18	0	3	2	5
50S ribosomal protein L2	0	3	2	5
50S ribosomal protein L3	0	3	2	5
50S ribosomal protein L24	0	3	2	5
50S ribosomal protein L4	0	3	2	5
50S ribosomal protein L22	0	3	2	5
50S ribosomal protein L5	0	3	2	5
30S ribosomal protein S21	0	3	2	5
50S ribosomal protein L25	0	3	2	5
50S ribosomal protein L36 2	0	3	2	5
Inositol hexakisphosphate kinase 1	5	0	0	5
Methionine--tRNA ligase, mitochondrial	0	0	1	1
cytochrome P450 2C9, partial	5	0	0	5
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Protein-arginine deiminase type-4	0	4	0	4
Chain A, HADH2 protein	4	0	0	4
Chain B, HADH2 protein	4	0	0	4
cytochrome P450 2C9 precursor	4	0	0	4
Gamma-aminobutyric acid receptor subunit pi	7	2	1	10
Cytochrome P450 1A2	0	3	0	3
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	2
DNA gyrase subunit A	0	1	0	3
DNA gyrase subunit B	0	1	0	3
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	1	0	2
Cytochrome P450 2D6	0	3	0	3
DNA topoisomerase 2-alpha	0	1	0	4
Gamma-aminobutyric acid receptor subunit beta-1	7	2	1	10
Gamma-aminobutyric acid receptor subunit delta	7	2	1	10
Gamma-aminobutyric acid receptor subunit gamma-2	7	2	1	10
Gamma-aminobutyric acid receptor subunit alpha-5	7	2	1	10
Gamma-aminobutyric acid receptor subunit alpha-3	7	2	1	10
DNA gyrase subunit A	0	1	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	7	2	1	10
Gamma-aminobutyric acid receptor subunit alpha-2	7	2	1	10
Gamma-aminobutyric acid receptor subunit alpha-4	7	2	1	10
Gamma-aminobutyric acid receptor subunit gamma-3	7	2	1	10
Gamma-aminobutyric acid receptor subunit alpha-6	7	2	1	10
Cytochrome P450 2C19	0	3	0	3
Multidrug resistance protein MdtK	0	0	1	1
Histamine H2 receptor	5	0	1	6
Gamma-aminobutyric acid receptor subunit alpha-1	7	2	1	10
Gamma-aminobutyric acid receptor subunit beta-3	7	2	1	10
Gamma-aminobutyric acid receptor subunit beta-2	7	2	1	10
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	2
Potassium voltage-gated channel subfamily H member 2	0	7	0	8
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Integrase	0	1	0	1
GABA theta subunit	7	2	1	10
Gamma-aminobutyric acid receptor subunit epsilon	7	2	1	10
peripheral myelin protein 22	5	0	0	5
Beta-2 adrenergic receptor	0	4	2	6
Beta-1 adrenergic receptor	0	4	1	5
5-hydroxytryptamine receptor 1A	0	7	1	9
5-hydroxytryptamine receptor 1B	0	6	0	6
Delta-type opioid receptor	0	1	1	2
Beta-2 adrenergic receptor	0	0	1	3
Beta-2 adrenergic receptor	0	1	2	5
UDP-glucuronosyltransferase 2B7	0	0	0	1
UDP-glucuronosyltransferase 1A3	0	0	0	1
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	1	0	1
B2 bradykinin receptor	0	1	0	1
Dihydrofolate reductase	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Chymotrypsinogen A	0	0	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	0	0	2
5-hydroxytryptamine receptor 2A	0	3	0	4
Beta-galactosidase	0	1	0	2
Choline O-acetyltransferase	0	1	0	1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	0	2	0	2
PH domain leucine-rich repeat-containing protein phosphatase 2	0	1	0	1
Chymotrypsin-C	0	1	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
prostaglandin E2 receptor EP2 subtype	1	0	0	1
Solute carrier family 22 member 2	0	0	0	2
Solute carrier family 22 member 1	0	3	0	5
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	2	1	3
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin F2-alpha receptor	0	0	1	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP3 subtype	0	2	1	3
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Prostacyclin receptor	0	2	1	3
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier family 22 member 6	0	2	0	3
Solute carrier family 22 member 7	0	0	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 8	0	2	0	3
Solute carrier family 22 member 6	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier family 22 member 11	0	1	0	2
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Motilin receptor	0	0	1	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
Motilin receptor	0	1	1	2
Albumin	0	0	3	3
ATP-dependent translocase ABCB1	0	3	0	3
ATP-dependent translocase ABCB1	0	7	1	15
60 kDa chaperonin	0	1	0	1
Chitinase B	0	1	0	1
ATP-dependent translocase ABCB1	0	3	0	4
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Cytochrome P450 1B1	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
transcriptional regulator ERG isoform 3	4	0	0	4
twin arginine protein translocation system - TatA protein	0	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
nuclear receptor subfamily 1, group I, member 2	5	0	0	5
glycogen synthase kinase-3 alpha	0	0	0	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
GALC protein	1	0	0	1
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Solute carrier family 22 member 3	0	1	0	2
Plasma kallikrein	0	0	0	1
Macrophage migration inhibitory factor	0	2	0	2
Histamine H2 receptor	0	3	2	5
Adenosine receptor A1	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	1
Adenosine receptor A2a	0	1	0	2
Histamine H1 receptor	0	1	2	3
Histamine H1 receptor	0	2	1	3
Metabotropic glutamate receptor 5	0	1	1	2
Histamine H1 receptor	0	2	2	4
Glutamate receptor ionotropic, NMDA 1	0	0	0	1
Carbonic anhydrase	0	2	0	3
Carbonic anhydrase	0	1	0	3
Histamine H3 receptor	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	0	1
Glutamate receptor ionotropic, NMDA 2B	0	0	0	1
Glutamate receptor ionotropic, NMDA 2C	0	0	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase-like protein, putative	0	0	0	1
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase	0	1	0	3
Glutamate receptor ionotropic, NMDA 2D	0	0	0	1
Solute carrier family 22 member 1	0	1	0	2
Carbonic anhydrase	0	1	0	3
Equilibrative nucleoside transporter 4	0	0	0	1
Glutamate receptor ionotropic, NMDA 3B	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carbonic anhydrase 4	0	1	0	2
Carbonic anhydrase 15	0	2	0	3
Carbonic anhydrase 13	0	1	0	2
Histamine H4 receptor	0	1	2	3
Carboxylic ester hydrolase	0	0	0	1
Solute carrier family 22 member 2	0	1	0	2
Glutamate receptor ionotropic, NMDA 3A	0	0	0	1
Histamine H3 receptor	0	1	2	3
NFKB1 protein, partial	3	0	0	3
cytochrome P450 3A4 isoform 1	7	0	0	7
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Stromelysin-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Urease subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Ribonucleoside-diphosphate reductase large subunit	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Urease subunit beta	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
15-lipoxygenase, partial	3	0	0	3
Thrombopoietin	2	0	0	2
hypothetical protein, conserved	2	0	0	2
alpha-galactosidase	1	0	0	1
cellular tumor antigen p53 isoform a	3	0	0	3
cytochrome P450 2C19 precursor	4	0	0	4
histone deacetylase 9 isoform 3	1	0	0	1
M-phase phosphoprotein 8	2	0	0	2
muscarinic acetylcholine receptor M1	3	0	0	3
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Alcohol dehydrogenase E chain	0	1	0	1
Alcohol dehydrogenase S chain	0	1	0	1
Integrin beta-3	3	0	0	3
Integrin alpha-IIb	3	0	0	3
Disintegrin and metalloproteinase domain-containing protein 17	3	0	0	3
Leukotriene B4 receptor 1	0	2	0	3
Leukotriene B4 receptor 2	0	1	0	2
Alpha-mannosidase 2C1	0	1	0	1
Fucose-binding lectin PA-IIL	0	1	0	1
CD209 antigen	0	1	0	1
PPM1D protein	1	0	0	1
Histone deacetylase 3	0	2	0	2
Nuclear receptor corepressor 1	0	1	0	1
Integrin beta-1	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Integrin alpha-4	0	1	0	1
Histone deacetylase 4	0	1	0	1
Histone deacetylase 1	0	2	0	2
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	2	0	2
Histone deacetylase 11	0	1	0	1
Histone deacetylase 8	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 5	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
pregnane X receptor	1	0	0	1
beta-2 adrenergic receptor	1	0	0	1
cytochrome P450 2D6 isoform 1	2	0	0	2
tumor necrosis factor	1	0	0	1
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
eyes absent homolog 2 isoform a	1	0	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
muscleblind-like protein 1 isoform 1	3	0	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1F	0	3	0	3
5-hydroxytryptamine receptor 4	0	6	0	6
Potassium channel subfamily K member 2	0	0	1	1
Glutathione reductase, mitochondrial	0	2	0	2
Muscarinic acetylcholine receptor M2	0	1	1	3
Muscarinic acetylcholine receptor M4	0	0	0	1
Muscarinic acetylcholine receptor M5	0	0	0	1
Adenosine receptor A3	0	3	1	4
Muscarinic acetylcholine receptor M1	0	1	1	3
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Phospholipase A2, membrane associated	0	0	0	1
Alpha-1B adrenergic receptor	0	3	1	4
Muscarinic acetylcholine receptor M3	0	1	1	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Thromboxane-A synthase	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
5-hydroxytryptamine receptor 2C	0	6	1	7
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Adenosine receptor A2a	0	2	1	3
Adenosine receptor A1	0	2	0	2
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
C-C chemokine receptor type 2	0	2	0	2
Alpha-1A adrenergic receptor	0	3	1	4
Nuclear receptor ROR-gamma	1	0	0	1
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Potassium voltage-gated channel subfamily A member 1	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	4	0	5
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	3	0	3
Myosin light chain kinase, smooth muscle	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Potassium channel subfamily K member 2	0	1	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Sodium channel protein type 11 subunit alpha	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	1	3
Sodium channel protein type 8 subunit alpha	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	0	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	2
Neutrophil elastase	0	1	0	1
Proteinase-activated receptor 1	0	1	0	1
Nitric oxide synthase, endothelial	0	1	0	1
Nitric oxide synthase, endothelial	0	2	0	2
Nitric oxide synthase, brain	0	2	0	2
Nitric oxide synthase, brain	0	2	0	2
Nitric oxide synthase, inducible	0	1	0	1
Nitric oxide synthase, inducible	0	2	0	2
Collagenase 3	0	1	0	1
Nitric oxide synthase, brain	0	1	0	1
WRN	1	0	0	1
Valosin-containing protein	0	1	0	1
thyroid hormone receptor beta isoform a	1	0	0	1
microphthalmia-associated transcription factor isoform 9	0	1	0	1
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
phosphoglycerate kinase	1	0	0	1
Chain A, Fatty acid-binding protein, adipocyte	0	1	0	1
Acetylcholinesterase	0	1	0	1
Toll-like receptor 2	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Fatty acid-binding protein, intestinal	0	1	0	1
Fatty acid-binding protein, adipocyte	0	2	1	3
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Fatty acid-binding protein 5	0	2	1	3
Peroxisome proliferator-activated receptor alpha	1	0	1	2
Olfactory receptor 51E2	0	0	1	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 6	0	2	0	2
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	1	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase 1	0	0	0	1
Beta-lactamase OXA-10	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase TEM	0	1	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	1
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	1	0	2
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Beta-1 adrenergic receptor	0	1	1	3
5-hydroxytryptamine receptor 1A	0	1	0	1
Alpha-2A adrenergic receptor	0	3	2	6
Beta-2 adrenergic receptor	0	2	0	3
Cytochrome P450 2C8	0	2	0	2
Beta-3 adrenergic receptor	0	2	1	3
D(2) dopamine receptor	0	1	1	2
Alpha-2B adrenergic receptor	0	0	1	2
Beta-1 adrenergic receptor	0	3	1	5
Alpha-2C adrenergic receptor	0	1	2	4
D(3) dopamine receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	0	1	1
D(1A) dopamine receptor	0	1	1	2
Alpha-2C adrenergic receptor	0	0	1	1
Alpha-2A adrenergic receptor	0	0	1	1
Alpha-1D adrenergic receptor	0	1	1	2
Alpha-1D adrenergic receptor	0	0	1	2
Endothelin-1 receptor	0	1	1	2
Beta-3 adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	1	3
5-hydroxytryptamine receptor 2A	0	4	1	5
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Sodium-dependent serotonin transporter	0	4	0	4
Cholecystokinin receptor type A	0	1	1	2
5-hydroxytryptamine receptor 7	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	2	4
Alpha-1B adrenergic receptor	0	0	1	2
Mu-type opioid receptor	0	1	1	2
Vasopressin V1a receptor	0	1	1	2
Delta-type opioid receptor	0	1	1	2
Kappa-type opioid receptor	0	1	1	2
5-hydroxytryptamine receptor 2B	0	4	1	5
5-hydroxytryptamine receptor 6	0	4	1	5
5-hydroxytryptamine receptor 7	0	2	0	2
Beta-2 adrenergic receptor	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	2	0	2
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
Substance-P receptor	0	2	0	2
Neuromedin-K receptor	0	0	1	1
Substance-K receptor	0	1	1	2
Substance-K receptor	0	2	0	2
Substance-P receptor	0	2	1	3
Neuromedin-K receptor	0	1	1	2
Substance-P receptor	0	1	0	1
Substance-K receptor	0	1	0	1
D(2) dopamine receptor	0	1	1	2
Substance-K receptor	0	1	0	1
Growth hormone secretagogue receptor type 1	0	0	1	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2	0	1	1	2
Cholinesterase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
Acetylcholinesterase	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Protein argonaute-2	0	0	1	1
Serine/threonine-protein kinase D3	0	0	1	1
Protein kinase C gamma type	0	1	1	2
Protein kinase C beta type	0	1	1	2
Luciferin 4-monooxygenase	0	0	1	1
Protein kinase C alpha type	0	1	1	2
Protein kinase C eta type	0	0	1	1
Protein kinase C iota type	0	0	1	1
Protein kinase C epsilon type	0	1	1	2
Protein kinase C theta type	0	0	1	1
Protein kinase C zeta type	0	0	1	1
Protein kinase C delta type	0	1	1	2
Serine/threonine-protein kinase D1	0	0	1	1
Ras guanyl-releasing protein 3	0	0	1	1
Estrogen receptor	0	0	1	1
Estrogen receptor beta	0	0	1	1
Telomerase reverse transcriptase	0	1	0	1
Glycoprotein	0	1	0	1
Muscarinic acetylcholine receptor M2	0	0	1	1
Catechol O-methyltransferase	0	1	0	1
Potassium voltage-gated channel subfamily A member 3	0	1	0	1
Multidrug resistance-associated protein 1	0	2	1	4
D(3) dopamine receptor	0	2	0	2
Chloroquine resistance transporter	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	2	0	2
Platelet-activating factor receptor	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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