Compounds > triazoles
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triazoles and Cancer of Prostate

triazoles has been researched along with Cancer of Prostate in 72 studies

Research

Studies (72)

TimeframeStudies, this research(%)All Research%
pre-19901 (1.39)18.7374
1990's4 (5.56)18.2507
2000's17 (23.61)29.6817
2010's42 (58.33)24.3611
2020's8 (11.11)2.80

Authors

AuthorsStudies
Asim, M; Ateeq, B; Bhatia, V; Biswas, T; Carskadon, S; Goel, S; Gupta, N; Kundu, S; Morrissey, C; Palanisamy, N1
Ampomah-Wireko, M; Cao, Y; Obaid Arhema Frejat, F; Wang, H; Wu, C; Wu, G; Yang, P; Yang, Y; Yuan, Q; Zhai, H; Zhang, S1
Albuquerque, HMT; Helguero, LA; Monteiro, FL; Rocha, DHA; Saher, L; Silva, AMS1
Kao, CY; Tsai, MJ; Tsai, SY; Wang, L; Xu, M1
Dai, T; Evers, BM; Qiu, Z; Wang, J; Wang, S; Wu, Y; Yang, X; Yu, Q1
Agata, Y; Kageyama, S; Kawamoto, H; Kawauchi, A; Kondo, K; Miyazaki, K; Miyazaki, M; Motooka, D; Nagasawa, M; Okuzaki, D; Terada, K; Tomimatsu, K; Yoshida, T1
Afzal, M; Ahmed, K; Kren, BT; Naveed, AK; Trembley, JH1
Carneiro, JWM; Filho, EV; Fiorot, RG; Freitas, MCR; Greco, SJ; Guimarães, ARA; Loureiro, LB; Muri, EMF; Pessôa, JC; Pinheiro, EMC; Pinheiro, S; Rocha-Brito, KJP; Rotamiro, KM; Silva Junior, CMD1
Dalmau, E; Fernández-Morales, LA; Marín, M; Martinez Vila, C; Oliveres, H; Pardo, JC; Ribera, P; Segui, MA1
Armstrong, A; De, W; Lin, JZ; Wang, ZJ; Wu, HF; Xu, WZ; Zheng, M; Zhu, JG1
Beltran, H; Demichelis, F; Rickman, DS; Rubin, MA1
Barbieri, CE; Beca, F; Beck, AH; Blattner, M; Bradner, JE; Buckley, DL; Buser, L; Chen, T; Chen, Y; Dai, X; Gan, W; Garraway, LA; Guo, J; Huang, J; Huang, L; Inuzuka, H; Li, X; Liu, P; Liu, S; Muthuswamy, SK; Qi, J; Rubin, MA; Shimizu, K; Vasudevan, D; Wang, L; Wang, S; Wei, W; Wild, PJ; Wong, KK; Zhang, J; Zhang, W; Zhong, Q1
Bellini, E; Berchuck, A; Bernasocchi, T; Bertoni, F; Bielski, CM; Broaddus, RR; Carney, ME; Carr, SA; Cascione, L; Catapano, CV; Civenni, G; El Tekle, G; Enchev, RI; Garraway, LA; Janouskova, H; Kryukov, GV; Losa, M; Moch, H; Mutch, DG; Napoli, S; Peter, M; Rinaldi, A; Schraml, P; Svinkina, T; Theurillat, JP; Udeshi, ND; Ulbricht, A; Wild, PJ; Winterhoff, BJN1
Chen, Y; Gao, K; He, Y; Huang, H; Li, Y; Lin, D; Liu, X; Lu, D; Pan, CW; Ren, S; Sun, Y; Wang, C; Wang, D; Wang, L; Wang, S; Wang, Y; Wu, D; Yan, Y; Yang, Y; Ye, Z; Yu, L; Zhang, J; Zhang, P; Zhao, S; Zhao, Y; Zhu, Y1
Ciotkowska, A; Gratzke, C; Hennenberg, M; Herlemann, A; Keller, P; Rutz, B; Schott, M; Stief, CG; Strittmatter, F; Tamalunas, A; Waidelich, R; Wang, Y; Yu, Q1
Abida, W; Armenia, J; Arora, VK; Bernstein, BE; Drier, Y; Freedman, ML; Karthaus, WR; Long, HW; Rockowitz, S; Sawyers, CL; Shah, N; Wang, P; Wongvipat, J; Zheng, D1
Dai, X; Wang, Z; Wei, W1
Akunuri, R; Bhargava, SK; Bonam, SR; Kamal, A; Kumar, HMS; Naidu, VGM; Nayak, VL; Reddy, TS; Reddy, VG; Srihari, P1
Chen, H; Chen, Z; Du, Y; Guo, J; Liu, X; Tan, Y; Wang, L; Wang, M; Wang, X; Weng, X1
Eisermann, K; Ma, HM; Masoodi, KZ; Nelson, JB; Nguyen, HM; O'Malley, K; Parikh, RA; Pascal, LE; Ramos Garcia, R; Shevrin, DH; Vessella, RL; Wang, Y; Wang, Z1
Cary, DR; Hori, A; Imamura, S; Iwata, H; Miki, H; Miyamoto, N; Oguro, Y; Tawada, M1
Huxol, E; Mindt, TL; Valverde, IE1
Bradner, JE; Castillo-Martin, M; Cho, H; Cordon-Cardo, C; Herzka, T; Qi, J; Robinson, BD; Trotman, LC; Wilkinson, JE; Zheng, W1
Börno, ST; Franz, A; Hirsch-Kauffmann, M; Hussong, M; Kerick, M; Lehrach, H; Schweiger, MR; Sültmann, H; Timmermann, B; Wunderlich, A1
Eisner, JR; Hoekstra, WJ; Moore, WR; Rafferty, SW; Schotzinger, RJ1
Avanzo, RE; Carabelos, MN; D'Accorso, NB; Fascio, ML; Gueron, G; Schuster, F; Vazquez, E1
Addis, A; Di Cesare, E; Festuccia, C; Gravina, GL; Kauffman, M; Landesman, Y; Lenzi, A; Mancini, A; McCauley, D; Shacham, S; Tortoreto, M; Zaffaroni, N1
Altimari, JM; Henderson, LC; Lohning, AE; Niranjan, B; Risbridger, GP; Schweiker, SS1
Al-Harbi, NO; Amr, Ael-G; Bahashwan, SA; Fayed, AA; Ramadan, MA1
Goodman, OB; Mitra, R1
Albrecht, BK; Bauer, D; Bellon, SF; Boezio, A; Boezio, C; Broome, MA; Choquette, D; Copeland, KW; Dussault, I; Harmange, JC; Lewis, R; Lin, MH; Liu, J; Lohman, J; Peterson, EA; Potashman, M; Rex, K; Shimanovich, R; Teffera, Y; Vaida, KR; Whittington, DA1
Bradner, JE; Chan, SC; Dehm, SM; Li, Y; Miao, L; Nyquist, MD; Raj, GV; Selth, LA; Tilley, WD1
Ahn, JS; Erikson, RL; Goda, AE; Kim, BY1
Bansal, N; Bertino, JR; DiPaola, RS; Mishra, PJ; Stein, M1
Beraldi, E; Cong, M; Gleave, M; Peng, L; Wang, M; Xia, Y; Zoubeidi, A1
Festuccia, C; Gravina, GL; Kauffman, M; Landesman, Y; Mancini, A; Marampon, F; McCauley, D; Sanita, P; Shacham, S; Ventura, L; Vitale, F1
Christopoulos, A; Gregory, KJ; May, LT; Tan, CY; Vecchio, EA; White, PJ1
Altimari, JM; Barbante, GJ; Francis, PS; Gibert, Y; Henderson, LC; Hockey, SC; Yoganantharajah, P1
Abbott, DH; Bird, IM1
Blee, AM; Huang, H; Liu, S; Wang, L1
Chatterjee, S; Chen, Y; Lisok, A; Mease, RC; Pomper, MG; Pullambhatla, M; Sgouros, G; Wang, Y; Wharram, B1
Bala, V; Chaturvedi, S; Gupta, G; Gupta, S; Konwar, R; Maikhuri, JP; Mandalapu, D; Saini, KS; Sharma, V; Sharma, VL; Thakur, S; Wahajuddin, M; Yaseen Malik, M1
Beretta, GL; Cortesi, M; De Cesare, M; Ferroni, C; Guerrini, A; Kim, YS; Lee, S; Malhotra, SV; Parenti, MD; Pepe, A; Tesei, A; Trepel, JB; Varchi, G; Zaffaroni, N; Zamagni, A1
Ahmad, KA; Ahmed, K; Harris, NH; Wang, G1
Götz, C; Hessenauer, A; Montenarh, M; Schneider, CC2
Benny, PD; Bucar, DK; Macgillivray, LR; Moore, AL1
Arseni, B; Campo, S; D'Alessio, V; De Santis, R; Loiarro, M; Rossi, S; Ruggiero, V; Sette, C1
Götz, C; Günther, J; Hessenauer, A; Kartarius, S; Montenarh, M; Schneider, CC1
Banerjee, S; Dhyani, MV; Korde, A; Satpati, D1
Kozłowska, E; Orzechowska, E; Staroń, K; Trzcińska-Danielewicz, J1
Acquaviva, J; Friedland, JC; He, S; Proia, DA; Sang, J; Sequeira, M; Shafi, AA; Smith, DL; Wada, Y; Weigel, NL; Zhang, C1
Bruneteau, G; Clément, O; Cuénod, CA; Frija, G; Frouin, F; Kahn, E; Pradel, C; Siauve, N1
George, D; Kantoff, PW; Kaufman, D; Kazanis, M; Manola, J; Oh, WK; Smith, MR1
Didier, A; Hartel, A; Meyer, HH; Pfaffl, MW1
Chao, YY; Jan, CR1
Brodie, AM; Handratta, VD; Jelovac, D; Kataria, R; Long, BJ; Njar, VC; Nnane, IP1
Battaglia, M; Bertaccini, A; Boccardo, F; Comeri, G; Conti, G; Di Tonno, P; Durand, F; Ferraris, V; Galassi, P; Macchiarella, A; Manganelli, A; Martorana, G; Montefiore, F; Muscas, G; Potenzoni, D; Rubagotti, A; Selvaggi, FP; Siragusa, A; Zattoni, F1
Gallo, J; Morris, T; Saltzstein, D; Sieber, P1
Boccardo, F; Conti, G; Del Monaco, D; Manganelli, A; Potenzoni, D; Rubagotti, A1
Thönnessen, D; Wenz, F1
Fang, RY; He, QJ; Lou, YJ; Yang, B1
Ahmad, KA; Ahmed, K; Wang, G1
Antognelli, C; Baldracchini, F; Brancadoro, C; Cottini, E; Del Buono, C; Mearini, E; Talesa, V; Zucchi, A1
Friedlander, ML; Kohn, EC; Qu, XJ; Yang, JL; Yu, Y1
Blackmore, PF; Kohn, EC; Palad, AJ; Rhim, JS; Schellhammer, PF; Somers, KD; Wasilenko, WJ; Wright, GL1
Brodie, AM; Grigoryev, DN; Kato, K; Long, BJ; Njar, VC; Nnane, IP1
Bauer, KS; Dyer, V; Figg, WD; Hamilton, JM; Jones, EC; Linehan, WM; Pluda, JM; Premkumar, A; Reed, E; Steinberg, SM1
Colciago, A; Motta, M; Negri-Cesi, P; Poletti, A1
Brodie, AA; Njar, VC; Nnane, IP1
Cohen, RB; Fisch, MJ; Myers, CE; Petroni, GR; Santen, RJ; Theodorescu, D1
Tudhope, GR1

Reviews

1 review(s) available for triazoles and Cancer of Prostate

ArticleYear
The hunt for a selective 17,20 lyase inhibitor; learning lessons from nature.
    The Journal of steroid biochemistry and molecular biology, 2016, Volume: 163

    Topics: Adrenal Hyperplasia, Congenital; Androstadienes; Androstenes; Antineoplastic Agents; Benzimidazoles; Cytochrome P-450 CYP3A Inhibitors; Drug Therapy, Combination; Humans; Hydrocortisone; Imidazoles; Ketoconazole; Male; Naphthalenes; Prednisone; Prostate; Prostatic Neoplasms; Protective Factors; Steroid 17-alpha-Hydroxylase; Triazoles

2016

Trials

6 trial(s) available for triazoles and Cancer of Prostate

ArticleYear
Selective aromatase inhibition for patients with androgen-independent prostate carcinoma.
    Cancer, 2002, Nov-01, Volume: 95, Issue:9

    Topics: Aged; Aged, 80 and over; Androgens; Antineoplastic Agents; Aromatase Inhibitors; Enzyme Inhibitors; Estradiol; Humans; Letrozole; Male; Middle Aged; Neoplasms, Hormone-Dependent; Nitriles; Prostate-Specific Antigen; Prostatic Neoplasms; Sex Hormone-Binding Globulin; Testosterone; Triazoles

2002
Evaluation of tamoxifen and anastrozole in the prevention of gynecomastia and breast pain induced by bicalutamide monotherapy of prostate cancer.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Feb-01, Volume: 23, Issue:4

    Topics: Aged; Aged, 80 and over; Anastrozole; Anilides; Breast Diseases; Double-Blind Method; Gynecomastia; Humans; Male; Middle Aged; Nitriles; Pain; Prostate-Specific Antigen; Prostatic Neoplasms; Quality of Life; Tamoxifen; Testosterone; Tosyl Compounds; Triazoles

2005
Prevention and management of bicalutamide-induced gynecomastia and breast pain: randomized endocrinologic and clinical studies with tamoxifen and anastrozole.
    Prostate cancer and prostatic diseases, 2005, Volume: 8, Issue:1

    Topics: Aged; Aged, 80 and over; Anastrozole; Anilides; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Diseases; Double-Blind Method; Gynecomastia; Humans; Male; Middle Aged; Nitriles; Pain; Placebos; Prostatic Neoplasms; Tamoxifen; Testosterone; Tosyl Compounds; Treatment Outcome; Triazoles

2005
Exploratory study of drug plasma levels during bicalutamide 150 mg therapy co-administered with tamoxifen or anastrozole for prophylaxis of gynecomastia and breast pain in men with prostate cancer.
    Cancer chemotherapy and pharmacology, 2005, Volume: 56, Issue:4

    Topics: Aged; Aged, 80 and over; Anastrozole; Androgen Antagonists; Anilides; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Chromatography, High Pressure Liquid; Double-Blind Method; Drug Interactions; Gynecomastia; Humans; Male; Middle Aged; Nitriles; Pain; Prostatic Neoplasms; Tamoxifen; Tosyl Compounds; Triazoles

2005
A pharmacokinetically guided Phase II study of carboxyamido-triazole in androgen-independent prostate cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:9

    Topics: Adenocarcinoma; Aged; Androgens; Angiogenesis Inhibitors; Antineoplastic Agents; Humans; Male; Middle Aged; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Triazoles

1999
Use of the aromatase inhibitor anastrozole in the treatment of patients with advanced prostate carcinoma.
    Cancer, 2001, Oct-15, Volume: 92, Issue:8

    Topics: Aged; Aged, 80 and over; Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Enzyme Inhibitors; Humans; Male; Middle Aged; Nitriles; Pain Measurement; Prostate-Specific Antigen; Prostatic Neoplasms; Triazoles

2001

Other Studies

65 other study(ies) available for triazoles and Cancer of Prostate

ArticleYear
Transcriptional network involving ERG and AR orchestrates Distal-less homeobox-1 mediated prostate cancer progression.
    Nature communications, 2021, 09-07, Volume: 12, Issue:1

    Topics: Androgen Antagonists; Animals; Azepines; Cell Line, Tumor; Disease Progression; Gene Expression Regulation, Neoplastic; Hepatocyte Nuclear Factor 3-alpha; Homeodomain Proteins; Humans; Male; Mice; Mice, Knockout; Mice, SCID; Neoplasm Metastasis; Oncogene Proteins, Fusion; Promoter Regions, Genetic; Prostate; Prostatic Neoplasms; Protein Binding; Receptors, Androgen; Serine Endopeptidases; Signal Transduction; Survival Analysis; Transcription Factors; Transcription, Genetic; Transcriptional Regulator ERG; Triazoles; Xenograft Model Antitumor Assays

2021
Novel indazole skeleton derivatives containing 1,2,3-triazole as potential anti-prostate cancer drugs.
    Bioorganic & medicinal chemistry letters, 2022, 05-15, Volume: 64

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Indazoles; Male; Molecular Structure; Prostatic Neoplasms; Skeleton; Structure-Activity Relationship; Triazoles

2022
Selective Induction of DNA Damage and Cell Cycle Arrest Mediated by Chromone-Triazole Dyads Derivatives: Effects on Breast and Prostate Cancer Cells.
    Chemistry & biodiversity, 2023, Volume: 20, Issue:7

    Topics: Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Chromones; DNA Damage; Drug Screening Assays, Antitumor; G2 Phase Cell Cycle Checkpoints; Humans; Male; Prostate; Prostatic Neoplasms; Structure-Activity Relationship; Triazoles

2023
Small molecule JQ1 promotes prostate cancer invasion via BET-independent inactivation of FOXA1.
    The Journal of clinical investigation, 2020, 04-01, Volume: 130, Issue:4

    Topics: Animals; Azepines; Epithelial-Mesenchymal Transition; Hepatocyte Nuclear Factor 3-alpha; Humans; Male; Mice; Mice, SCID; Neoplasm Invasiveness; Neoplasm Proteins; PC-3 Cells; Prostatic Neoplasms; Proteins; Triazoles; Xenograft Model Antitumor Assays

2020
The combined effect of epigenetic inhibitors for LSD1 and BRD4 alters prostate cancer growth and invasion.
    Aging, 2020, 01-05, Volume: 12, Issue:1

    Topics: Animals; Apoptosis; Azepines; Cell Cycle Proteins; Cell Line, Tumor; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Histone Demethylases; Humans; Male; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Receptors, Androgen; Transcription Factors; Triazoles

2020
Long non-coding RNA MANCR is a target of BET bromodomain protein BRD4 and plays a critical role in cellular migration and invasion abilities of prostate cancer.
    Biochemical and biophysical research communications, 2020, 05-21, Volume: 526, Issue:1

    Topics: Azepines; Cell Cycle Proteins; Cell Line, Tumor; Cell Movement; Down-Regulation; Enhancer Elements, Genetic; Gene Expression Regulation, Neoplastic; Humans; Male; Neoplasm Invasiveness; Prostatic Neoplasms; RNA, Untranslated; Transcription Factors; Triazoles

2020
Protein kinase CK2 impact on intracellular calcium homeostasis in prostate cancer.
    Molecular and cellular biochemistry, 2020, Volume: 470, Issue:1-2

    Topics: Animals; Apoptosis; Calcium; Casein Kinase II; Cell Line, Tumor; Cell Survival; Cytosol; Endoplasmic Reticulum; Homeostasis; Humans; Male; Membrane Potential, Mitochondrial; Mice; Mice, Nude; Naphthyridines; Phenazines; Prostatic Neoplasms; Triazoles

2020
2H-1,2,3-Triazole-chalcones as novel cytotoxic agents against prostate cancer.
    Bioorganic & medicinal chemistry letters, 2020, 10-01, Volume: 30, Issue:19

    Topics: Antineoplastic Agents; Chalcones; Drug Screening Assays, Antitumor; Humans; Male; Molecular Structure; PC-3 Cells; Prostatic Neoplasms; Quantitative Structure-Activity Relationship; Triazoles

2020
Fulvestrant plus LHRH analogues in male with synchronous breast and prostate cancer.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2017, 08-01, Volume: 28, Issue:8

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms, Male; Estradiol; Fulvestrant; Gonadotropin-Releasing Hormone; Humans; Letrozole; Male; Neoplasms, Multiple Primary; Nitriles; Prostatic Neoplasms; Tamoxifen; Triazoles

2017
Targeting AXL overcomes resistance to docetaxel therapy in advanced prostate cancer.
    Oncotarget, 2017, Jun-20, Volume: 8, Issue:25

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Axl Receptor Tyrosine Kinase; Benzocycloheptenes; Cell Line, Tumor; Docetaxel; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Male; Mice, Nude; Piperazines; Prostatic Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Pyrimidines; Receptor Protein-Tyrosine Kinases; RNA Interference; Taxoids; Thiourea; Triazoles; Xenograft Model Antitumor Assays

2017
Biology and evolution of poorly differentiated neuroendocrine tumors.
    Nature medicine, 2017, Jun-06, Volume: 23, Issue:6

    Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Azepines; Benzodiazepines; Carcinogenesis; Carcinoma, Neuroendocrine; Carcinoma, Small Cell; Cell Differentiation; Cell Lineage; Cell Plasticity; Colonic Neoplasms; Disease Progression; Epigenesis, Genetic; Esophageal Neoplasms; Female; Head and Neck Neoplasms; Humans; Lung Neoplasms; Male; Molecular Targeted Therapy; Neoplasms, Glandular and Epithelial; Neuroendocrine Tumors; Ovarian Neoplasms; Prostatic Neoplasms; Proto-Oncogene Proteins c-met; Proto-Oncogene Proteins c-myc; Pyrimidines; Retinoblastoma Binding Proteins; Triazoles; Tumor Suppressor Protein p53; Ubiquitin-Protein Ligases; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms

2017
Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4.
    Nature medicine, 2017, Volume: 23, Issue:9

    Topics: Apoptosis; Azepines; Benzodiazepines; Cell Cycle Proteins; Cell Proliferation; Cullin Proteins; Drug Resistance, Neoplasm; HEK293 Cells; HeLa Cells; Humans; Immunoblotting; Immunoprecipitation; Male; Molecular Targeted Therapy; Nuclear Proteins; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Repressor Proteins; RNA-Binding Proteins; Thalidomide; Transcription Factors; Triazoles; Ubiquitination

2017
Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors.
    Nature medicine, 2017, Volume: 23, Issue:9

    Topics: Acetanilides; Adenocarcinoma, Clear Cell; Animals; Apoptosis; Azepines; Carcinoma, Endometrioid; Carcinosarcoma; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Chromatography, Liquid; Cullin Proteins; Drug Resistance, Neoplasm; Endometrial Neoplasms; Epigenesis, Genetic; Female; Heterocyclic Compounds, 3-Ring; Humans; Immunoblotting; Immunohistochemistry; Immunoprecipitation; Male; Mass Spectrometry; Mice, Nude; Molecular Targeted Therapy; Mutation; Neoplasm Transplantation; Neoplasms, Cystic, Mucinous, and Serous; Nuclear Proteins; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA-Binding Proteins; Transcription Factors; Triazoles; Ubiquitination

2017
Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation.
    Nature medicine, 2017, Volume: 23, Issue:9

    Topics: Azepines; Blotting, Western; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; Gene Expression Profiling; Humans; Immunoprecipitation; Male; Mechanistic Target of Rapamycin Complex 1; Molecular Targeted Therapy; Multiprotein Complexes; Mutation; Nuclear Proteins; Prostatic Neoplasms; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; rac1 GTP-Binding Protein; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA-Binding Proteins; TOR Serine-Threonine Kinases; Transcription Factors; Triazoles

2017
Inhibition of smooth muscle contraction and ARF6 activity by the inhibitor for cytohesin GEFs, secinH3, in the human prostate.
    American journal of physiology. Renal physiology, 2018, 01-01, Volume: 314, Issue:1

    Topics: ADP-Ribosylation Factor 6; ADP-Ribosylation Factors; Humans; Male; Muscle Contraction; Muscle, Smooth; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Prostate; Prostatic Neoplasms; Triazoles

2018
Regulation of the glucocorticoid receptor via a BET-dependent enhancer drives antiandrogen resistance in prostate cancer.
    eLife, 2017, 09-11, Volume: 6

    Topics: Androgen Antagonists; Animals; Azepines; Benzamides; Cell Line, Tumor; Chromatin Immunoprecipitation; Clustered Regularly Interspaced Short Palindromic Repeats; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Heterografts; Humans; Male; Metabolism, Inborn Errors; Mice; Nitriles; Phenylthiohydantoin; Prostatic Neoplasms; Receptors, Androgen; Receptors, Glucocorticoid; Sequence Analysis; Signal Transduction; Triazoles

2017
SPOP-mediated degradation of BRD4 dictates cellular sensitivity to BET inhibitors.
    Cell cycle (Georgetown, Tex.), 2017, Volume: 16, Issue:24

    Topics: Azepines; Cell Cycle Proteins; Cell Proliferation; Cullin Proteins; Humans; Male; Mutagenesis; Nuclear Proteins; Prostatic Neoplasms; Proteins; Repressor Proteins; RNA Interference; RNA, Small Interfering; Signal Transduction; Transcription Factors; Triazoles

2017
4β-amidotriazole linked podophyllotoxin congeners: DNA topoisomerase-IIα inhibition and potential anticancer agents for prostate cancer.
    European journal of medicinal chemistry, 2018, Jan-20, Volume: 144

    Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Proliferation; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Humans; Male; Membrane Potential, Mitochondrial; Molecular Docking Simulation; Molecular Structure; Podophyllotoxin; Prostatic Neoplasms; Reactive Oxygen Species; Structure-Activity Relationship; Topoisomerase II Inhibitors; Triazoles; Tumor Cells, Cultured

2018
Inhibition of BRD4 suppresses tumor growth in prostate cancer via the enhancement of FOXO1 expression.
    International journal of oncology, 2018, Volume: 53, Issue:6

    Topics: Aged; Aged, 80 and over; Animals; Azepines; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; Forkhead Box Protein O1; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Neoplasm Transplantation; Nuclear Proteins; Prostatic Neoplasms; Proto-Oncogene Proteins c-myc; RNA, Small Interfering; Transcription Factors; Triazoles; Up-Regulation

2018
5α-reductase inhibition suppresses testosterone-induced initial regrowth of regressed xenograft prostate tumors in animal models.
    Endocrinology, 2013, Volume: 154, Issue:7

    Topics: 5-alpha Reductase Inhibitors; Animals; Azasteroids; Cell Line, Tumor; Cell Proliferation; Dutasteride; Finasteride; Humans; Immunohistochemistry; Letrozole; Male; Mice; Mice, Nude; Mice, SCID; Nitriles; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; Testosterone; Triazoles

2013
Design, synthesis, and evaluation of novel VEGFR2 kinase inhibitors: discovery of [1,2,4]triazolo[1,5-a]pyridine derivatives with slow dissociation kinetics.
    Bioorganic & medicinal chemistry, 2013, Aug-01, Volume: 21, Issue:15

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Design; Human Umbilical Vein Endothelial Cells; Humans; Kinetics; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Structure; Prostatic Neoplasms; Protein Kinase Inhibitors; Pyridines; Random Allocation; Structure-Activity Relationship; Triazoles; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays

2013
Radiolabeled antagonistic bombesin peptidomimetics for tumor targeting.
    Journal of labelled compounds & radiopharmaceuticals, 2014, Volume: 57, Issue:4

    Topics: Amino Acid Sequence; Bombesin; Cell Line, Tumor; Heterocyclic Compounds, 1-Ring; Humans; Isotope Labeling; Lutetium; Male; Peptide Fragments; Peptidomimetics; Prostatic Neoplasms; Proteolysis; Radioisotopes; Tomography, Emission-Computed, Single-Photon; Triazoles

2014
RapidCaP, a novel GEM model for metastatic prostate cancer analysis and therapy, reveals myc as a driver of Pten-mutant metastasis.
    Cancer discovery, 2014, Volume: 4, Issue:3

    Topics: Animals; Azepines; Gene Expression Regulation, Neoplastic; Genetic Vectors; HEK293 Cells; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neoplasm Metastasis; Neoplasms, Experimental; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; PTEN Phosphohydrolase; Retroviridae; Triazoles; Tumor Suppressor Protein p53

2014
The bromodomain protein BRD4 regulates the KEAP1/NRF2-dependent oxidative stress response.
    Cell death & disease, 2014, Apr-24, Volume: 5

    Topics: Azepines; Base Sequence; Binding Sites; Cell Cycle Proteins; Cell Survival; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Heme Oxygenase-1; Humans; Intracellular Signaling Peptides and Proteins; Kelch-Like ECH-Associated Protein 1; Male; Models, Biological; Molecular Sequence Data; NF-E2-Related Factor 2; Nuclear Proteins; Nucleotide Motifs; Oxidative Stress; Prostatic Neoplasms; Protein Binding; Protoporphyrins; Reactive Oxygen Species; Sp1 Transcription Factor; Transcription Factors; Transcription, Genetic; Triazoles

2014
Highly-selective 4-(1,2,3-triazole)-based P450c17a 17,20-lyase inhibitors.
    Bioorganic & medicinal chemistry letters, 2014, Jun-01, Volume: 24, Issue:11

    Topics: Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Male; Molecular Structure; Prostatic Neoplasms; Rats; Steroid 17-alpha-Hydroxylase; Structure-Activity Relationship; Triazoles

2014
Differential effect of heterocyclic D-ribofuranoside derivatives on human prostate cancer cell viability and cell cycle progression.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2014, Volume: 68, Issue:7

    Topics: Alkenes; Antineoplastic Agents; Carbohydrates; Cell Line, Tumor; Cell Survival; G1 Phase Cell Cycle Checkpoints; Humans; Isoxazoles; Male; Prostatic Neoplasms; Resting Phase, Cell Cycle; Triazoles

2014
XPO1/CRM1-selective inhibitors of nuclear export (SINE) reduce tumor spreading and improve overall survival in preclinical models of prostate cancer (PCa).
    Journal of hematology & oncology, 2014, Oct-05, Volume: 7

    Topics: Active Transport, Cell Nucleus; Animals; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Movement; Exportin 1 Protein; Humans; Hydrazines; Karyopherins; Male; Mice, SCID; Neoplasm Metastasis; Osteoblasts; Prostatic Neoplasms; Receptors, Cytoplasmic and Nuclear; Triazoles; Xenograft Model Antitumor Assays

2014
Synthesis and preliminary investigations into novel 1,2,3-triazole-derived androgen receptor antagonists inspired by bicalutamide.
    Bioorganic & medicinal chemistry letters, 2014, Nov-01, Volume: 24, Issue:21

    Topics: Androgen Antagonists; Androgen Receptor Antagonists; Anilides; Cell Survival; Humans; Male; Nitriles; Prostatic Neoplasms; Receptors, Androgen; Tosyl Compounds; Triazoles; Tumor Cells, Cultured

2014
Androgen receptor antagonists and anti-prostate cancer activities of some newly synthesized substituted fused pyrazolo-, triazolo- and thiazolo-pyrimidine derivatives.
    International journal of molecular sciences, 2014, Nov-24, Volume: 15, Issue:11

    Topics: Androgen Receptor Antagonists; Animals; Antineoplastic Agents; Cell Line; Cell Line, Tumor; CHO Cells; Cricetulus; Humans; Lethal Dose 50; Male; Prostatic Neoplasms; Pyrazoles; Pyrimidines; Thiazoles; Triazoles

2014
CYP3A5 regulates prostate cancer cell growth by facilitating nuclear translocation of AR.
    The Prostate, 2015, Apr-01, Volume: 75, Issue:5

    Topics: Blotting, Western; Bridged-Ring Compounds; Cell Line, Tumor; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dihydrotestosterone; Fluorescent Antibody Technique; Humans; Male; Metribolone; Prostatic Neoplasms; Real-Time Polymerase Chain Reaction; Receptors, Androgen; RNA, Small Interfering; Signal Transduction; Triazoles

2015
Discovery of potent and selective 8-fluorotriazolopyridine c-Met inhibitors.
    Journal of medicinal chemistry, 2015, Mar-12, Volume: 58, Issue:5

    Topics: Animals; Cell Proliferation; Drug Design; Drug Discovery; Hepatocyte Growth Factor; Humans; Male; Mice; Microsomes, Liver; Models, Molecular; Molecular Structure; Phosphorylation; Prostatic Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Quinolines; Rats; Rats, Sprague-Dawley; Signal Transduction; Tissue Distribution; Triazoles; Xenograft Model Antitumor Assays

2015
Targeting chromatin binding regulation of constitutively active AR variants to overcome prostate cancer resistance to endocrine-based therapies.
    Nucleic acids research, 2015, Jul-13, Volume: 43, Issue:12

    Topics: Animals; Antineoplastic Agents; Azepines; Benzamides; Cell Line; Cell Line, Tumor; Chromatin; Dimerization; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Male; Mice, Nude; Nitriles; Phenylthiohydantoin; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Receptors, Androgen; Response Elements; Transcriptional Activation; Triazoles

2015
Induction of G1 Arrest by SB265610 Involves Cyclin D3 Down-regulation and Suppression of CDK2 (Thr160) Phosphorylation.
    Anticancer research, 2015, Volume: 35, Issue:6

    Topics: Cell Cycle Checkpoints; Cyclin D3; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; G1 Phase; Gene Expression Regulation, Neoplastic; Humans; Interleukin-8; Male; p38 Mitogen-Activated Protein Kinases; Phenylurea Compounds; Phosphorylation; Prostatic Neoplasms; Receptors, Interleukin-8B; Triazoles; Tumor Microenvironment

2015
Axl receptor tyrosine kinase is up-regulated in metformin resistant prostate cancer cells.
    Oncotarget, 2015, Jun-20, Volume: 6, Issue:17

    Topics: Adenylate Kinase; Antineoplastic Agents; Axl Receptor Tyrosine Kinase; Benzocycloheptenes; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclin D1; Docetaxel; Drug Resistance, Neoplasm; Enzyme Activation; Epithelial-Mesenchymal Transition; Gene Knockdown Techniques; Humans; Male; Metformin; Neoplasm Invasiveness; Prostatic Neoplasms; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor Protein-Tyrosine Kinases; Taxoids; Triazoles; Up-Regulation

2015
A Novel Triazole Nucleoside Suppresses Prostate Cancer Cell Growth by Inhibiting Heat Shock Factor 1 and Androgen Receptor.
    Anti-cancer agents in medicinal chemistry, 2015, Volume: 15, Issue:10

    Topics: Cell Line, Tumor; Heat-Shock Proteins; Humans; Male; Prostatic Neoplasms; Receptors, Androgen; Triazoles

2015
KPT-330, a potent and selective exportin-1 (XPO-1) inhibitor, shows antitumor effects modulating the expression of cyclin D1 and survivin [corrected] in prostate cancer models.
    BMC cancer, 2015, Dec-01, Volume: 15

    Topics: Adult; Analgesics; Animals; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin D1; Gene Expression Regulation, Neoplastic; Humans; Hydrazines; Inhibitor of Apoptosis Proteins; Male; Mice; Mice, Nude; Neoplasm Grading; Oxadiazoles; Prostatic Neoplasms; Survivin; Triazoles; Up-Regulation; Xenograft Model Antitumor Assays

2015
Ligand-Independent Adenosine A2B Receptor Constitutive Activity as a Promoter of Prostate Cancer Cell Proliferation.
    The Journal of pharmacology and experimental therapeutics, 2016, Volume: 357, Issue:1

    Topics: Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine Deaminase; Animals; Cell Line, Tumor; Cell Proliferation; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Drug Design; Humans; Inositol Phosphates; Ligands; Male; MAP Kinase Signaling System; Prostatic Neoplasms; Receptor, Adenosine A2B; Signal Transduction; Sulfonamides; Triazines; Triazoles; Xanthines

2016
A comparison of novel organoiridium(III) complexes and their ligands as a potential treatment for prostate cancer.
    European journal of medicinal chemistry, 2016, Feb-15, Volume: 109

    Topics: Animals; Antineoplastic Agents; Apoptosis; Caspase 3; Cell Line, Tumor; Click Chemistry; Coordination Complexes; Humans; Iridium; Ligands; Male; Prostate; Prostatic Neoplasms; Triazoles; Zebrafish

2016
BET bromodomain-mediated interaction between ERG and BRD4 promotes prostate cancer cell invasion.
    Oncotarget, 2016, Jun-21, Volume: 7, Issue:25

    Topics: Azepines; Base Sequence; Benzodiazepines; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; HEK293 Cells; Humans; Male; Neoplasm Invasiveness; Nuclear Proteins; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Proteins; Transcription Factors; Transcriptional Regulator ERG; Triazoles

2016
[(18)F]Fluoroethyl Triazole Substituted PSMA Inhibitor Exhibiting Rapid Normal Organ Clearance.
    Bioconjugate chemistry, 2016, 07-20, Volume: 27, Issue:7

    Topics: Animals; Antigens, Surface; Cell Line, Tumor; Click Chemistry; Enzyme Inhibitors; Glutamate Carboxypeptidase II; Humans; Male; Mice; Positron-Emission Tomography; Prostatic Neoplasms; Structure-Activity Relationship; Tissue Distribution; Triazoles

2016
Synthesis and biological evaluation of some novel triazole hybrids of curcumin mimics and their selective anticancer activity against breast and prostate cancer cell lines.
    Bioorganic & medicinal chemistry letters, 2016, 09-01, Volume: 26, Issue:17

    Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Click Chemistry; Curcumin; Down-Regulation; Drug Screening Assays, Antitumor; Female; Half-Life; HEK293 Cells; Humans; Male; Membrane Potential, Mitochondrial; Proliferating Cell Nuclear Antigen; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Triazoles

2016
1,4-Substituted Triazoles as Nonsteroidal Anti-Androgens for Prostate Cancer Treatment.
    Journal of medicinal chemistry, 2017, 04-13, Volume: 60, Issue:7

    Topics: Animals; Cell Line, Tumor; Drug Discovery; Gene Expression Regulation, Neoplastic; Humans; Male; Mice, Nude; Models, Molecular; Nonsteroidal Anti-Androgens; Prostate; Prostate-Specific Antigen; Prostatic Neoplasms; RNA, Messenger; Triazoles

2017
Impact of protein kinase CK2 on inhibitor of apoptosis proteins in prostate cancer cells.
    Molecular and cellular biochemistry, 2008, Volume: 316, Issue:1-2

    Topics: Apigenin; Apoptosis; Apoptosis Regulatory Proteins; Casein Kinase II; Caspases; Cell Line, Tumor; Humans; Male; Prostatic Neoplasms; Protein Kinase Inhibitors; Subcellular Fractions; Triazoles

2008
DMAT, an inhibitor of protein kinase CK2 induces reactive oxygen species and DNA double strand breaks.
    Oncology reports, 2009, Volume: 21, Issue:6

    Topics: Antineoplastic Agents; Apoptosis; Benzimidazoles; Casein Kinase II; Cell Line, Tumor; Cell Survival; DNA Breaks, Double-Stranded; Humans; Male; Oxidative Stress; Prostatic Neoplasms; Protein Kinase Inhibitors; Reactive Oxygen Species; Time Factors; Triazoles; Up-Regulation

2009
p53 is dispensable for the induction of apoptosis after inhibition of protein kinase CK2.
    The Prostate, 2010, Feb-01, Volume: 70, Issue:2

    Topics: Apoptosis; Casein Kinase II; Cell Line, Tumor; Cell Proliferation; Cell Survival; Enzyme Inhibitors; Humans; Male; Prostatic Neoplasms; Triazoles; Tumor Suppressor Protein p53

2010
"Click" labeling strategy for M(CO)(3) (M = Re, (99m)Tc) prostate cancer targeted flutamide agents.
    Dalton transactions (Cambridge, England : 2003), 2010, Feb-28, Volume: 39, Issue:8

    Topics: Crystallography, X-Ray; Flutamide; Humans; Isotope Labeling; Male; Molecular Conformation; Prostatic Neoplasms; Radionuclide Imaging; Radiopharmaceuticals; Receptors, Androgen; Rhenium; Technetium; Triazoles

2010
Anti-proliferative effect of a triazole derivative (ST1959) on LNCaP human prostate cancer cells through down-regulation of cyclin and androgen receptor expression.
    The Prostate, 2011, Jan-01, Volume: 71, Issue:1

    Topics: Adenocarcinoma; Cell Line, Tumor; Cell Proliferation; Cyclins; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Immunosuppressive Agents; Male; Prostatic Neoplasms; Receptors, Androgen; Triazoles

2011
Down-regulation of CK2 activity results in a decrease in the level of cdc25C phosphatase in different prostate cancer cell lines.
    Molecular and cellular biochemistry, 2011, Volume: 356, Issue:1-2

    Topics: Anthraquinones; Apoptosis; Benzimidazoles; Casein Kinase II; CDC2 Protein Kinase; cdc25 Phosphatases; Cell Line, Tumor; Down-Regulation; Genes, Dominant; Humans; Male; Mutant Proteins; Prostatic Neoplasms; Protein Kinase Inhibitors; Transfection; Triazoles

2011
Synthesis and preliminary bioevaluation of 99mTc(CO)3-17α-triazolylandrost-4-ene-3-one derivative prepared via click chemistry route.
    Cancer biotherapy & radiopharmaceuticals, 2011, Volume: 26, Issue:5

    Topics: Androsterone; Animals; Cell Line, Tumor; Click Chemistry; Humans; Male; Organotechnetium Compounds; Prostatic Neoplasms; Radionuclide Imaging; Rats; Rats, Wistar; Rhenium; Tissue Distribution; Triazoles

2011
Time schedule-dependent effect of the CK2 inhibitor TBB on PC-3 human prostate cancer cell viability.
    Oncology reports, 2012, Volume: 27, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Camptothecin; Cell Line, Tumor; Cell Survival; Checkpoint Kinase 2; Enzyme Inhibitors; Humans; Male; Prostatic Neoplasms; Protein Serine-Threonine Kinases; TNF-Related Apoptosis-Inducing Ligand; Triazoles

2012
Potent activity of the Hsp90 inhibitor ganetespib in prostate cancer cells irrespective of androgen receptor status or variant receptor expression.
    International journal of oncology, 2013, Volume: 42, Issue:1

    Topics: Animals; Apoptosis; Benzoquinones; Blotting, Western; Cell Cycle; Cell Cycle Proteins; Cell Proliferation; Flow Cytometry; HSP90 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Male; Mice; Mice, SCID; Prostatic Neoplasms; Real-Time Polymerase Chain Reaction; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Triazoles; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2013
Assessing perfusion and capillary permeability changes induced by a VEGF inhibitor in human tumor xenografts using macromolecular MR imaging contrast media.
    Academic radiology, 2002, Volume: 9 Suppl 2

    Topics: Animals; Capillary Permeability; Contrast Media; Endothelial Growth Factors; Gadolinium; Heterocyclic Compounds; Intercellular Signaling Peptides and Proteins; Lymphokines; Macromolecular Substances; Magnetic Resonance Imaging; Male; Mice; Mice, Nude; Microcirculation; Neoplasm Transplantation; Neovascularization, Pathologic; Organometallic Compounds; Perfusion; Prostatic Neoplasms; Quinazolines; Transplantation, Heterologous; Triazoles; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2002
Characterisation of gene expression patterns in 22RV1 cells for determination of environmental androgenic/antiandrogenic compounds.
    The Journal of steroid biochemistry and molecular biology, 2003, Volume: 84, Issue:2-3

    Topics: Androgen Antagonists; Androgens; Cell Division; Dioxolanes; Down-Regulation; Environmental Exposure; Estrogen Receptor alpha; Estrogen Receptor beta; Fungicides, Industrial; Gene Expression; Humans; Insecticides; Male; Organotin Compounds; Pesticides; Progestins; Prostatic Neoplasms; Pyrethrins; Receptors, Androgen; Receptors, Estrogen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Teratogens; Time Factors; Transcription, Genetic; Triazoles; Tumor Cells, Cultured; Up-Regulation

2003
Novel effect of Y-24180, a presumed specific platelet activation factor receptor antagonist, on Ca2+ levels and growth of human prostate cancer cells.
    Cellular signalling, 2004, Volume: 16, Issue:8

    Topics: Adenosine Triphosphate; Azepines; Calcium; Calcium Signaling; Cell Proliferation; Dihydropyridines; Diltiazem; Enzyme Inhibitors; Fura-2; Humans; Male; Phorbol Esters; Platelet Membrane Glycoproteins; Prostatic Neoplasms; Protein Kinase C; Receptors, G-Protein-Coupled; Signal Transduction; Thapsigargin; Triazoles; Tumor Cells, Cultured; Verapamil

2004
Potent CYP17 inhibitors: improved syntheses, pharmacokinetics and anti-tumor activity in the LNCaP human prostate cancer model.
    The Journal of steroid biochemistry and molecular biology, 2004, Volume: 92, Issue:3

    Topics: Androstadienes; Androstanols; Animals; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Finasteride; Humans; Imidazoles; Male; Mice; Mice, SCID; Prostatic Neoplasms; Steroid 17-alpha-Hydroxylase; Time Factors; Transplantation, Heterologous; Triazoles

2004
Radiotherapeutic prophylaxis of gynecomastia.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Aug-20, Volume: 23, Issue:24

    Topics: Anastrozole; Androgen Antagonists; Anilides; Antineoplastic Agents, Hormonal; Gynecomastia; Humans; Male; Nitriles; Pain; Prostatic Neoplasms; Quality of Life; Tamoxifen; Tosyl Compounds; Triazoles

2005
Contragestazol (DL111-IT) inhibits proliferation of human androgen-independent prostate cancer cell line PC3 in vitro and in vivo.
    Asian journal of andrology, 2005, Volume: 7, Issue:4

    Topics: Androgens; Animals; Cell Division; Cell Line, Tumor; Cyclin D1; Cyclin-Dependent Kinase 4; Dose-Response Relationship, Drug; Female; G1 Phase; Humans; Immunosuppressive Agents; In Vitro Techniques; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Prostatic Neoplasms; Resting Phase, Cell Cycle; Retinoblastoma Protein; Transplantation, Heterologous; Triazoles

2005
Role of protein kinase CK2 in the regulation of tumor necrosis factor-related apoptosis inducing ligand-induced apoptosis in prostate cancer cells.
    Cancer research, 2006, Feb-15, Volume: 66, Issue:4

    Topics: Androgens; Apoptosis; Apoptosis Regulatory Proteins; bcl-X Protein; Casein Kinase II; Cell Line, Tumor; Drug Synergism; Humans; Lamin Type A; Male; Membrane Glycoproteins; Mitochondria; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; TNF-Related Apoptosis-Inducing Ligand; Transfection; Triazoles; Tumor Necrosis Factor-alpha

2006
Alteration of glyoxalase genes expression in response to testosterone in LNCaP and PC3 human prostate cancer cells.
    Cancer biology & therapy, 2007, Volume: 6, Issue:12

    Topics: Adenocarcinoma; Androgens; Aromatase Inhibitors; Base Sequence; Cell Line, Tumor; Enzyme Induction; Estradiol; Gene Expression Regulation, Neoplastic; Humans; Lactoylglutathione Lyase; Letrozole; Male; Molecular Sequence Data; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Nitriles; Prostatic Neoplasms; Pyruvaldehyde; Response Elements; RNA, Messenger; RNA, Neoplasm; Testosterone; Thiolester Hydrolases; Triazoles

2007
Selective sensitivity to carboxyamidotriazole by human tumor cell lines with DNA mismatch repair deficiency.
    International journal of cancer, 2008, Jul-15, Volume: 123, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; Calcium Channel Blockers; Cell Cycle; Cell Line, Tumor; Chromosomes, Human; Colonic Neoplasms; Colorimetry; DNA Mismatch Repair; Drug Screening Assays, Antitumor; Female; Fluorouracil; Humans; Male; Neoplasm Invasiveness; Neoplasms; Nifedipine; Ovarian Neoplasms; Prostatic Neoplasms; Transfection; Triazoles; Urinary Bladder Neoplasms

2008
Effects of the calcium influx inhibitor carboxyamido-triazole on the proliferation and invasiveness of human prostate tumor cell lines.
    International journal of cancer, 1996, Oct-09, Volume: 68, Issue:2

    Topics: Antineoplastic Agents; Calcium; Cell Division; Humans; Male; Neoplasm Invasiveness; Prostate-Specific Antigen; Prostatic Neoplasms; Triazoles; Tumor Cells, Cultured; Tumor Stem Cell Assay

1996
Novel 17-azolyl steroids, potent inhibitors of human cytochrome 17 alpha-hydroxylase-C17,20-lyase (P450(17) alpha): potential agents for the treatment of prostate cancer.
    Journal of medicinal chemistry, 1998, Mar-12, Volume: 41, Issue:6

    Topics: 5-alpha Reductase Inhibitors; Androgen Antagonists; Androstadienes; Animals; Antineoplastic Agents; Enzyme Inhibitors; Humans; Imidazoles; Ketoconazole; Male; Microsomes; Prostatic Neoplasms; Rats; Rats, Sprague-Dawley; Steroid 17-alpha-Hydroxylase; Structure-Activity Relationship; Testis; Triazoles; Tumor Cells, Cultured

1998
5alpha-reductase isozymes and aromatase are differentially expressed and active in the androgen-independent human prostate cancer cell lines DU145 and PC3.
    The Prostate, 1999, Dec-01, Volume: 41, Issue:4

    Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Anastrozole; Androgens; Androstenedione; Aromatase; Aromatase Inhibitors; Blotting, Southern; Dihydrotestosterone; Enzyme Inhibitors; Etiocholanolone; Humans; Hydrogen-Ion Concentration; Isoenzymes; Male; Microsomes; Nitriles; Prostatic Hyperplasia; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Testosterone; Triazoles; Tumor Cells, Cultured

1999
Pharmacokinetic profile of 3beta-hydroxy-17-(1H-1,2,3-triazol-1-yl)androsta-5,16-diene (VN/87-1), a potent androgen synthesis inhibitor, in mice.
    The Journal of steroid biochemistry and molecular biology, 2001, Volume: 78, Issue:3

    Topics: Androgen Antagonists; Androstanols; Animals; Biological Availability; Humans; Male; Mice; Mice, Inbred BALB C; Mice, SCID; Neoplasm Transplantation; Prostatic Neoplasms; Steroid 17-alpha-Hydroxylase; Transplantation, Heterologous; Triazoles; Tumor Cells, Cultured

2001
The inhibition of catalase by plasma and by human tissue extracts.
    Clinica chimica acta; international journal of clinical chemistry, 1969, Volume: 25, Issue:3

    Topics: Ascorbic Acid; Blood; Carcinoma; Catalase; Conductometry; Dialysis; Edetic Acid; Erythrocytes; Ethylmaleimide; Hemolysis; Hot Temperature; Humans; Kidney; Liver; Lung Neoplasms; Male; Neoplasms; Prostatic Neoplasms; Stomach Neoplasms; Tissue Extracts; Triazoles

1969