KU 2285: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
ID Source | ID |
---|---|
PubMed CID | 366729 |
SCHEMBL ID | 9716538 |
MeSH ID | M0189167 |
Synonym |
---|
nsc-635446 |
nsc635446 |
1h-imidazole-1-propanamide, alpha,alpha-difluoro-n-(2-hydroxyethyl)-2-nitro- |
alpha,alpha-difluoro-n-(2-hydroxyethyl)-2-nitro-1h-imidazole-1-propionamide |
ku-2285 |
ku 2285 |
1h-imidazole-1-propionamide, alpha,alpha-difluoro-n-(2-hydroxyethyl)-2-nitro- |
2,2-difluoro-n-(2-hydroxyethyl)-3-(2-nitro-1h-imidazol-1-yl)propanamide |
121077-11-0 |
2,2-difluoro-n-(2-hydroxyethyl)-3-(2-nitroimidazol-1-yl)propanamide |
doc00vd5vl , |
unii-doc00vd5vl |
1h-imidazole-1-propanamide, .alpha.,.alpha.-difluoro-n-(2-hydroxyethyl)-2-nitro- |
SCHEMBL9716538 |
nsc 635446 |
voxufopzgrtsjy-uhfffaoysa-n |
Q27276509 |
imidazole,2-nitro-1-(3-hydroxyethylamino-3-oxo-2 |
DTXSID40879131 |
AKOS040752286 |
Excerpt | Reference | Relevance |
---|---|---|
"01) less toxic than RK-28 at this dose, as reflected in a lower increase in the brain glucose level (0." | ( Metabolic studies and neurotoxicity in tumors and brain of mice after hypoxic cell sensitizers. Streffer, C; Tamulevicius, P, 1994) | 0.29 |
Excerpt | Reference | Relevance |
---|---|---|
" The pharmacokinetic studies were performed in C3H/He mice bearing the SCCVII tumor." | ( Fluorinated 2-nitroimidazole derivative hypoxic cell radiosensitizers: radiosensitizing activities and pharmacokinetics. Abe, M; Iwai, H; Nishimoto, S; Oya, N; Sasai, K; Shibamoto, Y; Shibata, T; Yoshizawa, T, 1994) | 0.29 |
" Evaluation of pharmacokinetics in the peripheral nerves showed that the apparent biological half-life of SR-2508 increased with the increases in the number of administrations, whereas that of KU-2285 became shorter." | ( Radiosensitizing activity and pharmacokinetics of multiple dose administered KU-2285 in peripheral nerve tissue in mice. Abe, M; Iwai, H; Matsuno, E; Sasai, K; Shibamoto, Y, 1994) | 0.29 |
Excerpt | Reference | Relevance |
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"Since most clinical radiotherapy is given as multiple small irradiation fractions, the present study was undertaken to test the in vivo radiosensitizing activity of a new hypoxic cell radiosensitizer, KU-2285, in combination with radiation dose fractionation." | ( In vivo radiosensitizing activity of a new fluorinated hypoxic cell radiosensitizer, KU-2285, in combination with radiation dose fractionation. Abe, M; Fushiki, M; Iwai, H; Nishimoto, S; Sasai, K; Shibamoto, Y; Suyama, S; Takahashi, M; Yukawa, Y, 1991) | 0.28 |
" In the present study, the in vivo effects of a promising hypoxic cytotoxin, tirapazamine (3-amino-1,2,4-benzotriazine 1,4-di-N-oxide), were examined in comparison with those of KU-2285, one of the best hypoxic cell radiosensitizers, in combination with both single and fractionated irradiation." | ( Comparison of in vivo efficacy of hypoxic cytotoxin tirapazamine and hypoxic cell radiosensitizer KU-2285 in combination with single and fractionated irradiation. Abe, M; Hiraoka, M; Murata, R; Oya, N; Sasai, K; Shibamoto, Y; Shibata, T; Takagi, T, 1996) | 0.29 |
Excerpt | Relevance | Reference |
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" In the present study, the in vivo radiosensitizing activity of KU-2285 in combination with radiation dose fractionation, and the pharmacokinetics of cumulative dosing of KU-2285 in the peripheral nerves were examined." | ( Radiosensitizing activity and pharmacokinetics of multiple dose administered KU-2285 in peripheral nerve tissue in mice. Abe, M; Iwai, H; Matsuno, E; Sasai, K; Shibamoto, Y, 1994) | 0.29 |
" The radiation dose-response curves of MN frequency suggested that the interaction of tirapazamine with irradiation appeared to be essentially additive in both cell lines." | ( Tirapazamine: hypoxic cytotoxicity and interaction with radiation as assessed by the micronucleus assay. Abe, M; Hiraoka, M; Murata, R; Oya, N; Sasai, K; Shibamoto, Y; Shibata, T; Takagi, T; Takahashi, M, 1996) | 0.29 |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 17 (89.47) | 18.2507 |
2000's | 2 (10.53) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 2 (10.53%) | 5.53% |
Reviews | 1 (5.26%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 16 (84.21%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |