Page last updated: 2024-12-08

ku 2285

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

KU 2285: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID366729
SCHEMBL ID9716538
MeSH IDM0189167

Synonyms (20)

Synonym
nsc-635446
nsc635446
1h-imidazole-1-propanamide, alpha,alpha-difluoro-n-(2-hydroxyethyl)-2-nitro-
alpha,alpha-difluoro-n-(2-hydroxyethyl)-2-nitro-1h-imidazole-1-propionamide
ku-2285
ku 2285
1h-imidazole-1-propionamide, alpha,alpha-difluoro-n-(2-hydroxyethyl)-2-nitro-
2,2-difluoro-n-(2-hydroxyethyl)-3-(2-nitro-1h-imidazol-1-yl)propanamide
121077-11-0
2,2-difluoro-n-(2-hydroxyethyl)-3-(2-nitroimidazol-1-yl)propanamide
doc00vd5vl ,
unii-doc00vd5vl
1h-imidazole-1-propanamide, .alpha.,.alpha.-difluoro-n-(2-hydroxyethyl)-2-nitro-
SCHEMBL9716538
nsc 635446
voxufopzgrtsjy-uhfffaoysa-n
Q27276509
imidazole,2-nitro-1-(3-hydroxyethylamino-3-oxo-2
DTXSID40879131
AKOS040752286

Research Excerpts

Toxicity

ExcerptReferenceRelevance
"01) less toxic than RK-28 at this dose, as reflected in a lower increase in the brain glucose level (0."( Metabolic studies and neurotoxicity in tumors and brain of mice after hypoxic cell sensitizers.
Streffer, C; Tamulevicius, P, 1994
)
0.29

Pharmacokinetics

ExcerptReferenceRelevance
" The pharmacokinetic studies were performed in C3H/He mice bearing the SCCVII tumor."( Fluorinated 2-nitroimidazole derivative hypoxic cell radiosensitizers: radiosensitizing activities and pharmacokinetics.
Abe, M; Iwai, H; Nishimoto, S; Oya, N; Sasai, K; Shibamoto, Y; Shibata, T; Yoshizawa, T, 1994
)
0.29
" Evaluation of pharmacokinetics in the peripheral nerves showed that the apparent biological half-life of SR-2508 increased with the increases in the number of administrations, whereas that of KU-2285 became shorter."( Radiosensitizing activity and pharmacokinetics of multiple dose administered KU-2285 in peripheral nerve tissue in mice.
Abe, M; Iwai, H; Matsuno, E; Sasai, K; Shibamoto, Y, 1994
)
0.29

Compound-Compound Interactions

ExcerptReferenceRelevance
"Since most clinical radiotherapy is given as multiple small irradiation fractions, the present study was undertaken to test the in vivo radiosensitizing activity of a new hypoxic cell radiosensitizer, KU-2285, in combination with radiation dose fractionation."( In vivo radiosensitizing activity of a new fluorinated hypoxic cell radiosensitizer, KU-2285, in combination with radiation dose fractionation.
Abe, M; Fushiki, M; Iwai, H; Nishimoto, S; Sasai, K; Shibamoto, Y; Suyama, S; Takahashi, M; Yukawa, Y, 1991
)
0.28
" In the present study, the in vivo effects of a promising hypoxic cytotoxin, tirapazamine (3-amino-1,2,4-benzotriazine 1,4-di-N-oxide), were examined in comparison with those of KU-2285, one of the best hypoxic cell radiosensitizers, in combination with both single and fractionated irradiation."( Comparison of in vivo efficacy of hypoxic cytotoxin tirapazamine and hypoxic cell radiosensitizer KU-2285 in combination with single and fractionated irradiation.
Abe, M; Hiraoka, M; Murata, R; Oya, N; Sasai, K; Shibamoto, Y; Shibata, T; Takagi, T, 1996
)
0.29

Dosage Studied

ExcerptRelevanceReference
" In the present study, the in vivo radiosensitizing activity of KU-2285 in combination with radiation dose fractionation, and the pharmacokinetics of cumulative dosing of KU-2285 in the peripheral nerves were examined."( Radiosensitizing activity and pharmacokinetics of multiple dose administered KU-2285 in peripheral nerve tissue in mice.
Abe, M; Iwai, H; Matsuno, E; Sasai, K; Shibamoto, Y, 1994
)
0.29
" The radiation dose-response curves of MN frequency suggested that the interaction of tirapazamine with irradiation appeared to be essentially additive in both cell lines."( Tirapazamine: hypoxic cytotoxicity and interaction with radiation as assessed by the micronucleus assay.
Abe, M; Hiraoka, M; Murata, R; Oya, N; Sasai, K; Shibamoto, Y; Shibata, T; Takagi, T; Takahashi, M, 1996
)
0.29
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (19)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's17 (89.47)18.2507
2000's2 (10.53)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials2 (10.53%)5.53%
Reviews1 (5.26%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other16 (84.21%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]