Compounds > targocil
Page last updated: 2024-11-13

targocil

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

targocil: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID44547009
CHEMBL ID1086854
SCHEMBL ID10123319
MeSH IDM0560716

Synonyms (18)

Synonym
CHEMBL1086854
3-(4-chlorophenylsulfonyl)-n,n-diethyl-7,8-dimethoxy-[1,2,3]triazolo[1,5-a]quinazolin-5-amine
1200443-21-5
SCHEMBL10123319
3-(4-chlorobenzene-1-sulfonyl)-n,n-diethyl-7,8-dimethoxy[1,2,3]triazolo[1,5-a]quinazolin-5-amine
DTXSID80659297
targocil
3-((4-chlorophenyl)sulfonyl)-n,n-diethyl-7,8-dimethoxy-[1,2,3]triazolo[1,5-a]quinazolin-5-amine
CS-8115
HY-18702
BS-14539
BCP29133
D80292
3-(4-chlorophenyl)sulfonyl-n,n-diethyl-7,8-dimethoxytriazolo[1,5-a]quinazolin-5-amine
A935174
3-[(4-chlorophenyl)sulfonyl]-n,n-diethyl-7,8-dimethoxy[1,2,3]triazolo[1,5-a]quinazolin-5-amine
AKOS037515543
AYB44321

Research Excerpts

Overview

Targocil targets the TarG subunit of the WTA translocase (TarGH) that transports WTA across the membrane to the wall.

ExcerptReferenceRelevance
"Targocil is a novel agent that targets the TarG subunit of the WTA translocase (TarGH) that transports WTA across the membrane to the wall."( Exposure of Staphylococcus aureus to Targocil Blocks Translocation of the Major Autolysin Atl across the Membrane, Resulting in a Significant Decrease in Autolysis.
Gatto, C; Tiwari, KB; Walker, S; Wilkinson, BJ, 2018)		1.48
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (10)

Assay IDTitleYearJournalArticle
AID465582Antibacterial activity against methicillin-sensitive Staphylococcus aureus RN6390 after 12 hrs by optical density plate reader method2010Bioorganic & medicinal chemistry letters, Mar-01, Volume: 20, Issue:5
Development of improved inhibitors of wall teichoic acid biosynthesis with potent activity against Staphylococcus aureus.
AID465588Antibacterial activity against Staphylococcus aureus RN4220 after 12 hrs by optical density plate reader method in presence of 50% fetal bovine serum2010Bioorganic & medicinal chemistry letters, Mar-01, Volume: 20, Issue:5
Development of improved inhibitors of wall teichoic acid biosynthesis with potent activity against Staphylococcus aureus.
AID465586Toxicity in CD1 mouse at 100 mg/kg, iv2010Bioorganic & medicinal chemistry letters, Mar-01, Volume: 20, Issue:5
Development of improved inhibitors of wall teichoic acid biosynthesis with potent activity against Staphylococcus aureus.
AID465584Antibacterial activity against methicillin-resistant Staphylococcus aureus COL after 12 hrs by optical density plate reader method2010Bioorganic & medicinal chemistry letters, Mar-01, Volume: 20, Issue:5
Development of improved inhibitors of wall teichoic acid biosynthesis with potent activity against Staphylococcus aureus.
AID465587Toxicity in CD1 mouse at 75 mg/kg, iv after 24 hrs2010Bioorganic & medicinal chemistry letters, Mar-01, Volume: 20, Issue:5
Development of improved inhibitors of wall teichoic acid biosynthesis with potent activity against Staphylococcus aureus.
AID465585Antibacterial activity against methicillin-resistant Staphylococcus aureus MW2 after 12 hrs by optical density plate reader method2010Bioorganic & medicinal chemistry letters, Mar-01, Volume: 20, Issue:5
Development of improved inhibitors of wall teichoic acid biosynthesis with potent activity against Staphylococcus aureus.
AID465578Antibacterial activity against Staphylococcus aureus RN4220 after 12 hrs by optical density plate reader method2010Bioorganic & medicinal chemistry letters, Mar-01, Volume: 20, Issue:5
Development of improved inhibitors of wall teichoic acid biosynthesis with potent activity against Staphylococcus aureus.
AID465583Antibacterial activity against methicillin-sensitive Staphylococcus aureus Newman after 12 hrs by optical density plate reader method2010Bioorganic & medicinal chemistry letters, Mar-01, Volume: 20, Issue:5
Development of improved inhibitors of wall teichoic acid biosynthesis with potent activity against Staphylococcus aureus.
AID465581Antibacterial activity against tarO deficient Staphylococcus aureus RN4220 assessed as growth inhibition at 100 uM after 12 hrs by optical density plate reader method2010Bioorganic & medicinal chemistry letters, Mar-01, Volume: 20, Issue:5
Development of improved inhibitors of wall teichoic acid biosynthesis with potent activity against Staphylococcus aureus.
AID465589Toxicity in Staphylococcus aureus Newman assessed as induction of mutation at 8 times MIC after 24 hrs2010Bioorganic & medicinal chemistry letters, Mar-01, Volume: 20, Issue:5
Development of improved inhibitors of wall teichoic acid biosynthesis with potent activity against Staphylococcus aureus.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (80.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 30.47

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index30.47 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index5.08 (4.65)
Search Engine Demand Index34.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (30.47)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
quinazolines
Quinazolines: A group of aromatic heterocyclic compounds that contain a bicyclic structure with two fused six-membered aromatic rings, a benzene ring and a pyrimidine ring.. quinazoline : A mancude organic heterobicyclic parent that is naphthalene in which the carbon atoms at positions 1 and 3 have been replaced by nitrogen atoms.. quinazolines : Any organic heterobicyclic compound based on a quinazoline skeleton and its substituted derivatives.		3.0340azaarene;
mancude organic heterobicyclic parent;
ortho-fused heteroarene;
quinazolines
triazoles
Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.		3.03401,2,3-triazole
glycidyl nitrate
glycidyl nitrate: a nitric oxide donor; structure in first source. peptidoglycan : A peptidoglycosaminoglycan formed by alternating residues of beta-(1->4)-linked N-acetylglucosamine and N-acetylmuramic acid {2-amino-3-O-[(S)-1-carboxyethyl]-2-deoxy-D-glucose} residues. Attached to the carboxy group of the muramic acid is a peptide chain of three to five amino acids.		2.0610
beta-lactams
2-azetidinone: structure in first source. azetidin-2-one : An unsubstituted beta-lactam compound.. beta-lactam : A lactam in which the amide bond is contained within a four-membered ring, which includes the amide nitrogen and the carbonyl carbon.		2.0710beta-lactam antibiotic allergen;
beta-lactam
(5-amino-3-triazolo[1,5-a]quinazolinyl)-(4-morpholinyl)methanone
[no description available]		2.0510quinazolines
muramidase
Muramidase: A basic enzyme that is present in saliva, tears, egg white, and many animal fluids. It functions as an antibacterial agent. The enzyme catalyzes the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrin. EC 3.2.1.17.		2.1710
ConditionIndicatedRelationship StrengthStudiesTrials
Autolysis
The spontaneous disintegration of tissues or cells by the action of their own autogenous enzymes.		07.5220