triazoles has been researched along with 4-(2-chlorophenyl)-2-(2-(4-isobutylphenyl)ethyl)-6,9-dimethyl-6h-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepine in 38 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 29 (76.32) | 18.2507 |
| 2000's | 8 (21.05) | 29.6817 |
| 2010's | 1 (2.63) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Iwahisa, Y; Okamoto, H; Terasawa, M | 1 |
| Katayama, K; Katayama, S; Sakuma, Y; Shirato, M; Tsunoda, H; Yamatsu, I | 1 |
| Harada, K; Katayama, K; Katayama, S; Muramoto, K; Sakuma, Y; Tsunoda, H | 1 |
| Ban, C; Hasegawa, M; Ihara, Y; Inamori, K; Itoh, H; Li, XM; Mori, T; Okagaki, A; Sagawa, N | 1 |
| Mikashima, H; Muramoto, Y; Setoguchi, M; Tahara, T; Takehara, S; Terasawa, M | 1 |
| Hirasawa, N; Mue, S; Ohuchi, K; Omata, M; Tsurufuji, S; Watanabe, M; Yagi, M | 1 |
| Clark, R; Harada, K; Horie, T; Katayama, S; Miyazawa, S; Muramoto, K; Okano, K; Sakuma, Y; Shimomura, N; Tsunoda, H | 1 |
| Aratani, H; Setoguchi, M; Tahara, T; Terasawa, M | 1 |
| Haruta, Y; Hozawa, S; Ishioka, S; Yamakido, M | 1 |
| Komatsu, H; Nagasawa, M; Okumoto, T | 1 |
| Fujimura, M; Matsuda, T; Ogawa, H; Saito, M | 2 |
| Arakida, Y; Hirasawa, N; Mue, S; Ohuchi, K; Sugidachi, A; Tanabe, J; Watanabe, M | 1 |
| Hara, N; Ichinose, M; Maeno, T; Sawada, M | 1 |
| Kawazoe, Y; Mizuta, H; Sagara, K; Shibata, M; Yamada, I | 1 |
| Ferby, I; Honda, Z; Ishiguro, S; Nakamura, M; Shimizu, T; Toyoshima, S; Waga, I | 1 |
| Ikeda, M; Kihara, T; Kogure, K; Matsuo, Y; Ninomiya, M; Onodera, H | 1 |
| Fujimura, M; Matsuda, T; Myou, S; Songür, N; Tsujiura, M | 1 |
| Fukuda, T; Makino, S; Sagara, H | 1 |
| Iwahisa, Y; Kagoshima, M; Terasawa, M; Yamaguchi, S | 1 |
| Iwahisa, Y; Kagoshima, M; Kawakami, Y; Terasawa, M; Tomomatsu, N; Yamaguchi, S | 2 |
| Iwahisa, Y; Kagoshima, M; Kawakami, Y; Matsuura, M; Terasawa, M; Tomomatsu, N; Yamaguchi, S | 1 |
| Kagoshima, M; Kohge, S; Terasawa, M; Yamaguchi, S | 1 |
| Akiyama, M; Ino, M; Miwa, M; Shimura, M; Sugatani, J; Suzuki, M; Suzuki, Y; Yamazaki, R | 1 |
| Kagoshima, M; Komatsu, H; Okumoto, T; Tomomatsu, N; Yamaguchi, S | 2 |
| Amano, M; Komatsu, H; Sugahara, K; Yamaguchi, S | 1 |
| Akiyama, Y; Iwane, S; Komatsu, H; Mizuki, M; Tsuda, T | 1 |
| Komatsu, H; Kusuhara, H; Matsuyuki, H; Sugahara, K; Terasawa, M; Yamaguchi, S | 1 |
| Komatsu, H; Tomomatsu, N; Yamaguchi, S | 1 |
| Fujimura, A; Kawaguchi, A; Sugimoto, K | 1 |
| Ida, S; Ishizuka, S; Kamanaka, M; Nakayama, K; Sasaki, H; Sekizawa, K; Suzuki, T; Yamaya, M | 1 |
| Makiyama, Y; Mitsui, Y; Tanaka, Y | 1 |
| Chao, YY; Jan, CR | 3 |
| Hashidate, T; Hirota, N; Nagamune, T; Nagase, T; Nakamura, M; Shimizu, T; Yamaguchi, S; Yamamoto, T; Yasuda, D | 1 |
1 review(s) available for triazoles and 4-(2-chlorophenyl)-2-(2-(4-isobutylphenyl)ethyl)-6,9-dimethyl-6h-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepine
| Article | Year |
|---|---|
[PAF receptor antagonist in asthma therapy].
Topics: Animals; Asthma; Azepines; Humans; Platelet Activating Factor; Triazoles | 1996 |
1 trial(s) available for triazoles and 4-(2-chlorophenyl)-2-(2-(4-isobutylphenyl)ethyl)-6,9-dimethyl-6h-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepine
| Article | Year |
|---|---|
Effects of a PAF antagonist, Y-24180, on bronchial hyperresponsiveness in patients with asthma.
Topics: Adult; Analysis of Variance; Asthma; Azepines; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cross-Over Studies; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Platelet Activating Factor; Platelet Aggregation Inhibitors; Triazoles | 1995 |
36 other study(ies) available for triazoles and 4-(2-chlorophenyl)-2-(2-(4-isobutylphenyl)ethyl)-6,9-dimethyl-6h-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepine
| Article | Year |
|---|---|
Suppression of the Arthus reaction by Y-24180, a potent and specific antagonist of platelet-activating factor.
Topics: Animals; Arthus Reaction; Azepines; Capillary Permeability; Disease Models, Animal; Female; Guinea Pigs; Male; Molecular Structure; Ovalbumin; Pancreatitis; Platelet Activating Factor; Rabbits; Rats; Rats, Inbred Strains; Skin; Skin Diseases; Triazoles | 1992 |
Pharmacological effects of oral E6123, a novel PAF antagonist, on biological changes induced by PAF inhalation in guinea pigs.
Topics: Administration, Oral; Analysis of Variance; Animals; Asthma; Azepines; Bronchial Hyperreactivity; Bronchoconstriction; Calcium; Eosinophils; Guinea Pigs; Lung; Male; Platelet Activating Factor; Triazoles | 1991 |
Inhibitory effects of a novel PAF antagonist E6123 on anaphylactic responses in passively and actively sensitized guinea pigs and passively sensitized mice.
Topics: Administration, Inhalation; Anaphylaxis; Animals; Antigens; Asthma; Azepines; Guinea Pigs; Male; Mice; Mice, Inbred ICR; Ovalbumin; Platelet Activating Factor; Propranolol; Pyrilamine; Triazoles | 1991 |
The involvement of platelet-activating factor in thrombocytopenia and follicular rupture during gonadotropin-induced superovulation in immature rats.
Topics: Animals; Azepines; Chorionic Gonadotropin; Female; Gonadotropins, Equine; Indomethacin; Ovulation; Ovulation Induction; Platelet Activating Factor; Platelet Activation; Platelet Count; Rats; Rats, Inbred Strains; Superovulation; Thrombocytopenia; Triazoles; Vena Cava, Inferior | 1991 |
Pharmacological actions of Y-24180, a new specific antagonist of platelet activating factor (PAF): II. Interactions with PAF and benzodiazepine receptors.
Topics: Animals; Azepines; Binding, Competitive; Blood Platelets; Brain; Diazepam; Humans; In Vitro Techniques; Male; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rabbits; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, GABA-A; Triazoles | 1990 |
Stimulation of neutrophil adherence to vascular endothelial cells by histamine and thrombin and its inhibition by PAF antagonists and dexamethasone.
Topics: Animals; Azepines; Cell Adhesion; Cells, Cultured; Dexamethasone; Endothelium, Vascular; Furans; Histamine; Humans; In Vitro Techniques; Indomethacin; Male; Neutrophils; Phospholipid Ethers; Platelet Activating Factor; Rats; Rats, Inbred Strains; Thrombin; Triazoles | 1991 |
Effects of a novel PAF antagonist, E6123, on PAF-induced biological responses.
Topics: Animals; Azepines; Blood Platelets; Bronchoconstriction; Bronchoconstrictor Agents; Dogs; Dose-Response Relationship, Drug; Guinea Pigs; Humans; Platelet Activating Factor; Platelet Aggregation; Triazoles | 1990 |
Pharmacological actions of Y-24180: I. A potent and specific antagonist of platelet-activating factor.
Topics: Anaphylaxis; Animals; Azepines; Blood Pressure; Bronchi; Female; Guinea Pigs; Hematocrit; Male; Mice; Mice, Inbred ICR; Platelet Activating Factor; Rats; Rats, Inbred Lew; Triazoles | 1990 |
Inhibition of leukocyte adhesion to endothelial cells of human umbilical vein by Y-24180, an antagonist of platelet-activating factor.
Topics: Animals; Antigens, CD; Azepines; CD18 Antigens; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; E-Selectin; Edema; Endothelium, Vascular; Guinea Pigs; Humans; Intercellular Adhesion Molecule-1; Leukocytes; Male; Mice; Mice, Inbred BALB C; Platelet Activating Factor; Triazoles; Umbilical Veins | 1993 |
Role of thromboxane A2 and platelet-activating factor in allergic bronchoconstriction in guinea pig airway in vivo.
Topics: Administration, Inhalation; Animals; Antigens; Asthma; Azepines; Bridged Bicyclo Compounds; Bronchoconstriction; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Guinea Pigs; Hypersensitivity; Male; Platelet Activating Factor; Receptors, Prostaglandin; Thromboxane A2; Triazoles | 1995 |
Pharmacological analysis of neutrophil chemotactic factor production by leucocytes and roles of PAF in allergic inflammation in rats.
Topics: Animals; Azepines; Benzoquinones; Cells, Cultured; Culture Media, Conditioned; Dose-Response Relationship, Drug; Furans; Hypersensitivity; Immunization; Interleukin-8; Isoelectric Focusing; Leukocytes; Lipoxygenase Inhibitors; Phospholipid Ethers; Platelet Activating Factor; Rats; Triazoles | 1994 |
A flow cytometric assay reveals an enhancement of phagocytosis by platelet activating factor in murine peritoneal macrophages.
Topics: Animals; Azepines; Calcium; Female; Flow Cytometry; In Vitro Techniques; Latex; Macrophages, Peritoneal; Male; Mice; Mice, Inbred BALB C; Phagocytosis; Phospholipid Ethers; Platelet Activating Factor; Triazoles | 1994 |
Gastrointestinal physiology-regulated dogs: utilization of a bioavailability study of a new thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]-diazepine, an antagonist of platelet-activating factor, and its preparations.
Topics: Administration, Oral; Animals; Atropine; Azepines; Biological Availability; Chromatography, High Pressure Liquid; Dogs; Dosage Forms; Humans; Injections, Intravenous; Intestinal Absorption; Male; Pentagastrin; Platelet Activating Factor; Solubility; Tablets; Triazoles | 1994 |
Two distinct signal transduction pathways for the activation of guinea-pig macrophages and neutrophils by endotoxin.
Topics: Animals; Azepines; Calcium; Chloride Channels; Cloning, Molecular; Endotoxins; Escherichia coli; Female; Guinea Pigs; L Cells; Lipid A; Lipopolysaccharides; Macrophage Activation; Macrophages, Peritoneal; Membrane Potentials; Mice; Neutrophils; Oocytes; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Recombinant Proteins; Signal Transduction; Superoxides; Triazoles; Tumor Necrosis Factor-alpha; Xenopus laevis | 1993 |
Role of leukotrienes and platelet activating factor in allergic bronchoconstriction and their interactions in guinea pig airway in vivo.
Topics: Animals; Asthma; Azepines; Bronchoconstriction; Bronchodilator Agents; Guinea Pigs; Leukotriene Antagonists; Leukotrienes; Male; Platelet Activating Factor; Pyridines; Pyrimidinones; Respiratory Hypersensitivity; Tetrazoles; Triazoles | 1993 |
Role of platelet-activating factor and thromboxane A2 in radical production during ischemia and reperfusion of the rat brain.
Topics: Animals; Ascorbic Acid; Azepines; Brain; Brain Ischemia; Bridged Bicyclo Compounds; Dehydroascorbic Acid; Extracellular Space; Fatty Acids, Monounsaturated; Free Radicals; Male; Oxygen; Partial Pressure; Peroxidase; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Reactive Oxygen Species; Reperfusion; Thromboxane A2; Triazoles | 1996 |
Involvement of PAF in postallergic propranolol-induced bronchoconstriction in guinea-pigs.
Topics: Administration, Inhalation; Adrenergic beta-Antagonists; Anesthesia, General; Animals; Antigens; Asthma; Azepines; Bronchoconstriction; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Hypersensitivity; Immunization; Inflammation Mediators; Injections, Intravenous; Male; Platelet Activating Factor; Propranolol; Respiration, Artificial; Time Factors; Triazoles | 1996 |
Effect of Y-24180, a platelet-activating factor-receptor antagonist, on the antigen-induced airway microvascular leakage in guinea pigs.
Topics: Animals; Antigens; Azepines; Bronchi; Capillary Permeability; Dose-Response Relationship, Drug; Guinea Pigs; Linear Models; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Trachea; Triazoles | 1996 |
Effects of Y-24180, a long-acting and potent antagonist to platelet-activating factor, on immediate asthmatic response in guinea pigs.
Topics: Animals; Anti-Asthmatic Agents; Asthma; Azepines; Benzoquinones; Bronchodilator Agents; Chromones; Drug Interactions; Drug Therapy, Combination; Guinea Pigs; Heptanoic Acids; Male; Methacrylates; Platelet Activating Factor; Theophylline; Triazoles | 1997 |
Suppressive effects of Y-24180, a receptor antagonist to platelet activating factor (PAF), on antigen-induced asthmatic responses in guinea pigs.
Topics: Administration, Oral; Aerosols; Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Asthma; Azepines; Benzoquinones; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchodilator Agents; Chromones; Enzyme Inhibitors; Guinea Pigs; Heptanoic Acids; Histamine Antagonists; Leukotriene Antagonists; Male; Methacrylates; Ovalbumin; Platelet Membrane Glycoproteins; Pyrilamine; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Serine Proteinase Inhibitors; Signal Transduction; Theophylline; Thromboxane-A Synthase; Triazoles | 1997 |
Effect of Y-24180, a long-acting antagonist to platelet-activating factor (PAF), on PAF-induced reactions: a relationship between the partial structure of the compound and its duration of the action.
Topics: Acetylcholine; Administration, Oral; Animals; Azepines; Binding Sites; Blood Platelets; Bradykinin; Bronchial Hyperreactivity; Bronchoconstriction; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; Injections, Intravenous; Leukotriene D4; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Serotonin; Structure-Activity Relationship; Triazoles | 1997 |
Suppressive effects of Y-24180, a long-acting antagonist for platelet-activating factor, on allergic pulmonary eosinophilia in mice.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Azepines; Bronchoalveolar Lavage Fluid; Eosinophils; Interleukin-5; Lung; Male; Mice; Mice, Inbred BALB C; Platelet Aggregation Inhibitors; Prednisolone; Pulmonary Eosinophilia; Triazoles | 1997 |
Continuous binding of the PAF molecule to its receptor is necessary for the long-term aggregation of platelets.
Topics: Animals; Azepines; Blood Platelets; Humans; In Vitro Techniques; Kinetics; Neutrophils; P-Selectin; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Thiazolidines; Triazoles | 1998 |
Effect of Y-24180, an antagonist at platelet-activating factor (PAF) receptors, on IgE-mediated cutaneous reactions in mice.
Topics: Animals; Azepines; Dermatitis, Allergic Contact; Dinitrofluorobenzene; Ear; Eosinophils; Female; Immunoglobulin E; Kinetics; Macrophages; Mice; Mice, Inbred BALB C; Monocytes; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Prednisolone; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles | 1998 |
Effects of Y-24180, a receptor antagonist to platelet-activating factor, on allergic cutaneous eosinophilia in mice.
Topics: Animals; Azepines; Cytokines; Eosinophilia; Hypersensitivity; Male; Mice; Mice, Inbred BALB C; Platelet Activating Factor; Skin Diseases; Triazoles | 1999 |
Inhibition of activation of human peripheral blood eosinophils by Y-24180, an antagonist to platelet-activating factor receptor.
Topics: Azepines; Eosinophils; Humans; Intercellular Adhesion Molecule-1; Leukotriene B4; Macrophage-1 Antigen; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles | 1999 |
Inhibition of eosinophil activation in bronchoalveolar lavage fluid from atopic asthmatics by Y-24180, an antagonist to platelet-activating factor.
Topics: Adult; Antigens, CD; Asthma; Azepines; Blood Proteins; Bronchi; Bronchoalveolar Lavage Fluid; Eosinophil Granule Proteins; Eosinophils; Female; Fibronectins; Humans; Integrin alpha1; Intercellular Adhesion Molecule-1; Leukocyte Count; Macrophage-1 Antigen; Male; Middle Aged; Platelet Activating Factor; Ribonucleases; Triazoles | 1999 |
Y-24180, an antagonist of platelet-activating factor, suppresses interleukin 5 production in cultured murine th(2)cells and human peripheral blood mononuclear cells.
Topics: Animals; Azepines; Cells, Cultured; Gene Expression; Humans; Interleukin-5; Leukocytes, Mononuclear; Mice; Platelet Activating Factor; Platelet Aggregation Inhibitors; Th2 Cells; Triazoles | 2000 |
Effect of Y-24180, a receptor antagonist to platelet-activating factor (PAF), on allergic cutaneous reactions in actively sensitized mice.
Topics: Administration, Oral; Administration, Topical; Allergens; Animals; Anti-Allergic Agents; Anti-Inflammatory Agents; Arylsulfonates; Azepines; Dermatitis, Allergic Contact; Ear; Eosinophils; Histamine H1 Antagonists; Hydrocortisone; Immunoglobulin E; Immunoglobulin G; Ketotifen; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Ovalbumin; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Sulfonium Compounds; Time Factors; Triazoles | 2000 |
Preventive effect of platelet-activating factor antagonist, Y-24180, against cyclosporine-induced acute nephrotoxicity.
Topics: Animals; Azepines; Cyclosporine; Dose-Response Relationship, Drug; Endothelin-1; Hemodynamics; Immunosuppressive Agents; Kidney; Male; Platelet Activating Factor; Rats; Rats, Wistar; Thromboxane B2; Triazoles | 2001 |
Acid exposure stimulates the adherence of Streptococcus pneumoniae to cultured human airway epithelial cells: effects on platelet-activating factor receptor expression.
Topics: Aged; Antibodies; Antioxidants; Azepines; Bacterial Adhesion; Cells, Cultured; Epithelial Cells; Female; Gene Expression; Humans; Hydrochloric Acid; Interleukin-1; Male; Middle Aged; Neutralization Tests; NF-kappa B; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pneumococcal Infections; Pneumonia, Aspiration; Pyrrolidines; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Messenger; Streptococcus pneumoniae; Thiocarbamates; Trachea; Triazoles | 2001 |
Anti-CD44 monoclonal antibody (IM7) induces murine systemic shock mediated by platelet activating factor.
Topics: Anaphylaxis; Animals; Anti-Allergic Agents; Antibodies, Monoclonal; Azepines; Capillary Permeability; Cyproheptadine; Diphenhydramine; Erythrocytes; Hyaluronan Receptors; Hypotension; Immunoglobulin Fab Fragments; Immunoglobulin G; Injections, Intravenous; Male; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Platelet Activating Factor; Triazoles | 2002 |
Effect of Y-24180 on Ca2+ movement and proliferation in renal tubular cells.
Topics: Adenosine Triphosphate; Animals; Azepines; Calcium; Calcium Signaling; Cell Division; Cells, Cultured; Chelating Agents; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estrenes; Fura-2; Kidney Tubules; Pyrrolidinones; Thapsigargin; Triazoles; Type C Phospholipases | 2004 |
Novel effect of Y-24180, a presumed specific platelet activation factor receptor antagonist, on Ca2+ levels and growth of human prostate cancer cells.
Topics: Adenosine Triphosphate; Azepines; Calcium; Calcium Signaling; Cell Proliferation; Dihydropyridines; Diltiazem; Enzyme Inhibitors; Fura-2; Humans; Male; Phorbol Esters; Platelet Membrane Glycoproteins; Prostatic Neoplasms; Protein Kinase C; Receptors, G-Protein-Coupled; Signal Transduction; Thapsigargin; Triazoles; Tumor Cells, Cultured; Verapamil | 2004 |
Novel effect of Y-24180, a presumed specific platelet-activating factor receptor antagonist, on Ca2+ levels and growth of human osteosarcoma cells.
Topics: Azepines; Calcium; Calcium Signaling; Cell Death; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Growth Inhibitors; Humans; Osteosarcoma; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Triazoles | 2005 |
Amino acid residues critical for endoplasmic reticulum export and trafficking of platelet-activating factor receptor.
Topics: Amino Acid Substitution; Animals; Azepines; CHO Cells; Cricetinae; Cricetulus; Endoplasmic Reticulum; Gene Expression Regulation; HeLa Cells; Humans; Mutation, Missense; Peptide Mapping; Phospholipid Ethers; Platelet Membrane Glycoproteins; Proline; Protein Transport; Receptors, G-Protein-Coupled; Triazoles | 2010 |