triazoles has been researched along with pf 00868554 in 15 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 14 (93.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chau, F; Drowns, M; Gonzalez, J; Herlihy, KJ; Hickey, M; Hunter, R; Jewell, T; Lewis, C; Li, H; Linton, A; Ludlum, S; Nonomiya, J; Parge, H; Patel, L; Rahavendran, SV; Shi, ST; Skor, H; Tatlock, J; Yu, X | 1 |
| Beaulieu, PL | 1 |
| Graham, EJ; Hammond, J; Hunt, R; Pickford, C; Shaw, SM; Targett-Adams, P; Westby, M | 1 |
| Hammond, JL; Jagannatha, S; Kantaridis, C; Neelakantan, S; Purohit, VS; Simpson, P; Thompson, R; Troke, PJ; Wagner, F | 1 |
| Beigelman, L; Blatt, L; Cai, H; Deval, J; Fan, B; Kao, CC; Ranjith-Kumar, CT; Smith, DB; Soulard, C; Yi, G | 1 |
| Craig, C; Gore, K; Hammond, J; Lewis, M; Simpson, P; Troke, PJ; Westby, M | 1 |
| Altaf, A; Fridell, RA; Gao, M; Huang, H; Huang, X; Jia, L; Nower, PT; O'Boyle, DR; Qiu, D; Sun, JH; Valera, L; Wang, C | 1 |
| Sluggett, GW; Strohmeyer, HE | 1 |
| Appleby, TC; Bidgood, AM; Byun, D; Canales, E; Clarke, MO; Doerffler, E; Eng, S; Fenaux, M; Hashash, A; Krawczyk, SH; Lazerwith, SE; Leavitt, SA; Lee, YJ; Lew, W; Liu, Q; Mabery, EM; Matles, M; Mertzman, M; Morganelli, P; Murray, BP; Mwangi, J; Tian, Y; Watkins, WJ; Xu, L; Ye, H; Zhang, J | 1 |
| Jiao, P; Jin, N; Liu, H; Shen, Y; Xue, W | 1 |
| Douglas, MW; Eltahla, AA; Tay, E; White, PA | 1 |
| Chen, BZ; Guo, C; Ji, M; Wang, H | 1 |
| Deredge, D; Johnson, KA; Li, J; Wintrode, PL | 1 |
| Bessa, LM; Cantrelle, FX; Dujardin, M; Hanoulle, X; Landrieu, I; Launay, H; Lippens, G; Schneider, R | 1 |
| Abdurakhmanov, E; Danielson, UH; Solbak, SMØ; Vedeler, A | 1 |
1 review(s) available for triazoles and pf 00868554
| Article | Year |
|---|---|
Filibuvir, a non-nucleoside NS5B polymerase inhibitor for the potential oral treatment of chronic HCV infection.
Topics: Administration, Oral; Animals; Antiviral Agents; Hepacivirus; Hepatitis C, Chronic; Humans; Nucleic Acid Synthesis Inhibitors; Pyrones; RNA-Dependent RNA Polymerase; Triazoles; Viral Nonstructural Proteins | 2010 |
3 trial(s) available for triazoles and pf 00868554
| Article | Year |
|---|---|
Antiviral activity of the hepatitis C virus polymerase inhibitor filibuvir in genotype 1-infected patients.
Topics: Adult; Antiviral Agents; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C; Humans; Interferon alpha-2; Interferon-alpha; Male; Middle Aged; Polyethylene Glycols; Pyrones; Recombinant Proteins; Ribavirin; RNA, Viral; Treatment Outcome; Triazoles; Viral Nonstructural Proteins | 2011 |
Characterization of resistance to the nonnucleoside NS5B inhibitor filibuvir in hepatitis C virus-infected patients.
Topics: Antiviral Agents; Base Sequence; Cell Line, Tumor; Cloning, Molecular; Drug Resistance, Viral; Hepacivirus; Hepatitis C, Chronic; Humans; Inhibitory Concentration 50; Methionine; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Pyrones; Replicon; RNA-Dependent RNA Polymerase; Transfection; Triazoles; Viral Nonstructural Proteins; Virus Replication | 2012 |
Preclinical characterization of GS-9669, a thumb site II inhibitor of the hepatitis C virus NS5B polymerase.
Topics: Animals; Antiviral Agents; Cell Line, Tumor; Dogs; Drug Resistance, Viral; Furans; Hepacivirus; Humans; Interferon-alpha; Male; Mutation; Polymorphism, Single Nucleotide; Pyrones; Rats; Rats, Sprague-Dawley; Ribavirin; RNA-Dependent RNA Polymerase; Thiophenes; Triazoles; Viral Nonstructural Proteins | 2013 |
11 other study(ies) available for triazoles and pf 00868554
| Article | Year |
|---|---|
Discovery of (R)-6-cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one (PF-00868554) as a potent and orally available hepatitis C virus polymerase inhibitor.
Topics: Administration, Oral; Animals; Antiviral Agents; Crystallography, X-Ray; Cytochrome P-450 CYP2D6 Inhibitors; Dogs; Hepacivirus; Macaca fascicularis; Microsomes, Liver; Models, Molecular; Pyrones; Rats; Rats, Sprague-Dawley; RNA-Dependent RNA Polymerase; Solubility; Stereoisomerism; Structure-Activity Relationship; Triazoles | 2009 |
Colony-forming assays reveal enhanced suppression of hepatitis C virus replication using combinations of direct-acting antivirals.
Topics: Antiviral Agents; Cell Line; Colony-Forming Units Assay; Drug Synergism; Hepacivirus; Hepatocytes; Humans; Microbial Sensitivity Tests; Pyrones; Triazoles; Viral Nonstructural Proteins; Virus Replication | 2011 |
Biochemical study of the comparative inhibition of hepatitis C virus RNA polymerase by VX-222 and filibuvir.
Topics: Antiviral Agents; Binding Sites; Cell Line, Tumor; Cyclohexanols; Drug Resistance, Viral; Enzyme Inhibitors; Hepacivirus; Humans; Models, Molecular; Mutation; Pyrones; Replicon; RNA-Dependent RNA Polymerase; RNA, Viral; Templates, Genetic; Thiophenes; Triazoles | 2012 |
Hepatitis C virus RNA elimination and development of resistance in replicon cells treated with BMS-790052.
Topics: Amino Acid Substitution; Antiviral Agents; Cell Line, Tumor; Drug Resistance, Viral; Genotype; Hepacivirus; Humans; Inhibitory Concentration 50; Interferon-alpha; Phenotype; Polyethylene Glycols; Pyrones; Recombinant Proteins; Replicon; RNA-Dependent RNA Polymerase; Sequence Deletion; Triazoles; Viral Nonstructural Proteins; Virus Replication | 2012 |
Determination and control of TEMPO, a potentially genotoxic free radical reagent used in the synthesis of filibuvir.
Topics: Antiviral Agents; Cyclic N-Oxides; Free Radicals; Gas Chromatography-Mass Spectrometry; Indicators and Reagents; Limit of Detection; Mutagens; Pyrones; RNA-Dependent RNA Polymerase; Triazoles | 2012 |
Understanding the drug resistance mechanism of hepatitis C virus NS5B to PF-00868554 due to mutations of the 423 site: a computational study.
Topics: Amino Acid Substitution; Antiviral Agents; Binding Sites; Crystallography, X-Ray; Drug Resistance, Viral; Hepacivirus; Molecular Dynamics Simulation; Mutation; Pyrones; RNA-Dependent RNA Polymerase; Triazoles; Viral Nonstructural Proteins; Virus Replication | 2014 |
Cross-genotypic examination of hepatitis C virus polymerase inhibitors reveals a novel mechanism of action for thumb binders.
Topics: Antiviral Agents; Benzimidazoles; Benzofurans; Cyclohexanols; Drug Resistance, Viral; Enzyme Inhibitors; Genotype; Hepacivirus; Humans; Purines; Pyridazines; Pyrones; Recombinant Proteins; Replicon; RNA-Dependent RNA Polymerase; Structure-Activity Relationship; Sulfonamides; Thiophenes; Triazoles; Viral Proteins | 2014 |
Computational study on the drug resistance mechanism of HCV NS5B RNA-dependent RNA polymerase mutants V494I, V494A, M426A, and M423T to Filibuvir.
Topics: Antiviral Agents; Drug Resistance, Viral; Hepacivirus; Molecular Dynamics Simulation; Mutation; Pyrones; RNA-Dependent RNA Polymerase; Thermodynamics; Triazoles | 2015 |
Hydrogen/Deuterium Exchange Kinetics Demonstrate Long Range Allosteric Effects of Thumb Site 2 Inhibitors of Hepatitis C Viral RNA-dependent RNA Polymerase.
Topics: Allosteric Regulation; Binding Sites; Deuterium Exchange Measurement; Furans; Hepacivirus; Kinetics; Pyrones; RNA-Dependent RNA Polymerase; RNA, Viral; Thiophenes; Triazoles; Viral Nonstructural Proteins | 2016 |
NMR reveals the intrinsically disordered domain 2 of NS5A protein as an allosteric regulator of the hepatitis C virus RNA polymerase NS5B.
Topics: Allosteric Regulation; Allosteric Site; Antiviral Agents; Enzyme Inhibitors; Gene Deletion; Hepacivirus; Intrinsically Disordered Proteins; Isoleucine; Models, Molecular; Mutagenesis, Site-Directed; Nuclear Magnetic Resonance, Biomolecular; Oligoribonucleotides; Peptide Fragments; Point Mutation; Protein Conformation; Protein Interaction Domains and Motifs; Protein Refolding; Pyrones; Recombinant Proteins; RNA-Dependent RNA Polymerase; Solubility; Triazoles; Viral Nonstructural Proteins | 2017 |
Characterization of interactions between hepatitis C virus NS5B polymerase, annexin A2 and RNA - effects on NS5B catalysis and allosteric inhibition.
Topics: Allosteric Site; Animals; Annexin A2; Antiviral Agents; Enzyme Inhibitors; Hepacivirus; Hepatitis C; Humans; Kinetics; Protein Binding; Pyrones; RNA-Binding Proteins; RNA-Dependent RNA Polymerase; RNA, Viral; Substrate Specificity; Surface Plasmon Resonance; Triazoles; Viral Nonstructural Proteins | 2017 |