leflutrozole: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 126735 |
| CHEMBL ID | 225550 |
| SCHEMBL ID | 6064562 |
| MeSH ID | M0215982 |
| Synonym |
|---|
| cgp 47645 |
| CHEMBL225550 |
| 4-[(4-cyanophenyl)-fluoro-(1,2,4-triazol-1-yl)methyl]benzonitrile |
| benzonitrile, 4,4'-(fluoro-1h-1,2,4-triazol-1-ylmethylene)bis- |
| rcx0ie6ejz , |
| cgp-47645 |
| leflutrozole |
| unii-rcx0ie6ejz |
| 143030-47-1 |
| SCHEMBL6064562 |
| leflutrozole [inn] |
| 4,4'-(fluoro-1h-1,2,4-triazol-1-ylmethylene)bisbenzonitrile |
| cgp 47,645 |
| leflutrozole [who-dd] |
| DTXSID80162296 |
| 4,4'-(fluoro(1h-1,2,4-triazol-1-yl)methylene)dibenzonitrile |
| Q27288053 |
| AKOS040751110 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Aromatase | Homo sapiens (human) | IC50 (µMol) | 0.0617 | 0.0000 | 1.2904 | 10.0000 | AID282900 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| negative regulation of chronic inflammatory response | Aromatase | Homo sapiens (human) |
| steroid biosynthetic process | Aromatase | Homo sapiens (human) |
| estrogen biosynthetic process | Aromatase | Homo sapiens (human) |
| androgen catabolic process | Aromatase | Homo sapiens (human) |
| syncytium formation | Aromatase | Homo sapiens (human) |
| negative regulation of macrophage chemotaxis | Aromatase | Homo sapiens (human) |
| sterol metabolic process | Aromatase | Homo sapiens (human) |
| female genitalia development | Aromatase | Homo sapiens (human) |
| mammary gland development | Aromatase | Homo sapiens (human) |
| uterus development | Aromatase | Homo sapiens (human) |
| prostate gland growth | Aromatase | Homo sapiens (human) |
| testosterone biosynthetic process | Aromatase | Homo sapiens (human) |
| positive regulation of estradiol secretion | Aromatase | Homo sapiens (human) |
| female gonad development | Aromatase | Homo sapiens (human) |
| response to estradiol | Aromatase | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| iron ion binding | Aromatase | Homo sapiens (human) |
| steroid hydroxylase activity | Aromatase | Homo sapiens (human) |
| electron transfer activity | Aromatase | Homo sapiens (human) |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | Aromatase | Homo sapiens (human) |
| oxygen binding | Aromatase | Homo sapiens (human) |
| heme binding | Aromatase | Homo sapiens (human) |
| aromatase activity | Aromatase | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| endoplasmic reticulum | Aromatase | Homo sapiens (human) |
| endoplasmic reticulum membrane | Aromatase | Homo sapiens (human) |
| membrane | Aromatase | Homo sapiens (human) |
| endoplasmic reticulum | Aromatase | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID282900 | Inhibition of human placental microsome CYP19 | 2005 | Journal of medicinal chemistry, Nov-17, Volume: 48, Issue:23 | Enantioselective nonsteroidal aromatase inhibitors identified through a multidisciplinary medicinal chemistry approach. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (57.14) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 1 (12.50%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (87.50%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Article | Year |
|---|---|
| Effect of estrogen deprivation on the reproductive physiology of male and female primates. The Journal of steroid biochemistry and molecular biology, Volume: 61, Issue: 3-6 | 1997 |
| [information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | |