Central Nervous System Syphilis

Infections of the central nervous system caused by TREPONEMA PALLIDUM which present with a variety of clinical syndromes. The initial phase of infection usually causes a mild or asymptomatic meningeal reaction. The meningovascular form may present acutely as BRAIN INFARCTION. The infection may also remain subclinical for several years. Late syndromes include general paresis; TABES DORSALIS; meningeal syphilis; syphilitic OPTIC ATROPHY; and spinal syphilis. General paresis is characterized by progressive DEMENTIA; DYSARTHRIA; TREMOR; MYOCLONUS; SEIZURES; and Argyll-Robertson pupils. (Adams et al., Principles of Neurology, 6th ed, pp722-8)

Synonym
Paralysis, General
Paretic Neurosyphilis
Secondary Neurosyphilis
Syphilis, CNS
Syphilis, Central Nervous System
General Paralysis
General Paralysis of the Insane
General Paresis
Central Nervous System Syphilis
Juvenile Paresis
Neurosyphilis
General Paresis of the Insane
Neurosyphilis, Asymptomatic
Neurosyphilis, Gummatous
Neurosyphilis, Juvenile
Neurosyphilis, Secondary
Neurosyphilis, Symptomatic

Excerpt	Reference
"Unsuspected neurosyphilis is relatively common in our population of asymptomatic HIV+ subjects and may be responsible for neurological disease in a significant minority of neurologically symptomatic HIV+ persons."	( Berger, JR, 1991)
"Specifically, neurosyphilis is encountered much earlier in such patients."	( Levy, JH; Liss, RA; Maguire, AM, 1989)
"A case of neurosyphilis is described."	( Eide, N; Skjeldal, O, 1984)
"Juvenile neurosyphilis is rare and may be arrested or modified in the early stage by antibiotic treatment for intercurrent infections."	( Mason, R; Wiggelinkhuizen, J, 1980)
"If neurosyphilis is diagnosed early enough, a timely effective treatment may not only prevent further progression of the disease but also allow complete recovery."	( Lee, CH; Lin, WC; Liu, JW; Lu, CH, 2009)
"Neurosyphilis is still characterized by clinical polymorphism and there are significant differences in its epidemiological, clinical and laboratory profile when HIV-infected patients are compared with HIV-negative patients."	( Gitaí, LL; Jaláli, PS; Takayanagui, OM, 2009)
"Neurosyphilis is still a significant medical problem in developing countries and syphilitic ocular manifestations are often not diagnosed due to the lack of typical characteristics."	( Bandettini di Poggio, M; Bandini, F; Capello, E; Mazzarello, G; Primavera, A; Schenone, A; Viscoli, C, 2010)
"Asymptomatic neurosyphilis is more difficult to diagnose in human immunodeficiency virus (HIV)-infected patients because HIV itself can cause cerebrospinal fluid (CSF) pleocytosis."	( Lukehart, SA; Marra, CM; Maxwell, CL; Sahi, SK; Tantalo, LC, 2010)
"Although Lissauer's general paresis is a rare form of neurosyphilis, it is important to distinguish this disease in case of progressive dementia and focal neurological signs."	( Arahata, S; Araki, E; Fujii, N; Furuya, H; Syouzaki, T, 2010)
"We conclude that neurosyphilis is a relevant differential diagnosis in patients developing severe psychiatric symptoms in old age."	( Güler, E; Leyhe, T, 2011)
"Neurosyphilis is a common but often missed disease worldwide, mainly because it has many manifestations making its diagnosis difficult."	( Kyebambe, PS, 2010)
"General paresis of the insane is a late and severe form of neurosyphilis characterized by nonspecific neuropsychiatric symptoms."	( Barbosa, IG; de Macedo, DL; Gomez, RS; Teixeira, AL; Vale, TC, 2012)
"Early neurosyphilis are mostly represented by uveitis or cranial nerves lesions."	( Dupin, N; Farhi, D, 2013)
"Neurosyphilis is a tertiary form of syphilis and is caused by the spirochete Treponema pallidum."	( Hogebrug, J; Koopmans, PP; Schellekens, A; van Oostrom, I, 2013)
"The diagnosis of neurosyphilis is more difficult because of the alteration of cerebrospinal fluid (CSF) presentation by the HIV itself."	( Chen, JK; Chen, YS; Cheng, YJ; Lee, SS; Sy, CL; Tsai, HC; Wu, KS; Ye, SY, 2014)
"Neurosyphilis is a rare manifestation of this sexually transmitted disease for which we performed a retrospective study and analyzed clinical manifestations."	( Argemi, X; Chanson, JB; Christmann, D; De Martino, S; Douiri, N; Hansmann, Y; Lefebvre, N; Martin, M; Sauer, A, 2017)
"Neurosyphilis is a rare disease that until the 2000s was almost eradicated due to population awareness of HIV and efficient treatment."	( Aizenstein, O; Gadoth, A; Mina, Y; Piura, Y, 2019)
"Neurosyphilis is an infection of the central nervous system, caused by Treponema pallidum, a spirochete capable of infecting almost any organ or tissue in the body causing neurological complications due to the infection."	( Buitrago-Garcia, D; Conterno, LO; Jimenez, A; Martí-Carvajal, AJ; Pardo, R, 2019)
"Neurosyphilis is a chronic central nervous system infectious disease caused by Treponema pallidum."	( Huang, S; Huang, Z; Li, P; Li, Q; Luo, R; Nie, T; Qi, S; Xu, Y; Zhang, Q, 2019)
"Neurosyphilis is a chronic infection of the central nervous system that is commonly found in adult with long latency periods."	( Li, Y; Pan, R; Shi, M; Yang, B; Yang, D; Zhong, L; Zhou, Y; Zhu, Y, 2019)
"Neurosyphilis is still a significant medical problem in developing countries, and its occurrence in HIV infection is the reason for a growing number of new cases in developed countries."	( Kissani, N; Louhab, N; Nafia, S; Zahlane, S, 2021)

Excerpt	Reference
"Neurosyphilis has protean clinical manifestations, including epilepsy."	( Chandramuki, A; Harish, T; Murthy, P; Nagarathna, S; Sinha, S; Taly, AB, 2008)
"Neurosyphilis has become an uncommon diagnosis in the current era."	( Garg, D; Pandit, AK; Srivastava, AK; Vibha, D, 2019)
"Patients with neurosyphilis have cellular immune dysfunction, and their immune response involves CXCL8, CXCL10 and Th1 / Th2 cytokines."	( Chen, W; Hua, YH; Li, ZH; Lu, Y; Yan, N; Yu, XY, 2020)

Excerpt	Reference
"Because neurosyphilis may progress despite therapy with the recommended penicillin regimens, 15 subjects with positive tests for syphilis in the serum and cerebrospinal fluid (CSF) were studied."	( Bird, P; Griffiths, W; Jackson, R; Mohr, JA; Riddle, J; Saadah, H, 1976)
"In a 53-year old male suffering from paretic neurosyphilis, SPECT-investigations were performed before and after treatment with high doses of Penicillin G."	( Eber, O; Költringer, P; Leblhuber, F; Lind, P; Reisecker, F, 1992)
"Sixty-two patients with symptomatic neurosyphilis were treated with 20 or 24 megaunits of intravenous penicillin G daily for 15 to 30 days."	( Nitrini, R; Spina-França, A, 1987)
"The authors present two patients with neurosyphilis who presented with psychiatric disorders and who both benefited from penicillin therapy."	( Eviatar, J; Sirota, P; Spivak, B, 1989)
"Sixty-two patients with symptomatic neurosyphilis were treated with 20 or 24 megaunits of intravenous penicillin G daily for 15 to 30 days."	( Nitrini, R; Spina-França, A, 1987)
"Recommendations for treatment of neurosyphilis and reasons for renewed debate are briefly reviewed and discussed."	( Callanan, JJ; Forder, AA; Philcox, DV, 1987)
"Two patients developed neurosyphilis after treatment of latent syphilis with intramuscular benzathine penicillin."	( Jørgensen, J; Tikjøb, G; Weismann, K, 1986)
"We studied an unusual case of neurosyphilis and developed a rational basis for antibiotic treatment of this condition."	( Feldman, RG; Harrigan, EP; McLaughlin, TJ, 1984)
"Juvenile neurosyphilis is rare and may be arrested or modified in the early stage by antibiotic treatment for intercurrent infections."	( Mason, R; Wiggelinkhuizen, J, 1980)
"A co-existing neurosyphilis was treated intravenously with penicillin G, resulting in good improvement of the associated myopathy."	( Hagenah, R; Schneider, U; Wüllenweber, M, 1993)
"After treatment of neurosyphilis, steady improvements were noted in psychotic and cognitive symptoms."	( Ballas, C; Kohler, CG; Pickholtz, J, 2000)
"The present case suggests that neurosyphilis is an important differential diagnosis for presentations of unspecific oculomotor nerve palsy and that MPP therapy may prove an effective treatment for it, even where there has been the long clinical onset."	( Kowa, H; Kurihara, S; Mori, N; Nakashima, K; Yano, H, 2003)
"Success of neurosyphilis treatment is defined by normalization of cerebrospinal fluid (CSF) and clinical abnormalities."	( Lukehart, SA; Marra, CM; Maxwell, CL; Sahi, SK; Tantalo, LC, 2008)
"Appropriate treatment for neurosyphilis was instituted."	( Hong, YT; Kwon, OW; Song, JH, 2008)
"We diagnosed this case as Lissauer's general paresis and treated with intravenous benzylpenicillin potassium 24 million units per day for 2 weeks."	( Arahata, S; Araki, E; Fujii, N; Furuya, H; Syouzaki, T, 2010)
"Upon appropriate therapy for neurosyphilis, dramatic resolution of this brief episode ensued, prompting a literature review of psychosis associated with neurosyphilis."	( Abdul, J; Moolla, Y, 2016)
"A total of 123 neurosyphilis patients were recruited at baseline, 58 of these patients undergoing treatment, repeated CSF examinations and serological tests for syphilis at 6 months after treatment were included in the follow-up study."	( Chen, MJ; Gao, K; Li, SL; Lin, HL; Lin, LR; Lin, ZF; Liu, LL; Niu, JJ; Tong, ML; Xiao, Y; Yang, TC; Zhang, HL; Zheng, WH, 2017)
"He was treated for neurosyphilis at 44 years old in another hospital."	( Asano, A; Nishina, T; Satou, T; Uemori, M, 2018)
"Cerebral vasculitis caused by neurosyphilis is a re-emerging problem with diagnostic and treatment issues, especially for human immunodeficiency virus patients."	( Dion, J; Dupin, N; Le Jeunne, C; Mageau, A; Mouthon, L; Régent, A; Rodriguez-Régent, C, 2018)
"The ocular syphilis was treated as a neurosyphilis with 18 million units of penicillin per day, and the patient's vision eventually returned to 0."	( Hajjaj, A; Rothova, A; Saadulla, M; Steenmeijer, SR, 2018)
"The first-line treatment for neurosyphilis is aqueous crystalline penicillin."	( Buitrago-Garcia, D; Conterno, LO; Jimenez, A; Martí-Carvajal, AJ; Pardo, R, 2019)
"Data comparing neurosyphilis treatment regimens are limited."	( Dunaway, SB; Marra, CM; Maxwell, CL; Sahi, SK; Tantalo, LC, 2020)
"The protean manifestations of neurosyphilis make the recognition, diagnosis and early initiation of treatment challenging."	( Chu, M; Kumar, S; Sturm, J, 2021)
"Ocular syphilis is a form of neurosyphilis and requires neurosyphilis therapy regardless of when it develops after primary infection."	( Danaoui, K; El Fouar, H; Ihbibane, F; Tassi, N, 2022)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	231 (42.94)	23.3326
1990's	69 (12.83)	12.5806
2000's	82 (15.24)	18.1394
2010's	131 (24.35)	28.8240
2020's	25 (4.65)	9.53

Drug	Relationship Strength	Studies	Trials
5-hydroxytryptophan	low	1	0
quinacrine	low	2	0
bromide	low	1	0
carnitine	low	1	0
chlorine	low	2	0
salicylic acid	low	2	0
creatine	low	1	0
glycerol	low	2	0
iodine	low	6	0
niacin	low	1	0
nitrites	low	1	0
nitrous oxide	low	1	0
pyridoxine	low	1	0
thiamine	low	2	0
urea	low	1	0
1-anilino-8-naphthalenesulfonate	low	1	0
phenytoin	low	1	0
acetaminophen	low	2	0
acetarsol	low	2	0
theophylline	low	1	0
amitriptyline	low	1	0
amobarbital	low	1	0
aspirin	low	2	0
azathioprine	low	1	0
chlordiazepoxide	low	1	0
chlormezanone	low	1	0
chloroquine	low	2	0
chlorpromazine	low	4	0
diazepam	low	3	0
pentetic acid	low	3	0
valproic acid	low	3	0
doxepin	low	1	0
fluphenazine	low	1	0
foscarnet	low	1	0
furosemide	low	2	0
glutaral	low	1	0
haloperidol	low	3	0
hydroxychloroquine	low	1	0
ibuprofen	low	1	0
imipramine	low	1	0
2-propanol	low	3	0
lorazepam	low	1	0
edaravone	low	1	0
mephenytoin	low	1	0
methylphenidate	low	1	0
midazolam	low	1	0
pipamperone	low	1	0
piracetam	low	1	0
potassium iodide	low	3	0
probenecid	low	11	0
procaine	low	5	0
pyrimethamine	low	1	0
sulfanilamide	low	1	0
temazepam	low	1	0
prednisolone	low	12	0
reserpine	low	1	0
cephaloridine	low	2	0
thyroxine	low	1	0
dextroamphetamine	low	1	0
prednisone	low	8	0
penicillin g	medium	194	3
pilocarpine	low	3	0
chloramphenicol	low	7	0
cyanides	low	1	0
carbostyril	low	1	0
ampicillin	low	2	0
histidine	low	1	0
tryptophan	low	1	0
triamcinolone acetonide	low	2	0
methylprednisolone	low	3	0
phenothiazine	low	1	0
pyridostigmine bromide	low	1	0
benzathine	low	6	0
thiazoles	low	1	0
hydantoins	low	2	0
oxophenarsine	low	2	0
lithium carbonate	low	1	0
erythromycin	low	12	0
toluidine red	low	1	0
streptomycin	low	2	0
mercury	low	8	0
technetium	low	1	0
gadolinium	low	2	0
gold	low	5	0
zinc sulfate	low	2	0
galactose	low	2	0
trolamine salicylate	low	2	0
cephalexin	low	1	0
iodine	low	4	0
cephapirin	low	2	0
cetylpyridinium chloride anhydrous	low	1	0
fludrocortisone	low	1	0
4-methoxyamphetamine	low	3	0
transferrin	low	2	0
glutamic acid	low	1	0
amoxicillin	low	4	0
zidovudine	low	3	0
propiconazole	low	2	0
fomesafen	low	3	0
clopidogrel	low	1	0
aripiprazole	low	1	0
atorvastatin	low	1	0
lamivudine	low	1	0
penicillin v benzathine	low	1	0
cephalosporin c	medium	6	1
triazoles	low	2	0
1h-tetrazole	low	1	0
fluorodeoxyglucose f18	low	5	0
tetraconazole	low	1	0
clemizolpenicillin	low	1	0
n-acetyl-n-formyl-5-methoxykynurenamine	low	1	0
biotin	low	1	0
butyrylcarnitine	low	1	0
cortisone	low	6	0
trimethoprim, sulfamethoxazole drug combination	low	1	0
permanganate	low	1	0
inositol 3-phosphate	low	1	0
strychnine	low	1	0
abacavir	low	1	0
erythromycin estolate	low	1	0
cocaine	low	3	0
zithromax	low	3	0
arsphenamine	low	7	0
posaconazole	low	1	0
micafungin	low	1	0
potassium permanganate	low	1	0
17-ketosteroids	low	1	0
myelin basic protein	low	3	0
bilirubin	low	1	0
dinoprostone	low	1	0
linoleic acid	low	1	0
amphotericin b	low	2	0
levetiracetam	low	1	0
morphine	low	1	0
aluminum	low	1	0
bismuth	medium	32	1
arsenic	low	23	0
cysteine	low	3	0
heroin	low	1	0
cefotaxime	low	1	0
spirotrypan	low	1	0
gadolinium dtpa	low	4	0
palmitoylcarnitine	low	1	0
pituitrin	low	1	0
ants	low	1	0
phosphatidylcholines	low	26	0
tryparsamide	low	4	0
ro13-9904	medium	38	2
sodium ethylxanthate	medium	2	1
quetiapine fumarate	low	1	0
glycolipids	low	1	0
interleukin-8	low	2	0
technetium tc 99m gluceptate	low	1	0
tetracycline	low	16	0
chlortetracycline	low	9	0
oxytetracycline, anhydrous	low	5	0
minocycline	low	1	0
rolitetracycline	low	1	0
dolutegravir	low	1	0
transforming growth factor beta	low	1	0
agar	low	1	0
vitamin b 12	low	1	0
exudates	low	1	0
clozapine	low	2	0
olanzapine	low	3	0
sildenafil citrate	low	1	0
eye	low	22	0
ego	low	1	0
technetium tc 99m bicisate	low	3	0

Protein Targets (1,283)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain B, pheromone binding protein	0	0	1	1
Chain A, pheromone binding protein	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	9	0	0	9
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
acid sphingomyelinase	3	0	0	3
thioredoxin reductase	27	0	0	27
USP1 protein, partial	22	0	0	22
TDP1 protein	42	0	0	42
vitamin D3 receptor isoform VDRA	18	0	0	18
importin subunit beta-1 isoform 1	6	0	0	6
flap endonuclease 1	13	0	0	13
serine/threonine-protein kinase PLK1	5	0	0	5
snurportin-1	6	0	0	6
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	10	0	0	10
GTP-binding nuclear protein Ran isoform 1	3	0	0	3
DNA polymerase eta isoform 1	6	0	0	6
DNA polymerase iota isoform a (long)	20	0	0	20
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
geminin	39	0	0	39
DNA polymerase kappa isoform 1	14	0	0	14
fibroblast growth factor 22 isoform 1 precursor	0	0	0	1
Mitogen-activated protein kinase 13	0	1	0	1
Beta-lactamase	0	1	0	1
Transthyretin	0	1	1	3
Fatty acid-binding protein, intestinal	0	2	1	3
Fatty acid-binding protein, adipocyte	0	3	1	4
Cyclin-A2	0	1	0	1
Cannabinoid receptor 1	0	0	1	1
Cyclin-dependent kinase 2	0	1	1	2
Choline O-acetyltransferase	0	1	0	1
Mitogen-activated protein kinase 12	0	1	0	1
Guanine nucleotide-binding protein G	5	0	0	5
Fatty acid-binding protein 5	0	1	1	2
Fatty acid-binding protein 5	0	0	1	1
Mitogen-activated protein kinase 11	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
hypoxia-inducible factor 1 alpha subunit	15	0	0	15
RAR-related orphan receptor gamma	37	0	0	37
GLI family zinc finger 3	43	0	0	43
AR protein	55	0	0	55
aldehyde dehydrogenase 1 family, member A1	25	0	0	25
retinoic acid nuclear receptor alpha variant 1	46	0	0	46
retinoid X nuclear receptor alpha	30	0	0	30
estrogen nuclear receptor alpha	62	0	0	62
peroxisome proliferator-activated receptor delta	29	0	0	29
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	30	0	0	30
activating transcription factor 6	14	0	0	14
v-jun sarcoma virus 17 oncogene homolog (avian)	23	0	0	23
Histone H2A.x	14	0	0	14
thyroid hormone receptor beta isoform a	12	0	0	12
heat shock protein beta-1	14	0	0	14
nuclear factor erythroid 2-related factor 2 isoform 1	48	0	0	48
lamin isoform A-delta10	35	0	0	35
Voltage-dependent calcium channel gamma-2 subunit	20	0	0	20
Glutamate receptor 2	20	2	1	23
5-hydroxytryptamine receptor 2C	0	18	2	20
5-hydroxytryptamine receptor 2A	0	18	2	20
5-hydroxytryptamine receptor 1A	0	24	3	27
5-hydroxytryptamine receptor 1B	0	16	2	18
5-hydroxytryptamine receptor 1D	0	8	2	10
5-hydroxytryptamine receptor 1F	0	8	2	10
5-hydroxytryptamine receptor 2B	0	17	3	20
5-hydroxytryptamine receptor 6	0	4	2	6
Sodium-dependent serotonin transporter	0	29	2	31
Sodium-dependent serotonin transporter	0	8	1	10
5-hydroxytryptamine receptor 7	0	9	2	11
5-hydroxytryptamine receptor 5A	0	4	2	6
5-hydroxytryptamine receptor 5B	0	4	2	6
5-hydroxytryptamine receptor 3A	0	5	2	7
5-hydroxytryptamine receptor 4	0	4	2	6
5-hydroxytryptamine receptor 3B	0	5	2	7
Luciferase	10	0	0	10
cytochrome P450 family 3 subfamily A polypeptide 4	25	0	0	25
cytochrome P450 2D6	17	0	0	17
euchromatic histone-lysine N-methyltransferase 2	36	0	0	36
peripheral myelin protein 22	22	0	0	22
Albumin	0	3	9	13
ATP-dependent translocase ABCB1	0	15	1	22
Replicase polyprotein 1ab	0	6	4	10
Replicase polyprotein 1ab	0	7	4	11
Reverse transcriptase/RNaseH	0	4	5	12
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	8	0	8
ATAD5 protein, partial	11	0	0	11
GLS protein	20	0	0	20
Microtubule-associated protein tau	18	0	0	18
Smad3	4	0	0	4
thyroid stimulating hormone receptor	19	0	0	19
nuclear receptor subfamily 1, group I, member 3	29	0	0	29
progesterone receptor	25	0	0	25
EWS/FLI fusion protein	23	0	0	23
estrogen-related nuclear receptor alpha	46	0	0	46
peroxisome proliferator activated receptor gamma	31	0	0	31
aryl hydrocarbon receptor	20	0	0	20
chromobox protein homolog 1	22	0	0	22
thyroid hormone receptor beta isoform 2	41	0	0	41
cytochrome P450 3A4 isoform 1	16	0	0	16
Gamma-aminobutyric acid receptor subunit pi	16	7	1	24
ATP-binding cassette sub-family C member 3	0	37	0	37
Multidrug resistance-associated protein 4	0	37	0	38
Solute carrier family 22 member 6	0	11	0	12
Carbonic anhydrase 12	0	6	0	11
UDP-glucuronosyltransferase 1A9	0	2	0	7
Bile salt export pump	0	15	0	15
Bile salt export pump	0	58	0	58
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	18	0	27
Carbonic anhydrase 2	0	19	1	29
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	0	1	2
Cytochrome P450 1A2	0	4	1	7
Prostaglandin G/H synthase 1	0	5	0	5
Carbonic anhydrase 3	0	5	0	9
Cytochrome P450 3A4	0	17	2	22
Cytochrome P450 2D6	0	6	1	8
Cytochrome P450 2C9	0	20	1	22
Polyunsaturated fatty acid lipoxygenase ALOX15	0	4	0	4
Gamma-aminobutyric acid receptor subunit beta-1	16	7	1	24
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	16	7	1	24
Gamma-aminobutyric acid receptor subunit gamma-2	16	7	1	24
UDP-glucuronosyltransferase 1-6	0	2	0	5
Gamma-aminobutyric acid receptor subunit alpha-5	16	7	1	24
Gamma-aminobutyric acid receptor subunit alpha-3	16	7	1	24
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	4	0	7
Carbonic anhydrase 4	0	12	0	17
Prostaglandin G/H synthase 1	0	7	0	7
Carbonic anhydrase 6	0	7	0	12
Gamma-aminobutyric acid receptor subunit gamma-1	16	7	1	24
Gamma-aminobutyric acid receptor subunit alpha-2	16	7	1	24
Gamma-aminobutyric acid receptor subunit alpha-4	16	7	1	24
Gamma-aminobutyric acid receptor subunit gamma-3	16	7	1	24
Gamma-aminobutyric acid receptor subunit alpha-6	16	7	1	24
Carbonic anhydrase 5A, mitochondrial	0	8	0	14
Prostaglandin G/H synthase 2	0	7	0	8
Carbonic anhydrase 7	0	5	0	10
Nuclear receptor ROR-gamma	12	0	0	12
Cytochrome P450 2J2	0	13	0	14
Gamma-aminobutyric acid receptor subunit alpha-1	16	8	1	25
Gamma-aminobutyric acid receptor subunit beta-3	16	7	1	24
Gamma-aminobutyric acid receptor subunit beta-2	16	7	1	24
Carbonic anhydrase 9	0	9	0	14
GABA theta subunit	16	7	1	24
Canalicular multispecific organic anion transporter 1	0	38	0	38
Carbonic anhydrase 15	0	8	0	11
Carbonic anhydrase 13	0	4	0	9
Gamma-aminobutyric acid receptor subunit epsilon	16	7	1	24
Carbonic anhydrase 14	0	5	0	10
Carbonic anhydrase 5B, mitochondrial	0	5	0	11
toxin B	0	0	0	1
thioredoxin glutathione reductase	5	0	0	5
DNA polymerase beta	7	0	0	7
eyes absent homolog 2 isoform a	1	0	0	1
survival motor neuron protein isoform d	11	0	0	11
muscleblind-like protein 1 isoform 1	8	0	0	8
14 kDa phosphohistidine phosphatase	0	1	0	1
ATP-dependent phosphofructokinase	15	0	0	15
Chain A, HADH2 protein	10	0	0	10
Chain B, HADH2 protein	10	0	0	10
NFKB1 protein, partial	6	0	0	6
arylsulfatase A	14	0	0	14
cytochrome P450 2D6 isoform 1	10	0	0	10
D(1A) dopamine receptor	7	0	0	7
atrial natriuretic peptide receptor 2 precursor	4	0	0	4
serine/threonine-protein kinase mTOR isoform 1	8	0	0	8
muscarinic acetylcholine receptor M1	13	0	0	13
Solute carrier family 22 member 1	0	11	0	14
Polyunsaturated fatty acid lipoxygenase ALOX15B	8	0	0	8
Voltage-dependent L-type calcium channel subunit alpha-1F	0	11	0	11
5-hydroxytryptamine receptor 4	0	18	0	18
Albumin	0	0	8	8
High affinity nerve growth factor receptor	0	1	2	3
Aldo-keto reductase family 1 member B1	0	17	0	17
Muscarinic acetylcholine receptor M2	0	20	2	22
Muscarinic acetylcholine receptor M4	0	18	1	19
Muscarinic acetylcholine receptor M1	0	11	0	12
Muscarinic acetylcholine receptor M3	0	10	0	11
Muscarinic acetylcholine receptor M4	0	10	0	11
Muscarinic acetylcholine receptor M5	0	11	0	12
Muscarinic acetylcholine receptor M5	0	18	0	18
Alpha-2A adrenergic receptor	0	20	1	21
Muscarinic acetylcholine receptor M2	0	10	0	11
Muscarinic acetylcholine receptor M1	0	19	4	23
Angiotensin-converting enzyme	0	12	0	12
D(2) dopamine receptor	0	18	2	26
Alpha-2B adrenergic receptor	0	20	0	20
Alpha-2C adrenergic receptor	0	21	0	21
Muscarinic acetylcholine receptor M3	0	20	1	21
D(1A) dopamine receptor	0	17	0	20
D(1B) dopamine receptor	0	7	0	10
UDP-glucuronosyltransferase 1A4	0	1	0	7
Sodium-dependent noradrenaline transporter	0	25	1	26
Histamine H2 receptor	0	17	2	19
Alpha-1D adrenergic receptor	0	21	0	21
5-hydroxytryptamine receptor 2A	0	23	0	25
5-hydroxytryptamine receptor 2C	0	21	1	22
Histamine H1 receptor	0	9	1	10
Histamine H1 receptor	0	24	5	31
D(3) dopamine receptor	0	19	2	26
Sodium channel protein type 1 subunit alpha	0	5	0	5
Sodium channel protein type 4 subunit alpha	0	6	0	8
UDP-glucuronosyltransferase 1A3	0	0	0	4
5-hydroxytryptamine receptor 2B	0	17	1	18
Alpha-1A adrenergic receptor	0	18	1	19
Histamine H2 receptor	10	3	1	17
D(1A) dopamine receptor	6	1	0	7
5-hydroxytryptamine receptor 6	0	16	0	17
5-hydroxytryptamine receptor 7	0	7	0	7
Voltage-dependent N-type calcium channel subunit alpha-1B	0	2	0	2
Sodium channel protein type 7 subunit alpha	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1D	0	11	0	11
Sodium-dependent dopamine transporter	0	16	1	17
Potassium voltage-gated channel subfamily H member 2	0	27	0	27
Voltage-dependent L-type calcium channel subunit alpha-1S	0	11	0	11
Voltage-dependent L-type calcium channel subunit alpha-1C	0	11	0	11
Sodium channel protein type 5 subunit alpha	0	6	0	6
Sodium channel protein type 9 subunit alpha	0	7	0	7
Sigma non-opioid intracellular receptor 1	0	6	1	7
Nuclear receptor subfamily 3 group C member 3	0	11	0	11
Sodium channel protein type 2 subunit alpha	0	5	0	5
Ataxin-2	23	0	0	23
Sigma non-opioid intracellular receptor 1	0	18	1	19
Sodium channel protein type 3 subunit alpha	0	5	0	5
Sodium channel protein type 11 subunit alpha	0	4	0	4
Sodium channel protein type 8 subunit alpha	0	4	0	4
Histamine H3 receptor	0	8	2	10
Sodium channel protein type 10 subunit alpha	0	4	0	4
farnesoid X nuclear receptor	22	0	0	22
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	17	0	0	17
Chain A, Beta-lactamase	11	0	0	11
Chain A, 2-oxoglutarate Oxygenase	11	0	0	11
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	4
apical membrane antigen 1, AMA1	7	0	0	7
Beta-lactamase	0	0	0	4
Beta-lactamase SHV-1	0	0	0	3
Beta-lactamase SHV-1	0	0	0	4
Beta-lactamase	0	0	0	4
Kappa-type opioid receptor	0	3	0	6
Solute carrier family 15 member 1	0	9	0	9
Solute carrier family 15 member 1	0	3	0	3
B2 metallo-beta-lactamase	0	0	0	5
Solute carrier family 15 member 2	0	6	0	6
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	3
Solute carrier family 15 member 2	0	7	0	8
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	3
Chain A, Cruzipain	6	0	0	6
interleukin 8	9	0	0	9
phosphopantetheinyl transferase	14	0	0	14
glucocorticoid receptor [Homo sapiens]	42	0	0	42
vitamin D (1,25- dihydroxyvitamin D3) receptor	27	0	0	27
tumor necrosis factor	1	0	0	1
Cytochrome P450 2C19	0	4	0	6
Aurora kinase B	0	1	0	1
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
Beta-lactamase	0	0	0	3
Beta-lactamase	0	1	0	4
Beta-lactamase	0	0	0	3
Metallo-beta-lactamase type 2	0	0	0	3
Metallo-beta-lactamase VIM-11	0	0	0	3
Metallo-beta-lactamase VIM-2	0	0	0	3
Beta-lactamase	0	0	0	3
Metallo-beta-lactamase	0	0	0	3
Beta-lactamase	0	1	0	4
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	8	0	0	8
60 kDa heat shock protein, mitochondrial	0	3	0	3
Beta-lactamase OXA-7	0	0	0	1
Spike glycoprotein	21	3	4	28
10 kDa heat shock protein, mitochondrial	0	3	0	3
Angiopoietin-1 receptor	0	0	1	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Thiosulfate sulfurtransferase	0	3	0	3
Metallo-beta-lactamase VIM-13	0	0	0	3
Efflux transporter	0	0	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase Toho-1	0	0	0	4
Beta-lactamase	0	0	0	3
Class D beta-lactamase	0	0	0	2
60 kDa chaperonin	0	3	0	3
Metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
10 kDa chaperonin	0	3	0	3
Metallo-b-lactamase	0	0	0	4
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	4
Histamine H3 receptor	0	1	0	4
Beta-lactamase class B VIM-2	0	0	0	4
Beta-lactamase VIM-1	0	0	0	3
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	19	0	0	19
5-hydroxytryptamine receptor 3E	0	3	0	3
acetylcholinesterase	16	0	0	16
SMAD family member 2	15	0	0	15
Fumarate hydratase	10	0	0	10
PPM1D protein	5	0	0	5
SMAD family member 3	15	0	0	15
estrogen receptor 2 (ER beta)	18	0	0	18
pregnane X nuclear receptor	39	0	0	39
G	14	0	0	14
polyprotein	10	0	0	10
67.9K protein	6	0	0	6
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	4	0	0	4
thyroid stimulating hormone receptor	17	0	0	17
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	12	0	0	12
lysosomal alpha-glucosidase preproprotein	6	0	0	6
mu-type opioid receptor isoform MOR-1	0	0	1	1
nuclear factor erythroid 2-related factor 2 isoform 2	8	0	0	8
potassium voltage-gated channel subfamily H member 2 isoform d	20	0	0	20
transcriptional regulator ERG isoform 3	6	0	0	6
nuclear receptor ROR-gamma isoform 1	13	0	0	13
histone acetyltransferase KAT2A isoform 1	10	0	0	10
5-hydroxytryptamine receptor 2A	0	0	1	1
neuropeptide S receptor isoform A	2	0	0	2
Solute carrier family 22 member 2	0	4	0	7
5-hydroxytryptamine receptor 3A	0	2	0	2
5-hydroxytryptamine receptor 3B	0	3	0	3
Interferon beta	21	0	0	21
HLA class I histocompatibility antigen, B alpha chain	14	0	0	14
Cellular tumor antigen p53	34	0	0	34
5-hydroxytryptamine receptor 1A	0	10	4	14
Neuronal acetylcholine receptor subunit alpha-4	3	2	0	5
Neuronal acetylcholine receptor subunit beta-2	3	2	0	5
Alpha-1B adrenergic receptor	0	16	1	17
D	0	11	0	11
D(4) dopamine receptor	0	12	1	18
Alpha-1D adrenergic receptor	0	12	1	13
D(4) dopamine receptor	0	9	0	9
Histamine H1 receptor	0	6	3	10
5-hydroxytryptamine receptor 7	0	7	0	7
Alpha-1A adrenergic receptor	0	7	0	7
Alpha-1B adrenergic receptor	0	5	0	5
5-hydroxytryptamine receptor 3A	0	3	0	3
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	5	0	5
D(2) dopamine receptor	0	13	0	14
Inositol monophosphatase 1	8	0	0	8
5-hydroxytryptamine receptor 3D	0	3	0	3
Multidrug and toxin extrusion protein 2	0	3	0	3
5-hydroxytryptamine receptor 3C	0	3	0	3
Inositol hexakisphosphate kinase 1	14	0	0	14
Multidrug and toxin extrusion protein 1	0	7	0	7
cytochrome P450 2C9, partial	14	0	0	14
Chain A, Phospholipase A2 isoform 3	0	0	1	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
hypothetical protein, conserved	1	0	0	1
glucocerebrosidase	5	0	0	5
Rac1 protein	0	0	1	1
IDH1	15	0	0	15
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
Bloom syndrome protein isoform 1	8	0	0	8
lethal factor (plasmid)	11	0	0	11
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin G/H synthase 1	0	3	0	3
Prostaglandin G/H synthase 2	0	2	0	2
Epidermal growth factor receptor	0	4	0	4
Fatty acid-binding protein, liver	0	5	0	5
Integrin beta-3	3	1	1	5
Myeloperoxidase	0	2	0	2
Seed linoleate 13S-lipoxygenase-1	0	2	0	2
Integrin alpha-IIb	3	1	1	5
Glutathione hydrolase 1 proenzyme	0	1	0	1
Adenosine receptor A1	0	8	0	11
Adenosine receptor A2a	0	3	0	7
Substance-P receptor	0	3	0	3
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	2	0	2
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	4	0	4
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	2	0	2
Solute carrier family 22 member 20	0	5	0	5
Solute carrier family 22 member 6	0	5	0	5
Sigma non-opioid intracellular receptor 1	0	4	2	6
caspase 7, apoptosis-related cysteine protease	13	0	0	13
caspase-3	13	0	0	13
Caspase-7	5	0	0	5
caspase-3	5	0	0	5
Solute carrier organic anion transporter family member 2B1	0	0	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
Insulin receptor	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Histone deacetylase 1	0	3	0	3
Histone deacetylase 2	0	3	0	3
Solute carrier organic anion transporter family member 1B3	0	5	0	7
Histone deacetylase 6	0	3	0	3
Solute carrier organic anion transporter family member 1B1	0	6	0	9
Chain A, Ferritin light chain	3	0	0	3
P53	1	0	0	1
peripheral myelin protein 22 isoform 1	10	0	0	10
hemoglobin subunit beta	2	0	0	2
cellular tumor antigen p53 isoform a	4	0	0	4
M-phase phosphoprotein 8	12	0	0	12
ATPase family AAA domain-containing protein 5	16	0	0	16
Protein-arginine deiminase type-4	0	9	0	9
Chain A, Putative fructose-1,6-bisphosphate aldolase	7	0	0	7
caspase-1 isoform alpha precursor	2	0	0	2
Caspase-7	2	0	0	2
Chain A, Avidin	0	0	1	1
Chain A, Protein (streptavidin)	0	0	1	1
Chain B, Protein (streptavidin)	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin Complex With Biotin	0	0	1	1
Chain D, Circularly Permuted Core-streptavidin E51/a46	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
nonstructural protein 1	0	1	0	1
green fluorescent protein, partial	0	1	0	1
insulin-degrading enzyme isoform 1	0	0	1	1
Streptavidin	0	0	1	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
Carbonic anhydrase	0	6	0	9
mitogen-activated protein kinase 1	11	0	0	11
Vpr	1	0	0	1
Major prion protein	0	0	6	6
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	3	0	9
Cytochrome P450 2B6	0	1	1	2
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	1	0	1
Chain A, serum paraoxonase	0	1	0	1
Neutrophil cytosol factor 1	0	1	0	1
Carbonic anhydrase 13	0	2	0	4
Poly [ADP-ribose] polymerase tankyrase-2	0	1	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 5	0	1	0	2
Solute carrier family 22 member 16	0	0	0	1
Solute carrier family 22 member 21	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase VIM-19	0	0	0	2
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	3
Metallo-beta-lactamase VIM-2	0	0	0	2
Solute carrier family 22 member 6	0	7	0	9
Solute carrier family 22 member 7	0	3	0	6
BlaVIM-1	0	0	0	2
Beta-lactamase	0	0	0	3
Solute carrier family 22 member 8	0	7	0	10
Beta-lactamase	0	0	0	3
Solute carrier family 22 member 11	0	4	0	7
Solute carrier family 22 member 8	0	6	0	7
Solute carrier family 22 member 7	0	4	0	7
bromodomain adjacent to zinc finger domain 2B	10	0	0	10
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	3	3
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase OXA-10	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase TEM	0	1	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase IMP-1	0	0	0	2
Beta-lactamase	0	0	0	2
thyrotropin-releasing hormone receptor	3	0	0	3
Caspase-2	0	0	1	1
streptokinase A precursor	0	0	5	5
Dihydroxyacetone phosphate acyltransferase	0	0	0	2
30S ribosomal protein S6	0	4	1	5
30S ribosomal protein S7	0	4	1	5
50S ribosomal protein L15	0	4	1	5
50S ribosomal protein L10	0	4	1	5
50S ribosomal protein L11	0	4	1	5
50S ribosomal protein L7/L12	0	4	1	5
50S ribosomal protein L19	0	4	1	5
50S ribosomal protein L1	0	4	1	5
50S ribosomal protein L20	0	4	1	5
50S ribosomal protein L27	0	4	1	5
50S ribosomal protein L28	0	4	1	5
50S ribosomal protein L29	0	4	1	5
50S ribosomal protein L31	0	4	1	5
50S ribosomal protein L31 type B	0	4	1	5
50S ribosomal protein L32	0	4	1	5
50S ribosomal protein L33	0	4	1	5
50S ribosomal protein L34	0	4	1	5
50S ribosomal protein L35	0	4	1	5
50S ribosomal protein L36	0	4	1	5
30S ribosomal protein S10	0	4	1	5
30S ribosomal protein S11	0	4	1	5
30S ribosomal protein S12	0	4	1	5
30S ribosomal protein S13	0	4	1	5
30S ribosomal protein S16	0	4	1	5
30S ribosomal protein S18	0	4	1	5
30S ribosomal protein S19	0	4	1	5
30S ribosomal protein S20	0	4	1	5
30S ribosomal protein S2	0	4	1	5
30S ribosomal protein S3	0	4	1	5
30S ribosomal protein S4	0	4	1	5
30S ribosomal protein S5	0	4	1	5
30S ribosomal protein S8	0	4	1	5
30S ribosomal protein S9	0	4	1	5
50S ribosomal protein L13	0	4	1	5
50S ribosomal protein L14	0	4	1	5
50S ribosomal protein L16	0	4	1	5
50S ribosomal protein L23	0	4	1	5
30S ribosomal protein S15	0	4	1	5
50S ribosomal protein L17	0	4	1	5
50S ribosomal protein L21	0	4	1	5
50S ribosomal protein L30	0	4	1	5
50S ribosomal protein L6	0	4	1	5
30S ribosomal protein S14	0	4	1	5
30S ribosomal protein S17	0	4	1	5
30S ribosomal protein S1	0	4	1	5
50S ribosomal protein L18	0	4	1	5
50S ribosomal protein L2	0	4	1	5
50S ribosomal protein L3	0	4	1	5
50S ribosomal protein L24	0	4	1	5
50S ribosomal protein L4	0	4	1	5
50S ribosomal protein L22	0	4	1	5
50S ribosomal protein L5	0	4	1	5
30S ribosomal protein S21	0	4	1	5
50S ribosomal protein L25	0	4	1	5
50S ribosomal protein L36 2	0	4	1	5
Methionine--tRNA ligase, mitochondrial	0	0	1	1
glp-1 receptor, partial	9	0	0	9
Gamma-aminobutyric acid receptor subunit alpha-1	0	4	0	4
Gamma-aminobutyric acid receptor subunit beta-1	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-2	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-3	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-1	0	8	2	10
Translocator protein	0	3	2	6
Gamma-aminobutyric acid receptor subunit gamma-2	0	8	1	9
Gamma-aminobutyric acid receptor subunit alpha-4	0	4	0	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	4	0	4
Gamma-aminobutyric acid receptor subunit beta-3	0	8	1	9
Cholecystokinin receptor type A	0	3	0	3
Gastrin/cholecystokinin type B receptor	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-5	0	8	2	10
Gamma-aminobutyric acid receptor subunit alpha-3	0	8	1	9
Gamma-aminobutyric acid receptor subunit alpha-2	0	8	1	9
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
Spike glycoprotein	0	3	4	7
Replicase polyprotein 1ab	0	3	4	7
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
Transmembrane protease serine 2	0	3	4	7
Dihydrofolate reductase	0	3	0	3
DNA ligase	0	1	0	1
Riboflavin-binding protein	0	1	2	3
Amyloid-beta precursor protein	0	6	0	7
Histidine-rich protein PFHRP-II	0	2	0	3
Procathepsin L	0	3	4	7
Replicase polyprotein 1a	0	3	4	7
Replicase polyprotein 1ab	0	3	4	7
Spike glycoprotein	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
DNA ligase 1	0	1	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	2	2
Beta-secretase 1	0	2	0	2
Calcium-dependent protein kinase 1	0	0	1	1
MO15-related protein kinase Pfmrk	0	1	0	1
DNA ligase A	0	1	0	1
Sigma intracellular receptor 2	0	4	0	4
Phosphoethanolamine N-methyltransferase	0	2	0	2
Angiotensin-converting enzyme 2	0	3	4	7
Cysteine proteinase falcipain 2a	0	1	0	1
Cysteine proteinase falcipain 2a	0	1	0	1
Proteasome subunit beta type-11	0	0	0	1
Thrombopoietin	4	0	0	4
NADPH oxidase 1	0	3	0	3
Snq2p	0	0	0	4
Adenylate cyclase type 1	0	4	0	4
histone deacetylase 9 isoform 3	2	0	0	2
ras-related protein Rab-9A	3	0	0	3
Proteasome subunit alpha type-7	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	3	0	3
Transient receptor potential cation channel subfamily V member 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	3	0	3
Potassium channel subfamily K member 2	0	3	2	5
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	2	0	2
Major prion protein	0	1	1	2
Tyrosine-protein kinase Fyn	0	2	0	2
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	3	1	4
Sphingomyelin phosphodiesterase	0	2	0	2
D(3) dopamine receptor	0	10	0	10
Alpha-2B adrenergic receptor	0	10	1	11
D(2) dopamine receptor	0	5	0	5
Proteasome subunit beta type-1	0	0	0	1
Substance-K receptor	0	4	0	4
Adenylate cyclase type 3	0	4	0	4
Alpha-2C adrenergic receptor	0	10	1	11
Alpha-2A adrenergic receptor	0	10	1	11
Sodium-dependent dopamine transporter	0	10	1	11
D(1B) dopamine receptor	0	7	0	7
Proteasome subunit alpha type-1	0	0	0	1
Proteasome subunit alpha type-2	0	0	0	1
Proteasome subunit alpha type-3	0	0	0	1
Proteasome subunit alpha type-4	0	0	0	1
Adenylate cyclase type 2	0	4	0	4
Adenylate cyclase type 4	0	4	0	4
Proteasome subunit beta type-8	0	0	0	1
Proteasome subunit beta type-9	0	0	0	1
Proteasome subunit alpha type-5	0	0	0	1
Proteasome subunit beta type-4	0	0	0	1
Proteasome subunit beta type-6	0	0	0	1
Proteasome subunit beta type-5	0	0	0	1
Trypanothione reductase	0	6	0	6
Melanocortin receptor 4	0	2	0	2
Melanocortin receptor 5	0	4	0	4
Pleiotropic ABC efflux transporter of multiple drugs	0	4	0	8
Mu-type opioid receptor	0	10	2	13
Glutamate receptor ionotropic, NMDA 1	0	8	1	12
Adenylate cyclase type 8	0	4	0	4
Proteasome subunit beta type-10	0	0	0	1
Delta-type opioid receptor	0	6	1	8
Kappa-type opioid receptor	0	6	1	8
Melanocortin receptor 3	0	2	0	2
Proteasome subunit beta type-3	0	0	0	1
Proteasome subunit beta type-2	0	0	0	1
Gastrin/cholecystokinin type B receptor	0	3	0	3
Proteasome subunit alpha type-6	0	0	1	2
Calmodulin	0	1	2	3
Aldehyde oxidase 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	8	1	12
Glutamate receptor ionotropic, NMDA 2B	0	8	1	12
Glutamate receptor ionotropic, NMDA 2C	0	8	1	12
Adenylate cyclase type 6	0	4	0	4
Adenylate cyclase type 5	0	4	0	4
Glutamate receptor ionotropic, NMDA 1	0	4	0	4
Aldehyde oxidase	0	3	0	3
Glutamate receptor ionotropic, NMDA 2A	0	4	0	4
Glutamate receptor ionotropic, NMDA 2B	0	4	0	4
Glutamate receptor ionotropic, NMDA 2C	0	3	0	3
Glutamate receptor ionotropic, NMDA 2D	0	8	1	12
Adenylyl cyclase 7	0	4	0	4
Proteasome subunit alpha-type 8	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	3	0	3
Glutamate receptor ionotropic, NMDA 3B	0	8	1	12
D	0	4	0	4
Proteasome subunit beta type-7	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	8	1	12
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	4	0	4
P2Y purinoceptor 12	0	3	0	3
Gamma-aminobutyric acid receptor subunit pi	0	7	0	7
Gamma-aminobutyric acid receptor subunit delta	0	7	0	7
Gamma-aminobutyric acid receptor subunit beta-1	0	7	0	7
Translocator protein	0	2	0	2
Translocator protein	0	4	0	4
Gamma-aminobutyric acid receptor subunit beta-2	0	7	1	8
Gamma-aminobutyric acid receptor subunit alpha-4	0	7	0	7
Gamma-aminobutyric acid receptor subunit epsilon	0	7	0	7
Gamma-aminobutyric acid receptor subunit alpha-6	0	7	0	7
Gamma-aminobutyric acid receptor subunit gamma-1	0	7	0	7
Gamma-aminobutyric acid receptor subunit gamma-3	0	7	0	7
Gamma-aminobutyric acid receptor subunit theta	0	7	0	7
nonstructural protein 1	7	0	0	7
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	4	0	0	4
Cytochrome P450 2C8	0	2	0	2
Liver carboxylesterase 1	0	2	0	5
Rap guanine nucleotide exchange factor 4	1	0	0	1
Beta-1 adrenergic receptor	0	1	0	1
cytochrome P450 2C19 precursor	5	0	0	5
cytochrome P450 2C9 precursor	4	0	0	4
short transient receptor potential channel 6 isoform 1	0	0	1	1
transient receptor potential cation channel subfamily V member 1	2	0	0	2
Beta-2 adrenergic receptor	0	4	0	4
Beta-1 adrenergic receptor	0	3	0	3
Endothelin receptor type B	0	1	0	1
5-hydroxytryptamine receptor 3A	0	2	0	2
Endothelin receptor type B	0	1	0	1
Beta-3 adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 2C	0	4	0	4
5-hydroxytryptamine receptor 2A	0	3	0	3
5-hydroxytryptamine receptor 5A	0	1	0	1
D(2) dopamine receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
D(2) dopamine receptor	0	3	0	3
5-hydroxytryptamine receptor 2B	0	3	0	3
5-hydroxytryptamine receptor 4	0	2	0	2
Transporter	0	4	0	4
Cholecystokinin receptor type A	0	2	0	2
5-hydroxytryptamine receptor 1A	0	2	0	2
Histamine H4 receptor	0	2	3	5
Transporter	0	7	0	7
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Fatty acid-binding protein, heart	0	3	0	3
Muscarinic acetylcholine receptor M2	0	1	0	1
Tryptophan 5-hydroxylase 1	0	1	0	1
Lysosomal Pro-X carboxypeptidase	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	4	0	4
Leukotriene B4 receptor 1	0	1	0	1
Sodium-dependent dopamine transporter	0	3	0	3
Leukotriene B4 receptor 2	0	1	0	1
endonuclease IV	5	0	0	5
dopamine D1 receptor	2	0	0	2
pregnane X receptor	7	0	0	7
regulator of G-protein signaling 4	12	0	0	12
atrial natriuretic peptide receptor 1 precursor	3	0	0	3
Glucocorticoid receptor	0	10	2	17
Sex hormone-binding globulin	0	0	1	1
Glycine receptor subunit alpha-1	0	11	0	11
Corticosteroid-binding globulin	0	2	0	2
Glycine receptor subunit beta	0	10	0	10
Glycine receptor subunit alpha-2	0	10	0	10
Glycine receptor subunit alpha-3	0	10	0	10
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
TAR DNA-binding protein 43	8	0	0	8
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Proton-coupled amino acid transporter 1	0	1	0	1
Phenylethanolamine N-methyltransferase	0	1	0	1
Amine oxidase [flavin-containing] B	0	2	0	2
Amine oxidase [flavin-containing] A	0	4	0	4
Amine oxidase [flavin-containing] B	0	3	0	3
Amine oxidase [flavin-containing] B	0	1	0	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Gamma-aminobutyric acid	0	2	0	2
Alpha-1-acid glycoprotein 1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	0	2
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Sphingosine-1-phosphate lyase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
prostaglandin E2 receptor EP2 subtype	1	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	2	1	3
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin F2-alpha receptor	0	0	1	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP3 subtype	0	2	1	3
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Prostacyclin receptor	0	2	1	3
Solute carrier organic anion transporter family member 2A1	0	1	0	2
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 7	0	0	0	1
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Chain A, PFV integrase	0	1	0	1
Chain A, PFV integrase	0	1	0	1
Chain A, PFV integrase	0	1	0	1
Cytochrome P450 2A6	0	3	1	4
Integrase	0	0	1	1
Sigma intracellular receptor 2	0	3	0	3
Vesicular acetylcholine transporter	0	2	0	2
Integrase	0	3	1	4
Acetylcholinesterase	0	4	0	4
cGMP-specific 3',5'-cyclic phosphodiesterase	0	2	0	2
Acetylcholinesterase	0	1	0	1
Cholinesterase	0	4	0	4
Amine oxidase [flavin-containing] A	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	8	2	11
Acetylcholinesterase	0	2	0	2
Choline O-acetyltransferase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Glycogen synthase kinase-3 beta	0	2	0	2
Cholinesterase	0	4	0	4
Cholinesterase	0	1	0	1
Acetylcholine receptor subunit epsilon	0	1	0	1
Cytochrome P450 1B1	0	2	0	2
Acyl-CoA:cholesterol acyltransferase	0	1	0	1
Carboxylic ester hydrolase	0	1	0	2
Carboxylic ester hydrolase	0	2	0	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
UDP-glucuronosyltransferase 2B17	0	0	0	1
UDP-glucuronosyltransferase 1A7	0	1	0	2
Motilin receptor	0	0	1	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	2	0	2
Motilin receptor	0	1	1	2
Rap guanine nucleotide exchange factor 3	4	0	0	4
ATP-dependent translocase ABCB1	0	5	0	5
60 kDa chaperonin	0	2	0	2
Chitinase B	0	1	0	1
ATP-dependent translocase ABCB1	0	5	0	5
Low molecular weight phosphotyrosine protein phosphatase	0	2	0	2
Lanosterol 14-alpha demethylase	0	2	0	2
GALC protein	4	0	0	4
nuclear receptor subfamily 1, group I, member 2	7	0	0	7
ubiquitin carboxyl-terminal hydrolase 2 isoform a	6	0	0	6
Adenosine receptor A3	0	5	0	5
Beta-3 adrenergic receptor	0	2	0	2
Androgen receptor	0	4	0	4
Disintegrin and metalloproteinase domain-containing protein 17	4	0	0	4
Chain A, probable fosfomycin resistance protein	0	0	1	1
Chain B, probable fosfomycin resistance protein	0	0	1	1
DNA polymerase catalytic subunit	0	1	0	1
DNA polymerase catalytic subunit	0	1	0	1
DNA polymerase alpha catalytic subunit	0	1	0	1
DNA polymerase delta catalytic subunit	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Serum paraoxonase/arylesterase 1	0	2	0	2
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Adenosine receptor A1	0	2	0	2
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	1	0	0	1
Metabotropic glutamate receptor 8	0	2	0	2
Metabotropic glutamate receptor 6	0	1	1	3
Excitatory amino acid transporter 4	0	1	0	1
Glutathione reductase, mitochondrial	0	3	0	3
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	1	1
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	0	2	1	3
Glutamate receptor 3	0	2	1	3
Glutamate receptor 4	0	2	1	3
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	1	2	3
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Excitatory amino acid transporter 1	0	2	0	3
Excitatory amino acid transporter 2	0	2	0	3
Excitatory amino acid transporter 3	0	2	0	3
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	2	0	2
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Metabotropic glutamate receptor 1	0	1	1	3
Metabotropic glutamate receptor 2	0	1	1	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	4
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	7	0	0	7
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
15-lipoxygenase, partial	6	0	0	6
Cocaine esterase	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Vitamin D-binding protein	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Integrin beta-1	0	1	0	1
Integrin alpha-4	0	1	0	1
Carbonyl reductase [NADPH] 1	0	0	0	1
C-8 sterol isomerase	0	1	0	1
Delta-type opioid receptor	0	4	1	6
Mu-type opioid receptor	0	4	1	8
Kappa-type opioid receptor	0	3	1	5
5-hydroxytryptamine receptor 2A	0	1	0	1
AP-2 complex subunit sigma	0	1	0	1
N-acetyltransferase Eis	0	2	0	2
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Calcitonin gene-related peptide type 1 receptor	0	1	0	1
Genome polyprotein	0	2	0	2
Zinc finger protein 664	0	1	0	1
Protease	0	3	1	4
Transient receptor potential cation channel subfamily V member 4	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Solute carrier family 22 member 3	0	2	0	3
Plasma kallikrein	0	0	0	3
Macrophage migration inhibitory factor	0	2	0	2
5-hydroxytryptamine receptor 1D	0	0	0	2
Carbonic anhydrase	0	1	0	5
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	2	0	2
Carbonic anhydrase	0	1	0	5
Carbonic anhydrase	0	1	0	5
Carbonic anhydrase	0	1	0	5
Solute carrier family 22 member 1	0	5	0	6
Carbonic anhydrase	0	1	0	5
Equilibrative nucleoside transporter 4	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carbonic anhydrase 4	0	1	0	3
Solute carrier family 22 member 2	0	4	0	5
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Histidine-binding periplasmic protein	0	0	1	1
Large neutral amino acids transporter small subunit 1	0	2	0	2
Glycogen synthase kinase-3 alpha	0	1	0	1
Protein cereblon	0	2	0	2
Genome polyprotein	0	1	0	1
Cyclic GMP-AMP synthase	0	2	0	2
Toll-like receptor 9	0	1	0	1
Toll-like receptor 7	0	1	0	1
Acid-sensing ion channel 3	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	2	0	3
Dihydrofolate reductase	0	5	0	5
Albumin	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	3
Prostaglandin G/H synthase 1	0	1	0	1
Caspase-1	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	3
Aldo-keto reductase family 1 member C3	0	2	0	2
Caspase-3	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	2	0	2
Caspase-4	0	1	0	1
Caspase-5	0	1	0	1
Caspase-9	0	1	0	1
Acid-sensing ion channel 1	0	1	0	1
Mu-type opioid receptor	0	4	0	4
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	3
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Sodium-dependent noradrenaline transporter	0	1	0	1
Envelope glycoprotein	0	0	1	1
Sodium-dependent serotonin transporter	0	1	0	1
Hsf1 protein	0	0	2	3
Capsid protein	0	1	1	2
chaperonin-containing TCP-1 beta subunit homolog	2	0	0	2
Synaptic vesicle glycoprotein 2A	0	2	0	2
Free fatty acid receptor 1	0	0	1	1
Sterol O-acyltransferase 1	0	1	0	1
Trypsin	0	1	0	1
Coagulation factor VII	0	1	0	1
Aromatase	0	2	0	2
Tissue factor	0	2	0	2
Tyrosine-protein phosphatase non-receptor type 7	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Dual specificity protein phosphatase 3	0	1	0	1
Peroxisome proliferator-activated receptor alpha	1	0	0	1
Free fatty acid receptor 4	0	0	1	1
huntingtin isoform 2	1	0	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Stromelysin-1	0	3	1	4
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	2	0	2
Matrix metalloproteinase-9	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Opioid receptor, delta 1b	0	1	0	1
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Histidine decarboxylase	0	0	1	1
Proteinase-activated receptor 1	0	1	1	2
Delta-type opioid receptor	0	2	0	3
Kappa-type opioid receptor	0	2	1	4
Mu-type opioid receptor	0	2	1	5
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Mu-type opioid receptor	0	1	0	1
Olfactory receptor 51E2	0	0	2	2
Polyphenol oxidase 2	0	2	0	3
Cholesteryl ester transfer protein	0	1	0	1
D-amino-acid oxidase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 3	0	0	1	1
Nicotinamidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	0	1	1
Hydroxycarboxylic acid receptor 2	0	2	1	3
D-aspartate oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	1	1	2
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
WRN	1	0	0	1
Valosin-containing protein	0	1	0	1
microphthalmia-associated transcription factor isoform 9	0	2	0	2
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
phosphoglycerate kinase	1	0	0	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Solute carrier family 22 member 8	0	2	0	3
Beta-lactamase 1	0	0	0	1
Beta-lactamase	0	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
rac GTPase-activating protein 1 isoform a	0	1	0	1
Cannabinoid receptor 1	0	2	0	2
Alpha-synuclein	0	4	0	4
Aldo-keto reductase family 1 member B1	0	1	0	1
Muscarinic acetylcholine receptor M1	0	0	1	1
Muscarinic acetylcholine receptor DM1	0	1	0	1
Cytochrome P450 2A13	0	1	1	2
Sterol 14-alpha-demethylase	0	0	1	1
14-alpha sterol demethylase	0	0	1	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Lanosterol 14-alpha demethylase	0	0	1	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	1	0	1
Sterol 14-alpha demethylase	0	0	1	1
Sterol 14-alpha demethylase	0	1	1	2
14-alpha sterol demethylase	0	0	1	1
14-alpha sterol demethylase	0	0	1	1
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
90-kda heat shock protein beta HSP90 beta, partial	0	2	0	2
heat shock protein HSP 90-alpha isoform 2	0	2	0	3
Serine hydroxymethyltransferase, mitochondrial	0	1	0	1
Chloroquine resistance transporter	0	1	0	1
alpha-galactosidase	2	0	0	2
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Canalicular multispecific organic anion transporter 1	0	1	0	1
Pannexin-1	0	1	0	1
Solute carrier family 22 member 12	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
UDP-glucuronosyltransferase 1A10	0	1	0	1
Pannexin-1	0	1	0	1
heat shock protein 90, putative	0	0	0	1
Pyridoxal kinase	0	0	0	1
dual specificity protein phosphatase 3	0	1	0	1
tyrosine-protein phosphatase non-receptor type 22 isoform 1	0	1	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
Estrogen receptor	0	0	1	1
Beta-hexosaminidase subunit alpha	0	1	0	2
Beta-hexosaminidase subunit beta	0	1	0	1
Dihydrofolate reductase	0	2	1	4
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Dihydrofolate reductase	0	2	0	2
Substance-K receptor	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Pteridine reductase 1	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Trace amine-associated receptor 5	0	0	1	1
Estrogen receptor beta	0	0	1	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Multidrug and toxin extrusion protein 1	0	1	0	1
Dihydrofolate reductase	0	1	0	1
N	0	1	0	1
NPYLR7B	0	0	1	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
cystic fibrosis transmembrane conductance regulator	0	1	0	1
tumor susceptibility gene 101 protein	1	0	0	1
DNA-directed RNA polymerase subunit alpha	0	1	0	1
DNA-directed RNA polymerase subunit omega	0	1	0	1
DNA-directed RNA polymerase subunit beta'	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	1
Acidic phospholipase A2 2	0	1	0	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Quinolone resistance protein NorA	0	1	0	2
DNA topoisomerase 1	0	1	0	1
Chromaffin granule amine transporter	0	1	0	1
Synaptic vesicular amine transporter	0	1	0	1
Synaptic vesicular amine transporter	0	2	1	3
Synaptic vesicular amine transporter	0	1	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Glycine receptor subunit alpha-1	0	2	1	3
Insulin-degrading enzyme	0	1	0	1
DNA repair protein RAD52 homolog	0	1	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	0	1
Gamma-aminobutyric acid receptor subunit rho-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit rho-2	0	0	0	1
Glycine receptor subunit beta	0	1	0	1
Taste receptor type 2 member 46	0	0	1	1
Taste receptor type 2 member 10	0	0	1	2
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2	0	1	1	2
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Carbonic anhydrase	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Protein argonaute-2	0	0	1	1
estrogen receptor beta isoform 1	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
72 kDa type IV collagenase	0	1	0	1
Neutrophil collagenase	0	1	0	1
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
Chain A, Pyridoxal kinase	0	1	0	1
Chain A, Pyridoxal Kinase	0	1	0	1
Phosphodiesterase	0	2	0	2
Renin	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	3	0	3
Intestinal-type alkaline phosphatase	0	2	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Adenosine receptor A1	0	2	0	2
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	2	2	5
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A1	0	2	1	5
Vasopressin V2 receptor	0	0	0	1
Adenosine receptor A2a	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
Adenosine receptor A1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	2	0	2
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
Adenosine receptor A2b	0	0	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	0	1	1
Endochitinase B1	0	1	0	1
Phospholipase A-2-activating protein	0	2	0	2
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Retinoic acid receptor RXR-alpha	0	0	2	2
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	2
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Tryptophan 2,3-dioxygenase	0	1	0	2
SLC16A10 protein	0	0	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Monocarboxylate transporter 10	0	0	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Histone deacetylase 3	0	2	0	2
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Histone deacetylase 4	0	2	0	2
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
Histone deacetylase 7	0	2	0	2
Polyamine deacetylase HDAC10	0	2	0	2
Histone deacetylase 11	0	2	0	2
Histone deacetylase 8	0	2	0	2
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
Histone deacetylase 9	0	2	0	2
Histone deacetylase 5	0	2	0	2
pyruvate kinase PKM isoform a	1	0	0	1
tyrosine-protein kinase Yes	1	0	0	1
Ectonucleoside triphosphate diphosphohydrolase 1	0	0	0	1
Thymidine kinase, cytosolic	0	2	0	3
Protein kinase C beta type	0	1	0	1
DNA polymerase beta	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	1
Thymidylate kinase	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Thymidine kinase	0	1	0	2
Thymidine kinase	0	1	0	2
twin arginine protein translocation system - TatA protein	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Central Nervous System Syphilis

Synonyms(17)

Research Excerpts

Overview

Context

Treatment

Research

Studies (538)

Protein Targets (1,283)

Central Nervous System Syphilis

Synonyms(17)

Research Excerpts

Overview

Context

Treatment

Research

Studies (538)

Drugs Studied (190)

Protein Targets (1,283)