Malignant Neurilemmoma

A malignant tumor that arises from small cutaneous nerves, is locally aggressive, and has a potential for metastasis. Characteristic histopathologic features include proliferating atypical spindle cells with slender wavy and pointed nuclei, hypocellular areas, and areas featuring organized whorls of fibroblastic proliferation. The most common primary sites are the extremities, retroperitoneum, and trunk. These tumors tend to present in childhood, often in association with NEUROFIBROMATOSIS 1. (From DeVita et al., Cancer: Principles & Practice of Oncology, 5th ed, p1662; Mayo Clin Proc 1990 Feb;65(2):164-72)

Synonym
Peripheral Nerve Sheath Tumors, Malignant
Sarcoma, Neurogenic
Malignant Neurilemoma
Schwannoma, Malignant
Neurofibrosarcoma
Neurilemmosarcoma
Malignant Peripheral Nerve Sheath Tumor
Malignant Neurilemmoma
MPNST
Malignant Peripheral Nerve Sheath Tumors

Excerpt	Reference
"The majority of neurogenic sarcomas are categorized and treated as soft tissue sarcomas, and only a few centers have sufficient experience to add to our understanding of these malignant tumors."	( Angelov, L; Bell, R; Davis, A; Guha, A; O'Sullivan, B, 1998)
"Neurofibrosarcoma is a rare malignant peripheral nerve sheath tumour."	( Baccari, S; Bahri, H; Ben Hamouda, M; Bergaoui, N; Chaabene, M; Jaafoura, H; Ladeb, F; Sghaier, S, 2002)
"MPNSTs (malignant peripheral nerve sheath tumors) are a highly malignant group of soft tissue sarcomas and carry a very poor prognosis."	( Kumar, R; Passah, A; Prashanth, A; Singhal, A; Tripathy, S, 2019)
"Melanotic malignant peripheral nerve sheath tumor is an extremely rare tumor, which originates from the neural crest, and more than half the cases are associated with Carney complex (myxomas, spotty pigmentation, and endocrine abnormalities)."	( Liu, C; Liu, E; Sun, T; Wang, S, 2019)
"However, MPNSTs are prone to sampling errors and biopsies or resections are cumbersome and possibly damaging in benign peripheral nerve sheath tumor (BPNST)."	( Coert, JH; Geitenbeek, RTJ; Graven, LH; Grünhagen, DJ; Hanff, DF; Martin, E; Taal, W; Verhoef, C, 2021)
"Malignant peripheral nerve sheath tumor is a rare tumor which infrequently involves the orbit."	( Jones, KE; Kunesh, MG; Patel, A; Thuro, BA, 2022)
"Primary lung MPNSTs are rare, and there is no established treatment for inoperable cases."	( Hanaoka, M; Koizumi, T; Nishie, K; Sano, K; Takahashi, H; Takei, K; Yamamoto, H; Yanagisawa, K, 2022)

Excerpt	Reference
"When deep and high-grade MPNSTs were compared with deep and high-grade STS, a more aggressive local treatment was applied to MPNSTs with a higher number of amputations for MPNSTs (32%) compared with STS (9%; p < 0."	( Brennan, MF; Vauthey, JN; Woodruff, JM, 1995)
"However, when treated aggressively, MPNSTs have an outcome similar to other deep and high-grade extremity STS."	( Brennan, MF; Vauthey, JN; Woodruff, JM, 1995)
"The majority of neurogenic sarcomas are categorized and treated as soft tissue sarcomas, and only a few centers have sufficient experience to add to our understanding of these malignant tumors."	( Angelov, L; Bell, R; Davis, A; Guha, A; O'Sullivan, B, 1998)
"A periocular neurofibrosarcoma was debulked and treated with intralesional cisplatin in a 5-year-old Thoroughbred mare."	( Strubbe, DT, 2001)
"Further analysis of the MPNST xenograft tumours resistant to AKT/mTOR treatment revealed a reactivation of both AKT and mTOR in several tumour samples."	( Ewald, F; Jiang, W; Jücker, M; Mautner, VF; Salamon, J; Schulte, A; Smit, DJ; Spyra, M, 2020)
"Giant MPNSTs of the scalp are highly aggressive lesions that should primarily be treated in a surgical fashion."	( Belo, D; Coiteiro, D; Cubas Farinha, N; Freitas, H, 2020)
"Starvation sensitized MPNST to treatment."	( Harder, A; Linke, C; Wösle, M, 2020)
"Aggressive MPNST cells are sensitive to 3-BrPA therapy in-vitro with and without starvation."	( Harder, A; Linke, C; Wösle, M, 2020)
"RAS pathway activation is common in MPNST, suggesting MEK pathway inhibition as a targeted therapy, but the impact on clinical outcome has been small to date."	( Butler, E; Geboers, S; Hao, G; Kim, J; Laetsch, TW; Nham, K; Schwettmann, B; Skapek, SX; Sun, X; Williams, NS; Xu, L, 2020)
"Primary lung MPNSTs are rare, and there is no established treatment for inoperable cases."	( Hanaoka, M; Koizumi, T; Nishie, K; Sano, K; Takahashi, H; Takei, K; Yamamoto, H; Yanagisawa, K, 2022)
"Treatment options for individuals with MPNSTs are disappointingly limited, with disfiguring surgery being the foremost treatment option."	( Carroll, SL; Guest, ST; Jenkins, DP; Longo, JF; Turner-Ivey, B, 2023)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	1 (1.79)	23.3326
1990's	7 (12.50)	12.5806
2000's	10 (17.86)	18.1394
2010's	7 (12.50)	28.8240
2020's	31 (55.36)	9.53

Drug	Relationship Strength	Studies	Trials
chlorine	low	1	0
salicylic acid	low	3	0
niacinamide	low	1	0
guanidine	low	1	0
ifosfamide	low	1	0
ketamine	low	1	0
propidium	low	1	0
glutamine	low	1	0
lysine	low	1	0
pyrroles	low	1	0
indazoles	medium	1	1
hydrazine	low	1	0
thymidine monophosphate	low	1	0
alpha-aminopyridine	low	1	0
gadolinium	low	1	0
propiconazole	low	2	0
carbogen	low	1	0
triazoles	low	1	0
fluorodeoxyglucose f18	low	8	0
ecteinascidin 743	low	1	0
technetium tc 99m pentetate	low	1	0
benzofurans	low	1	0
rocaglamide	low	1	0
dactinomycin	low	1	0
isomethyleugenol	low	4	0
maytansine	medium	1	1
sirolimus	low	2	0
everolimus	low	1	0
bromopyruvate	low	1	0
shu 508	low	1	0
3-aminopyridine-2-carboxaldehyde thiosemicarbazone	low	1	0
sincalide	low	1	0
mart-1 antigen	low	1	0
pazopanib	medium	1	1
azd 6244	low	2	0
crizotinib	low	1	0
trametinib	low	1	0
glucagon	low	1	0
mk 2206	low	1	0
entrectinib	low	1	0
pexidartinib	low	1	0
(5-(2,4-bis((3s)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol	low	1	0
epidermal growth factor	low	1	0
transforming growth factor beta	low	1	0
azd1208	low	1	0
selinexor	low	1	0
technetium tc 99m medronate	low	1	0
folic acid	low	1	0
lorvotuzumab mertansine	medium	1	1
pyrimidinones	low	1	0

Protein Targets (889)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
PPM1D protein	8	0	0	8
Bone morphogenetic protein receptor type-1B	0	0	12	12
Membrane-associated progesterone receptor component 1	0	0	10	10
Serine/threonine-protein kinase PLK4	0	0	12	12
ATP-dependent RNA helicase DDX3X	0	0	12	12
Pyridoxal kinase	0	0	12	12
Citron Rho-interacting kinase	0	0	12	12
Serine/threonine-protein kinase Chk1	0	1	12	13
Aurora kinase A	0	1	12	13
Cyclin-G-associated kinase	0	0	12	12
Ephrin type-B receptor 6	0	0	12	12
Peroxisomal acyl-coenzyme A oxidase 3	0	0	12	12
Receptor-interacting serine/threonine-protein kinase 2	0	0	12	12
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	12	12
Dynamin-like 120 kDa protein, mitochondrial	0	0	12	12
Eukaryotic translation initiation factor 5B	0	0	8	8
Rho-associated protein kinase 2	0	0	12	12
Serine/threonine-protein kinase ULK1	0	0	12	12
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	12	12
Ribosomal protein S6 kinase alpha-5	0	0	12	12
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	12	12
Ribosomal protein S6 kinase alpha-4	0	0	12	12
Serine/threonine-protein kinase 16	0	0	12	12
Serine/threonine-protein kinase 10	0	0	12	12
Serine/threonine-protein kinase D3	0	0	12	12
Structural maintenance of chromosomes protein 2	0	0	12	12
Mitogen-activated protein kinase kinase kinase 6	0	0	12	12
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	12	12
Serine/threonine-protein kinase LATS1	0	0	12	12
Serine/threonine-protein kinase PAK 4	0	1	12	13
Tyrosine-protein kinase ABL1	0	3	12	15
Epidermal growth factor receptor	0	4	12	16
Interferon beta	10	0	0	10
High affinity nerve growth factor receptor	0	3	12	15
Guanine nucleotide-binding protein G(i) subunit alpha-2	0	0	10	10
ADP/ATP translocase 2	0	0	12	12
Protein kinase C beta type	0	1	12	13
Insulin receptor	0	2	12	14
Tyrosine-protein kinase Lck	0	2	12	14
Tyrosine-protein kinase Fyn	0	1	12	13
Cyclin-dependent kinase 1	0	2	12	14
Glycogen phosphorylase, liver form	0	0	12	12
Tyrosine-protein kinase Fes/Fps	0	0	12	12
Adenine phosphoribosyltransferase	0	0	9	9
Tyrosine-protein kinase Yes	0	0	12	12
Tyrosine-protein kinase Lyn	0	0	12	12
Proto-oncogene tyrosine-protein kinase receptor Ret	0	2	12	14
Insulin-like growth factor 1 receptor	0	2	12	14
Signal recognition particle receptor subunit alpha	0	0	12	12
Cytochrome c1, heme protein, mitochondrial	0	0	12	12
Hepatocyte growth factor receptor	0	5	12	18
Tyrosine-protein kinase HCK	0	0	12	12
Platelet-derived growth factor receptor beta	0	5	12	17
Serine/threonine-protein kinase A-Raf	0	0	12	12
Glycogen phosphorylase, brain form	0	0	12	12
Breakpoint cluster region protein	0	0	12	12
Serine/threonine-protein kinase pim-1	0	3	12	15
Fibroblast growth factor receptor 1	0	3	12	15
DNA topoisomerase 2-alpha	0	0	12	12
Cyclin-dependent kinase 4	0	0	12	12
ADP/ATP translocase 3	0	0	12	12
Inosine-5'-monophosphate dehydrogenase 2	0	0	12	12
Proto-oncogene tyrosine-protein kinase Src	0	1	12	13
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	12	12
Serine/threonine-protein kinase B-raf	0	0	12	12
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	12	12
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	0	12	12
Tyrosine-protein kinase Fer	0	0	12	12
Protein kinase C alpha type	0	0	12	12
cAMP-dependent protein kinase catalytic subunit alpha	0	1	12	13
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	12	12
Casein kinase II subunit alpha'	0	1	12	13
Ras-related protein Rab-6A	0	0	10	10
Ephrin type-A receptor 1	0	0	11	11
Multifunctional protein ADE2	0	0	12	12
cAMP-dependent protein kinase catalytic subunit gamma	0	0	10	10
cAMP-dependent protein kinase catalytic subunit beta	0	0	12	12
Ferrochelatase, mitochondrial	0	0	12	12
Ribosomal protein S6 kinase beta-1	0	1	12	13
Tyrosine-protein kinase JAK1	0	2	12	14
Cyclin-dependent kinase 2	0	2	12	14
Beta-adrenergic receptor kinase 1	0	0	12	12
Probable ATP-dependent RNA helicase DDX6	0	0	12	12
Mitogen-activated protein kinase 3	0	0	12	12
MAP/microtubule affinity-regulating kinase 3	0	0	12	12
Deoxycytidine kinase	0	0	12	12
Phosphatidylinositol 3-kinase regulatory subunit alpha	0	1	0	1
Mitogen-activated protein kinase 1	0	1	12	13
Ephrin type-A receptor 2	0	2	12	14
Ephrin type-B receptor 2	0	1	12	13
Non-receptor tyrosine-protein kinase TYK2	0	1	12	13
UMP-CMP kinase	0	0	9	9
Phosphatidylethanolamine-binding protein 1	0	0	11	11
Wee1-like protein kinase	0	0	12	12
Heme oxygenase 2	0	0	11	11
S-adenosylmethionine synthase isoform type-2	0	0	11	11
DnaJ homolog subfamily A member 1	0	0	12	12
RAC-alpha serine/threonine-protein kinase	0	3	12	15
RAC-beta serine/threonine-protein kinase	0	2	12	14
Dual specificity protein kinase TTK	0	1	10	11
DNA replication licensing factor MCM4	0	0	12	12
Myosin-10	0	0	11	11
Dual specificity mitogen-activated protein kinase kinase 2	0	2	12	14
Receptor-type tyrosine-protein kinase FLT3	0	4	12	16
Bone morphogenetic protein receptor type-1A	0	0	12	12
Activin receptor type-1B	0	0	12	12
TGF-beta receptor type-1	0	0	12	12
TGF-beta receptor type-2	0	0	11	11
Electron transfer flavoprotein subunit beta	0	0	9	9
Tyrosine-protein kinase CSK	0	0	12	12
Glycine--tRNA ligase	0	0	12	12
Protein kinase C iota type	0	0	12	12
Exosome RNA helicase MTR4	0	0	12	12
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	1	4	5
Serine/threonine-protein kinase mTOR	0	3	6	9
Tyrosine-protein kinase Tec	0	0	12	12
Tyrosine-protein kinase ABL2	0	0	12	12
Tyrosine-protein kinase FRK	0	0	12	12
G protein-coupled receptor kinase 6	0	0	9	9
Tyrosine-protein kinase SYK	0	1	12	13
26S proteasome regulatory subunit 6B	0	0	12	12
Mitogen-activated protein kinase 8	0	0	12	12
Mitogen-activated protein kinase 9	0	0	12	12
Dual specificity mitogen-activated protein kinase kinase 4	0	0	6	6
Dual specificity mitogen-activated protein kinase kinase 3	0	0	12	12
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	12	12
Casein kinase I isoform alpha	0	0	12	12
Casein kinase I isoform delta	0	0	12	12
MAP kinase-activated protein kinase 2	0	1	12	13
Elongation factor Tu, mitochondrial	0	0	12	12
Cysteine--tRNA ligase, cytoplasmic	0	0	12	12
Casein kinase I isoform epsilon	0	0	12	12
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	12	12
Dual specificity protein kinase CLK1	0	0	11	11
Dual specificity protein kinase CLK2	0	0	12	12
Glycogen synthase kinase-3 alpha	0	0	12	12
Glycogen synthase kinase-3 beta	0	1	12	13
Cyclin-dependent kinase 7	0	1	12	13
Cyclin-dependent kinase 9	0	0	12	12
Ras-related protein Rab-27A	0	0	12	12
Interleukin-1 receptor-associated kinase 1	0	0	12	12
Ribosomal protein S6 kinase alpha-3	0	0	12	12
Serine/threonine-protein kinase Nek2	0	0	12	12
Serine/threonine-protein kinase Nek3	0	0	12	12
Dual specificity mitogen-activated protein kinase kinase 6	0	0	12	12
LIM domain kinase 1	0	0	12	12
LIM domain kinase 2	0	0	12	12
Mitogen-activated protein kinase 10	0	0	12	12
Tyrosine--tRNA ligase, cytoplasmic	0	0	12	12
5'-AMP-activated protein kinase subunit gamma-1	0	0	12	13
Ephrin type-B receptor 3	0	0	12	12
Ephrin type-A receptor 5	0	0	11	11
Ephrin type-B receptor 4	0	1	12	13
Ephrin type-A receptor 4	0	0	12	12
Adenylate kinase 2, mitochondrial	0	0	12	12
Adenosine kinase	0	0	12	12
Ras-related protein Rab-10	0	0	12	12
Actin-related protein 3	0	0	12	12
Actin-related protein 2	0	0	12	12
GTP-binding nuclear protein Ran	0	0	12	12
Casein kinase I isoform gamma-2	0	0	12	12
Cyclin-dependent kinase 3	0	0	11	11
Cyclin-dependent kinase 6	0	0	11	11
Cyclin-dependent-like kinase 5	0	0	12	12
Cyclin-dependent kinase 16	0	0	12	12
Cyclin-dependent kinase 17	0	0	11	11
ATP-dependent 6-phosphofructokinase, platelet type	0	0	11	11
Dual specificity mitogen-activated protein kinase kinase 1	0	2	12	14
DNA topoisomerase 2-beta	0	0	12	12
Protein kinase C theta type	0	0	11	11
Activin receptor type-1	0	0	12	12
Macrophage-stimulating protein receptor	0	2	12	14
Focal adhesion kinase 1	0	1	12	13
Protein kinase C zeta type	0	0	5	5
Protein kinase C delta type	0	0	12	12
Tyrosine-protein kinase BTK	0	1	12	13
Activated CDC42 kinase 1	0	1	12	13
Epithelial discoidin domain-containing receptor 1	0	0	12	12
Potassium voltage-gated channel subfamily H member 2	0	3	0	3
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	12	12
Serine/threonine-protein kinase 4	0	0	12	12
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	12	13
Dual specificity mitogen-activated protein kinase kinase 5	0	0	12	12
Mitogen-activated protein kinase 7	0	0	11	11
Serine/threonine-protein kinase PAK 2	0	0	11	11
Serine/threonine-protein kinase 3	0	0	12	12
Mitogen-activated protein kinase kinase kinase 1	0	0	12	12
Integrin-linked protein kinase	0	0	12	12
Rho-associated protein kinase 1	0	0	12	12
Non-receptor tyrosine-protein kinase TNK1	0	0	12	12
Serine/threonine-protein kinase ATR	0	0	3	3
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	12	12
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	12	12
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	12	12
Activin receptor type-2B	0	0	12	12
Bone morphogenetic protein receptor type-2	0	0	12	12
Protein-tyrosine kinase 6	0	1	12	13
cGMP-dependent protein kinase 1	0	0	12	12
Cyclin-dependent kinase 13	0	0	12	12
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	12	12
Protein-tyrosine kinase 2-beta	0	0	12	12
Maternal embryonic leucine zipper kinase	0	1	12	13
Structural maintenance of chromosomes protein 1A	0	0	12	12
Chromodomain-helicase-DNA-binding protein 4	0	0	12	12
Peroxisomal acyl-coenzyme A oxidase 1	0	0	11	11
Ephrin type-A receptor 7	0	0	11	11
Delta(24)-sterol reductase	0	0	12	12
Ribosomal protein S6 kinase alpha-1	0	0	12	12
Dual specificity testis-specific protein kinase 1	0	0	11	11
Myosin light chain kinase, smooth muscle	0	0	12	12
Mitogen-activated protein kinase 11	0	0	12	12
Serine/threonine-protein kinase STK11	0	0	12	12
Serine/threonine-protein kinase N1	0	0	12	12
Serine/threonine-protein kinase N2	0	1	12	13
Mitogen-activated protein kinase 14	0	2	12	14
Calcium/calmodulin-dependent protein kinase type IV	0	0	11	11
Mitogen-activated protein kinase kinase kinase 11	0	0	12	12
Discoidin domain-containing receptor 2	0	2	12	14
AP2-associated protein kinase 1	0	0	12	12
Myosin light chain kinase 3	0	0	11	11
Putative heat shock protein HSP 90-beta 2	0	0	12	12
Rab-like protein 3	0	0	10	10
Serine/threonine-protein kinase MRCK alpha	0	0	12	12
Serine/threonine-protein kinase MRCK gamma	0	0	12	12
Acyl-CoA dehydrogenase family member 10	0	0	12	12
Serine/threonine-protein kinase N3	0	0	9	9
Serine/threonine-protein kinase ULK3	0	0	12	12
Rapamycin-insensitive companion of mTOR	0	1	0	1
Uncharacterized protein FLJ45252	0	0	12	12
Acyl-CoA dehydrogenase family member 11	0	0	12	12
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	12	12
Serine/threonine-protein kinase MARK2	0	0	12	12
ATP-dependent RNA helicase DHX30	0	0	11	11
Serine/threonine-protein kinase TAO1	0	0	12	12
STE20-related kinase adapter protein alpha	0	0	12	12
Myosin-14	0	0	11	11
AarF domain-containing protein kinase 1	0	0	12	12
ATP-dependent RNA helicase DDX42	0	0	11	11
Mitogen-activated protein kinase kinase kinase kinase 3	0	1	12	13
MAP kinase-activated protein kinase 5	0	0	11	11
Regulatory-associated protein of mTOR	0	3	0	3
Misshapen-like kinase 1	0	0	9	9
Atypical kinase COQ8A, mitochondrial	0	0	12	12
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	12	12
Mitogen-activated protein kinase 15	0	0	12	12
Serine/threonine-protein kinase Nek9	0	0	12	12
Serine/threonine-protein kinase Nek7	0	0	8	8
ATP-dependent RNA helicase DDX1	0	0	12	12
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	12	12
Aurora kinase B	0	2	12	14
MAP/microtubule affinity-regulating kinase 4	0	0	11	11
Serine/threonine-protein kinase Nek1	0	0	12	12
PAS domain-containing serine/threonine-protein kinase	0	0	8	8
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	12	12
EKC/KEOPS complex subunit TP53RK	0	0	12	12
Dual specificity testis-specific protein kinase 2	0	0	8	8
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	12	12
Mitogen-activated protein kinase kinase kinase 5	0	0	12	12
Mitogen-activated protein kinase kinase kinase 3	0	0	12	12
Target of rapamycin complex 2 subunit MAPKAP1	0	1	0	1
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	12	12
Target of rapamycin complex subunit LST8	0	3	0	3
Nucleolar GTP-binding protein 1	0	0	12	12
Serine/threonine-protein kinase D2	0	0	12	12
NUAK family SNF1-like kinase 2	0	0	11	11
RNA cytidine acetyltransferase	0	0	12	12
Serine/threonine-protein kinase SIK2	0	0	12	12
STE20-like serine/threonine-protein kinase	0	0	12	12
Serine/threonine-protein kinase TAO3	0	0	12	12
dCTP pyrophosphatase 1	0	0	12	12
Dual specificity protein kinase CLK4	0	0	10	10
Casein kinase I isoform gamma-1	0	0	12	12
Serine/threonine-protein kinase PAK 6	0	0	7	7
Phenylalanine--tRNA ligase beta subunit	0	0	12	12
Isoleucine--tRNA ligase, mitochondrial	0	0	9	9
BMP-2-inducible protein kinase	0	0	12	12
Obg-like ATPase 1	0	0	11	11
Midasin	0	0	12	12
Interleukin-1 receptor-associated kinase 4	0	0	12	12
Mitogen-activated protein kinase kinase kinase 20	0	0	12	12
Cyclin-dependent kinase 12	0	0	12	12
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	11	11
Serine/threonine-protein kinase pim-2	0	2	8	10
Serine/threonine-protein kinase 26	0	1	12	13
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	12	12
Serine/threonine-protein kinase NLK	0	0	12	12
5'-AMP-activated protein kinase subunit gamma-2	0	0	12	13
Serine/threonine-protein kinase TBK1	0	0	12	12
Septin-9	0	0	12	12
Ribosomal protein S6 kinase alpha-6	0	0	12	12
TRAF2 and NCK-interacting protein kinase	0	0	12	12
Serine/threonine-protein kinase TAO2	0	0	12	12
Serine/threonine-protein kinase ICK	0	0	11	11
RAC-gamma serine/threonine-protein kinase	0	1	12	13
Serine/threonine-protein kinase 38-like	0	0	6	6
Serine/threonine-protein kinase SIK3	0	0	12	12
Mitogen-activated protein kinase kinase kinase 2	0	0	12	12
Thyroid hormone receptor-associated protein 3	0	0	9	9
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	8	8
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	12	12
Receptor-interacting serine/threonine-protein kinase 3	0	0	12	12
Serine/threonine-protein kinase MRCK beta	0	0	12	12
Interleukin-1 receptor-associated kinase 3	0	0	12	12
Serine/threonine-protein kinase 24	0	0	11	11
Casein kinase I isoform gamma-3	0	0	12	12
Mitogen-activated protein kinase kinase kinase 4	0	0	12	12
Ribonucleoside-diphosphate reductase subunit M2	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
AR protein	11	0	0	11
retinoic acid nuclear receptor alpha variant 1	6	0	0	6
estrogen nuclear receptor alpha	14	0	0	14
thyroid stimulating hormone receptor	3	0	0	3
thyroid hormone receptor beta isoform 2	10	0	0	10
Voltage-dependent calcium channel gamma-2 subunit	4	0	0	4
Heat shock protein HSP 90-alpha	0	0	2	2
Botulinum neurotoxin type A	0	1	0	1
Neutrophil cytosol factor 1	0	1	0	1
Glutamate receptor 2	4	0	0	4
Nitric oxide synthase, endothelial	0	1	0	1
Nitric oxide synthase, brain	0	2	0	2
Nitric oxide synthase, brain	0	1	0	1
Nitric oxide synthase, inducible	0	1	0	1
Kappa-type opioid receptor	0	1	1	2
Phosphatidylinositol 4-kinase alpha	0	1	0	1
Mu-type opioid receptor	0	0	1	1
Tyrosine-protein kinase	0	0	1	1
Phosphatidylinositol 4-kinase type 2-beta	0	1	0	1
Phosphatidylinositol 4-kinase type 2-alpha	0	1	0	1
Phosphatidylinositol 4-kinase beta	0	1	4	5
Leukotriene C4 synthase	0	0	4	4
RAR-related orphan receptor gamma	6	0	0	6
nuclear receptor subfamily 1, group I, member 3	5	0	0	5
cytochrome P450 family 3 subfamily A polypeptide 4	6	0	0	6
EWS/FLI fusion protein	8	0	0	8
G	4	0	0	4
peroxisome proliferator-activated receptor delta	5	0	0	5
aryl hydrocarbon receptor	7	0	0	7
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	7	0	0	7
nuclear factor erythroid 2-related factor 2 isoform 1	6	0	0	6
Cell division cycle 7-related protein kinase	0	1	9	10
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	0	4	4
Serine/threonine-protein kinase 25	0	0	4	4
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	0	4	4
Serine/threonine-protein kinase RIO3	0	0	4	4
Dual specificity mitogen-activated protein kinase kinase 7	0	0	4	4
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	1	4	6
Peripheral plasma membrane protein CASK	0	0	4	4
Serine/threonine-protein kinase DCLK1	0	0	4	4
Inhibitor of nuclear factor kappa-B kinase subunit alpha	0	0	4	4
Muscle, skeletal receptor tyrosine-protein kinase	0	0	4	4
Mitogen-activated protein kinase 13	0	0	4	4
3-phosphoinositide-dependent protein kinase 1	0	1	4	5
Mitogen-activated protein kinase kinase kinase 13	0	0	4	4
Death-associated protein kinase 3	0	0	4	4
Mitogen-activated protein kinase kinase kinase 7	0	0	4	4
NUAK family SNF1-like kinase 1	0	0	4	4
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	0	0	4	4
Tyrosine-protein kinase JAK2	0	2	6	8
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	0	0	4	4
Serine/threonine-protein kinase PAK 3	0	0	4	4
Cyclin-dependent kinase-like 5	0	0	8	8
Serine/threonine-protein kinase 17B	0	0	4	4
Cyclin-dependent kinase 14	0	0	4	4
Serine/threonine-protein kinase OSR1	0	0	4	4
Serine/threonine-protein kinase Chk2	0	0	4	4
HLA class I histocompatibility antigen, B alpha chain	4	0	0	4
RAF proto-oncogene serine/threonine-protein kinase	0	0	4	4
Receptor tyrosine-protein kinase erbB-2	0	1	4	5
Cellular tumor antigen p53	9	0	0	9
Macrophage colony-stimulating factor 1 receptor	0	3	4	7
Proto-oncogene tyrosine-protein kinase ROS	0	5	4	9
Tyrosine-protein kinase Fgr	0	1	7	8
Wee1-like protein kinase 2	0	0	4	4
Uncharacterized serine/threonine-protein kinase SBK3	0	0	4	4
Mast/stem cell growth factor receptor Kit	0	4	4	8
Insulin receptor-related protein	0	0	4	4
Platelet-derived growth factor receptor alpha	0	4	4	8
Vascular endothelial growth factor receptor 1	0	3	4	7
Interferon-induced, double-stranded RNA-activated protein kinase	0	0	4	4
Serine/threonine-protein kinase MAK	0	0	4	4
Cyclin-dependent kinase 11B	0	0	4	4
Fibroblast growth factor receptor 2	0	1	4	5
Receptor tyrosine-protein kinase erbB-3	0	0	4	4
Fibroblast growth factor receptor 4	0	0	4	4
Fibroblast growth factor receptor 3	0	1	4	5
Protein kinase C eta type	0	0	4	4
Activin receptor type-2A	0	0	4	4
Ephrin type-A receptor 3	0	0	4	4
Ephrin type-A receptor 8	0	0	4	4
Leukocyte tyrosine kinase receptor	0	0	4	4
Tyrosine-protein kinase receptor UFO	0	2	4	6
Mitogen-activated protein kinase 4	0	0	4	4
G protein-coupled receptor kinase 4	0	0	4	4
Prostaglandin G/H synthase 2	0	1	4	5
Tyrosine-protein kinase receptor Tie-1	0	0	4	4
Vascular endothelial growth factor receptor 3	0	3	4	7
Vascular endothelial growth factor receptor 2	0	5	4	10
Serine/threonine-protein kinase receptor R3	0	0	6	6
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	0	4	4
Megakaryocyte-associated tyrosine-protein kinase	0	0	4	4
Tyrosine-protein kinase TXK	0	0	4	4
Tyrosine-protein kinase ZAP-70	0	1	4	5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	0	4	4
Cyclin-dependent kinase 8	0	0	4	4
Choline-phosphate cytidylyltransferase A	0	0	7	7
Dual specificity protein kinase CLK3	0	0	7	7
Tyrosine-protein kinase Blk	0	0	4	4
Cytoplasmic tyrosine-protein kinase BMX	0	1	4	5
cAMP-dependent protein kinase catalytic subunit PRKX	0	0	4	4
Serine/threonine-protein kinase Nek4	0	0	4	4
Tyrosine-protein kinase JAK3	0	2	4	6
Serine/threonine-protein kinase PLK1	0	1	9	10
Death-associated protein kinase 1	0	0	4	4
Mitogen-activated protein kinase 12	0	0	4	4
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	4	5
Ephrin type-B receptor 1	0	0	4	4
Hormonally up-regulated neu tumor-associated kinase	0	0	4	4
Serine/threonine-protein kinase SIK1	0	0	4	4
Receptor-interacting serine/threonine-protein kinase 4	0	0	4	4
Cell division control protein 2 homolog	0	0	4	4
Calcium-dependent protein kinase 1	0	0	4	4
Casein kinase II subunit alpha	0	1	4	5
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	0	0	4	4
SRSF protein kinase 2	0	0	4	4
Mitogen-activated protein kinase kinase kinase 9	0	0	4	4
Serine/threonine-protein kinase PknB	0	0	4	4
Cyclin-dependent kinase-like 1	0	0	4	4
Protein kinase C epsilon type	0	0	4	4
Angiopoietin-1 receptor	0	2	4	6
Mitogen-activated protein kinase kinase kinase 10	0	0	4	4
Tyrosine-protein kinase receptor TYRO3	0	1	4	5
Cyclin-dependent kinase 18	0	0	6	6
Tyrosine-protein kinase ITK/TSK	0	0	4	4
Myotonin-protein kinase	0	0	4	4
Mitogen-activated protein kinase kinase kinase 12	0	0	4	4
Tyrosine-protein kinase Mer	0	1	8	9
Serine/threonine-protein kinase PAK 1	0	0	4	4
cGMP-dependent protein kinase 2	0	0	4	4
Serine/threonine-protein kinase PRP4 homolog	0	0	4	4
Receptor-interacting serine/threonine-protein kinase 1	0	1	4	5
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	0	4	4
Calcium/calmodulin-dependent protein kinase type 1	0	0	4	4
Serine/threonine-protein kinase D1	0	1	4	5
Serine/threonine-protein kinase 38	0	0	5	5
Receptor tyrosine-protein kinase erbB-4	0	0	4	4
Ribosomal protein S6 kinase alpha-2	0	0	4	4
Rhodopsin kinase GRK1	0	0	4	4
NT-3 growth factor receptor	0	1	4	5
BDNF/NT-3 growth factors receptor	0	2	4	6
Mitogen-activated protein kinase 6	0	0	4	4
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	0	0	4	4
Serine/threonine-protein kinase SBK1	0	0	4	4
Mitogen-activated protein kinase kinase kinase 19	0	0	4	4
Serine/threonine-protein kinase TNNI3K	0	0	4	4
Leucine-rich repeat serine/threonine-protein kinase 2	0	0	4	4
Serine/threonine-protein kinase Nek5	0	0	4	4
Dual serine/threonine and tyrosine protein kinase	0	0	4	4
Mitogen-activated protein kinase kinase kinase 15	0	0	4	4
Serine/threonine-protein kinase tousled-like 2	0	0	4	4
Serine/threonine-protein kinase 32C	0	0	4	4
Serine/threonine-protein kinase pim-3	0	2	4	6
Serine/threonine-protein kinase VRK2	0	0	4	4
Myosin light chain kinase family member 4	0	0	4	4
Homeodomain-interacting protein kinase 1	0	1	4	5
Calcium/calmodulin-dependent protein kinase type 1D	0	0	4	4
Cyclin-dependent kinase-like 3	0	1	4	5
Serine/threonine-protein kinase BRSK2	0	0	4	4
Serine/threonine-protein kinase NIM1	0	1	4	5
Serine/threonine-protein kinase ULK2	0	0	4	4
Serine/threonine-protein kinase DCLK2	0	0	4	4
Calcium/calmodulin-dependent protein kinase kinase 1	0	0	4	4
Casein kinase I isoform alpha-like	0	0	4	4
Homeodomain-interacting protein kinase 4	0	1	4	5
Myosin-IIIa	0	0	4	4
Ankyrin repeat and protein kinase domain-containing protein 1	0	0	4	4
Serine/threonine-protein kinase Nek11	0	0	4	4
Serine/threonine-protein kinase BRSK1	0	0	4	4
Serine/threonine-protein kinase 35	0	0	4	4
Rhodopsin kinase GRK7	0	0	4	4
Serine/threonine-protein kinase 32A	0	0	4	4
Myosin-IIIb	0	0	4	4
Inositol hexakisphosphate kinase 1	4	0	0	4
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	0	4	4
Cyclin-dependent kinase-like 2	0	0	4	4
Serine/threonine-protein kinase Sgk3	0	0	4	4
Atypical kinase COQ8B, mitochondrial	0	0	4	4
Calcium/calmodulin-dependent protein kinase type 1G	0	0	5	5
Cyclin-dependent kinase 15	0	0	4	4
SRSF protein kinase 1	0	0	4	4
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	0	0	4	4
Serine/threonine-protein kinase RIO1	0	0	4	4
MAP kinase-interacting serine/threonine-protein kinase 1	0	0	4	4
Serine/threonine-protein kinase RIO2	0	0	4	4
Cyclin-dependent kinase 19	0	0	4	4
Transient receptor potential cation channel subfamily M member 6	0	0	4	4
Testis-specific serine/threonine-protein kinase 1	0	0	4	4
Serine/threonine-protein kinase 33	0	0	4	4
Serine/threonine-protein kinase DCLK3	0	0	4	4
Myosin light chain kinase 2, skeletal/cardiac muscle	0	0	4	4
Homeodomain-interacting protein kinase 2	0	1	4	5
Tyrosine-protein kinase Srms	0	0	4	4
Homeodomain-interacting protein kinase 3	0	1	4	5
Serine/threonine-protein kinase PLK3	0	0	4	4
MAP kinase-interacting serine/threonine-protein kinase 2	0	0	4	4
Serine/threonine-protein kinase Nek6	0	1	4	5
SNF-related serine/threonine-protein kinase	0	0	4	4
Serine/threonine-protein kinase LATS2	0	0	4	4
Serine/threonine-protein kinase 36	0	0	4	4
Serine/threonine-protein kinase 32B	0	0	4	4
Serine/threonine-protein kinase PLK2	0	0	4	4
Serine/threonine-protein kinase MARK1	0	0	4	4
Serine/threonine-protein kinase PAK 5	0	0	4	4
eIF-2-alpha kinase GCN2	0	0	4	4
Serine/threonine-protein kinase 17A	0	0	4	4
STE20/SPS1-related proline-alanine-rich protein kinase	0	0	4	4
Ephrin type-A receptor 6	0	0	4	4
Death-associated protein kinase 2	0	0	4	4
Serine/threonine-protein kinase tousled-like 1	0	0	4	4
Long-chain-fatty-acid--CoA ligase 5	0	0	8	8
ALK tyrosine kinase receptor	0	6	6	12
SRSF protein kinase 3	0	0	4	4
Cyclin-dependent kinase 11A	0	0	4	4
Aurora kinase C	0	0	4	4
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	0	4	4
Microtubule-associated serine/threonine-protein kinase 1	0	0	4	4
cytochrome P450 2C9, partial	4	0	0	4
Uncharacterized aarF domain-containing protein kinase 5	0	0	6	6
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	0	0	3	3
Carbonic anhydrase 1	0	3	0	4
Carbonic anhydrase 2	0	3	0	4
Carbonic anhydrase 4	0	2	0	2
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 15	0	2	0	2
Fumarate hydratase	6	0	0	6
cytochrome P450 2D6	4	0	0	4
polyprotein	6	0	0	6
tyrosine-protein kinase Yes	4	0	0	4
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2	0	1	0	1
Sodium-dependent phosphate transport protein 2B	0	1	0	1
Tyrosine-protein kinase ABL1	0	1	0	1
HLA class II histocompatibility antigen gamma chain	0	1	0	1
Nucleophosmin	0	1	0	1
Cytochrome P450 3A4	0	4	1	5
Androgen receptor	0	1	0	1
G2/mitotic-specific cyclin-B1	0	2	0	2
ALK tyrosine kinase receptor	0	1	0	1
Angiopoietin-1 receptor	0	1	0	1
Lysine--tRNA ligase	0	1	0	1
Cyclin-dependent kinase 10	0	0	3	3
Sigma intracellular receptor 2	0	1	0	1
Macrophage-stimulating protein receptor	0	1	0	1
Mixed lineage kinase domain-like protein	0	0	1	1
Echinoderm microtubule-associated protein-like 4	0	2	0	2
Aurora kinase A-interacting protein	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	6	0	0	6
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Chain A, HADH2 protein	2	0	0	2
Chain B, HADH2 protein	2	0	0	2
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
Chain A, Ferritin light chain	5	0	0	5
Chain A, Cruzipain	1	0	0	1
interleukin 8	1	0	0	1
15-lipoxygenase, partial	2	0	0	2
hypoxia-inducible factor 1 alpha subunit	2	0	0	2
USP1 protein, partial	5	0	0	5
TDP1 protein	11	0	0	11
GLI family zinc finger 3	8	0	0	8
Microtubule-associated protein tau	2	0	0	2
caspase 7, apoptosis-related cysteine protease	1	0	0	1
aldehyde dehydrogenase 1 family, member A1	3	0	0	3
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
estrogen receptor 2 (ER beta)	4	0	0	4
progesterone receptor	3	0	0	3
glucocorticoid receptor [Homo sapiens]	7	0	0	7
retinoid X nuclear receptor alpha	7	0	0	7
estrogen-related nuclear receptor alpha	8	0	0	8
farnesoid X nuclear receptor	5	0	0	5
pregnane X nuclear receptor	7	0	0	7
peroxisome proliferator activated receptor gamma	7	0	0	7
vitamin D (1,25- dihydroxyvitamin D3) receptor	3	0	0	3
caspase-3	1	0	0	1
RAD51	0	1	0	1
euchromatic histone-lysine N-methyltransferase 2	4	0	0	4
activating transcription factor 6	3	0	0	3
v-jun sarcoma virus 17 oncogene homolog (avian)	2	0	0	2
Histone H2A.x	2	0	0	2
Caspase-7	2	0	0	2
Bloom syndrome protein isoform 1	4	0	0	4
vitamin D3 receptor isoform VDRA	4	0	0	4
thyroid hormone receptor beta isoform a	4	0	0	4
caspase-3	2	0	0	2
huntingtin isoform 2	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
nuclear receptor ROR-gamma isoform 1	6	0	0	6
peripheral myelin protein 22	3	0	0	3
survival motor neuron protein isoform d	2	0	0	2
cytochrome P450 3A4 isoform 1	2	0	0	2
caspase-1 isoform alpha precursor	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	2	0	0	2
ATP-dependent translocase ABCB1	0	1	1	3
Gamma-aminobutyric acid receptor subunit beta-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit delta	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	2	0	0	2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1	0	1	0	1
Nuclear receptor ROR-gamma	1	0	0	1
Caspase-7	2	0	0	2
Spike glycoprotein	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-1	2	0	0	2
Growth factor receptor-bound protein 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-2	2	0	0	2
Pantothenate synthetase	0	1	0	1
Growth factor receptor-bound protein 2	0	1	0	1
Reverse transcriptase/RNaseH	0	1	0	1
GABA theta subunit	2	0	0	2
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase	0	0	1	1
ATPase family AAA domain-containing protein 5	6	0	0	6
Ataxin-2	6	0	0	6
Gamma-aminobutyric acid receptor subunit epsilon	2	0	0	2
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
Eukaryotic elongation factor 2 kinase	0	1	0	1
Putative nucleoside diphosphate kinase	0	0	1	1
Cyclin-A2	0	2	0	2
Nucleoside diphosphate kinase B	0	0	2	2
Casein kinase II subunit beta	0	1	0	1
MAP kinase-activated protein kinase 3	0	0	5	5
Serine/threonine-protein kinase LMTK3	0	1	0	1
Eukaryotic translation initiation factor 2-alpha kinase 3	0	1	0	1
Protein DBF4 homolog A	0	1	0	1
geminin	8	0	0	8
ATP-binding cassette sub-family C member 3	0	4	0	4
Multidrug resistance-associated protein 4	0	4	0	5
Bile salt export pump	0	7	0	7
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	4	0	4
Potassium voltage-gated channel subfamily D member 3	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	1	0	0	1
Chain A, Dihydrofolate reductase	0	0	1	1
Chain A, 2-oxoglutarate Oxygenase	4	0	0	4
acid sphingomyelinase	2	0	0	2
glp-1 receptor, partial	4	0	0	4
thyroid stimulating hormone receptor	1	0	0	1
glucocerebrosidase	1	0	0	1
alpha-galactosidase	1	0	0	1
lysosomal alpha-glucosidase preproprotein	3	0	0	3
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 2	2	0	0	2
DNA polymerase beta	2	0	0	2
Thymidylate synthase	0	2	0	2
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	0	1	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Alpha-synuclein	4	0	0	4
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Multidrug resistance associated protein	0	0	0	1
histone acetyltransferase KAT2A isoform 1	4	0	0	4
Chain A, Glutamine Binding Protein	0	0	1	1
thioredoxin reductase	4	0	0	4
GLS protein	1	0	0	1
arylsulfatase A	1	0	0	1
peripheral myelin protein 22 isoform 1	1	0	0	1
flap endonuclease 1	3	0	0	3
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Amino acid transporter	0	1	0	1
ATP-dependent phosphofructokinase	1	0	0	1
Acyl-CoA desaturase 1	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Smoothened homolog	0	1	0	1
Solute carrier family 22 member 3	0	2	0	2
Solute carrier family 22 member 1	0	2	0	3
Solute carrier family 22 member 2	0	2	0	3
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
thioredoxin glutathione reductase	1	0	0	1
Smad3	3	0	0	3
nonstructural protein 1	2	0	0	2
Neuraminidase	0	1	0	1
67.9K protein	4	0	0	4
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
TPA: protein transporter TIM10	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
Vpr	2	0	0	2
high affinity choline transporter 1 isoform a	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	2
Spike glycoprotein	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	1	1
Retinoic acid receptor RXR-alpha	0	0	1	2
Cannabinoid receptor 1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
Cannabinoid receptor 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-2	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
G-protein coupled bile acid receptor 1	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Angiotensin-converting enzyme 2	0	0	1	1
Platelet glycoprotein VI	0	0	1	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	2	3
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Chain A, Beta-lactamase	2	0	0	2
GALC protein	2	0	0	2
chromobox protein homolog 1	4	0	0	4
lamin isoform A-delta10	3	0	0	3
Serum paraoxonase/arylesterase 1	0	1	0	1
Chain A, Cell Division Protein Kinase 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, Cell Division Protein Kinase 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, Cell Division Protein Kinase 2	0	1	0	1
DNA repair and recombination protein RadA	0	0	1	1
Indoleamine 2,3-dioxygenase 1	0	0	1	1
Cyclin-A1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Acetylcholinesterase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Sodium channel protein type 4 subunit alpha	0	1	0	1
Cholinesterase	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	2	0	2
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
Glutathione reductase, mitochondrial	0	2	0	2
Cationic amino acid transporter 3	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	1	2
5-hydroxytryptamine receptor 2B	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	3	2	5
acetylcholinesterase	2	0	0	2
SMAD family member 2	2	0	0	2
SMAD family member 3	2	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	1	0	0	1
Chain A, NAD-dependent deacetylase	0	1	0	1
Poly [ADP-ribose] polymerase 2	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Coagulation factor VII	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
Tissue factor	0	1	0	1
Cytochrome P450 3A5	0	1	0	1
NAD-dependent protein deacetylase HST2	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
NAD(+) hydrolase SARM1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
NAD-dependent protein deacetylase	0	1	0	1
Luciferase	1	0	0	1
Cytochrome P450 2D6	0	1	0	1
Myosin light chain kinase, smooth muscle	0	0	1	1
Acetylcholinesterase	0	4	0	4
Tubulin alpha-1A chain	0	0	1	1
Carbonic anhydrase 9	0	2	0	2
Receptor protein-tyrosine kinase	0	1	0	1
Macrophage colony-stimulating factor 1 receptor	0	1	0	1
IDH1	2	0	0	2
beta-2 adrenergic receptor	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
pregnane X receptor	1	0	0	1
phosphopantetheinyl transferase	2	0	0	2
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
DNA polymerase iota isoform a (long)	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Histamine H2 receptor	2	0	0	2
Guanine nucleotide-binding protein G	1	0	0	1
TAR DNA-binding protein 43	2	0	0	2
heat shock protein 90, putative	0	0	0	1
cytochrome P450 2D6 isoform 1	1	0	0	1
cytochrome P450 2C19 precursor	1	0	0	1
cytochrome P450 2C9 precursor	1	0	0	1
runt-related transcription factor 1 isoform AML1b	1	0	0	1
core-binding factor subunit beta isoform 2	1	0	0	1
DNA polymerase kappa isoform 1	1	0	0	1
Cholinesterase	0	2	0	2
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Inositol monophosphatase 1	1	0	0	1
Glycoprotein hormones alpha chain	1	0	0	1
Nuclear factor NF-kappa-B p105 subunit	0	1	0	2
Eukaryotic initiation factor 4A-I	0	1	1	2
Transcription factor p65	0	1	0	2
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Polyphenol oxidase 2	0	1	0	2
Carbonic anhydrase 12	0	1	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Bile salt export pump	0	1	0	1
Albumin	0	1	0	1
Polymerase acidic protein	0	0	1	1
Carbonic anhydrase 3	0	1	0	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 6	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Carbonic anhydrase 7	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
Carbonic anhydrase 14	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Exportin-1	0	0	1	1
Cholecystokinin receptor type A	0	1	0	1
Cholecystokinin receptor type A	0	2	0	2
Gastrin/cholecystokinin type B receptor	0	1	1	2
Cholecystokinin receptor type A	0	2	2	4
Mu-type opioid receptor	0	0	1	1
Delta-type opioid receptor	0	0	1	1
Gastrin/cholecystokinin type B receptor	0	2	0	2
Cholecystokinin receptor type A	0	2	0	2
Solute carrier organic anion transporter family member 1B3	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Eukaryotic translation initiation factor 4E	0	0	1	1
Cytochrome P450 2C9	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	1	0	1
Cytochrome P450 2C19	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Programmed cell death protein 4	0	0	1	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	1	0	1
Chain A, Thymidylate Synthase	0	0	1	1
Thymidylate synthase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	1
Thymidylate kinase	0	0	0	1
Thymidylate kinase	0	1	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(10)

Research Excerpts

Overview

Treatment

Research

Studies (56)

Protein Targets (889)

Malignant Neurilemmoma

Synonyms(10)

Research Excerpts

Overview

Treatment

Research

Studies (56)

Drugs Studied (56)

Protein Targets (889)