Compounds > triazoles
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triazoles and caffeine

triazoles has been researched along with caffeine in 98 studies

Research

Studies (98)

TimeframeStudies, this research(%)All Research%
pre-19902 (2.04)18.7374
1990's12 (12.24)18.2507
2000's55 (56.12)29.6817
2010's27 (27.55)24.3611
2020's2 (2.04)2.80

Authors

AuthorsStudies
Anderson, WH; Fitzpatrick, DF; Hwang, DP; Krzanowski, JJ; Polson, JB; Szentivanyi, A1
Adén, U; Fredholm, BB; Johansson, B; Lindström, K; Svenningsson, P1
Holtzman, SG1
Browne, RG; Howard, HR; Koe, BK; Lebel, LA; Sarges, R; Seymour, PA1
Collier, HO; Cuthbert, NJ; Francis, DL1
Dohi, T; Miyasako, T; Morita, K; Suemitsu, T; Uchiyama, Y1
Howell, LL1
Byrd, LD; Howell, LL1
Fenu, S; Morelli, M1
O'Regan, MH; Phillis, JW; Song, D1
Fredholm, BB; Johansson, B; Kuzmin, A; Zvartau, EE1
Fredholm, BB; Lindström, K1
Kopf, SR; Melani, A; Pedata, F; Pepeu, G1
Borgeat, P; Bourgoin, SG; Harbour, D; Naccache, PH; Thibault, N1
Costentin, J; El Yacoubi, M; Ledent, C; Parmentier, M; Vaugeois, JM2
Gean, PW; Lu, KT; Wu, SP1
Pèzzola, A; Popoli, P; Reggio, R1
Costentin, J; El Yacoubi, M; Ledent, C; Ménard, JF; Parmentier, M; Vaugeois, JM1
Belardinelli, L; Borea, PA; Gessi, S; Merighi, S; Ongini, E; Portaluppi, F; Varani, K1
Cauli, O; Fenu, S; Morelli, M1
Fredholm, BB; Halldner, L; Lindström, K; Lozza, G1
Beilstein, M; Castagnoli, K; Castagnoli, N; Chen, JF; Petzer, JP; Schwarzschild, MA; Sonsalla, PK; Staal, R; Xu, K; Xu, YH1
Hamann, M; Richter, A1
Costentin, J; El Yacoubi, M; Ledent, C; Ongini, E; Parmentier, M; Vaugeois, JM1
Acquas, E; Di Chiara, G; Tanda, G1
Anderson, KE; Daniele, N; Foukas, LC; Jensen, J; Ktori, C; Shepherd, PR1
Ferré, S; Goldberg, SR; Karcz-Kubicha, M; Popoli, P; Solinas, M; You, ZB1
Bibb, JA; Fienberg, AA; Fisone, G; Fredholm, BB; Greengard, P; Kim, Y; Lindskog, M; Nairn, AC; Pozzi, L; Svenningsson, P1
Allen, C; Christie, S; Göbel, H; Mateos, V; Shivaprakash, M; Vrijens, F1
Antoniou, K; Ferré, S; Fuxe, K; Goldberg, SR; Justinova, Z; Karcz-Kubicha, M; Müller, CE; Pezzola, A; Popoli, P; Quarta, D; Reggio, R; Solinas, M; Terasmaa, A1
Cunha, RA; Dall'Igna, OP; Dall'lgna, OP; Lara, DR; Porciúncula, LO; Souza, DO1
Berrino, L; Capuano, A; De Novellis, V; Filippelli, A; Mazzeo, F; Rossi, F; Stella, L; Vitelli, MR1
O'Regan, MH; Phillis, JW1
Brodmann, M; Lischnig, U; Lueger, A; Pilger, E; Stark, G1
Fredholm, BB; Svenningsson, P1
Gianfriddo, M; Melani, A; Pedata, F; Pugliese, AM1
Costentin, J; El Yacoubi, M; Vaugeois, JM1
Goulart, EC; Kaster, MP; Rodrigues, AL; Rosa, AO; Rosso, MM; Santos, AR1
Bremer, HC; Elsner, P; Girolomoni, G; Herouy, Y; Idzko, M; Mockenhaupt, M; Norgauer, J; Panther, E; Sorichter, S; Windisch, W1
Batista, LC; Prediger, RD; Takahashi, RN1
Connole, L; Harkin, A; Maginn, M1
Bennett, MR; Lin, YQ1
Prediger, RD; Takahashi, RN1
Fernandes, D; Prediger, RD; Takahashi, RN1
Hay, JW; Zhang, L1
Fredholm, BB; Gimenez, L; Johansson, B; Kuzmin, A; Ogren, SO1
Holý, A; Kmonícková, E; Potmesil, P; Zídek, Z1
Clarke, GD; Godfrey, L; Hourani, SM; Kitchen, I; Ledent, C; Yan, L1
Holý, A; Kmonícková, E; Krecmerová, M; Potmesil, P; Zídek, Z1
Chan, ES; Chen, JF; Cronstein, BN; Delano, DL; Desai, A; Fernandez, P; Friedman, SL; Montesinos, MC; Pillinger, MH; Reiss, AB; Schwarzschild, MA; Yee, H1
Conde, SV; Gonzalez, C; Obeso, A; Rigual, R; Rocher, A; Vicario, I1
Cunha, RA; Dall'Igna, OP; Fett, P; Gomes, MW; Lara, DR; Souza, DO1
Bairam, A; Kinkead, R; Montandon, G2
Desfrere, L; Gressens, P; Olivier, P; Schwendimann, L; Verney, C1
Binfaré, RW; Budni, J; Lobato, KR; Rodrigues, AL; Rosa, AO; Santos, AR1
Coskun, C; Mutlu, D; Savci, V; Suzer, O; Yalcin, M; Yilmaz, MS1
Jesse, CR; Nogueira, CW; Savegnago, L1
Grzelak, ME; Hodgson, RA; Hunter, JC; Parker, EM; Pond, AJ; Varty, GB1
Cormack, LK; Feinberg, LM; Schallert, K; Schallert, T; Spinetta, MJ; Stroud, C; Woodlee, MT1
Ahlawat, R; Chavez-Valdez, R; Cristofalo, EA; Gauda, EB; Nathan, A; Wills-Karp, M1
Baghdoyan, HA; Lydic, R; Van Dort, CJ1
Chen, CY; Chiu, TH; Hsu, CW; Wang, CS1
Fernandes, D; Pamplona, FA; Pandolfo, P; Pires, VA; Prediger, RD; Takahashi, RN1
Goode, T; Harris, A; Trevitt, J; Vallance, C1
Arbogast, LA; Hughes, LF; Mhaskar, Y; Toth, LA; Trammell, RA; Xie, X1
Jalali, A; Kawa, K; Larsen, C; Trevitt, J1
Agostinho, PM; Cognato, GP; Cunha, RA; Hockemeyer, J; Müller, CE; Souza, DO1
Canas, PM; Cunha, GM; Cunha, RA; Machado, NJ; Oliveira, CR; Oliveira, JM; Porciúncula, LO; Silva, CG1
Eyanagi, R; Imoto, M; Kuroki, H; Nishimura, S; Shimeno, H; Soeda, S; Toda, A; Uchiyama, H; Watanabe, S1
Boeck, CR; Calo', G; de Castro, AA; Dos Santos Casagrande, T; Gavioli, EC; Guerrini, R; Martinello, C; Moretti, M1
Chiu, TH; Hsu, CW; Wang, CS1
Brandão, R; Jesse, CR; Leite, MR; Nogueira, CW; Wilhelm, EA1
Dziubina, A; Gołembiowska, K2
Bennett, K; Congreve, M; Doré, AS; Errey, JC; Hollenstein, K; Hurrell, E; Magnani, F; Marshall, FH; Ng, I; Robertson, N; Tate, CG; Tehan, B; Weir, M1
Ayers, PW; Burger, SK; Liu, Y; Vöhringer-Martinez, E1
Azevedo, MS; Cechinel-Filho, V; Ferreira, VM; Lucena, GM; Matheus, FC; Prediger, RD; Tessele, PB1
Martins, DF; Mazzardo-Martins, L; Piovezan, AP; Santos, AR; Soldi, F; Stramosk, J1
Manian, S; Marimuthu, S; Sowndhararajan, K1
Canuti, E; Loos, R; Paracchini, B; Tavazzi, S; Weissteiner, C1
Edling, CE; Falasca, M; Ghonaim, R; Maffucci, T; Selvaggi, F1
Dubroqua, S; Singer, P; Yee, BK1
Gao, N; Guan, X; Li, J; Shen, J; Sun, B; Xiong, X; Zhang, J1
Andriolo, V; Castorina, A; Giunta, S1
Baxter, C; Edgar, DM; Gilmour, G; Kellett, DO; Loomis, S; McCarthy, A; Tricklebank, M1
Hiromura, M; Honda, S; Inoue, K; Kosako, K; Kuroki, H; Shiratani, T; Soeda, S; Toda, A; Uchiyama, H1
Chaimovitz, C; Douvdevani, A; Eini, H; Frishman, V; Kachko, L; Lewis, EC; Yulzari, R1
Akhtar, S; Desai, A; Goldwater, R; Han, D; Howieson, C; Kowalski, D; Lademacher, C; Pearlman, H; Rammelsberg, D; Townsend, R; Yamazaki, T1
Ishikawa, T; Nakamura, M; Nishiyama, R; Saito, SY; Todoroki, K; Toyo'oka, T; Yamaguchi, M1
Chowdhury, AN; Fong, R; Fox, AP; Khokhar, S; Wong, JH; Xie, KG; Xie, Z1
Bai, X; He, J; Li, T; Qiao, H; Xu, J; Ye, X; Zhang, J; Zhang, W1
Colmenero, AV; Gabel, M; Hambrecht-Wiedbusch, VS; Imperial, JP; Liu, LJ; Vanini, G1
Bajnok, A; Orbán, C; Sava, F; Toldi, G; Vásárhelyi, Z1
Gom, RC; Phillips, TJ; Teskey, GC; Wolff, MD1
Collares, FM; Cunha, RA; de Souza Balbinot, G; Lima, RR; Maia, C; Martins Ferreira, MK; Martins, MD; Pinheiro, BG; Schmidt, TR; Soares da Silva, CC; Souza-Monteiro, D1
Bharate, SB; Bhatt, S; Nandi, U; Nuthakki, VK; Sharma, A; Sharma, M1

Reviews

2 review(s) available for triazoles and caffeine

ArticleYear
Adenosine-dopamine interactions: development of a concept and some comments on therapeutic possibilities.
    Neurology, 2003, Dec-09, Volume: 61, Issue:11 Suppl 6

    Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Corpus Striatum; Dopamine; Dopamine and cAMP-Regulated Phosphoprotein 32; Humans; Mice; Nerve Tissue Proteins; Parkinson Disease; Phosphoproteins; Phosphorylation; Pyrimidines; Receptor, Adenosine A2A; Receptors, Dopamine D2; Signal Transduction; Triazoles

2003
Cost-effectiveness analysis of rizatriptan and sumatriptan versus Cafergot in the acute treatment of migraine.
    CNS drugs, 2005, Volume: 19, Issue:7

    Topics: Caffeine; Cost-Benefit Analysis; Drug Combinations; Drug Therapy, Combination; Economics, Pharmaceutical; Ergotamine; Humans; Migraine Disorders; Serotonin Receptor Agonists; Sumatriptan; Triazoles; Tryptamines

2005

Trials

2 trial(s) available for triazoles and caffeine

ArticleYear
Crossover comparison of efficacy and preference for rizatriptan 10 mg versus ergotamine/caffeine in migraine.
    European neurology, 2003, Volume: 49, Issue:1

    Topics: Adolescent; Adult; Aged; Caffeine; Cross-Over Studies; Double-Blind Method; Drug Combinations; Ergotamine; Female; Humans; Male; Middle Aged; Migraine Disorders; Pain Measurement; Patient Satisfaction; Serotonin Receptor Agonists; Triazoles; Tryptamines

2003
Pharmacokinetic Effects of Isavuconazole Coadministration With the Cytochrome P450 Enzyme Substrates Bupropion, Repaglinide, Caffeine, Dextromethorphan, and Methadone in Healthy Subjects.
    Clinical pharmacology in drug development, 2017, Volume: 6, Issue:1

    Topics: Adult; Area Under Curve; Bupropion; Caffeine; Carbamates; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Female; Healthy Volunteers; Humans; Male; Methadone; Middle Aged; Nitriles; Piperidines; Pyridines; Triazoles; Young Adult

2017

Other Studies

94 other study(ies) available for triazoles and caffeine

ArticleYear
Analysis of the relationship between pharmacological inhibition of cyclic nucleotide phosphodiesterase and relaxation of canine tracheal smooth muscle.
    Biochemical pharmacology, 1979, Apr-15, Volume: 28, Issue:8

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Airway Resistance; Animals; Caffeine; Dogs; Etazolate; Female; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Phosphodiesterase Inhibitors; Pyrazines; Theophylline; Trachea; Triazoles

1979
Evidence that the increase in striatal c-fos following acute high-dose caffeine is not due to direct interaction with striatal adenosine receptors.
    Acta physiologica Scandinavica, 1992, Volume: 146, Issue:4

    Topics: Adenosine; Animals; Caffeine; Corpus Striatum; Dose-Response Relationship, Drug; Genes, fos; Purinergic Antagonists; Quinazolines; Rats; RNA, Messenger; Triazoles; Xanthines

1992
CGS 15943, a nonxanthine adenosine receptor antagonist: effects on locomotor activity of nontolerant and caffeine-tolerant rats.
    Life sciences, 1991, Volume: 49, Issue:21

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Dose-Response Relationship, Drug; Drug Tolerance; Male; Motor Activity; Quinazolines; Rats; Rats, Inbred Strains; Triazoles

1991
4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:8

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Antidepressive Agents; Behavior, Animal; Caffeine; Cats; Cell Membrane; Cerebral Cortex; Chemical Phenomena; Chemistry; Corpus Striatum; Male; Molecular Structure; Motor Activity; Purinergic Antagonists; Quinoxalines; Rats; Receptors, Purinergic; Sleep; Structure-Activity Relationship; Triazoles

1990
Character and meaning of quasi-morphine withdrawal phenomena elicited by methylxanthines.
    Federation proceedings, 1981, Volume: 40, Issue:5

    Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Caffeine; Humans; Hypoxanthines; Morphine Dependence; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Phosphodiesterase Inhibitors; Pyrimidines; Rats; Substance Withdrawal Syndrome; Theobromine; Theophylline; Triazoles; Xanthines

1981
Platelet-activating factor mediated potentiation of stimulation-evoked catecholamine release and the rise in intracellular free Ca2+ concentration in adrenal chromaffin cells.
    Journal of lipid mediators and cell signalling, 1995, Volume: 11, Issue:3

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Adrenal Glands; Animals; Azepines; Caffeine; Calcium; Catecholamines; Cattle; Cells, Cultured; Chromaffin Granules; Dose-Response Relationship, Drug; Kinetics; Platelet Activating Factor; Platelet Membrane Glycoproteins; Potassium Chloride; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Stimulation, Chemical; Time Factors; Triazoles

1995
Comparative effects of caffeine and selective phosphodiesterase inhibitors on respiration and behavior in rhesus monkeys.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 266, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Behavior, Animal; Caffeine; Carbon Dioxide; Conditioning, Psychological; Female; Macaca mulatta; Male; Phosphodiesterase Inhibitors; Quinazolines; Respiration; Triazoles

1993
Effects of CGS 15943, a nonxanthine adenosine antagonist, on behavior in the squirrel monkey.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:1

    Topics: Animals; Behavior, Animal; Caffeine; Drug Interactions; Drug Synergism; Male; Purinergic P1 Receptor Antagonists; Pyrrolidinones; Quinazolines; Receptors, Purinergic P1; Rolipram; Saimiri; Time Factors; Triazoles

1993
Motor stimulant effects of caffeine in 6-hydroxydopamine-lesioned rats are dependent on previous stimulation of dopamine receptors: a different role of D1 and D2 receptors.
    The European journal of neuroscience, 1998, Volume: 10, Issue:5

    Topics: Animals; Apomorphine; Caffeine; Central Nervous System Stimulants; Dopamine Agonists; Male; Motor Activity; Oxidopamine; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Rotation; Stimulation, Chemical; Triazoles; Xanthines

1998
The role of adenosine in rat coronary flow regulation during respiratory and metabolic acidosis.
    European journal of pharmacology, 1998, Sep-04, Volume: 356, Issue:2-3

    Topics: Acidosis; Acidosis, Respiratory; Adenosine; Animals; Caffeine; Coronary Circulation; Hypercapnia; Male; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, Sprague-Dawley; Theophylline; Triazines; Triazoles

1998
Caffeine, acting on adenosine A(1) receptors, prevents the extinction of cocaine-seeking behavior in mice.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 290, Issue:2

    Topics: Animals; Behavior, Animal; Caffeine; Cocaine; Extinction, Psychological; Male; Mice; Mice, Inbred DBA; Purinergic P1 Receptor Antagonists; Pyrimidines; Quinazolines; Reward; Substance Abuse, Intravenous; Theophylline; Triazoles; Xanthines

1999
Autoradiographic comparison of the potency of several structurally unrelated adenosine receptor antagonists at adenosine A1 and A(2A) receptors.
    European journal of pharmacology, 1999, Sep-10, Volume: 380, Issue:2-3

    Topics: Adenosine; Animals; Autoradiography; Binding, Competitive; Brain; Caffeine; In Vitro Techniques; Male; Phenethylamines; Purinergic P1 Receptor Antagonists; Pyrazines; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Purinergic P1; Theophylline; Triazines; Triazoles; Tritium; Xanthines

1999
Adenosine and memory storage: effect of A(1) and A(2) receptor antagonists.
    Psychopharmacology, 1999, Volume: 146, Issue:2

    Topics: Adenosine; Animals; Avoidance Learning; Caffeine; Central Nervous System Stimulants; Male; Memory; Mice; Purinergic P1 Receptor Antagonists; Pyrimidines; Triazoles; Xanthines

1999
Adenosine receptor occupancy suppresses chemoattractant-induced phospholipase D activity by diminishing membrane recruitment of small GTPases.
    Blood, 2000, Jan-15, Volume: 95, Issue:2

    Topics: Adenosine; Adenosine Deaminase; Adenosine-5'-(N-ethylcarboxamide); ADP-Ribosylation Factor 1; Adult; Caffeine; Cell Membrane; Enzyme Activation; GTP Phosphohydrolases; Humans; In Vitro Techniques; Isoenzymes; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phenethylamines; Phospholipase D; Protein Kinase C; Protein Kinase C-alpha; Purinergic P1 Receptor Antagonists; Quinazolines; Receptor, Adenosine A2A; Receptors, Purinergic P1; rhoA GTP-Binding Protein; Triazoles

2000
The anxiogenic-like effect of caffeine in two experimental procedures measuring anxiety in the mouse is not shared by selective A(2A) adenosine receptor antagonists.
    Psychopharmacology, 2000, Volume: 148, Issue:2

    Topics: Adenosine; Administration, Oral; Animals; Anxiety; Behavior, Animal; Caffeine; Darkness; Drug Administration Schedule; Injections, Intraperitoneal; Light; Male; Maze Learning; Mice; Mice, Knockout; Neuroprotective Agents; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrimidines; Reaction Time; Receptor, Adenosine A2A; Triazines; Triazoles; Xanthines

2000
Promotion of forskolin-induced long-term potentiation of synaptic transmission by caffeine in area CA1 of the rat hippocampus.
    The Chinese journal of physiology, 1999, Dec-31, Volume: 42, Issue:4

    Topics: Adenosine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Central Nervous System Stimulants; Colforsin; Cyclic AMP; Drug Synergism; Excitatory Postsynaptic Potentials; Hippocampus; Long-Term Potentiation; Male; Quinazolines; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Triazoles; Xanthines

1999
Effects of SCH 58261, an adenosine A(2A) receptor antagonist, on quinpirole-induced turning in 6-hydroxydopamine-lesioned rats. Lack of tolerance after chronic caffeine intake.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2000, Volume: 22, Issue:5

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; Male; Motor Activity; Neuroprotective Agents; Parkinson Disease; Purinergic P1 Receptor Antagonists; Pyrimidines; Quinpirole; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Time Factors; Triazoles

2000
The stimulant effects of caffeine on locomotor behaviour in mice are mediated through its blockade of adenosine A(2A) receptors.
    British journal of pharmacology, 2000, Volume: 129, Issue:7

    Topics: Analysis of Variance; Animals; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Habituation, Psychophysiologic; Male; Mice; Mice, Knockout; Motor Activity; Purinergic P1 Receptor Antagonists; Pyrimidines; Receptor, Adenosine A2A; Receptors, Purinergic P1; Triazoles; Xanthines

2000
Dose and time effects of caffeine intake on human platelet adenosine A(2A) receptors : functional and biochemical aspects.
    Circulation, 2000, Jul-18, Volume: 102, Issue:3

    Topics: Adenosine-5'-(N-ethylcarboxamide); Adult; Blood Platelets; Caffeine; Calcium; Cyclic AMP; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Myocardium; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P1 Receptor Agonists; Pyrimidines; Receptor, Adenosine A2A; Receptors, Purinergic P1; Time Factors; Triazoles; Up-Regulation

2000
Cross-sensitization between the motor activating effects of bromocriptine and caffeine: role of adenosine A(2A) receptors.
    Behavioural brain research, 2000, Volume: 114, Issue:1-2

    Topics: Animals; Bromocriptine; Caffeine; Central Nervous System Stimulants; Dopamine Agonists; Dose-Response Relationship, Drug; Male; Motor Activity; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Purinergic P1; Stereotyped Behavior; Stimulation, Chemical; Triazoles

2000
Lack of tolerance to motor stimulant effects of a selective adenosine A(2A) receptor antagonist.
    European journal of pharmacology, 2000, Oct-20, Volume: 406, Issue:3

    Topics: Animals; Apomorphine; Caffeine; Drug Tolerance; Genes, Immediate-Early; Male; Motor Activity; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Purinergic P1; RNA, Messenger; Triazoles

2000
Neuroprotection by caffeine and A(2A) adenosine receptor inactivation in a model of Parkinson's disease.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, May-15, Volume: 21, Issue:10

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Caffeine; Catechols; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Immunity, Innate; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuroprotective Agents; Parkinsonian Disorders; Purinergic P1 Receptor Antagonists; Purines; Pyrimidines; Receptor, Adenosine A2A; Receptors, Purinergic P1; Theobromine; Triazoles; Xanthines

2001
Effects of adenosine receptor agonists and antagonists in a genetic animal model of primary paroxysmal dystonia.
    British journal of pharmacology, 2001, Volume: 134, Issue:2

    Topics: Adenosine; Animals; Caffeine; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Dystonia; Female; Male; Mesocricetus; Muscle Contraction; Mutation; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Theobromine; Theophylline; Triazines; Triazoles; Xanthines

2001
In vivo labelling of the adenosine A2A receptor in mouse brain using the selective antagonist [3H]SCH 58261.
    The European journal of neuroscience, 2001, Volume: 14, Issue:9

    Topics: Adenosine; Animals; Binding Sites; Binding, Competitive; Blood-Brain Barrier; Brain; Caffeine; Dose-Response Relationship, Drug; Drug Interactions; Male; Mice; Mice, Knockout; Neurons; Neuroprotective Agents; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Antagonists; Pyrimidines; Radioligand Assay; Receptor, Adenosine A2A; Receptors, Purinergic P1; Triazoles; Tritium

2001
Differential effects of caffeine on dopamine and acetylcholine transmission in brain areas of drug-naive and caffeine-pretreated rats.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2002, Volume: 27, Issue:2

    Topics: Acetylcholine; Animals; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Dopamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Extracellular Space; Injections, Intraperitoneal; Male; Microdialysis; Neuroprotective Agents; Nucleus Accumbens; Prefrontal Cortex; Presynaptic Terminals; Pyrimidines; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Triazoles; Xanthines

2002
Direct effects of caffeine and theophylline on p110 delta and other phosphoinositide 3-kinases. Differential effects on lipid kinase and protein kinase activities.
    The Journal of biological chemistry, 2002, Oct-04, Volume: 277, Issue:40

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Biological Transport; Caffeine; CHO Cells; Cricetinae; Deoxyglucose; Dimerization; Flavins; Glucose; Kinetics; Monosaccharide Transport Proteins; Phosphatidylinositol 3-Kinases; Phosphorylation; Quinazolines; Recombinant Fusion Proteins; Theophylline; Transfection; Triazoles

2002
Caffeine induces dopamine and glutamate release in the shell of the nucleus accumbens.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Aug-01, Volume: 22, Issue:15

    Topics: Animals; Behavior, Animal; Caffeine; Dopamine; Dose-Response Relationship, Drug; Extracellular Space; Glutamic Acid; Injections, Intraperitoneal; Male; Microdialysis; Motor Activity; Nucleus Accumbens; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Theophylline; Triazoles; Wakefulness

2002
Involvement of DARPP-32 phosphorylation in the stimulant action of caffeine.
    Nature, 2002, Aug-15, Volume: 418, Issue:6899

    Topics: Adenosine; Animals; Caffeine; Central Nervous System Stimulants; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Dopamine and cAMP-Regulated Phosphoprotein 32; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Neostriatum; Nerve Tissue Proteins; Neurons; Phenethylamines; Phosphoproteins; Phosphorylation; Phosphothreonine; Purinergic P1 Receptor Antagonists; Pyrimidines; Receptors, Purinergic P1; Triazoles

2002
Involvement of adenosine A1 and A2A receptors in the motor effects of caffeine after its acute and chronic administration.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2003, Volume: 28, Issue:7

    Topics: Adenosine; Amphetamine; Animals; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Male; Motor Activity; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Purinergic P1; Theophylline; Time Factors; Triazines; Triazoles; Tritium; Xanthines

2003
Neuroprotection by caffeine and adenosine A2A receptor blockade of beta-amyloid neurotoxicity.
    British journal of pharmacology, 2003, Volume: 138, Issue:7

    Topics: Adenosine A2 Receptor Antagonists; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Caffeine; Cells, Cultured; Central Nervous System Diseases; Cerebellum; Neurons; Neuroprotective Agents; Peptide Fragments; Rats; Rats, Wistar; Receptor, Adenosine A2A; Theophylline; Triazines; Triazoles

2003
Interactive role of adenosine and dopamine in the opiate withdrawal syndrome.
    Naunyn-Schmiedeberg's archives of pharmacology, 2003, Volume: 368, Issue:2

    Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Chromatography, High Pressure Liquid; Dopamine; Injections, Subcutaneous; Male; Microdialysis; Morphine; Pyrimidines; Rats; Rats, Wistar; Receptors, Dopamine; Substance Withdrawal Syndrome; Triazoles

2003
Effects of adenosine receptor antagonists on pial arteriolar dilation during carbon dioxide inhalation.
    European journal of pharmacology, 2003, Aug-29, Volume: 476, Issue:3

    Topics: Adenosine; Administration, Inhalation; Animals; Caffeine; Carbon Dioxide; Cerebral Cortex; Cerebral Veins; Cerebrovascular Circulation; Drug Interactions; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Purinergic P1 Receptor Antagonists; Quinazolines; Rats; Rats, Sprague-Dawley; Triazines; Triazoles; Vasodilation; Vasodilator Agents; Xanthines

2003
The effect of caffeine on peripheral vascular resistance in isolated perfused guinea pig hind limbs.
    Journal of cardiovascular pharmacology, 2003, Volume: 42, Issue:4

    Topics: Adenosine; Animals; Caffeine; Dose-Response Relationship, Drug; Female; Flavins; Guinea Pigs; Hindlimb; Hypoxia; Iliac Artery; Iloprost; Male; Nitrogen; Norepinephrine; Perfusion; Triazines; Triazoles; Vascular Resistance; Vasoconstriction; Vasodilation

2003
Caffeine reduces hypnotic effects of alcohol through adenosine A2A receptor blockade.
    Neuropharmacology, 2003, Volume: 45, Issue:7

    Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Body Temperature; Caffeine; Central Nervous System Depressants; Central Nervous System Stimulants; Dipyridamole; Drug Overdose; Ethanol; Hypnotics and Sedatives; Male; Mice; Mice, Knockout; Neuroprotective Agents; Pentobarbital; Postural Balance; Pyrimidines; Receptor, Adenosine A2A; Triazoles; Vasodilator Agents; Xanthines

2003
A2A receptors in neuroprotection of dopaminergic neurons.
    Neurology, 2003, Dec-09, Volume: 61, Issue:11 Suppl 6

    Topics: Adenosine A2 Receptor Antagonists; Animals; Caffeine; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Male; Neurons; Neuroprotective Agents; Parkinson Disease; Purines; Pyrimidines; Receptor, Adenosine A2A; Sex Factors; Triazoles

2003
Adenosine A2A receptors and depression.
    Neurology, 2003, Dec-09, Volume: 61, Issue:11 Suppl 6

    Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Antidepressive Agents; Behavior, Animal; Caffeine; Depression; Disease Models, Animal; Dopamine Antagonists; Drug Interactions; Haloperidol; Mice; Mice, Knockout; Motor Activity; Neurotransmitter Agents; Parkinsonian Disorders; Purines; Pyrimidines; Receptor, Adenosine A2A; Triazines; Triazoles

2003
Adenosine administration produces an antidepressant-like effect in mice: evidence for the involvement of A1 and A2A receptors.
    Neuroscience letters, 2004, Jan-23, Volume: 355, Issue:1-2

    Topics: Adenosine; Animals; Antidepressive Agents; Caffeine; Depressive Disorder; Disease Models, Animal; Female; Male; Mice; Motor Activity; Receptor, Adenosine A1; Receptor, Adenosine A2A; Stress, Psychological; Triazines; Triazoles; Xanthines

2004
Inosine stimulates chemotaxis, Ca2+-transients and actin polymerization in immature human dendritic cells via a pertussis toxin-sensitive mechanism independent of adenosine receptors.
    Journal of cellular physiology, 2004, Volume: 199, Issue:1

    Topics: Actins; Antigens, CD; Caffeine; Calcium; Cell Differentiation; Chemotaxis; Cytokines; Dendritic Cells; Dose-Response Relationship, Drug; Flow Cytometry; Histocompatibility Antigens Class I; Humans; Inosine; Pertussis Toxin; Purinergic P1 Receptor Antagonists; Quinazolines; Receptors, Purinergic P1; Triazoles; Xanthines

2004
Adenosine A1 receptors modulate the anxiolytic-like effect of ethanol in the elevated plus-maze in mice.
    European journal of pharmacology, 2004, Sep-19, Volume: 499, Issue:1-2

    Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Caffeine; Dose-Response Relationship, Drug; Drug Synergism; Ethanol; Male; Maze Learning; Mice; Receptor, Adenosine A1; Triazines; Triazoles; Xanthines

2004
Adenosine A1 receptor blockade mimics caffeine's attenuation of ethanol-induced motor incoordination.
    Basic & clinical pharmacology & toxicology, 2004, Volume: 95, Issue:6

    Topics: Adenosine A1 Receptor Antagonists; Animals; Caffeine; Central Nervous System Depressants; Drug Interactions; Ethanol; Male; Motor Skills; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, Sprague-Dawley; Triazoles; Xanthines

2004
Varicosity-Schwann cell interactions mediated by ATP in the mouse vas deferens.
    Journal of neurophysiology, 2005, Volume: 93, Issue:5

    Topics: Adenosine Triphosphate; Adrenergic Fibers; Aniline Compounds; Animals; Caffeine; Calcium; Cell Count; Drug Interactions; Electric Stimulation; Estrenes; Evoked Potentials; Fluorescent Dyes; Immunohistochemistry; In Vitro Techniques; Male; Mice; Mice, Inbred BALB C; Organic Chemicals; Phosphodiesterase Inhibitors; Platelet Aggregation Inhibitors; Pyridoxal Phosphate; Pyrrolidinones; Quinazolines; S100 Proteins; Schwann Cells; Suramin; Time Factors; Triazoles; Uridine Triphosphate; Vas Deferens; Xanthenes

2005
Modulation of short-term social memory in rats by adenosine A1 and A(2A) receptors.
    Neuroscience letters, 2005, Mar-16, Volume: 376, Issue:3

    Topics: Adenosine; Animals; Behavior, Animal; Brain; Caffeine; Dose-Response Relationship, Drug; Drug Administration Schedule; Injections, Intraperitoneal; Male; Memory, Short-Term; Rats; Rats, Wistar; Receptor, Adenosine A1; Receptor, Adenosine A2A; Social Behavior; Triazines; Triazoles; Xanthines

2005
Blockade of adenosine A2A receptors reverses short-term social memory impairments in spontaneously hypertensive rats.
    Behavioural brain research, 2005, Apr-30, Volume: 159, Issue:2

    Topics: Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Caffeine; Discrimination Learning; Habituation, Psychophysiologic; Male; Memory Disorders; Memory, Short-Term; Rats; Rats, Inbred SHR; Rats, Wistar; Receptor, Adenosine A2A; Recognition, Psychology; Smell; Social Behavior; Social Environment; Species Specificity; Triazines; Triazoles; Xanthines

2005
Combination of adenosine A1 and A2A receptor blocking agents induces caffeine-like locomotor stimulation in mice.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2006, Volume: 16, Issue:2

    Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Brain Chemistry; Caffeine; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Early Growth Response Protein 1; In Situ Hybridization; Male; Mice; Mice, Inbred C57BL; Motor Activity; Neuroprotective Agents; Pyrimidines; RNA, Messenger; Triazoles; Xanthines

2006
Purine P1 receptor-dependent immunostimulatory effects of antiviral acyclic analogues of adenine and 2,6-diaminopurine.
    European journal of pharmacology, 2006, Jan-13, Volume: 530, Issue:1-2

    Topics: 2-Aminopurine; Adenine; Adjuvants, Immunologic; Animals; Anti-HIV Agents; Caffeine; Cell Survival; Cells, Cultured; Chemokine CCL3; Chemokine CCL4; Chemokine CCL5; Dihydropyridines; Dose-Response Relationship, Drug; Female; Flavins; Humans; Interleukin-10; Lipopolysaccharides; Macrophage Inflammatory Proteins; Macrophages; Mice; Mice, Inbred C57BL; Molecular Structure; Organophosphonates; Purinergic P1 Receptor Antagonists; Quinazolines; Receptors, Purinergic P1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Theophylline; Triazoles; Tumor Necrosis Factor-alpha

2006
Modulation of paracetamol antinociception by caffeine and by selective adenosine A2 receptor antagonists in mice.
    European journal of pharmacology, 2006, Feb-15, Volume: 531, Issue:1-3

    Topics: Acetaminophen; Adenosine A2 Receptor Antagonists; Analgesics, Non-Narcotic; Animals; Caffeine; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Female; Male; Mice; Mice, Knockout; Neuroprotective Agents; Nociceptors; Pain; Pain Measurement; Pyrimidines; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Sulfonic Acids; Time Factors; Triazoles; Xanthines

2006
Nucleotide analogues with immunobiological properties: 9-[2-Hydroxy-3-(phosphonomethoxy)propyl]-adenine (HPMPA), -2,6-diaminopurine (HPMPDAP), and their N6-substituted derivatives.
    European journal of pharmacology, 2006, Jul-01, Volume: 540, Issue:1-3

    Topics: Adenine; Animals; Caffeine; Cell Survival; Cytokines; Dihydropyridines; Dose-Response Relationship, Drug; Female; Gene Expression; Interferon-gamma; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Molecular Structure; Nitric Oxide; Nitric Oxide Synthase Type II; Nucleotides; Organophosphonates; Organophosphorus Compounds; Purinergic P1 Receptor Antagonists; Quinazolines; Receptors, Purinergic P1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Triazoles

2006
Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosis.
    British journal of pharmacology, 2006, Volume: 148, Issue:8

    Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Blotting, Western; Caffeine; Carbon Tetrachloride; Cell Line; Chromatography, High Pressure Liquid; Ethanol; Hepatocytes; Humans; Liver Cirrhosis; Matrix Metalloproteinases, Membrane-Associated; Methotrexate; Mice; Mice, Inbred C57BL; Rats; Receptor, Adenosine A2A; Reverse Transcriptase Polymerase Chain Reaction; Thioacetamide; Triazines; Triazoles

2006
Caffeine inhibition of rat carotid body chemoreceptors is mediated by A2A and A2B adenosine receptors.
    Journal of neurochemistry, 2006, Volume: 98, Issue:2

    Topics: Adenosine; Animals; Caffeine; Carotid Body; Catecholamines; Central Nervous System Stimulants; Chemoreceptor Cells; Dose-Response Relationship, Drug; Female; Hypoxia; Immunohistochemistry; Male; Potassium; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Receptors, Presynaptic; Respiratory Mechanics; Triazines; Triazoles; Xanthines

2006
Caffeine and adenosine A(2a) receptor antagonists prevent beta-amyloid (25-35)-induced cognitive deficits in mice.
    Experimental neurology, 2007, Volume: 203, Issue:1

    Topics: Adenosine A2 Receptor Antagonists; Alzheimer Disease; Amnesia; Amyloid beta-Peptides; Animals; Avoidance Learning; Brain; Caffeine; Cognition Disorders; Disease Models, Animal; Drug Synergism; Male; Maze Learning; Mice; Neuroprotective Agents; Peptide Fragments; Phosphodiesterase Inhibitors; Pyrimidines; Receptor, Adenosine A2A; Treatment Outcome; Triazoles

2007
Disruption of adenosinergic modulation of ventilation at rest and during hypercapnia by neonatal caffeine in young rats: role of adenosine A(1) and A(2A) receptors.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2007, Volume: 292, Issue:4

    Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Central Nervous System Stimulants; Hypercapnia; Injections, Intraperitoneal; Male; Plethysmography; Pulmonary Ventilation; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptor, Adenosine A2A; Rest; Time Factors; Triazines; Triazoles; Xanthines

2007
Transient inhibition of astrocytogenesis in developing mouse brain following postnatal caffeine exposure.
    Pediatric research, 2007, Volume: 62, Issue:5

    Topics: Adenosine; Animals; Animals, Newborn; Apoptosis; Astrocytes; Behavior, Animal; Body Weight; Brain; Caffeine; Cell Differentiation; Cell Proliferation; Dose-Response Relationship, Drug; Glial Fibrillary Acidic Protein; Immunohistochemistry; Injections, Intraperitoneal; Mice; Microtubule-Associated Proteins; Models, Animal; Nerve Growth Factors; Organ Size; Phenethylamines; Pyrimidines; Receptor, Adenosine A2A; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Synaptophysin; Time Factors; Triazoles

2007
Involvement of the adenosine A1 and A2A receptors in the antidepressant-like effect of zinc in the forced swimming test.
    Progress in neuro-psychopharmacology & biological psychiatry, 2008, May-15, Volume: 32, Issue:4

    Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Aniline Compounds; Animals; Antidepressive Agents; Caffeine; Central Nervous System Stimulants; Dipyridamole; Female; Male; Mice; Motor Activity; Nucleoside Transport Proteins; Receptor, Adenosine A1; Receptor, Adenosine A2A; Swimming; Triazines; Triazoles; Xanthines; Zinc

2008
Hypotensive effects of intravenously administered uridine and cytidine in conscious rats: involvement of adenosine receptors.
    European journal of pharmacology, 2008, Apr-14, Volume: 584, Issue:1

    Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Animals; Antihypertensive Agents; Blood Pressure; Caffeine; Carotid Arteries; Consciousness; Cytidine; Dose-Response Relationship, Drug; Heart Rate; Hypotension; Injections, Intravenous; Injections, Intraventricular; Male; Rats; Rats, Wistar; Receptor, Adenosine A1; Receptor, Adenosine A2A; Theobromine; Theophylline; Time Factors; Triazines; Triazoles; Uridine; Ventricular Function, Left; Ventricular Pressure; Xanthines

2008
Caffeine and a selective adenosine A(2B) receptor antagonist but not imidazoline receptor antagonists modulate antinociception induced by diphenyl diselenide in mice.
    Neuroscience letters, 2008, May-09, Volume: 436, Issue:2

    Topics: Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Benzene Derivatives; Benzofurans; Caffeine; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Imidazoles; Injections, Intraperitoneal; Male; Mice; Neuroprotective Agents; Organoselenium Compounds; Pain Measurement; Phosphodiesterase Inhibitors; Pyrimidines; Triazoles; Xanthines

2008
The effects of adenosine A2A receptor antagonists on haloperidol-induced movement disorders in primates.
    Psychopharmacology, 2008, Volume: 200, Issue:3

    Topics: Adenosine A2 Receptor Antagonists; Animals; Antipsychotic Agents; Caffeine; Catalepsy; Cebus; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; gamma-Aminobutyric Acid; Globus Pallidus; Haloperidol; Neurologic Examination; Purines; Pyrimidines; Receptor, Adenosine A2A; Saimiri; Triazoles; Xanthines

2008
Neonatal caffeine induces sex-specific developmental plasticity of the hypoxic respiratory chemoreflex in adult rats.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2008, Volume: 295, Issue:3

    Topics: Adrenergic alpha-2 Receptor Antagonists; Anesthesia; Animals; Animals, Newborn; Caffeine; Carotid Body; Central Nervous System Stimulants; Female; Gene Expression; Hypoxia; Male; Neural Inhibition; Phrenic Nerve; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Dopamine D2; Reflex; Respiration; RNA, Messenger; Sex Characteristics; Triazines; Triazoles; Tyrosine 3-Monooxygenase

2008
Alcohol-induced retrograde memory impairment in rats: prevention by caffeine.
    Psychopharmacology, 2008, Volume: 201, Issue:3

    Topics: Adenosine A2 Receptor Antagonists; Amnesia, Retrograde; Animals; Caffeine; Central Nervous System Depressants; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Drug Therapy, Combination; Ethanol; Exploratory Behavior; Habituation, Psychophysiologic; Injections, Intraperitoneal; Male; Odorants; Pentylenetetrazole; Phosphodiesterase 5 Inhibitors; Purinones; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Recognition, Psychology; Seizures; Smell; Time Factors; Triazines; Triazoles; Wood

2008
Caffeine modulates TNF-alpha production by cord blood monocytes: the role of adenosine receptors.
    Pediatric research, 2009, Volume: 65, Issue:2

    Topics: Acetamides; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Adenosine A3 Receptor Antagonists; Adult; Blotting, Western; Caffeine; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Fetal Blood; Humans; Infant, Newborn; Interleukins; Lipopolysaccharides; Middle Aged; Monocytes; Purines; Quinazolines; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Receptor, Adenosine A3; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Triazines; Triazoles; Tumor Necrosis Factor-alpha; Xanthines

2009
Adenosine A(1) and A(2A) receptors in mouse prefrontal cortex modulate acetylcholine release and behavioral arousal.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, Jan-21, Volume: 29, Issue:3

    Topics: Acetylcholine; Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Arousal; Behavior, Animal; Caffeine; Chromatography, High Pressure Liquid; Electroencephalography; Electromyography; Male; Mice; Microdialysis; Phenethylamines; Phosphodiesterase Inhibitors; Prefrontal Cortex; Receptor, Adenosine A1; Receptors, Adenosine A2; Spectrum Analysis; Triazines; Triazoles; Xanthines

2009
Caffeine and a selective adenosine A2A receptor antagonist induce reward and sensitization behavior associated with increased phospho-Thr75-DARPP-32 in mice.
    Psychopharmacology, 2009, Volume: 204, Issue:2

    Topics: Adenosine A2 Receptor Antagonists; Animals; Blotting, Western; Caffeine; Conditioning, Operant; Dopamine and cAMP-Regulated Phosphoprotein 32; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Antagonists; Pyrimidines; Reward; Triazoles; Xanthines

2009
Adenosine receptor antagonists improve short-term object-recognition ability of spontaneously hypertensive rats: a rodent model of attention-deficit hyperactivity disorder.
    Behavioural pharmacology, 2009, Volume: 20, Issue:2

    Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Attention Deficit Disorder with Hyperactivity; Blood Pressure; Caffeine; Disease Models, Animal; Female; Male; Memory, Short-Term; Methylphenidate; Rats; Rats, Inbred SHR; Rats, Wistar; Receptor, Adenosine A1; Receptors, Adenosine A2; Recognition, Psychology; Triazines; Triazoles; Xanthines

2009
Adenosine antagonists reverse the cataleptic effects of haloperidol: implications for the treatment of Parkinson's disease.
    Pharmacology, biochemistry, and behavior, 2009, Volume: 92, Issue:3

    Topics: Animals; Caffeine; Catalepsy; Dose-Response Relationship, Drug; Haloperidol; Male; Parkinson Disease; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, Sprague-Dawley; Triazoles

2009
Adenosine receptor antagonists and behavioral activation in NF-kappaB p50 subunit knockout mice.
    Life sciences, 2009, Jul-31, Volume: 85, Issue:5-6

    Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Administration, Oral; Animals; Behavior, Animal; Brain; Caffeine; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Dopamine; Enzyme Inhibitors; Injections, Intraperitoneal; Mice; Mice, Knockout; Motor Activity; Neuroprotective Agents; NF-kappa B p50 Subunit; Pyrimidines; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptors, Dopamine D2; Triazoles

2009
Differential effects of adenosine antagonists in two models of parkinsonian tremor.
    Pharmacology, biochemistry, and behavior, 2009, Volume: 94, Issue:1

    Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Cholinergic Agonists; Disease Models, Animal; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Drug Synergism; Jaw; Male; Parkinsonian Disorders; Pimozide; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, Sprague-Dawley; Tacrine; Theophylline; Tremor; Triazoles

2009
Caffeine and an adenosine A(2A) receptor antagonist prevent memory impairment and synaptotoxicity in adult rats triggered by a convulsive episode in early life.
    Journal of neurochemistry, 2010, Volume: 112, Issue:2

    Topics: Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Animals, Newborn; Caffeine; Disease Models, Animal; Disease Progression; Drug Administration Schedule; Glial Fibrillary Acidic Protein; Kainic Acid; Memory Disorders; Neurotoxicity Syndromes; Phosphodiesterase Inhibitors; Purines; Pyrimidines; Qa-SNARE Proteins; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures; Synapses; Synaptophysin; Synaptosomal-Associated Protein 25; Triazoles; Tritium; Xanthines

2010
Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by beta-amyloid peptides via p38 mitogen-activated protein kinase pathway.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, Nov-25, Volume: 29, Issue:47

    Topics: Adenosine A2 Receptor Antagonists; Alzheimer Disease; Amyloid beta-Peptides; Animals; Caffeine; Cell Survival; Cells, Cultured; Down-Regulation; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Degeneration; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Phosphodiesterase Inhibitors; Phosphorylation; Presynaptic Terminals; Pyrimidines; Rats; Rats, Wistar; Receptor, Adenosine A2A; Synaptic Membranes; Triazoles

2009
The stimulatory effects of caffeine with oseltamivir (Tamiflu) on light-dark behavior and open-field behavior in mice.
    Neuroscience letters, 2010, Jan-22, Volume: 469, Issue:2

    Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Antiviral Agents; Caffeine; Darkness; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Exploratory Behavior; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Haloperidol; Male; Mice; Motor Activity; Neurotransmitter Agents; Oseltamivir; Pyrimidines; Random Allocation; Triazoles; Xanthines

2010
Blockade of adenosine A2A receptor counteracts neuropeptide-S-induced hyperlocomotion in mice.
    Naunyn-Schmiedeberg's archives of pharmacology, 2010, Volume: 381, Issue:2

    Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Humans; Male; Mice; Mice, Inbred Strains; Motor Activity; Neuropeptides; Triazines; Triazoles

2010
Caffeine and a selective adenosine A2A receptor antagonist induce sensitization and cross-sensitization behavior associated with increased striatal dopamine in mice.
    Journal of biomedical science, 2010, Jan-15, Volume: 17

    Topics: 3,4-Dihydroxyphenylacetic Acid; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Dopamine; Homovanillic Acid; Male; Mice; Mice, Inbred BALB C; Neostriatum; Neuroprotective Agents; Phosphorylation; Pyrimidines; Serine; Triazoles; Tyrosine 3-Monooxygenase; Xanthines

2010
Protective effect of caffeine and a selective A2A receptor antagonist on impairment of memory and oxidative stress of aged rats.
    Experimental gerontology, 2011, Volume: 46, Issue:4

    Topics: Adenosine A2 Receptor Antagonists; Aging; Animals; Ascorbic Acid; Brain; Caffeine; Male; Memory; Memory Disorders; Oxidative Stress; Pyrimidines; Rats; Rats, Wistar; Reactive Nitrogen Species; Reactive Oxygen Species; Sodium-Potassium-Exchanging ATPase; Triazoles

2011
Effect of adenosine A(2A) receptor antagonists and L-DOPA on hydroxyl radical, glutamate and dopamine in the striatum of 6-OHDA-treated rats.
    Neurotoxicity research, 2012, Volume: 21, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Adenosine A2 Receptor Antagonists; Animals; Benserazide; Caffeine; Dopamine; Glutamic Acid; Hydroxyl Radical; Levodopa; Male; Microdialysis; Neostriatum; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; Receptor, Adenosine A2A; Triazines; Triazoles

2012
Structure of the adenosine A(2A) receptor in complex with ZM241385 and the xanthines XAC and caffeine.
    Structure (London, England : 1993), 2011, Sep-07, Volume: 19, Issue:9

    Topics: Adenosine A2 Receptor Agonists; Amino Acid Motifs; Amino Acid Sequence; Amino Acid Substitution; Binding Sites; Caffeine; Crystallography, X-Ray; HEK293 Cells; Humans; Hydrogen Bonding; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Binding; Protein Stability; Protein Structure, Tertiary; Receptor, Adenosine A2A; Surface Properties; Triazines; Triazoles; Xanthines

2011
Computational study of the binding modes of caffeine to the adenosine A2A receptor.
    The journal of physical chemistry. B, 2011, Dec-01, Volume: 115, Issue:47

    Topics: Amino Acid Substitution; Caffeine; Entropy; Humans; Lipid Bilayers; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Protein Binding; Protein Structure, Tertiary; Receptor, Adenosine A2A; Triazines; Triazoles

2011
The effect of adenosine A(2A) receptor antagonists on hydroxyl radical, dopamine, and glutamate in the striatum of rats with altered function of VMAT2.
    Neurotoxicity research, 2012, Volume: 22, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Adenosine A2 Receptor Antagonists; Adrenergic Uptake Inhibitors; Animals; Caffeine; Corpus Striatum; Dopamine; Dopamine Agents; Extracellular Space; Glutamic Acid; Homovanillic Acid; Hydroxyl Radical; Levodopa; Male; Microdialysis; Oxidative Stress; Rats; Rats, Wistar; Reserpine; Triazines; Triazoles; Vesicular Monoamine Transport Proteins

2012
Effects of ethanolic extract and naphthoquinones obtained from the bulbs of Cipura paludosa on short-term and long-term memory: involvement of adenosine A₁ and A₂A receptors.
    Basic & clinical pharmacology & toxicology, 2013, Volume: 112, Issue:4

    Topics: Animals; Avoidance Learning; Brazil; Caffeine; Ethanol; Furans; Iridaceae; Male; Memory, Long-Term; Memory, Short-Term; Mice; Naphthoquinones; Plant Extracts; Plant Roots; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptor, Adenosine A1; Receptors, Adenosine A2; Triazines; Triazoles; Xanthines

2013
High-intensity swimming exercise reduces neuropathic pain in an animal model of complex regional pain syndrome type I: evidence for a role of the adenosinergic system.
    Neuroscience, 2013, Mar-27, Volume: 234

    Topics: Adenine; Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Adenosine Deaminase Inhibitors; Animals; Caffeine; Exercise Therapy; Hyperalgesia; Male; Mice; Naloxone; Narcotic Antagonists; Neuralgia; Neurons; Reflex Sympathetic Dystrophy; Swimming; Triazines; Triazoles; Xanthines

2013
Integrated control of blister blight disease in tea using the biocontrol agent Ochrobactrum anthropi strain BMO-111 with chemical fungicides.
    Journal of applied microbiology, 2013, Volume: 114, Issue:5

    Topics: Animals; Basidiomycota; Biological Control Agents; Caffeine; Camellia sinensis; Catechin; Copper; Fungicides, Industrial; India; Male; Mice; Ochrobactrum anthropi; Phenols; Plant Diseases; Plant Leaves; Triazoles

2013
Analysis of polar organic contaminants in surface water of the northern Adriatic Sea by solid-phase extraction followed by ultrahigh-pressure liquid chromatography-QTRAP® MS using a hybrid triple-quadrupole linear ion trap instrument.
    Analytical and bioanalytical chemistry, 2013, Volume: 405, Issue:18

    Topics: Caffeine; Chromatography, High Pressure Liquid; Equipment Design; North Sea; Oceans and Seas; Organic Chemicals; Pesticides; Pharmaceutical Preparations; Seasons; Seawater; Solid Phase Extraction; Sucrose; Triazoles; Water Pollutants, Chemical

2013
Caffeine and the analog CGS 15943 inhibit cancer cell growth by targeting the phosphoinositide 3-kinase/Akt pathway.
    Cancer biology & therapy, 2014, Volume: 15, Issue:5

    Topics: Antineoplastic Agents; Apoptosis; Caffeine; Carcinoma, Hepatocellular; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Humans; Liver Neoplasms; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Purinergic P1 Receptor Agonists; Quinazolines; Signal Transduction; Triazoles

2014
Sensorimotor gating is disrupted by acute but not chronic systemic exposure to caffeine in mice.
    Psychopharmacology, 2014, Volume: 231, Issue:21

    Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Central Nervous System Stimulants; Male; Mice; Mice, Inbred C57BL; Prepulse Inhibition; Purinergic P1 Receptor Antagonists; Pyrimidines; Sensory Gating; Triazoles; Xanthines

2014
Activating persulfate by Fe⁰ coupling with weak magnetic field: performance and mechanism.
    Water research, 2014, Oct-01, Volume: 62

    Topics: Azo Compounds; Caffeine; Color; Diuron; Hydrogen-Ion Concentration; Iron; Kinetics; Magnetic Fields; Minerals; Nitrophenols; Sulfates; Triazoles; Water Pollutants, Chemical

2014
Dual blockade of the A1 and A2A adenosine receptor prevents amyloid beta toxicity in neuroblastoma cells exposed to aluminum chloride.
    The international journal of biochemistry & cell biology, 2014, Volume: 54

    Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Aluminum Chloride; Aluminum Compounds; Amyloid beta-Peptides; Apoptosis; Astringents; Blotting, Western; Caffeine; Cell Proliferation; Cells, Cultured; Chlorides; Humans; Lipid Peroxidation; Neuroblastoma; Neuroprotective Agents; Oxidative Stress; Purinergic P1 Receptor Antagonists; Pyrimidines; Reactive Oxygen Species; Receptor, Adenosine A1; Receptor, Adenosine A2A; RNA, Small Interfering; Triazoles; Xanthines

2014
Distinct pro-vigilant profile induced in rats by the mGluR5 potentiator LSN2814617.
    Psychopharmacology, 2015, Volume: 232, Issue:21-22

    Topics: Animals; Arousal; Benzhydryl Compounds; Biofeedback, Psychology; Caffeine; Central Nervous System Stimulants; Conditioning, Operant; Dextroamphetamine; Electroencephalography; Excitatory Amino Acid Agonists; Male; Modafinil; Oxadiazoles; Psychomotor Performance; Pyridines; Rats; Rats, Wistar; Reaction Time; Receptor, Metabotropic Glutamate 5; Sleep; Sleep Deprivation; Sleep, REM; Triazoles

2015
Effect of adenosine system in the action of oseltamivir on behavior in mice.
    Neuroscience letters, 2015, Jul-10, Volume: 599

    Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Antiviral Agents; Behavior, Animal; Caffeine; Dose-Response Relationship, Drug; Drug Interactions; Male; Mice; Neuraminidase; Oseltamivir; Phenethylamines; Pyrimidines; Receptors, Adenosine A2; Triazoles; Walking

2015
Caffeine promotes anti-tumor immune response during tumor initiation: Involvement of the adenosine A2A receptor.
    Biochemical pharmacology, 2015, Nov-01, Volume: 98, Issue:1

    Topics: Adenosine A2 Receptor Antagonists; Animals; Caffeine; Cell Line, Tumor; Cyclopentanes; Fibrosarcoma; Mice; Mice, Knockout; Neoplasms, Experimental; Receptor, Adenosine A2A; Triazines; Triazoles

2015
Caffeine Suppresses the Activation of Hepatic Stellate Cells cAMP-Independently by Antagonizing Adenosine Receptors.
    Biological & pharmaceutical bulletin, 2017, Volume: 40, Issue:5

    Topics: Animals; Caffeine; Cells, Cultured; Chelating Agents; Cyclic AMP; Dose-Response Relationship, Drug; Egtazic Acid; Hepatic Stellate Cells; Liver Cirrhosis; Male; MAP Kinase Signaling System; Mice; Phosphodiesterase Inhibitors; Phosphorylation; Quinazolines; Receptors, Purinergic P1; Triazoles

2017
Caffeine accelerates recovery from general anesthesia via multiple pathways.
    Journal of neurophysiology, 2017, 09-01, Volume: 118, Issue:3

    Topics: Adenosine A2 Receptor Antagonists; Anesthesia, General; Anesthetics, General; Animals; Brain; Caffeine; Central Nervous System Stimulants; Colforsin; Cyclic AMP; Delayed Emergence from Anesthesia; Isoflurane; Pyrimidines; Rats; Rats, Sprague-Dawley; Triazoles

2017
Theacrine: A purine alkaloid from Camellia assamica var. kucha with a hypnotic property via the adenosine system.
    Neuroscience letters, 2017, 10-17, Volume: 659

    Topics: Adenosine; Alkaloids; Animals; Caffeine; Camellia; Drug Synergism; Hippocampus; Male; Mice; Pentobarbital; Pyrimidines; Rats; Sleep Initiation and Maintenance Disorders; Sleep Stages; Triazoles; Uric Acid; Xanthines

2017
Preemptive Caffeine Administration Blocks the Increase in Postoperative Pain Caused by Previous Sleep Loss in the Rat: A Potential Role for Preoptic Adenosine A2A Receptors in Sleep-Pain Interactions.
    Sleep, 2017, 09-01, Volume: 40, Issue:9

    Topics: Adenosine A2 Receptor Antagonists; Animals; Caffeine; Female; Hyperalgesia; Male; Pain, Postoperative; Preoptic Area; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Sex Characteristics; Sleep; Sleep Deprivation; Triazines; Triazoles

2017
Effects of caffeine and phosphodiesterase inhibitors on activation of neonatal T lymphocytes.
    Immunobiology, 2018, Volume: 223, Issue:11

    Topics: Adenosine A2 Receptor Antagonists; Adult; Aging; Caffeine; Calcium Signaling; Cells, Cultured; Cyclic AMP; Cytokines; Female; Humans; Infant, Newborn; Leukocytes, Mononuclear; Lymphocyte Activation; Male; Milrinone; Phosphodiesterase Inhibitors; Reactive Oxygen Species; Sildenafil Citrate; T-Lymphocytes; Triazines; Triazoles

2018
Caffeine Exacerbates Postictal Hypoxia.
    Neuroscience, 2019, 12-01, Volume: 422

    Topics: Adenosine; Animals; CA1 Region, Hippocampal; Caffeine; Dose-Response Relationship, Drug; Hypoxia; Kindling, Neurologic; Male; Oxygen; Phenethylamines; Pyrimidines; Rats; Receptors, Adenosine A2; Seizures; Triazoles

2019
Prolonged caffeine intake decreases alveolar bone damage induced by binge-like ethanol consumption in adolescent female rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 130

    Topics: Adenosine A2 Receptor Antagonists; Alveolar Bone Loss; Animals; Binge Drinking; Bone Density; Caffeine; Ethanol; Female; Neuroprotective Agents; Periodontitis; Pyrimidines; Rats; Rats, Wistar; Triazoles; X-Ray Microtomography

2020
Design, synthesis, and structure-activity relationship of caffeine-based triazoles as dual AChE and BACE-1 inhibitors.
    Drug development research, 2022, Volume: 83, Issue:8

    Topics: Acetylcholinesterase; Alzheimer Disease; Biological Products; Caffeine; Cholinesterase Inhibitors; Humans; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship; Triazoles

2022