Compounds > allylisopropylacetamide
Page last updated: 2024-09-21

allylisopropylacetamide

Description

Allylisopropylacetamide: An allylic compound that acts as a suicide inactivator of CYTOCHROME P450 by covalently binding to its heme moiety or surrounding protein. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID9297
SCHEMBL ID3322985
MeSH IDM0000754

Synonyms (18)

Synonym
ai3-61022
4-pentenamide, 2-(1-methylethyl)-
allylisopropylacetamide
299-78-5
2-propan-2-ylpent-4-enamide
2-isopropylpent-4-enamide
2-isopropyl-4-pentenamide
AKOS006278029
unii-zof4719qs5
zof4719qs5 ,
4-pentenamide,2-(1-methylethyl)-
SCHEMBL3322985
2-allyl-2-isopropylacetamide
W18852
Q27295821
2-(propan-2-yl)pent-4-enimidic acid
DTXSID20952350
WS-01610

Research Excerpts

Overview

ExcerptReference
"Allylisopropylacetamide is shown to be a suicide substrate for the phenobarbital-inducible cytochromes P-450. "( Loosemore, MJ; Walsh, C; Wogan, GN, 1981)

Research

Studies (277)

TimeframeStudies, This Drug (%)All Drugs %
pre-1990240 (86.64)18.7374
1990's27 (9.75)18.2507
2000's8 (2.89)29.6817
2010's2 (0.72)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews9 (3.19%)6.00%
Case Studies1 (0.35%)4.05%
Observational0 (0.00%)0.25%
Other272 (96.45%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
pentylenetetrazole[no description available]medium10organic heterobicyclic compound;
organonitrogen heterocyclic compound
valnoctamide[no description available]medium10fatty amide
valproic acid[no description available]medium40branched-chain fatty acid;
branched-chain saturated fatty acid		anticonvulsant;
antimanic drug;
EC 3.5.1.98 (histone deacetylase) inhibitor;
GABA agent;
neuroprotective agent;
psychotropic drug;
teratogenic agent
propylisopropylacetamide[no description available]medium210
dicarbethoxydihydrocollidine[no description available]medium320dihydropyridine;
ethyl ester		hepatic steatosis inducing agent
heme[no description available]medium1110
glutathione disulfide[no description available]medium10glutathione derivative;
organic disulfide		Escherichia coli metabolite;
mouse metabolite
nadp[no description available]medium140
geldanamycin[no description available]medium10
reserpine[no description available]medium10alkaloid ester;
methyl ester;
yohimban alkaloid		adrenergic uptake inhibitor;
antihypertensive agent;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
environmental contaminant;
first generation antipsychotic;
plant metabolite;
xenobiotic
apronalide[no description available]medium30N-acylurea
amitrole[no description available]medium90aromatic amine;
triazoles		carotenoid biosynthesis inhibitor;
EC 1.11.1.6 (catalase) inhibitor;
herbicide
urea[no description available]medium50isourea;
monocarboxylic acid amide;
one-carbon compound		Daphnia magna metabolite;
Escherichia coli metabolite;
fertilizer;
flour treatment agent;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
triazoles[no description available]medium601,2,3-triazole
aminolevulinic acid[no description available]medium2904-oxo monocarboxylic acid;
amino acid zwitterion;
delta-amino acid		antineoplastic agent;
dermatologic drug;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
photosensitizing agent;
plant metabolite;
prodrug;
Saccharomyces cerevisiae metabolite
barbital[no description available]medium30barbituratesdrug allergen
griseofulvin[no description available]medium501-benzofurans;
antibiotic antifungal drug;
benzofuran antifungal drug;
organochlorine compound;
oxaspiro compound		antibacterial agent;
Penicillium metabolite
tryptophan[no description available]medium30erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
tryptophan zwitterion;
tryptophan		antidepressant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
porphobilinogen[no description available]medium140aralkylamino compound;
dicarboxylic acid;
pyrroles		Escherichia coli metabolite;
metabolite;
mouse metabolite
succinylacetone[no description available]medium40beta-diketone;
dioxo monocarboxylic acid		human metabolite
phenobarbital[no description available]medium720barbituratesanticonvulsant;
drug allergen;
excitatory amino acid antagonist;
sedative
diethyl maleate[no description available]medium20ethyl ester;
maleate ester		glutathione depleting agent
3-methylcholanthrene[no description available]medium170ortho- and peri-fused polycyclic arenearyl hydrocarbon receptor agonist;
carcinogenic agent
p-dimethylaminoazobenzene[no description available]medium20azobenzenes
thyroxine[no description available]medium202-halophenol;
iodophenol;
L-phenylalanine derivative;
non-proteinogenic L-alpha-amino acid;
thyroxine zwitterion;
thyroxine		antithyroid drug;
human metabolite;
mouse metabolite;
thyroid hormone
benzo(a)pyrene[no description available]medium30ortho- and peri-fused polycyclic arenecarcinogenic agent;
mouse metabolite
9,10-dimethyl-1,2-benzanthracene[no description available]medium30ortho-fused polycyclic arene;
tetraphenes		carcinogenic agent
bucladesine[no description available]medium1003',5'-cyclic purine nucleotide
triiodothyronine[no description available]medium402-halophenol;
amino acid zwitterion;
iodophenol;
iodothyronine		human metabolite;
mouse metabolite;
thyroid hormone
8-bromo cyclic adenosine monophosphate[no description available]medium103',5'-cyclic purine nucleotide;
adenyl ribonucleotide;
organobromine compound		antidepressant;
protein kinase agonist
thiamphenicol[no description available]medium10monocarboxylic acid amide;
sulfone		antimicrobial agent;
immunosuppressive agent
cycloheximide[no description available]medium170antibiotic fungicide;
cyclic ketone;
dicarboximide;
piperidine antibiotic;
piperidones;
secondary alcohol		anticoronaviral agent;
bacterial metabolite;
ferroptosis inhibitor;
neuroprotective agent;
protein synthesis inhibitor
methionine sulfoximine[no description available]medium10methionine derivative;
non-proteinogenic alpha-amino acid;
sulfoximide
phenolsulfonphthalein[no description available]medium302,1-benzoxathiole;
arenesulfonate ester;
phenols;
sultone		acid-base indicator;
diagnostic agent;
two-colour indicator
buthionine sulfoximine[no description available]medium10diastereoisomeric mixture;
homocysteines;
non-proteinogenic alpha-amino acid;
sulfoximide		EC 6.3.2.2 (glutamate--cysteine ligase) inhibitor;
ferroptosis inducer
serine[no description available]medium20L-alpha-amino acid;
proteinogenic amino acid;
serine family amino acid;
serine zwitterion;
serine		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
glycine[no description available]medium70alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid		EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical
isobutyl alcohol[no description available]medium10alkyl alcohol;
primary alcohol		Saccharomyces cerevisiae metabolite
aminopyrine[no description available]medium10pyrazolone;
tertiary amino compound		antipyretic;
environmental contaminant;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic
3,4,3',4'-tetrachlorobiphenyl[no description available]medium10dichlorobenzene;
tetrachlorobiphenyl
isopentyl alcohol[no description available]medium10alkyl alcohol;
primary alcohol;
volatile organic compound		antifungal agent;
Saccharomyces cerevisiae metabolite;
xenobiotic metabolite
1-butanol[no description available]medium10alkyl alcohol;
primary alcohol;
short-chain primary fatty alcohol		human metabolite;
mouse metabolite;
protic solvent
n-pentanol[no description available]medium10pentanol;
short-chain primary fatty alcohol		human metabolite;
plant metabolite
niacinamide[no description available]medium10pyridine alkaloid;
pyridinecarboxamide;
vitamin B3		anti-inflammatory agent;
antioxidant;
cofactor;
EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
Escherichia coli metabolite;
geroprotector;
human urinary metabolite;
metabolite;
mouse metabolite;
neuroprotective agent;
Saccharomyces cerevisiae metabolite;
Sir2 inhibitor
hexobarbital[no description available]medium50barbiturates
methylphenazonium methosulfate[no description available]medium10azaheterocycle sulfate salt;
phenazines
zinc protoporphyrin ix[no description available]medium20
cobaltiprotoporphyrin[no description available]medium20
4-butyrolactone[no description available]medium10butan-4-olidemetabolite;
neurotoxin
clofibrate[no description available]medium40aromatic ether;
ethyl ester;
monochlorobenzenes		anticholesteremic drug;
antilipemic drug;
geroprotector;
PPARalpha agonist
cimetidine[no description available]medium20aliphatic sulfide;
guanidines;
imidazoles;
nitrile		adjuvant;
analgesic;
anti-ulcer drug;
H2-receptor antagonist;
P450 inhibitor
nad[no description available]medium30organophosphate oxoanioncofactor;
human metabolite;
hydrogen acceptor;
Saccharomyces cerevisiae metabolite
selenium[no description available]medium10chalcogen;
nonmetal atom		micronutrient
chlorodiphenyl (54% chlorine)[no description available]medium10
beta-naphthoflavone[no description available]medium30extended flavonoid;
naphtho-gamma-pyrone;
organic heterotricyclic compound		aryl hydrocarbon receptor agonist
antipyrine[no description available]medium10pyrazoloneantipyretic;
cyclooxygenase 3 inhibitor;
environmental contaminant;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic
diethylallylacetamide[no description available]medium10fatty amide
edetic acid[no description available]medium40ethylenediamine derivative;
polyamino carboxylic acid;
tetracarboxylic acid		anticoagulant;
antidote;
chelator;
copper chelator;
geroprotector
cobalt[no description available]medium90cobalt group element atom;
metal allergen		micronutrient
cobaltous chloride[no description available]medium30cobalt salt;
inorganic chloride		allergen;
calcium channel blocker;
sensitiser;
two-colour indicator
leucine[no description available]medium40amino acid zwitterion;
L-alpha-amino acid;
leucine;
proteinogenic amino acid;
pyruvate family amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
lead[no description available]medium30carbon group element atom;
elemental lead;
metal atom		neurotoxin
secobarbital[no description available]medium40barbituratesanaesthesia adjuvant;
GABA modulator;
sedative
mitotane[no description available]medium10diarylmethane
carbon tetrachloride[no description available]medium40chlorocarbon;
chloromethanes		hepatotoxic agent;
refrigerant
sucrose[no description available]medium10glycosyl glycosidealgal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
sweetening agent
D-fructopyranose[no description available]medium30cyclic hemiketal;
D-fructose;
fructopyranose		sweetening agent
aminoacetone[no description available]medium20methyl ketone;
propanones		Escherichia coli metabolite;
mouse metabolite
acetone[no description available]medium40ketone body;
methyl ketone;
propanones;
volatile organic compound		EC 3.5.1.4 (amidase) inhibitor;
human metabolite;
polar aprotic solvent
hexachlorobenzene[no description available]medium30aromatic fungicide;
chlorobenzenes		antifungal agrochemical;
carcinogenic agent;
persistent organic pollutant
norethindrone[no description available]medium1017beta-hydroxy steroid;
3-oxo-Delta(4) steroid;
terminal acetylenic compound;
tertiary alcohol		progestin;
synthetic oral contraceptive
cyproterone[no description available]medium1017alpha-hydroxy steroid;
20-oxo steroid;
3-oxo-Delta(4) steroid;
chlorinated steroid;
tertiary alpha-hydroxy ketone		androgen antagonist
propranolol[no description available]medium30naphthalenes;
propanolamine;
secondary amine		anti-arrhythmia drug;
antihypertensive agent;
anxiolytic drug;
beta-adrenergic antagonist;
environmental contaminant;
human blood serum metabolite;
vasodilator agent;
xenobiotic
propylene glycol[no description available]medium10glycol;
propane-1,2-diols		allergen;
human xenobiotic metabolite;
mouse metabolite;
protic solvent
chloramphenicol[no description available]medium20C-nitro compound;
carboxamide;
diol;
organochlorine compound		antibacterial drug;
antimicrobial agent;
Escherichia coli metabolite;
geroprotector;
Mycoplasma genitalium metabolite;
protein synthesis inhibitor
puromycin[no description available]medium20puromycinsantiinfective agent;
antimicrobial agent;
antineoplastic agent;
EC 3.4.11.14 (cytosol alanyl aminopeptidase) inhibitor;
EC 3.4.14.2 (dipeptidyl-peptidase II) inhibitor;
nucleoside antibiotic;
protein synthesis inhibitor
allopurinol[no description available]medium30nucleobase analogue;
organic heterobicyclic compound		antimetabolite;
EC 1.17.3.2 (xanthine oxidase) inhibitor;
gout suppressant;
radical scavenger
pregnenolone carbonitrile[no description available]medium10aliphatic nitrile
malondialdehyde[no description available]medium10dialdehydebiomarker
deferoxamine[no description available]medium80acyclic desferrioxaminebacterial metabolite;
ferroptosis inhibitor;
iron chelator;
siderophore
proadifen[no description available]medium100diarylmethane
propofol[no description available]medium10phenolsanticonvulsant;
antiemetic;
intravenous anaesthetic;
radical scavenger;
sedative
d-alpha tocopherol[no description available]medium10alpha-tocopherolalgal metabolite;
antiatherogenic agent;
anticoagulant;
antioxidant;
antiviral agent;
EC 2.7.11.13 (protein kinase C) inhibitor;
immunomodulator;
micronutrient;
nutraceutical;
plant metabolite
sulfamethazine[no description available]medium10pyrimidines;
sulfonamide antibiotic;
sulfonamide		antibacterial drug;
antiinfective agent;
antimicrobial agent;
carcinogenic agent;
drug allergen;
EC 2.5.1.15 (dihydropteroate synthase) inhibitor;
environmental contaminant;
ligand;
xenobiotic
barbituric acid[no description available]medium10barbituratesallergen;
xenobiotic
diazepam[no description available]medium101,4-benzodiazepinone;
organochlorine compound		anticonvulsant;
anxiolytic drug;
environmental contaminant;
sedative;
xenobiotic
oxytetracycline, anhydrous[no description available]medium10
protoporphyrin ix[no description available]medium20
norcocaine[no description available]medium10benzoate ester
cocaine[no description available]medium10benzoate ester;
methyl ester;
tertiary amino compound;
tropane alkaloid		adrenergic uptake inhibitor;
central nervous system stimulant;
dopamine uptake inhibitor;
environmental contaminant;
local anaesthetic;
mouse metabolite;
plant metabolite;
serotonin uptake inhibitor;
sodium channel blocker;
sympathomimetic agent;
vasoconstrictor agent;
xenobiotic
methylmercury hydroxide[no description available]medium10
dimethyl sulfoxide[no description available]medium40sulfoxide;
volatile organic compound		alkylating agent;
antidote;
Escherichia coli metabolite;
geroprotector;
MRI contrast agent;
non-narcotic analgesic;
polar aprotic solvent;
radical scavenger
glutethimide[no description available]medium10piperidines
dactinomycin[no description available]medium80actinomycinmutagen
etoprine[no description available]medium10
pyrimethamine[no description available]medium10aminopyrimidine;
monochlorobenzenes		antimalarial;
antiprotozoal drug;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor
3-(2-(2,4,6-trimethylphenyl)thioethyl)-4-methylsydnone[no description available]medium20
clonidine[no description available]medium10clonidine;
imidazoline
1-aminobenzotriazole[no description available]medium10
enflurane[no description available]medium10ether;
organochlorine compound;
organofluorine compound		anaesthetic
isoflurane[no description available]medium10organofluorine compoundinhalation anaesthetic
ether[no description available]medium10ether;
volatile organic compound		inhalation anaesthetic;
non-polar solvent;
refrigerant
safrole[no description available]medium10benzodioxolesflavouring agent;
insecticide;
metabolite;
plant metabolite
glucagon[no description available]medium30peptide hormone
meprobamate[no description available]medium10organic molecular entity
bromotrichloromethane[no description available]medium10
chloroform[no description available]medium10chloromethanes;
one-carbon compound		carcinogenic agent;
central nervous system drug;
inhalation anaesthetic;
non-polar solvent;
refrigerant
carbon monoxide[no description available]medium40carbon oxide;
gas molecular entity;
one-carbon compound		biomarker;
EC 1.9.3.1 (cytochrome c oxidase) inhibitor;
human metabolite;
ligand;
metabolite;
mitochondrial respiratory-chain inhibitor;
mouse metabolite;
neurotoxin;
neurotransmitter;
P450 inhibitor;
probe;
signalling molecule;
vasodilator agent
nafenopin[no description available]medium20aromatic ether;
monocarboxylic acid
pentobarbital[no description available]medium40barbituratesGABAA receptor agonist
1-methyl-3-isobutylxanthine[no description available]medium103-isobutyl-1-methylxanthine
pyridoxal phosphate[no description available]medium10methylpyridines;
monohydroxypyridine;
pyridinecarbaldehyde;
vitamin B6 phosphate		coenzyme;
cofactor;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
thiopental[no description available]medium10barbituratesanticonvulsant;
drug allergen;
environmental contaminant;
intravenous anaesthetic;
sedative;
xenobiotic
theophylline[no description available]medium30dimethylxanthineadenosine receptor antagonist;
anti-asthmatic drug;
anti-inflammatory agent;
bronchodilator agent;
drug metabolite;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
fungal metabolite;
human blood serum metabolite;
immunomodulator;
muscle relaxant;
vasodilator agent
zoxazolamine[no description available]medium10benzoxazole
bilirubin[no description available]medium30biladienes;
dicarboxylic acid		antioxidant;
human metabolite;
mouse metabolite
dimethylnitrosamine[no description available]medium10nitrosaminegeroprotector;
mutagen
valerates[no description available]medium20short-chain fatty acid anion;
straight-chain saturated fatty acid anion		plant metabolite
spironolactone[no description available]medium103-oxo-Delta(4) steroid;
oxaspiro compound;
steroid lactone;
thioester		aldosterone antagonist;
antihypertensive agent;
diuretic;
environmental contaminant;
xenobiotic
clofenapate[no description available]medium10
phosphorus radioisotopes[no description available]medium10
pregnenolone[no description available]medium1020-oxo steroid;
3beta-hydroxy-Delta(5)-steroid;
C21-steroid		human metabolite;
mouse metabolite
iodine[no description available]medium10halide anion;
monoatomic iodine		human metabolite
uridine[no description available]medium20uridinesdrug metabolite;
fundamental metabolite;
human metabolite
uridine diphosphate glucose[no description available]medium10UDP-D-glucosefundamental metabolite
acrolein[no description available]medium10enalherbicide;
human xenobiotic metabolite;
toxin
dihydropyridines[no description available]medium20
triethylenephosphoramide[no description available]medium10phosphoramide
thiotepa[no description available]medium10aziridines
chlorpropamide[no description available]medium10monochlorobenzenes;
N-sulfonylurea		hypoglycemic agent;
insulin secretagogue
phenformin[no description available]medium10biguanidesantineoplastic agent;
geroprotector;
hypoglycemic agent
4,5-dioxovaleric acid[no description available]medium10dioxo monocarboxylic acid
alanine[no description available]medium10alanine zwitterion;
alanine;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid		EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor;
fundamental metabolite
colchicine[no description available]medium10alkaloid;
colchicine		anti-inflammatory agent;
gout suppressant;
mutagen
orabase[no description available]medium10
tungstate[no description available]medium10divalent inorganic anion;
tungsten oxoanion
azacitidine[no description available]medium10N-glycosyl-1,3,5-triazine;
nucleoside analogue		antineoplastic agent
acetylcysteine[no description available]medium10acetylcysteine;
L-cysteine derivative;
N-acetyl-L-amino acid		antidote to paracetamol poisoning;
antiinfective agent;
antioxidant;
antiviral drug;
ferroptosis inhibitor;
geroprotector;
human metabolite;
mucolytic;
radical scavenger;
vulnerary
dithiothreitol[no description available]medium101,4-dimercaptobutane-2,3-diol;
butanediols;
dithiol;
glycol;
thiol		chelator;
human metabolite;
reducing agent
tungsten[no description available]medium10chromium group element atommicronutrient
dipropylacetamide[no description available]medium10fatty amidegeroprotector;
metabolite;
teratogenic agent
ferrous chloride[no description available]medium10iron coordination entity
cadmium[no description available]medium10cadmium molecular entity;
zinc group element atom
sulfonomethane[no description available]medium10
norharman[no description available]medium10beta-carbolines;
mancude organic heterotricyclic parent		fungal metabolite;
marine metabolite
harmine[no description available]medium10harmala alkaloidanti-HIV agent;
EC 1.4.3.4 (monoamine oxidase) inhibitor;
metabolite
7,8-dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide[no description available]medium20epoxideintercalator
cyclopenta(c,d)pyrene[no description available]medium10pyrenes
triiodothyronine, reverse[no description available]medium103,3',5'-triiodothyronine;
amino acid zwitterion
heme arginate[no description available]medium10
arginine[no description available]medium10arginine;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		biomarker;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical
mesoporphyrin ix[no description available]medium10
3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine[no description available]medium10
iron(iii)-deuteroporphyrin[no description available]medium10
benzo(a)pyrene 7,8-dihydrodiol[no description available]medium10pyrenes
deoxyglucose[no description available]medium10
3-o-methylglucose[no description available]medium10D-aldohexose derivative
diacetylfluorescein[no description available]medium10
erythrosine[no description available]medium10
tin[no description available]medium10carbon group element atom;
elemental tin;
metal atom		micronutrient
carbamazepine[no description available]medium10dibenzoazepine;
ureas		analgesic;
anticonvulsant;
antimanic drug;
drug allergen;
EC 3.5.1.98 (histone deacetylase) inhibitor;
environmental contaminant;
glutamate transporter activator;
mitogen;
non-narcotic analgesic;
sodium channel blocker;
xenobiotic
bromine[no description available]medium10diatomic bromine
diazoxide[no description available]medium10benzothiadiazine;
organochlorine compound;
sulfone		antihypertensive agent;
beta-adrenergic agonist;
bronchodilator agent;
cardiotonic drug;
diuretic;
K-ATP channel agonist;
sodium channel blocker;
sympathomimetic agent;
vasodilator agent
glycerol[no description available]medium10alditol;
triol		algal metabolite;
detergent;
Escherichia coli metabolite;
geroprotector;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
solvent
phenylbutazone[no description available]medium30pyrazolidinesantirheumatic drug;
EC 1.1.1.184 [carbonyl reductase (NADPH)] inhibitor;
metabolite;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
peripheral nervous system drug
isoproterenol[no description available]medium10catechols;
secondary alcohol;
secondary amino compound		beta-adrenergic agonist;
bronchodilator agent;
cardiotonic drug;
sympathomimetic agent
hydrazine[no description available]medium10azane;
hydrazines		EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor
nitrofurantoin[no description available]medium10imidazolidine-2,4-dione;
nitrofuran antibiotic;
organonitrogen heterocyclic antibiotic;
organooxygen heterocyclic antibiotic		antibacterial drug;
antiinfective agent;
hepatotoxic agent
thiazoles[no description available]medium101,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
ozone[no description available]medium10elemental molecule;
gas molecular entity;
reactive oxygen species;
triatomic oxygen		antiseptic drug;
disinfectant;
electrophilic reagent;
greenhouse gas;
mutagen;
oxidising agent;
tracer
thiophenes[no description available]medium10mancude organic heteromonocyclic parent;
monocyclic heteroarene;
thiophenes;
volatile organic compound		non-polar solvent
adenosine monophosphate[no description available]medium10adenosine 5'-phosphate;
purine ribonucleoside 5'-monophosphate		adenosine A1 receptor agonist;
cofactor;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
EC 3.1.3.11 (fructose-bisphosphatase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
adenosine diphosphate[no description available]medium10adenosine 5'-phosphate;
purine ribonucleoside 5'-diphosphate		fundamental metabolite;
human metabolite
cyclic gmp[no description available]medium103',5'-cyclic purine nucleotide;
guanyl ribonucleotide		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
adenosine[no description available]medium10adenosines;
purines D-ribonucleoside		analgesic;
anti-arrhythmia drug;
fundamental metabolite;
human metabolite;
vasodilator agent
phenyl acetate[no description available]medium30benzenes;
phenyl acetates
mevalonic acid[no description available]medium203,5-dihydroxy-3-methylpentanoic acid
kynurenine[no description available]medium10aromatic ketone;
non-proteinogenic alpha-amino acid;
substituted aniline		human metabolite
cyanides[no description available]medium10pseudohalide anionEC 1.9.3.1 (cytochrome c oxidase) inhibitor
caffeine[no description available]medium10purine alkaloid;
trimethylxanthine		adenosine A2A receptor antagonist;
adenosine receptor antagonist;
adjuvant;
central nervous system stimulant;
diuretic;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
environmental contaminant;
food additive;
fungal metabolite;
geroprotector;
human blood serum metabolite;
mouse metabolite;
mutagen;
plant metabolite;
psychotropic drug;
ryanodine receptor agonist;
xenobiotic
manganese[no description available]medium10elemental manganese;
manganese group element atom		Escherichia coli metabolite;
micronutrient
etiocholanolone[no description available]medium2017-oxo steroid;
3alpha-hydroxy steroid;
androstanoid		human metabolite;
mouse metabolite
coenzyme a[no description available]medium10adenosine 3',5'-bisphosphatecoenzyme;
Escherichia coli metabolite;
mouse metabolite
quinidine[no description available]medium10cinchona alkaloidalpha-adrenergic antagonist;
anti-arrhythmia drug;
antimalarial;
drug allergen;
EC 1.14.13.181 (13-deoxydaunorubicin hydroxylase) inhibitor;
EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor;
muscarinic antagonist;
P450 inhibitor;
potassium channel blocker;
sodium channel blocker
propane[no description available]medium10alkane;
gas molecular entity		food propellant
acetyl coenzyme a[no description available]medium10acyl-CoAacyl donor;
coenzyme;
effector;
fundamental metabolite
fumarates[no description available]medium10butenedioate;
C4-dicarboxylate		human metabolite;
metabolite;
Saccharomyces cerevisiae metabolite
aspartic acid[no description available]medium10aspartate family amino acid;
aspartic acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
mouse metabolite;
neurotransmitter
hydrogen[no description available]medium10elemental hydrogen;
elemental molecule;
gas molecular entity		antioxidant;
electron donor;
food packaging gas;
fuel;
human metabolite
digitonin[no description available]medium10
alkenes[no description available]medium10
ConditionIndicatedRelationship StrengthStudiesTrials
Abnormalities, Drug-Induced0low10
Absence Seizure0low20
Absence Seizures0low20
Acute Disease0low30
Acute Liver Injury, Drug-Induced0low60
Acute Porphyria0low50
Aging0low60
Allodynia0low10
Allodynia, Mechanical0low10
Allodynia, Tactile0low10
Allodynia, Thermal0low10
Alloxan Diabetes0low40
Anesthesia0low10
Anochlesia0low20
Atonic Absence Seizure0low20
Atonic Absence Seizures0low20
Atonic Seizure0low20
Atonic Seizures0low20
B16 Melanoma0low10
Behavior Disorders0low10
Benign Neoplasms0low10
Bile Duct Obstruction0low10
Biliary Stasis0low10
Body Weight0low10
Cancer0low10
Cancer of Liver0low10
Cancer of the Liver0low10
Cancer, Hepatocellular0low10
Carcinoma 256, Walker0low10
Carcinoma, Hepatocellular0low10
Carcinosarcoma 256, Walker0low10
Catalepsy0low20
Cell Transformation, Neoplastic0low40
Cerea Flexibilitas0low20
Chemical and Drug Induced Liver Injury0low60
Chemically-Induced Liver Toxicity0low60
Cholestasis0low10
Clonic Seizure0low20
Clonic Seizures0low20
Complex Partial Seizure0low20
Complex Partial Seizures0low20
Condition, Preneoplastic0low10
Conditions, Preneoplastic0low10
Convulsion0low20
Convulsion, Non-Epileptic0low20
Convulsions0low20
Convulsive Generalized Seizure Disorder0low10
Convulsive Seizure0low20
Convulsive Seizure Disorder, Generalized0low10
Convulsive Seizures0low20
Deficiency, Riboflavin0low10
Depression0low10
Depression, Endogenous0low10
Depression, Neurotic0low10
Depression, Unipolar0low10
Depressive Disorder0low10
Depressive Syndrome0low10
Di Guglielmo Disease0low20
Di Guglielmo's Disease0low20
Diabetes Mellitus, Experimental0low40
Diagnosis, Psychiatric0low10
Disease Models, Animal0low50
Drug-Induced Abnormalities0low10
Drug-Induced Acute Liver Injury0low60
Drug-Induced Liver Disease0low60
Drug-Induced Liver Injury0low60
EHS Tumor0low10
Elevated Cholesterol0low10
Epilepsy, Akinetic0low10
Epilepsy, Atonic0low10
Epilepsy, Generalized0low10
Epilepsy, Tonic0low10
Epileptic Seizure0low20
Epileptic Seizures0low20
Erythremic Myelosis0low20
Erythroblastic Leukemia, Acute0low20
Erythroleukemia0low20
Experimental Diabetes Mellitus0low40
Experimental Hepatoma0low10
Experimental Hepatomas0low10
Experimental Leukemia0low10
Experimental Leukemias0low10
Experimental Liver Neoplasms0low10
Experimental Mammary Neoplasms0low20
Experimental Melanoma0low10
Experimental Melanomas0low10
Experimental Neoplasms0low10
Experimental Sarcoma0low10
Experimental Sarcomas0low10
Fatty Liver0low10
Fibrosarcoma0low10
Flexibility, Waxy0low20
Generalized Absence Seizure0low20
Generalized Absence Seizures0low20
Generalized Convulsive Epilepsy0low10
Generalized Nonconvulsive Epilepsy0low10
Generalized Nonconvulsive Seizure Disorder0low10
Generalized Onset Seizure Disorder0low10
Generalized Seizure Disorder, Convulsive0low10
Generalized Seizure Disorder, Nonconvulsive0low10
Generalized Tonic-Clonic Seizures0low20
Harding Passey Melanoma0low10
Hepatic Cancer0low10
Hepatic Neoplasms0low10
Hepatic Porphyria0low10
Hepatitis, Drug-Induced0low60
Hepatitis, Toxic0low60
Hepatocellular Cancer0low10
Hepatocellular Carcinoma0low10
Hepatoma0low10
Hepatoma, Experimental0low10
Hepatoma, Morris0low10
Hepatoma, Novikoff0low10
Hepatomas, Experimental0low10
High Cholesterol Levels0low10
Hydroxymethylbilane Synthase Deficiency0low50
Hyperalgesia0low10
Hyperalgesia, Mechanical0low10
Hyperalgesia, Primary0low10
Hyperalgesia, Secondary0low10
Hyperalgesia, Tactile0low10
Hyperalgesia, Thermal0low10
Hyperalgesic Sensations0low10
Hyperalgia0low10
Hyperalgia, Mechanical0low10
Hyperalgia, Primary0low10
Hyperalgia, Secondary0low10
Hypercholesteremia0low10
Hypercholesterolemia0low10
Hypothermia0low10
Hypothermia, Accidental0low10
Incontinentia Pigmenti Achromians0low10
Inflammation0low10
Innate Inflammatory Response0low10
Ito Syndrome0low10
Jacksonian Seizure0low20
Leukemia Model, Animal0low10
Leukemia, Erythroblastic, Acute0low20
Leukemia, Experimental0low10
Leukemia, Myeloid, Acute, M60low20
Leukemias, Experimental0low10
Liver Cancer0low10
Liver Cancer, Adult0low10
Liver Cell Carcinoma0low10
Liver Cell Carcinoma, Adult0low10
Liver Diseases0low40
Liver Dysfunction0low40
Liver Injury, Drug-Induced0low60
Liver Injury, Drug-Induced, Acute0low60
Liver Neoplasms0low10
Liver Neoplasms, Experimental0low10
Liver Steatosis0low10
Malignancy0low10
Malignant Neoplasms0low10
Mammary Neoplasms, Experimental0low20
Mechanical Allodynia0low10
Mechanical Hyperalgesia0low10
Melancholia0low10
Melanoma, B160low10
Melanoma, Cloudman S910low10
Melanoma, Experimental0low10
Melanoma, Harding-Passey0low10
Melanomas, Experimental0low10
Mental Disorders0low10
Mental Disorders, Severe0low10
Mental Illness0low10
Myeloid Leukemia, Acute, M60low20
Myoclonic Seizure0low20
Myoclonic Seizures0low20
Neoplasia0low10
Neoplasm0low10
Neoplasms0low10
Neoplasms, Benign0low10
Neoplasms, Experimental0low10
Neoplasms, Experimental Liver0low10
Neoplasms, Experimental Mammary0low20
Neoplasms, Hepatic0low10
Neoplasms, Liver0low10
Neoplastic Cell Transformation0low40
Neoplastic Transformation, Cell0low40
Nerve Pain0low10
Neuralgia0low10
Neuralgia, Atypical0low10
Neuralgia, Iliohypogastric Nerve0low10
Neuralgia, Ilioinguinal0low10
Neuralgia, Perineal0low10
Neuralgia, Stump0low10
Neuralgia, Supraorbital0low10
Neuralgia, Vidian0low10
Neurodynia0low10
Neuropathic Pain0low10
Neurosis, Depressive0low10
Non-Epileptic Seizure0low20
Non-Epileptic Seizures0low20
Nonconvulsive Generalized Seizure Disorder0low10
Nonconvulsive Seizure Disorder, Generalized0low10
Nonepileptic Seizure0low20
Nonepileptic Seizures0low20
Palsy0low10
Paralysis0low10
Paroxysmal Nerve Pain0low10
Partial Seizure0low20
Partial Seizures0low20
PBGD Deficiency0low50
Petit Mal Convulsion0low20
Pigmentation Disorders0low10
Plegia0low10
Porphobilinogen Deaminase Deficiency0low50
Porphyria0low310
Porphyria, Acute Intermittent0low50
Porphyria, Hepatic0low10
Porphyria, Swedish Type0low50
Porphyrias0low310
Porphyrias, Hepatic0low10
Porphyrin Disorder0low310
Precancerous Conditions0low10
Pregnancy0low80
Preneoplastic Condition0low10
Preneoplastic Conditions0low10
Psychiatric Diagnosis0low10
Psychiatric Diseases0low10
Psychiatric Disorders0low10
Psychiatric Illness0low10
Psychoses0low10
Psychosis0low10
Psychosis, Brief Reactive0low10
Psychotic Disorders0low10
Riboflavin Deficiency0low10
Sarcoma, Engelbreth-Holm-Swarm0low10
Sarcoma, Experimental0low10
Sarcoma, Jensen0low10
Sarcomas, Experimental0low10
Schamberg Disease0low10
Schamberg's Disease0low10
Schizoaffective Disorder0low10
Schizophreniform Disorders0low10
Seizure0low20
Seizure Disorder, Convulsive, Generalized0low10
Seizure Disorder, Generalized0low10
Seizure Disorder, Generalized Nonconvulsive0low10
Seizure Disorder, Generalized Onset0low10
Seizure Disorder, Generalized, Convulsive0low10
Seizure Disorder, Nonconvulsive Generalized0low10
Seizures0low20
Seizures, Auditory0low20
Seizures, Clonic0low20
Seizures, Convulsive0low20
Seizures, Epileptic0low20
Seizures, Focal0low20
Seizures, Generalized0low20
Seizures, Gustatory0low20
Seizures, Motor0low20
Seizures, Olfactory0low20
Seizures, Sensory0low20
Seizures, Somatosensory0low20
Seizures, Tonic0low20
Seizures, Tonic-Clonic0low20
Seizures, Vertiginous0low20
Seizures, Vestibular0low20
Seizures, Visual0low20
Sensitivity and Specificity0low10
Single Seizure0low20
Starvation0low80
Steatohepatitis0low10
Steatosis of Liver0low10
Streptozocin Diabetes0low40
Streptozotocin Diabetes0low40
Symptomatic Generalized Epilepsy0low10
Tactile Allodynia0low10
Thermal Allodynia0low10
Todd Paralysis0low10
Todd's Paralysis0low10
Tonic Clonic Seizure0low20
Tonic Seizure0low20
Tonic Seizures0low20
Tonic-Clonic Seizure0low20
Tonic-Clonic Seizures0low20
Toxic Hepatitis0low60
Transformation, Neoplastic Cell0low40
Tumorigenic Transformation0low40
Tumors0low10
Unipolar Depression0low10
UPS Deficiency0low50
Uroporphyrinogen Synthase Deficiency0low50
Visceral Steatosis0low10

Research Highlights

Safety/Toxicity (2)

ArticleYear
Cocaine toxicity in cultured chicken hepatocytes: role of cytochrome P450.
Toxicology and applied pharmacology, Volume: 125, Issue: 2		1994
Inhibition of the acute toxicity and adrenocorticolytic effect of 7,12-dimethylbenz(a)anthracene by isopropylvaleramide and allylisopropylacetamide in the rat.
Cancer research, Volume: 35, Issue: 9		1975
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Pharmacokinetics (4)

ArticleYear
Evaluation of the enantioselective antiallodynic and pharmacokinetic profile of propylisopropylacetamide, a chiral isomer of valproic acid amide.
Neuropharmacology, Volume: 54, Issue: 4		2008
Characterization of the anticonvulsant profile and enantioselective pharmacokinetics of the chiral valproylamide propylisopropyl acetamide in rodents.
British journal of pharmacology, Volume: 138, Issue: 4		2003
Stereoselective pharmacokinetics and pharmacodynamics of propylisopropyl acetamide, a CNS-active chiral amide analog of valproic acid.
Pharmaceutical research, Volume: 16, Issue: 10		1999
Structure-pharmacokinetic relationships in a series of valpromide derivatives with antiepileptic activity.
Pharmaceutical research, Volume: 6, Issue: 8		1989
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Dosage (2)

ArticleYear
Iron and the liver. Acute and long-term effects of iron-loading on hepatic haem metabolism.
The Biochemical journal, Apr-15, Volume: 196, Issue: 1		1981
Effects of polychlorinated biphenyls on cytochrome P450 induction in the chick embryo hepatocyte culture.
Archives of biochemistry and biophysics, Nov-15, Volume: 275, Issue: 1		1989
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]