Compounds > triazoles
Page last updated: 2024-08-24

triazoles and Cirrhosis

triazoles has been researched along with Cirrhosis in 35 studies

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (2.86)18.2507
2000's3 (8.57)29.6817
2010's24 (68.57)24.3611
2020's7 (20.00)2.80

Authors

AuthorsStudies
Brimert, T; Gravelle, L; Johnsson, RE; Kahl-Knutson, B; Leffler, H; MacKinnon, A; Nilsson, UJ; Pedersen, A; Peterson, K; Roper, JA; Schambye, H; Slack, RJ; Tantawi, S; Zetterberg, FR1
Cho, I; Choi, J; Park, J; Sheen, YY1
Alexanian, M; Bagchi, RA; Cavasin, MA; Enyart, BY; Felisbino, MB; Haldar, SM; Hirsch, RA; Koch, KA; Lam, MPY; Lemieux, ME; Lin, CY; McKinsey, TA; Qi, J; Riching, AS; Smith, HE; Song, K; Srivastava, D; Stratton, MS1
Chen, B; Chen, J; Huang, M; Huang, S; Liu, Y; Sun, Y; Wang, B; Wang, C; Wang, X; Xiong, L; Zhao, N1
Fukui, K; Nangaku, M; Saito, H; Sugahara, M; Tanaka, T; Uchida, L; Wakashima, T1
Antolic, A; Bradner, JE; Brown, JD; Burke, MA; Conner, DA; DePalma, SR; Gorham, JM; Haldar, SM; Jiao, Z; Lee, DY; Lemieux, ME; Qi, J; Seidman, CE; Seidman, JG; Wakimoto, H1
Berinstein, JA; Cushing, KC; Higgins, PDR; Huang, S; Johnson, LA; Rodansky, ES; Spence, JR; Steiner, CA1
Anseth, KS; Batan, D; GonzalezRodriguez, A; Ma, H; Macdougall, LJ; Schroeder, ME; Weiss, RM1
Rockson, SG1
Herskind, C; Oakes, CC; Plass, C; Popanda, O; Schmezer, P; Valinciute, G; Veldwijk, MR; Weigel, C; Wenz, F1
Chang, K; Choo, EH; Hong, SK; Ihm, SH; Seung, KB1
Chen, WJ; Guo, M; Wang, HX1
Choi, EY; Kim, DK; Kim, KY; Kim, MT; Lim, YJ; Park, JH; Song, HY; Tsauo, J; Yoon, SH1
Asgharzadeh, F; Avan, A; Binabaj, MM; Ferns, GA; Hassanian, SM; Khazaei, M; Parizadeh, MR; Rahmani, F; Ryzhikov, M; Soleimani, A1
Ahmed, L; Babickova, J; Eikrem, Ø; Furriol, J; Gausdal, G; Landolt, L; Leh, S; Lorens, JB; Marti, HP; Osman, T; Scherer, A; Skogstrand, T; Suliman, S1
Duan, Q; Huang, T; Peng, Y; Wang, X; Xia, F; Yang, T; Zhang, W; Zhou, Y1
Ishibashi, T; Oshima, Y; Sonoda, KH; Takeda, A; Yang, Y; Yoshimura, T; Zhang, H1
Ares-Carrasco, S; Caro-Vadillo, A; Egido, J; Iborra, C; Lorenzo, O; Picatoste, B; Ramírez, E; Tuñón, J1
Beyer, C; Dees, C; Distler, A; Distler, JH; Distler, O; Kreuter, A; Lin, NY; Palumbo, K; Schett, G; Susok, L; Zerr, P; Zhang, Y1
Aguiar, CF; Andrade-Oliveira, V; Braga, TT; Câmara, NO; Castoldi, A; Correa-Costa, M; Hiyane, MI; Jancar, S; Malheiros, DM; Origassa, CS; Rios, FJ; Rodas, AC1
Aroor, A; Bostick, B; Habibi, J; Hayden, MR; Ma, L; Rehmer, N; Sowers, JR1
Kim, DK; Kim, JS; Kim, MJ; Lee, SJ; Nam, JS; Park, SA; Park, SY; Sheen, YY; Woo, HA1
Eguchi, A; Fujii, A; Hirotani, S; Iwasaku, T; Masuyama, T; Morisawa, D; Naito, Y; Oboshi, M; Okuhara, Y; Sawada, H1
Chung, BH; Jin, L; Lim, SW; Piao, SG; Yang, CW1
Alimena, G; Andriani, A; Bagnato, A; Breccia, M; Cedrone, M; Ciccone, F; De Muro, M; Di Veroli, A; Latagliata, R; Leonetti, SC; Maurillo, L; Montagna, C; Montanaro, M; Montefusco, E; Niscola, P; Porrini, R; Rago, A; Spadea, A; Spirito, F1
Abdullah, T; Baggio, LL; Bang, KW; Campbell, JE; Drucker, DJ; Mulvihill, EE; Ussher, JR; Varin, EM1
Azria, D; Bourgier, C; Crompton, N; Fenoglietto, P; Gourgou, S; Gutowski, M; Kerns, S; Lacombe, J; Lemanski, C; Ozsahin, M; Pèlegrin, A; Romieu, G; Rosenstein, B1
Gong, Y; He, T; Lu, C; Mu, J; Qin, Z; Zhao, Y; Zhou, B1
Chen, JF; Feng, L; Garcia, GE; Johnson, RJ; Truong, LD1
Böhm, M; Kazakov, A; Laufs, U; Lenski, M; Marx, N1
Guo, L; Hao, X; Ju, R; Li, J; Luo, L; Wang, C; Wu, D; Ye, C; Yu, X; Zhang, D; Zheng, R; Zhu, L1
Kim, DK; Kim, J; Park, HJ1
Chan, ES; Chen, JF; Cronstein, BN; Desai, A; Fernandez, P; Khoa, DN; Merchant, AA; Montesinos, MC; Pillinger, MH; Reiss, AB; Schwarzschild, MA; Tomic-Canic, M; Trzaska, S; Tung, CF1
Blackburn, MR; Chan, ES; Chiriboga, L; Cronstein, BN; Fernández, P; Trzaska, S; Wilder, T1
Ishidoya, S; Klahr, S; Morrissey, J1

Reviews

1 review(s) available for triazoles and Cirrhosis

ArticleYear
Role of angiotensin II in the tubulointerstitial fibrosis of obstructive nephropathy.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 1995, Volume: 26, Issue:1

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Collagen; Enalapril; Extracellular Matrix Proteins; Fibrosis; Kidney; Kidney Diseases; Kidney Tubules; Macrophages; Monocytes; Rats; RNA, Messenger; Tetrazoles; Transforming Growth Factor beta; Triazoles; Ureteral Obstruction

1995

Trials

1 trial(s) available for triazoles and Cirrhosis

ArticleYear
Concurrent or sequential letrozole with adjuvant breast radiotherapy: final results of the CO-HO-RT phase II randomized trial.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2016, Volume: 27, Issue:3

    Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Combined Modality Therapy; Female; Fibrosis; Genome-Wide Association Study; Humans; Letrozole; Middle Aged; Nitriles; Nuclear Proteins; Polymorphism, Single Nucleotide; Radiotherapy, Adjuvant; Triazoles

2016

Other Studies

33 other study(ies) available for triazoles and Cirrhosis

ArticleYear
Discovery and Optimization of the First Highly Effective and Orally Available Galectin-3 Inhibitors for Treatment of Fibrotic Disease.
    Journal of medicinal chemistry, 2022, 10-13, Volume: 65, Issue:19

    Topics: Animals; Bleomycin; Carbon Tetrachloride; Fibrosis; Galectin 3; Idiopathic Pulmonary Fibrosis; Liver Cirrhosis; Lung; Mice; Thiogalactosides; Triazoles

2022
Radiotherapy-induced oxidative stress and fibrosis in breast cancer are suppressed by vactosertib, a novel, orally bioavailable TGF-β/ALK5 inhibitor.
    Scientific reports, 2022, 09-27, Volume: 12, Issue:1

    Topics: Aniline Compounds; Animals; Female; Fibrocystic Breast Disease; Fibronectins; Fibrosis; Humans; Mice; Neoplasm Recurrence, Local; NF-E2-Related Factor 2; Oxidative Stress; Plasminogen Activator Inhibitor 1; Reactive Oxygen Species; Transforming Growth Factor beta; Transforming Growth Factors; Triazoles

2022
Dynamic Chromatin Targeting of BRD4 Stimulates Cardiac Fibroblast Activation.
    Circulation research, 2019, 09-13, Volume: 125, Issue:7

    Topics: Animals; Azepines; Cell Adhesion Molecules; Cells, Cultured; Chromatin; Enhancer Elements, Genetic; Epigenesis, Genetic; Extracellular Matrix; Female; Fibrosis; Heart Failure; Heart Ventricles; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred C57BL; Myofibroblasts; Nuclear Proteins; p38 Mitogen-Activated Protein Kinases; Protein Binding; Rats; Rats, Sprague-Dawley; RNA Polymerase II; Transcription Factors; Transcriptome; Transforming Growth Factor beta; Triazoles

2019
Pharmacological Targeting of BET Bromodomains Inhibits Lens Fibrosis via Downregulation of MYC Expression.
    Investigative ophthalmology & visual science, 2019, 11-01, Volume: 60, Issue:14

    Topics: Actins; Adult; Animals; Azepines; Blotting, Western; Cadherins; Cell Movement; Cell Proliferation; Down-Regulation; Epithelial Cells; Epithelial-Mesenchymal Transition; Fibronectins; Fibrosis; Humans; Lens, Crystalline; Proteins; Proto-Oncogene Proteins c-myc; Rabbits; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Thiazoles; Transforming Growth Factor beta2; Triazoles

2019
Effects of a prolyl hydroxylase inhibitor on kidney and cardiovascular complications in a rat model of chronic kidney disease.
    American journal of physiology. Renal physiology, 2020, 02-01, Volume: 318, Issue:2

    Topics: Animals; Apoptosis; Cell Line; Cytokines; Disease Models, Animal; Fibrosis; Hypertrophy, Left Ventricular; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation Mediators; Kidney; Male; Mitochondria, Heart; Myocytes, Cardiac; N-substituted Glycines; Neovascularization, Physiologic; Prolyl Hydroxylases; Prolyl-Hydroxylase Inhibitors; Pyridines; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; Signal Transduction; Triazoles; Ventricular Function, Left; Ventricular Remodeling

2020
BET bromodomain proteins regulate transcriptional reprogramming in genetic dilated cardiomyopathy.
    JCI insight, 2020, 08-06, Volume: 5, Issue:15

    Topics: Animals; Azepines; Calcium-Binding Proteins; Cardiomyopathy, Dilated; Fibrosis; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nuclear Proteins; Transcription Factors; Triazoles

2020
AXL Is a Potential Target for the Treatment of Intestinal Fibrosis.
    Inflammatory bowel diseases, 2021, 02-16, Volume: 27, Issue:3

    Topics: Axl Receptor Tyrosine Kinase; Benzocycloheptenes; Crohn Disease; Fibrosis; Humans; Intestinal Failure; Intestines; Organoids; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Transforming Growth Factor beta1; Triazoles

2021
Calcium Signaling Regulates Valvular Interstitial Cell Alignment and Myofibroblast Activation in Fast-Relaxing Boronate Hydrogels.
    Macromolecular bioscience, 2020, Volume: 20, Issue:12

    Topics: Animals; Calcium Signaling; Collagen Type I; Fibrosis; Gene Expression Regulation; Humans; Hydrogels; Mechanotransduction, Cellular; Mice; Myofibroblasts; Polyethylene Glycols; Swine; Triazoles; TRPV Cation Channels; Viscoelastic Substances

2020
Inhibition of Fibrosis to Combat Lymphedema.
    Lymphatic research and biology, 2020, Volume: 18, Issue:5

    Topics: Aniline Compounds; Animals; Fibrosis; Lymphedema; Mice; Receptor, Transforming Growth Factor-beta Type I; Transforming Growth Factors; Triazoles

2020
BET-bromodomain inhibitors modulate epigenetic patterns at the diacylglycerol kinase alpha enhancer associated with radiation-induced fibrosis.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2017, Volume: 125, Issue:1

    Topics: Acetylation; Aged; Azepines; Bleomycin; Diacylglycerol Kinase; Enhancer Elements, Genetic; Epigenesis, Genetic; Female; Fibroblasts; Fibrosis; Humans; Middle Aged; Proteins; Radiation Injuries; Skin; Triazoles

2017
Dipeptidyl peptidase 4 inhibitor attenuates obesity-induced myocardial fibrosis by inhibiting transforming growth factor-βl and Smad2/3 pathways in high-fat diet-induced obesity rat model.
    Metabolism: clinical and experimental, 2017, Volume: 76

    Topics: Animals; Blood Glucose; Diet, High-Fat; Dipeptidyl-Peptidase IV Inhibitors; Fibrosis; Insulin; Lipid A; Male; Myocardium; Obesity; Rats; Rats, Inbred SHR; Signal Transduction; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta1; Triazoles

2017
BET-inhibition by JQ1 alleviates streptozotocin-induced diabetic cardiomyopathy.
    Toxicology and applied pharmacology, 2018, 08-01, Volume: 352

    Topics: Animals; Azepines; Caveolin 1; Cell Differentiation; Cell Movement; Cell Proliferation; Collagen; Cytoprotection; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Fibrosis; Male; Mice; Myocytes, Cardiac; Myofibroblasts; Proteins; Signal Transduction; Streptozocin; Transforming Growth Factor beta1; Triazoles; Ventricular Remodeling

2018
EW-7197, an oral transforming growth factor β type I receptor kinase inhibitor, for preventing peritoneal adhesion formation in a rat model.
    Surgery, 2018, Volume: 164, Issue:5

    Topics: Administration, Oral; Aniline Compounds; Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Epithelial-Mesenchymal Transition; Female; Fibrosis; Humans; Peritoneal Diseases; Peritoneum; Postoperative Complications; Protein Kinase Inhibitors; Rats; Rats, Wistar; Receptor, Transforming Growth Factor-beta Type I; Signal Transduction; Surgical Procedures, Operative; Tissue Adhesions; Treatment Outcome; Triazoles

2018
EW-7197 prevents ulcerative colitis-associated fibrosis and inflammation.
    Journal of cellular physiology, 2019, Volume: 234, Issue:7

    Topics: Aniline Compounds; Animals; Anti-Inflammatory Agents; Antioxidants; Colitis, Ulcerative; Colon; Fibrosis; Inflammation; Male; Mice, Inbred C57BL; Oxidative Stress; Triazoles

2019
AXL targeting reduces fibrosis development in experimental unilateral ureteral obstruction.
    Physiological reports, 2019, Volume: 7, Issue:10

    Topics: Animals; Axl Receptor Tyrosine Kinase; Benzocycloheptenes; Disease Models, Animal; Epithelial-Mesenchymal Transition; Extracellular Matrix Proteins; Fibrosis; Gene Expression Regulation; Inflammation Mediators; Kidney; Kidney Diseases; Macrophages; Male; Mice, Inbred C57BL; Myofibroblasts; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Signal Transduction; Triazoles; Ureteral Obstruction

2019
Bromodomain-containing protein 4 contributes to renal fibrosis through the induction of epithelial-mesenchymal transition.
    Experimental cell research, 2019, 10-15, Volume: 383, Issue:2

    Topics: Animals; Azepines; Case-Control Studies; Cell Cycle Proteins; Cells, Cultured; Disease Models, Animal; Disease Progression; Epithelial-Mesenchymal Transition; Fibrosis; Humans; Hypertension, Renal; Kidney; Male; Mice; Mice, Inbred C57BL; Nephritis; Nuclear Proteins; Transcription Factors; Triazoles

2019
A Novel Platelet-Activating Factor Receptor Antagonist Inhibits Choroidal Neovascularization and Subretinal Fibrosis.
    PloS one, 2013, Volume: 8, Issue:6

    Topics: Animals; Azepines; Choroidal Neovascularization; Disease Models, Animal; Female; Fibrosis; Hematologic Agents; Lasers; Macrophages; Mice, Inbred C57BL; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Retinal Diseases; RNA, Messenger; Triazoles

2013
Sitagliptin reduces cardiac apoptosis, hypertrophy and fibrosis primarily by insulin-dependent mechanisms in experimental type-II diabetes. Potential roles of GLP-1 isoforms.
    PloS one, 2013, Volume: 8, Issue:10

    Topics: Animals; Apoptosis; Cardiomegaly; Cardiotonic Agents; Cells, Cultured; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Disease Models, Animal; Drug Evaluation, Preclinical; Fibroblasts; Fibronectins; Fibrosis; Glucagon-Like Peptide 1; Glucose Intolerance; Hypoglycemic Agents; Insulin; Male; Metformin; Myocardium; Myocytes, Cardiac; PPAR delta; Protein Isoforms; Pyrazines; Rats; Sitagliptin Phosphate; Triazoles

2013
Inhibition of casein kinase II reduces TGFβ induced fibroblast activation and ameliorates experimental fibrosis.
    Annals of the rheumatic diseases, 2015, Volume: 74, Issue:5

    Topics: Adult; Aged; Animals; Casein Kinase II; Disease Models, Animal; Female; Fibroblasts; Fibrosis; Humans; Janus Kinase 2; Male; Mice; Middle Aged; Scleroderma, Systemic; Signal Transduction; Skin; STAT3 Transcription Factor; Transforming Growth Factor beta; Triazoles; Young Adult

2015
Activation of platelet-activating factor receptor exacerbates renal inflammation and promotes fibrosis.
    Laboratory investigation; a journal of technical methods and pathology, 2014, Volume: 94, Issue:4

    Topics: Animals; Azepines; Collagen; Disease Models, Animal; Fibrosis; Kidney; Mice; Mice, Inbred BALB C; Mice, Knockout; Nephritis; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Renal Insufficiency, Chronic; Triazoles; Ureteral Obstruction

2014
Dipeptidyl peptidase inhibition prevents diastolic dysfunction and reduces myocardial fibrosis in a mouse model of Western diet induced obesity.
    Metabolism: clinical and experimental, 2014, Volume: 63, Issue:8

    Topics: Animals; Cardiomyopathies; Diastole; Diet; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Fibrosis; Male; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Obesity; Triazoles

2014
EW-7197 inhibits hepatic, renal, and pulmonary fibrosis by blocking TGF-β/Smad and ROS signaling.
    Cellular and molecular life sciences : CMLS, 2015, Volume: 72, Issue:10

    Topics: Aniline Compounds; Animals; Bleomycin; Blotting, Western; Carbon Tetrachloride; Cell Line; Chromatin Immunoprecipitation; DNA Primers; Fibrosis; Fluorescent Antibody Technique; Humans; Immunohistochemistry; Kidney; Liver; Lung; Mice; Microarray Analysis; Protein Serine-Threonine Kinases; Rats; Reactive Oxygen Species; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; RNA, Small Interfering; Signal Transduction; Smad Proteins; Triazoles

2015
Association between renal iron accumulation and renal interstitial fibrosis in a rat model of chronic kidney disease.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2015, Volume: 38, Issue:7

    Topics: Animals; Benzoates; Blood Pressure; Deferasirox; Fibrosis; Gene Expression; Iron; Iron Chelating Agents; Kidney; Male; Nephrectomy; Nephritis, Interstitial; Proteinuria; Rats; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; Triazoles

2015
Inhibition of dipeptidyl peptidase IV protects tacrolimus-induced kidney injury.
    Laboratory investigation; a journal of technical methods and pathology, 2015, Volume: 95, Issue:10

    Topics: Animals; Antioxidants; Apoptosis; Biomarkers; Calcineurin Inhibitors; Diet, Sodium-Restricted; Dipeptidyl-Peptidase IV Inhibitors; Dose-Response Relationship, Drug; Fibrosis; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Immunosuppressive Agents; Kidney; Male; Oxidative Stress; Random Allocation; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; Tacrolimus; Triazoles

2015
Chelation efficacy and erythroid response during deferasirox treatment in patients with myeloproliferative neoplasms in fibrotic phase.
    European journal of haematology, 2016, Volume: 96, Issue:6

    Topics: Aged; Benzoates; Chelation Therapy; Deferasirox; Erythrocyte Indices; Erythropoiesis; Female; Fibrosis; Follow-Up Studies; Humans; Iron Chelating Agents; Iron Overload; Male; Middle Aged; Myeloproliferative Disorders; Retrospective Studies; Transfusion Reaction; Treatment Outcome; Triazoles

2016
Inhibition of Dipeptidyl Peptidase-4 Impairs Ventricular Function and Promotes Cardiac Fibrosis in High Fat-Fed Diabetic Mice.
    Diabetes, 2016, Volume: 65, Issue:3

    Topics: Animals; Cardiomegaly; Cytokines; Diabetes Mellitus, Experimental; Diet, High-Fat; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Fibrosis; Heart; Heart Failure; Hypoglycemic Agents; Immunoblotting; Inflammation; Liraglutide; Mice; Mice, Knockout; Myocardium; RNA, Messenger; Transcriptome; Triazoles; Ventricular Function; Ventricular Remodeling

2016
Brd4 inhibition attenuates unilateral ureteral obstruction-induced fibrosis by blocking TGF-β-mediated Nox4 expression.
    Redox biology, 2017, Volume: 11

    Topics: Actins; Animals; Antioxidants; Azepines; Cell Cycle Proteins; Cell Line, Transformed; Collagen Type IV; Epithelial Cells; Fibronectins; Fibrosis; Humans; Kidney; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NADPH Oxidase 4; Nuclear Proteins; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; RNA, Small Interfering; Smad3 Protein; Transcription Factors; Transforming Growth Factor beta1; Triazoles; Ureteral Obstruction

2017
Adenosine A(2A) receptor activation prevents progressive kidney fibrosis in a model of immune-associated chronic inflammation.
    Kidney international, 2011, Volume: 80, Issue:4

    Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Anti-Inflammatory Agents; Autoantibodies; Disease Models, Animal; Extracellular Matrix Proteins; Fibrosis; Glomerulonephritis; Inflammation Mediators; Kidney; Macrophages; Male; Phenethylamines; Rats; Rats, Inbred WKY; Receptor, Adenosine A2A; Severity of Illness Index; Time Factors; Triazines; Triazoles

2011
Effects of DPP-4 inhibition on cardiac metabolism and function in mice.
    Journal of molecular and cellular cardiology, 2011, Volume: 51, Issue:6

    Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinases; Animals; Body Weight; CD36 Antigens; Cell Membrane; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Fibrosis; Glucose Tolerance Test; Glucose Transporter Type 4; Glycation End Products, Advanced; Guanine; Heart; Insulin; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Phosphorylation; Protein Transport; Pyrazines; Sitagliptin Phosphate; Triazoles; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Protein p53; Tumor Suppressor Proteins

2011
Carboxyamidotriazole ameliorates experimental colitis by inhibition of cytokine production, nuclear factor-κB activation, and colonic fibrosis.
    The Journal of pharmacology and experimental therapeutics, 2012, Volume: 342, Issue:2

    Topics: Animals; Colitis; Colon; Dextran Sulfate; Fibrosis; Inflammation; Inflammatory Bowel Diseases; Intercellular Adhesion Molecule-1; Interleukin-1beta; Interleukin-6; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C57BL; Mucous Membrane; NF-kappa B; Phosphorylation; Proteolysis; Triazoles; Tumor Necrosis Factor-alpha

2012
Synthesis and biological evaluation of novel 2-pyridinyl-[1,2,3]triazoles as inhibitors of transforming growth factor beta 1 type 1 receptor.
    Bioorganic & medicinal chemistry letters, 2004, May-17, Volume: 14, Issue:10

    Topics: Activin Receptors, Type I; Binding Sites; Cell Line, Tumor; Dose-Response Relationship, Drug; Fibrosis; Genes, Reporter; Humans; Luciferases; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Structure-Activity Relationship; Transcription, Genetic; Transfection; Transforming Growth Factor beta; Triazoles

2004
Adenosine A2A receptors in diffuse dermal fibrosis: pathogenic role in human dermal fibroblasts and in a murine model of scleroderma.
    Arthritis and rheumatism, 2006, Volume: 54, Issue:8

    Topics: Animals; Cells, Cultured; Collagen; Dermis; Disease Models, Animal; Enzyme Inhibitors; Fibroblasts; Fibrosis; Gene Expression; Humans; Hydroxyproline; Male; MAP Kinase Kinase 1; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptor, Adenosine A2A; RNA, Messenger; Scleroderma, Diffuse; Triazines; Triazoles

2006
Pharmacological blockade of A2A receptors prevents dermal fibrosis in a model of elevated tissue adenosine.
    The American journal of pathology, 2008, Volume: 172, Issue:6

    Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Collagen; Fibrosis; Interleukin-13; Mice; Receptor, Adenosine A2A; Skin; Transforming Growth Factor beta1; Triazines; Triazoles

2008