triazoles has been researched along with pentylenetetrazole in 35 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (28.57) | 18.7374 |
| 1990's | 5 (14.29) | 18.2507 |
| 2000's | 8 (22.86) | 29.6817 |
| 2010's | 9 (25.71) | 24.3611 |
| 2020's | 3 (8.57) | 2.80 |
| Authors | Studies |
|---|---|
| Gall, M; Hester, JB; Lahti, RA; Rudzik, AD | 1 |
| Chidester, C; Duchamp, DJ; Gall, M; Lahti, RA; Rudzik, AD; Scahill, T | 1 |
| Auyong, TK; Chaudhari, A; Chaudhary, M; Chaudhary, SK; Parmar, SS | 1 |
| Kamdar, BV; Moffett, RB; Von Voigtlander, PF | 1 |
| Ashton, D; Clincke, GH; Fransen, J; Heeres, J; Janssen, PA | 1 |
| Bastide, J; Bastide, P; Coudert, P; Couquelet, JM; Rubat, C; Tronche, P | 1 |
| Gupta, AK; Gupta, TK; Parmar, SS; Singh, HH | 1 |
| Horiuchi, M; Ibii, N; Yamamoto, K | 1 |
| Beer, B; Lippa, AS; Meyerson, LR | 1 |
| Benjamin, L; Fryer, RI; Trybulski, EJ; Vitone, S; Walser, A | 1 |
| Kadaba, PK | 1 |
| Caliş, U; Demirdamar, R; Erol, DD; Ertan, M; Yuluğ, N | 1 |
| Ekinci, AC; Ergenç, N; Ulusoy, N | 1 |
| Caccia, S; Cagnotto, A; Fracasso, C; Ghia, M; Grossi, G; Mennini, T; Nacca, A; Roma, G | 1 |
| Brackenborough, KT; Duffy, C; Hagan, RM; Jones, SA; Morgan, PF; Pratt, GD; Sargent, RS; Southam, E; Stratton, SC | 1 |
| Akbarzadeh, T; Khoshnoud, MJ; Shafaghi, B; Shafiee, A; Tabatabai, SA | 1 |
| BALLONOFF, LB; FEINSTEIN, RN; SEAHOLM, JE | 1 |
| Reddy, DS | 1 |
| Altuğ, T; Bayrak, I; Güniz Küçükgüzel, S; Küçükgüzel, I; Otük-Saniş, G; Ozdemir, O; Rollas, S; Stables, JP | 1 |
| Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N | 1 |
| Atack, JR; Bristow, L; Bromidge, F; Carling, R; Castro, JL; Cook, SM; Dawson, GR; Kerby, J; McKernan, RM; Melillo, D; Pike, A; Ragan, I; Sohal, B; Street, L; Sur, C; Tye, SJ; Wafford, KA; Whiting, P | 1 |
| Chai, KY; Jin, YZ; Li, FN; Li, G; Quan, ZS; Sun, XY | 1 |
| Cormack, LK; Feinberg, LM; Schallert, K; Schallert, T; Spinetta, MJ; Stroud, C; Woodlee, MT | 1 |
| Deng, XQ; Quan, LN; Quan, ZS; Song, MX; Wei, CX | 1 |
| Li, W; Zhang, JJ | 1 |
| Han, RB; Peng, B; Piao, FY; Zhang, W; Zhang, WB | 1 |
| Cao, X; Liu, DC; Quan, ZS; Shu, B; Wang, SB; Zheng, Y | 1 |
| Ahmadi, F; Banafshe, HR; Mahmoodi, B; Mashayekh, S; Motaharian, D; Navidpour, L; Rahmanipour, N; Shafaroodi, H; Shafiee, A; Shahhosseini, S | 1 |
| Guan, LP; Jin, P; Li, FN; Quan, ZS; Wang, SB; Zhang, HJ | 1 |
| Panda, BP; Rashid, D; Vohora, D | 1 |
| Ahangar, N; Dehestani, L; Emami, S; Hashemi, SM; Honarchian Masihi, P; Irannejad, H; Shakiba, A | 1 |
| Huang, LJ; Peng, Y; Peng, YC; Wang, S; Wang, XL; Zhang, Y | 1 |
| Jain, J; Singh, UK; Verma, KK | 1 |
| Chen, L; Hou, Z; Huang, L; Li, X; Lian, C; Meng, Q; Wang, Y; Wu, J; Yu, H; Zhang, C | 1 |
| Abou-Krisha, MM; Alhamzani, AG; Jeon, BH; Prashanth, MK; Raghu, MS; Yogesh Kumar, K; Yousef, TA | 1 |
1 review(s) available for triazoles and pentylenetetrazole
| Article | Year |
|---|---|
Molecular substrates of anxiety: clues from the heterogeneity of benzodiazepine receptors.
Topics: Aging; Animals; Anxiety; Benzodiazepines; Binding, Competitive; Brain; Carbolines; Chemical Phenomena; Chemistry, Physical; Flunitrazepam; Humans; Muscles; Pentylenetetrazole; Pyridazines; Receptors, Drug; Receptors, GABA-A; Tissue Distribution; Triazoles | 1982 |
34 other study(ies) available for triazoles and pentylenetetrazole
| Article | Year |
|---|---|
Synthesis and pharmacology of novel anxiolytic agents derived from 2-[(dialkylamino)methyl-4H-triazol-4-yl] benzophenones and related heterocyclic benzophenones.
Topics: Animals; Anti-Anxiety Agents; Benzophenones; Drug Synergism; Electroshock; Ethanol; Male; Mice; Nicotine; Pentylenetetrazole; Semicarbazides; Strychnine; Triazoles | 1976 |
Novel anxiolytic agents derived from alpha-amino-alpha-phenyl-o-tolyl-4H-triazoles and -imidazoles.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Brain; Crystallography; Hypnotics and Sedatives; Imidazoles; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Mice; Models, Molecular; Molecular Conformation; Muscle Relaxation; Nicotine; Pentylenetetrazole; Rats; Seizures; Semicarbazides; Triazoles | 1978 |
Anticonvulsant activity of newer substituted methylenedioxyphenyl mercaptotriazoles.
Topics: Animals; Anticonvulsants; Brain; Depression, Chemical; Female; In Vitro Techniques; Male; Mice; Oxygen Consumption; Pentylenetetrazole; Rats; Sulfhydryl Compounds; Triazoles | 1976 |
Central nervous system depressants. 13. s-Triazolo-1,5-benzodiazepin-5-ones.
Topics: Animals; Benzodiazepinones; Central Nervous System; Depression, Chemical; Male; Mice; Nicotine; Pentylenetetrazole; Reflex; Seizures; Strychnine; Triazoles | 1976 |
In vivo studies on the mechanism of action of the broad spectrum anticonvulsant loreclezole.
Topics: Animals; Anticonvulsants; Diazepam; Electric Stimulation; Kindling, Neurologic; Male; Pentobarbital; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Triazoles | 1992 |
Synthesis and pharmacological evaluation of 6,8-diaryl 1,2,4-triazolo [4,3,-b] and 1,2,3,4,-tetrazolo [1,5-b] pyridazines.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Azoles; Behavior, Animal; Bicuculline; Chemical Phenomena; Chemistry; Electroshock; Hypnotics and Sedatives; Mice; Motor Activity; Pentylenetetrazole; Pyridazines; Seizures; Tetrazoles; Triazoles | 1990 |
Benzimidazolyl-1,2,4(H)-triazoles as central nervous system depressants.
Topics: Animals; Anticonvulsants; Behavior, Animal; Benzimidazoles; Central Nervous System; Depression, Chemical; Female; Lethal Dose 50; Male; Mice; Motor Activity; Pentobarbital; Pentylenetetrazole; Sleep; Structure-Activity Relationship; Triazoles | 1972 |
[Pharmacology of a 1H-1, 2, 4-triazolyl benzophenone derivative (450191-S), a new sleep-inducer (III). Behavioral study on interactions of 450191-S and other drugs in mice].
Topics: Aminopyrine; Animals; Anti-Anxiety Agents; Apomorphine; Behavior, Animal; Benzodiazepines; Central Nervous System; Central Nervous System Agents; Haloperidol; Hypnotics and Sedatives; Imipramine; Male; Mice; Pentylenetetrazole; Phenytoin; Reserpine; Triazoles | 1984 |
2-Benzazepines. 4. [1,2,3]Triazolo[4,5-d][2]benzazepines and dibenzo[c,f][1,2,3]triazolo[3,4-a]azepines: synthesis and evaluation as central nervous system agents.
Topics: Animals; Behavior, Animal; Chemical Phenomena; Chemistry; Diazepam; Dibenzazepines; Pentylenetetrazole; Postural Balance; Triazoles | 1983 |
Triazolines XIII: delta 2-1,2,3-triazolines, a new class of anticonvulsants.
Topics: Animals; Anticonvulsants; Behavior, Animal; Chemical Phenomena; Chemistry; Electroshock; Male; Mice; Pentylenetetrazole; Structure-Activity Relationship; Triazoles | 1984 |
Synthesis and biological activities of some 3,6-disubstituted thiazolo[3,2-b][1,2,4]triazoles.
Topics: Animals; Anticonvulsants; Antifungal Agents; Candida; Electroshock; Male; Mice; Microbial Sensitivity Tests; Pentylenetetrazole; Seizures; Spectrophotometry, Infrared; Thiazoles; Triazoles | 1995 |
Synthesis and anticonvulsant activity of some new 1,1-bis(4-substituted 1,2,4-triazoline-5-thione-3-yl)-2-methylbutanes.
Topics: Animals; Anticonvulsants; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Mice; Pentylenetetrazole; Seizures; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Thiones; Triazoles | 1995 |
Acid-catalysed hydrolysis and benzodiazepine-like properties of 5-(dialkylamino)- and 5-(alkylthio)-substituted 8-chloro-6-phenyl-6H-[1,2,4]triazolol[4,3-a][1,5]benzodiazepines in mice.
Topics: Administration, Oral; Animals; Anticonvulsants; Benzodiazepines; Brain; Gastric Acid; Hydrolysis; Male; Mice; Pentylenetetrazole; Receptors, GABA-A; Seizures; Triazoles | 1998 |
Broad spectrum anticonvulsant activity of BW534U87: possible role of an adenosine-dependent mechanism.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Amygdala; Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Electroshock; Enzyme Inhibitors; Female; Kindling, Neurologic; Male; Mice; Pentylenetetrazole; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Seizures; Triazoles; Xanthines | 2002 |
Design and synthesis of 4H-3-(2-phenoxy)phenyl-1,2,4-triazole derivatives as benzodiazepine receptor agonists.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Drug Design; GABA-A Receptor Agonists; Indicators and Reagents; Magnetic Resonance Spectroscopy; Mice; Models, Molecular; Molecular Conformation; Pentylenetetrazole; Postural Balance; Seizures; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Triazoles | 2003 |
EFFECT ON CATALASE IN VIVO AND IN VITRO OF COMPOUNDS RELATED TO AMINOTRIAZOLE. ANL-6823.
Topics: Amitrole; Azides; Azoles; Catalase; Enzyme Inhibitors; Erythrocytes; Imidazoles; In Vitro Techniques; Isoniazid; Kidney; Liver; Oxadiazoles; Oxazoles; Oxidation-Reduction; Pentylenetetrazole; Pharmacology; Pyrazoles; Rats; Research; Thiazoles; Triazoles | 1964 |
Testosterone modulation of seizure susceptibility is mediated by neurosteroids 3alpha-androstanediol and 17beta-estradiol.
Topics: Androstane-3,17-diol; Animals; Aromatase Inhibitors; Chromatography; Convulsants; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estradiol; Finasteride; Hippocampus; Letrozole; Male; Mass Spectrometry; Mice; Nitriles; Organ Culture Techniques; Patch-Clamp Techniques; Pentylenetetrazole; Rats; Receptors, GABA-A; Seizures; Testosterone; Triazoles | 2004 |
Synthesis of some 3-(arylalkylthio)-4-alkyl/aryl-5-(4-aminophenyl)-4H-1,2,4-triazole derivatives and their anticonvulsant activity.
Topics: Animals; Anti-Bacterial Agents; Anticonvulsants; Antifungal Agents; Drug Evaluation, Preclinical; Electroshock; Male; Mice; Mice, Inbred BALB C; Mycobacterium tuberculosis; Pentylenetetrazole; Rats; Rotarod Performance Test; Survival Rate; Triazoles | 2004 |
Pharmacodynamic and/or pharmacokinetic characteristics of interactions between loreclezole and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice: an isobolographic analysis.
Topics: Animals; Anticonvulsants; Clonazepam; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Ethosuximide; Kindling, Neurologic; Linear Models; Male; Mice; Pentylenetetrazole; Phenobarbital; Seizures; Triazoles; Valproic Acid | 2005 |
TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for alpha2- and alpha3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primates.
Topics: Acoustic Stimulation; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Anti-Anxiety Agents; Anticonvulsants; Autoradiography; Conditioning, Operant; Convulsants; Drinking; Emotions; Fear; Flumazenil; GABA Modulators; GABA-A Receptor Agonists; Humans; Male; Mice; Pentylenetetrazole; Postural Balance; Protein Binding; Pyridazines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Recombinant Proteins; Reflex, Startle; Saimiri; Substance Withdrawal Syndrome; Triazoles | 2006 |
Synthesis of 8-alkoxy-4,5-dihydro-[1,2,4]triazole[4,3-a]quinoline-1-ones and evaluation of their anticonvulsant properties.
Topics: Animals; Anticonvulsants; Convulsants; Electroshock; Epilepsy; Female; Indicators and Reagents; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Mice; Mice, Inbred C57BL; Pentylenetetrazole; Postural Balance; Quinolones; Spectrophotometry, Infrared; Triazoles | 2006 |
Alcohol-induced retrograde memory impairment in rats: prevention by caffeine.
Topics: Adenosine A2 Receptor Antagonists; Amnesia, Retrograde; Animals; Caffeine; Central Nervous System Depressants; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Drug Therapy, Combination; Ethanol; Exploratory Behavior; Habituation, Psychophysiologic; Injections, Intraperitoneal; Male; Odorants; Pentylenetetrazole; Phosphodiesterase 5 Inhibitors; Purinones; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Recognition, Psychology; Seizures; Smell; Time Factors; Triazines; Triazoles; Wood | 2008 |
Synthesis and anticonvulsant activity of 7-phenyl-6,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-ones and their derivatives.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bicuculline; Electroshock; Isoniazid; Mice; Pentylenetetrazole; Pyrimidinones; Seizures; Semicarbazides; Structure-Activity Relationship; Triazoles | 2011 |
[Sedative, hypnotic and anticonvulsive effects of an adenosine analogue WS090501].
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Anticonvulsants; Convulsants; Electroencephalography; Hypnotics and Sedatives; Male; Mice; Mice, Inbred ICR; Motor Activity; Pentylenetetrazole; Pyrimidines; Rats; Rats, Wistar; Seizures; Sleep; Triazoles; Xanthines | 2011 |
Synthesis and biological evaluation of 9-alkoxy-6,7-dihydro-5H-benzo[c] [1,2,4]triazolo[4,3-a]azepines as potential anticonvulsant agents.
Topics: Animals; Anticonvulsants; Azepines; Convulsants; Electroshock; Mice; Pentylenetetrazole; Postural Balance; Seizures; Spectrophotometry, Infrared; Structure-Activity Relationship; Triazoles | 2012 |
Design, synthesis and anticonvulsant activity evaluation of novel 4-(4-substitutedphenyl)-3-methyl-1H-1,2,4-triazol-5(4H)-ones.
Topics: Animals; Anticonvulsants; Carbamazepine; Convulsants; Drug Design; Drug Evaluation, Preclinical; Electroshock; Indicators and Reagents; Magnetic Resonance Spectroscopy; Mice; Pentylenetetrazole; Postural Balance; Seizures; Structure-Activity Relationship; Triazoles | 2014 |
Synthesis, receptor affinity and effect on pentylenetetrazole-induced seizure threshold of novel benzodiazepine analogues: 3-Substituted 5-(2-phenoxybenzyl)-4H-1,2,4-triazoles and 2-amino-5-(phenoxybenzyl)-1,3,4-oxadiazoles.
Topics: Animals; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred Strains; Models, Molecular; Molecular Structure; Oxadiazoles; Pentylenetetrazole; Receptors, GABA-A; Seizures; Structure-Activity Relationship; Triazoles | 2014 |
Synthesis and Anticonvulsant Activity Evaluation of 4-Phenyl-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one and Its Derivatives.
Topics: Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Brain; Disease Models, Animal; Drug Design; Electroshock; Mice; Molecular Structure; Motor Activity; Pentylenetetrazole; Quinazolinones; Rotarod Performance Test; Seizures; Structure-Activity Relationship; Time Factors; Triazoles | 2015 |
Reduced estradiol synthesis by letrozole, an aromatase inhibitor, is protective against development of pentylenetetrazole-induced kindling in mice.
Topics: Animals; Anticonvulsants; Aromatase Inhibitors; Convulsants; Dose-Response Relationship, Drug; Estradiol; Kindling, Neurologic; Letrozole; Male; Mice; Neurotransmitter Agents; Nitriles; Pentylenetetrazole; Triazoles | 2015 |
Design, synthesis, in vivo and in silico evaluation of phenacyl triazole hydrazones as new anticonvulsant agents.
Topics: Animals; Anticonvulsants; Biological Availability; Drug Design; Hydrazones; Injections, Intraperitoneal; Male; Mice; Molecular Docking Simulation; Molecular Structure; Motor Activity; Pentylenetetrazole; Seizures; Triazoles | 2018 |
Hsp90β inhibitors prevent GLT-1 degradation but have no beneficial efficacy on absence epilepsy.
Topics: Animals; Anticonvulsants; Benzoquinones; Epilepsy, Absence; Excitatory Amino Acid Transporter 2; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hippocampus; HSP90 Heat-Shock Proteins; Lactams, Macrocyclic; Mice; Pentylenetetrazole; Triazoles | 2019 |
Screening of Some Novel 4, 5 Disubstituted 1, 2, 4-Triazole-3-thiones for Anticonvulsant Activity.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Ataxia; Convulsants; Drug Evaluation, Preclinical; Electroshock; Male; Mice; Molecular Docking Simulation; Pentylenetetrazole; Rotarod Performance Test; Seizures; Structure-Activity Relationship; Triazoles | 2020 |
Discovery of 7-alkyloxy- [1,2,4] triazolo[1,5-a] pyrimidine derivatives as selective positive modulators of GABA
Topics: Animals; Anticonvulsants; Cells, Cultured; Dose-Response Relationship, Drug; Drug Discovery; Electroshock; Epilepsy; Male; Mice; Mice, Inbred Strains; Molecular Structure; Neurons; Pentylenetetrazole; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Structure-Activity Relationship; Triazoles | 2022 |
Design, synthesis, molecular docking and pharmacological evaluation of novel triazine-based triazole derivatives as potential anticonvulsant agents.
Topics: Anticonvulsants; Electroshock; Humans; Molecular Docking Simulation; Molecular Structure; Pentylenetetrazole; Seizures; Structure-Activity Relationship; Triazines; Triazoles | 2022 |