Leukoencephalopathy, Progressive Multifocal

An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. (From Joynt, Clinical Neurology, 1996, Ch26, pp36-7)

Synonym
Leukoencephalopathy, Progressive Multifocal

Excerpt	Reference
"(Progressive Multifocal Leukoencephalopathy) is described."	( Bots, GT; Speelman, JD; Stam, J; ter Schegget, J; Verbeeten, B, 1985)
"Progressive multifocal leukoencephalopathy is a viral-induced demyelinating disease of the central nervous system usually occurring in the immunocompromised individual."	( Ault, GS; Major, EO, 1995)
"Progressive multifocal leukoencephalopathy is a fatal demyelinating disease of the central nervous system frequently seen in patients with impaired immune systems, particularly acquired immunodeficiency syndrome."	( Amini, S; Del Valle, L; Enam, S; Khalili, K; Sweet, TM, 2004)
"Progressive multifocal leukoencephalopathy is an infectious demyelinating brain disease caused by the JC virus that is associated with significant morbidity and mortality in the immunocompromised host."	( Abrams, EJ; Ainyette, I; Champion, SE; Chiriboga, CA; DiGrado, M; Robinson, LG, 2004)
"Progressive multifocal leukoencephalopathy is a progressive and ultimately fatal white-matter disease of the brain that is associated with polyomavirus infection."	( Ellis, EN; Jacobs, R; Phillips, T, 2004)
"Progressive multifocal leukoencephalopathy is a rare, highly fatal demyelinating brain infection caused by the JC virus."	( Bennett, K; McCalmont, V, 2007)
"Progressive multifocal leukoencephalopathy is a demyelinating disease with a high mortality caused by the JC virus and occurs in about 5% of HIV-infected patients."	( Arendt, G; Evers, S; Husstedt, IW; Kraemer, C; Nolting, T, 2008)
"Progressive multifocal leukoencephalopathy is a neurological disease caused by the human polyoma virus JC virus and can present in patients with known immunodeficiencies."	( Ikwuagwu, J; Patel, A; Patel, J, 2010)
"Progressive multifocal leukoencephalopathy is a rare but fatal brain infection caused by John Cunningham (JC) virus and has been associated with natalizumab use."	( Bellaguarda, E; Cohen, RD; Keyashian, K; Pekow, J; Rubin, DT; Sakuraba, A, 2015)
"Progressive multifocal leukoencephalopathy is a severe demyelinating disease caused by the polyoma JC virus in patients with reduced immunocompetence."	( Bischof, F; Bornemann, A; Dammeier, N; Hauser, TK; Schubert, V, 2015)
"Progressive multifocal leukoencephalopathy is infrequently linked to FAE treatment, but underreporting cannot be excluded."	( Balak, DMW; Bramer, WM; Hajdarbegovic, E; Neumann, HAM; Thio, HB, 2017)

Excerpt	Reference
"The incidence of progressive multifocal leukoencephalopathy has risen sharply over the past decade because of widespread human immunodeficiency virus infection leading to immunodeficiency."	( Ault, GS; Major, EO, 1995)
"A few cases of progressive multifocal leukoencephalopathy have been reported in patients treated with fumaric acid esters."	( Bischof, F; Bornemann, A; Dammeier, N; Hauser, TK; Schubert, V, 2015)

Excerpt	Reference
"Progressive multifocal leukoencephalopathy affects about 4 percent of patients with the acquired immunodeficiency syndrome (AIDS), and survival after the diagnosis of leukoencephalopathy averages only about three months."	( Clifford, D; Cohen, B; Dafni, U; Hall, CD; Hollander, H; Major, E; McArthur, J; Millar, L; Simpson, D; Timpone, J; Wetherill, PE; Yainnoutsos, C, 1998)

Excerpt	Reference
"This is the first report of successful treatment of progressive multifocal leukoencephalopathy with mefloquine."	( Al-Khotani, A; Ang, LC; Gofton, TE; McLachlan, RS; O'Farrell, B, 2011)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	86 (11.42)	23.3326
1990's	174 (23.11)	12.5806
2000's	192 (25.50)	18.1394
2010's	233 (30.94)	28.8240
2020's	68 (9.03)	9.53

Drug	Relationship Strength	Studies	Trials
adenine	low	7	0
betaine	low	1	0
carbon monoxide	low	1	0
choline	low	11	0
salicylic acid	low	1	0
creatine	low	8	0
cytosine	medium	69	5
lactic acid	low	4	0
dimethyl sulfoxide	low	1	0
formaldehyde	low	2	0
glutaric acid	low	1	0
glycerol	low	1	0
hydrogen	low	1	0
iodine	low	1	0
methanol	low	1	0
inositol	low	4	0
uric acid	low	1	0
phenytoin	low	1	0
acetazolamide	low	1	0
albendazole	low	1	0
azathioprine	low	14	0
carbamazepine	low	1	0
carmofur	low	5	0
carmustine	medium	3	1
chlorambucil	low	8	0
chlorpromazine	low	3	0
citalopram	low	1	0
dapsone	low	1	0
pentetic acid	low	2	0
flufenamic acid	low	1	0
flumazenil	low	1	0
fluorouracil	low	19	0
foscarnet	low	1	0
gentamicin	low	1	0
haloperidol	low	1	0
hydroxychloroquine	low	2	0
ifosfamide	low	1	0
imipramine	low	1	0
ketanserin	low	1	0
beta-lapachone	low	2	0
leflunomide	low	5	0
lomustine	low	1	0
mechlorethamine	low	1	0
mefenamic acid	low	1	0
mianserin	medium	33	1
midazolam	low	1	0
mirtazapine	medium	51	1
mitoxantrone	low	2	0
nimodipine	low	1	0
nitrazepam	low	1	0
procarbazine	low	2	0
propanil	low	1	0
propidium	low	1	0
pyrimethamine	low	1	0
risperidone	low	6	0
ritanserin	low	3	0
sobuzoxane	low	1	0
sulfasalazine	low	1	0
tegafur	low	3	0
temozolomide	low	1	0
thalidomide	low	2	0
thiotepa	low	1	0
prednisolone	low	12	0
prednisone	low	23	0
idoxuridine	low	1	0
serine	low	1	0
aspartic acid	low	9	0
glutamine	low	2	0
cephalothin	low	1	0
carbostyril	low	1	0
leucine	low	1	0
methionine	low	4	0
phenylalanine	low	1	0
chloroform	low	1	0
cytarabine	medium	68	4
arginine	low	1	0
methylprednisolone	low	11	0
xanthone	low	1	0
thiophenes	low	1	0
meglumine	low	1	0
isoxazoles	low	5	0
thiazoles	low	6	0
chenodeoxycholic acid	low	1	0
podophyllotoxin	low	1	0
congo red	low	1	0
c.i. 42510	low	1	0
deoxycytidine	low	3	0
thioflavin t	low	1	0
stavudine	low	1	0
cladribine	medium	2	1
carbenicillin	low	1	0
vidarabine	low	17	0
technetium	low	1	0
gadolinium	low	16	0
gold	low	1	0
camptothecin	low	9	0
trolamine salicylate	low	2	0
levamisole	low	16	0
oxcarbazepine	low	1	0
zidovudine	low	16	0
paclitaxel	low	1	0
etoposide	low	5	0
flunixin meglumine	low	1	0
mefloquine	low	1	0
vindesine	low	1	0
nitazoxanide	medium	6	1
idarubicin	low	1	0
cidofovir anhydrous	medium	67	5
topotecan	medium	10	1
gemcitabine	low	2	0
aripiprazole	low	1	0
lamivudine	low	6	0
irinotecan	low	3	0
ziprasidone	low	2	0
capecitabine	low	1	0
diltiazem hydrochloride	low	1	0
efavirenz	low	2	0
n-acetylaspartic acid	low	9	0
triazoles	low	8	0
miconazole nitrate	low	1	0
fluorodeoxyglucose f18	low	9	0
voriconazole	low	1	0
ranimustine	low	1	0
bendamustine hydrochloride	low	4	0
lopinavir	low	2	0
diffractaic acid	low	1	0
mizoribine	low	1	0
artesunic acid	low	1	0
fingolimod hydrochloride	low	41	0
deoxyglucose	low	2	0
gadolinium 1,4,7,10-tetraazacyclododecane-n,n',n'',n'''-tetraacetate	low	1	0
imatinib mesylate	low	1	0
methotrexate	low	37	0
pomalidomide	low	1	0
n-acetyltalosaminuronic acid	low	1	0
atazanavir sulfate	low	1	0
biotin	low	2	0
organophosphonates	medium	69	5
etravirine	low	1	0
darunavir	low	2	0
lenalidomide	low	4	0
deoxycholic acid	low	1	0
bortezomib	low	1	0
ritonavir	low	3	0
carboplatin	low	3	0
n-acetylneuraminic acid	low	1	0
elastin	low	1	0
abacavir	low	2	0
fumaric acid	low	2	0
tacrolimus	low	9	0
cocaine	low	2	0
mycophenolic acid	low	13	0
h 89	low	1	0
wr-142,490	low	1	0
dactinomycin	low	1	0
melphalan	low	2	0
tenofovir	low	2	0
l 743,872	low	1	0
cmx 001	low	2	0
riboflavin	low	1	0
tolfenamic acid	low	1	0
dimethyl fumarate	low	23	0
buprenorphine	low	1	0
fludarabine	low	12	0
fusidic acid	low	1	0
ranitidine	low	1	0
maraviroc	low	11	0
nitrogen dioxide	low	1	0
naphthoquinones	low	2	0
myelin basic protein	low	6	0
diclofenac sodium	low	1	0
sphingosine	low	9	0
amphotericin b	low	3	0
harman	low	1	0
irisolidone	low	1	0
isotretinoin	low	1	0
sphingosine 1-phosphate	low	1	0
sirolimus	low	2	0
mdl 100907	low	5	0
indinavir sulfate	low	6	0
fumarates	low	20	0
cysteine	low	1	0
heroin	medium	3	1
gw-5074	low	1	0
everolimus	low	1	0
i(3)so3-galactosylceramide	low	1	0
gadolinium dtpa	low	2	0
staurosporine	low	1	0
mocetinostat	low	2	0
tofacitinib	low	2	0
idelalisib	low	1	0
technetium tc 99m exametazime	low	1	0
methylamphotericin b	low	1	0
mefloquine	medium	50	1
carbon-11 methionine	low	1	0
enfuvirtide	medium	1	1
oligonucleotides	low	3	0
phosphatidylcholines	low	1	0
calpain	low	1	0
raltegravir potassium	low	1	0
amphotericin b, deoxycholate drug combination	low	1	0
pci 32765	low	6	0
mk 2206	low	1	0
incb-018424	low	2	0
glycolipids	low	2	0
piperidines	low	7	0
abt-199	low	1	0
teriflunomide	low	5	0
epidermal growth factor	low	2	0
transforming growth factor beta	low	3	0
cyclin d1	low	1	0
calpastatin	low	1	0
vitamin b 12	low	2	0
cyclosporine	low	13	0
acyclovir	low	2	0
levoleucovorin	low	3	0
guanosine triphosphate	low	1	0
folic acid	low	1	0
rifampin	low	1	0
clozapine	low	1	0
dacarbazine	low	1	0
didanosine	low	2	0
ganciclovir	low	1	0
olanzapine	low	2	0
inosine pranobex	low	1	0
streptovaricin c	low	1	0
phosphorus radioisotopes	low	1	0
pyrimidinones	low	1	0

Protein Targets (2,177)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Luciferase	27	0	0	27
cytochrome P450 family 3 subfamily A polypeptide 4	49	0	0	49
cytochrome P450 2D6	35	0	0	35
euchromatic histone-lysine N-methyltransferase 2	58	0	0	58
peripheral myelin protein 22	39	0	0	39
Albumin	0	1	8	15
ATP-dependent translocase ABCB1	0	16	1	26
Replicase polyprotein 1ab	0	9	7	16
Replicase polyprotein 1ab	0	12	7	19
Reverse transcriptase/RNaseH	0	10	10	32
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	15	0	17
EWS/FLI fusion protein	57	0	0	57
Apoptosis regulator Bcl-2	0	3	2	5
Spike glycoprotein	34	2	6	42
Bcl-2-like protein 1	0	3	0	3
Induced myeloid leukemia cell differentiation protein Mcl-1	0	2	0	2
Aspartyl/asparaginyl beta-hydroxylase	0	1	0	1
Bcl-2-related protein A1	0	1	0	1
Bcl-2-like protein 2	0	1	0	1
Bcl2-associated agonist of cell death	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	26	0	0	26
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	13	0	0	13
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
thioredoxin reductase	38	0	0	38
GALC protein	8	0	0	8
GLI family zinc finger 3	55	0	0	55
nuclear receptor subfamily 1, group I, member 3	52	0	0	52
glucocorticoid receptor [Homo sapiens]	57	0	0	57
retinoic acid nuclear receptor alpha variant 1	49	0	0	49
retinoid X nuclear receptor alpha	50	0	0	50
estrogen-related nuclear receptor alpha	68	0	0	68
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
arylsulfatase A	25	0	0	25
Carbonic anhydrase	0	1	0	1
Bloom syndrome protein isoform 1	32	0	0	32
thyroid hormone receptor beta isoform a	21	0	0	21
nuclear factor erythroid 2-related factor 2 isoform 1	59	0	0	59
geminin	73	0	0	73
survival motor neuron protein isoform d	35	0	0	35
muscleblind-like protein 1 isoform 1	18	0	0	18
Gamma-aminobutyric acid receptor subunit pi	36	9	0	46
ATP-binding cassette sub-family C member 3	0	65	0	65
Multidrug resistance-associated protein 4	0	64	0	66
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 6	0	4	0	7
Carbonic anhydrase 12	0	7	1	11
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	1	0	2
Bile salt export pump	0	76	0	76
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	2	0	2
Carbonic anhydrase 1	0	11	1	21
Carbonic anhydrase 2	0	12	2	21
Carbonic anhydrase 2	0	2	0	2
Cytochrome P450 1A2	0	9	1	11
Carbonic anhydrase 3	0	5	1	9
Cathepsin B	0	1	0	1
Cytochrome P450 3A4	0	32	0	40
Steryl-sulfatase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	23	2	26
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Cytochrome P450 2C8	0	3	0	5
Cytochrome P450 2D6	0	17	1	19
Cytochrome P450 2A6	0	2	0	2
Cytochrome P450 2C9	0	24	0	26
5-hydroxytryptamine receptor 2A	0	25	2	28
Androgen receptor	0	6	0	6
Gamma-aminobutyric acid receptor subunit beta-1	36	9	0	46
Translocator protein	0	4	0	4
Gamma-aminobutyric acid receptor subunit delta	36	9	0	46
Gamma-aminobutyric acid receptor subunit gamma-2	36	9	0	46
Gamma-aminobutyric acid receptor subunit alpha-5	36	9	0	46
Gamma-aminobutyric acid receptor subunit alpha-3	36	9	0	46
Cannabinoid receptor 1	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Cytochrome P450 2B6	0	4	2	8
Carbonic anhydrase 4	0	6	1	9
Carbonic anhydrase 6	0	5	1	8
Gamma-aminobutyric acid receptor subunit gamma-1	36	9	0	46
Gamma-aminobutyric acid receptor subunit alpha-2	36	9	0	46
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Adenosine receptor A1	0	4	0	5
Serum paraoxonase/arylesterase 1	0	4	0	4
Dipeptidyl peptidase 4	0	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	36	9	0	46
Gamma-aminobutyric acid receptor subunit gamma-3	36	9	0	46
Endochitinase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	36	9	0	46
Adenosine receptor A2a	0	2	0	3
5-hydroxytryptamine receptor 2B	0	20	3	23
Sodium-dependent serotonin transporter	0	11	0	12
Delta-type opioid receptor	0	1	0	1
Cytochrome P450 2C19	0	12	0	15
Delta-type opioid receptor	0	4	0	4
Mu-type opioid receptor	0	3	0	3
Carbonic anhydrase 5A, mitochondrial	0	6	1	11
Carbonic anhydrase	0	1	0	2
Kappa-type opioid receptor	0	5	0	6
Carbonic anhydrase 7	0	5	1	8
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	7	2	0	9
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase	0	1	0	2
D(2) dopamine receptor	0	22	0	23
Gamma-aminobutyric acid receptor subunit alpha-1	36	9	0	46
Gamma-aminobutyric acid receptor subunit beta-3	36	9	0	46
Gamma-aminobutyric acid receptor subunit beta-2	36	9	0	46
Cholinesterase	0	2	0	2
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Fatty-acid amide hydrolase 1	0	3	0	3
Beta-carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	8	0	10
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	3	0	3
Carbonic anhydrase 9	0	8	1	12
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase	0	1	0	1
Sigma intracellular receptor 2	0	7	0	7
Delta carbonic anhydrase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	3	0	3
Renin	0	1	0	1
Carbonic anhydrase	0	1	0	2
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	4	1	7
GABA theta subunit	36	9	0	46
Canalicular multispecific organic anion transporter 1	0	65	0	66
Carbonic anhydrase 4	0	2	0	3
Carbonic anhydrase 15	0	3	0	5
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	3	0	5
Carbonic anhydrase 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	36	9	0	46
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 14	0	5	1	9
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	5	1	10
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	17	0	0	17
Chain B, HADH2 protein	17	0	0	17
Chain A, ATP-DEPENDENT DNA HELICASE Q1	10	0	0	10
Chain A, Ferritin light chain	27	0	0	27
Thymidine kinase	0	4	0	4
phosphopantetheinyl transferase	29	0	0	29
GLS protein	27	0	0	27
TDP1 protein	87	0	0	87
Smad3	20	0	0	20
thyroid stimulating hormone receptor	28	0	0	28
activating transcription factor 6	23	0	0	23
Histone H2A.x	27	0	0	27
hemoglobin subunit beta	6	0	0	6
atrial natriuretic peptide receptor 1 precursor	4	0	0	4
ubiquitin carboxyl-terminal hydrolase 2 isoform a	8	0	0	8
lamin isoform A-delta10	61	0	0	61
Solute carrier family 22 member 1	0	10	0	13
Bile salt export pump	0	16	0	16
Purine nucleoside phosphorylase	0	1	0	1
Thymidine kinase, cytosolic	0	5	0	9
POU domain, class 2, transcription factor 2	0	0	0	2
Cytochrome P450 2J2	0	10	0	11
Disintegrin and metalloproteinase domain-containing protein 17	5	1	0	6
Purine nucleoside phosphorylase	0	0	2	2
Solute carrier family 22 member 6	0	4	0	12
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	3	0	7
Thymidine kinase	0	2	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	33	0	0	33
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
RAR-related orphan receptor gamma	54	0	0	54
AR protein	71	0	0	71
pregnane X nuclear receptor	50	0	0	50
estrogen nuclear receptor alpha	84	0	0	84
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	35	0	0	35
nuclear factor erythroid 2-related factor 2 isoform 2	30	0	0	30
heat shock protein beta-1	16	0	0	16
importin subunit beta-1 isoform 1	6	0	0	6
snurportin-1	6	0	0	6
tumor susceptibility gene 101 protein	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
Voltage-dependent calcium channel gamma-2 subunit	32	0	0	32
Cyclin-dependent kinase 1	0	1	7	8
Heat shock protein HSP 90-beta	0	1	0	1
Glutamate receptor 2	33	1	0	34
Xanthine dehydrogenase/oxidase	0	1	0	1
TAR DNA-binding protein 43	17	1	0	18
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	2	2	4
ATPase family AAA domain-containing protein 5	31	0	0	31
Ataxin-2	41	0	0	41
glp-1 receptor, partial	17	0	0	17
hypoxia-inducible factor 1 alpha subunit	23	0	0	23
ATAD5 protein, partial	25	0	0	25
Fumarate hydratase	25	0	0	25
caspase 7, apoptosis-related cysteine protease	13	0	0	13
progesterone receptor	38	0	0	38
farnesoid X nuclear receptor	37	0	0	37
polyprotein	25	0	0	25
67.9K protein	33	0	0	33
peroxisome proliferator activated receptor gamma	43	0	0	43
vitamin D (1,25- dihydroxyvitamin D3) receptor	41	0	0	41
caspase-3	13	0	0	13
IDH1	20	0	0	20
aryl hydrocarbon receptor	22	0	0	22
v-jun sarcoma virus 17 oncogene homolog (avian)	30	0	0	30
nuclear receptor subfamily 1, group I, member 2	12	0	0	12
cellular tumor antigen p53 isoform a	16	0	0	16
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	20	0	0	20
chromobox protein homolog 1	37	0	0	37
transcriptional regulator ERG isoform 3	6	0	0	6
thyroid hormone receptor beta isoform 2	60	0	0	60
histone deacetylase 9 isoform 3	8	0	0	8
mitogen-activated protein kinase 1	19	0	0	19
urokinase-type plasminogen activator precursor	13	0	0	13
plasminogen precursor	13	0	0	13
urokinase plasminogen activator surface receptor precursor	13	0	0	13
Vif	0	1	0	2
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	2	1	0	3
neuropeptide S receptor isoform A	12	0	0	12
Interferon beta	52	0	0	52
Cellular tumor antigen p53	57	0	0	57
Integrin beta-3	14	1	0	15
Integrin alpha-IIb	14	0	0	14
Methionine aminopeptidase	0	1	0	1
Inositol monophosphatase 1	14	0	0	14
Chain A, Cruzipain	12	0	0	12
interleukin 8	11	0	0	11
peroxisome proliferator-activated receptor delta	37	0	0	37
tumor necrosis factor	2	0	0	2
vitamin D3 receptor isoform VDRA	33	0	0	33
Nuclear receptor ROR-gamma	12	0	0	12
Potassium voltage-gated channel subfamily H member 2	0	37	0	37
Aurora kinase B	0	1	7	8
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
NFKB1 protein, partial	14	0	0	14
alpha-galactosidase	11	0	0	11
cytochrome P450 2C19 precursor	16	0	0	16
flap endonuclease 1	16	0	0	16
DNA polymerase iota isoform a (long)	30	0	0	30
muscarinic acetylcholine receptor M1	23	0	0	23
lethal factor (plasmid)	14	0	0	14
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
ATP-dependent phosphofructokinase	29	0	0	29
Chain A, JmjC domain-containing histone demethylation protein 3A	9	0	0	9
5-hydroxytryptamine receptor 3E	0	5	0	5
acetylcholinesterase	29	0	0	29
SMAD family member 2	19	0	0	19
USP1 protein, partial	34	0	0	34
PPM1D protein	21	0	0	21
SMAD family member 3	19	0	0	19
Microtubule-associated protein tau	34	0	0	34
estrogen receptor 2 (ER beta)	31	0	0	31
G	35	0	0	35
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	8	0	0	8
thyroid stimulating hormone receptor	20	0	0	20
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	16	0	0	16
lysosomal alpha-glucosidase preproprotein	8	0	0	8
mu-type opioid receptor isoform MOR-1	0	0	1	1
potassium voltage-gated channel subfamily H member 2 isoform d	26	0	0	26
nuclear receptor ROR-gamma isoform 1	34	0	0	34
histone acetyltransferase KAT2A isoform 1	20	0	0	20
5-hydroxytryptamine receptor 2A	0	0	1	1
Solute carrier family 22 member 2	0	9	0	10
5-hydroxytryptamine receptor 3A	0	2	0	2
5-hydroxytryptamine receptor 3B	0	5	0	5
HLA class I histocompatibility antigen, B alpha chain	35	0	0	35
5-hydroxytryptamine receptor 1A	0	15	8	23
Neuronal acetylcholine receptor subunit alpha-4	3	2	0	5
Neuronal acetylcholine receptor subunit beta-2	3	2	0	5
D(2) dopamine receptor	0	21	2	30
Alpha-1B adrenergic receptor	0	26	4	30
Alpha-2C adrenergic receptor	0	19	1	20
D	0	15	0	15
5-hydroxytryptamine receptor 1A	0	22	0	23
Muscarinic acetylcholine receptor M3	0	14	1	15
D(1A) dopamine receptor	0	14	0	17
D(4) dopamine receptor	0	14	1	20
D(1B) dopamine receptor	0	5	0	8
Alpha-1D adrenergic receptor	0	24	4	28
Alpha-1D adrenergic receptor	0	19	0	19
5-hydroxytryptamine receptor 2A	0	25	2	32
5-hydroxytryptamine receptor 2C	0	26	1	28
D(4) dopamine receptor	0	9	0	9
Histamine H1 receptor	0	7	2	9
Sodium-dependent serotonin transporter	0	21	2	23
5-hydroxytryptamine receptor 7	0	11	0	11
5-hydroxytryptamine receptor 7	0	13	0	13
Alpha-1A adrenergic receptor	0	11	0	11
Histamine H1 receptor	0	22	3	28
Alpha-1B adrenergic receptor	0	7	0	7
D(3) dopamine receptor	0	15	2	22
5-hydroxytryptamine receptor 2B	0	24	1	26
Alpha-1A adrenergic receptor	0	27	4	31
5-hydroxytryptamine receptor 3A	0	6	0	6
5-hydroxytryptamine receptor 6	0	15	0	17
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	5	0	5
5-hydroxytryptamine receptor 3D	0	5	0	5
Multidrug and toxin extrusion protein 2	0	9	0	9
5-hydroxytryptamine receptor 3C	0	5	0	5
Inositol hexakisphosphate kinase 1	35	0	0	35
Multidrug and toxin extrusion protein 1	0	9	0	9
Histamine H3 receptor	0	4	0	4
cytochrome P450 2C9, partial	35	0	0	35
aldehyde dehydrogenase 1 family, member A1	45	0	0	45
Metabotropic glutamate receptor 6	0	0	1	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	2	0	3
Glutamate receptor ionotropic, NMDA 1	0	6	0	8
Excitatory amino acid transporter 1	0	1	0	1
Excitatory amino acid transporter 2	0	1	0	1
Excitatory amino acid transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	6	0	8
Glutamate receptor ionotropic, NMDA 2C	0	6	0	8
Metabotropic glutamate receptor 1	0	0	1	1
Metabotropic glutamate receptor 2	0	0	1	1
Carbonic anhydrase-like protein, putative	0	0	0	3
Glutamate receptor ionotropic, NMDA 2D	0	6	0	8
Glutamate receptor ionotropic, NMDA 3B	0	6	0	8
Glutamate receptor ionotropic, NMDA 3A	0	6	0	8
thioredoxin glutathione reductase	9	0	0	9
P53	2	0	0	2
peripheral myelin protein 22 isoform 1	20	0	0	20
cytochrome P450 3A4 isoform 1	36	0	0	36
M-phase phosphoprotein 8	15	0	0	15
Protein-arginine deiminase type-4	0	3	0	3
Chain A, Putative fructose-1,6-bisphosphate aldolase	14	0	0	14
Chain A, 2-oxoglutarate Oxygenase	17	0	0	17
dopamine D1 receptor	5	0	0	5
15-lipoxygenase, partial	15	0	0	15
Thrombopoietin	10	0	0	10
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	20	0	0	20
regulator of G-protein signaling 4	17	0	0	17
Lysine-specific demethylase 4E	0	3	0	3
Parkin	6	0	0	6
cytochrome P450 2D6 isoform 1	14	0	0	14
galactokinase	1	0	0	1
hexokinase-4 isoform 1	2	0	0	2
cytochrome P450 2C9 precursor	17	0	0	17
glucokinase regulatory protein	2	0	0	2
atrial natriuretic peptide receptor 2 precursor	5	0	0	5
ras-related protein Rab-9A	10	0	0	10
serine/threonine-protein kinase mTOR isoform 1	14	0	0	14
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	14	0	0	14
DNA polymerase eta isoform 1	9	0	0	9
Cocaine esterase	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	15	0	0	15
Tyrosyl-DNA phosphodiesterase 2	0	2	0	2
Amyloid-beta precursor protein	4	5	0	9
60 kDa chaperonin	0	3	0	3
60 kDa heat shock protein, mitochondrial	0	4	0	4
Indoleamine 2,3-dioxygenase 1	0	2	0	2
NAD	0	1	0	1
NADPH--cytochrome P450 reductase	0	1	0	1
Protein kinase C alpha type	0	4	7	11
Nuclear factor NF-kappa-B p105 subunit	0	2	0	2
Protein-glutamine gamma-glutamyltransferase 2	0	2	0	2
Liver carboxylesterase 1	0	1	0	5
Caspase-1	0	3	0	3
M-phase inducer phosphatase 1	0	2	0	2
Alpha-synuclein	9	1	0	10
Histamine H2 receptor	26	2	0	31
Tyrosine-protein kinase JAK3	0	8	4	15
10 kDa heat shock protein, mitochondrial	0	4	0	4
Nuclear factor NF-kappa-B p100 subunit	0	2	0	2
Transcription factor p65	0	2	0	2
Receptor-type tyrosine-protein phosphatase eta	0	2	0	2
Thiosulfate sulfurtransferase	0	4	0	4
Receptor protein-tyrosine kinase	0	2	0	2
60 kDa chaperonin	0	4	0	4
10 kDa chaperonin	0	4	0	4
Single-stranded DNA cytosine deaminase	3	0	0	3
Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0	1	0	1
phosphoglycerate kinase	4	0	0	4
Chain A, Betaine ABC transporter permease and substrate binding protein	0	0	1	1
Chain A, Osmoprotection protein (ProX)	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	2	2
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	2	2
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	2	2
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	2	2
Proton-coupled amino acid transporter 1	0	4	0	5
Chain A, Avidin	0	0	1	1
Chain A, Protein (streptavidin)	0	0	1	1
Chain B, Protein (streptavidin)	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin Complex With Biotin	0	0	1	1
Chain D, Circularly Permuted Core-streptavidin E51/a46	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
apical membrane antigen 1, AMA1	5	0	0	5
nonstructural protein 1	0	2	0	2
green fluorescent protein, partial	0	1	0	1
insulin-degrading enzyme isoform 1	0	0	1	1
Streptavidin	0	0	1	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	2
Chain H, Proteasome component PUP1	0	1	0	1
Chain I, Proteasome component PUP3	0	1	0	1
Chain K, Proteasome component PRE2	0	1	0	1
Chain L, Proteasome component C5	0	1	0	1
Chain K, Proteasome component PRE2	0	1	0	1
Chain L, Proteasome component C5	0	1	0	1
Proteasome subunit beta type-11	0	1	0	2
Caspase-7	7	0	0	7
caspase-3	7	0	0	7
26S proteasome non-ATPase regulatory subunit 11	0	1	0	1
26S proteasome non-ATPase regulatory subunit 12	0	1	0	1
26S proteasome non-ATPase regulatory subunit 14	0	1	0	1
Proteasome subunit alpha type-7	0	1	0	2
Histone deacetylase 3	0	4	0	4
26S proteasome non-ATPase regulatory subunit 3	0	1	0	1
Prothrombin	0	1	0	3
Chymotrypsinogen A	0	1	0	2
Cathepsin B	0	1	0	1
Neutrophil elastase	0	1	0	1
Cathepsin G	0	2	0	2
Lysosomal protective protein	0	1	0	1
Chymotrypsinogen B	0	1	0	1
26S proteasome regulatory subunit 6A	0	1	0	1
Proteasome subunit beta type-1	0	1	0	3
Chymase	0	1	0	1
Proteasome subunit alpha type-1	0	1	0	2
Proteasome subunit alpha type-2	0	1	0	2
Proteasome subunit alpha type-3	0	1	0	2
Proteasome subunit alpha type-4	0	1	0	2
Proteasome subunit beta type-8	0	1	0	2
Proteasome subunit beta type-8	0	1	0	1
Proteasome subunit beta type-9	0	1	0	2
Proteasome subunit alpha type-5	0	1	0	2
Proteasome subunit beta type-4	0	1	0	2
Proteasome subunit beta type-6	0	1	0	2
Proteasome subunit beta type-5	0	2	0	4
26S proteasome regulatory subunit 7	0	1	0	1
Lon protease homolog, mitochondrial	0	1	0	1
Proteasome subunit beta type-10	0	1	0	2
26S proteasome regulatory subunit 6B	0	1	7	8
26S proteasome non-ATPase regulatory subunit 8	0	1	0	1
Proteasome subunit beta type-3	0	1	0	2
Proteasome subunit beta type-2	0	1	0	3
26S proteasome non-ATPase regulatory subunit 7	0	1	0	1
26S proteasome non-ATPase regulatory subunit 4	0	1	0	1
26S proteasome complex subunit SEM1	0	1	0	1
Proteasome subunit alpha type-6	0	1	1	3
26S proteasome regulatory subunit 4	0	1	0	1
26S proteasome regulatory subunit 8	0	1	0	1
26S proteasome regulatory subunit 10B	0	1	0	1
26S proteasome non-ATPase regulatory subunit 2	0	1	0	1
Histone deacetylase 1	0	4	0	4
26S proteasome non-ATPase regulatory subunit 6	0	1	0	1
Proteasomal ubiquitin receptor ADRM1	0	1	0	1
ATP-dependent Clp protease proteolytic subunit	0	1	1	2
NACHT, LRR and PYD domains-containing protein 3	0	2	0	2
Proteasome subunit alpha-type 8	0	1	0	2
Histone deacetylase 2	0	4	0	4
Proteasome subunit beta type-7	0	1	0	2
26S proteasome non-ATPase regulatory subunit 1	0	1	0	1
Histone deacetylase 8	0	3	0	3
Histone deacetylase 6	0	4	0	4
26S proteasome non-ATPase regulatory subunit 13	0	1	0	1
Kappa-type opioid receptor	0	5	0	5
DNA topoisomerase	0	1	0	1
glucocerebrosidase	11	0	0	11
putative alpha-glucosidase	1	0	0	1
huntingtin isoform 2	13	0	0	13
eukaryotic translation initiation factor 2-alpha kinase 3 isoform 1 precursor	0	0	1	1
relaxin receptor 1 isoform 1	2	0	0	2
Telomerase reverse transcriptase	0	1	0	1
Serine/threonine-protein kinase Chk1	0	1	8	9
Type-2 restriction enzyme ScaI	0	1	0	1
Deoxyribonuclease-2-alpha	0	1	0	1
Deoxyribonuclease-1	0	1	0	1
Type-2 restriction enzyme PstI	0	1	0	1
Type-2 restriction enzyme EcoRI	0	1	0	1
DNA ligase	0	1	0	1
Heterogeneous nuclear ribonucleoprotein A1	0	0	1	1
DNA topoisomerase 1	0	3	3	13
DNA topoisomerase 2-alpha	0	4	7	17
Type-2 restriction enzyme BamHI	0	1	0	1
Somatostatin receptor type 1	0	1	0	1
Somatostatin receptor type 2	0	1	0	1
Somatostatin receptor type 4	0	1	0	1
Somatostatin receptor type 3	0	1	0	1
Somatostatin receptor type 5	0	1	0	1
Type-2 restriction enzyme HindIII	0	1	0	1
Histone deacetylase 4	0	2	0	2
Ribonuclease pancreatic	0	1	0	1
DNA topoisomerase 2-beta	0	2	8	18
DNA topoisomerase 1	0	2	0	3
DNA topoisomerase 1	0	1	0	1
Integrase	0	4	0	4
Histone deacetylase 7	0	2	0	2
DNA topoisomerase type IB small subunit	0	0	1	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	2	0	2
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	2	0	2
Vpr	5	0	0	5
Albumin	0	0	5	5
Major prion protein	0	0	4	4
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	3	0	7
Sodium channel protein type 4 subunit alpha	0	5	0	7
Sodium channel protein type 9 subunit alpha	0	6	0	6
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	2	0	2
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
B2 metallo-beta-lactamase	0	0	0	2
Class D beta-lactamase	0	0	0	1
Metallo-b-lactamase	0	0	0	2
Beta-lactamase class B VIM-2	0	0	0	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	8	0	0	8
DNA polymerase kappa isoform 1	17	0	0	17
Chain A, serum paraoxonase	0	1	0	1
Neutrophil cytosol factor 1	0	1	0	1
Poly [ADP-ribose] polymerase tankyrase-2	0	1	0	1
Spike glycoprotein	0	2	6	8
Replicase polyprotein 1ab	0	2	7	9
Transmembrane protease serine 2	0	2	6	8
Procathepsin L	0	2	6	8
Replicase polyprotein 1a	0	2	6	8
Replicase polyprotein 1ab	0	2	6	8
Mitogen-activated protein kinase 3	0	1	7	8
Acid ceramidase	0	1	0	1
Acid ceramidase	0	1	0	1
Angiotensin-converting enzyme 2	0	2	6	8
Sulfide:quinone oxidoreductase, mitochondrial	0	1	0	1
endonuclease IV	13	0	0	13
Glutathione reductase, mitochondrial	0	1	0	1
Glutathione reductase	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
WRN	3	0	0	3
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Metallo-beta-lactamase VIM-11	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
DNA (cytosine-5)-methyltransferase 1 isoform b	0	1	0	1
serine/threonine-protein kinase PLK1	6	0	0	6
carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1	0	1	0	1
Solute carrier family 22 member 8	0	1	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase OXA-1	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 1	0	1	0	1
Beta-lactamase TEM	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Metallo-beta-lactamase VIM-13	0	0	0	1
Beta-lactamase	0	0	0	1
Efflux transporter	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase Toho-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 7	0	1	0	3
Metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Histamine H3 receptor	0	0	0	1
Solute carrier family 22 member 11	0	1	0	3
Solute carrier family 22 member 8	0	1	0	1
Beta-lactamase VIM-1	0	0	0	1
Solute carrier family 22 member 7	0	1	0	2
Alpha-2A adrenergic receptor	0	16	1	17
Vitamin D3 receptor	0	2	2	4
Alpha-2B adrenergic receptor	0	17	1	18
Retinoic acid receptor RXR-alpha	0	1	1	2
Guanine nucleotide-binding protein G	4	0	0	4
Ileal sodium/bile acid cotransporter	0	2	0	2
Bile acid receptor	0	0	1	1
G-protein coupled bile acid receptor 1	0	0	2	2
Bile acid receptor	0	1	2	3
bromodomain adjacent to zinc finger domain 2B	10	0	0	10
FAD-linked sulfhydryl oxidase ALR	0	0	0	3
Solute carrier organic anion transporter family member 1B3	0	14	0	16
NADPH oxidase 1	0	1	0	1
Snq2p	0	0	0	2
Adenylate cyclase type 1	0	4	0	4
D(1A) dopamine receptor	10	0	0	10
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Transient receptor potential cation channel subfamily V member 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	11	0	11
5-hydroxytryptamine receptor 4	0	16	0	16
Potassium channel subfamily K member 2	0	2	1	3
Epidermal growth factor receptor	0	7	8	15
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	5	3	8
Major prion protein	0	0	1	1
Tyrosine-protein kinase Fyn	0	4	7	11
Aldo-keto reductase family 1 member B1	0	14	0	14
Muscarinic acetylcholine receptor M2	0	14	1	15
Muscarinic acetylcholine receptor M4	0	16	1	17
Muscarinic acetylcholine receptor M1	0	6	0	6
Muscarinic acetylcholine receptor M3	0	5	0	5
Muscarinic acetylcholine receptor M4	0	5	0	5
Muscarinic acetylcholine receptor M5	0	7	0	7
Muscarinic acetylcholine receptor M5	0	13	0	13
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	3	1	4
Muscarinic acetylcholine receptor M2	0	5	0	5
Muscarinic acetylcholine receptor M1	0	14	2	16
Polyunsaturated fatty acid lipoxygenase ALOX15	0	5	0	5
Angiotensin-converting enzyme	0	12	0	12
Sphingomyelin phosphodiesterase	0	2	0	2
D(3) dopamine receptor	0	10	0	10
Alpha-2B adrenergic receptor	0	13	2	15
D(2) dopamine receptor	0	5	0	5
Substance-K receptor	0	8	0	8
Adenylate cyclase type 3	0	4	0	4
Alpha-2C adrenergic receptor	0	13	2	15
UDP-glucuronosyltransferase 1A4	0	2	0	8
Alpha-2A adrenergic receptor	0	13	2	15
Sodium-dependent noradrenaline transporter	0	20	0	20
Sodium-dependent dopamine transporter	0	12	0	12
Histamine H2 receptor	0	10	0	10
D(1B) dopamine receptor	0	7	0	7
Adenylate cyclase type 2	0	4	0	4
Adenylate cyclase type 4	0	4	0	4
5-hydroxytryptamine receptor 1B	0	12	0	12
Trypanothione reductase	0	2	0	2
Melanocortin receptor 4	0	2	0	2
Melanocortin receptor 5	0	4	0	4
Pleiotropic ABC efflux transporter of multiple drugs	0	2	0	4
Mu-type opioid receptor	0	6	1	7
Sodium channel protein type 1 subunit alpha	0	4	0	4
Adenylate cyclase type 8	0	4	0	4
Delta-type opioid receptor	0	4	0	4
Melanocortin receptor 3	0	2	0	2
5-hydroxytryptamine receptor 7	0	5	0	5
Gastrin/cholecystokinin type B receptor	0	3	0	3
Calmodulin	0	1	2	3
Aldehyde oxidase 1	0	1	0	1
Sodium channel protein type 7 subunit alpha	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1D	0	11	0	11
Sodium-dependent dopamine transporter	0	9	0	9
Adenylate cyclase type 6	0	4	0	4
Adenylate cyclase type 5	0	4	0	4
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Aldehyde oxidase	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	11	0	11
Voltage-dependent L-type calcium channel subunit alpha-1C	0	12	0	12
Sodium channel protein type 5 subunit alpha	0	9	0	9
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	11	0	11
Adenylyl cyclase 7	0	4	0	4
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
D	0	4	0	4
Sodium channel protein type 2 subunit alpha	0	4	0	4
Sigma non-opioid intracellular receptor 1	0	11	0	11
Sodium channel protein type 3 subunit alpha	0	4	0	4
Sodium channel protein type 11 subunit alpha	0	3	0	3
Sodium channel protein type 8 subunit alpha	0	3	0	3
Sodium channel protein type 10 subunit alpha	0	3	0	3
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	2	0	3
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Acetylcholinesterase	0	7	0	7
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	1	0	2
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Solute carrier family 22 member 1	0	3	0	4
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
Solute carrier family 22 member 2	0	2	0	3
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Thymidine kinase	0	0	0	2
NPC intracellular cholesterol transporter 1 precursor	8	0	0	8
Sodium-dependent noradrenaline transporter	0	2	0	2
Tryptophan 5-hydroxylase 1	0	2	0	2
Aldo-keto reductase family 1 member B1	0	2	0	2
Aromatase	0	1	0	1
Sodium-dependent serotonin transporter	0	2	0	2
Sodium-dependent dopamine transporter	0	4	0	4
Sigma non-opioid intracellular receptor 1	0	5	0	5
Transporter	0	13	0	13
Chain A, BCL-2-RELATED PROTEIN A1	0	0	2	2
tyrosine-protein kinase Yes	8	0	0	8
bcl-2-like protein 11 isoform 1	0	0	2	2
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	2	0	2
Deoxycytidine kinase	0	0	7	11
Adenosine receptor A3	0	2	0	2
Rap guanine nucleotide exchange factor 4	7	0	0	7
Beta-1 adrenergic receptor	0	1	0	1
DNA polymerase beta	9	0	0	9
short transient receptor potential channel 6 isoform 1	0	0	1	1
transient receptor potential cation channel subfamily V member 1	2	0	0	2
Beta-2 adrenergic receptor	0	4	0	4
Beta-1 adrenergic receptor	0	3	0	3
Endothelin receptor type B	3	3	0	6
5-hydroxytryptamine receptor 3A	0	4	0	4
Endothelin receptor type B	0	3	0	3
Beta-3 adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1D	0	7	0	7
5-hydroxytryptamine receptor 1F	0	7	0	7
Histamine H1 receptor	0	6	0	6
5-hydroxytryptamine receptor 2C	0	5	0	5
5-hydroxytryptamine receptor 2A	0	4	0	4
5-hydroxytryptamine receptor 3A	0	6	0	6
5-hydroxytryptamine receptor 5A	0	2	0	2
D(2) dopamine receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
D(2) dopamine receptor	0	3	0	3
5-hydroxytryptamine receptor 2B	0	4	0	4
5-hydroxytryptamine receptor 4	0	2	0	2
Transporter	0	5	0	5
Cholecystokinin receptor type A	0	2	0	2
5-hydroxytryptamine receptor 1A	0	2	0	2
Histamine H4 receptor	0	2	1	3
5-hydroxytryptamine receptor 3B	0	6	0	6
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	5	0	5
Gamma-aminobutyric acid receptor subunit delta	0	5	0	5
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	5	1	6
Gamma-aminobutyric acid receptor subunit beta-1	0	5	0	5
Gamma-aminobutyric acid receptor subunit gamma-2	0	5	1	6
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	5	1	6
5-hydroxytryptamine receptor 6	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-5	0	5	1	6
Gamma-aminobutyric acid receptor subunit alpha-3	0	5	1	6
5-hydroxytryptamine receptor 5A	0	3	0	3
5-hydroxytryptamine receptor 5B	0	3	0	3
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	5	0	5
Gamma-aminobutyric acid receptor subunit beta-2	0	5	0	5
Gamma-aminobutyric acid receptor subunit alpha-4	0	5	0	5
Gamma-aminobutyric acid receptor subunit epsilon	0	5	0	5
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	3	0	3
Leukotriene B4 receptor 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	5	0	5
5-hydroxytryptamine receptor 4	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-1	0	5	0	5
Gamma-aminobutyric acid receptor subunit gamma-3	0	5	0	5
Leukotriene B4 receptor 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	5	0	5
B2 bradykinin receptor	0	1	0	1
Dihydrofolate reductase	0	6	0	8
Dihydrofolate reductase	0	2	0	2
Beta-lactamase	0	2	0	2
Beta-galactosidase	0	1	0	2
Choline O-acetyltransferase	0	1	0	1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	0	2	0	2
PH domain leucine-rich repeat-containing protein phosphatase 2	0	1	0	1
Chymotrypsin-C	0	1	0	1
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
LMP1 [Human herpesvirus 4]	0	0	0	3
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	3	0	3
transactivating tegument protein VP16 [Human herpesvirus 1]	0	3	0	3
nuclear receptor coactivator 3 isoform a	0	3	0	3
Thymidine kinase 2, mitochondrial	0	1	0	1
Thymidine kinase	0	1	0	1
Thymidylate synthase	0	4	0	5
Thymidine kinase	0	1	0	1
Probable deoxycytidylate deaminase	0	0	0	2
Cytidine deaminase	0	1	0	4
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Deoxynucleoside kinase	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Matrix metalloproteinase-9	0	1	0	1
Isocitrate lyase	0	1	0	1
RAD51	0	1	0	1
caspase-1 isoform alpha precursor	5	0	0	5
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1	0	1	0	1
Caspase-7	5	0	0	5
Growth factor receptor-bound protein 2	0	1	0	1
Pantothenate synthetase	0	1	0	1
Discoidin domain-containing receptor 2	0	1	7	8
Growth factor receptor-bound protein 2	0	1	0	1
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase	0	0	1	1
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase	0	1	0	1
Myeloperoxidase	0	2	0	2
Dihydrofolate reductase	0	5	0	5
Chain A, Pol Polyprotein	0	1	0	1
Chain A, Pol Polyprotein	0	1	0	1
Chain B, Pol Polyprotein	0	1	0	1
Chain A, Pol Polyprotein	0	1	0	1
Chain B, Pol Polyprotein	0	1	0	1
Chain A, HIV-1 Protease	0	1	0	1
Chain B, HIV-1 Protease	0	1	0	1
Chain A, protease	0	1	0	1
Chain B, protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease (Retropepsin)	0	0	1	1
Chain B, Protease (Retropepsin)	0	0	1	1
Chain A, Protease (Retropepsin)	0	0	1	1
Chain B, Protease (Retropepsin)	0	0	1	1
Chain A, HIV-1 Protease	0	1	0	1
Chain B, HIV-1 Protease	0	1	0	1
Chain A, HIV-1 Protease	0	1	0	1
Chain B, HIV-1 Protease	0	1	0	1
Chain A, HIV-1 Protease	0	1	0	1
Chain B, HIV-1 Protease	0	1	0	1
Chain A, HIV-1 Protease	0	1	0	1
Chain B, HIV-1 Protease	0	1	0	1
Chain A, HIV-1 Protease	0	1	0	1
Chain B, HIV-1 Protease	0	1	0	1
Chain A, HIV-1 Protease	0	1	0	1
Chain B, HIV-1 Protease	0	1	0	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, HIV-1 protease	0	0	1	1
Chain B, HIV-1 protease	0	0	1	1
Chain A, HIV-1 protease	0	0	1	1
Chain B, HIV-1 protease	0	0	1	1
Chain A, HIV-1 Protease	0	0	1	1
Chain B, HIV-1 Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, HIV-1 protease	0	1	0	1
Chain B, HIV-1 protease	0	1	0	1
Chain A, HIV-1 protease	0	1	0	1
Chain B, HIV-1 protease	0	1	0	1
Chain A, HIV-1 protease	0	1	0	1
Chain B, HIV-1 protease	0	1	0	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Pol polyprotein	0	1	0	1
Chain B, Pol polyprotein	0	1	0	1
Gag-Pol polyprotein	0	5	0	5
Gag-Pol polyprotein	0	6	1	7
Potassium voltage-gated channel subfamily E member 1	0	4	0	4
Potassium voltage-gated channel subfamily KQT member 1	0	5	0	5
Protease	0	10	4	21
Gag-Pol polyprotein	0	1	0	1
Potassium voltage-gated channel subfamily D member 3	0	3	0	3
Protease	0	8	6	15
Chain A, STEROID DELTA-ISOMERASE	0	0	1	1
Steroid Delta-isomerase	0	0	1	1
Thymidine kinase 2	0	2	0	2
AAA family ATPase	0	0	0	2
nonstructural protein 1	15	0	0	15
eyes absent homolog 2 isoform a	2	0	0	2
Prostaglandin G/H synthase 1	0	5	0	5
Prostaglandin G/H synthase 2	0	6	2	8
Aldo-keto reductase family 1 member C3	0	6	0	6
Prostaglandin G/H synthase 2	0	2	0	2
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	7	0	0	7
Kelch-like ECH-associated protein 1	0	0	1	1
Nuclear factor erythroid 2-related factor 2	0	0	1	1
Cereblon isoform 4	0	6	0	6
Insulin-like growth factor-binding protein 5	0	0	1	1
Protein cereblon	0	8	3	16
Chain A, POL POLYPROTEIN	0	1	0	1
Chain A, POL POLYPROTEIN	0	1	0	1
Chain B, POL POLYPROTEIN	0	1	0	1
Chain A, POL POLYPROTEIN	0	1	0	1
Chain B, POL POLYPROTEIN	0	1	0	1
Chain A, Pol Polyprotein	0	1	0	1
Chain B, Pol Polyprotein	0	1	0	1
Prothrombin	0	1	0	1
Gag-Pol polyprotein	0	4	0	4
Acetylcholinesterase	0	0	0	1
Cannabinoid receptor 1	0	1	0	1
Microsomal triglyceride transfer protein large subunit	0	1	0	1
Envelope glycoprotein gp160 [Cleaved into: Surface protein gp120	0	1	0	1
Fructose-1,6-bisphosphatase 1	0	0	0	1
Reverse transcriptase	0	2	2	4
Cholesterol 24-hydroxylase	0	2	2	4
Env polyprotein	0	0	2	2
Regulatory protein E2	0	0	2	2
ATP-dependent translocase ABCB1	0	3	0	3
DNA topoisomerase 2	0	0	0	2
ATP-dependent translocase ABCB1	0	4	0	4
UDP-glucuronosyltransferase 1A1	0	3	0	5
Caspase-3	0	1	0	1
DNA topoisomerase 2-alpha	0	0	0	1
Tubulin beta-2B chain	0	2	1	5
Similar to alpha-tubulin isoform 1	0	2	1	5
Similar to alpha-tubulin isoform 1	0	2	0	4
Chain A, Reverse transcriptase/ribonuclease H	0	1	0	1
Chain B, p51 RT	0	1	0	1
Chain A, Reverse transcriptase/ribonuclease H	0	1	0	1
Chain B, p51 RT	0	1	0	1
Cruzipain	0	1	0	1
Multidrug resistance-associated protein 1	0	2	0	3
Bone morphogenetic protein receptor type-1B	0	0	7	7
Cell division cycle 7-related protein kinase	0	0	5	5
Serine/threonine-protein kinase PLK4	0	1	7	8
ATP-dependent RNA helicase DDX3X	0	0	7	7
Pyridoxal kinase	0	0	7	7
Citron Rho-interacting kinase	0	0	7	7
Aurora kinase A	0	0	7	7
Cyclin-G-associated kinase	0	1	7	8
Ephrin type-B receptor 6	0	0	7	7
Peroxisomal acyl-coenzyme A oxidase 3	0	0	7	7
Receptor-interacting serine/threonine-protein kinase 2	0	0	7	7
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	7	7
Dynamin-like 120 kDa protein, mitochondrial	0	0	7	7
Eukaryotic translation initiation factor 5B	0	0	4	4
Rho-associated protein kinase 2	0	2	8	10
Serine/threonine-protein kinase ULK1	0	0	7	7
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	7	7
Ribosomal protein S6 kinase alpha-5	0	2	7	9
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	7	7
Ribosomal protein S6 kinase alpha-4	0	0	7	7
Serine/threonine-protein kinase 16	0	0	7	7
Serine/threonine-protein kinase 10	0	0	7	7
Serine/threonine-protein kinase D3	0	1	7	8
Structural maintenance of chromosomes protein 2	0	0	6	6
Mitogen-activated protein kinase kinase kinase 6	0	0	7	7
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	7	7
Serine/threonine-protein kinase LATS1	0	0	7	7
Serine/threonine-protein kinase PAK 4	0	0	7	7
Tyrosine-protein kinase ABL1	0	3	9	14
High affinity nerve growth factor receptor	0	0	7	7
Guanine nucleotide-binding protein G(i) subunit alpha-2	0	0	4	4
ADP/ATP translocase 2	0	0	7	7
Protein kinase C beta type	0	2	7	9
Insulin receptor	0	1	7	8
Tyrosine-protein kinase Lck	0	2	7	9
Glycogen phosphorylase, liver form	0	0	7	7
Tyrosine-protein kinase Fes/Fps	0	0	7	7
Adenine phosphoribosyltransferase	0	0	4	4
Tyrosine-protein kinase Yes	0	1	7	8
Tyrosine-protein kinase Lyn	0	1	7	8
Proto-oncogene tyrosine-protein kinase receptor Ret	0	1	7	8
Insulin-like growth factor 1 receptor	0	0	7	7
Signal recognition particle receptor subunit alpha	0	0	6	6
Cytochrome c1, heme protein, mitochondrial	0	0	7	7
Hepatocyte growth factor receptor	0	0	7	7
Tyrosine-protein kinase HCK	0	1	7	8
Platelet-derived growth factor receptor beta	0	1	7	8
Tyrosine-protein kinase Fgr	0	1	5	6
Serine/threonine-protein kinase A-Raf	0	1	7	8
Glycogen phosphorylase, brain form	0	0	7	7
Breakpoint cluster region protein	0	0	8	10
Serine/threonine-protein kinase pim-1	0	0	7	7
Fibroblast growth factor receptor 1	0	1	7	8
Cyclin-dependent kinase 4	0	0	7	7
ADP/ATP translocase 3	0	0	7	7
Inosine-5'-monophosphate dehydrogenase 2	0	2	6	8
Proto-oncogene tyrosine-protein kinase Src	0	2	7	9
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	6	6
Serine/threonine-protein kinase B-raf	0	1	7	8
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	7	7
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	0	7	7
Tyrosine-protein kinase Fer	0	0	7	7
cAMP-dependent protein kinase catalytic subunit alpha	0	2	7	9
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	7	7
Casein kinase II subunit alpha'	0	2	7	9
Ras-related protein Rab-6A	0	0	5	5
Ephrin type-A receptor 1	0	0	7	7
Multifunctional protein ADE2	0	0	7	7
cAMP-dependent protein kinase catalytic subunit gamma	0	1	6	7
cAMP-dependent protein kinase catalytic subunit beta	0	1	7	8
Ferrochelatase, mitochondrial	0	0	7	7
Ribosomal protein S6 kinase beta-1	0	2	7	9
Tyrosine-protein kinase JAK1	0	7	9	18
Cyclin-dependent kinase 2	0	2	8	10
Beta-adrenergic receptor kinase 1	0	0	7	7
Probable ATP-dependent RNA helicase DDX6	0	0	7	7
MAP/microtubule affinity-regulating kinase 3	0	0	7	7
Mitogen-activated protein kinase 1	0	2	7	9
Ephrin type-A receptor 2	0	1	7	8
Ephrin type-B receptor 2	0	0	7	7
Non-receptor tyrosine-protein kinase TYK2	0	5	9	16
UMP-CMP kinase	0	0	3	3
Phosphatidylethanolamine-binding protein 1	0	0	6	6
Wee1-like protein kinase	0	0	7	7
Heme oxygenase 2	0	0	6	6
S-adenosylmethionine synthase isoform type-2	0	0	7	7
DnaJ homolog subfamily A member 1	0	0	7	7
RAC-alpha serine/threonine-protein kinase	0	4	7	11
RAC-beta serine/threonine-protein kinase	0	2	7	9
Dual specificity protein kinase TTK	0	0	5	5
DNA replication licensing factor MCM4	0	0	6	6
Myosin-10	0	0	5	5
Dual specificity mitogen-activated protein kinase kinase 2	0	1	7	8
Receptor-type tyrosine-protein kinase FLT3	0	2	7	9
Bone morphogenetic protein receptor type-1A	0	0	7	7
Activin receptor type-1B	0	0	7	7
TGF-beta receptor type-1	0	0	7	7
TGF-beta receptor type-2	0	0	7	7
Electron transfer flavoprotein subunit beta	0	0	4	4
Tyrosine-protein kinase CSK	0	2	7	9
Glycine--tRNA ligase	0	0	7	7
Protein kinase C iota type	0	1	7	8
Exosome RNA helicase MTR4	0	0	7	7
Serine/threonine-protein kinase mTOR	0	4	4	8
Tyrosine-protein kinase Tec	0	2	7	9
Tyrosine-protein kinase ABL2	0	1	7	8
Tyrosine-protein kinase FRK	0	1	7	8
G protein-coupled receptor kinase 6	0	1	5	6
Tyrosine-protein kinase SYK	0	1	7	8
Mitogen-activated protein kinase 8	0	1	7	8
Mitogen-activated protein kinase 9	0	0	7	7
Dual specificity mitogen-activated protein kinase kinase 3	0	0	7	7
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	6	6
Casein kinase I isoform alpha	0	1	6	7
Casein kinase I isoform delta	0	1	7	8
MAP kinase-activated protein kinase 2	0	1	7	8
Elongation factor Tu, mitochondrial	0	0	7	7
Choline-phosphate cytidylyltransferase A	0	0	4	4
Cysteine--tRNA ligase, cytoplasmic	0	0	6	6
Casein kinase I isoform epsilon	0	1	7	8
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	7	7
Dual specificity protein kinase CLK1	0	0	7	7
Dual specificity protein kinase CLK2	0	0	7	7
Dual specificity protein kinase CLK3	0	0	4	4
Glycogen synthase kinase-3 alpha	0	0	7	7
Glycogen synthase kinase-3 beta	0	2	7	9
Cyclin-dependent kinase 7	0	0	7	7
Cyclin-dependent kinase 9	0	0	7	7
Ras-related protein Rab-27A	0	0	6	6
Interleukin-1 receptor-associated kinase 1	0	0	7	7
Ribosomal protein S6 kinase alpha-3	0	1	7	8
Serine/threonine-protein kinase Nek2	0	0	7	7
Serine/threonine-protein kinase Nek3	0	0	7	7
Dual specificity mitogen-activated protein kinase kinase 6	0	0	7	7
Serine/threonine-protein kinase PLK1	0	1	6	7
LIM domain kinase 1	0	0	7	7
LIM domain kinase 2	0	0	7	7
Mitogen-activated protein kinase 10	0	0	7	7
Tyrosine--tRNA ligase, cytoplasmic	0	0	7	7
5'-AMP-activated protein kinase subunit gamma-1	0	0	7	8
Ephrin type-B receptor 3	0	0	7	7
Ephrin type-A receptor 5	0	0	7	7
Ephrin type-B receptor 4	0	0	7	7
Ephrin type-A receptor 4	0	0	7	7
Adenylate kinase 2, mitochondrial	0	0	7	8
Adenosine kinase	0	0	7	7
Ras-related protein Rab-10	0	0	7	7
Actin-related protein 3	0	0	7	7
Actin-related protein 2	0	0	6	6
GTP-binding nuclear protein Ran	0	0	7	7
Casein kinase I isoform gamma-2	0	1	7	8
Cyclin-dependent kinase 3	0	0	6	6
Cyclin-dependent kinase 6	0	0	7	7
Cyclin-dependent-like kinase 5	0	1	7	8
Cyclin-dependent kinase 16	0	0	7	7
Cyclin-dependent kinase 17	0	0	7	7
ATP-dependent 6-phosphofructokinase, platelet type	0	0	7	7
Dual specificity mitogen-activated protein kinase kinase 1	0	0	7	7
Protein kinase C theta type	0	1	7	8
Activin receptor type-1	0	0	7	7
Macrophage-stimulating protein receptor	0	0	7	7
Focal adhesion kinase 1	0	0	7	7
Protein kinase C delta type	0	1	7	8
Tyrosine-protein kinase BTK	0	4	8	12
Activated CDC42 kinase 1	0	0	7	7
Epithelial discoidin domain-containing receptor 1	0	0	7	7
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	7	7
Serine/threonine-protein kinase 4	0	0	7	7
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	7	8
Dual specificity mitogen-activated protein kinase kinase 5	0	0	7	7
Mitogen-activated protein kinase 7	0	0	7	7
Serine/threonine-protein kinase PAK 2	0	0	7	7
Serine/threonine-protein kinase 3	0	0	7	7
Mitogen-activated protein kinase kinase kinase 1	0	0	7	7
Integrin-linked protein kinase	0	0	7	7
Rho-associated protein kinase 1	0	0	7	7
Non-receptor tyrosine-protein kinase TNK1	0	0	7	7
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	7	7
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	7	7
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	7	7
Activin receptor type-2B	0	0	7	7
Bone morphogenetic protein receptor type-2	0	0	7	7
Protein-tyrosine kinase 6	0	1	7	8
cGMP-dependent protein kinase 1	0	1	7	8
Cyclin-dependent kinase 13	0	0	7	7
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	7	7
Protein-tyrosine kinase 2-beta	0	0	7	7
Maternal embryonic leucine zipper kinase	0	0	7	7
Structural maintenance of chromosomes protein 1A	0	0	6	6
Chromodomain-helicase-DNA-binding protein 4	0	0	7	7
Peroxisomal acyl-coenzyme A oxidase 1	0	0	4	4
Ephrin type-A receptor 7	0	0	6	6
Delta(24)-sterol reductase	0	0	6	6
Ribosomal protein S6 kinase alpha-1	0	1	7	8
Dual specificity testis-specific protein kinase 1	0	0	6	6
Myosin light chain kinase, smooth muscle	0	1	7	8
Mitogen-activated protein kinase 11	0	1	7	8
Serine/threonine-protein kinase STK11	0	0	7	7
Serine/threonine-protein kinase N1	0	0	7	7
Serine/threonine-protein kinase N2	0	0	7	7
Mitogen-activated protein kinase 14	0	2	7	9
Calcium/calmodulin-dependent protein kinase type IV	0	0	7	7
Mitogen-activated protein kinase kinase kinase 11	0	0	7	7
AP2-associated protein kinase 1	0	1	7	8
Myosin light chain kinase 3	0	1	7	8
Putative heat shock protein HSP 90-beta 2	0	0	7	7
Serine/threonine-protein kinase MRCK alpha	0	0	7	7
Serine/threonine-protein kinase MRCK gamma	0	0	7	7
Acyl-CoA dehydrogenase family member 10	0	0	7	7
Serine/threonine-protein kinase N3	0	0	5	5
Serine/threonine-protein kinase ULK3	0	0	7	7
Uncharacterized protein FLJ45252	0	0	7	7
Acyl-CoA dehydrogenase family member 11	0	0	6	6
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	7	7
Serine/threonine-protein kinase MARK2	0	0	7	7
ATP-dependent RNA helicase DHX30	0	0	6	6
Serine/threonine-protein kinase TAO1	0	0	7	7
STE20-related kinase adapter protein alpha	0	0	7	7
Myosin-14	0	0	6	6
AarF domain-containing protein kinase 1	0	0	7	7
ATP-dependent RNA helicase DDX42	0	0	4	4
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	7	7
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	0	0	2	2
Regulatory-associated protein of mTOR	0	2	0	2
Atypical kinase COQ8A, mitochondrial	0	0	7	7
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	7	7
Mitogen-activated protein kinase 15	0	0	7	7
Serine/threonine-protein kinase Nek9	0	0	7	7
Serine/threonine-protein kinase Nek7	0	0	5	5
ATP-dependent RNA helicase DDX1	0	0	7	7
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	7	7
MAP/microtubule affinity-regulating kinase 4	0	0	7	7
Serine/threonine-protein kinase Nek1	0	0	7	7
PAS domain-containing serine/threonine-protein kinase	0	0	7	7
Calcium/calmodulin-dependent protein kinase kinase 2	0	1	7	8
EKC/KEOPS complex subunit TP53RK	0	0	7	7
Dual specificity testis-specific protein kinase 2	0	0	4	4
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	7	7
Mitogen-activated protein kinase kinase kinase 5	0	0	7	7
Mitogen-activated protein kinase kinase kinase 3	0	0	7	7
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	7	7
Target of rapamycin complex subunit LST8	0	2	0	2
Nucleolar GTP-binding protein 1	0	0	7	7
Serine/threonine-protein kinase D2	0	0	7	7
NUAK family SNF1-like kinase 2	0	0	6	6
RNA cytidine acetyltransferase	0	0	7	7
Serine/threonine-protein kinase SIK2	0	0	7	7
STE20-like serine/threonine-protein kinase	0	0	7	7
Serine/threonine-protein kinase TAO3	0	0	7	7
dCTP pyrophosphatase 1	0	0	7	7
Dual specificity protein kinase CLK4	0	0	6	6
Casein kinase I isoform gamma-1	0	1	7	8
Phenylalanine--tRNA ligase beta subunit	0	0	7	7
BMP-2-inducible protein kinase	0	0	7	7
Obg-like ATPase 1	0	0	4	4
Midasin	0	0	7	7
Interleukin-1 receptor-associated kinase 4	0	0	7	7
Mitogen-activated protein kinase kinase kinase 20	0	1	7	8
Cyclin-dependent kinase 12	0	0	7	7
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	6	6
Serine/threonine-protein kinase 26	0	0	7	7
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	7	7
Serine/threonine-protein kinase NLK	0	0	7	7
5'-AMP-activated protein kinase subunit gamma-2	0	0	7	8
Serine/threonine-protein kinase TBK1	0	1	7	8
Septin-9	0	0	7	7
Ribosomal protein S6 kinase alpha-6	0	0	7	7
TRAF2 and NCK-interacting protein kinase	0	0	7	7
Serine/threonine-protein kinase TAO2	0	0	7	7
Long-chain-fatty-acid--CoA ligase 5	0	0	4	4
RAC-gamma serine/threonine-protein kinase	0	2	7	9
Serine/threonine-protein kinase SIK3	0	0	7	7
Mitogen-activated protein kinase kinase kinase 2	0	0	7	7
Thyroid hormone receptor-associated protein 3	0	0	7	7
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	7	7
Receptor-interacting serine/threonine-protein kinase 3	0	1	7	8
Serine/threonine-protein kinase MRCK beta	0	0	7	7
Interleukin-1 receptor-associated kinase 3	0	0	7	7
Casein kinase I isoform gamma-3	0	0	7	7
Mitogen-activated protein kinase kinase kinase 4	0	0	7	7
Sphingosine 1-phosphate receptor 1	0	1	2	3
RCG53912, isoform CRA_a	0	0	0	1
Sphingosine kinase 1	0	0	0	1
Sphingosine kinase 2	0	1	0	2
Sphingosine kinase 1	0	1	0	2
corticotropin-releasing hormone receptor 2	0	1	1	2
corticotropin releasing factor-binding protein	0	1	1	2
glycogen synthase kinase-3 beta isoform 1	0	0	6	6
5'-nucleotidase	0	1	0	1
Adenosine deaminase	0	0	0	2
Chain A, PROTEIN (TRANSTHYRETIN)	0	0	1	1
Chain B, PROTEIN (TRANSTHYRETIN)	0	0	1	1
Aldo-keto reductase family 1 member B10	0	2	0	2
Transient receptor potential cation channel subfamily A member 1	0	0	2	2
Transient receptor potential cation channel subfamily M member 2	0	2	0	2
Cytochrome c oxidase subunit 2	0	2	0	2
Transthyretin	0	1	2	3
Androgen receptor	0	4	1	5
Fatty acid-binding protein, intestinal	0	2	0	2
Aldo-keto reductase family 1 member B1	0	5	0	5
Aldo-keto reductase family 1 member C4	0	2	0	2
Prostaglandin G/H synthase 1	0	3	0	3
Transcription factor SOX-18	0	1	0	1
Aldo-keto reductase family 1 member C2	0	3	0	3
Aldo-keto reductase family 1 member C1	0	3	0	3
Peroxisome proliferator-activated receptor alpha	2	0	0	2
Transcriptional enhancer factor TEF-3	0	1	1	2
Nicotinate phosphoribosyltransferase	0	3	0	3
Potassium channel subfamily K member 18	0	0	1	1
Acid-sensing ion channel 5	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	0	3
glycogen synthase kinase-3 alpha	0	0	0	1
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Skn7p	0	0	0	1
pregnane X receptor	5	0	0	5
Aromatase	0	1	0	1
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Chain A, Dihydrofolate reductase	0	0	1	1
acid sphingomyelinase	4	0	0	4
Thymidylate synthase	0	4	0	4
Dihydrofolate reductase	0	4	4	9
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Solute carrier organic anion transporter family member 1A3	0	1	0	3
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Multidrug resistance associated protein	0	1	0	3
Chain A, probable fosfomycin resistance protein	0	0	1	1
Chain B, probable fosfomycin resistance protein	0	0	1	1
DNA polymerase catalytic subunit	0	1	0	1
DNA polymerase catalytic subunit	0	1	0	1
DNA polymerase alpha catalytic subunit	0	1	0	1
DNA polymerase delta catalytic subunit	0	1	0	1
NADP-dependent malic enzyme, mitochondrial	0	0	0	1
Solute carrier family 22 member 20	0	5	0	5
Prolyl 4-hydroxylase	0	1	0	1
Solute carrier family 22 member 6	0	5	0	5
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Egl nine homolog 1	0	1	1	2
Methyl-accepting chemotaxis protein NahY	0	0	1	1
Chain A, Type Iii Chloramphenicol Acetyltransferase	0	1	0	1
streptokinase A precursor	0	0	3	3
Estrogen receptor	0	0	3	3
Estrogen receptor beta	0	0	3	3
Canalicular multispecific organic anion transporter 1	0	2	0	3
large T antigen	0	2	0	2
ClpP	2	0	0	2
Transitional endoplasmic reticulum ATPase	0	1	0	1
Chain A, DEOXYNUCLEOSIDE KINASE	0	1	0	1
Equilibrative nucleoside transporter 1	0	1	0	1
Chain A, Glutamine Binding Protein	0	0	1	1
Neutral amino acid transporter A	0	2	0	2
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	2	0	2
Amino acid transporter	0	2	0	2
Chain A, Protein (aspartate Aminotransferase)	0	0	1	1
Chain A, Aspartate Aminotransferase	0	0	1	1
Solute carrier family 22 member 7	0	0	0	1
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
Chain A, Uracil Phosphoribosyltransferase	0	0	1	1
Chain B, Uracil Phosphoribosyltransferase	0	0	1	1
Chain C, Uracil Phosphoribosyltransferase	0	0	1	1
2-dehydropantoate 2-reductase	0	0	1	1
Ras-related protein Rab-7a	0	0	1	1
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9	0	2	0	2
Chain A, Breast cancer type 1 susceptibility protein	2	0	0	2
RGS12	1	0	0	1
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
DNA polymerase III, partial	4	0	0	4
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	1	0	0	1
RAF proto-oncogene serine/threonine-protein kinase	0	1	2	3
Platelet-activating factor receptor	1	0	0	1
Casein kinase II subunit alpha	0	3	2	5
Myocilin	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 4	0	1	0	1
Kinesin-like protein KIF15	0	1	0	1
Chain E, C-amp-dependent Protein Kinase	0	1	0	1
Chain I, Protein Kinase Inhibitor Peptide	0	1	0	1
Chain E, C-amp-dependent Protein Kinase	0	1	0	1
Chain E, C-amp-dependent Protein Kinase	0	1	0	1
Chain I, Protein Kinase Inhibitor Peptide	0	1	0	1
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	1	0	1
cAMP-dependent protein kinase catalytic subunit alpha	0	2	0	2
Protein kinase C gamma type	0	1	0	1
cAMP-dependent protein kinase catalytic subunit beta	0	1	0	1
cAMP-dependent protein kinase catalytic subunit alpha	0	1	1	2
Myosin light chain kinase, smooth muscle	0	1	1	2
Protein kinase C eta type	0	1	2	3
cAMP-dependent protein kinase type II-beta regulatory subunit	0	1	0	1
Casein kinase II subunit beta	0	2	0	2
MO15-related protein kinase Pfmrk	0	2	0	2
Protein kinase C epsilon type	0	2	2	4
Protein kinase C zeta type	0	1	1	2
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	1	2	3
Serine/threonine-protein kinase D1	0	1	2	3
Rho-associated protein kinase 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	4	0	4
UDP-glucuronosyltransferase 1A9	0	1	0	3
Vitamin D-binding protein	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Integrin beta-1	0	2	0	2
Integrin alpha-4	0	2	0	2
Carbonyl reductase [NADPH] 1	0	0	0	1
C-8 sterol isomerase	0	1	0	1
Kappa-type opioid receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	1	0	1
AP-2 complex subunit sigma	0	1	0	1
N-acetyltransferase Eis	0	2	0	2
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Calcitonin gene-related peptide type 1 receptor	0	1	0	1
Genome polyprotein	0	3	0	3
Sigma intracellular receptor 2	0	2	0	2
Zinc finger protein 664	0	1	0	1
Vesicular acetylcholine transporter	0	2	0	2
Transient receptor potential cation channel subfamily V member 4	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
DNA repair and recombination protein RAD54-like isoform 1	0	0	0	1
Acetylcholinesterase	0	2	0	2
Tryptophan 2,3-dioxygenase	0	1	0	1
Chain E, Fibrin beta chain	0	1	0	1
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
Mcl-1	0	1	0	1
MPI protein	0	1	0	1
Cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0	0	0	1
alkaline phosphatase, intestinal	0	0	1	1
hypothetical protein, conserved	3	0	0	3
luciferase	1	0	0	1
pyruvate kinase	4	0	0	4
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
CDK5	0	0	0	1
serine-protein kinase ATM isoform a	1	0	0	1
major prion protein preproprotein Prp precursor	0	1	0	1
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	0	2	2
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
intestinal alkaline phosphatase precursor	0	0	1	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
Tat	0	1	0	1
alkaline phosphatase, germ cell type preproprotein	0	0	1	1
endoribonuclease toxin MazF	0	0	1	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Rap guanine nucleotide exchange factor 3	2	0	0	2
Pyruvate kinase PKM	0	1	1	2
Endothelin-1 receptor	3	0	0	3
hypothetical protein CAALFM_CR05890CA	0	0	0	1
H3 histone acetyltransferase	0	0	0	1
Genome polyprotein	0	1	0	1
Cyclic GMP-AMP synthase	0	1	0	1
Toll-like receptor 9	0	1	0	1
Toll-like receptor 7	0	1	0	1
NPYLR7B	0	0	3	3
Glutamate receptor 1	1	1	0	2
Glutamate receptor 3	1	1	0	2
Glutamate receptor 4	1	1	0	2
Membrane-associated progesterone receptor component 1	0	0	3	3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	1	3	4
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	0	1	0	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	1	2	3
Cyclin-dependent kinase-like 5	0	0	4	4
Phosphatidylinositol 3-kinase regulatory subunit alpha	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	2	2	4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	1	2	3
Phosphatidylinositol 4-kinase alpha	0	1	0	1
Dual specificity mitogen-activated protein kinase kinase 4	0	0	3	3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	2	3
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Serine/threonine-protein kinase ATR	0	0	2	2
Serine/threonine-protein kinase 38	0	0	4	4
MAP kinase-activated protein kinase 3	0	0	3	3
Uncharacterized aarF domain-containing protein kinase 5	0	0	3	3
Rab-like protein 3	0	0	4	4
MAP kinase-activated protein kinase 5	0	1	6	7
Misshapen-like kinase 1	0	0	6	6
Phosphatidylinositol 3-kinase catalytic subunit type 3	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
Serine/threonine-protein kinase PAK 6	0	0	5	5
Phosphatidylinositol 4-kinase beta	0	1	2	3
Serine/threonine-protein kinase ICK	0	0	6	6
Serine/threonine-protein kinase 38-like	0	0	3	3
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	6	6
Serine/threonine-protein kinase 24	0	0	6	6
Thymidine phosphorylase	0	0	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	2
Mast/stem cell growth factor receptor Kit	0	1	3	4
Platelet-derived growth factor receptor alpha	0	1	3	4
Cytochrome P450 3A5	0	3	0	4
Solute carrier family 22 member 3	0	6	0	6
UDP-glucuronosyltransferase 1A3	0	0	0	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	2	0	2
Envelope glycoprotein	0	0	1	1
Leukotriene C4 synthase	0	0	2	2
Serine/threonine-protein kinase 25	0	0	2	2
Serine/threonine-protein kinase RIO3	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 7	0	1	2	3
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	2	3
Peripheral plasma membrane protein CASK	0	0	2	2
Serine/threonine-protein kinase DCLK1	0	0	2	2
Inhibitor of nuclear factor kappa-B kinase subunit alpha	0	0	2	2
Muscle, skeletal receptor tyrosine-protein kinase	0	0	2	2
Mitogen-activated protein kinase 13	0	1	2	3
3-phosphoinositide-dependent protein kinase 1	0	0	2	2
Mitogen-activated protein kinase kinase kinase 13	0	0	2	2
Death-associated protein kinase 3	0	0	2	2
Mitogen-activated protein kinase kinase kinase 7	0	0	2	2
NUAK family SNF1-like kinase 1	0	0	2	2
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	0	0	2	2
Tyrosine-protein kinase JAK2	0	7	5	14
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	0	0	2	2
Serine/threonine-protein kinase PAK 3	0	0	2	2
Serine/threonine-protein kinase 17B	0	0	2	2
Cyclin-dependent kinase 14	0	0	2	2
Serine/threonine-protein kinase OSR1	0	0	2	2
Serine/threonine-protein kinase Chk2	0	0	2	2
Macrophage colony-stimulating factor 1 receptor	0	1	2	3
Proto-oncogene tyrosine-protein kinase ROS	0	1	2	3
Wee1-like protein kinase 2	0	0	2	2
Uncharacterized serine/threonine-protein kinase SBK3	0	0	2	2
Insulin receptor-related protein	0	0	2	2
Vascular endothelial growth factor receptor 1	0	0	2	2
Interferon-induced, double-stranded RNA-activated protein kinase	0	0	2	2
Serine/threonine-protein kinase MAK	0	0	2	2
Cyclin-dependent kinase 11B	0	0	2	2
Fibroblast growth factor receptor 2	0	0	2	2
Receptor tyrosine-protein kinase erbB-3	0	1	2	3
Fibroblast growth factor receptor 4	0	0	2	2
Fibroblast growth factor receptor 3	0	0	2	2
Activin receptor type-2A	0	0	2	2
Ephrin type-A receptor 3	0	0	2	2
Ephrin type-A receptor 8	0	0	2	2
Leukocyte tyrosine kinase receptor	0	0	2	2
Tyrosine-protein kinase receptor UFO	0	0	2	2
Mitogen-activated protein kinase 4	0	0	2	2
G protein-coupled receptor kinase 4	0	0	2	2
Tyrosine-protein kinase receptor Tie-1	0	0	2	2
Vascular endothelial growth factor receptor 3	0	0	2	2
Vascular endothelial growth factor receptor 2	0	0	2	2
Serine/threonine-protein kinase receptor R3	0	0	3	3
Megakaryocyte-associated tyrosine-protein kinase	0	0	2	2
Tyrosine-protein kinase TXK	0	2	3	5
Tyrosine-protein kinase ZAP-70	0	0	2	2
Cyclin-dependent kinase 8	0	0	2	2
Tyrosine-protein kinase Blk	0	2	3	5
Cytoplasmic tyrosine-protein kinase BMX	0	3	3	6
cAMP-dependent protein kinase catalytic subunit PRKX	0	0	3	3
Serine/threonine-protein kinase Nek4	0	0	2	2
Death-associated protein kinase 1	0	0	2	2
Mitogen-activated protein kinase 12	0	1	2	3
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	2	3
Ephrin type-B receptor 1	0	0	2	2
Oxysterols receptor LXR-beta	0	1	0	1
Hormonally up-regulated neu tumor-associated kinase	0	0	2	2
Serine/threonine-protein kinase SIK1	0	0	2	2
Receptor-interacting serine/threonine-protein kinase 4	0	0	2	2
Cell division control protein 2 homolog	0	0	2	2
Calcium-dependent protein kinase 1	0	0	2	2
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	0	0	2	2
SRSF protein kinase 2	0	0	2	2
Mitogen-activated protein kinase kinase kinase 9	0	0	2	2
Serine/threonine-protein kinase PknB	0	0	2	2
Cyclin-dependent kinase-like 1	0	0	2	2
Angiopoietin-1 receptor	0	0	2	2
Mitogen-activated protein kinase kinase kinase 10	0	0	2	2
Tyrosine-protein kinase receptor TYRO3	0	0	2	2
Cyclin-dependent kinase 18	0	0	3	3
Tyrosine-protein kinase ITK/TSK	0	2	3	5
Myotonin-protein kinase	0	0	2	2
Mitogen-activated protein kinase kinase kinase 12	0	0	2	2
Tyrosine-protein kinase Mer	0	1	5	6
Serine/threonine-protein kinase PAK 1	0	0	2	2
cGMP-dependent protein kinase 2	0	0	2	2
Serine/threonine-protein kinase PRP4 homolog	0	0	2	2
Receptor-interacting serine/threonine-protein kinase 1	0	0	2	2
Calcium/calmodulin-dependent protein kinase type 1	0	0	2	2
Receptor tyrosine-protein kinase erbB-4	0	2	3	5
Ribosomal protein S6 kinase alpha-2	0	0	2	2
Rhodopsin kinase GRK1	0	0	2	2
NT-3 growth factor receptor	0	0	2	2
BDNF/NT-3 growth factors receptor	0	0	2	2
Mitogen-activated protein kinase 6	0	0	2	2
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	0	0	2	2
Serine/threonine-protein kinase SBK1	0	0	2	2
Mitogen-activated protein kinase kinase kinase 19	0	0	2	2
Serine/threonine-protein kinase TNNI3K	0	0	2	2
Tyrosine-protein kinase JAK2	0	0	1	1
Serine/threonine-protein kinase Nek5	0	0	2	2
Dual serine/threonine and tyrosine protein kinase	0	0	2	2
Mitogen-activated protein kinase kinase kinase 15	0	0	2	2
Serine/threonine-protein kinase tousled-like 2	0	0	2	2
Serine/threonine-protein kinase 32C	0	0	2	2
Serine/threonine-protein kinase pim-3	0	0	2	2
Serine/threonine-protein kinase VRK2	0	0	2	2
Myosin light chain kinase family member 4	0	0	2	2
Homeodomain-interacting protein kinase 1	0	0	2	2
Calcium/calmodulin-dependent protein kinase type 1D	0	0	2	2
Cyclin-dependent kinase-like 3	0	0	2	2
Serine/threonine-protein kinase BRSK2	0	0	2	2
Serine/threonine-protein kinase NIM1	0	0	2	2
Serine/threonine-protein kinase ULK2	0	0	2	2
Serine/threonine-protein kinase DCLK2	0	0	2	2
Calcium/calmodulin-dependent protein kinase kinase 1	0	0	2	2
Casein kinase I isoform alpha-like	0	0	2	2
Homeodomain-interacting protein kinase 4	0	0	2	2
Myosin-IIIa	0	0	2	2
Ankyrin repeat and protein kinase domain-containing protein 1	0	0	2	2
Serine/threonine-protein kinase Nek11	0	0	2	2
Serine/threonine-protein kinase BRSK1	0	0	2	2
Serine/threonine-protein kinase 35	0	0	2	2
Rhodopsin kinase GRK7	0	0	2	2
Serine/threonine-protein kinase 32A	0	0	2	2
Myosin-IIIb	0	0	2	2
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	0	2	2
Cyclin-dependent kinase-like 2	0	0	2	2
Serine/threonine-protein kinase Sgk3	0	0	2	2
Atypical kinase COQ8B, mitochondrial	0	0	2	2
Calcium/calmodulin-dependent protein kinase type 1G	0	0	4	4
Cyclin-dependent kinase 15	0	0	2	2
SRSF protein kinase 1	0	0	2	2
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	0	0	2	2
Serine/threonine-protein kinase RIO1	0	0	2	2
MAP kinase-interacting serine/threonine-protein kinase 1	0	0	2	2
Serine/threonine-protein kinase RIO2	0	0	2	2
Cyclin-dependent kinase 19	0	0	2	2
Transient receptor potential cation channel subfamily M member 6	0	0	2	2
Testis-specific serine/threonine-protein kinase 1	0	0	2	2
Serine/threonine-protein kinase 33	0	0	2	2
Serine/threonine-protein kinase DCLK3	0	0	2	2
Myosin light chain kinase 2, skeletal/cardiac muscle	0	0	2	2
Homeodomain-interacting protein kinase 2	0	0	2	2
Tyrosine-protein kinase Srms	0	0	2	2
Homeodomain-interacting protein kinase 3	0	0	2	2
Serine/threonine-protein kinase PLK3	0	0	2	2
MAP kinase-interacting serine/threonine-protein kinase 2	0	0	2	2
Serine/threonine-protein kinase Nek6	0	0	2	2
SNF-related serine/threonine-protein kinase	0	0	2	2
Serine/threonine-protein kinase LATS2	0	0	2	2
Serine/threonine-protein kinase 36	0	0	2	2
Isoleucine--tRNA ligase, mitochondrial	0	0	3	3
Serine/threonine-protein kinase 32B	0	0	2	2
Serine/threonine-protein kinase PLK2	0	0	2	2
Serine/threonine-protein kinase MARK1	0	0	2	2
Serine/threonine-protein kinase pim-2	0	0	2	2
Serine/threonine-protein kinase PAK 5	0	0	2	2
eIF-2-alpha kinase GCN2	0	0	2	2
Serine/threonine-protein kinase 17A	0	0	2	2
STE20/SPS1-related proline-alanine-rich protein kinase	0	0	2	2
Ephrin type-A receptor 6	0	0	2	2
Death-associated protein kinase 2	0	0	2	2
Serine/threonine-protein kinase tousled-like 1	0	0	2	2
ALK tyrosine kinase receptor	0	0	2	2
SRSF protein kinase 3	0	0	2	2
Cyclin-dependent kinase 11A	0	0	2	2
Aurora kinase C	0	0	2	2
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	0	2	2
Microtubule-associated serine/threonine-protein kinase 1	0	0	2	2
Chain A, PROTEIN (PROTEASE)	0	1	0	1
Chain B, PROTEIN (PROTEASE)	0	1	0	1
Chain A, PROTEIN (PROTEASE)	0	1	0	1
Chain B, PROTEIN (PROTEASE)	0	1	0	1
Chain A, HIV-1 PROTEASE	0	1	0	1
Chain B, HIV-1 PROTEASE	0	1	0	1
Chain A, HIV-II PROTEASE	0	1	0	1
Chain B, HIV-II PROTEASE	0	1	0	1
Chain A, POL polyprotein	0	0	1	1
Chain B, POL polyprotein	0	0	1	1
Chain A, POL polyprotein	0	0	1	1
Chain B, POL polyprotein	0	0	1	1
Chain A, POL polyprotein	0	0	1	1
Chain B, POL polyprotein	0	0	1	1
Chain A, POL polyprotein	0	0	1	1
Chain B, POL polyprotein	0	0	1	1
Chain A, protease RETROPEPSIN	0	1	0	1
Chain B, protease RETROPEPSIN	0	1	0	1
Chain A, protease RETROPEPSIN	0	1	0	1
Chain B, protease RETROPEPSIN	0	1	0	1
Chain A, protease RETROPEPSIN	0	1	0	1
Chain B, protease RETROPEPSIN	0	1	0	1
Chain A, POL polyprotein	0	2	0	2
Chain B, POL polyprotein	0	2	0	2
Chain A, POL polyprotein	0	2	0	2
Chain B, POL polyprotein	0	2	0	2
Chain A, HIV-1 protease	0	1	0	1
Chain B, HIV-1 protease	0	1	0	1
Chain A, Pol polyprotein	0	1	0	1
Chain B, Pol polyprotein	0	1	0	1
Chain A, Pol polyprotein	0	1	0	1
Chain B, Pol polyprotein	0	1	0	1
Chain A, Pol polyprotein	0	1	0	1
Chain B, Pol polyprotein	0	1	0	1
Chain A, Pol polyprotein	0	1	0	1
Chain B, Pol polyprotein	0	1	0	1
Chain A, Hiv-1 Protease	0	1	0	1
Chain B, Hiv-1 Protease	0	1	0	1
Chain A, Hiv-1 Protease	0	1	0	1
Chain B, Hiv-1 Protease	0	1	0	1
Chain A, Hiv-1 Protease	0	1	0	1
Chain B, Hiv-1 Protease	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Gag polyprotein	0	1	0	1
Gag-Pol polyprotein	0	3	0	3
Thromboxane-A synthase	0	3	0	3
Gag-Pol polyprotein	0	3	0	3
Thromboxane-A synthase	0	0	0	2
Protease	0	1	0	1
Chain B, Pulmonary surfactant-associated protein D	0	1	0	1
Chain A, Pulmonary surfactant-associated protein D	0	1	0	1
Sodium/myo-inositol cotransporter 2	0	1	0	1
Chain A, Acetylcholinesterase	0	1	0	1
interferon gamma precursor	0	0	0	3
Interstitial collagenase	0	2	0	2
Acetylcholinesterase	0	1	0	1
Ornithine decarboxylase	0	0	0	1
Adenosine receptor A3	0	5	0	5
Retinoic acid receptor alpha	0	1	0	1
Retinoic acid receptor gamma	0	1	0	1
Retinoic acid receptor beta	0	1	0	1
Cellular retinoic acid-binding protein 2	0	0	1	1
Retinoic acid receptor RXR-beta	0	1	0	1
Retinoic acid receptor RXR-gamma	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	1
Cellular retinoic acid-binding protein 1	0	0	1	1
Olfactory receptor 51E2	0	1	0	1
5-hydroxytryptamine receptor 1B	0	1	0	1
Synaptic vesicular amine transporter	0	2	0	2
Hsf1 protein	0	0	1	1
Capsid protein	0	1	2	3
matrix metalloproteinase 1, partial	0	0	1	1
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	2	0	2
Amine oxidase [flavin-containing] A	0	2	0	2
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	3	1	4
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	2	0	2
Bromodomain-containing protein 4	0	1	0	1
DNA-binding protein Ikaros	0	0	2	7
DNA damage-binding protein 1	0	3	2	5
Zinc finger protein Aiolos	0	0	2	2
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	4	0	4
Intestinal-type alkaline phosphatase	0	3	0	3
Large neutral amino acids transporter small subunit 1	0	3	0	4
Phospholipase A-2-activating protein	0	3	0	3
Alkaline phosphatase, placental type	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	3	0	3
Intestinal-type alkaline phosphatase	0	2	0	2
5'-nucleotidase	0	2	0	2
Chain A, protease	0	1	0	1
Chain B, protease	0	1	0	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, PROTEASE RETROPEPSIN	0	1	0	1
Chain B, PROTEASE RETROPEPSIN	0	1	0	1
Chain A, Protease Retropepsin	0	1	0	1
Chain B, Protease Retropepsin	0	1	0	1
Chain A, Protease Retropepsin	0	1	0	1
Chain B, Protease Retropepsin	0	1	0	1
Gag-Pol polyprotein	0	2	0	2
CAAX prenyl protease 1 homolog	0	1	0	1
Plasmepsin V	0	2	0	2
C-C chemokine receptor type 5	0	1	2	4
C-C chemokine receptor type 5	0	1	0	1
C-C chemokine receptor type 5	0	1	0	1
Cysteinyl leukotriene receptor 1	0	1	0	1
Myc proto-oncogene protein	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Adenosine receptor A2a	0	3	0	3
Adenosine receptor A1	0	3	0	3
Histidine-rich protein PFHRP-II	0	1	0	1
Glycine receptor subunit alpha-1	0	0	2	2
Large neutral amino acids transporter small subunit 1	0	2	0	2
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	3	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	3	0	3
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Bifunctional purine biosynthesis protein ATIC	0	3	0	3
Reduced folate transporter	0	2	0	2
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	6	6
Glucocorticoid receptor	0	7	2	14
Glycine receptor subunit alpha-1	0	6	0	6
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Endothelin-1 receptor	0	1	0	1
Type-2 angiotensin II receptor	0	3	0	3
Angiotensin-converting enzyme	0	2	0	2
5-hydroxytryptamine receptor 3B	0	2	0	2
G-protein coupled receptor	0	1	0	1
isocitrate dehydrogenase 1, partial	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
heat shock protein 90, putative	0	0	0	1
methionyl-tRNA synthetase, putative	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	2	0	2
UDP-glucuronosyltransferase 2B10	0	2	0	2
Chain A, Probable serine/threonine-protein kinase pknB	0	1	0	1
LANA	0	0	0	1
phospholipase A2, group III	0	1	0	1
histone-lysine N-methyltransferase NSD2 isoform 1	0	0	0	1
protein AF-9 isoform a	0	0	0	1
dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	0	1
rac GTPase-activating protein 1 isoform a	0	1	0	1
pyruvate kinase PKM isoform b	2	0	0	2
Glycoprotein hormones alpha chain	1	0	0	1
Ornithine decarboxylase	2	0	0	2
NEDD8-activating enzyme E1 regulatory subunit	0	0	1	1
Casein kinase II subunit alpha 3	0	1	0	1
NEDD8-activating enzyme E1 catalytic subunit	0	0	1	1
P2Y purinoceptor 12	0	1	0	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Nuclear receptor corepressor 1	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
Chain A, Inosine-5'-Monophosphate Dehydrogenase 2	0	1	0	1
Inosine-5'-monophosphate dehydrogenase 1	0	2	0	2
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Inosine-5'-monophosphate dehydrogenase	0	1	0	2
UDP-glucuronosyltransferase 1A7	0	0	0	1
UDP-glucuronosyltransferase 1A10	0	0	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Sialidase-4	0	1	0	1
Sialidase-1	0	1	0	1
Sialidase-3	0	1	0	1
Sialidase-2	0	1	0	1
Voltage-dependent L-type calcium channel subunit beta-4	0	1	0	1
Voltage-dependent P/Q-type calcium channel subunit alpha-1A	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1G	0	1	0	1
Voltage-dependent calcium channel gamma-3 subunit	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1H	0	1	0	1
Cannabinoid receptor 1	0	2	0	2
Voltage-dependent L-type calcium channel subunit beta-3	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Voltage-dependent calcium channel gamma-7 subunit	0	1	0	1
Voltage-dependent L-type calcium channel subunit beta-1	0	1	0	1
Voltage-dependent calcium channel gamma-1 subunit	0	1	0	1
Voltage-dependent L-type calcium channel subunit beta-2	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Voltage-dependent R-type calcium channel subunit alpha-1E	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-4	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Voltage-dependent calcium channel subunit alpha-2/delta-3	0	1	0	1
Voltage-dependent calcium channel gamma-8 subunit	0	1	0	1
Voltage-dependent calcium channel gamma-6 subunit	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-2	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1I	0	1	0	1
Voltage-dependent calcium channel gamma-4 subunit	0	1	0	1
Voltage-dependent calcium channel gamma-5 subunit	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	0	1	0	1
pyruvate kinase PKM isoform a	2	0	0	2
Signal transducer and activator of transcription 3	0	1	0	1
Pyruvate-flavodoxin oxidoreductase	0	1	0	1
Anoctamin-1	0	1	0	1
Translocator protein	0	1	0	1
Lysine-specific demethylase 4C	0	2	0	2
polyadenylate-binding protein 1	0	2	0	2
bcl-2-related protein A1	0	2	0	2
Genome polyprotein	0	1	0	1
Tubulin alpha-1A chain	0	2	2	5
Tubulin beta chain	0	2	2	4
Tubulin beta-4A chain	0	2	2	6
Integrin alpha-V	0	1	0	1
Tubulin beta chain	0	2	2	6
Tubulin alpha-3C chain	0	2	2	6
Botulinum neurotoxin type A	0	1	0	1
Cholecystokinin receptor type A	0	2	0	2
Tubulin alpha-1B chain	0	2	2	6
Tubulin alpha-4A chain	0	2	2	6
Tubulin beta-4B chain	0	2	2	6
Tubulin beta-3 chain	0	3	2	7
Tubulin beta-2A chain	0	2	2	6
Beta-tubulin	0	1	0	1
Tubulin beta-8 chain	0	2	2	6
Tubulin alpha-3E chain	0	2	2	6
Tubulin alpha-1A chain	0	2	2	6
Tubulin alpha-1C chain	0	2	2	6
Tubulin beta-6 chain	0	2	2	6
Tubulin beta-2B chain	0	2	2	6
Tubulin beta-1 chain	0	2	2	6
Nucleotide-binding oligomerization domain-containing protein 2	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	10	0	11
Testosterone 17-beta-dehydrogenase 3	0	1	0	1
Putative nucleoside diphosphate kinase	0	0	1	1
Nucleoside diphosphate kinase B	0	0	1	1
G1/S-specific cyclin-E1	0	1	0	1
Nuclear receptor subfamily 4 group A member 3	0	1	0	1
Peroxiredoxin-like 2A	0	1	0	1
Platelet glycoprotein VI	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Plasma kallikrein	0	0	0	1
E3 ubiquitin-protein ligase XIAP	0	1	0	1
SLC16A10 protein	0	0	0	1
Monocarboxylate transporter 10	0	0	0	1
Gamma-aminobutyric acid	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
PAX8	0	0	0	1
nuclear receptor subfamily 0 group B member 1	0	1	0	1
steroidogenic factor 1	0	1	0	1
Regulatory protein E2	0	0	1	1
Regulatory protein E2	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Calcium-activated potassium channel subunit alpha-1	0	1	0	1
Programmed cell death protein 1	0	1	0	1
E3 ubiquitin-protein ligase ZFP91	0	0	0	1
Programmed cell death 1 ligand 1	0	1	0	1
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
runt-related transcription factor 1 isoform AML1b	1	0	0	1
core-binding factor subunit beta isoform 2	1	0	0	1
Cholinesterase	0	3	0	3
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	1	0	1
dual specificity protein phosphatase 3	0	1	0	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
tyrosine-protein phosphatase non-receptor type 22 isoform 1	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Beta-hexosaminidase subunit alpha	0	1	0	2
Beta-hexosaminidase subunit beta	0	1	0	1
Substance-K receptor	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Trace amine-associated receptor 5	0	0	1	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Multidrug and toxin extrusion protein 1	0	1	0	1
NS5	0	0	1	1
Polymerase basic protein 2	0	0	1	1
RNA-directed RNA polymerase catalytic subunit	0	0	1	1
Polymerase acidic protein	0	0	2	2
Adenosylhomocysteinase	0	0	0	2
Adenosine receptor A1	0	1	0	1
Genome polyprotein	0	0	1	1
Chain A, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain B, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain H, Immunoglobulin Igg1 Heavy chain	0	0	1	1
Chain L, Immunoglobulin Igg1 Lambda Light Chain	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain C, DODECIN	0	0	1	1
Chain E, DODECIN	0	0	1	1
thyrotropin-releasing hormone receptor	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
Riboflavin-binding protein	0	1	1	2
DNA-directed RNA polymerase subunit beta	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	6	0	6
NH(3)-dependent NAD(+) synthetase	0	1	0	1
Arylacetamide deacetylase	0	1	0	2
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	1	0	1
Glutathione S-transferase omega-1	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
ubiquitin-conjugating enzyme E2 N	0	2	0	2
Diacylglycerol kinase alpha	0	1	0	1
Chain A, HIV-1 PROTEASE	0	1	0	1
Chain B, HIV-1 PROTEASE	0	1	0	1
Chain A, Endothiapepsin	0	1	0	1
Chain A, Endothiapepsin	0	1	0	1
Vasopressin V1a receptor	0	2	0	2
Sodium/bile acid cotransporter	0	2	0	2
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
Polyphenol oxidase 2	0	1	0	2
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Eukaryotic translation initiation factor 4E	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	4	2	6
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	2	2
Peptidyl-prolyl cis-trans isomerase FKBP5	0	2	0	2
Programmed cell death protein 4	0	0	1	1
Serine/threonine-protein kinase mTOR	0	1	0	1
C-X-C chemokine receptor type 5 isoform 1	0	1	0	1
C-C chemokine receptor type 6	0	1	0	1
apelin receptor	0	1	0	1
Endoglycoceramidase II	0	0	0	1
Protein kinase C alpha type	0	1	0	1
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Protein kinase C eta type	0	1	0	1
Protein kinase C theta type	0	1	0	1
Sphingosine 1-phosphate receptor 2	0	1	1	2
Sphingosine 1-phosphate receptor 4	0	1	1	2
Sphingosine 1-phosphate receptor 3	0	1	1	2
Sphingosine 1-phosphate receptor 5	0	1	1	2
Chain A, Ribosomal protein S6 kinase alpha-1	0	1	0	1
Chain X, Tyrosine-protein kinase Lyn	0	1	0	1
Chain A, Dual specificity protein kinase TTK	0	0	1	1
Chain A, Dual specificity protein kinase TTK	0	0	1	1
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
Thymidine kinase, cytosolic	0	1	0	2
Chain A, Glutathione S-transferase	0	1	0	1
Tumor necrosis factor	0	0	1	1
Fibroblast growth factor 1	0	0	1	1
Flavin reductase (NADPH)	0	0	1	1
Cystine/glutamate transporter	0	1	0	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Adenylate kinase isoenzyme 1	0	0	0	1
Dihydroorotate dehydrogenase	0	1	0	1
Stromal interaction molecule 1	0	1	0	1
Dihydroorotate dehydrogenase	0	2	0	2
Calcium release-activated calcium channel protein 1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
Cytochrome P450 2B1	0	1	0	1
Chain A, Tyrosine-protein kinase	0	1	0	1
Chain A, Tyrosine-protein kinase	0	1	0	1
Chain A, Tyrosine-protein kinase JAK2	0	1	0	1
Serine/threonine-protein kinase Sgk1	0	1	0	1
Tubulin alpha-1A chain	0	0	1	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	0	1	0	1
Tyrosine-protein kinase JAK3	0	1	0	1
Tyrosine-protein kinase JAK2	0	1	0	1
Tyrosine-protein kinase JAK3	0	1	0	1
phospholipase A2 precursor	0	1	0	1
cysteine protease ATG4B isoform a	0	1	0	1
Hypoxia-inducible factor 1-alpha	0	1	1	2
Endothelial PAS domain-containing protein 1	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	1	0	1
Adenosylhomocysteinase	0	1	0	1
RNA-directed RNA polymerase	0	1	1	2
Sterol 14-alpha-demethylase	0	0	1	1
14-alpha sterol demethylase	0	0	1	1
Cholesterol side-chain cleavage enzyme, mitochondrial	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Cytochrome P450 144	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Sterol 14-alpha demethylase	0	0	1	1
14-alpha sterol demethylase	0	0	1	1
14-alpha sterol demethylase	0	0	1	1
Adenosine receptor A2b	0	1	0	1
Tyrosinase	0	1	0	1
Phosphoglycerate mutase 1	0	1	0	1
Ectonucleoside triphosphate diphosphohydrolase 1	0	0	0	1
DNA polymerase beta	0	1	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	1	0	2
Thymidine kinase	0	1	0	2
Aspartate aminotransferase, cytoplasmic	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Leukoencephalopathy, Progressive Multifocal

Synonyms(1)

Research Excerpts

Overview

Context

Actions

Treatment

Research

Studies (753)

Protein Targets (2,177)

Leukoencephalopathy, Progressive Multifocal

Synonyms(1)

Research Excerpts

Overview

Context

Actions

Treatment

Research

Studies (753)

Drugs Studied (249)

Protein Targets (2,177)