Page last updated: 2024-08-05 13:19:21
maytansinoid
Any member of the group of 19-membered lactams that is maytansine or structurally related to it. Maytansinoids have been isolated from members of the higher plant families Celastraceae, Rhamnaceae, and Euphorbiaceae, as well as some mosses and certain Actinomycetes, but the term is used to cover both naturally occurring compounds and their semisynthetic derivatives.
ChEBI ID: 82760
Members (1)
| Member | Definition | Role |
|---|
| maytansine | An organic heterotetracyclic compound and 19-membered macrocyclic lactam antibiotic originally isolated from the Ethiopian shrub Maytenus serrata but also found in other Maytenus species. It exhibits cytotoxicity against many tumour cell lines. | maytansine |
Research
Studies (785)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|
| pre-1990 | 92 (11.72) | 18.7374 |
| 1990's | 24 (3.06) | 18.2507 |
| 2000's | 62 (7.90) | 29.6817 |
| 2010's | 482 (61.40) | 24.3611 |
| 2020's | 125 (15.92) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|
| Trials | 96 (11.78%) | 5.53% |
| Reviews | 125 (15.34%) | 6.00% |
| Case Studies | 40 (4.91%) | 4.05% |
| Observational | 4 (0.49%) | 0.25% |
| Other | 550 (67.48%) | 84.16% |