Page last updated: 2024-11-07

Prothioconazole-desthio

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Prothioconazole-desthio is a fungicide that is a derivative of prothioconazole. It is a broad-spectrum fungicide that is effective against a wide range of fungal diseases. It is used to control diseases in a variety of crops, including wheat, barley, rice, and soybeans. Prothioconazole-desthio works by inhibiting the biosynthesis of ergosterol, a key component of fungal cell membranes. This disrupts the fungal cell's ability to grow and reproduce. It is studied due to its potential to be a more effective fungicide than prothioconazole. The synthesis of Prothioconazole-desthio involves the use of a chemical reaction to create a new compound from the starting material. It is important because it can protect crops from fungal diseases, which can lead to increased yields and profits for farmers.'

prothioconazole-desthio: desulfurization metabolite of prothioconazole [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID119361
CHEMBL ID2288018
CHEBI ID177046
SCHEMBL ID2491761

Synonyms (35)

Synonym
120983-64-4
prothioconazole-desthio
2-(1-chlorocyclopropyl)-1-(2-chlorophenyl)-3-(1,2,4-triazol-1-yl)propan-2-ol
CHEBI:177046
sxx 0665
y3ex17303q ,
1h-1,2,4-triazole-1-ethanol, alpha-(1-chlorocyclopropyl)-alpha-((2-chlorophenyl)methyl)-
alpha-(1-chlorocyclopropyl)-alpha-((2-chlorophenyl)methyl)-1h-1,2,4-triazole-1-ethanol
unii-y3ex17303q
2-(1-chlorocyclopropyl)-1-(2-chlorophenyl)-3-(1h-1,2,4-triazol-1-yl)propan-2-ol
1h-1,2,4-triazole-1-ethanol, .alpha.-(1-chlorocyclopropyl)-.alpha.-[(2-chlorophenyl)methyl]-
CHEMBL2288018
HHUQPWODPBDTLI-UHFFFAOYSA-N
2-(1-chloro-cyclopropyl)-1-(2-chlorophenyl)-3-(1,2,4-triazol-1-yl)-propan-2-ol
2-(1-chloro-cyclopropyl)-1-(2-chlorophenyl)-3-(1h-1,2,4-triazol-1yl)-propan-2-ol
SCHEMBL2491761
cas-120983-64-4
2-(1-chlorocyclopropyl)-1-(2-chlorophenyl)-3-(1h-1,2,4-triazol-1-yl)-2-propanol
NCGC00357029-01
tox21_303715
dtxsid3044338 ,
dtxcid1024338
.alpha.-(1-chlorocyclopropyl)-.alpha.-((2-chlorophenyl)methyl)-1h-1,2,4-triazole-1-ethanol
sxx-0665
1h-1,2,4-triazole-1-ethanol, .alpha.-(1-chlorocyclopropyl)-.alpha.-((2-chlorophenyl)methyl)-
prothioconazole-desthio, (+/-)-
prothioconazole tp2
m04 prothioconazole-desthio
alpha-(1-chlorocyclopropyl)-alpha-o(2-chlorophenyl)methyl-1h-1,2,4-triazole-1-ethanol
E78392
Q27294222
BS-50606
CS-0161674
EN300-21836684
1ST21190
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
organochlorine compoundAn organochlorine compound is a compound containing at least one carbon-chlorine bond.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (12)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
RAR-related orphan receptor gammaMus musculus (house mouse)Potency40.38040.006038.004119,952.5996AID1159521; AID1159523
GLI family zinc finger 3Homo sapiens (human)Potency14.23120.000714.592883.7951AID1259369; AID1259392
AR proteinHomo sapiens (human)Potency29.50610.000221.22318,912.5098AID1259243; AID1259247
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency27.30600.000657.913322,387.1992AID1259378
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency35.85580.001022.650876.6163AID1224838; AID1224839
progesterone receptorHomo sapiens (human)Potency9.68850.000417.946075.1148AID1346795
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency52.63720.001530.607315,848.9004AID1224841; AID1224848; AID1224849; AID1259401; AID1259403
pregnane X nuclear receptorHomo sapiens (human)Potency34.37620.005428.02631,258.9301AID1346982
estrogen nuclear receptor alphaHomo sapiens (human)Potency69.04470.000229.305416,493.5996AID1259244; AID1259248
Histone H2A.xCricetulus griseus (Chinese hamster)Potency126.79300.039147.5451146.8240AID1224845
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency76.95880.001557.789015,848.9004AID1259244
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency76.95880.001551.739315,848.9004AID1259244
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Ceullar Components (1)

Processvia Protein(s)Taxonomy
plasma membraneGlutamate receptor 2Rattus norvegicus (Norway rat)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (9)

Assay IDTitleYearJournalArticle
AID1112403Fungicidal activity against Zymoseptoria tritici isolate R03-54 without 120 bp insertion expressing CYP51 variant with combination of L50S, S188N, I381V, deltaY459/G460 and N513K mutations assessed as fungal growth inhibition2012Pest management science, Jul, Volume: 68, Issue:7
Overexpression of the sterol 14α-demethylase gene (MgCYP51) in Mycosphaerella graminicola isolates confers a novel azole fungicide sensitivity phenotype.
AID1112404Fungicidal activity against Zymoseptoria tritici isolate R03-29 without 120 bp insertion expressing CYP51 variant with combination of L50S, S188N, I381V, deltaY459/G460 and N513K mutations assessed as fungal growth inhibition2012Pest management science, Jul, Volume: 68, Issue:7
Overexpression of the sterol 14α-demethylase gene (MgCYP51) in Mycosphaerella graminicola isolates confers a novel azole fungicide sensitivity phenotype.
AID1112402Fungicidal activity against Zymoseptoria tritici isolate R10-13 without 120 bp insertion expressing CYP51 variant with combination of L50S, S188N, I381V, deltaY459/G460 and N513K mutations assessed as fungal growth inhibition2012Pest management science, Jul, Volume: 68, Issue:7
Overexpression of the sterol 14α-demethylase gene (MgCYP51) in Mycosphaerella graminicola isolates confers a novel azole fungicide sensitivity phenotype.
AID1112405Fungicidal activity against Zymoseptoria tritici isolate IPO323 without 120 bp insertion expressing wild type CYP51 assessed as fungal growth inhibition2012Pest management science, Jul, Volume: 68, Issue:7
Overexpression of the sterol 14α-demethylase gene (MgCYP51) in Mycosphaerella graminicola isolates confers a novel azole fungicide sensitivity phenotype.
AID1112398Fungicidal activity against Zymoseptoria tritici isolate OP7 with 120 bp insertion expressing CYP51 variant with combination of L50S, S188N, I381V, deltaY459/G460 and N513K mutations assessed as fungal growth inhibition2012Pest management science, Jul, Volume: 68, Issue:7
Overexpression of the sterol 14α-demethylase gene (MgCYP51) in Mycosphaerella graminicola isolates confers a novel azole fungicide sensitivity phenotype.
AID1112399Fungicidal activity against Zymoseptoria tritici isolate TAG1-18 with 120 bp insertion expressing CYP51 variant with combination of L50S, S188N, I381V, deltaY459/G460 and N513K mutations assessed as fungal growth inhibition2012Pest management science, Jul, Volume: 68, Issue:7
Overexpression of the sterol 14α-demethylase gene (MgCYP51) in Mycosphaerella graminicola isolates confers a novel azole fungicide sensitivity phenotype.
AID1112400Fungicidal activity against Zymoseptoria tritici isolate V18 with 120 bp insertion expressing CYP51 variant with combination of L50S, S188N, I381V, deltaY459/G460 and N513K mutations assessed as fungal growth inhibition2012Pest management science, Jul, Volume: 68, Issue:7
Overexpression of the sterol 14α-demethylase gene (MgCYP51) in Mycosphaerella graminicola isolates confers a novel azole fungicide sensitivity phenotype.
AID1112397Fungicidal activity against Zymoseptoria tritici isolate TAG74-3 with 120 bp insertion expressing CYP51 variant with combination of L50S, S188N, I381V, deltaY459/G460 and N513K mutations assessed as fungal growth inhibition2012Pest management science, Jul, Volume: 68, Issue:7
Overexpression of the sterol 14α-demethylase gene (MgCYP51) in Mycosphaerella graminicola isolates confers a novel azole fungicide sensitivity phenotype.
AID1112401Fungicidal activity against Zymoseptoria tritici isolate OP6 without 120 bp insertion expressing CYP51 variant with combination of L50S, S188N, I381V, deltaY459/G460 and N513K mutations assessed as fungal growth inhibition2012Pest management science, Jul, Volume: 68, Issue:7
Overexpression of the sterol 14α-demethylase gene (MgCYP51) in Mycosphaerella graminicola isolates confers a novel azole fungicide sensitivity phenotype.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (7.69)24.3611
2020's12 (92.31)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 35.31

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index35.31 (24.57)
Research Supply Index2.64 (2.92)
Research Growth Index6.13 (4.65)
Search Engine Demand Index40.31 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (35.31)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other13 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]