triazoles has been researched along with Experimental Neoplasms in 69 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 27 (39.13) | 18.7374 |
1990's | 4 (5.80) | 18.2507 |
2000's | 8 (11.59) | 29.6817 |
2010's | 27 (39.13) | 24.3611 |
2020's | 3 (4.35) | 2.80 |
Authors | Studies |
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Cai, KY; He, XH; Li, ZW; Liu, KQ; Sun, XY; Wang, X; Zhao, YC; Zhi, TX | 1 |
Hu, R; Liu, ZH; Shi, YJ; Wang, NY; Wang, WL; Xiao, KJ; Xu, Y; Yu, LT; Zhu, YX; Zuo, WQ | 1 |
Bugide, S; Green, MR; Gupta, R; Wajapeyee, N | 1 |
Gu, LQ; Hu, MH; Huang, ZS; Kuang, GT; Lin, SL; Ou, TM; Peng, W; Su, XX; Tan, JH; Wang, H; Wang, SK; Zeng, DY; Zhang, Q | 1 |
Caretti, G; Costelli, P; Dae Ko, K; Fenizia, C; Filippakopoulos, P; Fittipaldi, R; Hatakeyama, S; Merigliano, S; Pierobon, ES; Pin, F; Sandri, M; Sartorelli, V; Sartori, R; Segatto, M; Sperti, C; Zanchettin, G; Zare, H | 1 |
Jia, Y; Jian, W; Jin, H; Lin, R; Si, L; Yang, S; Yu, Q | 1 |
Chelvanambi, M; Fabian, KPL; Hong, CS; Lang, S; Ludwig, S; Razzo, BM; Storkus, WJ; Whiteside, TL | 1 |
Cobb, MH; Ding, Q; Hu, R; Huffman, KE; Johnson, JE; Minna, JD; Savage, TK; Wang, XD; Williams, N; Yu, Y | 1 |
Jiang, CS; Li, H; Li, YP; Lu, SM; Wang, XM; Xu, J; Yang, GD; Zhang, SQ | 1 |
Beavis, PA; Chow, MT; Darcy, PK; Devaud, C; Divisekera, U; Dwyer, K; John, LB; Paget, C; Smyth, MJ; Stagg, J | 1 |
Duan, YC; Li, JF; Liu, HM; Lv, WL; Ma, JL; Mobley, D; Wang, JW; Wang, MM; Wang, ZR; Xu, RM; Ye, XW; Zhao, W; Zheng, YC; Zhu, S; Zhu, YY; Zi, X | 1 |
Bejot, R; Goggi, J; Moonshi, SS; Robins, EG | 1 |
Bradner, JE; Castillo-Martin, M; Cho, H; Cordon-Cardo, C; Herzka, T; Qi, J; Robinson, BD; Trotman, LC; Wilkinson, JE; Zheng, W | 1 |
Currie, RA; Goetz, AK; Goodman, JI; Omiecinski, CJ; Peffer, RC | 1 |
Atwood, SX; Balansay, B; Bandopadhayay, P; Bergthold, G; Beroukhim, R; Bradner, JE; Chen, S; Cheshier, SH; Cho, YJ; Gholamin, S; Lee, A; Link, BA; Masoud, S; Mitra, S; Monje, M; Nguyen, B; Oh, S; Oro, AE; Ponnuswami, A; Qi, J; Schubert, S; Tang, JY; Tang, Y; Vue, N; Wechsler-Reya, R; Whitson, RJ; Willardson, MI; Woo, P; Yu, F | 1 |
Chen, LK; Chen, WQ; Chen, ZS; Fu, LW; Huang, ZC; Talele, TT; Tang, SJ; To, KK; Wang, F; Wang, XK; Zhang, YK | 1 |
Li, H; Sun, Y; Xu, F | 1 |
Annamalai, P; Gavara, G; Hiriyan, J; Natesan, S; Sambasivam, G; Shivarudraiah, P; Sukumaran, SK | 1 |
Albert, ML; Barreira da Silva, R; Fiette, L; Ingersoll, MA; Laird, ME; Yatim, N | 1 |
Chaimovitz, C; Douvdevani, A; Eini, H; Frishman, V; Kachko, L; Lewis, EC; Yulzari, R | 1 |
Attiyeh, EF; Carol, H; Gorlick, R; Houghton, PJ; Kang, MH; Keir, ST; Kolb, EA; Kurmasheva, RT; Landesman, Y; Lock, R; Lyalin, D; Maris, JM; Reynolds, CP; Shacham, S; Smith, MA; Wu, J | 1 |
Ahn, HY; Chung, KH; Kim, HR; Oh, SM; Park, YJ | 1 |
Althaf Hussain, SK; Kumara Swamy, B; Narsimha, S; Satheesh Kumar, N; Srinivasa Rao, M; Vasudeva Reddy, N | 1 |
Bradner, JE; DeAngelo, SL; Dhe-Paganon, S; Paulk, J; Roberts, JM; Scott, TG; Seo, HS; Souza, A; Tanaka, M | 1 |
Atadja, P; Chan, H; Chen, Z; Chuai, S; Fang, D; Fei, Q; Feng, L; Gao, Y; Ge, H; Ge, X; Gu, J; Huang, Y; Li, E; Li, G; Li, L; Lin, Y; Lingel, A; Liu, Y; Luo, F; Oyang, C; Qi, W; Shi, M; Teng, L; Wang, L; Wang, Y; Wang, Z; Yu, Y; Yu, Z; Zeng, C; Zeng, J; Zhang, C; Zhang, H; Zhang, J; Zhang, L; Zhang, M; Zhang, Q; Zhao, K; Zhao, M; Zhou, S | 1 |
Gaballah, K; Hills, A; Oakley, R; Partridge, M; Ryan, A | 1 |
Iovanna, JL; Liu, Y; Peng, L; Qu, F; Rocchi, P; Wan, J; Wang, M; Xia, Y | 1 |
Arnesano, A; Benvenuti, S; Comoglio, PM; Gentile, A; Lazzari, L; Li Chiavi, G | 1 |
Barsoum, J; Bates, RC; Blackman, RK; Foley, KP; Korbut, T; Koya, K; Liu, Y; Proia, DA; Rosenberg, AF; Sang, J; Smith, D; Zhou, D | 1 |
Bussink, J; Dubois, LJ; Janssen, MH; Kolb, HC; Lambin, P; Lieuwes, NG; Ollers, MC; Peeters, WJ; van der Kogel, A; van Dongen, GA; Walsh, JC; Windhorst, AD | 1 |
Billups, CA; Carol, H; Gorlick, R; Houghton, PJ; Kang, MH; Keir, ST; Kolb, EA; Kurmasheva, RT; Lock, RB; Maris, JM; Reynolds, CP; Smith, MA | 1 |
Blanco, JR; Martínez, A; Ochoa-Callejero, L; Oteo, JA; Pérez-Martínez, L; Rubio-Mediavilla, S | 1 |
Chiles, J; Kohn, EC; Moody, E; Moody, TW; Sieczkiewicz, GJ | 1 |
Checkley, D; Curry, B; Dukes, M; Kendrew, J; Middleton, B; Tessier, JJ; Waterton, JC; Wedge, SR | 1 |
Konovalova, NP | 1 |
KOHLER, L; NIEPER, HA | 1 |
NAPALKOV, NP | 1 |
Bruneteau, G; Clement, O; Cuenod, CA; de Bazelaire, C; Frija, G; Frouin, F; Pradel, C; Robert, PH; Siauve, N; Tessier, JL; Wedge, SR | 1 |
Balboa, J; Brenlla, J; Freire-Garabal, M; García-Vallejo, LA; Núñez, MJ; Rey-Méndez, M; Rodrigo, E; Suárez, JM | 1 |
Cherdyntseva, NV; Choinzonov, EL; Kagiya, TV; Kondakova, IV; Tcheredova, VV; Zagrebelnaya, GV | 1 |
Hilgard, P; Peukert, M; Pohl, J | 1 |
Boehme, K; Mohr, U; Steinhoff, D; Weber, H | 1 |
Fujita, T; Hiasa, Y; Iwata, C; Kitahori, Y; Ohshima, M; Yuasa, T | 1 |
Kniazev, DK; Kulagina, TF; Parfenov, IuD; Ryzhova, NI; Savluchinskaia, LA | 1 |
Wahab, A | 1 |
Feinstein, RN; Fry, RJ; Staffeldt, EF | 1 |
Alonso, G; Contreras, A; Sánchez-Pérez, RM | 1 |
Hananouchi, M; Hirao, K; Hirose, M; Tatematsu, M; Tsuda, H | 1 |
Abe, M; Kagiya, VT; Masuoka, M; Nishimoto, S; Sasai, K; Shibamoto, Y; Sugita, T; Zhou, L | 1 |
Abe, M; Ito, T; Kagiya, VT; Nishimoto, S; Sasai, K; Wang, J | 1 |
Abe, M; Hisanaga, Y; Kagiya, T; Nishimoto, S; Sasai, K; Shibamoto, Y; Shimokawa, K; Takahashi, M; Wang, J; Zhou, L | 1 |
Bieser, W; Fiebig, HH; Henss, H; Lohr, GW; Schmid, JR | 1 |
Abe, M; Kagiya, T; Kimura, R; Nishidai, T; Nishimoto, S; Ono, K; Sakano, K; Shibamoto, Y | 1 |
Assandri, A; Bassi, L; Filippeschi, S; Galliani, G; Mistrello, G | 1 |
Brockman, RW | 1 |
Hruban, Z; Morris, HP; Rechcigl, M | 1 |
Vasil'eva, NN | 2 |
Higashi, T; Kashiwagi, K; Tobe, T | 1 |
Tjälve, H | 1 |
Doniach, I | 1 |
Adamson, RH; Hahn, MA | 1 |
Dogen, M; Higashi, T | 1 |
Clayton, JD; Shealy, YF | 1 |
Cohen, HJ | 1 |
Montgomery, JA; Thomas, HJ | 1 |
Florvall, L | 1 |
Pliss, MB; Rubenchik, BL; Shipko, GP | 1 |
1 review(s) available for triazoles and Experimental Neoplasms
Article | Year |
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Biochemical aspects of drug combinations.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Bleomycin; Camptothecin; Cell Division; Cytarabine; Deferoxamine; Diamines; DNA, Neoplasm; Doxorubicin; Drug Therapy, Combination; Leukemia L1210; Macromolecular Substances; Mice; Neoplasms; Neoplasms, Experimental; Nitrosourea Compounds; Purine Nucleotides; Ribonucleotide Reductases; Thioguanine; Triazoles | 1974 |
68 other study(ies) available for triazoles and Experimental Neoplasms
Article | Year |
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Anti-Lung Cancer Activities of 1,2,3-Triazole Curcumin Derivatives via Regulation of the MAPK/NF-κB/STAT3 Signaling Pathways.
Topics: Animals; Antineoplastic Agents; Antioxidants; Biphenyl Compounds; Cell Proliferation; Cell Survival; Cells, Cultured; Curcumin; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Lung Neoplasms; Mitogen-Activated Protein Kinases; Molecular Structure; Neoplasms, Experimental; NF-kappa B; Picrates; STAT3 Transcription Factor; Structure-Activity Relationship; Triazoles; Zebrafish | 2022 |
Design, synthesis, and biological evaluation of 4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridine derivatives as novel dual-PLK1/BRD4 inhibitors.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle Proteins; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Male; Mice; Mice, Inbred NOD; Mice, SCID; Molecular Structure; Neoplasms, Experimental; Polo-Like Kinase 1; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Pteridines; Structure-Activity Relationship; Transcription Factors; Triazoles; Tumor Cells, Cultured | 2020 |
EZH2 inhibits NK cell-mediated antitumor immunity by suppressing CXCL10 expression in an HDAC10-dependent manner.
Topics: Animals; Benzopyrans; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Chemokine CXCL10; Chemokines; Decitabine; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Histone Deacetylases; Humans; Indazoles; Indoles; Killer Cells, Natural; Liver Neoplasms; Male; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Phenols; Pyridones; Sulfones; Triazoles | 2021 |
Discovery of Novel 11-Triazole Substituted Benzofuro[3,2-b]quinolone Derivatives as c-myc G-Quadruplex Specific Stabilizers via Click Chemistry.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Proliferation; Click Chemistry; Dose-Response Relationship, Drug; Down-Regulation; Drug Discovery; Drug Screening Assays, Antitumor; G-Quadruplexes; Humans; Mice; Mice, Nude; Models, Molecular; Molecular Structure; Neoplasms, Experimental; Proto-Oncogene Proteins c-myc; Quinolones; Structure-Activity Relationship; Thermodynamics; Triazoles | 2017 |
Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival.
Topics: AMP-Activated Protein Kinases; Animals; Azepines; Cachexia; Cell Cycle Proteins; Cell Line, Tumor; Epigenesis, Genetic; Forkhead Box Protein O3; Gene Expression Regulation; Humans; Interleukin-6; Male; Metabolic Networks and Pathways; Mice; Muscle, Skeletal; Muscular Atrophy; Neoplasms, Experimental; Nuclear Proteins; Transcription Factors; Triazoles | 2017 |
Thiophenol-formaldehyde triazole causes apoptosis induction in ovary cancer cells and prevents tumor growth formation in mice model.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Formaldehyde; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Structure; Neoplasms, Experimental; Ovarian Neoplasms; Phenols; Structure-Activity Relationship; Sulfhydryl Compounds; Triazoles; Tumor Cells, Cultured | 2019 |
Impact of combination immunochemotherapies on progression of 4NQO-induced murine oral squamous cell carcinoma.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Combined Chemotherapy Protocols; Cancer Vaccines; Cisplatin; Combined Modality Therapy; Female; Immunotherapy; Mice; Mice, Inbred C57BL; Mouth Neoplasms; Neoplasms, Experimental; Squamous Cell Carcinoma of Head and Neck; Treatment Outcome; Triazines; Triazoles; Vaccines, Subunit | 2019 |
Subtype-specific secretomic characterization of pulmonary neuroendocrine tumor cells.
Topics: Animals; Azepines; Basic Helix-Loop-Helix Transcription Factors; Biomarkers, Tumor; Cell Line, Tumor; Cell Survival; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Insulin-Like Growth Factor Binding Protein 5; Lung Neoplasms; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasms, Experimental; Neuroendocrine Tumors; Octamer Transcription Factors; Proteomics; Pyrazoles; Receptor, IGF Type 1; Signal Transduction; Small Cell Lung Carcinoma; Transcription Factors; Triazines; Triazoles | 2019 |
Synthesis and anticancer activity evaluation of a series of [1,2,4]triazolo[1,5-a]pyridinylpyridines in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HCT116 Cells; Humans; MCF-7 Cells; Mice; Models, Molecular; Molecular Structure; Neoplasms, Experimental; Pyridines; Structure-Activity Relationship; Triazoles; Tumor Cells, Cultured | 2013 |
Blockade of A2A receptors potently suppresses the metastasis of CD73+ tumors.
Topics: 5'-Nucleotidase; Adenosine A2 Receptor Antagonists; Animals; Cell Line, Tumor; Cytotoxicity, Immunologic; Flow Cytometry; Granzymes; Humans; Killer Cells, Natural; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Neoplasm Metastasis; Neoplasms, Experimental; Pyrimidines; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Triazoles; Xanthines | 2013 |
Triazole-dithiocarbamate based selective lysine specific demethylase 1 (LSD1) inactivators inhibit gastric cancer cell growth, invasion, and migration.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Histone Demethylases; Humans; Mice; Mice, Inbred BALB C; Models, Molecular; Molecular Dynamics Simulation; Molecular Structure; Neoplasms, Experimental; Stomach Neoplasms; Structure-Activity Relationship; Thiocarbamates; Triazoles | 2013 |
A practical synthesis of [(18) F]FtRGD: an angiogenesis biomarker for PET.
Topics: Animals; Ligands; Mice; Neoplasms, Experimental; Neovascularization, Pathologic; Peptides, Cyclic; Positron-Emission Tomography; Radiopharmaceuticals; Tissue Distribution; Triazoles | 2013 |
RapidCaP, a novel GEM model for metastatic prostate cancer analysis and therapy, reveals myc as a driver of Pten-mutant metastasis.
Topics: Animals; Azepines; Gene Expression Regulation, Neoplastic; Genetic Vectors; HEK293 Cells; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neoplasm Metastasis; Neoplasms, Experimental; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; PTEN Phosphohydrolase; Retroviridae; Triazoles; Tumor Suppressor Protein p53 | 2014 |
Phenobarbital and propiconazole toxicogenomic profiles in mice show major similarities consistent with the key role that constitutive androstane receptor (CAR) activation plays in their mode of action.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Cell Proliferation; Constitutive Androstane Receptor; Female; Fungicides, Industrial; Genes, Reporter; Hepatocytes; Hypnotics and Sedatives; Male; Mice; Neoplasms, Experimental; Organ Size; Phenobarbital; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Toxicogenetics; Triazoles; Weight Gain | 2014 |
Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition.
Topics: Animals; Azepines; Epigenesis, Genetic; Hedgehog Proteins; Kruppel-Like Transcription Factors; Ligands; Mice; Neoplasms, Experimental; Nuclear Proteins; Promoter Regions, Genetic; Signal Transduction; Transcription Factors; Transcription, Genetic; Triazoles; Zinc Finger Protein GLI1; Zinc Finger Protein Gli2 | 2014 |
CEP-33779 antagonizes ATP-binding cassette subfamily B member 1 mediated multidrug resistance by inhibiting its transport function.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Neoplasm; Heterografts; Humans; Mice; Mice, Nude; Molecular Structure; Neoplasms, Experimental; Pyridines; Real-Time Polymerase Chain Reaction; Rhodamine 123; Topotecan; Triazoles | 2014 |
Inhibition of Axl improves the targeted therapy against ALK-mutated neuroblastoma.
Topics: Anaplastic Lymphoma Kinase; Animals; Axl Receptor Tyrosine Kinase; Benzocycloheptenes; Crizotinib; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms, Experimental; Neuroblastoma; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Pyrazoles; Pyridines; Receptor Protein-Tyrosine Kinases; Structure-Activity Relationship; Triazoles; Tumor Cells, Cultured | 2014 |
Discovery of PAT-1102, a novel, potent and orally active histone deacetylase inhibitor with antitumor activity in cancer mouse models.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Apoptosis; HCT116 Cells; HeLa Cells; Histone Deacetylase Inhibitors; Human Umbilical Vein Endothelial Cells; Humans; Hydroxamic Acids; Inhibitory Concentration 50; Male; Mice, Inbred BALB C; Mice, Nude; Mice, SCID; Neoplasms, Experimental; Neovascularization, Pathologic; Triazoles; Vorinostat; Xenograft Model Antitumor Assays | 2015 |
Dipeptidylpeptidase 4 inhibition enhances lymphocyte trafficking, improving both naturally occurring tumor immunity and immunotherapy.
Topics: Adoptive Transfer; Animals; Cell Line, Tumor; Cell Movement; Chemokine CXCL10; Chemokines; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Female; Flow Cytometry; Immunotherapy; Lymphocytes; Male; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Neoplasms, Experimental; Pyrazines; Receptors, CXCR3; Sitagliptin Phosphate; Triazoles | 2015 |
Caffeine promotes anti-tumor immune response during tumor initiation: Involvement of the adenosine A2A receptor.
Topics: Adenosine A2 Receptor Antagonists; Animals; Caffeine; Cell Line, Tumor; Cyclopentanes; Fibrosarcoma; Mice; Mice, Knockout; Neoplasms, Experimental; Receptor, Adenosine A2A; Triazines; Triazoles | 2015 |
Pharmacodynamic and genomic markers associated with response to the XPO1/CRM1 inhibitor selinexor (KPT-330): A report from the pediatric preclinical testing program.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Exportin 1 Protein; Female; Humans; Hydrazines; Inhibitory Concentration 50; Karyopherins; Mice; Mice, SCID; Neoplasms, Experimental; Receptors, Cytoplasmic and Nuclear; Triazoles; Xenograft Model Antitumor Assays | 2016 |
Ginkgo biloba extract EGb 761-mediated inhibition of aromatase for the treatment of hormone-dependent breast cancer.
Topics: Anastrozole; Animals; Antineoplastic Agents, Hormonal; Antineoplastic Agents, Phytogenic; Aromatase; Breast Neoplasms; Cell Proliferation; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Ginkgo biloba; Humans; Mammary Neoplasms, Animal; MCF-7 Cells; Mice; Neoplasms, Experimental; Nitriles; Plant Extracts; RNA, Messenger; Triazoles | 2016 |
Indole-2-carboxylic acid derived mono and bis 1,4-disubstituted 1,2,3-triazoles: Synthesis, characterization and evaluation of anticancer, antibacterial, and DNA-cleavage activities.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Bacillus subtilis; Carboxylic Acids; Cell Proliferation; DNA Cleavage; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Escherichia coli; HEK293 Cells; HeLa Cells; Humans; Indoles; Male; MCF-7 Cells; Mice; Microbial Sensitivity Tests; Molecular Structure; Neoplasms, Experimental; Structure-Activity Relationship; Triazoles | 2016 |
Design and characterization of bivalent BET inhibitors.
Topics: Animals; Antineoplastic Agents; Apoptosis; Azepines; Cell Cycle Proteins; Cell Proliferation; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Design; Humans; Leukemia; Ligands; Mice; Models, Molecular; Molecular Structure; Neoplasms, Experimental; Nuclear Proteins; Small Molecule Libraries; Structure-Activity Relationship; Transcription Factors; Triazoles | 2016 |
An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED.
Topics: Allosteric Regulation; Animals; Antineoplastic Agents; Binding Sites; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Histones; Humans; Lysine; Mice; Mice, Inbred BALB C; Mice, Nude; Models, Molecular; Molecular Structure; Neoplasms, Experimental; Polycomb Repressive Complex 2; Structure-Activity Relationship; Sulfones; Triazoles; Tumor Cells, Cultured | 2017 |
The antiangiogenic agent ZD4190 prevents tumour outgrowth in a model of minimal residual carcinoma in deep tissues.
Topics: Angiogenesis Inhibitors; Animals; Disease Models, Animal; Female; Mice; Mice, Inbred C57BL; Neoplasm, Residual; Neoplasms, Experimental; Quinazolines; Triazoles; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2009 |
Novel triazole ribonucleoside down-regulates heat shock protein 27 and induces potent anticancer activity on drug-resistant pancreatic cancer.
Topics: Animals; Apoptosis; Cell Line, Tumor; Down-Regulation; Drug Resistance, Neoplasm; HSP27 Heat-Shock Proteins; Humans; Mice; Neoplasms, Experimental; Pancreatic Neoplasms; Ribonucleosides; Transplantation, Heterologous; Treatment Outcome; Triazoles | 2009 |
Ron kinase transphosphorylation sustains MET oncogene addiction.
Topics: Animals; Blotting, Western; Cell Line, Tumor; Female; Gene Silencing; Humans; Mice; Mice, Nude; Neoplasms, Experimental; Oncogenes; Phosphorylation; Proto-Oncogene Proteins c-met; Pyrazoles; Pyridazines; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Signal Transduction; Transcriptional Activation; Transplantation, Heterologous; Triazoles | 2011 |
Multifaceted intervention by the Hsp90 inhibitor ganetespib (STA-9090) in cancer cells with activated JAK/STAT signaling.
Topics: Animals; Cell Division; Genes, cdc; HSP90 Heat-Shock Proteins; Janus Kinase 2; Mice; Neoplasms, Experimental; Signal Transduction; STAT Transcription Factors; Triazoles; Tumor Cells, Cultured | 2011 |
Preclinical evaluation and validation of [18F]HX4, a promising hypoxia marker for PET imaging.
Topics: Animals; Biomarkers; Cell Hypoxia; Fluorine Radioisotopes; Imidazoles; Male; Neoplasms, Experimental; Nitroimidazoles; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Triazoles | 2011 |
Initial testing (stage 1) of ganetespib, an Hsp90 inhibitor, by the Pediatric Preclinical Testing Program.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; HSP90 Heat-Shock Proteins; Humans; Mice; Mice, SCID; Neoplasms, Experimental; Triazoles; Xenograft Model Antitumor Assays | 2013 |
Maraviroc, a CCR5 antagonist, prevents development of hepatocellular carcinoma in a mouse model.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; CCR5 Receptor Antagonists; Cell Proliferation; Cyclohexanes; Humans; Liver Cirrhosis; MAP Kinase Signaling System; Maraviroc; Mice; Neoplasms, Experimental; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Receptors, CCR5; Triazoles | 2013 |
CAI inhibits the growth of small cell lung cancer cells.
Topics: Animals; Antineoplastic Agents; Carcinoma, Small Cell; Cell Division; Dose-Response Relationship, Drug; Humans; Lung Neoplasms; Mice; Mice, Nude; Neoplasms, Experimental; Neovascularization, Pathologic; Transplantation, Heterologous; Triazoles; Tumor Cells, Cultured | 2003 |
Dynamic contrast-enhanced MRI of vascular changes induced by the VEGF-signalling inhibitor ZD4190 in human tumour xenografts.
Topics: Animals; Contrast Media; Female; Gadolinium DTPA; Humans; Magnetic Resonance Imaging; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Quinazolines; Transplantation, Heterologous; Triazoles; Vascular Endothelial Growth Factor A | 2003 |
Ultralow doses of various drugs in chemotherapy of experimental tumors.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Indazoles; Leukemia P388; Lung Neoplasms; Melanoma; Mice; Mitomycin; Neoplasm Metastasis; Neoplasms, Experimental; Triazoles; Xenograft Model Antitumor Assays | 2003 |
[The development and evaluation of fungistatic compounds in the treatment of cancer. 2].
Topics: Antifungal Agents; Antineoplastic Agents; Humans; Neoplasms; Neoplasms, Experimental; Triazoles | 1963 |
ON SOME NEW ASPECTS OF EXPERIMENTAL CARCINOGENESIS THYROID GLAND.
Topics: Carcinogenesis; Methylthiouracil; Neoplasms; Neoplasms, Experimental; Rats; Research; Thyroid Neoplasms; Triazoles | 1963 |
Reduced capillary perfusion and permeability in human tumour xenografts treated with the VEGF signalling inhibitor ZD4190: an in vivo assessment using dynamic MR imaging and macromolecular contrast media.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Capillary Permeability; Cell Line, Tumor; Contrast Media; Magnetic Resonance Angiography; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Neovascularization, Pathologic; Quinazolines; Triazoles; Vascular Endothelial Growth Factor A | 2003 |
Effects of nefazodone on the development of experimentally induced tumors in stressed rodents.
Topics: Animals; Antidepressive Agents, Second-Generation; Carcinoma 256, Walker; Male; Mammary Tumor Virus, Mouse; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Piperazines; Rats; Rats, Sprague-Dawley; Retroviridae Infections; Stress, Psychological; Triazoles; Tumor Cells, Cultured; Tumor Virus Infections | 2004 |
Production of nitric oxide by hypoxic radiosensitizer sanazole.
Topics: Animals; Cell Hypoxia; Lymphoma; Mastocytoma; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Nitric Oxide; Oxyhemoglobins; Radiation-Sensitizing Agents; Triazoles | 2004 |
alpha-/beta-Triglycidyl-urazol (TGU, NSC 332488, I.N.N.: ANAXIRONE): a new chemotherapeutic agent.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Drug Evaluation; Drug Evaluation, Preclinical; Humans; Kinetics; Metabolic Clearance Rate; Mice; Neoplasms; Neoplasms, Experimental; Rats; Triazines; Triazoles | 1984 |
Evaluation of amitrole (aminotriazole) for potential carcinogenicity in orally dosed rats, mice, and golden hamsters.
Topics: Amitrole; Animals; Carcinogens; Cricetinae; Female; Iodine Radioisotopes; Liver Neoplasms; Male; Mesocricetus; Mice; Neoplasms, Experimental; Organ Size; Pituitary Neoplasms; Rats; Rats, Inbred Strains; Thyroid Gland; Thyroid Neoplasms; Triazoles | 1983 |
Promoting effects of 3-amino-1,2,4-triazole on the development of thyroid tumors in rats treated with N-bis(2-hydroxypropyl)nitrosamine.
Topics: Amitrole; Animals; Carcinogens; Drug Synergism; Male; Neoplasms, Experimental; Nitrosamines; Organ Size; Rats; Rats, Inbred Strains; Thyroid Gland; Thyroid Neoplasms; Triazoles | 1982 |
[Study of cancerogenic effect of 4-amino-1,2,4-triazole in chronic experiments].
Topics: Administration, Oral; Animals; Female; Incidence; Injections, Subcutaneous; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Neoplasms, Experimental; Rats; Rats, Wistar; Sex Factors; Triazoles | 1993 |
Clinical development plan: (+)-vorozole.
Topics: Animals; Anticarcinogenic Agents; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Drug Approval; Enzyme Inhibitors; Estradiol; Female; Humans; Male; Neoplasms, Experimental; Rats; Research Design; Triazoles | 1996 |
Substituted thiatriazoles as possible anticancer compounds.
Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line; Humans; Neoplasms, Experimental; Triazoles | 1979 |
Carcinogenic and antitumor effects of aminotriazole on acatalasemic and normal catalase mice.
Topics: Amitrole; Animals; Antineoplastic Agents; Carcinogens; Catalase; Female; Liver Neoplasms; Lymphoma; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Neoplasms, Radiation-Induced; Triazoles | 1978 |
Halomethyl-1,2,3-triazole derivatives: a new type of alkylating agent active in mouse transplantable tumors.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Cells, Cultured; DNA, Neoplasm; Drug Stability; Female; Mice; Mice, Inbred ICR; Neoplasm Transplantation; Neoplasms, Experimental; Time Factors; Transplantation, Homologous; Triazoles | 1978 |
Tumorigenic effect of 3-amino-1H-1,2,4-triazole on rat thyroid.
Topics: Amitrole; Animals; Cystadenoma; Female; Goiter; Hyperplasia; Neoplasms, Experimental; Rats; Thyroid Gland; Thyroid Neoplasms; Transplantation, Autologous; Triazoles | 1976 |
Metabolic rate modification of nitrotriazole radiosensitizers by sulfur substitution of side chain.
Topics: Animals; Cell Hypoxia; Combined Modality Therapy; Female; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Neoplasms, Experimental; Radiation-Sensitizing Agents; Triazoles; Tumor Cells, Cultured | 1992 |
Fluorine modification of nitroazole radiosensitizers for the enhancement of sensitizing activity with lowering toxicity: a pharmacokinetic characterization.
Topics: Animals; Brain; Combined Modality Therapy; Female; Lethal Dose 50; Mice; Mice, Inbred C3H; Mice, Inbred ICR; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents; Triazoles | 1992 |
Characteristics of fluorinated nitroazoles as hypoxic cell radiosensitizers.
Topics: Animals; Cell Survival; Combined Modality Therapy; Hydrocarbons, Fluorinated; In Vitro Techniques; Lethal Dose 50; Mice; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Triazoles | 1989 |
Colony assay with human tumor xenografts, murine tumors and human bone marrow. Potential for anticancer drug development.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Cell Division; Cell Survival; Cells, Cultured; Colony-Forming Units Assay; Dose-Response Relationship, Drug; In Vitro Techniques; Mice; Mice, Nude; Neoplasms, Experimental; Ribavirin; Transplantation, Heterologous; Triazoles | 1987 |
Radiosensitization in vitro and in vivo by 3-nitrotriazoles.
Topics: Animals; Combined Modality Therapy; Cricetinae; Female; In Vitro Techniques; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Neoplasm Transplantation; Neoplasms, Experimental; Nitro Compounds; Nitroimidazoles; Radiation-Sensitizing Agents; Triazoles | 1986 |
Immunological profile of DL111-IT, a new immunosuppressant agent.
Topics: Animals; Antibody Formation; Dose-Response Relationship, Drug; Hypersensitivity, Delayed; Immunosuppressive Agents; Inflammation; Lymphoma; Male; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Triazoles | 1985 |
The roles of synthesis and degradation in the regulation of catalase levels in the neoplastic tissues.
Topics: Animals; Carcinoma, Hepatocellular; Catalase; Cell Membrane Permeability; Hydrogen; Kinetics; Liver; Liver Neoplasms; Mice; Microscopy, Electron; Neoplasms, Experimental; Peroxidases; Triazoles | 1969 |
[Morphologic characteristics of spontaneous tumors and leukoses in 1st generation C47B1XCBA hybrid mice].
Topics: Adenoma; Animals; Carcinogens; Carcinoma, Hepatocellular; Leukemia, Experimental; Liver; Liver Neoplasms; Lung; Lung Neoplasms; Lymphoma, Large B-Cell, Diffuse; Mice; Neoplasms, Experimental; Triazoles | 1969 |
Studies on rat liver catalase. V. Incorporation of 14 C-leucine into catalase by isolated rat liver ribosomes.
Topics: Acetamides; Animals; Carbon Isotopes; Carcinoma, Hepatocellular; Catalase; Cell-Free System; Cycloheximide; Dactinomycin; Depression, Chemical; In Vitro Techniques; Leucine; Liver; Liver Neoplasms; Male; Neoplasms, Experimental; Nucleotides; Puromycin; Rats; Ribonucleases; Ribosomes; Triazoles | 1971 |
X-accumulation of labelled aminotriazole in some transplanted tumours in mice.
Topics: Animals; Autoradiography; Carbon Radioisotopes; Carcinoma; Fibrosarcoma; Intestines; Kidney; Liver; Lymphoma; Mammary Neoplasms, Experimental; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Spleen; Time Factors; Transplantation, Homologous; Triazoles | 1974 |
Carcinogenic effect of 100, 250 and 500 rad X-rays on the rat thyroid gland.
Topics: Adenocarcinoma; Adenoma; Animals; Male; Neoplasms, Experimental; Neoplasms, Radiation-Induced; Radiation Dosage; Rats; Rats, Inbred Strains; Thyroid Neoplasms; Thyrotropin; Thyroxine; Triazoles | 1974 |
Pharmacology of 3,5-diamino-1,24-triazole (guanazole). 1. Antitumor activity of guanazole.
Topics: Amines; Animals; Antineoplastic Agents; Carcinoma 256, Walker; Cyclophosphamide; Cytarabine; Depression, Chemical; Female; Hydroxyurea; In Vitro Techniques; Leukemia L1210; Leukemia, Experimental; Lymphoma, Large B-Cell, Diffuse; Male; Mast-Cell Sarcoma; Methotrexate; Mice; Neoplasms, Experimental; Nitrosourea Compounds; Plasmacytoma; Structure-Activity Relationship; Triazoles | 1972 |
[Differences among liver, kidney and erythrocyte catalasses of the rat].
Topics: Allyl Compounds; Animals; Antigen-Antibody Reactions; Catalase; Electrophoresis; Enzyme Activation; Erythrocytes; Kidney; Kinetics; Liver; Male; Neoplasms, Experimental; Rats; Triazoles | 1972 |
Carbocyclic analog of purine ribonucleosides with antileukemic activity.
Topics: Aza Compounds; Carcinoma, Squamous Cell; Cells, Cultured; Humans; Leukemia; Neoplasms, Experimental; Purines; Ribonucleosides; Triazoles | 1973 |
Peroxide detoxification affecting the production of immunoglobulin by mouse myeloma tumor cells in vitro.
Topics: Animals; Catalase; Cells, Cultured; Glucose; Immunoglobulins; Leucine; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Peroxidases; Peroxides; Plasmacytoma; Stimulation, Chemical; Triazoles; Tritium | 1973 |
Nucleosides of 8-azapurines (v-triazolo(4,5-d) pyrimidines).
Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Cells, Cultured; Deamination; Humans; Magnetic Resonance Spectroscopy; Neoplasms, Experimental; Nucleosides; Optical Rotation; Pyrimidines; Stereoisomerism; Structure-Activity Relationship; Triazoles | 1972 |
Some antitumor agents derived from benzaldehyde nitrogen mustards.
Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Chemical Phenomena; Chemistry; Hydrazines; Leukemia L1210; Mice; Neoplasms, Experimental; Nitrogen Mustard Compounds; Rats; Triazoles | 1970 |
[A comparative evaluation of the toxic and possible carcinogenic effect of benzotriazol and phenidon].
Topics: Animals; Carcinogens; Chemical and Drug Induced Liver Injury; Female; Fibroma; Leukemia, Experimental; Lung Diseases; Lung Neoplasms; Male; Mesentery; Mice; Neoplasms, Experimental; Rats; Sarcoma, Experimental; Splenic Diseases; Triazoles | 1970 |
[Water-soluble and lipid-bound catalase in the liver and malignant tumors of rats].
Topics: Animals; Carcinoma; Catalase; Chemical Phenomena; Chemistry, Physical; Depression, Chemical; Lipid Metabolism; Liver; Neoplasms, Experimental; Rats; Sarcoma, Experimental; Solubility; Triazoles | 1966 |