Carcinomatous Meningitis

Synonym
Leptomeningeal Carcinomatosis
Carcinomatous Meningitis

Excerpt	Reference
"Leptomeningeal carcinomatosis is an uncommon manifestation of non-central nervous system (CNS) metastatic disease."	( Carra, BJ; Clemenshaw, MN, 2015)
"Leptomeningeal carcinomatosis is a fatal manifestation of metastatic breast cancer."	( Bae, SB; Kim, HJ; Kim, K; Lee, KT; Lee, N; Lee, SC; Park, HS; Park, WY; Won, JH, 2016)
"Leptomeningeal carcinomatosis is a condition in which metastatic cancer cells infiltrate the meninges of the brain and spinal cord, progressing to also involve the cerebrospinal fluid."	( Boursiquot, R; Hanif, S; Jain, M; Krol, D; Rojas, J, 2016)
"Leptomeningeal carcinomatosis is a rare type of metastatic tumors of the central nervous system."	( Kong, J; Li, J; Wan, J; Wu, X; Xiao, J; Xu, H; Yang, B; Yu, L, 2016)
"Leptomeningeal carcinomatosis is a relatively rare metastatic form of non-small cell lung cancer, which can impact prognosis."	( Hosomi, Y; Kashima, J; Miwa, M; Okuma, Y, 2017)
"Leptomeningeal carcinomatosis is a rare but serious complication of solid tumors such as melanoma, breast and lung cancer, as well as gastrointestinal carcinomas."	( Höblinger, A; Kröber, S; Streetz, K; Tschirner, F; Weber, S, 2017)
"Leptomeningeal carcinomatosis is a devastating sequelae of metastatic cancer."	( Beran, RG; Bonura, A; Brooks, CA, 2021)

Excerpt	Reference
"Carcinomatous meningitis has a rapidly progressive course with very poor prognosis."	( Kamimura, R; Kanemoto, Y; Kashima, S; Koyama, T; Miyamoto, K; Miyanaga, H; Oishi, T; Sakahira, H; Soyama, H; Takahashi, H; Watanabe, A, 2019)

Excerpt	Reference
"The prognosis of patients with carcinomatous meningitis from non-small-cell lung cancer (NSCLC) remains poor, and the available treatment options for the lung cancer do not relieve the severe symptoms of this sequela."	( Chikaishi, Y; Inoue, M; Nose, N; So, T; Sugio, K; Yasumoto, K, 2009)
"The treatment of carcinomatous meningitis in patients with non-small cell lung cancer is unsatisfactory with a median survival ranging from 4 to 6 weeks without treatment."	( Fukuda, A; Sonoda, T; Takenaka, T; Yamagata, M, 2011)
"Reports on the treatment result of leptomeningeal carcinomatosis (LMC) from a single primary cancer are rare and mixed treatment modalities make it even more difficult to interpret the results properly."	( Gwak, HS; Han, JY; Joo, J; Kim, HT; Kim, S; Lee, JS; Lee, SH; Shin, SH; Yoo, H, 2013)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	5 (2.44)	23.3326
1990's	0 (0.00)	12.5806
2000's	11 (5.37)	18.1394
2010's	139 (67.80)	28.8240
2020's	50 (24.39)	9.53

Drug	Relationship Strength	Studies	Trials
adenine	low	2	0
carbamates	low	1	0
choline	low	2	0
citric acid, anhydrous	low	1	0
creatine	low	1	0
lactic acid	low	1	0
inositol	low	1	0
niacinamide	low	1	0
phenytoin	low	1	0
celecoxib	low	1	0
fluorouracil	low	1	0
ifosfamide	low	2	0
ketamine	low	1	0
letrozole	low	3	0
phenobarbital	low	1	0
rizatriptan	low	1	0
temozolomide	low	5	0
thiotepa	low	2	0
hydrocortisone acetate	low	1	0
prednisone	low	1	0
alanine	low	1	0
methionine	low	1	0
cytarabine	medium	21	4
methylprednisolone	low	3	0
pyrroles	low	1	0
quinazolines	medium	34	1
alpha-aminopyridine	low	2	0
deoxycytidine	low	2	0
gadolinium	low	5	0
camptothecin	low	3	0
paclitaxel	low	5	0
etoposide	medium	5	1
idarubicin	low	1	0
aromasil	low	1	0
topotecan	low	2	0
gemcitabine	low	2	0
irinotecan	low	2	0
3-iodobenzylguanidine	low	1	0
capecitabine	low	2	0
triazoles	low	3	0
fluorodeoxyglucose f18	low	9	0
gefitinib	low	15	0
methotrexate	medium	36	5
docetaxel anhydrous	low	1	0
erlotinib hydrochloride	low	30	0
lapatinib	low	5	0
sorafenib	low	1	0
n,n-dimethyl-n-(18f)fluoromethyl-2-hydroxyethylammonium	low	2	0
carboplatin	low	4	0
bromochloroacetic acid	low	1	0
sphingosine	low	1	0
isotretinoin	low	1	0
sphingosine 1-phosphate	low	1	0
su 11248	low	1	0
astatine	low	1	0
gadolinium dtpa	low	2	0
bibw 2992	medium	11	1
binimetinib	low	1	0
er-086526	low	1	0
pf 00299804	low	2	0
crizotinib	low	8	0
trametinib	low	2	0
icotinib	low	2	0
pci 32765	low	2	0
poziotinib	low	1	0
plx4032	low	1	0
piperidines	low	10	0
dabrafenib	low	2	0
abemaciclib	low	1	0
alectinib	low	8	0
encorafenib	low	1	0
ceritinib	low	2	0
osimertinib	medium	28	2
pf-06463922	low	1	0
gallium ga 68 dotatate	low	1	0
68ga-dotanoc	low	1	0
levoleucovorin	medium	2	1
guanine	low	2	0
dacarbazine	low	5	0
ganciclovir	low	1	0
pemetrexed	medium	15	1
eye	low	1	0
pyrimidinones	low	2	0

Protein Targets (1,358)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
dopamine D1 receptor	2	0	0	2
thioredoxin reductase	12	0	0	12
GLS protein	4	0	0	4
Thrombopoietin	3	0	0	3
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	6	0	0	6
cytochrome P450 2D6 isoform 1	1	0	0	1
cytochrome P450 2C19 precursor	3	0	0	3
ras-related protein Rab-9A	3	0	0	3
histone acetyltransferase KAT2A isoform 1	6	0	0	6
lethal factor (plasmid)	2	0	0	2
POU domain, class 2, transcription factor 1	0	0	0	1
Spike glycoprotein	11	0	1	12
ATP-dependent phosphofructokinase	9	0	0	9
PPM1D protein	21	0	0	21
cytochrome P450 family 3 subfamily A polypeptide 4	20	0	0	20
cytochrome P450 2D6	14	0	0	14
Bone morphogenetic protein receptor type-1B	0	0	19	19
Cell division cycle 7-related protein kinase	0	0	15	15
Serine/threonine-protein kinase PLK4	0	2	19	21
ATP-dependent RNA helicase DDX3X	0	0	19	19
Pyridoxal kinase	0	0	19	19
Citron Rho-interacting kinase	0	0	19	19
Serine/threonine-protein kinase Chk1	0	1	20	21
Aurora kinase A	0	2	19	21
Cyclin-G-associated kinase	0	2	19	21
Ephrin type-B receptor 6	0	0	19	19
Peroxisomal acyl-coenzyme A oxidase 3	0	0	19	19
Receptor-interacting serine/threonine-protein kinase 2	0	2	19	21
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	19	19
Dynamin-like 120 kDa protein, mitochondrial	0	0	19	19
Cyclin-T1	0	2	0	2
Eukaryotic translation initiation factor 5B	0	0	13	13
Rho-associated protein kinase 2	0	1	19	20
Serine/threonine-protein kinase ULK1	0	0	19	19
Serine/threonine-protein kinase/endoribonuclease IRE1	0	1	19	20
Ribosomal protein S6 kinase alpha-5	0	0	19	19
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	19	19
Ribosomal protein S6 kinase alpha-4	0	0	19	19
Serine/threonine-protein kinase 16	0	0	19	19
Cyclin-K	0	1	0	1
Cyclin-dependent kinase-like 5	0	0	16	16
Serine/threonine-protein kinase 10	0	0	19	19
Serine/threonine-protein kinase D3	0	0	19	19
Structural maintenance of chromosomes protein 2	0	0	19	19
Mitogen-activated protein kinase kinase kinase 6	0	0	19	19
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	19	19
Serine/threonine-protein kinase LATS1	0	0	19	19
Serine/threonine-protein kinase PAK 4	0	2	19	21
Tyrosine-protein kinase ABL1	0	10	21	31
Epidermal growth factor receptor	0	24	25	50
Interferon beta	27	0	0	27
High affinity nerve growth factor receptor	0	4	19	23
Guanine nucleotide-binding protein G(i) subunit alpha-2	0	0	18	18
ADP/ATP translocase 2	0	0	19	19
Protein kinase C beta type	0	0	19	19
Insulin receptor	0	8	19	27
Tyrosine-protein kinase Lck	0	6	19	25
Tyrosine-protein kinase Fyn	0	3	19	22
Cyclin-dependent kinase 1	0	4	19	23
Glycogen phosphorylase, liver form	0	0	19	19
Tyrosine-protein kinase Fes/Fps	0	2	19	21
Tyrosine-protein kinase Yes	0	1	19	20
Tyrosine-protein kinase Lyn	0	2	19	21
Proto-oncogene tyrosine-protein kinase receptor Ret	0	9	19	28
Insulin-like growth factor 1 receptor	0	6	19	25
Signal recognition particle receptor subunit alpha	0	0	17	17
Cytochrome c1, heme protein, mitochondrial	0	0	19	19
Hepatocyte growth factor receptor	0	7	18	25
Tyrosine-protein kinase HCK	0	4	19	23
Platelet-derived growth factor receptor beta	0	8	19	27
Replicase polyprotein 1ab	0	3	1	4
Serine/threonine-protein kinase A-Raf	0	3	19	22
Glycogen phosphorylase, brain form	0	0	19	19
Breakpoint cluster region protein	0	1	20	21
Serine/threonine-protein kinase pim-1	0	1	19	20
Fibroblast growth factor receptor 1	0	5	19	24
DNA topoisomerase 2-alpha	0	3	19	27
Cyclin-dependent kinase 4	0	4	19	24
ADP/ATP translocase 3	0	0	19	19
Inosine-5'-monophosphate dehydrogenase 2	0	0	17	17
Proto-oncogene tyrosine-protein kinase Src	0	10	19	29
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	18	18
G2/mitotic-specific cyclin-B1	0	3	0	3
Serine/threonine-protein kinase B-raf	0	7	22	31
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	19	19
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	0	19	19
Tyrosine-protein kinase Fer	0	2	19	21
Protein kinase C alpha type	0	0	19	19
cAMP-dependent protein kinase catalytic subunit alpha	0	0	19	19
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	19	19
Casein kinase II subunit alpha'	0	0	18	18
Cyclin-A2	0	1	0	1
Ras-related protein Rab-6A	0	0	19	19
Ephrin type-A receptor 1	0	0	17	17
Multifunctional protein ADE2	0	0	19	19
cAMP-dependent protein kinase catalytic subunit gamma	0	0	16	16
cAMP-dependent protein kinase catalytic subunit beta	0	0	19	19
Ferrochelatase, mitochondrial	0	0	20	20
Ribosomal protein S6 kinase beta-1	0	1	19	20
Tyrosine-protein kinase JAK1	0	4	19	23
G1/S-specific cyclin-D1	0	3	0	3
G1/S-specific cyclin-E1	0	4	0	4
Cyclin-dependent kinase 2	0	7	20	27
Beta-adrenergic receptor kinase 1	0	0	19	19
Probable ATP-dependent RNA helicase DDX6	0	0	19	19
Mitogen-activated protein kinase 3	0	1	19	20
MAP/microtubule affinity-regulating kinase 3	0	0	19	19
Deoxycytidine kinase	0	0	19	22
Mitogen-activated protein kinase 1	0	2	19	21
Ephrin type-A receptor 2	0	3	19	22
Ephrin type-B receptor 2	0	1	19	20
Non-receptor tyrosine-protein kinase TYK2	0	1	19	20
G1/S-specific cyclin-D3	0	2	0	2
Wee1-like protein kinase	0	0	19	19
Heme oxygenase 2	0	0	19	19
S-adenosylmethionine synthase isoform type-2	0	0	19	19
DnaJ homolog subfamily A member 1	0	0	19	19
RAC-alpha serine/threonine-protein kinase	0	1	19	20
RAC-beta serine/threonine-protein kinase	0	1	19	20
Dual specificity protein kinase TTK	0	0	13	13
DNA replication licensing factor MCM4	0	0	19	19
Dual specificity mitogen-activated protein kinase kinase 2	0	4	19	23
Receptor-type tyrosine-protein kinase FLT3	0	7	19	27
Bone morphogenetic protein receptor type-1A	0	0	19	19
Activin receptor type-1B	0	0	19	19
TGF-beta receptor type-1	0	1	19	20
TGF-beta receptor type-2	0	0	18	18
Tyrosine-protein kinase CSK	0	1	19	20
Glycine--tRNA ligase	0	0	19	19
Protein kinase C iota type	0	0	19	19
Exosome RNA helicase MTR4	0	0	19	19
Tyrosine-protein kinase Tec	0	1	19	20
Tyrosine-protein kinase ABL2	0	1	19	20
Tyrosine-protein kinase FRK	0	3	19	22
Tyrosine-protein kinase SYK	0	2	19	21
26S proteasome regulatory subunit 6B	0	0	19	19
Mitogen-activated protein kinase 8	0	0	19	19
Mitogen-activated protein kinase 9	0	0	19	19
Dual specificity mitogen-activated protein kinase kinase 3	0	0	19	19
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	17	17
Casein kinase I isoform alpha	0	3	18	21
Casein kinase I isoform delta	0	0	19	19
MAP kinase-activated protein kinase 2	0	0	19	19
Elongation factor Tu, mitochondrial	0	0	19	19
Choline-phosphate cytidylyltransferase A	0	0	13	13
Casein kinase I isoform epsilon	0	0	19	19
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	19	19
Dual specificity protein kinase CLK1	0	0	19	19
Dual specificity protein kinase CLK3	0	0	15	15
Glycogen synthase kinase-3 alpha	0	0	19	19
Glycogen synthase kinase-3 beta	0	2	19	21
Cyclin-dependent kinase 7	0	3	19	22
Cyclin-dependent kinase 9	0	2	19	21
Ras-related protein Rab-27A	0	0	19	19
Interleukin-1 receptor-associated kinase 1	0	0	19	19
Ribosomal protein S6 kinase alpha-3	0	1	19	20
Cyclin-H	0	2	0	2
CDK-activating kinase assembly factor MAT1	0	2	0	2
Serine/threonine-protein kinase Nek2	0	1	19	20
Serine/threonine-protein kinase Nek3	0	0	19	19
Dual specificity mitogen-activated protein kinase kinase 6	0	0	19	19
LIM domain kinase 1	0	0	19	19
LIM domain kinase 2	0	0	19	19
Tyrosine--tRNA ligase, cytoplasmic	0	0	19	19
5'-AMP-activated protein kinase subunit gamma-1	0	0	19	19
Ephrin type-B receptor 3	0	0	19	19
Ephrin type-A receptor 5	0	0	19	19
Ephrin type-B receptor 4	0	4	19	23
Ephrin type-A receptor 4	0	0	19	19
Adenylate kinase 2, mitochondrial	0	0	19	19
Adenosine kinase	0	0	19	19
Ras-related protein Rab-10	0	0	18	18
Actin-related protein 3	0	0	19	19
Actin-related protein 2	0	0	18	18
GTP-binding nuclear protein Ran	0	0	19	19
Casein kinase I isoform gamma-2	0	0	17	17
Cyclin-dependent kinase 6	0	3	19	23
Cyclin-dependent-like kinase 5	0	1	19	20
Cyclin-dependent kinase 16	0	0	19	19
Cyclin-dependent kinase 17	0	0	19	19
ATP-dependent 6-phosphofructokinase, platelet type	0	0	18	18
Dual specificity mitogen-activated protein kinase kinase 1	0	4	19	23
DNA topoisomerase 2-beta	0	2	20	29
Protein kinase C theta type	0	0	18	18
Activin receptor type-1	0	0	19	19
Macrophage-stimulating protein receptor	0	1	19	20
Focal adhesion kinase 1	0	3	19	22
Protein kinase C zeta type	0	0	12	12
Protein kinase C delta type	0	0	19	19
Tyrosine-protein kinase BTK	0	4	20	24
Activated CDC42 kinase 1	0	2	19	21
Epithelial discoidin domain-containing receptor 1	0	0	19	19
Potassium voltage-gated channel subfamily H member 2	0	10	0	10
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	19	19
Serine/threonine-protein kinase 4	0	0	19	19
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	1	19	20
Dual specificity mitogen-activated protein kinase kinase 5	0	0	19	19
Mitogen-activated protein kinase 7	0	0	19	19
Serine/threonine-protein kinase PAK 2	0	1	18	19
Serine/threonine-protein kinase 3	0	0	19	19
Mitogen-activated protein kinase kinase kinase 1	0	0	19	19
Rho-associated protein kinase 1	0	0	19	19
Non-receptor tyrosine-protein kinase TNK1	0	0	19	19
Serine/threonine-protein kinase ATR	0	0	10	10
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	19	19
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	19	19
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	1	19	20
Activin receptor type-2B	0	0	19	19
Bone morphogenetic protein receptor type-2	0	0	19	19
Protein-tyrosine kinase 6	0	1	19	20
cGMP-dependent protein kinase 1	0	0	19	19
Cyclin-dependent kinase 13	0	0	19	19
Calcium/calmodulin-dependent protein kinase type 1	0	1	6	7
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	19	19
Protein-tyrosine kinase 2-beta	0	2	19	21
Maternal embryonic leucine zipper kinase	0	0	19	19
Structural maintenance of chromosomes protein 1A	0	0	17	17
Chromodomain-helicase-DNA-binding protein 4	0	0	19	19
Cyclin-dependent kinase 5 activator 1	0	1	0	1
Delta(24)-sterol reductase	0	0	19	19
Ribosomal protein S6 kinase alpha-1	0	2	19	21
Dual specificity testis-specific protein kinase 1	0	0	14	14
Myosin light chain kinase, smooth muscle	0	0	19	19
Mitogen-activated protein kinase 11	0	0	19	19
Serine/threonine-protein kinase STK11	0	0	19	19
Serine/threonine-protein kinase N1	0	0	19	19
Serine/threonine-protein kinase N2	0	1	19	20
Mitogen-activated protein kinase 14	0	5	19	24
Calcium/calmodulin-dependent protein kinase type IV	0	0	19	19
Mitogen-activated protein kinase kinase kinase 11	0	0	19	19
MAP kinase-activated protein kinase 3	0	0	12	12
Discoidin domain-containing receptor 2	0	1	19	20
AP2-associated protein kinase 1	0	1	19	20
Myosin light chain kinase 3	0	0	19	19
Uncharacterized aarF domain-containing protein kinase 5	0	0	15	15
Putative heat shock protein HSP 90-beta 2	0	0	18	18
Rab-like protein 3	0	0	17	17
Serine/threonine-protein kinase MRCK alpha	0	0	19	19
Serine/threonine-protein kinase MRCK gamma	0	0	18	18
Serine/threonine-protein kinase N3	0	0	16	16
Serine/threonine-protein kinase ULK3	0	0	19	19
Uncharacterized protein FLJ45252	0	0	19	19
Acyl-CoA dehydrogenase family member 11	0	0	17	17
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	18	18
Serine/threonine-protein kinase MARK2	0	0	19	19
Serine/threonine-protein kinase TAO1	0	0	19	19
STE20-related kinase adapter protein alpha	0	0	19	19
Myosin-14	0	0	18	18
AarF domain-containing protein kinase 1	0	0	19	19
ATP-dependent RNA helicase DDX42	0	0	17	17
Homeodomain-interacting protein kinase 1	0	2	6	8
Mitogen-activated protein kinase kinase kinase kinase 3	0	1	19	20
MAP kinase-activated protein kinase 5	0	0	19	19
Atypical kinase COQ8A, mitochondrial	0	0	19	19
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	19	19
Mitogen-activated protein kinase 15	0	0	19	19
Serine/threonine-protein kinase Nek9	0	0	19	19
ATP-dependent RNA helicase DDX1	0	0	18	18
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	19	19
Aurora kinase B	0	1	18	19
MAP/microtubule affinity-regulating kinase 4	0	0	19	19
Serine/threonine-protein kinase Nek1	0	0	19	19
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	19	19
EKC/KEOPS complex subunit TP53RK	0	0	19	19
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	19	19
Mitogen-activated protein kinase kinase kinase 5	0	0	19	19
Mitogen-activated protein kinase kinase kinase 3	0	0	19	19
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	19	19
Nucleolar GTP-binding protein 1	0	0	19	19
Serine/threonine-protein kinase D2	0	0	19	19
NUAK family SNF1-like kinase 2	0	0	19	19
RNA cytidine acetyltransferase	0	0	19	19
Serine/threonine-protein kinase SIK2	0	0	19	19
STE20-like serine/threonine-protein kinase	0	0	19	19
Serine/threonine-protein kinase TAO3	0	0	19	19
dCTP pyrophosphatase 1	0	0	19	19
Dual specificity protein kinase CLK4	0	0	16	16
Casein kinase I isoform gamma-1	0	0	19	19
Phenylalanine--tRNA ligase beta subunit	0	0	19	19
Isoleucine--tRNA ligase, mitochondrial	0	0	11	11
BMP-2-inducible protein kinase	0	0	19	19
Midasin	0	0	19	19
Interleukin-1 receptor-associated kinase 4	0	0	19	19
Mitogen-activated protein kinase kinase kinase 20	0	1	19	20
Cyclin-dependent kinase 12	0	0	19	19
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	18	18
Serine/threonine-protein kinase 26	0	0	19	19
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	17	17
Serine/threonine-protein kinase NLK	0	0	19	19
5'-AMP-activated protein kinase subunit gamma-2	0	0	19	19
Serine/threonine-protein kinase TBK1	0	1	19	20
Septin-9	0	0	19	19
Ribosomal protein S6 kinase alpha-6	0	0	19	19
TRAF2 and NCK-interacting protein kinase	0	0	19	19
Serine/threonine-protein kinase TAO2	0	0	19	19
Serine/threonine-protein kinase ICK	0	0	19	19
RAC-gamma serine/threonine-protein kinase	0	0	19	19
Serine/threonine-protein kinase SIK3	0	0	19	19
Mitogen-activated protein kinase kinase kinase 2	0	0	19	19
Thyroid hormone receptor-associated protein 3	0	0	18	18
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	19	19
Receptor-interacting serine/threonine-protein kinase 3	0	2	19	21
Serine/threonine-protein kinase MRCK beta	0	0	19	19
Interleukin-1 receptor-associated kinase 3	0	0	19	19
Serine/threonine-protein kinase 24	0	0	14	14
Casein kinase I isoform gamma-3	0	0	19	19
Mitogen-activated protein kinase kinase kinase 4	0	0	19	19
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	11	0	0	11
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
RAR-related orphan receptor gamma	14	0	0	14
TDP1 protein	23	0	0	23
AR protein	23	0	0	23
nuclear receptor subfamily 1, group I, member 3	15	0	0	15
glucocorticoid receptor [Homo sapiens]	14	0	0	14
estrogen-related nuclear receptor alpha	19	0	0	19
pregnane X nuclear receptor	16	0	0	16
estrogen nuclear receptor alpha	22	0	0	22
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	12	0	0	12
nuclear factor erythroid 2-related factor 2 isoform 2	10	0	0	10
heat shock protein beta-1	6	0	0	6
importin subunit beta-1 isoform 1	3	0	0	3
snurportin-1	3	0	0	3
tumor susceptibility gene 101 protein	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
lamin isoform A-delta10	19	0	0	19
Voltage-dependent calcium channel gamma-2 subunit	10	0	0	10
Bile salt export pump	0	24	0	24
Heat shock protein HSP 90-beta	0	1	0	1
Glutamate receptor 2	11	0	0	11
Xanthine dehydrogenase/oxidase	0	1	0	1
TAR DNA-binding protein 43	4	0	0	4
Protein mono-ADP-ribosyltransferase PARP15	0	2	0	2
Leucine-rich repeat serine/threonine-protein kinase 2	0	3	6	9
ATPase family AAA domain-containing protein 5	8	0	0	8
Ataxin-2	10	0	0	10
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	5	0	0	5
Carbonic anhydrase 1	0	4	0	5
Carbonic anhydrase 2	0	5	1	7
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	2	1	4
Glutamate receptor ionotropic, NMDA 1	0	3	0	4
Proton-coupled amino acid transporter 1	0	2	0	2
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	2	0	3
EWS/FLI fusion protein	21	0	0	21
Adenine phosphoribosyltransferase	0	0	16	16
Proto-oncogene tyrosine-protein kinase ROS	0	7	7	14
Tyrosine-protein kinase Fgr	0	3	12	15
Mast/stem cell growth factor receptor Kit	0	8	6	14
UMP-CMP kinase	0	0	13	13
Phosphatidylethanolamine-binding protein 1	0	0	16	16
Myosin-10	0	0	13	13
Vascular endothelial growth factor receptor 2	0	12	7	20
Electron transfer flavoprotein subunit beta	0	0	15	15
G protein-coupled receptor kinase 6	0	0	15	15
Cysteine--tRNA ligase, cytoplasmic	0	0	16	16
Dual specificity protein kinase CLK2	0	0	17	17
Serine/threonine-protein kinase PLK1	0	4	14	18
Mitogen-activated protein kinase 10	0	0	18	18
Cyclin-dependent kinase 3	0	0	18	18
Cyclin-dependent kinase 18	0	0	9	9
Tyrosine-protein kinase Mer	0	3	14	17
Integrin-linked protein kinase	0	0	17	17
Peroxisomal acyl-coenzyme A oxidase 1	0	0	17	17
Cyclin-dependent kinase 10	0	0	9	9
Ephrin type-A receptor 7	0	0	17	17
Acyl-CoA dehydrogenase family member 10	0	0	16	16
ATP-dependent RNA helicase DHX30	0	0	16	16
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	0	0	9	9
Misshapen-like kinase 1	0	0	15	15
PAS domain-containing serine/threonine-protein kinase	0	0	13	13
Dual specificity testis-specific protein kinase 2	0	0	11	11
SRSF protein kinase 1	0	1	6	7
Echinoderm microtubule-associated protein-like 4	0	4	2	7
Serine/threonine-protein kinase PAK 6	0	1	13	14
Obg-like ATPase 1	0	0	17	17
Serine/threonine-protein kinase pim-2	0	0	14	14
ALK tyrosine kinase receptor	0	10	11	22
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	6	2	9
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	14	14
retinoic acid nuclear receptor alpha variant 1	16	0	0	16
thyroid stimulating hormone receptor	9	0	0	9
thyroid hormone receptor beta isoform 2	14	0	0	14
Heat shock protein HSP 90-alpha	0	0	1	1
Botulinum neurotoxin type A	0	2	0	2
Neutrophil cytosol factor 1	0	1	0	1
Nitric oxide synthase, endothelial	0	1	0	1
Nitric oxide synthase, brain	0	1	0	1
Nitric oxide synthase, brain	0	1	0	1
Nitric oxide synthase, inducible	0	1	0	1
Kappa-type opioid receptor	0	0	1	1
Phosphatidylinositol 4-kinase alpha	0	1	0	1
Mu-type opioid receptor	0	3	1	4
Tyrosine-protein kinase	0	0	1	1
Phosphatidylinositol 4-kinase type 2-beta	0	1	0	1
Phosphatidylinositol 4-kinase type 2-alpha	0	1	0	1
Phosphatidylinositol 4-kinase beta	0	1	6	7
SMAD family member 2	4	0	0	4
SMAD family member 3	4	0	0	4
GLI family zinc finger 3	15	0	0	15
thioredoxin glutathione reductase	2	0	0	2
progesterone receptor	10	0	0	10
farnesoid X nuclear receptor	11	0	0	11
G	16	0	0	16
peroxisome proliferator-activated receptor delta	8	0	0	8
vitamin D (1,25- dihydroxyvitamin D3) receptor	10	0	0	10
euchromatic histone-lysine N-methyltransferase 2	14	0	0	14
nuclear receptor subfamily 1, group I, member 2	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 1	14	0	0	14
ATP-binding cassette sub-family C member 3	0	18	0	18
Multidrug resistance-associated protein 4	0	18	0	19
HLA class I histocompatibility antigen, B alpha chain	16	0	0	16
Aromatase	0	7	0	7
Inositol hexakisphosphate kinase 1	16	0	0	16
Canalicular multispecific organic anion transporter 1	0	19	0	20
cytochrome P450 2C9, partial	16	0	0	16
Leukotriene C4 synthase	0	0	6	6
Membrane-associated progesterone receptor component 1	0	0	12	12
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	3	6	9
Serine/threonine-protein kinase 25	0	0	6	6
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	0	6	6
Serine/threonine-protein kinase RIO3	0	0	6	6
Dual specificity mitogen-activated protein kinase kinase 7	0	0	6	6
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	6	6
Peripheral plasma membrane protein CASK	0	0	6	6
Serine/threonine-protein kinase DCLK1	0	0	6	6
Inhibitor of nuclear factor kappa-B kinase subunit alpha	0	0	6	6
Muscle, skeletal receptor tyrosine-protein kinase	0	0	6	6
Mitogen-activated protein kinase 13	0	0	6	6
3-phosphoinositide-dependent protein kinase 1	0	1	6	7
Mitogen-activated protein kinase kinase kinase 13	0	0	6	6
Death-associated protein kinase 3	0	0	6	6
Mitogen-activated protein kinase kinase kinase 7	0	0	6	6
NUAK family SNF1-like kinase 1	0	1	6	7
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	0	0	6	6
Tyrosine-protein kinase JAK2	0	5	10	15
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	0	0	6	6
Serine/threonine-protein kinase PAK 3	0	0	6	6
Serine/threonine-protein kinase 17B	0	0	6	6
Cyclin-dependent kinase 14	0	0	6	6
Serine/threonine-protein kinase OSR1	0	0	6	6
Serine/threonine-protein kinase Chk2	0	1	6	7
RAF proto-oncogene serine/threonine-protein kinase	0	5	7	14
Receptor tyrosine-protein kinase erbB-2	0	11	9	20
Cytochrome P450 1A2	0	3	0	3
Cytochrome P450 2E1	0	2	0	2
Macrophage colony-stimulating factor 1 receptor	0	4	6	10
Wee1-like protein kinase 2	0	0	6	6
Uncharacterized serine/threonine-protein kinase SBK3	0	0	6	6
Cytochrome P450 2C8	0	3	0	4
Insulin receptor-related protein	0	0	6	6
Platelet-derived growth factor receptor alpha	0	7	6	13
Vascular endothelial growth factor receptor 1	0	5	6	11
Interferon-induced, double-stranded RNA-activated protein kinase	0	0	6	6
Serine/threonine-protein kinase MAK	0	0	6	6
Cyclin-dependent kinase 11B	0	0	6	6
Fibroblast growth factor receptor 2	0	1	6	7
Receptor tyrosine-protein kinase erbB-3	0	5	6	11
Fibroblast growth factor receptor 4	0	1	6	7
Fibroblast growth factor receptor 3	0	2	6	8
Protein kinase C eta type	0	0	6	6
Activin receptor type-2A	0	0	6	6
Ephrin type-A receptor 3	0	0	6	6
Ephrin type-A receptor 8	0	0	6	6
Leukocyte tyrosine kinase receptor	0	2	6	8
Tyrosine-protein kinase receptor UFO	0	2	6	8
Mitogen-activated protein kinase 4	0	0	6	6
G protein-coupled receptor kinase 4	0	0	6	6
Cytochrome P450 2C19	0	3	0	4
Prostaglandin G/H synthase 2	0	2	7	10
Tyrosine-protein kinase receptor Tie-1	0	0	6	6
Vascular endothelial growth factor receptor 3	0	3	6	9
Serine/threonine-protein kinase receptor R3	0	0	9	9
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	3	6	9
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	3	6	9
Serine/threonine-protein kinase mTOR	0	3	6	9
Megakaryocyte-associated tyrosine-protein kinase	0	0	6	6
Tyrosine-protein kinase TXK	0	1	7	8
Tyrosine-protein kinase ZAP-70	0	1	6	7
Dual specificity mitogen-activated protein kinase kinase 4	0	0	12	12
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	3	6	9
Cyclin-dependent kinase 8	0	1	6	7
Tyrosine-protein kinase Blk	0	1	7	8
Cytoplasmic tyrosine-protein kinase BMX	0	3	7	10
cAMP-dependent protein kinase catalytic subunit PRKX	0	0	7	7
Serine/threonine-protein kinase Nek4	0	0	6	6
Tyrosine-protein kinase JAK3	0	5	7	12
Death-associated protein kinase 1	0	0	6	6
Dipeptidyl peptidase 1	0	2	0	2
Mitogen-activated protein kinase 12	0	0	6	6
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	1	6	7
Ephrin type-B receptor 1	0	0	6	6
Hormonally up-regulated neu tumor-associated kinase	0	0	6	6
Serine/threonine-protein kinase SIK1	0	0	6	6
Receptor-interacting serine/threonine-protein kinase 4	0	0	6	6
Cell division control protein 2 homolog	0	0	6	6
Calcium-dependent protein kinase 1	0	0	6	6
Casein kinase II subunit alpha	0	0	6	6
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	0	0	6	6
SRSF protein kinase 2	0	0	6	6
Mitogen-activated protein kinase kinase kinase 9	0	0	6	6
Serine/threonine-protein kinase PknB	0	0	6	6
Cyclin-dependent kinase-like 1	0	0	6	6
Glutamate receptor ionotropic, NMDA 2B	0	3	0	4
Protein kinase C epsilon type	0	0	6	6
Angiopoietin-1 receptor	0	3	6	9
Mitogen-activated protein kinase kinase kinase 10	0	0	6	6
Tyrosine-protein kinase receptor TYRO3	0	1	6	7
Tyrosine-protein kinase ITK/TSK	0	1	7	8
Myotonin-protein kinase	0	0	6	6
Mitogen-activated protein kinase kinase kinase 12	0	0	6	6
Serine/threonine-protein kinase PAK 1	0	0	6	6
cGMP-dependent protein kinase 2	0	0	6	6
Serine/threonine-protein kinase PRP4 homolog	0	0	6	6
Receptor-interacting serine/threonine-protein kinase 1	0	2	6	8
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	0	6	6
Serine/threonine-protein kinase D1	0	1	6	7
Serine/threonine-protein kinase 38	0	0	11	11
Receptor tyrosine-protein kinase erbB-4	0	6	7	13
Ribosomal protein S6 kinase alpha-2	0	0	6	6
Rhodopsin kinase GRK1	0	0	6	6
NT-3 growth factor receptor	0	2	6	8
BDNF/NT-3 growth factors receptor	0	3	6	9
Mitogen-activated protein kinase 6	0	0	6	6
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	0	0	6	6
Serine/threonine-protein kinase SBK1	0	0	6	6
Mitogen-activated protein kinase kinase kinase 19	0	0	6	6
Serine/threonine-protein kinase TNNI3K	0	1	6	7
Serine/threonine-protein kinase Nek5	0	0	6	6
Dual serine/threonine and tyrosine protein kinase	0	1	6	7
Mitogen-activated protein kinase kinase kinase 15	0	0	6	6
Serine/threonine-protein kinase tousled-like 2	0	0	6	6
Serine/threonine-protein kinase 32C	0	0	6	6
Serine/threonine-protein kinase pim-3	0	0	6	6
Serine/threonine-protein kinase VRK2	0	0	6	6
Myosin light chain kinase family member 4	0	0	6	6
Calcium/calmodulin-dependent protein kinase type 1D	0	0	6	6
Cyclin-dependent kinase-like 3	0	0	6	6
Serine/threonine-protein kinase BRSK2	0	0	6	6
Serine/threonine-protein kinase NIM1	0	0	6	6
Serine/threonine-protein kinase ULK2	0	0	6	6
Serine/threonine-protein kinase DCLK2	0	0	6	6
Calcium/calmodulin-dependent protein kinase kinase 1	0	0	6	6
Casein kinase I isoform alpha-like	0	0	6	6
Homeodomain-interacting protein kinase 4	0	1	6	7
Myosin-IIIa	0	0	6	6
Ankyrin repeat and protein kinase domain-containing protein 1	0	0	6	6
Serine/threonine-protein kinase Nek11	0	0	6	6
Serine/threonine-protein kinase BRSK1	0	0	6	6
Serine/threonine-protein kinase 35	0	0	6	6
Serine/threonine-protein kinase Nek7	0	0	12	12
Rhodopsin kinase GRK7	0	0	6	6
Serine/threonine-protein kinase 32A	0	0	6	6
Myosin-IIIb	0	0	6	6
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	0	6	6
Cyclin-dependent kinase-like 2	0	0	6	6
Serine/threonine-protein kinase Sgk3	0	0	6	6
Atypical kinase COQ8B, mitochondrial	0	0	6	6
Calcium/calmodulin-dependent protein kinase type 1G	0	0	9	9
Cyclin-dependent kinase 15	0	0	6	6
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	0	0	6	6
Serine/threonine-protein kinase RIO1	0	0	6	6
MAP kinase-interacting serine/threonine-protein kinase 1	0	0	6	6
Serine/threonine-protein kinase RIO2	0	0	6	6
Cyclin-dependent kinase 19	0	1	6	7
Transient receptor potential cation channel subfamily M member 6	0	0	6	6
Testis-specific serine/threonine-protein kinase 1	0	1	6	7
Serine/threonine-protein kinase 33	0	0	6	6
Serine/threonine-protein kinase DCLK3	0	0	6	6
Myosin light chain kinase 2, skeletal/cardiac muscle	0	0	6	6
Homeodomain-interacting protein kinase 2	0	1	6	7
Tyrosine-protein kinase Srms	0	0	6	6
Homeodomain-interacting protein kinase 3	0	1	6	7
Serine/threonine-protein kinase PLK3	0	2	6	8
MAP kinase-interacting serine/threonine-protein kinase 2	0	2	6	8
Serine/threonine-protein kinase Nek6	0	0	6	6
SNF-related serine/threonine-protein kinase	0	0	6	6
Serine/threonine-protein kinase LATS2	0	0	6	6
Serine/threonine-protein kinase 36	0	0	6	6
Serine/threonine-protein kinase 32B	0	0	6	6
Serine/threonine-protein kinase PLK2	0	2	6	8
Serine/threonine-protein kinase MARK1	0	0	6	6
Serine/threonine-protein kinase PAK 5	0	1	6	7
eIF-2-alpha kinase GCN2	0	0	6	6
Serine/threonine-protein kinase 17A	0	0	6	6
STE20/SPS1-related proline-alanine-rich protein kinase	0	0	6	6
Ephrin type-A receptor 6	0	0	6	6
Death-associated protein kinase 2	0	0	6	6
Serine/threonine-protein kinase tousled-like 1	0	0	6	6
Long-chain-fatty-acid--CoA ligase 5	0	0	11	11
SRSF protein kinase 3	0	0	6	6
Cyclin-dependent kinase 11A	0	0	6	6
Aurora kinase C	0	0	6	6
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	0	6	6
Serine/threonine-protein kinase 38-like	0	0	11	11
Microtubule-associated serine/threonine-protein kinase 1	0	0	6	6
aldehyde dehydrogenase 1 family, member A1	12	0	0	12
Cellular tumor antigen p53	13	0	0	13
Nuclear receptor ROR-gamma	3	0	0	3
Chain A, HADH2 protein	3	0	0	3
Chain B, HADH2 protein	3	0	0	3
Chain A, 2-oxoglutarate Oxygenase	4	0	0	4
Chain A, Ferritin light chain	5	0	0	5
Chain A, Cruzipain	4	0	0	4
DNA topoisomerase	0	1	0	1
15-lipoxygenase, partial	2	0	0	2
ATAD5 protein, partial	7	0	0	7
Fumarate hydratase	10	0	0	10
NFKB1 protein, partial	2	0	0	2
thyroid stimulating hormone receptor	5	0	0	5
regulator of G-protein signaling 4	5	0	0	5
polyprotein	10	0	0	10
67.9K protein	12	0	0	12
glucocerebrosidase	2	0	0	2
putative alpha-glucosidase	1	0	0	1
alpha-galactosidase	3	0	0	3
Bloom syndrome protein isoform 1	7	0	0	7
lysosomal alpha-glucosidase preproprotein	1	0	0	1
peripheral myelin protein 22 isoform 1	5	0	0	5
hemoglobin subunit beta	3	0	0	3
cellular tumor antigen p53 isoform a	3	0	0	3
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
chromobox protein homolog 1	10	0	0	10
huntingtin isoform 2	4	0	0	4
eukaryotic translation initiation factor 2-alpha kinase 3 isoform 1 precursor	0	0	1	1
serine/threonine-protein kinase mTOR isoform 1	5	0	0	5
DNA polymerase iota isoform a (long)	10	0	0	10
nuclear receptor ROR-gamma isoform 1	5	0	0	5
geminin	22	0	0	22
survival motor neuron protein isoform d	7	0	0	7
cytochrome P450 3A4 isoform 1	5	0	0	5
M-phase phosphoprotein 8	3	0	0	3
muscleblind-like protein 1 isoform 1	6	0	0	6
relaxin receptor 1 isoform 1	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	5	1	0	6
Telomerase reverse transcriptase	0	1	0	1
Histone deacetylase 3	0	4	0	4
Type-2 restriction enzyme ScaI	0	1	0	1
Deoxyribonuclease-2-alpha	0	1	0	1
Tyrosyl-DNA phosphodiesterase 2	0	1	0	1
Deoxyribonuclease-1	0	1	0	1
Type-2 restriction enzyme PstI	0	1	0	1
Type-2 restriction enzyme EcoRI	0	1	0	1
Prothrombin	0	0	0	2
DNA ligase	0	1	0	1
Integrin beta-3	3	1	0	4
Integrin alpha-IIb	3	0	0	3
Heterogeneous nuclear ribonucleoprotein A1	0	0	1	1
DNA topoisomerase 1	0	3	3	13
Gamma-aminobutyric acid receptor subunit beta-1	5	1	0	6
Gamma-aminobutyric acid receptor subunit delta	5	1	0	6
Gamma-aminobutyric acid receptor subunit gamma-2	5	1	0	6
Gamma-aminobutyric acid receptor subunit alpha-5	5	1	0	6
Gamma-aminobutyric acid receptor subunit alpha-3	5	1	0	6
Gamma-aminobutyric acid receptor subunit gamma-1	5	1	0	6
Gamma-aminobutyric acid receptor subunit alpha-2	5	1	0	6
Type-2 restriction enzyme BamHI	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	5	1	0	6
Gamma-aminobutyric acid receptor subunit gamma-3	5	1	0	6
Gamma-aminobutyric acid receptor subunit alpha-6	5	1	0	6
Somatostatin receptor type 1	0	1	0	1
Somatostatin receptor type 2	0	1	0	1
Somatostatin receptor type 4	0	1	0	1
Somatostatin receptor type 3	0	1	0	1
Somatostatin receptor type 5	0	1	0	1
5-hydroxytryptamine receptor 2B	0	5	0	5
Type-2 restriction enzyme HindIII	0	1	0	1
D(1A) dopamine receptor	3	1	0	4
Histone deacetylase 4	0	4	0	4
Ribonuclease pancreatic	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	5	2	0	7
Gamma-aminobutyric acid receptor subunit beta-3	5	1	0	6
Gamma-aminobutyric acid receptor subunit beta-2	5	1	0	6
Inositol monophosphatase 1	4	0	0	4
DNA topoisomerase 1	0	2	0	3
Histone deacetylase 1	0	4	0	4
DNA topoisomerase 1	0	1	0	1
Integrase	0	2	0	2
Histone deacetylase 7	0	4	0	4
GABA theta subunit	5	1	0	6
Histone deacetylase 2	0	4	0	4
DNA topoisomerase type IB small subunit	0	0	1	1
Polyamine deacetylase HDAC10	0	4	0	4
Histone deacetylase 11	0	4	0	4
Histone deacetylase 8	0	4	0	4
Gamma-aminobutyric acid receptor subunit epsilon	5	1	0	6
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
Histone deacetylase 6	0	4	0	4
Histone deacetylase 9	0	4	0	4
Histone deacetylase 5	0	4	0	4
Liver carboxylesterase 1	0	0	0	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
acetylcholinesterase	6	0	0	6
phosphopantetheinyl transferase	5	0	0	5
estrogen receptor 2 (ER beta)	9	0	0	9
vitamin D3 receptor isoform VDRA	9	0	0	9
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
DNA polymerase kappa isoform 1	5	0	0	5
Chain A, Carbonic anhydrase II	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
glp-1 receptor, partial	4	0	0	4
pregnane X receptor	4	0	0	4
hypoxia-inducible factor 1 alpha subunit	8	0	0	8
USP1 protein, partial	8	0	0	8
Smad3	3	0	0	3
caspase 7, apoptosis-related cysteine protease	5	0	0	5
retinoid X nuclear receptor alpha	12	0	0	12
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
peroxisome proliferator activated receptor gamma	11	0	0	11
Carbonic anhydrase	0	1	0	1
Rac1 protein	0	0	1	1
caspase-3	5	0	0	5
IDH1	6	0	0	6
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
activating transcription factor 6	5	0	0	5
thyrotropin-releasing hormone receptor	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	5	0	0	5
v-jun sarcoma virus 17 oncogene homolog (avian)	7	0	0	7
Histone H2A.x	6	0	0	6
Caspase-7	4	0	0	4
interferon gamma precursor	0	0	0	2
prostaglandin E2 receptor EP2 subtype	0	0	0	1
thyroid hormone receptor beta isoform a	7	0	0	7
potassium voltage-gated channel subfamily H member 2 isoform d	6	0	0	6
caspase-3	4	0	0	4
peripheral myelin protein 22	10	0	0	10
Prostaglandin E synthase	0	1	0	1
Carbonic anhydrase 12	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Cytochrome c oxidase subunit 1	0	1	0	1
Cytochrome c oxidase subunit 2	0	1	0	1
Catechol O-methyltransferase	0	1	0	1
Cytochrome c oxidase subunit 2	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Procathepsin L	0	1	1	2
Aldo-keto reductase family 1 member B1	0	2	0	2
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	0	2
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Quinolone resistance protein NorA	0	2	0	2
Adenosine receptor A3	0	4	0	4
Cytochrome P450 2D6	0	2	1	3
Cytochrome P450 2C9	0	4	0	5
Neuronal acetylcholine receptor subunit beta-2	0	2	0	2
Beta-3 adrenergic receptor	0	2	0	2
Alpha-1B adrenergic receptor	0	4	0	4
Calpain-2 catalytic subunit	0	1	0	1
Alpha-2B adrenergic receptor	0	4	0	4
5-hydroxytryptamine receptor 1A	0	2	0	2
D(1A) dopamine receptor	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 4	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	2
Carbonic anhydrase 6	0	1	0	1
Sodium-dependent noradrenaline transporter	0	2	0	2
Adenosine receptor A1	0	1	0	1
Cruzipain	0	2	0	2
Sodium/hydrogen exchanger 1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Sodium-dependent serotonin transporter	0	3	1	4
Sodium-dependent serotonin transporter	0	1	1	2
Delta-type opioid receptor	0	1	1	2
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Bifunctional epoxide hydrolase 2	0	3	0	3
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Carbonic anhydrase	0	1	0	1
Alpha-1A adrenergic receptor	0	4	0	4
Carbonic anhydrase 7	0	2	0	2
Urotensin-2 receptor	0	1	0	1
Carbonic anhydrase	0	1	0	1
Ras-related protein Rab-2A	0	0	1	1
D(2) dopamine receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	2
Carbonic anhydrase	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	1
Carbonic anhydrase 9	0	4	0	4
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Sigma intracellular receptor 2	0	4	0	4
Delta carbonic anhydrase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Cyclooxygenase-2	0	1	0	1
Rap guanine nucleotide exchange factor 4	2	0	0	2
Carbonic anhydrase 15	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Carbonic anhydrase 14	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
Nucleophosmin	0	2	0	2
ATP-dependent translocase ABCB1	0	4	4	11
Cytochrome P450 3A4	0	8	0	9
Transcription factor ETV6	0	1	0	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
muscarinic acetylcholine receptor M1	2	0	0	2
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	2	0	3
Solute carrier family 22 member 1	0	2	0	4
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Acetylcholinesterase	0	4	0	4
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	0	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Solute carrier family 22 member 1	0	1	0	2
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
Solute carrier family 22 member 2	0	1	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Beta-lactamase	0	1	0	1
3-dehydroquinate dehydratase	0	0	1	1
ATP-citrate synthase	0	0	0	1
Ribonuclease T	0	0	0	1
Cell death-related nuclease 4	0	0	0	1
3-dehydroquinate dehydratase	0	0	1	1
Prolyl 4-hydroxylase	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
tyrosine-protein kinase Yes	9	0	0	9
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2	0	1	0	1
Sodium-dependent phosphate transport protein 2B	0	2	0	2
Tyrosine-protein kinase ABL1	0	2	0	2
HLA class II histocompatibility antigen gamma chain	0	2	0	2
Androgen receptor	0	1	0	1
ALK tyrosine kinase receptor	0	1	0	1
Angiopoietin-1 receptor	0	1	0	1
Lysine--tRNA ligase	0	1	0	1
Macrophage-stimulating protein receptor	0	1	0	1
Mixed lineage kinase domain-like protein	0	0	1	1
Aurora kinase A-interacting protein	0	1	0	1
endonuclease IV	6	0	0	6
LMP1 [Human herpesvirus 4]	0	0	0	3
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	3	0	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	4	0	0	4
transactivating tegument protein VP16 [Human herpesvirus 1]	0	3	0	3
nuclear receptor coactivator 3 isoform a	0	3	0	3
Thymidine kinase 2, mitochondrial	0	1	0	1
Thymidine kinase, cytosolic	0	1	0	1
Thymidine kinase	0	1	0	1
Thymidylate synthase	0	4	0	5
Thymidine kinase	0	1	0	1
Probable deoxycytidylate deaminase	0	0	0	2
Cytidine deaminase	0	1	0	4
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Thymidine kinase	0	1	0	1
Deoxynucleoside kinase	0	1	0	1
Pirin	0	2	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
GTPase KRas	0	2	0	2
Heat shock factor protein 1	0	2	0	2
interleukin 8	2	0	0	2
Matrix metalloproteinase-9	0	1	0	1
Isocitrate lyase	0	1	0	1
Thymidine kinase 2	0	1	0	1
AAA family ATPase	0	0	0	2
Reverse transcriptase/RNaseH	0	0	1	1
Serum paraoxonase/arylesterase 1	0	4	0	4
Kinesin-like protein KIF11	0	1	0	1
Nucleotide-binding oligomerization domain-containing protein 2	0	2	0	2
Serine/threonine-protein kinase B-raf	0	3	0	3
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
Regulatory protein E2	0	0	1	1
ATP-dependent translocase ABCB1	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
DNA topoisomerase 2	0	0	0	1
ATP-dependent translocase ABCB1	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	1	0	2
Caspase-3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	2	0	3
Glutamate receptor ionotropic, NMDA 2C	0	2	0	3
DNA topoisomerase 2-alpha	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	2	0	3
Tubulin beta-2B chain	0	1	1	4
Similar to alpha-tubulin isoform 1	0	1	1	4
Similar to alpha-tubulin isoform 1	0	1	0	3
Glutamate receptor ionotropic, NMDA 3B	0	2	0	3
Solute carrier organic anion transporter family member 1B3	0	4	0	5
Glutamate receptor ionotropic, NMDA 3A	0	2	0	3
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Luciferase	6	0	0	6
Skn7p	0	0	0	1
Microtubule-associated protein tau	7	0	0	7
nonstructural protein 1	3	0	0	3
arylsulfatase A	4	0	0	4
flap endonuclease 1	4	0	0	4
Vpr	1	0	0	1
Solute carrier family 22 member 8	0	0	0	1
Amyloid-beta precursor protein	2	1	0	3
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Thymidine kinase	0	1	0	1
ClpP	2	0	0	2
POU domain, class 2, transcription factor 2	0	0	0	1
Transitional endoplasmic reticulum ATPase	0	1	0	1
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	0	0	2
aryl hydrocarbon receptor	2	0	0	2
epidermal growth factor receptor isoform a precursor	1	1	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Myosin light chain kinase, smooth muscle	0	0	4	4
Sodium-dependent dopamine transporter	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
Mitogen-activated protein kinase kinase kinase 8	0	2	0	2
Histamine H2 receptor	2	0	0	2
Beta-secretase 1	0	1	0	1
Tubulin alpha-1A chain	0	0	4	4
DNA-dependent protein kinase catalytic subunit	0	3	0	3
Synaptic vesicular amine transporter	0	1	0	1
Transcription factor p65	0	1	0	1
Serine/threonine-protein kinase ULK3	0	0	2	2
Chain A, DEOXYNUCLEOSIDE KINASE	0	1	0	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Transmembrane protease serine 2	0	0	1	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Equilibrative nucleoside transporter 1	0	1	0	1
Angiotensin-converting enzyme 2	0	0	1	1
Purine nucleoside phosphorylase	0	2	0	2
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Ricin	0	1	0	1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	1	1
Purine nucleoside phosphorylase	0	0	1	2
Shiga toxin subunit A	0	1	0	1
Guanine deaminase	0	0	0	1
Chain A, Beta-lactamase	3	0	0	3
transcriptional regulator ERG isoform 3	3	0	0	3
Corticosteroid-binding globulin	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
DNA polymerase III, partial	1	0	0	1
NPYLR7B	0	0	2	2
Parkin	2	0	0	2
hexokinase-4 isoform 1	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
D(1A) dopamine receptor	1	0	0	1
glucokinase regulatory protein	1	0	0	1
DNA polymerase beta	3	0	0	3
mitogen-activated protein kinase 1	2	0	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
eyes absent homolog 2 isoform a	1	0	0	1
DNA polymerase eta isoform 1	4	0	0	4
Glutamate receptor 1	1	0	0	1
Glutamate receptor 3	1	0	0	1
Glutamate receptor 4	1	0	0	1
Single-stranded DNA cytosine deaminase	1	0	0	1
GALC protein	2	0	0	2
Chain B, Pulmonary surfactant-associated protein D	0	1	0	1
Chain A, Pulmonary surfactant-associated protein D	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
Sodium/myo-inositol cotransporter 2	0	1	0	1
Chain A, Acetylcholinesterase	0	1	0	1
Solute carrier family 22 member 3	0	2	0	2
Interstitial collagenase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Muscarinic acetylcholine receptor M4	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
Multidrug and toxin extrusion protein 2	0	2	0	2
Multidrug and toxin extrusion protein 1	0	2	0	2
serine/threonine-protein kinase PLK1	2	0	0	2
Ornithine decarboxylase	0	0	0	1
Retinoic acid receptor alpha	0	1	0	1
Retinoic acid receptor gamma	0	1	0	1
Retinoic acid receptor beta	0	1	0	1
Cellular retinoic acid-binding protein 2	0	0	1	1
Retinoic acid receptor RXR-alpha	0	1	0	1
Retinoic acid receptor RXR-beta	0	1	0	1
Retinoic acid receptor RXR-gamma	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	1
Cellular retinoic acid-binding protein 1	0	0	1	1
Olfactory receptor 51E2	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Acetylcholinesterase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Sodium channel protein type 4 subunit alpha	0	2	0	3
Cholinesterase	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Chain A, Epidermal growth factor receptor	0	1	0	1
dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	0	1
Potassium voltage-gated channel subfamily E member 1	0	2	0	2
Cytochrome P450 3A5	0	2	0	2
Potassium voltage-gated channel subfamily KQT member 1	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Sodium channel protein type 5 subunit alpha	0	3	0	3
Alpha-1A adrenergic receptor	0	1	0	1
runt-related transcription factor 1 isoform AML1b	1	0	0	1
core-binding factor subunit beta isoform 2	1	0	0	1
Estrogen receptor	0	1	0	1
Steryl-sulfatase	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
acid sphingomyelinase	2	0	0	2
Thymidylate synthase	0	2	0	2
Thymidylate synthase	0	2	0	2
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
caspase-1 isoform alpha precursor	1	0	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Bile salt export pump	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	4	0	5
Dihydrofolate reductase	0	3	0	4
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	3	0	4
Thymidylate synthase	0	3	0	3
Thymidylate synthase	0	4	0	4
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	3	2	5
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	2	0	2
Dihydrofolate reductase	0	3	0	3
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	3	0	3
Bifunctional purine biosynthesis protein ATIC	0	4	0	4
Multidrug resistance-associated protein 1	0	0	0	1
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	3	0	3
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Caspase-7	1	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	2	0	2
Solute carrier family 22 member 20	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	3	0	4
Multidrug resistance associated protein	0	1	0	2
Solute carrier family 22 member 11	0	0	0	1
Protein-arginine deiminase type-4	0	1	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
Glucocorticoid receptor	0	4	1	5
Glycine receptor subunit alpha-1	0	4	0	4
Androgen receptor	0	2	0	2
Glycine receptor subunit beta	0	4	0	4
Glycine receptor subunit alpha-2	0	4	0	4
Glycine receptor subunit alpha-3	0	4	0	4
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Chain A, NAD-dependent deacetylase	0	1	0	1
Poly [ADP-ribose] polymerase 2	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Coagulation factor VII	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
Tissue factor	0	1	0	1
NAD-dependent protein deacetylase HST2	0	1	0	1
Fatty-acid amide hydrolase 1	0	3	0	3
NAD(+) hydrolase SARM1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	2	0	2
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
NAD-dependent protein deacetylase	0	1	0	1
Lysine-specific histone demethylase 1A	0	1	0	1
Putative nucleoside diphosphate kinase	0	0	2	2
Nucleoside diphosphate kinase B	0	0	2	2
von Hippel-Lindau disease tumor suppressor	0	1	0	1
Epidermal growth factor receptor	0	2	0	2
Genome polyprotein	0	1	0	1
Tubulin alpha-1A chain	0	0	1	2
Tubulin beta chain	0	0	1	1
Tubulin beta-4A chain	0	1	1	3
Integrin alpha-V	0	1	0	1
Tubulin beta chain	0	1	1	3
60 kDa chaperonin	0	1	0	1
Tubulin alpha-3C chain	0	1	1	3
Apoptosis regulator Bcl-2	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
Substance-K receptor	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	1	0	1
Cholecystokinin receptor type A	0	2	0	2
Melanocortin receptor 5	0	2	0	2
UDP-glucuronosyltransferase 2B10	0	1	0	1
Delta-type opioid receptor	0	2	0	2
10 kDa heat shock protein, mitochondrial	0	1	0	1
Tubulin alpha-1B chain	0	1	1	3
Tubulin alpha-4A chain	0	1	1	3
Tubulin beta-4B chain	0	1	1	3
Bcl-2-like protein 1	0	1	0	1
Tubulin beta-3 chain	0	2	1	4
Tubulin beta-2A chain	0	1	1	3
Thiosulfate sulfurtransferase	0	1	0	1
Beta-tubulin	0	1	0	1
Tubulin beta-8 chain	0	1	1	3
60 kDa chaperonin	0	1	0	1
Tubulin alpha-3E chain	0	1	1	3
Tubulin alpha-1A chain	0	1	1	3
10 kDa chaperonin	0	1	0	1
Tubulin alpha-1C chain	0	1	1	3
Tubulin beta-6 chain	0	1	1	3
Tubulin beta-2B chain	0	1	1	3
Tubulin beta-1 chain	0	1	1	3
Solute carrier organic anion transporter family member 1B1	0	2	0	2
Testosterone 17-beta-dehydrogenase 3	0	1	0	1
Cytochrome P450 2B6	0	2	0	3
Nuclear receptor subfamily 4 group A member 3	0	1	0	1
Peroxiredoxin-like 2A	0	1	0	1
Platelet glycoprotein VI	0	1	0	1
Chain A, Thymidylate Synthase	0	1	0	1
Chain A, Thymidylate Synthase	0	1	0	1
Chain A, Thymidylate Synthase	0	1	0	1
Serine hydroxymethyltransferase, cytosolic	0	1	1	2
Thymidylate synthase	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	2	0	2
Gamma-aminobutyric acid	0	1	0	1
cytochrome P450 2C9 precursor	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Sodium channel protein type 9 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Chain A, AKAP9-BRAF fusion protein	0	1	0	1
Dual specificity mitogen-activated protein kinase kinase 4	0	0	1	1
Aspartyl/asparaginyl beta-hydroxylase	0	1	0	1
Ras-related C3 botulinum toxin substrate 1	0	0	1	1
5-hydroxytryptamine receptor 3E	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
5-hydroxytryptamine receptor 1A	0	3	0	3
5-hydroxytryptamine receptor 3A	0	1	0	1
5-hydroxytryptamine receptor 1B	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
Alpha-1A adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
5-hydroxytryptamine receptor 3D	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
melanocortin receptor 4	0	1	1	2
Platelet-derived growth factor receptor beta	0	2	0	2
Cyclin-C	0	1	1	2
5-hydroxytryptamine receptor 7	0	1	0	1
Vascular endothelial growth factor receptor 3	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	0	1
Alpha-synuclein	1	0	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 6	0	1	0	1
Protein delta homolog 1	0	1	2	3
Vascular endothelial growth factor receptor 2	0	1	0	1
Poly [ADP-ribose] polymerase tankyrase-2	0	0	2	2
RuvB-like 2	0	1	1	2
RuvB-like 1	0	1	0	1
apical membrane antigen 1, AMA1	1	0	0	1
C-X-C chemokine receptor type 5 isoform 1	0	1	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
C-C chemokine receptor type 6	0	1	0	1
apelin receptor	0	1	0	1
bcl-2-related protein A1	0	1	0	1
streptokinase A precursor	0	0	1	1
Endoglycoceramidase II	0	0	0	1
Protein kinase C alpha type	0	1	0	1
Estrogen receptor	0	0	1	1
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Estrogen receptor beta	0	0	1	1
Protein kinase C eta type	0	1	0	1
Sphingosine kinase 2	0	1	0	1
Sphingosine kinase 1	0	1	0	1
Protein kinase C theta type	0	1	0	1
Sphingosine 1-phosphate receptor 2	0	1	1	2
Sphingosine 1-phosphate receptor 4	0	1	1	2
Sphingosine 1-phosphate receptor 1	0	1	1	2
Sphingosine 1-phosphate receptor 3	0	1	1	2
Sphingosine 1-phosphate receptor 5	0	1	1	2
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Mast/stem cell growth factor receptor Kit	0	1	0	1
Translocator protein	0	1	0	1
Beta-adrenergic receptor kinase 1	0	1	0	1
Platelet-derived growth factor receptor alpha	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
Bromodomain-containing protein 9	0	0	1	1
Serine/threonine-protein kinase 3	0	0	1	1
Bromodomain-containing protein 7	0	0	1	1
Potassium voltage-gated channel subfamily D member 3	0	1	0	1
polyadenylate-binding protein 1	0	1	0	1
Cytochrome P450 2B1	0	1	0	1
Hypoxia-inducible factor 1-alpha	0	1	1	2
Endothelial PAS domain-containing protein 1	0	0	1	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(2)

Research Excerpts

Overview

Context

Treatment

Research

Studies (205)

Protein Targets (1,358)

Carcinomatous Meningitis

Synonyms(2)

Research Excerpts

Overview

Context

Treatment

Research

Studies (205)

Drugs Studied (92)

Protein Targets (1,358)