palmarumycin CP(1): a type of spirobisnaphthalene, which contain two naphthalene-derived c10 units bridged through a spiroketal linkage with two oxygen bridges; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 196959 |
| CHEMBL ID | 88230 |
| SCHEMBL ID | 17250054 |
| MeSH ID | M0382292 |
| Synonym |
|---|
| CHEMBL88230 , |
| palmarumycin cp(1) |
| 159933-90-1 |
| palmarumycin cp1 |
| DTXSID80166774 |
| SCHEMBL17250054 |
| bdbm50218814 |
| 8'-hydroxyspiro[2,4-dioxatricyclo[7.3.1.05,13]trideca-1(12),5,7,9(13),10-pentaene-3,4'-naphthalene]-1'-one |
| palmarumycin derivative 1 |
| EN300-26619641 |
| 5-hydroxy-4h-2',4'-dioxaspiro[naphthalene-1,3'-tricyclo[7.3.1.0,5,13]tridecane]-1'(13'),5',7',9',11'-pentaen-4-one |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Thioredoxin reductase 1, cytoplasmic | Homo sapiens (human) | IC50 (µMol) | 6.1750 | 0.0432 | 2.2655 | 5.0000 | AID213103; AID213244 |
| Thioredoxin reductase 3 | Homo sapiens (human) | IC50 (µMol) | 6.1750 | 0.3500 | 3.1167 | 5.0000 | AID213103; AID213244 |
| Thioredoxin reductase 2, mitochondrial | Homo sapiens (human) | IC50 (µMol) | 6.1750 | 0.3500 | 3.1167 | 5.0000 | AID213103; AID213244 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID101815 | Ability to inhibit the growth of MDA-MB-231 cell line | 2001 | Bioorganic & medicinal chemistry letters, Oct-08, Volume: 11, Issue:19 | New inhibitors of the thioredoxin-thioredoxin reductase system based on a naphthoquinone spiroketal natural product lead. |
| AID103912 | Ability to inhibit the growth of MCF-7 cell line | 2001 | Bioorganic & medicinal chemistry letters, Oct-08, Volume: 11, Issue:19 | New inhibitors of the thioredoxin-thioredoxin reductase system based on a naphthoquinone spiroketal natural product lead. |
| AID213244 | Inhibition of thioredoxin-1/thioredoxin reductase system | 2001 | Bioorganic & medicinal chemistry letters, Oct-08, Volume: 11, Issue:19 | New inhibitors of the thioredoxin-thioredoxin reductase system based on a naphthoquinone spiroketal natural product lead. |
| AID213103 | Inhibition of thioredoxin reductase | 2001 | Bioorganic & medicinal chemistry letters, Oct-08, Volume: 11, Issue:19 | New inhibitors of the thioredoxin-thioredoxin reductase system based on a naphthoquinone spiroketal natural product lead. |
| AID1265153 | Cytotoxicity against human CHP100 cells after 24 hrs by MTT assay | 2015 | Journal of natural products, Nov-25, Volume: 78, Issue:11 | Anteaglonialides A-F and Palmarumycins CE(1)-CE(3) from Anteaglonium sp. FL0768, a Fungal Endophyte of the Spikemoss Selaginella arenicola. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (87.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.06) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (12.50%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (87.50%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||