Allergy, Latex

Allergic reaction to products containing processed natural rubber latex such as rubber gloves, condoms, catheters, dental dams, balloons, and sporting equipment. Both T-cell mediated (HYPERSENSITIVITY, DELAYED) and IgE antibody-mediated (HYPERSENSITIVITY, IMMEDIATE) allergic responses are possible. Delayed hypersensitivity results from exposure to antioxidants present in the rubber; immediate hypersensitivity results from exposure to a latex protein.

Synonym
Hypersensitivity, Latex
Natural Rubber Latex Allergy
Rubber Latex Allergy
Latex Allergy
Rubber Allergy
Allergy, Latex
Latex Hypersensitivity

Excerpt	Reference
"Latex allergy is now an important medical, occupational, medico-legal and financial problem, and it is essential that policies are developed to reduce it."	( Wakelin, SH; White, IR, 1999)
"Latex allergy is recognized worldwide as a serious health risk."	( Afshari, A; Hayes, BB; Meade, BJ; Millecchia, L; Povoski, SP; Willard, PA, 2000)
"Latex allergy is an increasing problem among veterinarians and doctors."	( van Veen, L, 2000)
"Latex allergy is a newly emerging problem."	( Buonomo, A; de Pacuale, T; Nucera, E; Patriarca, G; Pollastrini, E; Roncallo, C; Schiavino, D, 2002)
"Latex allergy is important due to serious health impacts and widespread use of its products."	( Farzaneh, P; Hassan, ZM; Hogan, SP; Hoseini, AZ; Pourpak, Z, 2006)
"The prevalence of latex allergy is increasing in surgical patient populations."	( Bader, SO; Heitz, JW, 2010)
"Latex allergy is a health problem that mainly affects medical environments, causing anaphylactic shocks in extreme cases."	( Galicia, C; Mendoza-Hernández, G; Rodríguez-Romero, A, 2015)
"Testing for natural rubber latex allergy is still important, but increased risks of chlorhexidine and ethylene oxide allergy could not be confirmed."	( Agner, T; Garvey, LH; Ibler, KS; Jemec, GB, 2016)
"Latex allergy is a major problem worldwide due to both the severity of the symptomatology it produces and the risk groups that are exposed to it."	( García-Aguirre, A; Jiménez-Carrillo, CE; Meza-Arrayales, C; Piña-Ramos, KM; Villaruel-Flores, KP, 2022)

Excerpt	Reference
"We concluded that latex allergy is an entity for which its treatment, even nowadays, is avoidance, despite having a worldwide prevalence of 4."	( García-Aguirre, A; Jiménez-Carrillo, CE; Meza-Arrayales, C; Piña-Ramos, KM; Villaruel-Flores, KP, 2022)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	2 (0.61)	23.3326
1990's	32 (9.73)	12.5806
2000's	209 (63.53)	18.1394
2010's	73 (22.19)	28.8240
2020's	13 (3.95)	9.53

Drug	Relationship Strength	Studies	Trials
ammonium hydroxide	low	2	0
benzene	low	1	0
carbamates	low	2	0
salicylic acid	low	1	0
formaldehyde	low	1	0
histamine	low	6	0
iodine	low	1	0
methanol	low	2	0
melatonin	low	1	0
nickel	low	5	0
4-aminobenzoic acid	low	1	0
sulfites	low	4	0
albuterol	low	3	0
amantadine	low	1	0
cefuroxime	low	1	0
cimetidine	low	1	0
diphenhydramine	low	2	0
disulfiram	low	1	0
donepezil	low	1	0
fenfluramine	low	1	0
glutaral	low	2	0
haloperidol	low	1	0
lidocaine	low	3	0
letrozole	low	1	0
mepivacaine	low	1	0
methacrylic acid	low	1	0
methyl salicylate	low	2	0
ondansetron	low	1	0
oxybutynin	low	1	0
phentermine	low	1	0
propofol	low	2	0
sulfadiazine	low	1	0
thiram	low	22	0
thyroxine	low	1	0
alanine	low	1	0
sucrose	low	1	0
methacholine chloride	low	4	0
asparagine	low	1	0
tryptophan	low	1	0
arginine	low	1	0
ethylene	low	2	0
ethylene oxide	low	2	0
phencyclidine	low	9	0
isoprene	medium	141	4
methylmethacrylate	low	1	0
methylprednisolone	low	2	0
lawsone	low	2	0
n-vinyl-2-pyrrolidinone	low	1	0
propylparaben	low	3	0
benzothiazole	low	1	0
methylparaben	low	2	0
diphenylguanidine	low	1	0
4-phenylenediamine	low	2	0
pentane	low	2	0
diethylamine	low	1	0
dibenzothiazyl disulfide	low	2	0
ziram	low	1	0
ditiocarb	low	5	0
thiazoles	low	4	0
ephedrine	low	1	0
limestone	low	1	0
gentian violet	low	1	0
neutral red	low	1	0
n-isopropyl-n-phenyl-4-phenylenediamine	low	1	0
platinum	low	1	0
gold	low	1	0
barium sulfate	low	1	0
chromates	low	1	0
nickel sulfate	low	1	0
tetradecanoylphorbol acetate	low	1	0
chloroprene	low	2	0
glutamic acid	low	2	0
cefazolin	low	1	0
amoxicillin	low	2	0
cefotiam	low	1	0
salmeterol xinafoate	low	1	0
adenosine	low	1	0
trazodone hydrochloride	low	2	0
arctigenin	low	1	0
cephalosporin c	low	4	0
triazoles	low	1	0
4-o-methyl-12-o-tetradecanoylphorbol 13-acetate	low	1	0
glucuronic acid	low	1	0
n,n'-(1,2-dihydroxyethylene)bisacrylamide	low	1	0
cobalt	low	2	0
p-methoxy-n-methylphenethylamine	low	1	0
cyanates	low	7	0
beta-lactams	low	1	0
trimethoprim, sulfamethoxazole drug combination	low	1	0
oxytocin	low	4	0
cellulase	low	1	0
rocuronium	low	1	0
lignans	low	1	0
arachidonic acid	low	1	0
cocaine	low	1	0
cefamandole	low	1	0
arginine vasopressin	low	1	0
etomidate	low	1	0
captax	low	2	0
diphenylthiourea	low	2	0
curcumin	low	1	0
1,3-dibutyl-2-thiourea	low	1	0
thiourea	low	3	0
ranitidine	low	1	0
ovalbumin	low	2	0
sodium dodecyl sulfate	low	1	0
chloramine-t	low	1	0
naphthoquinones	low	2	0
rosin	low	1	0
mivacurium	low	1	0
thromboxane b2	low	2	0
zinc dibutyldithiocarbamate	low	2	0
fluticasone	low	1	0
lead	low	1	0
ramipril	low	1	0
rifamycin sv	low	1	0
chlorhexidine	low	5	0
technetium tc 99m exametazime	low	1	0
sepharose	low	1	0
rifamycins	low	1	0
hevein	medium	28	2
thimerosal	low	2	0
sodium bisulfite	low	1	0
piperidines	low	1	0
interleukin-8	low	1	0
transforming growth factor beta	low	1	0
caseins	low	1	0
carbamix	low	3	0
muramidase	low	2	0
eye	low	1	0
concanavalin a	low	1	0

Protein Targets (1,091)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
GLI family zinc finger 3	39	0	0	39
AR protein	46	0	0	46
estrogen receptor 2 (ER beta)	25	0	0	25
nuclear receptor subfamily 1, group I, member 3	28	0	0	28
progesterone receptor	26	0	0	26
retinoic acid nuclear receptor alpha variant 1	35	0	0	35
retinoid X nuclear receptor alpha	32	0	0	32
estrogen-related nuclear receptor alpha	41	0	0	41
farnesoid X nuclear receptor	26	0	0	26
pregnane X nuclear receptor	35	0	0	35
peroxisome proliferator-activated receptor delta	26	0	0	26
vitamin D (1,25- dihydroxyvitamin D3) receptor	21	0	0	21
v-jun sarcoma virus 17 oncogene homolog (avian)	26	0	0	26
Caspase-7	8	0	0	8
caspase-3	8	0	0	8
heat shock protein beta-1	21	0	0	21
Chain A, HADH2 protein	15	0	0	15
Chain B, HADH2 protein	15	0	0	15
Luciferase	24	0	0	24
thioredoxin reductase	20	0	0	20
ClpP	2	0	0	2
pregnane X receptor	9	0	0	9
RAR-related orphan receptor gamma	37	0	0	37
SMAD family member 2	13	0	0	13
SMAD family member 3	13	0	0	13
apical membrane antigen 1, AMA1	10	0	0	10
aldehyde dehydrogenase 1 family, member A1	22	0	0	22
regulator of G-protein signaling 4	14	0	0	14
glucocorticoid receptor [Homo sapiens]	33	0	0	33
estrogen nuclear receptor alpha	49	0	0	49
aryl hydrocarbon receptor	24	0	0	24
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	34	0	0	34
nuclear factor erythroid 2-related factor 2 isoform 2	8	0	0	8
thyroid hormone receptor beta isoform 2	35	0	0	35
nuclear factor erythroid 2-related factor 2 isoform 1	34	0	0	34
cytochrome P450 3A4 isoform 1	21	0	0	21
Gamma-aminobutyric acid receptor subunit pi	21	3	1	25
Neutrophil cytosol factor 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	21	3	1	25
Gamma-aminobutyric acid receptor subunit delta	21	3	1	25
Gamma-aminobutyric acid receptor subunit gamma-2	21	3	1	25
Gamma-aminobutyric acid receptor subunit alpha-5	21	3	1	25
Gamma-aminobutyric acid receptor subunit alpha-3	21	3	1	25
Gamma-aminobutyric acid receptor subunit gamma-1	21	3	1	25
Gamma-aminobutyric acid receptor subunit alpha-2	21	3	1	25
Gamma-aminobutyric acid receptor subunit alpha-4	21	3	1	25
Gamma-aminobutyric acid receptor subunit gamma-3	21	3	1	25
Gamma-aminobutyric acid receptor subunit alpha-6	21	3	1	25
Nuclear receptor ROR-gamma	11	0	0	11
Gamma-aminobutyric acid receptor subunit alpha-1	21	3	1	25
Gamma-aminobutyric acid receptor subunit beta-3	21	3	1	25
Guanine nucleotide-binding protein G	8	0	0	8
Gamma-aminobutyric acid receptor subunit beta-2	21	3	1	25
GABA theta subunit	21	3	1	25
Gamma-aminobutyric acid receptor subunit epsilon	21	3	1	25
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	21	0	0	21
Genome polyprotein	0	0	1	1
USP1 protein, partial	22	0	0	22
thyroid stimulating hormone receptor	26	0	0	26
Histone H2A.x	18	0	0	18
chromobox protein homolog 1	12	0	0	12
transcriptional regulator ERG isoform 3	4	0	0	4
geminin	27	0	0	27
Polyphenol oxidase 2	0	4	0	5
Cellular tumor antigen p53	29	0	0	29
Thiopurine S-methyltransferase	0	1	0	1
Succinate-semialdehyde dehydrogenase, mitochondrial	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Cytochrome P450 1B1	0	3	0	3
Dihydropteroate synthase	0	0	1	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	10	0	0	10
acetylcholinesterase	23	0	0	23
Microtubule-associated protein tau	16	0	0	17
cytochrome P450 family 3 subfamily A polypeptide 4	27	0	0	27
G	21	0	0	21
cytochrome P450 2D6	25	0	0	25
euchromatic histone-lysine N-methyltransferase 2	34	0	0	34
thyroid stimulating hormone receptor	24	0	0	24
nuclear receptor subfamily 1, group I, member 2	6	0	0	6
vitamin D3 receptor isoform VDRA	20	0	0	20
histone deacetylase 9 isoform 3	17	0	0	17
DNA polymerase kappa isoform 1	12	0	0	12
peripheral myelin protein 22	23	0	0	23
Voltage-dependent calcium channel gamma-2 subunit	22	0	0	22
Interferon beta	22	0	0	22
HLA class I histocompatibility antigen, B alpha chain	21	0	0	21
Glutamate receptor 2	22	2	1	25
Inositol hexakisphosphate kinase 1	21	0	0	21
ATPase family AAA domain-containing protein 5	19	0	0	19
Ataxin-2	21	0	0	21
cytochrome P450 2C9, partial	21	0	0	21
hypoxia-inducible factor 1 alpha subunit	19	0	0	19
caspase 7, apoptosis-related cysteine protease	15	0	0	15
peroxisome proliferator activated receptor gamma	24	0	0	24
caspase-3	15	0	0	15
activating transcription factor 6	21	0	0	21
Fatty-acid amide hydrolase 1	0	6	0	6
Monoglyceride lipase	0	4	0	4
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain B, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Chain A, Uncharacterized protein MJ0883	0	0	1	1
signal transducer and activator of transcription 6, interleukin-4 induced	2	0	0	2
NPYLR7B	0	0	2	2
arylsulfatase A	6	0	0	6
IDH1	14	0	0	14
glycogen synthase kinase-3 beta isoform 1	0	0	3	3
mitogen-activated protein kinase 1	14	0	0	14
flap endonuclease 1	13	0	0	13
nuclear receptor ROR-gamma isoform 1	19	0	0	19
survival motor neuron protein isoform d	10	0	0	10
high affinity choline transporter 1 isoform a	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Calcium dependent protein kinase	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
Sodium/nucleoside cotransporter 2	0	2	0	2
Rap guanine nucleotide exchange factor 3	2	0	0	2
Purine nucleoside phosphorylase	0	1	0	1
Epidermal growth factor receptor	0	2	0	2
Phosphoglycerate kinase 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Avidin	0	0	1	1
Adenosine deaminase	0	0	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Insulin receptor	0	0	0	1
Phosphoglycerate kinase 2	0	1	0	1
Heat shock protein HSP 90-alpha	0	1	1	2
Platelet-derived growth factor receptor beta	0	0	0	1
Adenosine receptor A3	0	8	2	11
Heat shock 70 kDa protein 1A	0	1	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
Fibroblast growth factor receptor 1	0	0	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	1	0	1
Endoplasmin	0	1	1	2
Inosine-5'-monophosphate dehydrogenase 1	0	1	0	1
Fibroblast growth factor receptor 2	0	0	0	1
Fibroblast growth factor receptor 4	0	0	0	1
Fibroblast growth factor receptor 3	0	0	0	1
Streptavidin	0	0	1	1
Adenosylhomocysteinase	0	0	0	1
Adenosine receptor A1	0	2	1	4
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	3	2	6
Adenosine receptor A2b	0	0	1	2
Adenosine receptor A2b	0	1	1	2
Adenylate kinase 2, mitochondrial	0	1	0	1
Adenosine receptor A1	0	2	2	5
Adenosine receptor A2a	0	1	1	3
Adenylate kinase isoenzyme 1	0	1	0	1
Phosphatidylinositol 4-kinase alpha	0	2	0	3
Adenosine receptor A1	0	0	1	1
Adenosine kinase	0	0	0	1
Adenosine deaminase	0	0	0	1
Equilibrative nucleoside transporter 2	0	2	0	2
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	3
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	1	0	1
Equilibrative nucleoside transporter 1	0	2	0	2
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	3
Solute carrier family 28 member 3	0	2	0	2
Adenosine kinase	0	1	0	2
Phosphatidylinositol 4-kinase beta	0	2	0	3
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
Adenosine transporter 1	0	0	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	14	0	0	14
Carbonic anhydrase 1	0	9	0	14
Carbonic anhydrase 2	0	11	1	18
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	2
Glutamate receptor ionotropic, NMDA 1	0	8	1	11
Proton-coupled amino acid transporter 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	0	0	2
glp-1 receptor, partial	14	0	0	14
GLS protein	18	0	0	18
ATP-binding cassette sub-family C member 3	0	17	0	17
Multidrug resistance-associated protein 4	0	17	0	18
Bile salt export pump	0	26	0	26
Beta-2 adrenergic receptor	0	2	2	4
Beta-1 adrenergic receptor	0	0	2	2
60 kDa chaperonin	0	4	0	4
60 kDa heat shock protein, mitochondrial	0	4	0	4
Beta-3 adrenergic receptor	0	0	1	1
Delta-type opioid receptor	0	2	1	3
10 kDa heat shock protein, mitochondrial	0	4	0	4
Thiosulfate sulfurtransferase	0	4	0	4
Beta-2 adrenergic receptor	0	0	1	3
60 kDa chaperonin	0	4	0	4
10 kDa chaperonin	0	4	0	4
Beta-2 adrenergic receptor	0	1	2	3
Canalicular multispecific organic anion transporter 1	0	16	0	16
ATP-dependent phosphofructokinase	15	0	0	15
NFKB1 protein, partial	6	0	0	6
EWS/FLI fusion protein	12	0	0	13
putative alpha-glucosidase	1	0	0	1
histone acetyltransferase KAT2A isoform 1	11	0	0	11
lamin isoform A-delta10	26	0	0	26
Solute carrier family 22 member 2	0	5	0	8
Solute carrier family 22 member 1	0	5	0	8
Glutamate receptor ionotropic, NMDA 2D	0	3	0	3
Glutamate receptor ionotropic, NMDA 3B	0	3	0	3
Matrix protein 2	0	1	1	2
Matrix protein 2	0	1	2	3
Spike glycoprotein	15	1	0	16
Glutamate receptor ionotropic, NMDA 2A	0	7	1	10
Glutamate receptor ionotropic, NMDA 2B	0	7	1	10
Glutamate receptor ionotropic, NMDA 2C	0	8	1	12
Glutamate receptor ionotropic, NMDA 1	0	4	0	4
Glutamate receptor ionotropic, NMDA 2A	0	4	0	4
Glutamate receptor ionotropic, NMDA 2B	0	4	0	4
Glutamate receptor ionotropic, NMDA 2C	0	3	0	3
Glutamate receptor ionotropic, NMDA 2D	0	7	1	10
Solute carrier family 22 member 1	0	7	0	9
Glutamate receptor ionotropic, NMDA 3A	0	3	0	3
Glutamate receptor ionotropic, NMDA 3B	0	7	1	10
Multidrug and toxin extrusion protein 1	0	5	0	5
Solute carrier family 22 member 2	0	7	0	9
Glutamate receptor ionotropic, NMDA 3A	0	7	1	10
Chain A, Beta-lactamase	10	0	0	10
Chain A, 2-oxoglutarate Oxygenase	13	0	0	13
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	7	0	0	7
DNA polymerase eta isoform 1	4	0	0	4
DNA polymerase iota isoform a (long)	16	0	0	16
urokinase-type plasminogen activator precursor	10	0	0	10
plasminogen precursor	10	0	0	10
urokinase plasminogen activator surface receptor precursor	10	0	0	10
Bile salt export pump	0	5	0	5
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Cytochrome P450 2C9	0	4	0	4
Beta-lactamase	0	0	0	1
Kappa-type opioid receptor	0	1	0	2
Solute carrier family 15 member 1	0	3	0	3
Solute carrier family 15 member 1	0	1	0	1
Cytochrome P450 2J2	0	4	0	4
B2 metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	2	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	2	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Chain A, ADIPOCYTE LIPID-BINDING PROTEIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	5	0	0	5
Chain A, Cruzipain	10	0	0	10
15-lipoxygenase, partial	12	0	0	12
phosphopantetheinyl transferase	21	0	0	21
TDP1 protein	27	0	0	27
thioredoxin glutathione reductase	5	0	0	5
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	5	0	0	5
Bloom syndrome protein isoform 1	9	0	0	9
cellular tumor antigen p53 isoform a	14	0	0	14
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	16	0	0	16
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	4	0	0	4
caspase-1 isoform alpha precursor	2	0	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	13	0	0	13
Prostaglandin G/H synthase 1	0	0	0	1
Trypsin	0	1	0	1
Coagulation factor VII	0	1	0	1
Aromatase	0	4	0	4
Tissue factor	0	2	0	2
Fatty acid-binding protein, adipocyte	0	1	1	2
Prostaglandin G/H synthase 2	0	2	1	4
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Histamine H2 receptor	14	2	2	20
Calmodulin	0	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	3	0	0	3
Prostaglandin G/H synthase 2	0	0	0	1
Solute carrier organic anion transporter family member 2A1	0	0	0	2
Fatty acid-binding protein 5	0	1	0	1
Fatty acid-binding protein 5	0	0	1	1
Lanosterol 14-alpha demethylase	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	5	0	5
Cytosolic phospholipase A2 gamma	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	2	0	2
Solute carrier organic anion transporter family member 1B1	0	6	0	7
cytochrome P450 2C19 precursor	8	0	0	8
cytochrome P450 2C9 precursor	5	0	0	5
Dual specificity mitogen-activated protein kinase kinase 1	0	1	0	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
alpha-galactosidase	4	0	0	4
muscarinic acetylcholine receptor M1	11	0	0	11
lethal factor (plasmid)	10	0	0	10
Cytochrome P450 3A4	0	5	0	7
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
Translocator protein	0	0	1	1
Vasopressin V2 receptor	0	3	2	6
Oxytocin receptor	0	3	3	6
Vasopressin V1a receptor	0	1	2	3
Vasopressin V1a receptor	0	3	2	5
Vasopressin V1b receptor	0	2	2	4
Vasopressin V2 receptor	0	0	1	1
Vasopressin V1b receptor	0	2	1	4
Translocator protein	0	1	0	2
Oxytocin receptor	0	2	0	2
Vasopressin V2 receptor	0	2	1	3
Neutral amino acid transporter A	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	4
Amino acid transporter	0	1	0	1
Chain A, Integrase	0	1	0	1
Chain A, Integrase	0	1	0	1
Chain A, T4 LYSOZYME	0	0	1	1
Chain A, GCN4P1	0	0	1	1
Chain B, GCN4P1	0	0	1	1
Chain C, GCN4P1	0	0	1	1
Chain A, T4 LYSOZYME	0	0	1	1
Chain A, T4 LYSOZYME	0	0	1	1
Chain A, Replicase polyprotein 1ab	0	1	0	1
Chain A, 3C-like proteinase	0	1	0	1
Endolysin	0	0	1	1
Integrin beta-3	10	1	1	12
Integrin alpha-IIb	10	1	1	12
Indoleamine 2,3-dioxygenase 1	0	5	0	6
Mu-type opioid receptor	0	3	0	4
TAR DNA-binding protein 43	10	0	0	10
Fumarate hydratase	11	0	0	11
hypothetical protein, conserved	9	0	0	9
polyprotein	11	0	0	11
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	18	0	0	18
Replicase polyprotein 1ab	0	4	0	4
thyroid hormone receptor beta isoform a	11	0	0	11
Replicase polyprotein 1ab	0	8	1	9
Proteasome subunit beta type-8	0	1	0	1
Solute carrier family 22 member 6	0	6	0	6
Solute carrier family 22 member 6	0	4	0	4
Solute carrier family 22 member 7	0	1	0	2
Solute carrier family 22 member 8	0	5	0	6
Solute carrier family 22 member 11	0	3	0	3
Solute carrier family 22 member 8	0	4	0	4
Solute carrier family 22 member 7	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	8	0	0	8
Smad3	7	0	0	7
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
acid sphingomyelinase	2	0	0	2
interleukin 8	10	0	0	10
PAX8	0	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	11	0	0	11
PINK1	2	0	0	2
67.9K protein	7	0	0	7
glucocerebrosidase	5	0	0	5
Parkin	2	0	0	2
heat shock protein 90	0	0	1	1
calcineurin A1, putative	0	0	1	1
cytochrome P450 2D6 isoform 1	5	0	0	5
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
perilipin-5	0	3	0	3
perilipin-1	0	3	0	3
potassium voltage-gated channel subfamily H member 2 isoform d	17	0	0	17
huntingtin isoform 2	10	0	0	10
importin subunit beta-1 isoform 1	3	0	0	3
ubiquitin-conjugating enzyme E2 N	0	1	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	7	0	0	7
protein AF-9 isoform a	0	0	0	3
snurportin-1	3	0	0	3
melanocortin receptor 4	0	2	0	2
CAAX prenyl protease	0	0	0	1
bcl-2-related protein A1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	3	0	3
glycogen synthase kinase-3 alpha	0	0	0	1
hexokinase HKDC1	0	1	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	2
bcl-2-like protein 11 isoform 1	0	0	1	1
Synaptojanin-2	0	1	0	1
Synaptojanin-1	0	1	0	1
Solute carrier family 22 member 3	0	5	0	6
Glutathione reductase, mitochondrial	0	4	0	6
72 kDa type IV collagenase	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Trypanothione reductase	0	1	0	1
Alpha-synuclein	8	1	1	10
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase	0	1	0	1
Multidrug and toxin extrusion protein 2	0	3	0	3
Rap guanine nucleotide exchange factor 4	1	0	0	1
Spermine oxidase	0	1	0	1
M-phase phosphoprotein 8	5	0	0	5
Solute carrier family 22 member 1	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	2	0	2
ATP-dependent translocase ABCB1	0	1	0	1
ATP-dependent translocase ABCB1	0	5	0	6
Cytochrome P450 2D6	0	4	0	4
Potassium-transporting ATPase alpha chain 1	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Histamine H2 receptor	0	7	2	9
Histamine H1 receptor	0	1	3	5
Potassium-transporting ATPase subunit beta	0	1	0	1
Aldehyde oxidase	0	1	0	1
Histamine H4 receptor	0	5	2	7
Solute carrier family 22 member 4	0	1	0	1
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Amyloid-beta precursor protein	1	5	0	7
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Muscarinic acetylcholine receptor M1	0	5	1	6
5-hydroxytryptamine receptor 2C	0	5	0	5
Tryptophan 5-hydroxylase 1	0	1	0	1
5-hydroxytryptamine receptor 2A	0	6	0	6
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	2	5
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	2	5
D	0	4	0	4
5-hydroxytryptamine receptor 1A	0	8	0	8
Alpha-2B adrenergic receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
Alpha-2A adrenergic receptor	0	3	0	3
Liver carboxylesterase 1	0	1	0	2
Sodium-dependent noradrenaline transporter	0	14	1	15
Sodium-dependent dopamine transporter	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	2	1	3
5-hydroxytryptamine receptor 1B	0	5	0	5
5-hydroxytryptamine receptor 1D	0	3	0	3
5-hydroxytryptamine receptor 1F	0	3	0	3
5-hydroxytryptamine receptor 2B	0	5	0	5
5-hydroxytryptamine receptor 6	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Sodium-dependent serotonin transporter	0	5	0	5
Sodium-dependent serotonin transporter	0	4	1	6
5-hydroxytryptamine receptor 7	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
5-hydroxytryptamine receptor 5A	0	2	0	2
5-hydroxytryptamine receptor 5B	0	2	0	2
5-hydroxytryptamine receptor 3A	0	3	1	4
Lysosomal Pro-X carboxypeptidase	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	2	3
Gamma-aminobutyric acid receptor subunit beta-2	0	2	2	4
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
D(2) dopamine receptor	0	4	0	4
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Sodium-dependent dopamine transporter	0	10	0	10
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	12	0	12
Leukotriene B4 receptor 1	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Sodium-dependent dopamine transporter	0	2	0	2
5-hydroxytryptamine receptor 4	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	10	0	10
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
5-hydroxytryptamine receptor 3B	0	3	1	4
Leukotriene B4 receptor 2	1	1	0	2
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Transporter	0	3	0	3
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Chain A, Ferritin light chain	8	0	0	8
Nrf2	2	0	0	2
ATAD5 protein, partial	11	0	0	11
alkaline phosphatase, intestinal	0	1	0	1
bromodomain adjacent to zinc finger domain 2B	7	0	0	7
toll-like receptor 9	0	2	0	2
TPA: protein transporter TIM10	0	1	0	1
thyrotropin-releasing hormone receptor	9	0	0	9
lysosomal alpha-glucosidase preproprotein	1	0	0	1
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	1	0	1
hemoglobin subunit beta	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	7	0	0	7
intestinal alkaline phosphatase precursor	0	1	0	1
pyruvate kinase PKM isoform a	4	0	0	4
DNA polymerase beta	2	0	0	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	5	0	0	5
tumor susceptibility gene 101 protein	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
muscleblind-like protein 1 isoform 1	4	0	0	4
alkaline phosphatase, germ cell type preproprotein	0	1	0	1
hypothetical protein SA1422	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	2	0	0	2
neuropeptide S receptor isoform A	5	0	0	5
Prostaglandin E synthase	0	1	0	1
Histone deacetylase 3	0	1	0	1
Acetylcholinesterase	0	3	0	3
Lysine-specific histone demethylase 1A	0	1	0	1
D-amino-acid oxidase	0	1	0	1
Phospholipase A2	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	2	0	2
Neuronal proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Cholinesterase	0	4	0	4
Heme oxygenase 1	0	1	0	1
Glutathione S-transferase P	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Replicase polyprotein 1ab	0	4	1	5
Microtubule-associated protein tau	0	2	1	4
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	0	1	0	1
Tyrosinase	0	1	0	1
Aminopeptidase N	0	1	0	1
Aminopeptidase N	0	1	0	1
Alpha-1B adrenergic receptor	0	11	0	11
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	0	2	0	2
Glycogen synthase kinase-3 beta	0	1	0	1
Amine oxidase [flavin-containing] A	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Acetylcholinesterase	0	6	2	8
Heme oxygenase 2	0	1	0	1
Alpha-1D adrenergic receptor	0	5	0	5
Amine oxidase [flavin-containing] B	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Proteasome subunit beta type-5	0	1	0	1
17-beta-hydroxysteroid dehydrogenase type 2	0	1	0	1
Alpha-1A adrenergic receptor	0	12	0	12
Glycogen synthase kinase-3 beta	0	2	0	2
Caspase-7	1	0	0	1
Histone deacetylase 4	0	1	0	1
Beta-secretase 1	0	2	0	2
Cholinesterase	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Lactoylglutathione lyase	0	1	0	1
Histone acetyltransferase p300	0	1	0	1
Serine/threonine-protein kinase PAK 1	0	1	0	1
Histone deacetylase 1	0	2	0	2
5-hydroxytryptamine receptor 4	0	1	1	2
Sodium/bile acid cotransporter	0	0	1	1
Nuclear factor erythroid 2-related factor 2	0	0	1	2
Thioredoxin reductase 1, cytoplasmic	0	2	0	3
Thioredoxin reductase 3	0	1	0	1
Sortase A	0	1	0	1
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	2	0	2
CREB-binding protein	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3	0	2	0	2
Cysteine protease	0	2	0	2
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Histone deacetylase 8	0	2	0	2
Thioredoxin reductase 2, mitochondrial	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Histone deacetylase 6	0	1	0	1
Histone deacetylase 9	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Histone deacetylase 5	0	1	0	1
Lymphocyte antigen 96	0	0	1	1
Beta lactamase (plasmid)	0	2	0	2
Carbonic anhydrase 4	0	2	0	4
Carbonic anhydrase 15	0	2	0	4
Alpha-2A adrenergic receptor	0	8	0	8
Fructose-1,6-bisphosphatase 1	0	3	0	3
D(2) dopamine receptor	0	9	1	12
Alpha-2B adrenergic receptor	0	8	0	8
Alpha-2C adrenergic receptor	0	6	0	6
D(1A) dopamine receptor	0	8	0	9
Melanocortin receptor 5	0	2	0	2
Mu-type opioid receptor	0	8	1	9
D(3) dopamine receptor	0	10	1	13
Kappa-type opioid receptor	0	6	0	6
C-C chemokine receptor type 2	0	4	0	4
5-hydroxytryptamine receptor 6	0	5	0	6
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	0	1	0	1
Thrombopoietin	5	0	0	5
5-hydroxytryptamine receptor 4	0	6	0	6
Aldo-keto reductase family 1 member B1	0	12	0	12
Muscarinic acetylcholine receptor M2	0	7	1	9
Muscarinic acetylcholine receptor M4	0	7	0	7
Muscarinic acetylcholine receptor M5	0	8	0	8
Muscarinic acetylcholine receptor M1	0	8	0	9
Angiotensin-converting enzyme	0	6	0	6
Muscarinic acetylcholine receptor M3	0	7	0	7
5-hydroxytryptamine receptor 2A	0	7	0	7
5-hydroxytryptamine receptor 2C	0	6	0	6
Histamine H1 receptor	0	8	3	11
5-hydroxytryptamine receptor 2B	0	14	0	14
Histamine N-methyltransferase	0	0	0	1
Sodium channel protein type 5 subunit alpha	0	3	0	3
Nuclear receptor subfamily 3 group C member 3	0	4	0	4
Calcium release-activated calcium channel protein 1	0	1	0	1
Protein orai-2	0	1	0	1
Protein orai-3	0	1	0	1
Histamine H3 receptor	0	1	0	2
alternatively spliced Trp4	0	0	1	1
Taste receptor type 2 member 38	0	0	1	2
PPM1D protein	3	0	0	3
nonstructural protein 1	6	0	0	6
pyruvate kinase	2	0	0	2
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
LacZ protein (plasmid)	0	0	1	1
Spike glycoprotein	0	1	0	1
beta-2 adrenergic receptor	4	0	1	5
peripheral myelin protein 22 isoform 1	6	0	0	6
type-1 angiotensin II receptor	0	1	0	1
D(1A) dopamine receptor	5	0	0	5
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
runt-related transcription factor 1 isoform AML1b	2	0	0	2
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
core-binding factor subunit beta isoform 2	2	0	0	2
polypyrimidine tract-binding protein 1 isoform a	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	4	0	0	4
serine/threonine-protein kinase PLK1	5	0	0	5
apelin receptor	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	3
Vpr	5	0	0	5
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase	0	2	0	2
pyruvate kinase PKM isoform b	1	0	0	1
Transmembrane protease serine 2	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Carbamate kinase	0	1	0	1
Retinal dehydrogenase 1	0	2	0	2
Aldehyde dehydrogenase, mitochondrial	0	2	0	2
Cytochrome P450 1A2	0	2	0	2
Procathepsin L	0	1	0	1
Ornithine decarboxylase	1	0	0	1
Replicase polyprotein 1a	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
D(4) dopamine receptor	0	4	1	7
C-X-C chemokine receptor type 2	0	2	0	2
Mitogen-activated protein kinase 3	0	1	0	1
Protein-lysine 6-oxidase	0	2	0	2
Lysine-specific demethylase 5A	0	1	0	1
Caspase-1	0	1	0	1
C-C chemokine receptor type 4	0	2	0	2
C-C chemokine receptor type 5	0	2	0	2
Gasdermin-D	0	2	0	2
Lysyl oxidase homolog 3	0	2	0	2
Inositol monophosphatase 1	4	0	0	4
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Lysyl oxidase homolog 4	0	2	0	2
Histone-lysine N-methyltransferase EHMT2	0	2	0	2
Angiotensin-converting enzyme 2	0	1	0	1
Gasdermin-D	0	2	0	2
Histone-lysine N-methyltransferase EHMT1	0	2	0	2
Lysyl oxidase homolog 2	0	2	0	2
heat shock protein 90, putative	0	0	0	3
hypothetical protein CAALFM_CR05890CA	0	0	0	2
H3 histone acetyltransferase	0	0	0	2
large T antigen	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	3	0	3
Acetylcholinesterase	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Amine oxidase [flavin-containing] A	0	2	0	2
Amine oxidase [flavin-containing] A	0	1	0	1
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	3	0	3
Choline O-acetyltransferase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	3	0	3
Cholinesterase	0	2	0	2
Acetylcholine receptor subunit epsilon	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	2	0	2
Acyl-CoA:cholesterol acyltransferase	0	1	0	1
Carboxylic ester hydrolase	0	1	0	2
Carboxylic ester hydrolase	0	3	0	3
Histamine H3 receptor	0	3	2	5
Acetylcholine receptor subunit alpha	0	1	0	1
Acetylcholine receptor subunit beta	0	1	0	1
Acetylcholine receptor subunit gamma	0	1	0	1
Acetylcholine receptor subunit delta	0	1	0	1
Acetylcholine receptor subunit delta	0	1	0	1
Acetylcholine receptor subunit alpha	0	1	0	1
Acetylcholine receptor subunit gamma	0	1	0	1
Acetylcholine receptor subunit beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	2	0	2
Cytochrome P450 11B2, mitochondrial	0	2	0	2
beta-amyloid peptide, A beta {N-terminal} [human, cerebrospinal fluid, conditioned medium of mixed-brain cell cultures, Peptide Partial, 33 aa]	1	0	0	1
alpha synuclein, partial	1	0	0	1
luciferase	2	0	0	2
tumor necrosis factor	1	0	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Androgen receptor	0	6	0	6
Substance-K receptor	0	2	0	2
Glutamate receptor ionotropic, kainate 1	1	2	1	4
Alpha-1D adrenergic receptor	0	4	0	4
Glutamate receptor ionotropic, kainate 2	1	2	1	4
Glutamate receptor ionotropic, kainate 3	1	2	0	3
Fatty-acid amide hydrolase 1	1	2	0	3
Glutamate receptor ionotropic, kainate 4	1	2	0	3
Glutamate receptor ionotropic, kainate 5	1	2	0	3
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
Metabotropic glutamate receptor 8	0	2	0	2
Metabotropic glutamate receptor 6	0	1	1	3
Excitatory amino acid transporter 4	0	1	0	1
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	1	1
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	0	2	1	3
Glutamate receptor 3	0	2	1	3
Glutamate receptor 4	0	2	1	3
Metabotropic glutamate receptor 1	0	2	1	3
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	1	2	3
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Excitatory amino acid transporter 1	0	2	0	3
Excitatory amino acid transporter 2	0	2	0	3
Excitatory amino acid transporter 3	0	2	0	3
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Metabotropic glutamate receptor 1	0	1	1	3
Metabotropic glutamate receptor 2	0	1	1	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Adenylate cyclase type 1	0	1	0	1
transient receptor potential cation channel subfamily V member 1	2	0	0	2
Cocaine esterase	0	1	0	1
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	1	0	3
Potassium channel subfamily K member 2	0	2	0	2
Albumin	0	0	1	1
Major prion protein	0	0	1	1
Vitamin D-binding protein	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	2	2
Integrin beta-1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	4	1	5
Muscarinic acetylcholine receptor M4	0	2	1	3
5-hydroxytryptamine receptor 1A	0	3	0	3
Muscarinic acetylcholine receptor M5	0	2	1	3
Beta-2 adrenergic receptor	0	3	0	3
Muscarinic acetylcholine receptor M2	0	4	1	5
Integrin alpha-4	0	1	0	1
Carbonyl reductase [NADPH] 1	0	0	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	2
Beta-1 adrenergic receptor	0	3	0	3
D(3) dopamine receptor	0	4	0	4
D(2) dopamine receptor	0	2	0	2
D(1B) dopamine receptor	0	2	0	3
Adenylate cyclase type 3	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	0	0	1
5-hydroxytryptamine receptor 3A	0	2	0	2
D(1B) dopamine receptor	0	3	0	3
Beta-3 adrenergic receptor	0	2	0	2
Adenylate cyclase type 2	0	1	0	1
Adenylate cyclase type 4	0	1	0	1
D(4) dopamine receptor	0	3	0	3
Histamine H1 receptor	0	5	1	6
C-8 sterol isomerase	0	1	0	1
Mu-type opioid receptor	0	5	0	5
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 7	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
Alpha-1A adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	2	0	2
Adenylate cyclase type 8	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
D(1A) dopamine receptor	2	1	0	3
5-hydroxytryptamine receptor 7	0	2	0	2
D(2) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
AP-2 complex subunit sigma	0	1	0	1
N-acetyltransferase Eis	0	2	0	2
Sodium channel protein type 7 subunit alpha	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
Adenylate cyclase type 6	0	1	0	1
Adenylate cyclase type 5	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	2	0	2
Calcitonin gene-related peptide type 1 receptor	0	1	0	1
Genome polyprotein	0	3	0	3
Sigma intracellular receptor 2	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Zinc finger protein 664	0	1	0	1
Vesicular acetylcholine transporter	0	1	0	1
Transporter	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Protease	0	3	0	3
Adenylyl cyclase 7	0	1	0	1
D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Transient receptor potential cation channel subfamily V member 4	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	5	0	5
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
GALC protein	3	0	0	3
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Carbonic anhydrase 12	0	2	0	4
Plasma kallikrein	0	0	0	2
Carbonic anhydrase 3	0	1	0	3
Macrophage migration inhibitory factor	0	2	0	2
Carbonic anhydrase 6	0	2	0	4
Carbonic anhydrase 5A, mitochondrial	0	1	0	3
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase 7	0	2	0	4
Carbonic anhydrase	0	0	0	3
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase 9	0	3	1	6
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Equilibrative nucleoside transporter 4	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carbonic anhydrase 13	0	1	0	3
Carbonic anhydrase 14	0	2	0	4
Carbonic anhydrase 5B, mitochondrial	0	1	0	3
Dihydroorotate dehydrogenase	0	1	0	1
Integrase	0	1	0	1
Histone-lysine N-methyltransferase SETD7	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 22	0	1	0	1
P2X purinoceptor 7	0	1	0	1
Estrogen receptor	0	1	0	1
Steryl-sulfatase	0	1	0	1
Potassium channel subfamily K member 3	0	2	0	2
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	2	0	2
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
isocitrate dehydrogenase 1, partial	5	0	0	5
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
ras-related protein Rab-9A	3	0	0	3
Nuclear receptor subfamily 1 group I member 2	0	0	3	3
Platelet-activating factor receptor	0	1	0	1
Cytochrome P450 2C19	0	2	0	2
Bile acid receptor	0	2	0	2
Sodium-dependent neutral amino acid transporter B(0)AT2	0	1	0	1
Potassium channel subfamily K member 9	0	1	0	1
Cytochrome P450 1A1	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Myeloperoxidase	0	2	0	2
Cytochrome P450 2C11	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	0	1
galanin receptor type 3	0	2	0	2
Chain E, Fibrin beta chain	0	1	0	1
T cell receptor, partial	1	0	0	1
luteinizing hormone receptor	1	0	0	1
integrase, partial	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	2	0	0	2
lens epithelium-derived growth factor p75	0	1	0	1
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	2
TSHR protein	1	0	0	1
Apoptotic peptidase activating factor 1	0	1	0	1
serine-protein kinase ATM isoform a	2	0	0	2
neutrophil cytosol factor 1	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	4	0	0	4
caspase-9 isoform alpha precursor	0	1	0	1
caspase-3 isoform a preproprotein	0	1	0	1
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
POsterior Segregation	0	0	1	1
Glutathione reductase	0	1	0	1
Glycoprotein hormones alpha chain	2	0	0	2
Albumin	0	0	0	1
Dihydrolipoyl dehydrogenase, mitochondrial	0	1	0	2
Cruzipain	0	1	0	1
Dihydrolipoyl dehydrogenase	0	1	0	2
Zinc finger protein mex-5	0	0	1	1
phosphoglycerate kinase	2	0	0	2
Xanthine dehydrogenase/oxidase	0	1	0	1
Glucocorticoid receptor	0	3	0	3
Glycine receptor subunit alpha-1	0	2	0	2
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Progesterone receptor	0	0	1	1
WRN	1	0	0	1
Endothelin receptor type B	1	0	0	1
Endothelin-1 receptor	1	0	0	1
5-hydroxytryptamine receptor 3E	0	1	1	3
5-hydroxytryptamine receptor 3A	0	0	1	1
5-hydroxytryptamine receptor 3B	0	1	1	3
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	2	0	2
Interleukin-6 receptor subunit alpha	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	0	2
5-hydroxytryptamine receptor 3A	0	2	1	4
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Thyrotropin-releasing hormone receptor	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Glycine receptor subunit alpha-4	0	1	0	1
5-hydroxytryptamine receptor 3D	0	1	1	3
5-hydroxytryptamine receptor 3C	0	1	1	3
5-hydroxytryptamine receptor 3B	0	1	0	1
Histamine H3 receptor	0	1	0	1
Leukotriene B4 receptor 1	0	1	0	1
Nischarin	0	1	0	1
MBT domain-containing protein 1	0	1	0	1
Lethal(3)malignant brain tumor-like protein 4	0	1	0	1
Muscarinic acetylcholine receptor	0	0	1	1
Lethal(3)malignant brain tumor-like protein 3	0	1	0	1
Lethal(3)malignant brain tumor-like protein 1	0	1	0	1
Oxytocin receptor	0	0	1	1
Chain A, Immunoglobulin	0	0	1	1
Chain B, Immunoglobulin	0	0	1	1
Muscarinic acetylcholine receptor M1	0	0	1	2
Cytochrome P450 2B6	0	1	0	1
Muscarinic acetylcholine receptor M4	0	0	1	2
Delta-type opioid receptor	0	0	0	1
Kappa-type opioid receptor	0	0	0	1
Muscarinic acetylcholine receptor M5	0	0	1	2
Muscarinic acetylcholine receptor M3	0	0	1	2
Muscarinic acetylcholine receptor M2	0	0	1	2
Trace amine-associated receptor 1	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Angiotensin-converting enzyme	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	2
Solute carrier organic anion transporter family member 2B1	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
B-cell lymphoma 6 protein	0	0	1	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	1	0	2
DNA-directed RNA polymerase subunit beta	0	1	0	1
Sphingosine kinase 2	0	2	0	2
Sphingosine kinase 1	0	1	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Albumin	0	1	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	1	1	2
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
LMP1 [Human herpesvirus 4]	0	0	0	1
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Peroxisome proliferator-activated receptor alpha	1	0	0	1
Chain A, MALTOPORIN	0	0	1	1
Chain B, MALTOPORIN	0	0	1	1
Aurora kinase A	0	1	0	1
nonstructural protein 1	0	1	0	1
Serine/threonine-protein kinase D3	0	0	1	1
Protein kinase C gamma type	0	1	1	2
Protein kinase C beta type	0	1	1	2
Luciferin 4-monooxygenase	0	0	1	1
Protein kinase C alpha type	0	1	1	2
Protein kinase C eta type	0	0	1	1
Protein kinase C iota type	0	0	1	1
Protein kinase C epsilon type	0	1	1	2
Protein kinase C theta type	0	0	1	1
Protein kinase C zeta type	0	0	1	1
Protein kinase C delta type	0	1	1	2
Serine/threonine-protein kinase D1	0	0	1	1
Ras guanyl-releasing protein 3	0	0	1	1
caspase recruitment domain family, member 15	0	1	0	1
neurotensin receptor type 1	0	0	1	1
receptor-interacting serine/threonine-protein kinase 2 isoform 1	0	1	0	1
Alcohol dehydrogenase E chain	0	1	0	1
Alcohol dehydrogenase S chain	0	1	0	1
Urease	0	2	0	3
Urease subunit alpha	0	1	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Urease subunit beta	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Janus kinase 2 (a protein tyrosine kinase)	0	1	0	1
fructose-bisphosphate aldolase A	1	0	0	1
glyceraldehyde-3-phosphate dehydrogenase isoform 1	1	0	0	1
E3 ubiquitin-protein ligase Mdm2 isoform a	0	0	1	1
Gamma-butyrobetaine dioxygenase	0	1	1	2
Substance-K receptor	0	0	1	1
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Transthyretin	0	1	0	2
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Retinoic acid receptor RXR-alpha	0	0	2	2
UDP-glucuronosyltransferase 1A1	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Dihydrofolate reductase	0	2	0	2
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Substance-P receptor	0	1	0	1
Tryptophan 2,3-dioxygenase	0	1	0	2
Large neutral amino acids transporter small subunit 1	0	1	0	1
SLC16A10 protein	0	0	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Monocarboxylate transporter 10	0	0	0	1
Phospholipase A-2-activating protein	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(7)

Research Excerpts

Overview

Treatment

Research

Studies (329)

Protein Targets (1,091)

Allergy, Latex

Synonyms(7)

Research Excerpts

Overview

Treatment

Research

Studies (329)

Drugs Studied (148)

Protein Targets (1,091)