epothilone

Any member of the class of 16-membered macrolide natural products, or their analogues, normally containing a double bond or its epoxide at positions 12-13 and bearing hydroxy groups at positions 4 and 8, methyl groups at positions 5, 5, 7, and 9, an oxo group at position 6, and a 1-(2-substituted-1,3-thiazol-4-yl)prop-1-en-2-yl substituent at position 15.

ChEBI ID: 60831

Members (4)

Member	Definition	Role
desoxyepothilone a	An epothilone that is 1-oxacyclohexadec-13-ene-2,6-dione which is substituted by hydroxy groups at positions 4 and 9, methyl groups at positions 5, 5, 7, and 9, and by a (1E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl group at position 16 (the 4S,7R,8S,9S,13Z,16S stereoisomer).	epothilone C
desoxyepothilone b	An epithilone that is epithilone C in which the hydrogen at position 13 of the oxacyclohexadec-13-ene-2,6-dione macrocycle has been replaced by a methyl group.	epothilone D
epothilone a	An epithilone that is epothilone C in which the double bond in the macrocyclic lactone ring has been oxidised to the corresponding epoxide (the 13R,14S diastereoisomer).	epothilone A
epothilone b	An epithilone that is epithilone D in which the double bond in the macrocyclic ring has been oxidised to the corresponding epoxide (the S,S stereoisomer).	epothilone B

Research

Studies (911)

Timeframe	Studies, Drugs in This Class (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	26 (2.85)	18.2507
2000's	439 (48.19)	29.6817
2010's	401 (44.02)	24.3611
2020's	45 (4.94)	2.80

Study Types

Publication Type	Studies, Drugs in This Class (%)	All Drugs (%)
Trials	174 (13.08%)	5.53%
Reviews	249 (18.72%)	6.00%
Case Studies	10 (0.75%)	4.05%
Observational	1 (0.08%)	0.25%
Other	896 (67.37%)	84.16%