Page last updated: 2024-08-05 13:04:31
epothilone
Any member of the class of 16-membered macrolide natural products, or their analogues, normally containing a double bond or its epoxide at positions 12-13 and bearing hydroxy groups at positions 4 and 8, methyl groups at positions 5, 5, 7, and 9, an oxo group at position 6, and a 1-(2-substituted-1,3-thiazol-4-yl)prop-1-en-2-yl substituent at position 15.
ChEBI ID: 60831
Members (4)
| Member | Definition | Role |
|---|---|---|
| desoxyepothilone a | An epothilone that is 1-oxacyclohexadec-13-ene-2,6-dione which is substituted by hydroxy groups at positions 4 and 9, methyl groups at positions 5, 5, 7, and 9, and by a (1E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl group at position 16 (the 4S,7R,8S,9S,13Z,16S stereoisomer). | epothilone C |
| desoxyepothilone b | An epithilone that is epithilone C in which the hydrogen at position 13 of the oxacyclohexadec-13-ene-2,6-dione macrocycle has been replaced by a methyl group. | epothilone D |
| epothilone a | An epithilone that is epothilone C in which the double bond in the macrocyclic lactone ring has been oxidised to the corresponding epoxide (the 13R,14S diastereoisomer). | epothilone A |
| epothilone b | An epithilone that is epithilone D in which the double bond in the macrocyclic ring has been oxidised to the corresponding epoxide (the S,S stereoisomer). | epothilone B |
Research
Studies (911)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 26 (2.85) | 18.2507 |
| 2000's | 439 (48.19) | 29.6817 |
| 2010's | 401 (44.02) | 24.3611 |
| 2020's | 45 (4.94) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 174 (13.08%) | 5.53% |
| Reviews | 249 (18.72%) | 6.00% |
| Case Studies | 10 (0.75%) | 4.05% |
| Observational | 1 (0.08%) | 0.25% |
| Other | 896 (67.37%) | 84.16% |