Page last updated: 2024-10-14

chlorantranilipole

Description

chlorantranilipole: anthranilic diamide insecticide.that disrupts mating in codling moth (Lepidoptera: Tortricidae) [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

chlorantraniliprole : A carboxamide resulting from the formal condensation of the carboxylic acid group of 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid with the primary amino group of 2-amino-5-chloro-N,3-dimethylbenzamide. The first of the anthranilic diamide insecticides, it is a ryanodine receptor activator and is used to protect a wide variety of crops, including corn, cotton, grapes, rice and potatoes. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID11271640
CHEMBL ID399318
CHEBI ID67113
SCHEMBL ID29551
MeSH IDM0507389

Synonyms (51)

Synonym
chlorantraniliprole
chebi:67113 ,
CHEMBL399318 ,
bdbm50222771
3-bromo-n-(4-chloro-2-methyl-6-(methylcarbamoyl)phenyl)-1-(3-chloropyridin-2-yl)-1h-pyrazole-5-carboxamide ,
C18454
A827923
500008-45-7
5-bromo-n-[2-chloro-4-methyl-6-(methylcarbamoyl)phenyl]-2-(3-chloro-2-pyridinyl)-3-pyrazolecarboxamide
622ak9dh9g ,
rynaxypyr
hsdb 7877
3-bromo-n-(4-chloro-2-methyl-6-((methylamino)carbonyl)phenyl)-1-(3-chloro-2-pyridinyl)-1h-pyrazole-5-carboxamide
chlorantranilipole
unii-622ak9dh9g
3-bromo-4-chloro-1-(3-chloro-2-pyridyl)-2'-methyl-6-(methylcarbamoyl)pyrazole-5'carboxanilide
dpx-e2y45
chlorantraniliprole [iso]
3-bromo-n-[4-chloro-2-methyl-6-[(methylamino)carbonyl]phenyl]-1-(3-chloro-2-pyridinyl)-1h-pyrazole-5-carboxamide
rynaxpyr
3-bromo-n-{4-chloro-2-methyl-6-[(methylamino)carbonyl]phenyl}-1-(3-chloro-2-pyridinyl)-1h-pyrazole-5-carboxamide
3-bromo-n-[4-chloro-2-methyl-6-(methylcarbamoyl)phenyl]-1-(3-chloropyridin-2-yl)-1h-pyrazole-5-carboxamide
AKOS015895788
chlorantraniliprole [mi]
3-bromo-4'-chloro-1-(3-chloro-2-pyridyl)-2'-methyl-6'-(methylcarbamoyl)pyrazole-5-carboxanilide
SCHEMBL29551
3-bromo-n-[4-chloro-2-methyl-6-[(methylamino)-carbonyl]phenyl]-1-(3-chloro-2-pyridinyl)-1h-pyrazole-5-carboxamide
3-bromo-n-[4-chloro-2-methyl-6-[(methylamino)carbonyl]phenyl]-1-(3- chloro-2-pyridinyl)-1h-pyrazole-5-carboxamide
PSOVNZZNOMJUBI-UHFFFAOYSA-N
3-bromo-n-[4-chloro-2-methyl-6-[(methyl-amino)carbonyl]phenyl]-1-(3-chloro-2-pyridinyl)-1h-pyrazole-5-carboxamide
3-bromo-n-[4-chloro-2-methyl-6- [(methylamino)carbonyl]phenyl]-1-(3-chloro-2-pyridinyl)-1h-pyrazole-5-carboxamide
DTXSID2044345 ,
chloantraniliprole
mfcd11840831
3-bromo-4-chloro-1-(3-chloro-2-pyridyl)-2?-methyl-6-(methylcarbamoyl)pyrazole-5-carboxanilide
chlorantraniliprole, pestanal(r), analytical standard
5-bromanyl-n-[4-chloranyl-2-methyl-6-(methylcarbamoyl)phenyl]-2-(3-chloranylpyridin-2-yl)pyrazole-3-carboxamide
f0u ,
pesticide4_chlorantraniliprole_c18h14brcl2n5o2_3-bromo-n-[4-chloro-2-methyl-6-(methylcarbamoyl)phenyl]-1-(3-chloropyridin-2-yl)-1h-pyrazole-5-carboxamide
DS-9084
CS-0065743
HY-112820
Q2301181
chlorantraniliprole 100 microg/ml in acetonitrile
BCP12712
5-bromo-n-[4-chloro-2-methyl-6-(methylcarbamoyl)phenyl]-2-(3-chloropyridin-2-yl)pyrazole-3-carboxamide
dki 0001
coragen
dtxcid0024345
1h-pyrazole-5-carboxamide, 3-bromo-n-
usepa/opp pesticide code: 090100

Toxicity

ExcerptReference
"The aquatic 96 h median lethal toxicity (LC(50)) data indicate that technical-grade chlorantraniliprole is highly toxic (US EPA category) to crayfish with an LC(50) of 951 microg L(-1) (95% CL = 741-1118 microg L(-1))."( Acute toxicity of chlorantraniliprole to non-target crayfish (Procambarus clarkii) associated with rice-crayfish cropping systems.
Barbee, GC; Lanka, SK; McClain, WR; Stout, MJ, 2010
)
" Thiamethoxam was much less toxic than insecticides previously tested."( Toxicity of thiamethoxam and mixtures of chlorantraniliprole plus acetamiprid, esfenvalerate, or thiamethoxam to neonates of oriental fruit moth (Lepidoptera: Tortricidae).
Jones, MM; Robertson, JL; Weinzierl, RA, 2012
)
" Chlorantraniliprole was highly toxic to termite workers in brief and continuous exposure assays across arange of concentrations from 5 to 100 ppm."( Toxicity and horizontal transfer of chlorantraniliprole in the eastern subterranean termite.
Bennetti, GW; Buczkowski, G; Scherer, CW, 2012
)
" The evaluation of the chorion of the eggshell in this study has clarified the toxic effect of methomyl and cartap hydrochloride on eggs."( Insecticide toxicity to the borer Neoleucinodes elegantalis (Guenée) (Lepidoptera: Crambidae): developmental and egg-laying effects.
Arcanjo, LP; Costa, ÁH; Ferreira, DO; Martins, JC; Picanço, MC; Serrão, JE; Silva, RS; Soares, JRS, 2018
)
" However, the underlying toxic mechanisms remain unclear."( Evaluation of the Two Typical Diamide Insecticide-Induced Oxidative Damages and the Molecular Mechanism Underlying Their Toxicity in
Du, F; Feng, CX; Hou, X; Zhou, DF, 2023
)

Bioavailability

ExcerptReference
" The bioavailability of indoxacarb and chlorantraniliprole was negatively correlated with soil organic matter."( Bioavailability of chlorantraniliprole and indoxacarb to eastern subterranean termites (Isoptera: Rhinotermitidae) in various soils.
Kamble, ST; Siegfried, BD; Spomer, NA, 2009
)
" Four experiments were conducted: a topical bioassay, a horizontal transfer study, an insecticide bioavailability test and a feeding bioassay."( Toxicity and horizontal transfer of chlorantraniliprole against the Asian subterranean termite Coptotermes gestroi (Wasmann): effects of donor:recipient ratio, exposure duration and soil type.
Hu, J; Lee, CY; Neoh, KB; Yeoh, BH, 2012
)
"To evaluate the effect of biochar amendment on the bioavailability of chlorantraniliprole (CAP) in soils with different physico-chemical properties, the uptake of CAP from various soils by earthworms was studied."( Effect of biochar amendment on the bioavailability of pesticide chlorantraniliprole in soil to earthworm.
Cheng, J; Jiang, W; Liu, XJ; Wang, TT; Yu, XY; Zhang, CL, 2012
)

Dosage Studied

ExcerptReference
" Mating was disrupted when either sex was topically dosed with technical material (0."( Disruption of mating in codling moth (Lepidoptera: Tortricidae) by chlorantranilipole, an anthranilic diamide insecticide.
Flexner, L; Knight, AL, 2007
)
" Dose-response data showed that although all CSIs have a similar mechanism of action, the relative extent of toxicity may differ (novaluron > lufenuron > teflubenzuron)."( Comparative effects of insecticides with different mechanisms of action on Chrysoperla externa (Neuroptera: Chrysopidae): lethal, sublethal and dose-response effects.
Dionel Grutzmacher, A; Heres Lopes, I; Joao Zotti, M; Smagghe, G, 2013
)
" An increased dosage of cyantraniliprole did not influence on its translocation in plant tissues, however, it influenced on the present amount of active ingredient."( Translocation of chlorantraniliprole and cyantraniliprole applied to corn as seed treatment and foliar spraying to control Spodoptera frugiperda (Lepidoptera: Noctuidae).
Carús Guedes, JV; Melo, AA; Perini, CR; Pes, MP; Silva, FMA; Stacke, RS; Zanella, R, 2020
)
" This study investigated the response of root-associated bacterial microbiota to CAP dosage during the two developmental phases of rice."( Variations of root-associated bacterial cooccurrence relationships in paddy soils under chlorantraniliprole (CAP) stress.
Li, Y; Qin, Y; Wang, C; Wu, R; Xu, F; Zhou, F; Zhu, D, 2021
)
" Our results demonstrated that bioassays should be evaluated at 14 d after exposure to optimize interpretation of the dose-response due to the antifeeding properties of chlorantraniliprole."( Susceptibility of North Carolina Chloridea (Heliothis) virescens (Lepidoptera: Noctuidae) Populations From Flue Cured Tobacco to Chlorantraniliprole.
Burrack, HJ; Zilnik, G, 2021
)
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
ryanodine receptor agonistA ryanodine receptor modulator which activates the receptor. Ryanodine receptors (RyRs) act as selective ion channels, modulating the release of calcium. Activating the receptors causes the release of calcium, so depleting internal calcium and ultimately preventing further muscle contraction.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (6)

ClassDescription
organobromine compoundA compound containing at least one carbon-bromine bond.
pyridinesAny organonitrogen heterocyclic compound based on a pyridine skeleton and its substituted derivatives.
pyrazoles
pyrazole insecticide
monochlorobenzenesAny member of the class of chlorobenzenes containing a mono- or poly-substituted benzene ring in which only one substituent is chlorine.
secondary carboxamideA carboxamide resulting from the formal condensation of a carboxylic acid with a primary amine; formula RC(=O)NHR(1).
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (5)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Ryanodine receptorBemisia tabaciIC50 (µMol)0.00200.00200.00200.0020AID1112870
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Ryanodine receptorDrosophila melanogaster (fruit fly)EC50 (µMol)0.02000.00000.02000.0400AID309993; AID420809
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (38)

Processvia Protein(s)Taxonomy
response to hypoxiaRyanodine receptor 2Homo sapiens (human)
regulation of heart rateRyanodine receptor 2Homo sapiens (human)
embryonic heart tube morphogenesisRyanodine receptor 2Homo sapiens (human)
left ventricular cardiac muscle tissue morphogenesisRyanodine receptor 2Homo sapiens (human)
cardiac muscle hypertrophyRyanodine receptor 2Homo sapiens (human)
detection of calcium ionRyanodine receptor 2Homo sapiens (human)
calcium ion transportRyanodine receptor 2Homo sapiens (human)
intracellular calcium ion homeostasisRyanodine receptor 2Homo sapiens (human)
positive regulation of heart rateRyanodine receptor 2Homo sapiens (human)
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionRyanodine receptor 2Homo sapiens (human)
regulation of cardiac muscle contraction by calcium ion signalingRyanodine receptor 2Homo sapiens (human)
release of sequestered calcium ion into cytosol by sarcoplasmic reticulumRyanodine receptor 2Homo sapiens (human)
response to muscle activityRyanodine receptor 2Homo sapiens (human)
calcium-mediated signalingRyanodine receptor 2Homo sapiens (human)
response to caffeineRyanodine receptor 2Homo sapiens (human)
response to muscle stretchRyanodine receptor 2Homo sapiens (human)
release of sequestered calcium ion into cytosolRyanodine receptor 2Homo sapiens (human)
positive regulation of sequestering of calcium ionRyanodine receptor 2Homo sapiens (human)
regulation of cytosolic calcium ion concentrationRyanodine receptor 2Homo sapiens (human)
establishment of localization in cellRyanodine receptor 2Homo sapiens (human)
response to redox stateRyanodine receptor 2Homo sapiens (human)
regulation of cardiac muscle contractionRyanodine receptor 2Homo sapiens (human)
cardiac muscle contractionRyanodine receptor 2Homo sapiens (human)
calcium ion transport into cytosolRyanodine receptor 2Homo sapiens (human)
sarcoplasmic reticulum calcium ion transportRyanodine receptor 2Homo sapiens (human)
cellular response to caffeineRyanodine receptor 2Homo sapiens (human)
cellular response to epinephrine stimulusRyanodine receptor 2Homo sapiens (human)
establishment of protein localization to endoplasmic reticulumRyanodine receptor 2Homo sapiens (human)
ventricular cardiac muscle cell action potentialRyanodine receptor 2Homo sapiens (human)
Purkinje myocyte to ventricular cardiac muscle cell signalingRyanodine receptor 2Homo sapiens (human)
cell communication by electrical coupling involved in cardiac conductionRyanodine receptor 2Homo sapiens (human)
type B pancreatic cell apoptotic processRyanodine receptor 2Homo sapiens (human)
positive regulation of the force of heart contractionRyanodine receptor 2Homo sapiens (human)
regulation of AV node cell action potentialRyanodine receptor 2Homo sapiens (human)
regulation of SA node cell action potentialRyanodine receptor 2Homo sapiens (human)
regulation of atrial cardiac muscle cell action potentialRyanodine receptor 2Homo sapiens (human)
regulation of ventricular cardiac muscle cell action potentialRyanodine receptor 2Homo sapiens (human)
striated muscle contractionRyanodine receptor 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (12)

Processvia Protein(s)Taxonomy
ryanodine-sensitive calcium-release channel activityRyanodine receptor 2Homo sapiens (human)
calcium channel activityRyanodine receptor 2Homo sapiens (human)
calcium ion bindingRyanodine receptor 2Homo sapiens (human)
protein bindingRyanodine receptor 2Homo sapiens (human)
calmodulin bindingRyanodine receptor 2Homo sapiens (human)
intracellularly gated calcium channel activityRyanodine receptor 2Homo sapiens (human)
enzyme bindingRyanodine receptor 2Homo sapiens (human)
protein kinase A catalytic subunit bindingRyanodine receptor 2Homo sapiens (human)
protein kinase A regulatory subunit bindingRyanodine receptor 2Homo sapiens (human)
identical protein bindingRyanodine receptor 2Homo sapiens (human)
suramin bindingRyanodine receptor 2Homo sapiens (human)
calcium-induced calcium release activityRyanodine receptor 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (10)

Processvia Protein(s)Taxonomy
sarcoplasmic reticulum membraneRyanodine receptor 2Homo sapiens (human)
plasma membraneRyanodine receptor 2Homo sapiens (human)
junctional sarcoplasmic reticulum membraneRyanodine receptor 2Homo sapiens (human)
membraneRyanodine receptor 2Homo sapiens (human)
sarcoplasmic reticulumRyanodine receptor 2Homo sapiens (human)
Z discRyanodine receptor 2Homo sapiens (human)
sarcoplasmic reticulum membraneRyanodine receptor 2Homo sapiens (human)
protein-containing complexRyanodine receptor 2Homo sapiens (human)
calcium channel complexRyanodine receptor 2Homo sapiens (human)
Z discRyanodine receptor 2Homo sapiens (human)
sarcolemmaRyanodine receptor 2Homo sapiens (human)
smooth endoplasmic reticulumRyanodine receptor 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (154)

Assay IDTitleYearJournalArticle
AID1083114Pesticidal activity against Tetranychus cinnabarinus (carmine spider mite) third- instar larvae grown on Phaseolus vulgaris leaves assessed as pest mortality at 50 mg/L measured 48 hr post compound exposure2012Journal of agricultural and food chemistry, Nov-07, Volume: 60, Issue:44
Synthesis and bioactivity study of 2-acylamino-substituted N'-benzylbenzohydrazide derivatives.
AID420808Activation of Heliothis virescens recombinant ryanodine receptor2009Bioorganic & medicinal chemistry, Jun-15, Volume: 17, Issue:12
New and selective ryanodine receptor activators for insect control.
AID1083110Pesticidal activity against Tetranychus cinnabarinus (carmine spider mite) third- instar larvae grown on Phaseolus vulgaris leaves assessed as pest mortality at 25 mg/L measured 48 hr post compound exposure2012Journal of agricultural and food chemistry, Nov-07, Volume: 60, Issue:44
Synthesis and bioactivity study of 2-acylamino-substituted N'-benzylbenzohydrazide derivatives.
AID1081801Insecticidal activity against second-instar larval stage of Plutella xylostella (diamondback moth) in cabbage leaves assessed as mortality at 10 mg/l at 25 +/-1 degC treated for 3 secs before larva infestation measured after 2 days by leaf-dip method2010Journal of agricultural and food chemistry, Dec-08, Volume: 58, Issue:23
Synthesis and insecticidal activities of novel anthranilic diamides containing modified N-pyridylpyrazoles.
AID1111848Resistance factor, LC50 for Spodoptera exigua F11 neonate larvae to LC50 for Spodoptera exigua SS neonate larvae2011Pest management science, Nov, Volume: 67, Issue:11
Assessment of resistance risk in Spodoptera exigua (Hübner) (Lepidoptera: Noctuidae) to chlorantraniliprole.
AID1082926Insecticidal activity against Mythimna separata (Oriental armyworm) fourth-instar larvae infected Zea mays leaves assessed as larvicidal activity at 10 mg/L measured 2 days post dose2012Journal of agricultural and food chemistry, Aug-08, Volume: 60, Issue:31
Synthesis and insecticidal activities of novel anthranilic diamides containing acylthiourea and acylurea.
AID1082896Inhibition of voltage-dependent L-type calcium channel in Spodoptera exigua neurons assessed as peak calcium current at 0.1 mM measured 2 min post dose by electrophysiology method (Rvb = 102.75 +/- 2.45%)2012Journal of agricultural and food chemistry, Aug-08, Volume: 60, Issue:31
Synthesis and insecticidal activities of novel anthranilic diamides containing acylthiourea and acylurea.
AID1082899Insecticidal activity against Plutella xylostella (diamondback moth) s-instar larvae infected in fresh cabbage leaves assessed as larvicidal activity measured 2 days post dose2012Journal of agricultural and food chemistry, Aug-08, Volume: 60, Issue:31
Synthesis and insecticidal activities of novel anthranilic diamides containing acylthiourea and acylurea.
AID1081794Insecticidal activity against second-instar larval stage of Plutella xylostella (diamondback moth) in cabbage leaves assessed as mortality at 25 +/-1 degC treated for 3 secs before larva infestation measured after 2 days by leaf-dip method2010Journal of agricultural and food chemistry, Dec-08, Volume: 58, Issue:23
Synthesis and insecticidal activities of novel anthranilic diamides containing modified N-pyridylpyrazoles.
AID420800Solubility in water at 20 degC2009Bioorganic & medicinal chemistry, Jun-15, Volume: 17, Issue:12
New and selective ryanodine receptor activators for insect control.
AID309989Insecticidal activity against Spodoptera frugiperda2007Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22
Rynaxypyr: a new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator.
AID323210Lipophilicity, log P of the compound2008Bioorganic & medicinal chemistry, Mar-15, Volume: 16, Issue:6
Synthesis of insecticidal fluorinated anthranilic diamides.
AID309991Insecticidal activity against Heliothis virescens2007Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22
Rynaxypyr: a new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator.
AID1082920Insecticidal activity against Plutella xylostella (diamondback moth) s-instar larvae infected in fresh cabbage leaves assessed as larvicidal activity at 0.1 mg/L measured 2 days post dose2012Journal of agricultural and food chemistry, Aug-08, Volume: 60, Issue:31
Synthesis and insecticidal activities of novel anthranilic diamides containing acylthiourea and acylurea.
AID420812Activation of ryanodine receptor in human IMR32 cells assessed as induction of calcium mobilization2009Bioorganic & medicinal chemistry, Jun-15, Volume: 17, Issue:12
New and selective ryanodine receptor activators for insect control.
AID1081803Insecticidal activity against fourth-instar larval stage of Mythimna separata (Oriental armyworm) in compound pretreated Zea mays L. Tangyu 10 leaves assessed as mortality at 2.5 mg/l at 25 +/-1 degC after 2 days2010Journal of agricultural and food chemistry, Dec-08, Volume: 58, Issue:23
Synthesis and insecticidal activities of novel anthranilic diamides containing modified N-pyridylpyrazoles.
AID1082914Inhibition of voltage-dependent L-type calcium channel in Spodoptera exigua neurons assessed as peak calcium current at 0.1 mM measured 4 min post dose by electrophysiology method (Rvb = 99.66 +/- 1.64%)2012Journal of agricultural and food chemistry, Aug-08, Volume: 60, Issue:31
Synthesis and insecticidal activities of novel anthranilic diamides containing acylthiourea and acylurea.
AID1082919Insecticidal activity against Plutella xylostella (diamondback moth) s-instar larvae infected in fresh cabbage leaves assessed as larvicidal activity at 1 mg/L measured 2 days post dose2012Journal of agricultural and food chemistry, Aug-08, Volume: 60, Issue:31
Synthesis and insecticidal activities of novel anthranilic diamides containing acylthiourea and acylurea.
AID1081800Insecticidal activity against second-instar larval stage of Plutella xylostella (diamondback moth) in cabbage leaves assessed as mortality at 5 mg/l at 25 +/-1 degC treated for 3 secs before larva infestation measured after 2 days by leaf-dip method2010Journal of agricultural and food chemistry, Dec-08, Volume: 58, Issue:23
Synthesis and insecticidal activities of novel anthranilic diamides containing modified N-pyridylpyrazoles.
AID1104914Toxicity in Orius insidiosus infested green bean leaves assessed as mortality at 2 times recommended rate at 48 hr by leaf dip method (Rvb = 20%)2011Pest management science, Jan, Volume: 67, Issue:1
Effect of reduced risk pesticides on greenhouse vegetable arthropod biological control agents.
AID1082923Insecticidal activity against Culex pipiens pallens (mosquito) fourth-instar larvae assessed as larvicidal activity at 2 mg/L measured 3 days post dose2012Journal of agricultural and food chemistry, Aug-08, Volume: 60, Issue:31
Synthesis and insecticidal activities of novel anthranilic diamides containing acylthiourea and acylurea.
AID1112813Insecticidal activity against Lissorhoptrus oryzophilus in rice plants assessed as leaf consumption rate per day at 50 ug treated as seed measured after 72 hr of feeding (Rvb = 8.3 +/- 0.7 mm'2 /day)2013Pest management science, Feb, Volume: 69, Issue:2
Systemic effects of thiamethoxam and chlorantraniliprole seed treatments on adult Lissorhoptrus oryzophilus (Coleoptera: Curculionidae) in rice.
AID323211Insecticidal activity against Aphis gossypii glover in cotton/melon plant2008Bioorganic & medicinal chemistry, Mar-15, Volume: 16, Issue:6
Synthesis of insecticidal fluorinated anthranilic diamides.
AID1104915Toxicity in Orius insidiosus infested green bean leaves assessed as mortality at recommended rate at 48 hr by leaf dip method (Rvb = 20%)2011Pest management science, Jan, Volume: 67, Issue:1
Effect of reduced risk pesticides on greenhouse vegetable arthropod biological control agents.
AID1112027Insecticidal activity against Drosophila suzukii assessed as mortality at 113.8 g/ha by direct application at 22 degC measured after 24 hr2011Pest management science, Nov, Volume: 67, Issue:11
Laboratory and field comparisons of insecticides to reduce infestation of Drosophila suzukii in berry crops.
AID1082910Inhibition of voltage-dependent L-type calcium channel in Spodoptera exigua neurons assessed as peak calcium current at 0.1 mM measured 8 min post dose by electrophysiology method (Rvb = 90.85 +/- 0.65%)2012Journal of agricultural and food chemistry, Aug-08, Volume: 60, Issue:31
Synthesis and insecticidal activities of novel anthranilic diamides containing acylthiourea and acylurea.
AID1112206Insecticidal activity against po dosed Cydia pomonella (codling moth) lab-s neonate measured after 4 days2012Pest management science, Jun, Volume: 68, Issue:6
Development of a rapid resistance monitoring bioassay for codling moth larvae.
AID323217Insecticidal activity against Myzus persicae Sulzer in raddish plant by systemic plant assay2008Bioorganic & medicinal chemistry, Mar-15, Volume: 16, Issue:6
Synthesis of insecticidal fluorinated anthranilic diamides.
AID1111850Insecticidal activity against Spodoptera exigua F22 neonate larvae assessed as mortality at 27 +/- 1 degC, 60 to 70% RH measured after 72 hr2011Pest management science, Nov, Volume: 67, Issue:11
Assessment of resistance risk in Spodoptera exigua (Hübner) (Lepidoptera: Noctuidae) to chlorantraniliprole.
AID1082892Insecticidal activity against Mythimna separata (Oriental armyworm) fourth-instar larvae infected Zea mays leaves assessed as larvicidal activity at 100 mg/L measured 2 days post dose2012Journal of agricultural and food chemistry, Aug-08, Volume: 60, Issue:31
Synthesis and insecticidal activities of novel anthranilic diamides containing acylthiourea and acylurea.
AID1112205Insecticidal activity against po dosed fourth-instar larvae of Cydia pomonella (codling moth) lab-s measured after 4 days2012Pest management science, Jun, Volume: 68, Issue:6
Development of a rapid resistance monitoring bioassay for codling moth larvae.
AID420816Selectivity for Heliothis virescens recombinant ryanodine receptor over ryanodine receptor 2 in rat PC12 cells2009Bioorganic & medicinal chemistry, Jun-15, Volume: 17, Issue:12
New and selective ryanodine receptor activators for insect control.
AID309999Selectivity for Drosophila melanogaster ryanodine receptor over mouse ryanodine receptor in C2C12 cells2007Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22
Rynaxypyr: a new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator.
AID323212Insecticidal activity against Myzus persicae Sulzer in raddish plant2008Bioorganic & medicinal chemistry, Mar-15, Volume: 16, Issue:6
Synthesis of insecticidal fluorinated anthranilic diamides.
AID1111779Insecticidal activity against adult female Dendroctonus ponderosae assessed as mortality applied topically to ventral surface of insect mesothorax after 24 hr2011Pest management science, May, Volume: 67, Issue:5
Laboratory assays of select candidate insecticides for control of Dendroctonus ponderosae.
AID420811Activation of ryanodine receptor 2 in rat PC12 cells assessed as induction of calcium mobilization2009Bioorganic & medicinal chemistry, Jun-15, Volume: 17, Issue:12
New and selective ryanodine receptor activators for insect control.
AID1082924Insecticidal activity against Culex pipiens pallens (mosquito) fourth-instar larvae assessed as larvicidal activity at 1 mg/L measured 3 days post dose2012Journal of agricultural and food chemistry, Aug-08, Volume: 60, Issue:31
Synthesis and insecticidal activities of novel anthranilic diamides containing acylthiourea and acylurea.
AID309992Activation of Heliothis virescens recombinant ryanodine receptor expressed in Sf9 cells assessed as induction of calcium mobilization2007Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22
Rynaxypyr: a new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator.
AID309996Activation of ryanodine receptor in rat PC12 cells assessed as induction of calcium mobilization at 100 uM2007Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22
Rynaxypyr: a new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator.
AID1112814Insecticidal activity against Lissorhoptrus oryzophilus in rice plants assessed as leaf consumption rate per day at 25 ug treated as seed measured after 72 hr of feeding (Rvb = 8.3 +/- 0.7 mm'2 /day)2013Pest management science, Feb, Volume: 69, Issue:2
Systemic effects of thiamethoxam and chlorantraniliprole seed treatments on adult Lissorhoptrus oryzophilus (Coleoptera: Curculionidae) in rice.
AID1083106Pesticidal activity against Aphis gossypii (cotton aphid) third-instar nymphae grown on tender Hibiscus syriacus leaves assessed as pest mortality at 200 mg/L measured 24 hr post compound exposure2012Journal of agricultural and food chemistry, Nov-07, Volume: 60, Issue:44
Synthesis and bioactivity study of 2-acylamino-substituted N'-benzylbenzohydrazide derivatives.
AID1082917Insecticidal activity against Plutella xylostella (diamondback moth) s-instar larvae infected in fresh cabbage leaves assessed as larvicidal activity at 0.001 mg/L measured 2 days post dose2012Journal of agricultural and food chemistry, Aug-08, Volume: 60, Issue:31
Synthesis and insecticidal activities of novel anthranilic diamides containing acylthiourea and acylurea.
AID1083109Pesticidal activity against Tetranychus cinnabarinus (carmine spider mite) third- instar larvae grown on Phaseolus vulgaris leaves assessed as pest mortality measured 48 hr post compound exposure2012Journal of agricultural and food chemistry, Nov-07, Volume: 60, Issue:44
Synthesis and bioactivity study of 2-acylamino-substituted N'-benzylbenzohydrazide derivatives.
AID310005Toxicity in rabbit above 1000 mg/kg/day2007Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22
Rynaxypyr: a new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator.
AID1092175Insecticidal activity against Culex pipiens pallens (mosquito) fourth-instar larvae assessed as mortality at 2 ug/mL measured 72 hr post compound treatment2012Molecules (Basel, Switzerland), Aug-31, Volume: 17, Issue:9
Synthesis, structure and insecticidal activities of some novel amides containing N-pyridylpyrazole moeities.
AID1092173Insecticidal activity against Plutella xylostella (diamondback moth) second-instar larvae infested on compound pre-treated cabbage leaves assessed as mortality at 100 ug/mL measured 3 days post compound treatment by leaf-dipping assay2012Molecules (Basel, Switzerland), Aug-31, Volume: 17, Issue:9
Synthesis, structure and insecticidal activities of some novel amides containing N-pyridylpyrazole moeities.
AID309994Activation of ryanodine receptor in mouse C2C12 cells assessed as induction of calcium mobilization2007Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22
Rynaxypyr: a new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator.
AID1110952Antifeedant activity against third-instar larval stage of Plutella xylostella (diamondback moth) infested compound-treated leaf assessed as reduction in feeding damage at 167 mg a.i/L after 48 hr by leaf disk assay relative to untreated control2009Pest management science, Sep, Volume: 65, Issue:9
Feeding cessation effects of chlorantraniliprole, a new anthranilic diamide insecticide, in comparison with several insecticides in distinct chemical classes and mode-of-action groups.
AID1112589Lipophilicity, log P of the compound2012Bioorganic & medicinal chemistry letters, Jun-01, Volume: 22, Issue:11
Novel diamide insecticides: sulfoximines, sulfonimidamides and other new sulfonimidoyl derivatives.
AID1083111Pesticidal activity against Tetranychus cinnabarinus (carmine spider mite) third- instar larvae grown on Phaseolus vulgaris leaves assessed as pest mortality at 100 mg/L measured 48 hr post compound exposure2012Journal of agricultural and food chemistry, Nov-07, Volume: 60, Issue:44
Synthesis and bioactivity study of 2-acylamino-substituted N'-benzylbenzohydrazide derivatives.
AID1081799Insecticidal activity against second-instar larval stage of Plutella xylostella (diamondback moth) in cabbage leaves assessed as mortality at 2.5 mg/l at 25 +/-1 degC treated for 3 secs before larva infestation measured after 2 days by leaf-dip method2010Journal of agricultural and food chemistry, Dec-08, Volume: 58, Issue:23
Synthesis and insecticidal activities of novel anthranilic diamides containing modified N-pyridylpyrazoles.
AID1110959Antifeedant activity against third-instar larval stage of Plutella xylostella (diamondback moth) infested compound-treated leaf assessed as time required to stop feeding at 167 mg a.i/L after 48 hr by leaf disk assay (Rvb = > 2880 min)2009Pest management science, Sep, Volume: 65, Issue:9
Feeding cessation effects of chlorantraniliprole, a new anthranilic diamide insecticide, in comparison with several insecticides in distinct chemical classes and mode-of-action groups.
AID1092170Insecticidal activity against Spodoptera exigua third-instar larvae infested on compound pre-treated cabbage leaves assessed as mortality at 200 ug/mL measured 3 days post compound treatment by leaf-dipping assay2012Molecules (Basel, Switzerland), Aug-31, Volume: 17, Issue:9
Synthesis, structure and insecticidal activities of some novel amides containing N-pyridylpyrazole moeities.
AID1092176Insecticidal activity against fourth-instar larvae of Mythimna separata (Oriental armyworm) reared on compound pre-treated corn leaves assessed as mortality at 5 ug/mL measured 72 hr post compound treatment by leaf-dipping assay2012Molecules (Basel, Switzerland), Aug-31, Volume: 17, Issue:9
Synthesis, structure and insecticidal activities of some novel amides containing N-pyridylpyrazole moeities.
AID1104911Toxicity in Eretmocerus eremicus infested green bean leaves assessed as mortality at recommended rate at 48 hr by leaf dip method (Rvb = 10%)2011Pest management science, Jan, Volume: 67, Issue:1
Effect of reduced risk pesticides on greenhouse vegetable arthropod biological control agents.
AID1111785Insecticidal activity against adult Dendroctonus ponderosae assessed as mortality after 12 hr by filter paper assay2011Pest management science, May, Volume: 67, Issue:5
Laboratory assays of select candidate insecticides for control of Dendroctonus ponderosae.
AID1112020Insecticidal activity against Drosophila suzukii assessed as male mortality at 3.31 g/ha by direct application at 22 degC measured after 24 hr2011Pest management science, Nov, Volume: 67, Issue:11
Laboratory and field comparisons of insecticides to reduce infestation of Drosophila suzukii in berry crops.
AID1081796Insecticidal activity against second-instar larval stage of Plutella xylostella (diamondback moth) in cabbage leaves assessed as mortality at 0.25 mg/l at 25 +/-1 degC treated for 3 secs before larva infestation measured after 2 days by leaf-dip method2010Journal of agricultural and food chemistry, Dec-08, Volume: 58, Issue:23
Synthesis and insecticidal activities of novel anthranilic diamides containing modified N-pyridylpyrazoles.
AID1092167Insecticidal activity against Spodoptera exigua third-instar larvae infested on compound pre-treated cabbage leaves assessed as mortality at 25 ug/mL measured 3 days post compound treatment by leaf-dipping assay2012Molecules (Basel, Switzerland), Aug-31, Volume: 17, Issue:9
Synthesis, structure and insecticidal activities of some novel amides containing N-pyridylpyrazole moeities.
AID1082894Inhibition of voltage-dependent L-type calcium channel in Spodoptera exigua neurons assessed as peak calcium current at 0.1 mM measured 1 min post dose by electrophysiology method (Rvb = 104.47 +/- 2.33%)2012Journal of agricultural and food chemistry, Aug-08, Volume: 60, Issue:31
Synthesis and insecticidal activities of novel anthranilic diamides containing acylthiourea and acylurea.
AID1112590Aqueous solubility of the compound at pH 72012Bioorganic & medicinal chemistry letters, Jun-01, Volume: 22, Issue:11
Novel diamide insecticides: sulfoximines, sulfonimidamides and other new sulfonimidoyl derivatives.
AID1081798Insecticidal activity against second-instar larval stage of Plutella xylostella (diamondback moth) in cabbage leaves assessed as mortality at 1 mg/l at 25 +/-1 degC treated for 3 secs before larva infestation measured after 2 days by leaf-dip method2010Journal of agricultural and food chemistry, Dec-08, Volume: 58, Issue:23
Synthesis and insecticidal activities of novel anthranilic diamides containing modified N-pyridylpyrazoles.
AID1110977Antifeedant activity against third-instar larval stage of Spodoptera exigua infested compound-treated leaf assessed as time required to stop feeding at 167 mg a.i/L after 48 hr by leaf disk assay (Rvb = > 2880 min)2009Pest management science, Sep, Volume: 65, Issue:9
Feeding cessation effects of chlorantraniliprole, a new anthranilic diamide insecticide, in comparison with several insecticides in distinct chemical classes and mode-of-action groups.
AID1112870Binding affinity to Myzus persicae (green peach aphid) ryanodine receptor by radioligand binding assay2013Pest management science, Jan, Volume: 69, Issue:1
The story of a new insecticidal chemistry class: the diamides.
AID1081808Insecticidal activity against fourth-instar larval stage of Mythimna separata (Oriental armyworm) in compound pretreated Zea mays L. Tangyu 10 leaves assessed as mortality at 100 mg/l at 25 +/-1 degC after 2 days2010Journal of agricultural and food chemistry, Dec-08, Volume: 58, Issue:23
Synthesis and insecticidal activities of novel anthranilic diamides containing modified N-pyridylpyrazoles.
AID1082890Insecticidal activity against Mythimna separata (Oriental armyworm) fourth-instar larvae infected Zea mays leaves assessed as larvicidal activity at 20 mg/L measured 2 days post dose2012Journal of agricultural and food chemistry, Aug-08, Volume: 60, Issue:31
Synthesis and insecticidal activities of novel anthranilic diamides containing acylthiourea and acylurea.
AID1082904Inhibition of voltage-dependent L-type calcium channel in Spodoptera exigua neurons assessed as peak intracellular calcium level at 1000 mg/L measured 10 min post dose by calcium-imaging technique relative to initial untreated control2012Journal of agricultural and food chemistry, Aug-08, Volume: 60, Issue:31
Synthesis and insecticidal activities of novel anthranilic diamides containing acylthiourea and acylurea.
AID1092166Insecticidal activity against fourth-instar larvae of Mythimna separata (Oriental armyworm) reared on compound pre-treated corn leaves assessed as induction of abnormal symptoms at 10 ug/mL measured 36 hr post compound treatment by leaf-dipping assay2012Molecules (Basel, Switzerland), Aug-31, Volume: 17, Issue:9
Synthesis, structure and insecticidal activities of some novel amides containing N-pyridylpyrazole moeities.
AID1111009Antifeedant activity against third-instar larval stage of Trichoplusia ni (cabbage looper) infested compound-treated leaf assessed as time required to stop feeding at 167 mg a.i/L after 48 hr by leaf disk assay (Rvb = > 2880 min)2009Pest management science, Sep, Volume: 65, Issue:9
Feeding cessation effects of chlorantraniliprole, a new anthranilic diamide insecticide, in comparison with several insecticides in distinct chemical classes and mode-of-action groups.
AID1082922Insecticidal activity against Culex pipiens pallens (mosquito) fourth-instar larvae assessed as larvicidal activity at 0.5 mg/L measured 3 days post dose2012Journal of agricultural and food chemistry, Aug-08, Volume: 60, Issue:31
Synthesis and insecticidal activities of novel anthranilic diamides containing acylthiourea and acylurea.
AID1112591Displacement of [3H]-Tritium-N-(4-chloro-2-methyl-6-(methylcarbamoyl)phenyl)-1-(3-chloropyridin-2-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide from Myzus persicae (green peach aphid) ryanodine receptor2012Bioorganic & medicinal chemistry letters, Jun-01, Volume: 22, Issue:11
Novel diamide insecticides: sulfoximines, sulfonimidamides and other new sulfonimidoyl derivatives.
AID1112823Insecticidal activity against Lissorhoptrus oryzophilus in rice plants assessed as mortality at 25 ug treated as seed measured after 72 hr of feeding (Rvb = 15 +/- 2.9%)2013Pest management science, Feb, Volume: 69, Issue:2
Systemic effects of thiamethoxam and chlorantraniliprole seed treatments on adult Lissorhoptrus oryzophilus (Coleoptera: Curculionidae) in rice.
AID1112582Insecticidal activity against Plutella xylostella (diamondback moth) assessed as mortality by greenhouse assay2012Bioorganic & medicinal chemistry letters, Jun-01, Volume: 22, Issue:11
Novel diamide insecticides: sulfoximines, sulfonimidamides and other new sulfonimidoyl derivatives.
AID1111849Resistance factor, LC50 for Spodoptera exigua F0 neonate larvae to LC50 for Spodoptera exigua SS neonate larvae2011Pest management science, Nov, Volume: 67, Issue:11
Assessment of resistance risk in Spodoptera exigua (Hübner) (Lepidoptera: Noctuidae) to chlorantraniliprole.
AID1092168Insecticidal activity against Spodoptera exigua third-instar larvae infested on compound pre-treated cabbage leaves assessed as mortality at 50 ug/mL measured 3 days post compound treatment by leaf-dipping assay2012Molecules (Basel, Switzerland), Aug-31, Volume: 17, Issue:9
Synthesis, structure and insecticidal activities of some novel amides containing N-pyridylpyrazole moeities.
AID1092174Insecticidal activity against Plutella xylostella (diamondback moth) second-instar larvae infested on compound pre-treated cabbage leaves assessed as mortality at 200 ug/mL measured 3 days post compound treatment by leaf-dipping assay2012Molecules (Basel, Switzerland), Aug-31, Volume: 17, Issue:9
Synthesis, structure and insecticidal activities of some novel amides containing N-pyridylpyrazole moeities.
AID1111780Insecticidal activity against adult male Dendroctonus ponderosae assessed as mortality after 24 hr by filter paper assay2011Pest management science, May, Volume: 67, Issue:5
Laboratory assays of select candidate insecticides for control of Dendroctonus ponderosae.
AID1111851Insecticidal activity against Spodoptera exigua F11 neonate larvae assessed as mortality at 27 +/- 1 degC, 60 to 70% RH measured after 72 hr2011Pest management science, Nov, Volume: 67, Issue:11
Assessment of resistance risk in Spodoptera exigua (Hübner) (Lepidoptera: Noctuidae) to chlorantraniliprole.
AID1111853Insecticidal activity against susceptible strain Spodoptera exigua SS neonate larvae assessed as mortality at 27 +/- 1 degC, 60 to 70% RH measured after 72 hr2011Pest management science, Nov, Volume: 67, Issue:11
Assessment of resistance risk in Spodoptera exigua (Hübner) (Lepidoptera: Noctuidae) to chlorantraniliprole.
AID1112021Insecticidal activity against Drosophila suzukii assessed as male mortality at 41 g/ha by direct application at 22 degC measured after 24 hr2011Pest management science, Nov, Volume: 67, Issue:11
Laboratory and field comparisons of insecticides to reduce infestation of Drosophila suzukii in berry crops.
AID309990Insecticidal activity against Plutella xylostella2007Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22
Rynaxypyr: a new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator.
AID1082893Insecticidal activity against Mythimna separata (Oriental armyworm) fourth-instar larvae infected Zea mays leaves assessed as larvicidal activity at 200 mg/L measured 2 days post dose2012Journal of agricultural and food chemistry, Aug-08, Volume: 60, Issue:31
Synthesis and insecticidal activities of novel anthranilic diamides containing acylthiourea and acylurea.
AID1081805Insecticidal activity against fourth-instar larval stage of Mythimna separata (Oriental armyworm) in compound pretreated Zea mays L. Tangyu 10 leaves assessed as mortality at 10 mg/l at 25 +/-1 degC after 2 days2010Journal of agricultural and food chemistry, Dec-08, Volume: 58, Issue:23
Synthesis and insecticidal activities of novel anthranilic diamides containing modified N-pyridylpyrazoles.
AID1082921Insecticidal activity against Plutella xylostella (diamondback moth) s-instar larvae infected in fresh cabbage leaves assessed as larvicidal activity at 20 mg/L measured 2 days post dose2012Journal of agricultural and food chemistry, Aug-08, Volume: 60, Issue:31
Synthesis and insecticidal activities of novel anthranilic diamides containing acylthiourea and acylurea.
AID1111784Insecticidal activity against adult Dendroctonus ponderosae assessed as mortality after 24 hr by filter paper assay2011Pest management science, May, Volume: 67, Issue:5
Laboratory assays of select candidate insecticides for control of Dendroctonus ponderosae.
AID1082925Insecticidal activity against Mythimna separata (Oriental armyworm) fourth-instar larvae infected Zea mays leaves assessed as larvicidal activity at 5 mg/L measured 2 days post dose2012Journal of agricultural and food chemistry, Aug-08, Volume: 60, Issue:31
Synthesis and insecticidal activities of novel anthranilic diamides containing acylthiourea and acylurea.
AID1082918Insecticidal activity against Plutella xylostella (diamondback moth) s-instar larvae infected in fresh cabbage leaves assessed as larvicidal activity at 0.01 mg/L measured 2 days post dose2012Journal of agricultural and food chemistry, Aug-08, Volume: 60, Issue:31
Synthesis and insecticidal activities of novel anthranilic diamides containing acylthiourea and acylurea.
AID310004Toxicity in rat above 1000 mg/kg/day2007Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22
Rynaxypyr: a new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator.
AID1112812Insecticidal activity against Lissorhoptrus oryzophilus in rice plants assessed as leaf consumption rate per day at 100 ug treated as seed measured after 72 hr of feeding (Rvb = 8.3 +/- 0.7 mm'2 /day)2013Pest management science, Feb, Volume: 69, Issue:2
Systemic effects of thiamethoxam and chlorantraniliprole seed treatments on adult Lissorhoptrus oryzophilus (Coleoptera: Curculionidae) in rice.
AID309997Activation of ryanodine receptor in human IMR32 cells assessed as induction of calcium mobilization2007Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22
Rynaxypyr: a new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator.
AID1082898Inhibition of voltage-dependent L-type calcium channel in Spodoptera exigua neurons assessed as peak calcium current at 0.1 mM measured 3 min post dose by electrophysiology method (Rvb = 101.76 +/- 2.7%)2012Journal of agricultural and food chemistry, Aug-08, Volume: 60, Issue:31
Synthesis and insecticidal activities of novel anthranilic diamides containing acylthiourea and acylurea.
AID1111782Insecticidal activity against adult Dendroctonus ponderosae assessed as mortality applied topically to ventral surface of insect mesothorax after 24 hr2011Pest management science, May, Volume: 67, Issue:5
Laboratory assays of select candidate insecticides for control of Dendroctonus ponderosae.
AID1092169Insecticidal activity against Spodoptera exigua third-instar larvae infested on compound pre-treated cabbage leaves assessed as mortality at 100 ug/mL measured 3 days post compound treatment by leaf-dipping assay2012Molecules (Basel, Switzerland), Aug-31, Volume: 17, Issue:9
Synthesis, structure and insecticidal activities of some novel amides containing N-pyridylpyrazole moeities.
AID1112822Insecticidal activity against Lissorhoptrus oryzophilus in rice plants assessed as mortality at 50 ug treated as seed measured after 72 hr of feeding (Rvb = 15 +/- 2.9%)2013Pest management science, Feb, Volume: 69, Issue:2
Systemic effects of thiamethoxam and chlorantraniliprole seed treatments on adult Lissorhoptrus oryzophilus (Coleoptera: Curculionidae) in rice.
AID1082912Inhibition of voltage-dependent L-type calcium channel in Spodoptera exigua neurons assessed as peak calcium current at 0.1 mM measured 5 min post dose by electrophysiology method (Rvb = 98.06 +/- 1.01%)2012Journal of agricultural and food chemistry, Aug-08, Volume: 60, Issue:31
Synthesis and insecticidal activities of novel anthranilic diamides containing acylthiourea and acylurea.
AID1112815Insecticidal activity against Lissorhoptrus oryzophilus in rice plants assessed as leaf consumption rate per day at 10 ug treated as seed measured after 72 hr of feeding (Rvb = 8.3 +/- 0.7 mm'2 /day)2013Pest management science, Feb, Volume: 69, Issue:2
Systemic effects of thiamethoxam and chlorantraniliprole seed treatments on adult Lissorhoptrus oryzophilus (Coleoptera: Curculionidae) in rice.
AID1081807Insecticidal activity against fourth-instar larval stage of Mythimna separata (Oriental armyworm) in compound pretreated Zea mays L. Tangyu 10 leaves assessed as mortality at 50 mg/l at 25 +/-1 degC after 2 days2010Journal of agricultural and food chemistry, Dec-08, Volume: 58, Issue:23
Synthesis and insecticidal activities of novel anthranilic diamides containing modified N-pyridylpyrazoles.
AID1081806Insecticidal activity against fourth-instar larval stage of Mythimna separata (Oriental armyworm) in compound pretreated Zea mays L. Tangyu 10 leaves assessed as mortality at 20 mg/l at 25 +/-1 degC after 2 days2010Journal of agricultural and food chemistry, Dec-08, Volume: 58, Issue:23
Synthesis and insecticidal activities of novel anthranilic diamides containing modified N-pyridylpyrazoles.
AID1081802Insecticidal activity against second-instar larval stage of Plutella xylostella (diamondback moth) in cabbage leaves assessed as mortality at 20 mg/l at 25 +/-1 degC treated for 3 secs before larva infestation measured after 2 days by leaf-dip method2010Journal of agricultural and food chemistry, Dec-08, Volume: 58, Issue:23
Synthesis and insecticidal activities of novel anthranilic diamides containing modified N-pyridylpyrazoles.
AID1081795Insecticidal activity against second-instar larval stage of Plutella xylostella (diamondback moth) in cabbage leaves assessed as mortality at 0.125 mg/l at 25 +/-1 degC treated for 3 secs before larva infestation measured after 2 days by leaf-dip method2010Journal of agricultural and food chemistry, Dec-08, Volume: 58, Issue:23
Synthesis and insecticidal activities of novel anthranilic diamides containing modified N-pyridylpyrazoles.
AID1111783Insecticidal activity against adult Dendroctonus ponderosae assessed as mortality applied topically on the ventral surface of insect mesothorax after 12 hr2011Pest management science, May, Volume: 67, Issue:5
Laboratory assays of select candidate insecticides for control of Dendroctonus ponderosae.
AID1592378Insecticidal activity against Mythimna separata assessed as larval mortality at 10 mg/l by leaf-dip method2019European journal of medicinal chemistry, Apr-01, Volume: 167Chemical synthesis, crystal structure, versatile evaluation of their biological activities and molecular simulations of novel pyrithiobac derivatives.
AID1111845Resistance factor, LC50 for Spodoptera exigua F22 neonate larvae to LC50 for Spodoptera exigua F0 neonate larvae2011Pest management science, Nov, Volume: 67, Issue:11
Assessment of resistance risk in Spodoptera exigua (Hübner) (Lepidoptera: Noctuidae) to chlorantraniliprole.
AID310001Selectivity for Drosophila melanogaster ryanodine receptor over rat ryanodine receptor in PC12 cells2007Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22
Rynaxypyr: a new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator.
AID420810Activation of ryanodine receptor 1 in mouse C2C12 cells assessed as induction of calcium mobilization2009Bioorganic & medicinal chemistry, Jun-15, Volume: 17, Issue:12
New and selective ryanodine receptor activators for insect control.
AID1111781Insecticidal activity against adult female Dendroctonus ponderosae assessed as mortality after 24 hr by filter paper assay2011Pest management science, May, Volume: 67, Issue:5
Laboratory assays of select candidate insecticides for control of Dendroctonus ponderosae.
AID310003Toxicity in po dosed rat2007Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22
Rynaxypyr: a new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator.
AID1112592Displacement of [3H]-Tritium-N-(4-chloro-2-methyl-6-(methylcarbamoyl)phenyl)-1-(3-chloropyridin-2-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide from Spodoptera littoralis ryanodine receptor2012Bioorganic & medicinal chemistry letters, Jun-01, Volume: 22, Issue:11
Novel diamide insecticides: sulfoximines, sulfonimidamides and other new sulfonimidoyl derivatives.
AID1083112Pesticidal activity against Tetranychus cinnabarinus (carmine spider mite) third- instar larvae grown on Phaseolus vulgaris leaves assessed as pest mortality at 400 mg/L measured 48 hr post compound exposure2012Journal of agricultural and food chemistry, Nov-07, Volume: 60, Issue:44
Synthesis and bioactivity study of 2-acylamino-substituted N'-benzylbenzohydrazide derivatives.
AID420809Activation of Drosophila melanogaster ryanodine receptor assessed as induction of calcium mobilization2009Bioorganic & medicinal chemistry, Jun-15, Volume: 17, Issue:12
New and selective ryanodine receptor activators for insect control.
AID310000Selectivity for Heliothis virescens recombinant ryanodine receptor over mouse ryanodine receptor in C2C12 cells2007Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22
Rynaxypyr: a new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator.
AID420805Insecticidal activity against Heliothis virescens larvae2009Bioorganic & medicinal chemistry, Jun-15, Volume: 17, Issue:12
New and selective ryanodine receptor activators for insect control.
AID420815Selectivity for Drosophila melanogaster ryanodine receptor over ryanodine receptor 2 in rat PC12 cells2009Bioorganic & medicinal chemistry, Jun-15, Volume: 17, Issue:12
New and selective ryanodine receptor activators for insect control.
AID1082916Inhibition of voltage-dependent L-type calcium channel in Spodoptera exigua neurons assessed as peak calcium current at 0.1 mM measured 10 min post dose by electrophysiology method (Rvb = 85.44 +/- 1.14%)2012Journal of agricultural and food chemistry, Aug-08, Volume: 60, Issue:31
Synthesis and insecticidal activities of novel anthranilic diamides containing acylthiourea and acylurea.
AID1110993Antifeedant activity against third-instar larval stage of Helicoverpa zea (corn earworm) infested compound-treated leaf assessed as reduction in feeding damage at 167 mg a.i/L after 48 hr by leaf disk assay relative to untreated control2009Pest management science, Sep, Volume: 65, Issue:9
Feeding cessation effects of chlorantraniliprole, a new anthranilic diamide insecticide, in comparison with several insecticides in distinct chemical classes and mode-of-action groups.
AID420803Insecticidal activity against Spodoptera frugiperda larvae2009Bioorganic & medicinal chemistry, Jun-15, Volume: 17, Issue:12
New and selective ryanodine receptor activators for insect control.
AID1112821Insecticidal activity against Lissorhoptrus oryzophilus in rice plants assessed as mortality at 100 ug treated as seed measured after 72 hr of feeding (Rvb = 15 +/- 2.9%)2013Pest management science, Feb, Volume: 69, Issue:2
Systemic effects of thiamethoxam and chlorantraniliprole seed treatments on adult Lissorhoptrus oryzophilus (Coleoptera: Curculionidae) in rice.
AID1083115Pesticidal activity against Tetranychus cinnabarinus (carmine spider mite) third- instar larvae grown on Phaseolus vulgaris leaves assessed as pest mortality at 200 mg/L measured 48 hr post compound exposure2012Journal of agricultural and food chemistry, Nov-07, Volume: 60, Issue:44
Synthesis and bioactivity study of 2-acylamino-substituted N'-benzylbenzohydrazide derivatives.
AID1111847Resistance factor, LC50 for Spodoptera exigua F22 neonate larvae to LC50 for Spodoptera exigua SS neonate larvae2011Pest management science, Nov, Volume: 67, Issue:11
Assessment of resistance risk in Spodoptera exigua (Hübner) (Lepidoptera: Noctuidae) to chlorantraniliprole.
AID420814Selectivity for Heliothis virescens recombinant ryanodine receptor over ryanodine receptor 1 in mouse C2C12 cells2009Bioorganic & medicinal chemistry, Jun-15, Volume: 17, Issue:12
New and selective ryanodine receptor activators for insect control.
AID1112022Insecticidal activity against Drosophila suzukii assessed as male mortality at 112.3 g/ha by direct application at 22 degC measured after 24 hr2011Pest management science, Nov, Volume: 67, Issue:11
Laboratory and field comparisons of insecticides to reduce infestation of Drosophila suzukii in berry crops.
AID1112896Displacement of [3H]-methyl-SFX from nAChR in Myzus persicae (green peach aphid) 4106A membrane at 1 ppm after 70 min2013Pest management science, May, Volume: 69, Issue:5
Investigating the mode of action of sulfoxaflor: a fourth-generation neonicotinoid.
AID420813Selectivity for Drosophila melanogaster ryanodine receptor over ryanodine receptor 1 in mouse C2C12 cells2009Bioorganic & medicinal chemistry, Jun-15, Volume: 17, Issue:12
New and selective ryanodine receptor activators for insect control.
AID310002Selectivity for Heliothis virescens recombinant ryanodine receptor over rat ryanodine receptor in PC12 cells2007Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22
Rynaxypyr: a new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator.
AID1092171Insecticidal activity against Plutella xylostella (diamondback moth) second-instar larvae infested on compound pre-treated cabbage leaves assessed as mortality at 25 ug/mL measured 3 days post compound treatment by leaf-dipping assay2012Molecules (Basel, Switzerland), Aug-31, Volume: 17, Issue:9
Synthesis, structure and insecticidal activities of some novel amides containing N-pyridylpyrazole moeities.
AID1111778Insecticidal activity against adult male Dendroctonus ponderosae assessed as mortality applied topically to ventral surface of insect mesothorax after 24 hr2011Pest management science, May, Volume: 67, Issue:5
Laboratory assays of select candidate insecticides for control of Dendroctonus ponderosae.
AID323213Insecticidal activity against Myzus persicae Sulzer in raddish plant assessed as mortality at 250 ppm by systemic plant assay2008Bioorganic & medicinal chemistry, Mar-15, Volume: 16, Issue:6
Synthesis of insecticidal fluorinated anthranilic diamides.
AID1110967Antifeedant activity against third-instar larval stage of Trichoplusia ni (cabbage looper) infested compound-treated leaf assessed as reduction in feeding damage at 167 mg a.i/L after 48 hr by leaf disk assay relative to untreated control2009Pest management science, Sep, Volume: 65, Issue:9
Feeding cessation effects of chlorantraniliprole, a new anthranilic diamide insecticide, in comparison with several insecticides in distinct chemical classes and mode-of-action groups.
AID1112581Insecticidal activity against Myzus persicae (green peach aphid) assessed as mortality by greenhouse assay2012Bioorganic & medicinal chemistry letters, Jun-01, Volume: 22, Issue:11
Novel diamide insecticides: sulfoximines, sulfonimidamides and other new sulfonimidoyl derivatives.
AID1104912Toxicity in Typhlodromips swirskii infested green bean leaves assessed as mortality at recommended rate at 48 hr by leaf dip method (Rvb = 10%)2011Pest management science, Jan, Volume: 67, Issue:1
Effect of reduced risk pesticides on greenhouse vegetable arthropod biological control agents.
AID1111852Insecticidal activity against Spodoptera exigua F0 neonate larvae assessed as mortality at 27 +/- 1 degC, 60 to 70% RH measured after 72 hr2011Pest management science, Nov, Volume: 67, Issue:11
Assessment of resistance risk in Spodoptera exigua (Hübner) (Lepidoptera: Noctuidae) to chlorantraniliprole.
AID309995Activation of ryanodine receptor in rat PC12 cells assessed as induction of calcium mobilization2007Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22
Rynaxypyr: a new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator.
AID1110985Antifeedant activity against third-instar larval stage of Spodoptera exigua infested compound-treated leaf assessed as reduction in feeding damage at 167 mg a.i/L after 48 hr by leaf disk assay relative to untreated control2009Pest management science, Sep, Volume: 65, Issue:9
Feeding cessation effects of chlorantraniliprole, a new anthranilic diamide insecticide, in comparison with several insecticides in distinct chemical classes and mode-of-action groups.
AID309993Activation of Drosophila melanogaster ryanodine receptor in Sf9 cells assessed as induction of calcium mobilization2007Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22
Rynaxypyr: a new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator.
AID1081809Insecticidal activity against fourth-instar larval stage of Mythimna separata (Oriental armyworm) in compound pretreated Zea mays L. Tangyu 10 leaves assessed as mortality at 200 mg/l at 25 +/-1 degC after 2 days2010Journal of agricultural and food chemistry, Dec-08, Volume: 58, Issue:23
Synthesis and insecticidal activities of novel anthranilic diamides containing modified N-pyridylpyrazoles.
AID1111846Resistance factor, LC50 for Spodoptera exigua F11 neonate larvae to LC50 for Spodoptera exigua F0 neonate larvae2011Pest management science, Nov, Volume: 67, Issue:11
Assessment of resistance risk in Spodoptera exigua (Hübner) (Lepidoptera: Noctuidae) to chlorantraniliprole.
AID1104913Toxicity in Typhlodromips swirskii infested green bean leaves assessed as mortality at 2 times recommended rate at 48 hr by leaf dip method (Rvb = 10%)2011Pest management science, Jan, Volume: 67, Issue:1
Effect of reduced risk pesticides on greenhouse vegetable arthropod biological control agents.
AID420804Insecticidal activity against Plutella xylostella larvae2009Bioorganic & medicinal chemistry, Jun-15, Volume: 17, Issue:12
New and selective ryanodine receptor activators for insect control.
AID1111001Antifeedant activity against third-instar larval stage of Helicoverpa zea (corn earworm) infested compound-treated leaf assessed as time required to stop feeding at 167 mg a.i/L after 48 hr by leaf disk assay (Rvb = > 2880 min)2009Pest management science, Sep, Volume: 65, Issue:9
Feeding cessation effects of chlorantraniliprole, a new anthranilic diamide insecticide, in comparison with several insecticides in distinct chemical classes and mode-of-action groups.
AID323215Insecticidal activity against Aphis gossypii glover in cotton/melon plant by systemic plant assay2008Bioorganic & medicinal chemistry, Mar-15, Volume: 16, Issue:6
Synthesis of insecticidal fluorinated anthranilic diamides.
AID1104910Toxicity in Eretmocerus eremicus infested green bean leaves assessed as mortality at 2 times of recommended rate at 48 hr by leaf dip method (Rvb = 10%)2011Pest management science, Jan, Volume: 67, Issue:1
Effect of reduced risk pesticides on greenhouse vegetable arthropod biological control agents.
AID1082891Insecticidal activity against Mythimna separata (Oriental armyworm) fourth-instar larvae infected Zea mays leaves assessed as larvicidal activity at 50 mg/L measured 2 days post dose2012Journal of agricultural and food chemistry, Aug-08, Volume: 60, Issue:31
Synthesis and insecticidal activities of novel anthranilic diamides containing acylthiourea and acylurea.
AID1112583Insecticidal activity against Spodoptera littoralis assessed as mortality by greenhouse assay2012Bioorganic & medicinal chemistry letters, Jun-01, Volume: 22, Issue:11
Novel diamide insecticides: sulfoximines, sulfonimidamides and other new sulfonimidoyl derivatives.
AID1081797Insecticidal activity against second-instar larval stage of Plutella xylostella (diamondback moth) in cabbage leaves assessed as mortality at 0.5 mg/l at 25 +/-1 degC treated for 3 secs before larva infestation measured after 2 days by leaf-dip method2010Journal of agricultural and food chemistry, Dec-08, Volume: 58, Issue:23
Synthesis and insecticidal activities of novel anthranilic diamides containing modified N-pyridylpyrazoles.
AID420802Octanol-water partition coefficient, log P at 20 degC2009Bioorganic & medicinal chemistry, Jun-15, Volume: 17, Issue:12
New and selective ryanodine receptor activators for insect control.
AID323216Insecticidal activity against Myzus persicae Sulzer in raddish plant by contact plant assay2008Bioorganic & medicinal chemistry, Mar-15, Volume: 16, Issue:6
Synthesis of insecticidal fluorinated anthranilic diamides.
AID1081804Insecticidal activity against fourth-instar larval stage of Mythimna separata (Oriental armyworm) in compound pretreated Zea mays L. Tangyu 10 leaves assessed as mortality at 5 mg/l at 25 +/-1 degC after 2 days2010Journal of agricultural and food chemistry, Dec-08, Volume: 58, Issue:23
Synthesis and insecticidal activities of novel anthranilic diamides containing modified N-pyridylpyrazoles.
AID420807Activation of ryanodine receptor in Periplaneta americana neurons2009Bioorganic & medicinal chemistry, Jun-15, Volume: 17, Issue:12
New and selective ryanodine receptor activators for insect control.
AID1112023Insecticidal activity against Drosophila suzukii assessed as male mortality at 2.3 g/ha by direct application at 22 degC measured after 24 hr2011Pest management science, Nov, Volume: 67, Issue:11
Laboratory and field comparisons of insecticides to reduce infestation of Drosophila suzukii in berry crops.
AID1083113Pesticidal activity against Plutella xylostella (diamondback moth) second-instar larvae grown on cruciferous vegetables leaves leaves as pest mortality at 0.2 mg/L measured 48 hr post compound exposure2012Journal of agricultural and food chemistry, Nov-07, Volume: 60, Issue:44
Synthesis and bioactivity study of 2-acylamino-substituted N'-benzylbenzohydrazide derivatives.
AID1112824Insecticidal activity against Lissorhoptrus oryzophilus in rice plants assessed as mortality at 10 ug treated as seed measured after 72 hr of feeding (Rvb = 15 +/- 2.9%)2013Pest management science, Feb, Volume: 69, Issue:2
Systemic effects of thiamethoxam and chlorantraniliprole seed treatments on adult Lissorhoptrus oryzophilus (Coleoptera: Curculionidae) in rice.
AID309998Activation of ryanodine receptor in human IMR32 cells assessed as induction of calcium mobilization at 100 uM2007Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22
Rynaxypyr: a new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator.
AID323214Insecticidal activity against Aphis gossypii glover in cotton/melon plant by contact plant assay2008Bioorganic & medicinal chemistry, Mar-15, Volume: 16, Issue:6
Synthesis of insecticidal fluorinated anthranilic diamides.
AID1092172Insecticidal activity against Plutella xylostella (diamondback moth) second-instar larvae infested on compound pre-treated cabbage leaves assessed as mortality at 50 ug/mL measured 3 days post compound treatment by leaf-dipping assay2012Molecules (Basel, Switzerland), Aug-31, Volume: 17, Issue:9
Synthesis, structure and insecticidal activities of some novel amides containing N-pyridylpyrazole moeities.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (353)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's11 (3.12)29.6817
2010's216 (61.19)24.3611
2020's126 (35.69)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews6 (1.69%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other350 (98.31%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]