Conditions > Cataleptic Attacks
Page last updated: 2024-09-28

Cataleptic Attacks

A condition characterized by transient weakness or paralysis of somatic musculature triggered by an emotional stimulus or physical exertion. Cataplexy is frequently associated with NARCOLEPSY. During a cataplectic attack, there is a marked reduction in muscle tone similar to the normal physiologic hypotonia that accompanies rapid eye movement sleep (SLEEP, REM). (From Adams et al., Principles of Neurology, 6th ed, p396)

Synonyms(5)

Synonym
Tonelessness Syndrome
Status Cataplexicus
Henneberg Syndrome
Cataplexy
Cataleptic Attacks

Research Excerpts

Overview

ExcerptReference
"Cataplexy is the abrupt loss of muscle tone experienced by narcoleptics."( Cave, G; Dement, WC; Fahringer, H; Kilduff, T; Siegel, JM; Tomaszewski, KS, 1989)
"Cataplexy is usually controlled by tricyclic antidepressants, but these drugs interact with several central monoamine systems and also exert an anticholinergic effect."( Godbout, R; Montplaisir, J, 1986)
"Thus, experimental cataplexy is suppressed more by inhibition of the uptake of NE than of 5-HT."( Delashaw, JB; Dement, WC; Foutz, AS; Guilleminault, C, 1981)
"Cataplexy is a cardinal manifestation of the narcolepsy syndrome."( D'Cruz, OF; Gold, SH; Greenwood, RS; Vaughn, BV, 1994)
"Cataplexy is a common symptom associated with narcolepsy."( D'Cruz, OF; Vaughn, BV, 1996)
"Cataplexy is an ancillary symptom of narcolepsy and also occurs in multiple sclerosis (MS)."( Sandyk, R, 1995)
"The improvements in cataplexy are dependent on the dosage of sodium oxybate as well on the duration of treatment."( , 2005)
"The presence of cataplexy is strongly associated with a deficiency of the neuropeptide hypocretin."( Fronczek, R; Lammers, GJ; Overeem, S; van der Zande, WL; van Dijk, JG, 2007)
"Cataplexy is managed by medications whereas behavioral treatment, such as avoidance of emotion, was the only treatment available in the past."( Thorpy, M, 2007)
"Narcolepsy with cataplexy is a chronic neuropsychiatric disorder associated with inappropriate control of rapid eye movement (REM) sleep."( Møller, LR; Østergaard, JR, 2009)
"Cataplexy is the sudden muscle weakness brought on by strong emotions, particularly joking, laughter, or anger."( Dvorakova, L; Gurda, B; Kothare, SV; Steinborn, B; Vlaskova, H; Zarowski, M, 2011)
"We found that cataplexy is modulated by a D2-like receptor mechanism, whereas dopamine modulates sleep attacks by a D1-like receptor mechanism."( Burgess, CR; Gillis, L; Peever, JH; Tse, G, 2010)
"Narcolepsy with cataplexy is a rare disabling sleep disorder characterized by two major symptoms: excessive daytime sleepiness and cataplexy characterized by a sudden bilateral loss of voluntary muscular tone triggered by strong positive emotional factors."( Dauvilliers, Y; Lopez, R, 2013)
"Narcolepsy with cataplexy is rare in children under 5 years of age."( Ratkiewicz, M; Splaingard, M, 2013)
"Cataplexy is by far the most predictive feature of narcolepsy."( Panda, S, 2014)
"Narcolepsy with cataplexy is caused by a deficiency in the production of hypocretin/orexin, which regulates sleep and wakefulness, and also influences appetite, neuroendocrine functions and metabolism."( Keckeis, M; Kemlink, D; Lattová, Z; Maurovich-Horvat, E; Pollmächer, T; Schuld, A; Sonka, K; Wetter, TC, 2014)
"Cataplexy is a brief episode of bilateral loss of muscle tone with intact consciousness, triggered by a variety of strong emotions such as anger, laugh, humor or surprise and it is considered to represent the physiologic atonia of rapid eye movement sleep."( Cak, HT; Düzgün, G; Haliloğlu, G; Topçu, M; Yüce, A, 2014)
"Narcolepsy with cataplexy is most commonly caused by an immune-mediated process including genetic and environmental factors, resulting in the selective loss of hypocretin-producing neurons."( Bassetti, CL; Kallweit, U, 2017)
"Cataplexy is the sudden loss of muscle tone in either the face, neck, trunk, and/or limbs, leading to a loss of voluntary muscle control."( Murray, BJ; Narang, I; Parmar, A, 2020)
"Cataplexy is usually alleviated by antidepressants sodium oxybate and pitolisant."( Arnulf, I; Leu-Semenescu, S; Nigam, M, 2021)
"Cataplexy is classically considered to be an abnormal manifestation of REM sleep and is treated by selective serotonin (5HT) reuptake inhibitors."( Li, S; Possovre, ML; Seifinejad, A; Tafti, M; Vassalli, A, 2020)
"Cataplexy is one of the symptoms of type 1 narcolepsy, characterized by a sudden loss of muscle tone."( Hao, L; Kawashima, S; Kusumoto-Yoshida, I; Kuwaki, T; Lou, F, 2023)

Context

ExcerptReference
"The management of cataplexy has evolved over the past few years with the widespread use of antidepressants, especially those with adrenergic uptake inhibitor properties and gamma-hydroxybutyrate (sodium oxybate)."( Dauvilliers, Y; Lopez, R, 2013)

Treatment

ExcerptReference
"Sixteen patients with narcolepsy and cataplexy were treated with gamma-hydroxybutyrate (GHB) given at night and tailored to achieve as continuous a night's sleep as possible."( Broughton, R; Mamelak, M, 1979)
"Four narcoleptic dogs with cataplexy were given trials with the serotonin uptake blockers imipramine and chlorimipramine (known to be effective in treating cataplexy in humans)."( Babcock, DA; Dement, WC; Mitler, MM; Narver, EL, 1976)
"Both rapid eye movement sleep and cataplexy in the narcoleptic canine have been shown to increase after both systemic and local administration of cholinergic agonists in the pontine reticular formation."( Dement, WC; Mignot, E; Nishino, S; Reid, MS; Siegel, JM; Tafti, M, 1994)
"The improvements in cataplexy are dependent on the dosage of sodium oxybate as well on the duration of treatment."( , 2005)
"For treating cataplexy, the most widely used medications include the antidepressants venlafaxine, imipramine, and protriptyline, usually at lower doses than prescribed with depression, and sodium oxybate."( Roth, T, 2007)
"A third patient with partial cataplexy was treated with 75 mg of venlafaxine daily."( Møller, LR; Østergaard, JR, 2009)
"Weekly cataplexy attacks and Epworth Sleepiness Scale can be used to help document clinical response to narcolepsy treatment using criteria of 46% and 12% reductions, respectively."( Lai, C; Steffen, AD; Weaver, TE, 2018)
"Morphine administration also decreased cataplexy in mice made narcoleptic by the depletion of hypocretin neurons."( Chew, KT; Cornford, M; Fronczek, R; Inutsuka, A; John, J; Lammers, GJ; McGregor, R; Ramanathan, L; Shan, L; Siegel, JM; Swaab, DF; Thannickal, TC; Worley, PF; Wu, MF; Yamanaka, A, 2018)
"First-line treatment options for cataplexy include sodium oxybate and pitolisant, with many drugs such as AXS-12, FT218, and JZP258 under investigation."( Murray, BJ; Narang, I; Parmar, A, 2020)
"Its treatment aims to reduce EDS and cataplexy, improve nighttime sleep disturbance, sleep paralysis and sleep-related hallucinations."( Lou, G; Wang, T; Xu, Q; Zhang, L, 2020)
"Efficacy of LXB for the treatment of cataplexy and excessive daytime sleepiness was demonstrated."( Bogan, RK; Dauvilliers, Y; Del Rio Villegas, R; Foldvary-Schaefer, N; Partinen, M; Skobieranda, F; Skowronski, R; Šonka, K; Tang, L; Thorpy, MJ, 2021)
"Treatment response was defined for cataplexy as a ≥ 25%, ≥ 50%, or ≥ 75% reduction in weekly rate of cataplexy."( Davis, CW; Dayno, JM; Doliba, M; Meskill, GJ; Schwartz, JC; Zarycranski, D, 2022)
"LXB treats daytime sleepiness and cataplexy (sudden muscle weakness)."( Bogan, RK; Chen, A; Foldvary-Schaefer, N; Skowronski, R; Thorpy, MJ, 2023)

Research

Studies (355)

TimeframeStudies, This Condition (%)All Conditions %
pre-199088 (24.79)23.3326
1990's43 (12.11)12.5806
2000's86 (24.23)18.1394
2010's87 (24.51)28.8240
2020's51 (14.37)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0low70
5-hydroxytryptophan0medium21
carbamates0medium21
choline0low10
3,4-dihydroxyphenylacetic acid0low10
creatine0low30
glycine0low20
hydrogen carbonate0low10
histamine0low110
dihydroxyphenylalanine0low10
inositol0low20
melatonin0low30
urea0low20
7-hydroxy-2-n,n-dipropylaminotetralin0low30
sk&f 829580low10
sk&f-383930low10
1,3-dipropyl-8-cyclopentylxanthine0low10
4-diphenylacetoxy-1,1-dimethylpiperidinium0low10
homovanillic acid0low20
hydroxyindoleacetic acid0low10
theophylline0low10
baclofen0medium11
carbamazepine0low20
chlorpromazine0low10
citalopram0low10
clomipramine0low200
clonazepam0low30
clonidine0low10
desipramine0low20
amphetamine0medium151
donepezil0low10
fluoxetine0low70
flurazepam0low10
haloperidol0low70
tele-methylhistamine0low10
phenelzine0medium11
imipramine0medium251
ketamine0low10
ketoconazole0low10
lamotrigine0low10
lorazepam0low10
loxapine0low10
maprotiline0low10
mazindol0medium41
mecamylamine0low10
methylphenidate0medium311
modafinil0medium394
muscimol0low20
apnea0low40
neostigmine0low20
nisoxetine0low10
nortriptyline0low10
oxotremorine0low20
pemoline0medium31
phenacemide0low10
phenmetrazine0low30
phenoxybenzamine0low10
pirenzepine0low10
prazosin0low100
propranolol0low50
protriptyline0low40
pyrimethamine0low10
risperidone0low20
sulfadiazine0low10
sulpiride0low10
talipexole0low30
thalidomide0low10
thioridazine0low10
thiothixene0low10
trifluoperazine0low10
viloxazine0low10
wb 41010low10
prednisolone0low20
estriol0low10
lysergic acid diethylamide0low10
reserpine0low10
thyroxine0low10
dextroamphetamine0medium112
carbachol0low60
androsterone0low10
etiocholanolone0low10
dehydroepiandrosterone0low10
pentylenetetrazole0low10
triiodothyronine0low10
(4-(m-chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium chloride0low10
aspartic acid0low50
glutamine0low10
physostigmine0low80
apomorphine0low10
phenylephrine0low10
levodopa0low30
phenylethyl alcohol0low10
tyrosine0medium31
methoxamine0low10
methionine0low10
phenylalanine0medium31
gallamine triethiodide0low10
cyclohexanol0low90
yohimbine0low20
quinazolines0low10
benzoxazoles0low10
methysergide0low30
4-hydroxybutyric acid0low30
methamphetamine0medium41
s,n,n'-tripropylthiocarbamate0low20
pimozide0low10
tranylcypromine0low20
selegiline0low30
1-deoxynojirimycin0low40
glutamic acid0low10
tramadol0low10
zidovudine0low10
paroxetine0low10
fomesafen0low30
miglustat0low40
quinpirole0low40
atomoxetine hydrochloride0low10
eticlopride0low10
adenosine0low10
venlafaxine hydrochloride0low110
n-acetylaspartic acid0low40
4-nitrobenzylthioinosine0low10
triazoles0low10
fluorodeoxyglucose f180low20
nicotine0low20
pregnanetriol0low10
chlorethylclonidine0low10
ta 09100low10
reboxetine0low30
sdz nvi-0850low10
atropine0low60
tropatepine0low10
benzofurans0low10
adenosine-5'-(n-ethylcarboxamide)0low10
enkephalin, leucine0low10
physostigmine salicylate0low10
thioinosine0low10
enclomiphene0low10
D-fructopyranose0low10
thiopental0low10
femoxetine0low10
raclopride0low10
thioperamide0low10
sch 233900low10
rasagiline0low10
dinoprostone0low10
11-cis-retinal0low10
oxycodone0low10
topiramate0low10
morphine0low10
fluvoxamine0low30
zimeldine0low20
prostaglandin e2 methyl ester0low10
cysteine0low10
heroin0low10
tetrodotoxin0low10
ciproxifan0low10
pregnanediol0low10
sb 334867-a0low10
ergoline0low10
tiapamil hydrochloride0low10
montirelin0low10
benzonitrile, 4-(2-(2-((2r)-2-methyl-1-pyrrolidinyl)ethyl)-5-benzofuranyl)-0low10
pitolisant0medium196
scopolamine hydrobromide0low10
jaw0low10
oligonucleotides0low10
sodium oxybate0medium9722
almorexant0low10
suvorexant0low10
cardiovascular agents0low10
piperidines0medium225
interleukin-80low10
orexin-a0low10
clozapine0low60
guanylyl imidodiphosphate0low10
cholestyramine resin0low10
technetium tc 99m bicisate0low10
leptin0low30

Protein Targets (1,352)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
endonuclease IV8008
thioredoxin reductase470047
aldehyde dehydrogenase 1 family, member A1290029
euchromatic histone-lysine N-methyltransferase 2700070
Bloom syndrome protein isoform 1200020
lamin isoform A-delta10430043
Muscarinic acetylcholine receptor M2033744
Muscarinic acetylcholine receptor M4029638
Muscarinic acetylcholine receptor M5030538
Muscarinic acetylcholine receptor M1034847
Muscarinic acetylcholine receptor M3032742
Muscarinic acetylcholine receptor0718
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE280028
glucocerebrosidase9009
Alpha-mannosidase0101
alpha-galactosidase4004
Trehalase 0202
lysosomal alpha-glucosidase preproprotein5005
Trehalase0101
Maltase-glucoamylase, intestinal0202
Trehalase 0202
Lysosomal acid glucosylceramidase0404
Alpha-galactosidase A0101
Alpha-glucosidase MAL620101
Lactase-phlorizin hydrolase0202
Lysosomal alpha-glucosidase0404
Beta-glucosidase A0101
Sucrase-isomaltase, intestinal0202
Alpha-1B adrenergic receptor031536
Sucrase-isomaltase, intestinal0202
Alpha-1D adrenergic receptor028534
Beta-glucosidase0101
Protein-lysine 6-oxidase0404
Alpha-mannosidase 20202
Glycogen debranching enzyme0202
Glycogen debranching enzyme0101
Alpha-glucosidase MAL320101
Alpha-1A adrenergic receptor034640
Oligo-1,6-glucosidase IMA10101
Alpha-glucosidase MAL120202
Oxysterols receptor LXR-beta0101
Spike glycoprotein251228
Alpha-amylase 0101
Trehalose synthase/amylase TreS0101
Lactase-phlorizin hydrolase 0202
Oxysterols receptor LXR-alpha0101
Neutral alpha-glucosidase AB0202
Ceramide glucosyltransferase0202
Lysosomal acid glucosylceramidase0101
Probable maltase-glucoamylase 20101
Beta-glucosidase 0101
Lysosomal alpha-glucosidase0303
Cytosolic beta-glucosidase0101
Non-lysosomal glucosylceramidase0202
Putative alpha-glucosidase0202
ATAD5 protein, partial270027
TDP1 protein580058
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)120012
thyroid stimulating hormone receptor260026
estrogen-related nuclear receptor alpha380038
67.9K protein120012
peripheral myelin protein 22 isoform 1120012
chromobox protein homolog 1360036
nuclear factor erythroid 2-related factor 2 isoform 2100010
DNA polymerase iota isoform a (long)130013
nuclear receptor ROR-gamma isoform 1110011
geminin480048
muscarinic acetylcholine receptor M1290029
5-hydroxytryptamine receptor 1A016522
Adenosine receptor A3010415
Adenosine receptor A1010420
Adenosine receptor A10404
Adenosine receptor A30505
Adenosine receptor A2a010822
Adenosine receptor A2b05311
Adenosine receptor A2b05312
Adenosine receptor A1011723
Adenosine receptor A2a06318
Vasopressin V2 receptor0002
Mu-type opioid receptor015622
Adenosine receptor A10224
Adenylate cyclase type 50506
Adenylate cyclase type 10103
Sigma non-opioid intracellular receptor 108210
Chain A, Retinaldehyde-binding protein 10011
Chain A, Retinaldehyde-binding protein 10011
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, TYROSYL-DNA PHOSPHODIESTERASE180018
Chain A, HADH2 protein140014
Chain B, HADH2 protein140014
Chain A, JmjC domain-containing histone demethylation protein 3A9009
Chain A, 2-oxoglutarate Oxygenase170017
Chain A, Protocatechuate 3,4-dioxygenase0011
Chain M, Protocatechuate 3,4-dioxygenase0011
Olfactory receptor class A-like protein 10011
Luciferase100010
RGS121001
phosphopantetheinyl transferase180018
NFKB1 protein, partial150015
GLS protein340034
Microtubule-associated protein tau200020
Thrombopoietin120012
alkaline phosphatase, intestinal0011
thioredoxin glutathione reductase3003
apical membrane antigen 1, AMA17007
hypothetical protein, conserved3003
regulator of G-protein signaling 4350035
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein0101
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 18008
intestinal alkaline phosphatase precursor0101
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 11001
DNA polymerase beta4004
flap endonuclease 1130013
M-phase phosphoprotein 8170017
alkaline phosphatase, germ cell type preproprotein0011
POsterior Segregation0033
Prolyl 4-hydroxylase subunit alpha-10101
Sodium-dependent noradrenaline transporter 043952
Zinc finger protein mex-50022
ATP-dependent phosphofructokinase390039
cytochrome P450 2D6 isoform 1280028
cytochrome P450 2C9 precursor130013
D(1A) dopamine receptor390039
serine/threonine-protein kinase mTOR isoform 1190019
histone acetyltransferase KAT2A isoform 1150015
lethal factor (plasmid)170017
Histamine H2 receptor234135
Gamma-aminobutyric acid receptor subunit pi2111234
Calcium/calmodulin-dependent protein kinase type II subunit alpha0101
Gamma-aminobutyric acid receptor subunit beta-12111234
Gamma-aminobutyric acid receptor subunit delta2111234
Gamma-aminobutyric acid receptor subunit gamma-22111436
Gamma-aminobutyric acid receptor subunit alpha-52111234
Gamma-aminobutyric acid receptor subunit alpha-32111234
Gamma-aminobutyric acid receptor subunit gamma-12111234
Gamma-aminobutyric acid receptor subunit alpha-22111234
Gamma-aminobutyric acid receptor subunit alpha-42111234
Gamma-aminobutyric acid receptor subunit gamma-32111234
Gamma-aminobutyric acid receptor subunit alpha-62111234
Gamma-aminobutyric acid receptor subunit alpha-12111436
Gamma-aminobutyric acid receptor subunit beta-32111234
Gamma-aminobutyric acid receptor subunit beta-22111436
Tetraspanin0101
Proton-coupled amino acid transporter 10404
GABA theta subunit2111234
Gamma-aminobutyric acid receptor subunit epsilon2111234
Calcium/calmodulin-dependent protein kinase type II subunit alpha0101
Chain A, Beta-lactamase8008
vitamin D3 receptor isoform VDRA130013
Multidrug resistance-associated protein 4035036
Equilibrative nucleoside transporter 10404
Solute carrier family 28 member 30303
Adenosine kinase0103
dopamine D1 receptor140014
arylsulfatase A380038
D(2) dopamine receptor041959
D(3) dopamine receptor024228
5-hydroxytryptamine receptor 1A035340
Sodium-dependent dopamine transporter027229
D(3) dopamine receptor033647
D(2) dopamine receptor043754
Histamine H3 receptor0617
Sigma non-opioid intracellular receptor 1013114
Chain A, Membrane lipoprotein tmpC0011
Chain A, Membrane lipoprotein tmpC0011
Chain A, Membrane lipoprotein tmpC0011
Chain A, Structure of PAE2307 in complex with adenosine0011
Chain B, Structure of PAE2307 in complex with adenosine0011
Chain A, ADENOSINE RECEPTOR A2A0202
Chain A, ADENOSINE RECEPTOR A2A0202
Chain A, tRNA (guanine-N(1)-)-methyltransferase0011
Chain A, Uncharacterized protein MJ08830011
AR protein460046
signal transducer and activator of transcription 6, interleukin-4 induced1001
glucocorticoid receptor [Homo sapiens]300030
retinoid X nuclear receptor alpha250025
estrogen nuclear receptor alpha500050
NPYLR7B0011
IDH1170017
Histone H2A.x150015
glycogen synthase kinase-3 beta isoform 10011
mitogen-activated protein kinase 1170017
peripheral myelin protein 22330033
survival motor neuron protein isoform d130013
high affinity choline transporter 1 isoform a0101
Sodium/nucleoside cotransporter 10202
Calcium dependent protein kinase0101
Mitogen-activated protein kinase kinase kinase 70011
Sodium/nucleoside cotransporter 20202
Voltage-dependent calcium channel gamma-2 subunit150015
Rap guanine nucleotide exchange factor 34004
Purine nucleoside phosphorylase0101
Epidermal growth factor receptor0707
Phosphoglycerate kinase 1 0101
Adenosine deaminase0001
Avidin0011
Adenosine deaminase0001
Glyceraldehyde-3-phosphate dehydrogenase0202
Receptor tyrosine-protein kinase erbB-20303
Insulin receptor0001
Phosphoglycerate kinase 20101
Heat shock protein HSP 90-alpha0224
Platelet-derived growth factor receptor beta0001
Heat shock 70 kDa protein 1A 0101
Heat shock cognate 71 kDa protein0011
Fibroblast growth factor receptor 10001
Inosine-5'-monophosphate dehydrogenase 20101
Endoplasmin0224
Glutamate receptor 2162119
Inosine-5'-monophosphate dehydrogenase 1 0101
Fibroblast growth factor receptor 20001
Fibroblast growth factor receptor 40001
Fibroblast growth factor receptor 30001
Streptavidin0011
Adenosylhomocysteinase0001
Adenylate kinase 2, mitochondrial0101
Adenylate kinase isoenzyme 1 0101
Phosphatidylinositol 4-kinase alpha0203
Adenosine kinase0001
Adenosine deaminase 0001
Equilibrative nucleoside transporter 20202
Phosphatidylinositol 4-kinase type 2-beta0203
Histone-lysine N-methyltransferase, H3 lysine-79 specific0101
Phosphatidylinositol 4-kinase type 2-alpha0203
Phosphatidylinositol 4-kinase beta0203
5-methylthioadenosine/S-adenosylhomocysteine deaminase0001
Adenosine transporter 10001
Chain A, Endoplasmin0011
glp-1 receptor, partial150015
vasopressin V1b receptor1001
thyrotropin-releasing hormone receptor1001
relaxin receptor 1 isoform 11001
relaxin receptor 2 isoform 11001
Cytochrome P450 3A4022228
Transmembrane domain-containing protein TMIGD30101
Cytochrome P450 2C80808
Thyroid hormone receptor beta0303
Alpha-2B adrenergic receptor021426
Alpha-2C adrenergic receptor021426
Alpha-2A adrenergic receptor021426
5-hydroxytryptamine receptor 2A036240
Alpha-1A adrenergic receptor015629
Alpha-synuclein5207
Aflatoxin B1 aldehyde reductase member 30101
Endoplasmin0011
Adenosine receptor A10202
Endoplasmin0011
Adenosine receptor A10101
Adenosine receptor A30112
2-oxoglutarate receptor 10101
cytochrome P450 family 3 subfamily A polypeptide 4350035
G150015
cytochrome P450 2D6370037
Orexin receptor type 10719
Orexin receptor type 20618
Interferon beta210021
HLA class I histocompatibility antigen, B alpha chain 150015
Inositol hexakisphosphate kinase 1150015
cytochrome P450 2C9, partial150015
Solute carrier family 22 member 30303
5-hydroxytryptamine receptor 2C026329
Phenylethanolamine N-methyltransferase0303
Cytochrome P450 2A60415
Substance-P receptor0101
5-hydroxytryptamine receptor 2A025430
Cytochrome P450 2A50202
5-hydroxytryptamine receptor 1B027230
5-hydroxytryptamine receptor 1D012215
5-hydroxytryptamine receptor 1F012215
5-hydroxytryptamine receptor 2B023427
5-hydroxytryptamine receptor 60628
5-hydroxytryptamine receptor 7 015217
5-hydroxytryptamine receptor 5A0628
5-hydroxytryptamine receptor 5B0628
5-hydroxytryptamine receptor 3A0729
5-hydroxytryptamine receptor 4 0628
Beta-2 adrenergic receptor0416
5-hydroxytryptamine receptor 3B0729
Chain A, retinol dehydratase0101
acetylcholinesterase160016
RAR-related orphan receptor gamma320032
GLI family zinc finger 3410041
estrogen receptor 2 (ER beta)190019
progesterone receptor250025
retinoic acid nuclear receptor alpha variant 1300030
pregnane X nuclear receptor340034
v-jun sarcoma virus 17 oncogene homolog (avian)220022
Sex hormone-binding globulin0044
Corticosteroid-binding globulin0505
Glucose-6-phosphate 1-dehydrogenase0303
Androgen receptor0303
Solute carrier organic anion transporter family member 1A10202
TAR DNA-binding protein 438008
G-protein coupled bile acid receptor 10033
neuropeptide S receptor isoform A7007
Chain A, Putative fructose-1,6-bisphosphate aldolase4004
hypoxia-inducible factor 1 alpha subunit100010
nuclear receptor subfamily 1, group I, member 3290029
farnesoid X nuclear receptor180018
peroxisome proliferator-activated receptor delta180018
peroxisome proliferator activated receptor gamma190019
aryl hydrocarbon receptor200020
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a190019
thyroid stimulating hormone receptor210021
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a140014
cellular tumor antigen p53 isoform a110011
cytochrome P450 2C19 precursor180018
potassium voltage-gated channel subfamily H member 2 isoform d250025
thyroid hormone receptor beta isoform 2330033
nuclear factor erythroid 2-related factor 2 isoform 1310031
cytochrome P450 3A4 isoform 1210021
Solute carrier family 22 member 1 019024
Polyunsaturated fatty acid lipoxygenase ALOX15B150015
ATP-binding cassette sub-family C member 3034034
Bile salt export pump059059
Cellular tumor antigen p53250025
Integrin beta-38019
Integrin alpha-IIb8019
Tryptophan 5-hydroxylase 10707
D026029
D(2) dopamine receptor0808
D(1A) dopamine receptor026536
D(4) dopamine receptor021331
D(1B) dopamine receptor012016
D(1B) dopamine receptor016016
D(4) dopamine receptor017118
5-hydroxytryptamine receptor 7013013
E3 ubiquitin-protein ligase Mdm20101
D0303
Canalicular multispecific organic anion transporter 1034034
D0808
ATPase family AAA domain-containing protein 5110011
Ataxin-2300030
Sigma non-opioid intracellular receptor 1028028
5-hydroxytryptamine receptor 3E0303
SMAD family member 27007
Fumarate hydratase160016
USP1 protein, partial210021
PPM1D protein2002
SMAD family member 37007
EWS/FLI fusion protein220022
polyprotein160016
vitamin D (1,25- dihydroxyvitamin D3) receptor180018
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)6006
mu-type opioid receptor isoform MOR-10022
transcriptional regulator ERG isoform 36006
heat shock protein beta-17007
5-hydroxytryptamine receptor 2A0022
Solute carrier family 22 member 207010
5-hydroxytryptamine receptor 3A0213
5-hydroxytryptamine receptor 3B0303
ATP-dependent translocase ABCB1017022
Neuronal acetylcholine receptor subunit alpha-416311
Neuronal acetylcholine receptor subunit beta-216311
Alpha-2C adrenergic receptor032640
Alpha-1D adrenergic receptor028437
5-hydroxytryptamine receptor 2C033235
Histamine H1 receptor0639
Sodium-dependent serotonin transporter045752
5-hydroxytryptamine receptor 7010111
Histamine H1 receptor028434
Alpha-1B adrenergic receptor010520
5-hydroxytryptamine receptor 2B031233
5-hydroxytryptamine receptor 3A0303
5-hydroxytryptamine receptor 6030132
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0303
Inositol monophosphatase 1140014
Potassium voltage-gated channel subfamily H member 2039039
5-hydroxytryptamine receptor 3D0303
Multidrug and toxin extrusion protein 20505
5-hydroxytryptamine receptor 3C0303
Multidrug and toxin extrusion protein 10606
Histamine H3 receptor018628
Chain A, Ferritin light chain6006
Metabotropic glutamate receptor 60124
Excitatory amino acid transporter 40202
Glutamate transporter homolog0011
Carbonic anhydrase 107017
Carbonic anhydrase 207119
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase0101
5-hydroxytryptamine receptor 1D0204
Glutamate receptor ionotropic, NMDA 1 010217
Excitatory amino acid transporter 10304
Excitatory amino acid transporter 20304
Excitatory amino acid transporter 30304
Glutamate receptor ionotropic, NMDA 2A 010217
Glutamate receptor ionotropic, NMDA 2B011218
Glutamate receptor ionotropic, NMDA 2C010217
Metabotropic glutamate receptor 10124
Metabotropic glutamate receptor 20124
Carbonic anhydrase-like protein, putative0008
Glutamate receptor ionotropic, NMDA 2D010217
Glutamate receptor ionotropic, NMDA 3B010217
Carbonic anhydrase 40305
Glutamate receptor ionotropic, NMDA 3A010217
cystic fibrosis transmembrane conductance regulator0101
short transient receptor potential channel 6 isoform 10022
5-hydroxytryptamine receptor 4028028
Muscarinic acetylcholine receptor M1018224
Muscarinic acetylcholine receptor M3017222
Muscarinic acetylcholine receptor M4018122
Muscarinic acetylcholine receptor M5018122
Muscarinic acetylcholine receptor M2019225
Muscarinic acetylcholine receptor M10225
Muscarinic acetylcholine receptor M40303
Reverse transcriptase/RNaseH 0127
activating transcription factor 68008
Gamma-aminobutyric acid type B receptor subunit 20224
Gamma-aminobutyric acid type B receptor subunit 20303
Gamma-aminobutyric acid type B receptor subunit 10224
Gamma-aminobutyric acid type B receptor subunit 10202
Zinc finger protein mex-50011
Genome polyprotein0101
Replicase polyprotein 1ab0527
D(1A) dopamine receptor133016
Hexokinase-20101
GALC protein9009
thyrotropin-releasing hormone receptor1001
Neuronal acetylcholine receptor subunit alpha-30438
Neuronal acetylcholine receptor subunit alpha-20438
Neuronal acetylcholine receptor subunit beta-30438
Neuronal acetylcholine receptor subunit beta-40438
Neuronal acetylcholine receptor subunit alpha-50438
Delta-type opioid receptor08112
Neuronal acetylcholine receptor subunit alpha-60438
Neuronal acetylcholine receptor subunit alpha-90438
Neuronal acetylcholine receptor subunit alpha-706310
Muscarinic acetylcholine receptor M30114
Muscarinic acetylcholine receptor M20104
Neuronal acetylcholine receptor subunit alpha-100438
thyroid hormone receptor beta isoform a100010
Vpr1001
Bile salt export pump0808
Albumin0088
Major prion protein0044
Sodium channel protein type 1 subunit alpha0303
Sodium channel protein type 2 subunit alpha0404
Sodium channel protein type 3 subunit alpha0202
Cytochrome P450 2C9 015016
UDP-glucuronosyltransferase 2B70105
Cytochrome P450 2B60112
Sodium channel protein type 4 subunit alpha0709
Cytochrome P450 2J2011012
Sodium channel protein type 9 subunit alpha0808
Frizzled-80011
P2X purinoceptor 40202
Proteasome subunit beta type-110001
Smad3100010
caspase 7, apoptosis-related cysteine protease130013
NADPH oxidase 10202
Snq2p0004
caspase-3130013
Adenylate cyclase type 1 0404
Caspase-75005
Spike glycoprotein0123
Replicase polyprotein 1ab0123
caspase-35005
histone deacetylase 9 isoform 32002
atrial natriuretic peptide receptor 2 precursor120012
ras-related protein Rab-9A140014
DNA polymerase kappa isoform 19009
Proteasome subunit alpha type-70001
Transmembrane protease serine 20123
Glutamate receptor ionotropic, NMDA 2D0303
Transient receptor potential cation channel subfamily V member 10202
Glutamate receptor ionotropic, NMDA 3B0303
Voltage-dependent L-type calcium channel subunit alpha-1F0909
Potassium channel subfamily K member 20538
Albumin0145
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10202
Major prion protein0011
Cytochrome P450 1A20629
Tyrosine-protein kinase Fyn0404
Procathepsin L0123
Aldo-keto reductase family 1 member B1024024
Alpha-2A adrenergic receptor039748
Replicase polyprotein 1a0123
Replicase polyprotein 1ab0123
Replicase polyprotein 1ab0224
Cys-loop ligand-gated ion channel0101
Calmodulin-10325
Cytochrome P450 2D6018120
Polyunsaturated fatty acid lipoxygenase ALOX150404
Angiotensin-converting enzyme021021
Sphingomyelin phosphodiesterase0202
Alpha-2B adrenergic receptor035340
Proteasome subunit beta type-10001
Substance-K receptor0606
Adenylate cyclase type 30404
UDP-glucuronosyltransferase 1A40005
Histamine H2 receptor021223
Proteasome subunit alpha type-10001
Proteasome subunit alpha type-20001
Proteasome subunit alpha type-30001
Proteasome subunit alpha type-40001
Adenylate cyclase type 20404
Adenylate cyclase type 40404
Proteasome subunit beta type-80001
Proteasome subunit beta type-90001
Proteasome subunit alpha type-50001
Proteasome subunit beta type-40001
Proteasome subunit beta type-60001
Proteasome subunit beta type-50001
Trypanothione reductase0606
Melanocortin receptor 40202
Melanocortin receptor 50202
Pleiotropic ABC efflux transporter of multiple drugs0408
Sodium channel protein type 1 subunit alpha0404
Adenylate cyclase type 80404
Proteasome subunit beta type-100001
Delta-type opioid receptor010415
Kappa-type opioid receptor010415
Melanocortin receptor 30202
Proteasome subunit beta type-30001
Proteasome subunit beta type-20001
Gastrin/cholecystokinin type B receptor0303
Proteasome subunit alpha type-60034
Calmodulin 0134
Aldehyde oxidase 10101
Sodium channel protein type 7 subunit alpha0404
Voltage-dependent L-type calcium channel subunit alpha-1D 0909
Sodium-dependent dopamine transporter 039444
Adenylate cyclase type 60404
Glutamate receptor ionotropic, NMDA 10404
Aldehyde oxidase0204
Glutamate receptor ionotropic, NMDA 2A0404
Glutamate receptor ionotropic, NMDA 2B0404
Voltage-dependent L-type calcium channel subunit alpha-1S0909
Voltage-dependent L-type calcium channel subunit alpha-1C011011
Sodium channel protein type 5 subunit alpha010010
Glutamate receptor ionotropic, NMDA 2C0303
Nuclear receptor subfamily 3 group C member 3 020020
Adenylyl cyclase 7 0404
Proteasome subunit alpha-type 80001
Glutamate receptor ionotropic, NMDA 3A0303
Sodium channel protein type 2 subunit alpha0505
Proteasome subunit beta type-70001
Angiotensin-converting enzyme 2 0123
Sodium channel protein type 3 subunit alpha0505
Sodium channel protein type 11 subunit alpha0404
Sodium channel protein type 8 subunit alpha0404
Sodium channel protein type 10 subunit alpha0505
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein0011
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Choline-binding protein0011
Solute carrier family 22 member 10203
Solute carrier family 22 member 20101
Acetylcholinesterase013216
Sodium- and chloride-dependent creatine transporter 10101
Choline O-acetyltransferase 0102
Solute carrier family 22 member 108010
High affinity choline transporter 10101
Solute carrier family 22 member 20507
Parkin2002
NPC intracellular cholesterol transporter 1 precursor100010
Cholinesterase010010
Amine oxidase [flavin-containing] A012013
Amine oxidase [flavin-containing] B012114
Histamine H4 receptor09516
Sodium-dependent noradrenaline transporter0505
Aldo-keto reductase family 1 member B10202
Aromatase0101
Sodium-dependent serotonin transporter021223
Sigma intracellular receptor 20707
Sodium-dependent serotonin transporter0505
Sodium-dependent dopamine transporter0707
Transporter018120
atrial natriuretic peptide receptor 1 precursor6006
Histamine H1 receptor012113
Trypanothione reductase0101
Voltage-dependent N-type calcium channel subunit alpha-1B0606
Envelope glycoprotein0033
2,3-bisphosphoglycerate-independent phosphoglycerate mutase1001
Gamma-aminobutyric acid receptor subunit pi0707
Gamma-aminobutyric acid receptor subunit delta0707
Gamma-aminobutyric acid receptor subunit alpha-10102
Gamma-aminobutyric acid receptor subunit beta-10102
Gamma-aminobutyric acid receptor subunit alpha-20102
Gamma-aminobutyric acid receptor subunit alpha-30102
Gamma-aminobutyric acid receptor subunit alpha-10729
Gamma-aminobutyric acid receptor subunit beta-10729
Gamma-aminobutyric acid receptor subunit gamma-20729
Gamma-aminobutyric acid receptor subunit alpha-40102
Gamma-aminobutyric acid receptor subunit gamma-20102
Gamma-aminobutyric acid receptor subunit beta-30729
Translocator protein0101
Translocator protein0202
Cholecystokinin receptor type A0101
Gastrin/cholecystokinin type B receptor0101
Gamma-aminobutyric acid receptor subunit alpha-50729
Gamma-aminobutyric acid receptor subunit alpha-30729
Gamma-aminobutyric acid receptor subunit alpha-20729
Gamma-aminobutyric acid receptor subunit beta-20729
Gamma-aminobutyric acid receptor subunit alpha-40729
Gamma-aminobutyric acid receptor subunit epsilon0707
Gamma-aminobutyric acid receptor subunit alpha-60729
Gamma-aminobutyric acid receptor subunit gamma-10707
Gamma-aminobutyric acid receptor subunit gamma-30707
Gamma-aminobutyric acid receptor subunit theta0707
Chain A, Cruzipain2002
Beta-1 adrenergic receptor 0225
Alpha-1B adrenergic receptor 0022
Membrane primary amine oxidase 0101
Solute carrier family 22 member 30708
Alpha-1A adrenergic receptor0426
Alpha-2B adrenergic receptor0204
Mu-type opioid receptor0819
Alpha-2C adrenergic receptor0204
Alpha-2A adrenergic receptor0204
Alpha-2A adrenergic receptor0202
Nischarin0202
Nischarin0101
bromodomain adjacent to zinc finger domain 2B8008
transient receptor potential cation channel subfamily V member 12002
Beta-2 adrenergic receptor0607
Beta-1 adrenergic receptor0618
Endothelin receptor type B0101
5-hydroxytryptamine receptor 3A0202
Endothelin receptor type B0101
Beta-3 adrenergic receptor0404
Cytochrome P450 2C1908010
5-hydroxytryptamine receptor 2C 0404
5-hydroxytryptamine receptor 2A0303
5-hydroxytryptamine receptor 5A0202
D(2) dopamine receptor0202
D(3) dopamine receptor0202
D(2) dopamine receptor0505
5-hydroxytryptamine receptor 2B0303
5-hydroxytryptamine receptor 40202
Transporter0606
Cholecystokinin receptor type A0202
5-hydroxytryptamine receptor 1A0202
Sodium- and chloride-dependent creatine transporter 10101
Beta-glucuronidase0101
Beta-glucuronidase0101
Glucose-6-phosphate 1-dehydrogenase 0101
NPC1-like intracellular cholesterol transporter 10011
huntingtin isoform 25005
Prostaglandin G/H synthase 10303
Solute carrier family 22 member 40101
Amine oxidase [flavin-containing] B09010
Amine oxidase [flavin-containing] B0505
Trace amine-associated receptor 10022
Trace amine-associated receptor 10022
Trace amine-associated receptor 10022
Trace amine-associated receptor 10033
Chain A, ATP-DEPENDENT DNA HELICASE Q13003
15-lipoxygenase, partial9009
polyunsaturated fatty acid lipoxygenase ALOX121001
runt-related transcription factor 1 isoform AML1b1001
core-binding factor subunit beta isoform 21001
Glutamate receptor 11214
Glutamate receptor 31214
Glutamate receptor 41214
Caspase-72002
prostaglandin E2 receptor EP2 subtype1001
Solute carrier organic anion transporter family member 1A50003
Prostaglandin E2 receptor EP3 subtype0101
Prostaglandin E2 receptor EP4 subtype0101
Prostaglandin E2 receptor EP1 subtype0213
Prostaglandin E2 receptor EP1 subtype0101
Prostaglandin E2 receptor EP4 subtype0213
Prostaglandin F2-alpha receptor0011
Prostaglandin E2 receptor EP4 subtype0112
Prostaglandin E2 receptor EP3 subtype0213
Prostaglandin E2 receptor EP2 subtype0213
Prostacyclin receptor0213
Solute carrier organic anion transporter family member 2A10001
Solute carrier family 22 member 60002
Solute carrier family 22 member 70002
Prostaglandin E2 receptor EP2 subtype0101
Prostaglandin E2 receptor EP2 subtype0112
Solute carrier family 22 member 200202
Solute carrier family 22 member 80002
Solute carrier family 22 member 60202
Solute carrier family 22 member 70001
Solute carrier organic anion transporter family member 2A10001
Solute carrier family 22 member 110002
Solute carrier organic anion transporter family member 1B20001
Solute carrier family 22 member 70002
Acetylcholinesterase010011
cGMP-specific 3',5'-cyclic phosphodiesterase0101
Acetylcholinesterase0303
Amyloid-beta precursor protein0202
Amine oxidase [flavin-containing] A 0607
Amine oxidase [flavin-containing] A 0303
Acetylcholinesterase0303
Liver carboxylesterase 10102
Acetylcholinesterase 0404
Acetylcholinesterase0202
Glycogen synthase kinase-3 beta0101
Beta-secretase 10101
Cholinesterase0708
Cholinesterase0202
Acetylcholine receptor subunit epsilon0123
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0505
Cytochrome P450 1B10404
Acyl-CoA:cholesterol acyltransferase 0202
Carboxylic ester hydrolase 0203
Carboxylic ester hydrolase 0404
importin subunit beta-1 isoform 14004
snurportin-14004
GTP-binding nuclear protein Ran isoform 12002
urokinase-type plasminogen activator precursor4004
plasminogen precursor4004
urokinase plasminogen activator surface receptor precursor4004
chaperonin-containing TCP-1 beta subunit homolog1001
ubiquitin-conjugating enzyme E2 N0101
protein AF-9 isoform a0001
histone-lysine N-methyltransferase 2A isoform 2 precursor7007
Estrogen receptor0606
Beta-3 adrenergic receptor0426
Prostaglandin G/H synthase 10303
C-8 sterol isomerase0303
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0303
Opioid receptor, delta 1b 0202
Opioid receptor homologue0202
Proenkephalin-B0011
Delta-type opioid receptor09111
Kappa-type opioid receptor0326
Mu-type opioid receptor09113
Kappa-type opioid receptor0517
Kappa-type opioid receptor0505
Mu-type opioid receptor0327
Mu-type opioid receptor0202
Glucocorticoid receptor04110
Glycine receptor subunit alpha-10404
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
Lanosterol 14-alpha demethylase0011
Olfactory receptor 51E20033
UDP-glucuronosyltransferase 1A100001
Chain H, IGG1-KAPPA DB3 FAB (HEAVY CHAIN)0101
Chain L, IGG1-KAPPA DB3 FAB (LIGHT CHAIN)0101
Chain H, IGG1-KAPPA DB3 FAB (HEAVY CHAIN)0101
Chain L, IGG1-KAPPA DB3 FAB (LIGHT CHAIN)0101
Chain H, IGG1-KAPPA DB3 FAB (HEAVY CHAIN)0101
Chain L, IGG1-KAPPA DB3 FAB (LIGHT CHAIN)0101
ClpP4004
Testosterone 17-beta-dehydrogenase 30101
Guanine nucleotide-binding protein G3003
Dipeptidyl peptidase 40101
Potassium voltage-gated channel subfamily C member 10101
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0404
Gastrin/cholecystokinin type B receptor 0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0404
Cytochrome P450 1A2 0202
Gamma-aminobutyric acid 0011
Gamma-aminobutyric acid receptor subunit rho-30011
Hsf1 protein0011
Histone deacetylase 30101
Gamma-aminobutyric acid receptor subunit alpha-60011
Gamma-aminobutyric acid receptor subunit gamma-20011
Gamma-aminobutyric acid receptor subunit delta0011
Sodium- and chloride-dependent GABA transporter 10303
Gamma-aminobutyric acid receptor subunit rho-10044
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit gamma-30011
Gamma-aminobutyric acid receptor subunit rho-20022
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0101
Sodium- and chloride-dependent GABA transporter 20303
Sodium- and chloride-dependent GABA transporter 30303
Sodium- and chloride-dependent GABA transporter 10202
Sodium- and chloride-dependent GABA transporter 20303
Sodium- and chloride-dependent GABA transporter 30303
Sodium- and chloride-dependent betaine transporter0303
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit beta-10011
Histone deacetylase 40101
Gamma-aminobutyric acid receptor subunit alpha-10011
Gamma-aminobutyric acid receptor subunit beta-30011
4-aminobutyrate aminotransferase, mitochondrial0001
4-aminobutyrate aminotransferase, mitochondrial0001
Histone deacetylase 10101
Sterol O-acyltransferase 10011
Gamma-aminobutyric acid receptor subunit alpha-50011
Gamma-aminobutyric acid receptor subunit pi0011
Histone deacetylase 70101
Histone deacetylase 20101
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
Histone deacetylase 80101
Gamma-aminobutyric acid receptor subunit alpha-40011
Platelet glycoprotein VI0011
Gamma-aminobutyric acid receptor subunit theta0011
Sodium- and chloride-dependent GABA transporter 20101
Gamma-aminobutyric acid receptor subunit gamma-10011
Histone deacetylase 60101
Histone deacetylase 90101
Histone deacetylase 50101
Chain A, GLUTAMATE RECEPTOR SUBUNIT 20101
Chain A, Glutamate Receptor Subunit 20101
Chain B, Glutamate Receptor Subunit 20101
Chain A, Slr1257 protein0011
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]0101
beta-2 adrenergic receptor2002
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1100010
Metabotropic glutamate receptor 80202
Glutathione reductase, mitochondrial0202
Bifunctional aspartokinase/homoserine dehydrogenase 10101
Prothrombin0022
ATP-citrate synthase 0101
Glutamate receptor ionotropic, kainate 10213
Metabotropic glutamate receptor 10213
Metabotropic glutamate receptor 20011
Metabotropic glutamate receptor 30011
Metabotropic glutamate receptor 40112
Metabotropic glutamate receptor 50123
Metabotropic glutamate receptor 60011
Metabotropic glutamate receptor 70011
Glutamate receptor ionotropic, kainate 10112
Metabotropic glutamate receptor 50124
Glutamate receptor ionotropic, kainate 20213
Glutamate receptor 10213
Glutamate receptor 20213
Glutamate receptor 30112
Glutamate receptor ionotropic, kainate 30202
Metabotropic glutamate receptor 80011
Glutamate receptor 40213
Excitatory amino acid transporter 3 0001
Glutamate racemase0001
Metabotropic glutamate receptor 80112
Fatty-acid amide hydrolase 10202
Glutamate receptor ionotropic, kainate 40202
Glutamate carboxypeptidase 20101
Glutamate receptor ionotropic, kainate 20112
Glutamate receptor ionotropic, kainate 30101
Metabotropic glutamate receptor 70113
Metabotropic glutamate receptor 30113
Metabotropic glutamate receptor 40113
Glutamate receptor ionotropic, kainate 50101
Glutamate receptor ionotropic, kainate 50202
Glutamate racemase0001
Prolyl 4-hydroxylase0101
Alpha-ketoglutarate-dependent dioxygenase FTO0101
Chain A, Glutamine Binding Protein0011
Neutral amino acid transporter A0101
Asc-type amino acid transporter 10101
Neutral amino acid transporter B(0)0101
Amino acid transporter0101
Glycine receptor subunit alpha-10033
Sodium- and chloride-dependent glycine transporter 10101
Large neutral amino acids transporter small subunit 10607
Serine racemase0101
Sodium- and chloride-dependent glycine transporter 20101
Chain A, ras-related C3 botulinum toxin substrate 1 isoform Rac1b0011
Chain A, ras-related C3 botulinum toxin substrate 1 isoform Rac1b0011
Protein-glutamine gamma-glutamyltransferase 20101
nonstructural protein 13003
Cocaine esterase0101
Voltage-dependent L-type calcium channel subunit alpha-1C0404
UDP-glucuronosyltransferase 1A90102
Vitamin D-binding protein0101
HLA class I histocompatibility antigen, A alpha chain 0011
Integrin beta-10101
Integrin alpha-40101
Carbonyl reductase [NADPH] 10001
5-hydroxytryptamine receptor 2A0213
AP-2 complex subunit sigma0101
N-acetyltransferase Eis0202
Calcitonin gene-related peptide type 1 receptor0101
Genome polyprotein 0202
Sigma intracellular receptor 20101
Zinc finger protein 6640101
Vesicular acetylcholine transporter0101
Protease 0314
Transient receptor potential cation channel subfamily V member 40101
Transient receptor potential cation channel subfamily V member 20101
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Protein (female-specific Histamine Binding Protein 2)0011
aryl hydrocarbon receptor nuclear translocator0001
transforming acidic coiled-coil-containing protein 30001
Carbonic anhydrase 120208
Plasma kallikrein0005
Carbonic anhydrase 30207
Macrophage migration inhibitory factor0202
Carbonic anhydrase 40309
Carbonic anhydrase 60309
Carbonic anhydrase 5A, mitochondrial03110
Carbonic anhydrase0207
Carbonic anhydrase 70208
Carbonic anhydrase0208
Histamine H3 receptor0314
Histamine N-methyltransferase 0101
Glutaminyl-peptide cyclotransferase0101
Carbonic anhydrase 903010
Carbonic anhydrase 0208
Carbonic anhydrase0107
Carbonic anhydrase0208
Carbonic anhydrase 0208
Equilibrative nucleoside transporter 40001
Carbonic anhydrase 130103
Histamine H4 receptor0224
Histamine H4 receptor0235
Histamine H4 receptor 0101
Carbonic anhydrase 150308
Carbonic anhydrase 130106
Histamine H3 receptor0314
Carbonic anhydrase 140107
Carbonic anhydrase 5B, mitochondrial0309
Solute carrier family 22 member 80001
Uracil nucleotide/cysteinyl leukotriene receptor0202
UDP-glucuronosyltransferase 1A30002
Chain B, Pulmonary surfactant-associated protein D0101
Chain A, Pulmonary surfactant-associated protein D0101
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
Sodium/myo-inositol cotransporter 20101
Chymotrypsinogen A0202
Estrogen receptor beta0202
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial0101
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial0202
Cytochrome P450 26A10101
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
3',5'-cyclic-AMP phosphodiesterase 0101
Camphor 5-monooxygenase0001
Phospholipase A2, major isoenzyme0101
Beta-lactamase0101
Steroid 17-alpha-hydroxylase/17,20 lyase0202
ATP-dependent translocase ABCB10505
Epoxide hydrolase 10001
Cytochrome P450 2C11 0202
Steroid 21-hydroxylase0101
Aromatase0303
Steroid 17-alpha-hydroxylase/17,20 lyase 0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Cholesterol side-chain cleavage enzyme, mitochondrial 0101
Indoleamine 2,3-dioxygenase 10304
Cytochrome P450 2A20101
Cytochrome P450 11B1, mitochondrial 0101
Cytochrome P450 11B1, mitochondrial0101
Translocator protein0213
Cytochrome P450 7A1 0101
Cytochrome P450 11B2, mitochondrial0101
Estrogen receptor0202
ATP-dependent translocase ABCB10505
UDP-glucuronosyltransferase 1A1 0202
Thromboxane-A synthase 0101
Gonadotropin-releasing hormone receptor0112
Type-1 angiotensin II receptor0202
Malate dehydrogenase, cytoplasmic0101
Cytochrome P450 4F20202
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial0202
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial0101
Sodium/bile acid cotransporter0202
Lanosterol 14-alpha demethylase0213
Cytochrome P450 7A10101
Lanosterol 14-alpha demethylase 0202
Dihydrofolate reductase0416
Potassium voltage-gated channel subfamily E member 10101
Potassium voltage-gated channel subfamily KQT member 10101
WRN1001
integrase, partial0101
lens epithelium-derived growth factor p750101
pyruvate kinase1001
hexokinase-4 isoform 13003
glucokinase regulatory protein3003
ubiquitin carboxyl-terminal hydrolase 2 isoform a3003
DNA polymerase eta isoform 13003
Polyphenol oxidase 20002
Tyrosine-protein kinase Lck0101
Tyrosinase0101
Solute carrier family 15 member 10101
SLC16A10 protein0004
Monocarboxylate transporter 100004
phosphoglycerate kinase1001
Fatty acid-binding protein, liver0202
Beta-2 adrenergic receptor0426
Beta-1 adrenergic receptor0325
Catechol O-methyltransferase0101
5-hydroxytryptamine receptor 1E0101
Sodium-dependent dopamine transporter0101
histone-lysine N-methyltransferase NSD2 isoform 10001
MBT domain-containing protein 10101
Lethal(3)malignant brain tumor-like protein 40101
Lethal(3)malignant brain tumor-like protein 30101
Lethal(3)malignant brain tumor-like protein 10101
Acetylcholine receptor subunit alpha0224
Acetylcholine receptor subunit gamma0224
Acetylcholine receptor subunit beta0224
Neuronal acetylcholine receptor subunit beta-20315
Neuronal acetylcholine receptor subunit beta-40315
Neuronal acetylcholine receptor subunit alpha-30314
Neuronal acetylcholine receptor subunit alpha-70325
Neuronal acetylcholine receptor subunit alpha-40315
Acetylcholine receptor subunit delta0224
Neuronal acetylcholine receptor subunit alpha-20202
interleukin 83003
Cytochrome P450 1A10303
Myeloperoxidase0303
Ribosyldihydronicotinamide dehydrogenase [quinone]0303
Nociceptin receptor0101
Melatonin receptor type 1A0213
Melatonin receptor type 1C0011
Melatonin receptor type 1A0112
Melatonin receptor type 1B0213
Melatonin receptor type 1C0112
Melatonin receptor type 1B0112
Nuclear receptor ROR-gamma5005
Nuclear factor erythroid 2-related factor 20001
Palmitoleoyl-protein carboxylesterase NOTUM0112
Synaptic vesicular amine transporter0202
Chain A, Methionyl-tRNA synthetase0011
Chain A, Methionyl-tRNA synthetase0011
Chain A, Aminopeptidase0101
Chain A, Methionine aminopeptidase0101
S-ribosylhomocysteine lyase0101
Adenylate cyclase type 50102
S-adenosylmethionine synthase isoform type-10001
S-adenosylmethionine synthase isoform type-20001
Fatty acid synthase0101
DNA polymerase III, partial2002
Sucrase-isomaltase 0101
Ceramide glucosyltransferase0101
Beta-galactosidase0101
Lysosomal alpha-glucosidase0101
Non-lysosomal glucosylceramidase0101
Acyl-CoA desaturase 10101
Histidine decarboxylase0011
Proteinase-activated receptor 10112
Nociceptin receptor0101
Mu-type opioid receptor0101
Mas-related G-protein coupled receptor member X20011
D-amino-acid oxidase0101
5-hydroxytryptamine receptor 1B0101
Rap guanine nucleotide exchange factor 41001
Neuronal acetylcholine receptor subunit alpha-40213
Transient receptor potential cation channel subfamily A member 10011
Acetylcholine receptor subunit alpha0213
Acetylcholine receptor subunit beta0213
Acetylcholine receptor subunit gamma0213
Acetylcholine receptor subunit delta0213
Neuronal acetylcholine receptor subunit alpha-40101
Acetylcholine receptor subunit beta-like 20202
Neuronal acetylcholine receptor subunit alpha-50011
Neuronal acetylcholine receptor subunit alpha-70202
Acetylcholine-binding protein0112
Neuronal acetylcholine receptor subunit beta-30112
Neuronal acetylcholine receptor subunit alpha-60112
Cytochrome P450 2A130213
Neuronal acetylcholine receptor subunit alpha-50202
Liver carboxylesterase B-10101
Transient receptor potential cation channel subfamily A member 10011
Neuronal acetylcholine receptor subunit beta-30202
Neuronal acetylcholine receptor subunit beta-40202
Neuronal acetylcholine receptor subunit alpha-30202
Soluble acetylcholine receptor0101
Neuronal acetylcholine receptor subunit alpha-20202
Neuronal acetylcholine receptor subunit beta-20213
Neuronal acetylcholine receptor subunit alpha-60202
Integrin beta0011
Glycoprotein IIb0011
Cytochrome P450 2D10101
Cytochrome P450 2D260101
Cytochrome P450 2D30101
Sodium- and chloride-dependent betaine transporter0101
Cytochrome P450 2D40101
MCOLN3 protein0011
transient receptor potential cation channel, subfamily N, member 10011
Muscarinic acetylcholine receptor DM10202
Mineralocorticoid receptor0011
Quinolone resistance protein NorA0203
Beta-adrenergic receptor kinase 10101
Potassium voltage-gated channel subfamily A member 30101
Beta-adrenergic receptor kinase 10112
Substance-P receptor0101
Rhodopsin kinase GRK10101
G protein-coupled receptor kinase 50101
G protein-coupled receptor kinase 50101
P2X purinoceptor 40101
Rhodopsin kinase GRK10101
Beta-adrenergic receptor kinase 10001
Lysine-specific histone demethylase 1A0304
Membrane primary amine oxidase0101
Single-stranded DNA cytosine deaminase1001
Chain A, AMINOPEPTIDASE0101
Chain A, AMINOPEPTIDASE0101
Voltage-dependent calcium channel subunit alpha-2/delta-10101
Alkaline phosphatase, tissue-nonspecific isozyme0404
Alkaline phosphatase, tissue-nonspecific isozyme 0101
Intestinal-type alkaline phosphatase0303
Intestinal-type alkaline phosphatase0101
5'-nucleotidase0101
E3 ubiquitin-protein ligase XIAP0101
Large neutral amino acids transporter small subunit 1 0101
Phospholipase A-2-activating protein0303
POU domain, class 2, transcription factor 10001
Alpha-1B adrenergic receptor0202
Acetylcholinesterase0101
pregnane X receptor2002
XBP10101
nuclear factor NF-kappa-B p105 subunit isoform 12002
DNA damage-inducible transcript 3 protein0101
Voltage-dependent T-type calcium channel subunit alpha-1G0011
Ubiquitin carboxyl-terminal hydrolase 10202
Disintegrin and metalloproteinase domain-containing protein 172002
WD repeat-containing protein 480202
Muscarinic acetylcholine receptor M50101
interferon gamma precursor0002
Alpha-1A adrenergic receptor0213
Beta-casein0101
Interstitial collagenase0101
Matrix metalloproteinase-90101
Alpha-2A adrenergic receptor0202
Alpha-mannosidase 2C10011
Bromodomain-containing protein 20202
5-hydroxytryptamine receptor 1B0314
3-oxo-5-alpha-steroid 4-dehydrogenase 20101
Broad substrate specificity ATP-binding cassette transporter ABCG20203
luciferase0001
nuclear receptor subfamily 1, group I, member 22002
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Mineralocorticoid receptor 0213
Androgen receptor0303
Glutamine synthetase0011
Prostaglandin G/H synthase 20103
Nociceptin receptor0011
Estrogen receptor beta0202
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Endothelin-1 receptor0112
Neuromedin-K receptor0011
Type-1 angiotensin II receptor0112
Cholecystokinin receptor type A0112
Beta-1 adrenergic receptor0101
Vasopressin V1a receptor0112
Beta-2 adrenergic receptor0101
Nuclear receptor subfamily 2 group E member 10022
chaperonin GroEL1001
Sulfotransferase 1A10101
Sulfotransferase 2A10101
dual specificity protein phosphatase 30101
low molecular weight phosphotyrosine protein phosphatase isoform c0101
tyrosine-protein phosphatase non-receptor type 22 isoform 10101
streptokinase A precursor0011
cGMP-dependent 3',5'-cyclic phosphodiesterase0202
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Dihydrofolate reductase0404
Dihydrofolate reductase 0101
Estrogen receptor0011
Beta-hexosaminidase subunit alpha0102
Beta-hexosaminidase subunit beta0101
Bifunctional dihydrofolate reductase-thymidylate synthase0202
Dihydrofolate reductase0202
Substance-K receptor0101
Dihydrofolate reductase0101
Low molecular weight phosphotyrosine protein phosphatase0101
Dipeptidyl peptidase 40213
Pteridine reductase 10101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Trace amine-associated receptor 50011
Estrogen receptor beta0011
Bifunctional dihydrofolate reductase-thymidylate synthase0202
Multidrug and toxin extrusion protein 10101
Dihydrofolate reductase0101
Dipeptidyl peptidase 40011
Amine oxidase [flavin-containing] B0102
Voltage-dependent calcium channel subunit alpha-2/delta-10101
Voltage-dependent calcium channel subunit alpha-2/delta-20101
hemoglobin subunit beta1001
lethal(3)malignant brain tumor-like protein 1 isoform I1001
muscleblind-like protein 1 isoform 12002
caspase-1 isoform alpha precursor1001
DNA dC->dU-editing enzyme APOBEC-3F isoform a1001
DNA topoisomerase 10202
Chromaffin granule amine transporter0101
Synaptic vesicular amine transporter0213
Synaptic vesicular amine transporter0101
Adenylate cyclase type 60101
Adenylate cyclase type 3 0101
Adenylate cyclase type 90101
D(1) dopamine receptor0101
Adenylate cyclase type 80101
Adenylate cyclase type 70101
Adenylate cyclase type 20101
Adenylate cyclase type 40101
Cytochrome P450 2B10101
Type-1 angiotensin II receptor0101
C-X-C chemokine receptor type 30101
Amine oxidase [flavin-containing] A0001
Free fatty acid receptor 30011
Aurora kinase A0101
Carbonic anhydrase 0002
Carbonic anhydrase 0202
Carbonic anhydrase 0202
Carbonic anhydrase 0202
Carbonic anhydrase0202
Carbonic anhydrase0202
Beta-carbonic anhydrase 10202
Carbonic anhydrase 20202
Carbonic anhydrase, alpha family 0202
Carbonic anhydrase 0202
Delta carbonic anhydrase0202
D(2) dopamine receptor0101
Orexin receptor type 10101
Orexin receptor type 20101
Substance-K receptor0101
Cereblon isoform 40202
Prostaglandin G/H synthase 20101
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0303
DNA-binding protein Ikaros0001
DNA damage-binding protein 10112
Protein cereblon0214
Chain A, Pyridoxal kinase0101
Chain A, Pyridoxal Kinase0101
Phosphodiesterase 0202
Renin0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D 0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
Adenosine receptor A2a0101
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
Chitotriosidase-10101
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0101
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0101
Adenosine receptor A2b0001
Endochitinase B10101
Muscarinic acetylcholine receptor M20011
Cholesterol 24-hydroxylase0101
Cathepsin D 0101
Mucosa-associated lymphoid tissue lymphoma translocation protein 10101
Chain X, Thyroid hormone receptor beta-10022
Chain X, Thyroid hormone receptor beta-10022
serine/threonine-protein kinase PLK12002
Solute carrier organic anion transporter family member 1A40103
Nuclear receptor subfamily 1 group I member 20011
Transthyretin0103
Thyroid hormone receptor alpha0235
Thyroid hormone receptor beta0235
Proliferating cell nuclear antigen0202
Retinoic acid receptor RXR-alpha0022
Peroxisome proliferator-activated receptor gamma0044
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20002
Solute carrier organic anion transporter family member 1A30003
Solute carrier organic anion transporter family member 4C10102
Monocarboxylate transporter 80001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
Solute carrier organic anion transporter family member 1B10002
Chain A, Carbonic anhydrase 10101
Prolyl endopeptidase0101
Carbonic anhydrase-related protein 110001
Polyunsaturated fatty acid 5-lipoxygenase0101
Arachidonate 5-lipoxygenase-activating protein0101
Carbonic anhydrase 5A, mitochondrial0101
Carbonic anhydrase 20101
Carbonic anhydrase 0101
Cytochrome P450 2E10101
Cytochrome P450 4B10101
Cytochrome P450 3A50101
Cytochrome P450 2A70101
Cytochrome P450 3A70101
Cytochrome P450 2F10101
Cytochrome P450 2C180101
Cytochrome P450 4F80101
Cytochrome P450 4A110101
Cytochrome P450 4F30101
Cytochrome P450 4A220101
Vitamin D 25-hydroxylase0101
Cytochrome P450 2U10101
Cytochrome P450 2W10101
Cytochrome P450 2S10101
Cytochrome P450 3A43 0101
REST corepressor 30101
Genome polyprotein 0101
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
DNA repair protein RAD52 homolog isoform a0001
Lysozyme C-10101
Glycoprotein hormones alpha chain1001
Protein kinase C alpha type0101
Beta-glucuronidase0101
Protein kinase C delta type0101
Protein kinase C epsilon type0101
Protein kinase C zeta type0101
Protein kinase C gamma type0101
Protein kinase C beta type0101
DNA-dependent protein kinase catalytic subunit0101
Protein kinase C eta type0101
Calcium-dependent protein kinase 40101
Emopamil-binding protein-like0101
Protein kinase C theta type0101
Solute carrier organic anion transporter family member 4C10001
Solute carrier organic anion transporter family member 4A10001
Solute carrier organic anion transporter family member 1C10101
Solute carrier organic anion transporter family member 1B30001
Chain A, Trp Rna-binding Attenuation Protein0011
Chain K, Trp Rna-binding Attenuation Protein0011
Chain B, tryptophanyl-tRNA synthetase0011
Chain C, Tryptophanyl-tRNA synthetase II0011
Stromelysin-10101
Substance-P receptor0101
Tryptophan 2,3-dioxygenase0102
Tryprostatin B synthase0001
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase0011
Chain A, CHORISMATE MUTASE0101
Chain A, TYROSYL-tRNA SYNTHETASE0011
Tubulin--tyrosine ligase0101
Taste receptor type 2 member 140001
Urease subunit alpha0101
Urease subunit beta0101
M-phase inducer phosphatase 10101
Lysosomal alpha-glucosidase0101
pyruvate kinase PKM isoform a1001
tyrosine-protein kinase Yes1001
Ectonucleoside triphosphate diphosphohydrolase 10001
Solute carrier family 22 member 60001
Thymidine kinase, cytosolic0203
Protein kinase C beta type0101
DNA polymerase beta0101
Thymidine kinase, cytosolic 0001
Thymidylate kinase0101
Protein kinase C epsilon type0101
Thymidine kinase 0102
Thymidine kinase0102
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]