Compounds > triflumuron
Page last updated: 2024-12-06

triflumuron

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Triflumuron is an insecticide that belongs to the benzoylurea class. It acts as a chitin synthesis inhibitor, disrupting the development of insect exoskeletons and causing mortality. It is commonly used to control a wide range of insect pests, particularly in agriculture and public health. Triflumuron is synthesized via a multi-step process involving the reaction of benzoyl chloride with an appropriate amine. The synthesis typically involves the use of a catalyst and appropriate reaction conditions to optimize the yield and purity of the final product. The mode of action of triflumuron involves its interaction with chitin synthase, an enzyme responsible for the biosynthesis of chitin. Chitin is a major component of the insect exoskeleton, and by inhibiting its synthesis, triflumuron prevents insects from molting properly, leading to their death. Triflumuron has been extensively studied due to its effectiveness as an insecticide and its low mammalian toxicity. Research on triflumuron encompasses areas such as its efficacy against different insect pests, its environmental fate and persistence, and its potential for resistance development. The importance of studying triflumuron stems from its widespread use in pest control, the need to understand its environmental impact, and the potential for resistance development in target insect populations.'

triflumuron: insect growth inhibitor [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID47445
CHEMBL ID1394379
CHEBI ID39388
SCHEMBL ID23700
MeSH IDM0081793

Synonyms (55)

Synonym
bay-vi 7533
bay-sir 8514
einecs 264-980-3
benzamide, 2-chloro-n-(((4-(trifluoromethoxy)phenyl)amino)carbonyl)-
sir 8514
brn 2776684
epa pesticide chemical code 118201
triflumuron [iso]
alsystin
ai3-29368
2-chloro-n-(((4-(trifluoromethoxy)phenyl)amino)carbonyl)benzamide
alsystine
caswell no. 217c
oms 2015
mascot
2-chloro-n-({[4-(trifluoromethoxy)phenyl]amino}carbonyl)benzamide
2-chloro-n-{[4-(trifluoromethoxy)phenyl]carbamoyl}benzamide
triflumuron
CHEBI:39388 ,
1-(o-chlorobenzoyl)-3-(p-(trifluoromethoxy)phenyl)urea
64628-44-0
trifluron
NCGC00094568-02
NCGC00094568-01
SPECTRUM1505170
2-chloro-n-[[4-(trifluoromethoxy)phenyl]carbamoyl]benzamide
2-chloranyl-n-[[4-(trifluoromethyloxy)phenyl]carbamoyl]benzamide
2-chloro-n-[oxo-[4-(trifluoromethoxy)anilino]methyl]benzamide
A834834
C18615
tox21_301874
NCGC00255190-01
cas-64628-44-0
dtxsid5034355 ,
dtxcid3014355
3ft64dyg8k ,
unii-3ft64dyg8k
FT-0630748
AKOS015889501
SCHEMBL23700
CHEMBL1394379
triflumuron [mart.]
1-(2-chlorobenzoyl)-3-(4-trifluoromethoxyphenyl)urea
triflumuron [mi]
triflumuron, certified reference material, tracecert(r)
mfcd00072496
CCG-231010
benzamide, 2-chloro-n-[[[4-(trifluoromethoxy)phenyl]amino]carbonyl]-
triflumuron, pestanal(r), analytical standard
2-chloro-n-(4-(trifluoromethoxy)phenylcarbamoyl)benzamide
1-(2-chlorobenzoyl)-3-[4-(trifluoromethoxy)phenyl]urea
2-chloro-n-((4-(trifluoromethoxy)phenyl)carbamoyl)benzamide
AS-13364
Q1995523
E78670

Research Excerpts

Overview

Triflumuron (TFM) is a benzoyl phenyl urea insecticide belonging to the class of IGRs. It is commonly used in Tunisian agriculture to control crop pests and flies.

ExcerptReferenceRelevance
"Triflumuron (TFM) is a benzoyl phenyl urea insecticide belonging to the class of IGRs."( Mini-review highlighting toxic effects of triflumuron in insects and mammalian systems.
Abid-Essefi, S; Amara, I; Salem, IB; Souid, G; Timoumi, R, 2023)		1.9
"Triflumuron (TFM) is a benzoylurea insecticide commonly used in Tunisian agriculture and around the world to control crop pests and flies as a promising alternative to conventional insecticides for its arthropod specificity and low toxicity. "( Metabolism of triflumuron in the human liver: Contribution of cytochrome P450 isoforms and esterases.
Abid-Essefi, S; Buratti, FM; Dorne, JCM; Testai, E; Timoumi, R, 2019)		2.32

Toxicity

ExcerptReferenceRelevance
"The increased use of pesticides is the origin of multiple damages to the environment and to humans; thus, the search for new strategies to reduce or even protect the toxic effects caused by these synthetic products became a necessity."( Protective effects of fennel essential oil against oxidative stress and genotoxicity induced by the insecticide triflumuron in human colon carcinoma cells.
Abid-Essefi, S; Amara, I; Annabi, E; Salem, IB; Timoumi, R, 2020)		0.77
" Among those compounds, we focused our interest on triflumuron (TFM), which is less toxic than other conventional insecticides."( Triflumuron induces cytotoxic effects on hepatic and renal human cell lines.
Abid-Essefi, S; Amara, I; Ben Salem, I; Timoumi, R, 2020)		2.25
" As these compounds are potentially toxic to the target organisms, they could also be harmful to human health and the environment."( Mini-review highlighting toxic effects of triflumuron in insects and mammalian systems.
Abid-Essefi, S; Amara, I; Salem, IB; Souid, G; Timoumi, R, 2023)		1.17

Dosage Studied

ExcerptRelevanceReference
" albopictus was evaluated with laboratory strains through dose-response assays."( Effect of triflumuron, a chitin synthesis inhibitor, on Aedes aegypti, Aedes albopictus and Culex quinquefasciatus under laboratory conditions.
Belinato, TA; Lima, JB; Martins, AJ; Valle, D, 2013)		0.79
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (4)

ClassDescription
benzoylurea insecticide
monochlorobenzenesAny member of the class of chlorobenzenes containing a mono- or poly-substituted benzene ring in which only one substituent is chlorine.
organofluorine compoundAn organofluorine compound is a compound containing at least one carbon-fluorine bond.
aromatic etherAny ether in which the oxygen is attached to at least one aryl substituent.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (9)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency7.94330.004023.8416100.0000AID485290
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency4.10360.001022.650876.6163AID1224838; AID1224893
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency30.63790.003041.611522,387.1992AID1159552; AID1159555
pregnane X nuclear receptorHomo sapiens (human)Potency0.96890.005428.02631,258.9301AID1346982
estrogen nuclear receptor alphaHomo sapiens (human)Potency0.17230.000229.305416,493.5996AID743080
aryl hydrocarbon receptorHomo sapiens (human)Potency14.09680.000723.06741,258.9301AID743085; AID743122
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency2.16900.001723.839378.1014AID743083
activating transcription factor 6Homo sapiens (human)Potency0.00120.143427.612159.8106AID1159516
histone deacetylase 9 isoform 3Homo sapiens (human)Potency34.37620.037617.082361.1927AID1259364
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (15)

Assay IDTitleYearJournalArticle
AID1090606Larvicidal activity against Mythimna separata (Oriental armyworm) in compound treated corn leaves at 1 mg/L at 25 +/- 1 degC measured after 4 days2007Journal of agricultural and food chemistry, Apr-04, Volume: 55, Issue:7
Insecticidal benzoylphenylurea-S-carbamate: a new propesticide with two effects of both benzoylphenylureas and carbamates.
AID1080629Insecticidal activity against third-instar larval stage of Spodoptera exigua in cabbage leaves assessed as mortality at 25 +/-1degC treated for 5 secs before larval infestation measured after 4 days by leaf dip method2009Journal of agricultural and food chemistry, May-13, Volume: 57, Issue:9
Design, synthesis, and insecticidal activities of new N-benzoyl-N'-phenyl-N'-sulfenylureas.
AID1090609Larvicidal activity against Mythimna separata (Oriental armyworm) in compound treated corn leaves at 10 mg/L at 25 +/- 1 degC measured after 4 days2007Journal of agricultural and food chemistry, Apr-04, Volume: 55, Issue:7
Insecticidal benzoylphenylurea-S-carbamate: a new propesticide with two effects of both benzoylphenylureas and carbamates.
AID1090603Larvicidal activity against Mythimna separata (Oriental armyworm) in compound treated corn leaves at 100 mg/L at 25 +/- 1 degC measured after 4 days2007Journal of agricultural and food chemistry, Apr-04, Volume: 55, Issue:7
Insecticidal benzoylphenylurea-S-carbamate: a new propesticide with two effects of both benzoylphenylureas and carbamates.
AID1080637Insecticidal activity against fourth-instar larval stage of Mythimna separata (Oriental armyworm) in compound-pretreated corn leaves assessed as mortality at 2.5 mg/l at 25 +/-1degC after 4 days2009Journal of agricultural and food chemistry, May-13, Volume: 57, Issue:9
Design, synthesis, and insecticidal activities of new N-benzoyl-N'-phenyl-N'-sulfenylureas.
AID1090607Larvicidal activity against Mythimna separata (Oriental armyworm) in compound treated corn leaves at 2.5 mg/L at 25 +/- 1 degC measured after 4 days2007Journal of agricultural and food chemistry, Apr-04, Volume: 55, Issue:7
Insecticidal benzoylphenylurea-S-carbamate: a new propesticide with two effects of both benzoylphenylureas and carbamates.
AID1090605Larvicidal activity against Mythimna separata (Oriental armyworm ) in compound treated corn leaves at 0.5 mg/L at 25 +/- 1 degC measured after 4 days2007Journal of agricultural and food chemistry, Apr-04, Volume: 55, Issue:7
Insecticidal benzoylphenylurea-S-carbamate: a new propesticide with two effects of both benzoylphenylureas and carbamates.
AID1090604Larvicidal activity against Mythimna separata (Oriental armyworm) in compound treated corn leaves at 0.25 mg/L at 25 +/- 1 degC measured after 4 days2007Journal of agricultural and food chemistry, Apr-04, Volume: 55, Issue:7
Insecticidal benzoylphenylurea-S-carbamate: a new propesticide with two effects of both benzoylphenylureas and carbamates.
AID1080644Insecticidal activity against fourth-instar larval stage of Mythimna separata (Oriental armyworm) in compound-pretreated corn leaves assessed as mortality at 1 mg/l at 25 +/-1degC after 4 days2009Journal of agricultural and food chemistry, May-13, Volume: 57, Issue:9
Design, synthesis, and insecticidal activities of new N-benzoyl-N'-phenyl-N'-sulfenylureas.
AID1080630Insecticidal activity against larvae of Plutella xylostella (diamondback moth) in cabbage leaves assessed as mortality at 25 +/-1degC treated for 5 secs before larval infestation measured after 4 days by leafdip method2009Journal of agricultural and food chemistry, May-13, Volume: 57, Issue:9
Design, synthesis, and insecticidal activities of new N-benzoyl-N'-phenyl-N'-sulfenylureas.
AID1080643Insecticidal activity against fourth-instar larval stage of Mythimna separata (Oriental armyworm) in compound-pretreated corn leaves assessed as mortality at 0.5 mg/l at 25 +/-1degC after 4 days2009Journal of agricultural and food chemistry, May-13, Volume: 57, Issue:9
Design, synthesis, and insecticidal activities of new N-benzoyl-N'-phenyl-N'-sulfenylureas.
AID1080642Insecticidal activity against fourth-instar larval stage of Mythimna separata (Oriental armyworm) in compound-pretreated corn leaves assessed as mortality at 0.25 mg/l at 25 +/-1degC after 4 days2009Journal of agricultural and food chemistry, May-13, Volume: 57, Issue:9
Design, synthesis, and insecticidal activities of new N-benzoyl-N'-phenyl-N'-sulfenylureas.
AID1090611Larvicidal activity against Mythimna separata (Oriental armyworm) in compound treated corn leaves at 50 mg/L at 25 +/- 1 degC measured after 4 days2007Journal of agricultural and food chemistry, Apr-04, Volume: 55, Issue:7
Insecticidal benzoylphenylurea-S-carbamate: a new propesticide with two effects of both benzoylphenylureas and carbamates.
AID1090608Larvicidal activity against Mythimna separata (Oriental armyworm) in compound treated corn leaves at 5 mg/L at 25 +/- 1 degC measured after 4 days2007Journal of agricultural and food chemistry, Apr-04, Volume: 55, Issue:7
Insecticidal benzoylphenylurea-S-carbamate: a new propesticide with two effects of both benzoylphenylureas and carbamates.
AID1090610Larvicidal activity against Mythimna separata (Oriental armyworm) in compound treated corn leaves at 25 mg/L at 25 +/- 1 degC measured after 4 days2007Journal of agricultural and food chemistry, Apr-04, Volume: 55, Issue:7
Insecticidal benzoylphenylurea-S-carbamate: a new propesticide with two effects of both benzoylphenylureas and carbamates.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (68)

TimeframeStudies, This Drug (%)All Drugs %
pre-199018 (26.47)18.7374
1990's11 (16.18)18.2507
2000's16 (23.53)29.6817
2010's16 (23.53)24.3611
2020's7 (10.29)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 39.24

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index39.24 (24.57)
Research Supply Index4.29 (2.92)
Research Growth Index4.62 (4.65)
Search Engine Demand Index62.36 (26.88)
Search Engine Supply Index2.27 (0.95)

This Compound (39.24)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (1.41%)5.53%
Reviews2 (2.82%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other68 (95.77%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
carbamates
[no description available]		2.3820amino-acid anion
carbon monoxide
Carbon Monoxide: Carbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, which has no oxygen carrying capacity. The resultant oxygen deprivation causes headache, dizziness, decreased pulse and respiratory rates, unconsciousness, and death. (From Merck Index, 11th ed). carbon monoxide : A one-carbon compound in which the carbon is joined only to a single oxygen. It is a colourless, odourless, tasteless, toxic gas.		2.0710carbon oxide;
gas molecular entity;
one-carbon compound		biomarker;
EC 1.9.3.1 (cytochrome c oxidase) inhibitor;
human metabolite;
ligand;
metabolite;
mitochondrial respiratory-chain inhibitor;
mouse metabolite;
neurotoxin;
neurotransmitter;
P450 inhibitor;
probe;
signalling molecule;
vasodilator agent
glycine
[no description available]		2.1510alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid		EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical
methanol
Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.. primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.. methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.		2.110alkyl alcohol;
one-carbon compound;
primary alcohol;
volatile organic compound		amphiprotic solvent;
Escherichia coli metabolite;
fuel;
human metabolite;
mouse metabolite;
Mycoplasma genitalium metabolite
urea
pseudourea: clinical use; structure. isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.		2.4120isourea;
monocarboxylic acid amide;
one-carbon compound		Daphnia magna metabolite;
Escherichia coli metabolite;
fertilizer;
flour treatment agent;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
diazinon
Diazinon: A cholinesterase inhibitor that is used as an organothiophosphorus insecticide.. diazinon : A member of the class of pyrimidines that is pyrimidine carrying an isopropyl group at position 2, a methyl group at position 6 and a (diethoxyphosphorothioyl)oxy group at position 4.		1.9710organic thiophosphate;
pyrimidines		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
environmental contaminant;
nematicide;
xenobiotic
malathion
Malathion: A wide spectrum aliphatic organophosphate insecticide widely used for both domestic and commercial agricultural purposes.. malathion : A racemate comprising equimolar amounts of (R) and (S)-malathion. It is a broad spectrum organophosphate proinsecticide used to control a wide range of pests including Coleoptera, Diptera, fruit flies, mosquitos and spider mites.. diethyl 2-[(dimethoxyphosphorothioyl)thio]succinate : A diester that is diethyl succinate in which position 2 is substituted by a (dimethoxyphosphorothioyl)thio group.		2.1510diester;
ethyl ester;
organic thiophosphate
methomyl
Methomyl: A carbamate insecticide with anticholinesterase activity.. methomyl : A carbamate ester obtained by the formal condensation of methylcarbamic acid with the hydroxy group of 1-(methylsulfanyl)acetaldoxime.		2.0310aliphatic sulfide;
carbamate ester		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
environmental contaminant;
insecticide;
nematicide;
xenobiotic
phosalone
phosalone: structure. phosalone : A member of the class of 1,3-benzoxazoles carrying a [(diethoxyphosphorothioyl)sulfanyl]methyl group at the nitrogen atom, an oxo group at position 2 and a chloro group at position 6. It is an organothiophosphate insecticide.		2.03101,3-benzoxazoles;
carbamate ester;
organochlorine insecticide;
organothiophosphate insecticide		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor
temefos
Temefos: An organothiophosphate insecticide.. temephos : An organic sulfide that is diphenyl sulfide in which the hydrogen at the para position of each of the phenyl groups has been replaced by a (dimethoxyphosphorothioyl)oxy group.		2.0410organic sulfide;
organic thiophosphate;
organothiophosphate insecticide		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
ectoparasiticide
carbaryl
Carbaryl: A carbamate insecticide and parasiticide. It is a potent anticholinesterase agent belonging to the carbamate group of reversible cholinesterase inhibitors. It has a particularly low toxicity from dermal absorption and is used for control of head lice in some countries.. carbaryl : A carbamate ester obtained by the formal condensation of 1-naphthol with methylcarbamic acid.		1.9710carbamate ester;
naphthalenes		acaricide;
agrochemical;
carbamate insecticide;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
plant growth retardant
phencyclidine
Phencyclidine: A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.. phencyclidine : A member of the class of piperidines that is piperidine in which the nitrogen is substituted with a 1-phenylcyclohexyl group. Formerly used as an anaesthetic agent, it exhibits both hallucinogenic and neurotoxic effects.		1.9710benzenes;
piperidines		anaesthetic;
neurotoxin;
NMDA receptor antagonist;
psychotropic drug
citronellal
citronellal: aldehyde of citronellol; found in citronella oil. citronellal : A monoterpenoid, the main component of citronella oil which gives it its distinctive lemon aroma.		3.0910aldehyde;
monoterpenoid		antifungal agent;
metabolite
oxazoles
Oxazoles: Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.. 1,3-oxazole : A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.. oxazole : An azole based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom.		2.03101,3-oxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
thiazoles
[no description available]		2.1101,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
thiazolidines
Thiazolidines: Reduced (protonated) form of THIAZOLES. They can be oxidized to THIAZOLIDINEDIONES.		1.9910thiazolidine
chlorobenzilate
chlorobenzilate: structure		1.9710diarylmethane
luminol
Luminol: 5-Amino-2,3-dihydro-1,4-phthalazinedione. Substance that emits light on oxidation. It is used in chemical determinations.		2.0410
malondialdehyde
Malondialdehyde: The dialdehyde of malonic acid.. malonaldehyde : A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form.		2.2110dialdehydebiomarker
precocene ii
precocene II: has antibacterial, antifungal, insecticidal, and antioxidant activities; from plants of genus Ageratum; an antiallotropin compound capable of inhibiting juvenile hormone biosynthesis		210chromenesprecocenes
palladium
Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.		2.0710metal allergen;
nickel group element atom;
platinum group metal atom
acetylglucosamine
Acetylglucosamine: The N-acetyl derivative of glucosamine.. N-acetyl-beta-D-glucosamine : An N-acetyl-D-glucosamine having beta-configuration at the anomeric centre.		2.0310N-acetyl-D-glucosamineepitope
diflubenzuron
Diflubenzuron: An insect growth regulator which interferes with the formation of the insect cuticle. It is effective in the control of mosquitoes and flies.. diflubenzuron : A benzoylurea insecticide that is urea in which a hydrogen attached to one of the nitrogens is replaced by a 4-chlorophenyl group, and a hydrogen attached to the other nitrogen is replaced bgy a 2,6-difluorobenzoyl group.		10.4190benzoylurea insecticide;
monochlorobenzenes		insect sterilant
cyromazine
cyromazine: RN given refers to parent cpd		2.4220triamino-1,3,5-triazinemouse metabolite;
triazine insecticide
buprofezin
buprofezin: tradename - Applaud; used for the control of homopterous insect pests; structure given in first source. (E)-buprofezin : A 2-(tert-butylimino)-5-phenyl-3-(propan-2-yl)-1,3,5-thiadiazinan-4-one in which the C=N double bond has E configuration.. buprofezin : A 2-(tert-butylimino)-5-phenyl-3-(propan-2-yl)-1,3,5-thiadiazinan-4-one in which the C=N double bond has Z configuration.		2.610thiadiazinane;
ureas
fenoxycarb
fenoxycarb: used against mosquitoes (Diptera:Culicidae); structure given in first source. fenoxycarb : A carbamate ester that is the O-ethyl carbamate of 2-(4-phenoxyphenoxy)ethylamine.		2.3820aromatic ether;
carbamate ester		environmental contaminant;
insecticide;
juvenile hormone mimic;
xenobiotic
triazoles
Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.		2.15101,2,3-triazole
fluphenacur
fluphenacur: RN given refers to parent cpd		2.7330aromatic ether;
benzoylurea insecticide;
dichlorobenzene;
N-acylurea;
organofluorine compound
clofentezine
clofentezine: acaricide, primarily a mite ovicide; structure given in first source. clofentezine : A tetrazine that is 1,2,4,5-tetrazine in which both of the hydrogens have been replaced by o-chlorophenyl groups.		1.9910monochlorobenzenes;
organochlorine acaricide;
tetrazine		mite growth regulator;
tetrazine acaricide
sulfluramid
sulfluramid: delayed-action insecticide against the cockroach Dyctyoptera; Blattelidae germanica. sulfluramid : A sulfonamide obtained by the formal condensation of perfluorooctane-1-sulfonic acid with ethylamine.		2.0810sulfonamideacaricide;
environmental contaminant;
insecticide;
xenobiotic
tebuconazole
Lynx: A genus in the family FELIDAE comprising felines with long legs, ear tufts, and a short tail.. 1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol : A tertiary alcohol that is pentan-3-ol substituted by a 4-chlorophenyl, methyl, methyl, and a 1H-1,2,4-triazol-1-ylmethyl at positions 1, 4, 4 and 3 respectively.. tebuconazole : A racemate composed of equimolar amounts of (R)- and (S)-tebuconazole. A fungicide effective against various smut and bunt diseases in cereals and other field crops.		2.1510monochlorobenzenes;
tertiary alcohol;
triazoles
pencycuron
pencycuron: structure given in first source. pencycuron : A member of the class of phenylureas that is urea which is substituted by p-chlorobenzyl and cyclopentyl groups at position 1 and a phenyl group at position 3. A fungicide used to control diseases caused by Rhizoctonia solani and Pellicularia spp. It is not highly toxic to mammals but is moderately toxic to birds, most aquatic organisms, honeybees and earthworms.		2.2110monochlorobenzenes;
phenylureas		antifungal agrochemical
chlorfluazuron
chlorfluazuron: chitin synthesis inhibitor		3.0750benzoylurea insecticide;
dichlorobenzene;
organochlorine insecticide;
organofluorine insecticide
teflubenzuron
teflubenzuron: effective against development of house fly larvae (Musca domestica). teflubenzuron : A N-acylurea that is N-carbamoyl-2,6-difluorobenzamide substituted by a 3,5-dichloro-2,4-difluorophenyl group at the terminal nitrogen atom.		7.9140dichlorobenzene;
difluorobenzene;
N-acylurea		environmental contaminant;
insecticide;
xenobiotic
hexafluoron
hexafluoron: insect growth regulator against mosquito larva; the active agent in Sonet, a Russian product, is hexaflumuron. hexaflumuron : An N-acylurea that is urea in which a hydrogen attached to one of the nitrogens is replaced by a 2,6-difluorobenzoyl group, while a hycrogen attached to the other nitorgen is replaced by a 3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)phenyl group.		3.2760aromatic ether;
benzoylurea insecticide;
dichlorobenzene;
N-acylurea;
organochlorine insecticide;
organofluorine insecticide
pyriproxyfen
pyriproxyfen: an insect growth regulator; RN given refers to cpd without isomeric designation. pyriproxyfen : An aromatic ether that consists of propylene glycol having a 2-pyridyl group at the O-1 position and a 4-phenoxyphenyl group at the O-3 position.		7.3110aromatic ether;
pyridines		juvenile hormone mimic
flufenoxuron
[no description available]		2.9640(trifluoromethyl)benzenes;
benzoylurea insecticide;
difluorobenzene;
monochlorobenzenes;
monofluorobenzenes		mite growth regulator
novaluron
novaluron: insecticide		2.610aromatic ether;
benzoylurea insecticide;
monochlorobenzenes;
organofluorine compound
j 2644
[no description available]		1.9710
thiamethoxam
Thiamethoxam: A nitro-oxazine and thiazole derivative that is used as a broad spectrum neonicotinoid insecticide.. thiamethoxam : An oxadiazane that is tetrahydro-N-nitro-4H-1,3,5-oxadiazin-4-imine bearing (2-chloro-1,3-thiazol-5-yl)methyl and methyl substituents at positions 3 and 5 respectively.		2.1101,3-thiazoles;
2-nitroguanidine derivative;
organochlorine compound;
oxadiazane		antifeedant;
carcinogenic agent;
environmental contaminant;
neonicotinoid insectide;
xenobiotic
penfluron
[no description available]		2.940
borneo
Borneo: An island in the Malay Archipelago, east of Sumatra, north of Java, and west of Celebes. It is the third largest island in the world. Its name is a Portuguese alteration of BRUNEI, located on it. (From Webster's New Geographical Dictionary, 1988, p163; Room, Brewer's Dictionary of Names, 1992, p73)		2.0310organofluorine acaricide
potassium permanganate
Potassium Permanganate: Permanganic acid (HMnO4), potassium salt. A highly oxidative, water-soluble compound with purple crystals, and a sweet taste. (From McGraw-Hill Dictionary of Scientific and Technical Information, 4th ed)		2.0410
1-octyl-3-methylimidazolium hexafluorophosphate
1-octyl-3-methylimidazolium hexafluorophosphate: is a nonaqueous ionic liquid		2.110
dicyclanil
[no description available]		7.0810
cyhalothrin
cyhalothrin: acaricidal & insecticidal synthetic pyrethroid; structure given in first source. cyhalothrin : A carboxylic ester obtained by formal condensation between 3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylic acid and cyano(3-phenoxyphenyl)methanol.		2.110aromatic ether;
cyclopropanecarboxylate ester;
nitrile;
organochlorine compound;
organofluorine compound		agrochemical;
pyrethroid ester acaricide;
pyrethroid ester insecticide
methoprene
Methoprene: Juvenile hormone analog and insect growth regulator used to control insects by disrupting metamorphosis. Has been effective in controlling mosquito larvae.		3.4920isopropyl 11-methoxy-3,7,11-trimethyldodeca-2,4-dienoate;
isopropyl ester		juvenile hormone mimic
zr-512
ethyl-3,7,11-trimethyl-2,4-dodecadienoate: an insect growth regulator; RN given refers to (E,E)-isomer. hydroprene : The ethyl ester of (2E,4E)-3,7,11-trimethyldodeca-2,4-dienoic acid		3.4920ethyl ester;
farnesane sesquiterpenoid		juvenile hormone mimic
5-fluoro-1,3-dimethyl-N-[2-(4-methylpentan-2-yl)phenyl]pyrazole-4-carboxamide
penflufen: Fungicides, Industrial. penflufen : A racemate comprising equimolar amounts of (R)- and (S)-penflufen. A fungicide used in furrow and seed piece treatment use on potatoes and as a seed treatment for legume vegetables, cereal grains, oil seeds and alfalfa.. 5-fluoro-1,3-dimethyl-N-[2-(4-methylpentan-2-yl)phenyl]pyrazole-4-carboxamide : An aromatic amide obtained by formal condensation of the carboxy group of 5-fluoro-1,3-dimethylpyrazole-4-carboxylic acid with the amino group of 2-(4-methylpentan-2-yl)aniline.		2.2110aromatic amide;
organofluorine compound;
pyrazoles
pyrethrins
[no description available]		2.110
ConditionIndicatedRelationship StrengthStudiesTrials
Cancer of Colon
[description not available]		02.2510
Colonic Neoplasms
Tumors or cancer of the COLON.		02.2510
Break-Bone Fever
[description not available]		02.110
Dengue
An acute febrile disease transmitted by the bite of AEDES mosquitoes infected with DENGUE VIRUS. It is self-limiting and characterized by fever, myalgia, headache, and rash. SEVERE DENGUE is a more virulent form of dengue.		02.110
Pediculosis
[description not available]		04.131
Lice Infestations
Parasitic attack or subsistence on the skin by members of the order Phthiraptera, especially on humans by Pediculus humanus of the family Pediculidae. The hair of the head, eyelashes, and pubis is a frequent site of infestation. (From Dorland, 28th ed; Stedman, 26th ed)		04.131
Carcinoma, Epidermoid
[description not available]		02.0510
Cancer of Skin
[description not available]		02.0510
Carcinoma, Squamous Cell
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)		02.0510
Skin Neoplasms
Tumors or cancer of the SKIN.		02.0510
Equine Diseases
[description not available]		03.4211
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		01.9610
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		01.9910
Poultry Diseases
Diseases of birds which are raised as a source of meat or eggs for human consumption and are usually found in barnyards, hatcheries, etc. The concept is differentiated from BIRD DISEASES which is for diseases of birds not considered poultry and usually found in zoos, parks, and the wild.		02.9110
Acariasis
[description not available]		02.9110
Maggot Infestations
[description not available]		01.9910
Ovine Diseases
[description not available]		02.3820
Trichostrongylosis
Infestation with nematode worms of the genus TRICHOSTRONGYLUS. Man and animals become infected by swallowing larvae, usually with contaminated food or drink, although the larvae may penetrate human skin.		01.9610
Ostertagiasis
A disease of herbivorous mammals, particularly cattle and sheep, caused by stomach worms of the genus OSTERTAGIA.		01.9610
Haemonchiasis
Infection with nematodes of the genus HAEMONCHUS, characterized by digestive abnormalities and anemia similar to that from hookworm infestation.		01.9610