novaluron: insecticide [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 93541 |
| CHEMBL ID | 1869031 |
| CHEBI ID | 39385 |
| SCHEMBL ID | 26984 |
| MeSH ID | M0446511 |
| Synonym |
|---|
| n-({3-chloro-4-[1,1,2-trifluoro-2-(trifluoromethoxy)ethoxy]phenyl}carbamoyl)-2,6-difluorobenzamide |
| 116714-46-6 |
| n-[({3-chloro-4-[1,1,2-trifluoro-2-(trifluoromethoxy)ethoxy]phenyl}amino)carbonyl]-2,6-difluorobenzamide |
| rimon |
| CHEBI:39385 , |
| novaluron |
| NCGC00163902-01 |
| benzamide, n-3-chloro-4-(1,1,2-trifluoro)-2-(trifluoromethoxy)ethoxyphenyl-amino-carbonyl-2,6-difluoro- |
| novaluron [iso] |
| hsdb 7004 |
| benzamide, n-(((3-chloro-4-(1,1,2-trifluoro-2-(trifluoromethoxy)ethoxy)phenyl)amino)carbonyl)-2,6-difluoro- |
| NCGC00163902-02 |
| AKOS005063565 |
| n-[[3-chloro-4-[1,1,2-trifluoro-2-(trifluoromethoxy)ethoxy]phenyl]carbamoyl]-2,6-difluorobenzamide |
| NCGC00163902-04 |
| NCGC00163902-03 |
| C18875 |
| dtxcid3014773 |
| tox21_300959 |
| cas-116714-46-6 |
| NCGC00254861-01 |
| dtxsid5034773 , |
| unii-z8h1b3cw0b |
| 1-(3-chloro-4-(1,1,2-trifluoro-2-trifluoromethoxyethoxy)phenyl)-3-(2,6-difluorobenzoyl)urea |
| rimon ec-10 |
| z8h1b3cw0b , |
| 1-[3-chloro-4-(1,1,2-trifluoro-2-trifluoromethoxyethoxy)phenyl]-3-(2,6-difluorobenzoyl)urea |
| FT-0631085 |
| CHEMBL1869031 |
| S5475 |
| diamond (insecticide) |
| pedestal |
| benzamide, n-3-chloro-4-(1,1,2-trifluoro)-2- (trifluoromethoxy)ethoxyphenyl-amino-carbonyl-2,6-difluoro- |
| benzamide, n-(((3-chloro-4-(1,1,2-trifluoro-2- (trifluoromethoxy)ethoxy)phenyl)amino)carbonyl)-2,6- difluoro- |
| rimon [hsdb] |
| novaluron [mi] |
| oscar 10ce |
| CS-3305 |
| HY-17519 |
| SCHEMBL26984 |
| benzamide, n-[[[3-chloro-4-[1,1,2-trifluoro-2-(trifluoromethoxy)ethoxy]phenyl]amino]carbonyl]-2,6-difluoro- |
| novaluron, pestanal(r), analytical standard |
| mfcd04112632 |
| n-(3-chloro-4-(1,1,2-trifluoro-2-(trifluoromethoxy)ethoxy)phenylcarbamoyl)-2,6-difluorobenzamide |
| n-((3-chloro-4-(1,1,2-trifluoro-2-(trifluoromethoxy)ethoxy)phenyl)carbamoyl)-2,6-difluorobenzamide |
| AS-15773 |
| Q1900206 |
| AMY12537 |
| BCP33320 |
| CCG-269636 |
Novaluron is an insect growth regulator (IGR) used against fruit-borers and domestic pests. It is a benzoylphenylurea (BPU) that acts as a chitin synthesis inhibitor, already used against mosquitoes.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Novaluron has no cross-resistance with other leading compounds for controlling whiteflies such as buprofezin and pyriproxyfen." | ( Novaluron (Rimon), a novel IGR--mechanism, selectivity and importance in IPM programs. Barazani, A; Horowitz, AR; Ishaaya, I; Tirry, L, 2002) | 2.48 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "Novaluron at lower dose (0.5 microg l(-1)) was not effective, but at 0.75 microg and higher concentrations it elicited results comparable to those of vitamin A." | ( Developmental disruptions induced by insect growth regulator (Novaluron) in Bufo melanostictus tadpoles. Deshpande, PA; Ghodageri, M; Javalkar, R; Pancharatna, K, 2010) | 1.32 |
Novaluron treatment caused ultrastructural changes in the ovaries of 1-day-old adults (48 h post exposure), distorting the follicular epithelial cell architecture of developing oocytes.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Novaluron treatment caused ultrastructural changes in the ovaries of 1-day-old adults (48 h post exposure), distorting the follicular epithelial cell architecture of developing oocytes." | ( Novaluron prevents oogenesis and oviposition by inducing ultrastructural changes in ovarian tissue of young adult Lygus lineolaris. Anderson, CJ; Catchot, B; Gore, J; Jackson, R; Krishnan, N; Musser, F; Rakshit, K, 2020) | 2.72 |
| "Novaluron treatment inhibited adult emergence, induced immature mortality, altered adult sex ratio and caused delay in larval development." | ( Physiological and morphological aspects of Aedes aegypti developing larvae: effects of the chitin synthesis inhibitor novaluron. Brito, JM; Farnesi, LC; Linss, JG; Pelajo-Machado, M; Rezende, GL; Valle, D, 2012) | 1.31 |
Novaluron mortality in all novaluron provision dosing treatments was significantly higher than the water or blank controls. Novaluron is toxic to progeny in nest cells.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Field trials to identify the optimum field dosage of Novaluron against Anopheles mosquitoes were carried out under semi-natural conditions in artificial plots and in vessels with wild mosquitoes." | ( Effect of Novaluron (Rimon 10 EC) on the mosquitoes Anopheles albimanus, Anopheles pseudopunctipennis, Aedes aegypti, Aedes albopictus and Culex quinquefasciatus from Chiapas, Mexico. Arredondo-Jiménez, JI; Valdez-Delgado, KM, 2006) | 0.98 |
| " rotundata mortality in all novaluron provision dosing treatments was significantly higher than the water or blank controls, providing evidence that novaluron is toxic to progeny in nest cells." | ( Effects of the insect growth regulator, novaluron on immature alfalfa leafcutting bees, Megachile rotundata. Barbour, JD; Hodgson, EW; Pitts-Singer, TL, 2011) | 0.93 |
| " Both a glass vial bioassay and a diet-incorporated bioassay used dose-response regression lines to calculate LC(50) and LC(90) values for novaluron." | ( Baseline Susceptibility of Lygus lineolaris (Hemiptera: Miridae) to Novaluron. Allen, KC; Little, NS; Luttrell, RG; Parys, KA; Snodgrass, GL, 2016) | 0.87 |
| " The optimum field dosage was 2 ppm and the residual effect was 28 days." | ( Use of Novaluron-Based Autocidal Gravid Ovitraps to Control Gunawardene, YS; Hapugoda, MD; Viswakula, SD; Withanage, GP, 2020) | 1.01 |
| Class | Description |
|---|---|
| benzoylurea insecticide | |
| monochlorobenzenes | Any member of the class of chlorobenzenes containing a mono- or poly-substituted benzene ring in which only one substituent is chlorine. |
| aromatic ether | Any ether in which the oxygen is attached to at least one aryl substituent. |
| organofluorine compound | An organofluorine compound is a compound containing at least one carbon-fluorine bond. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| AR protein | Homo sapiens (human) | Potency | 26.8325 | 0.0002 | 21.2231 | 8,912.5098 | AID743053 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 21.4552 | 0.0002 | 29.3054 | 16,493.5996 | AID743075; AID743078 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 25.1189 | 0.0100 | 39.5371 | 1,122.0200 | AID588545 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 33.4915 | 0.0023 | 19.5956 | 74.0614 | AID651631 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1112025 | Insecticidal activity against Drosophila suzukii assessed as mortality at 212.5 g/ha by direct application at 22 degC measured after 24 hr | 2011 | Pest management science, Nov, Volume: 67, Issue:11 | Laboratory and field comparisons of insecticides to reduce infestation of Drosophila suzukii in berry crops. |
| AID1081236 | Insecticidal activity against Bemisia tabaci (sweet potato whitefly) nymphs assessed as suppression of larval pupation at 0.3 mg of ai/ha | 2010 | Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5 | Synthesis and insecticidal activity of heptafluoroisopropyl-containing benzoylphenylurea structures. |
| AID1112206 | Insecticidal activity against po dosed Cydia pomonella (codling moth) lab-s neonate measured after 4 days | 2012 | Pest management science, Jun, Volume: 68, Issue:6 | Development of a rapid resistance monitoring bioassay for codling moth larvae. |
| AID1081246 | Insecticidal activity against Spodoptera littoralis worm third-instar larvae grown on compound pre-treated caster bean leaves assessed as larval mortality at 0.5 mg of ai/L as Rimon EC formulation measured 4 days post compound treatment | 2010 | Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5 | Synthesis and insecticidal activity of heptafluoroisopropyl-containing benzoylphenylurea structures. |
| AID1081243 | Insecticidal activity against Spodoptera littoralis worm third-instar larvae grown on compound pre-treated caster bean leaves assessed as larval mortality at 0.5 mg of ai/L as Rimon EC formulation measured 8 days post compound treatment | 2010 | Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5 | Synthesis and insecticidal activity of heptafluoroisopropyl-containing benzoylphenylurea structures. |
| AID1081240 | Insecticidal activity against Spodoptera littoralis worm third-instar larvae grown on compound pre-treated caster bean leaves assessed as larval weight gain at 0.5 mg of ai/L as Rimon EC formulation measured 8 days post compound treatment relative to untr | 2010 | Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5 | Synthesis and insecticidal activity of heptafluoroisopropyl-containing benzoylphenylurea structures. |
| AID1112205 | Insecticidal activity against po dosed fourth-instar larvae of Cydia pomonella (codling moth) lab-s measured after 4 days | 2012 | Pest management science, Jun, Volume: 68, Issue:6 | Development of a rapid resistance monitoring bioassay for codling moth larvae. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 17 (22.67) | 29.6817 |
| 2010's | 37 (49.33) | 24.3611 |
| 2020's | 21 (28.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.
| This Compound (39.23) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 76 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||