Compounds > sulfometuron methyl
Page last updated: 2024-12-06

sulfometuron methyl

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Description

Sulfometuron methyl is a sulfonylurea herbicide that inhibits acetolactate synthase (ALS), an enzyme essential for the biosynthesis of branched-chain amino acids in plants. It is widely used for the control of broadleaf weeds in various crops, including cereals, cotton, and soybeans. The compound is synthesized via a multi-step process involving the reaction of a sulfonyl chloride with a substituted aniline followed by methylation. Sulfometuron methyl is known to exhibit high selectivity for certain plant species due to differences in the sensitivity of their ALS enzymes. Its effectiveness is influenced by factors such as soil type, temperature, and moisture. It is also reported to have residual activity, persisting in the soil for a period of time. Research on sulfometuron methyl focuses on understanding its mode of action, its environmental fate, and its potential for resistance development in weeds. The study of its environmental impact includes examining its persistence in soil and water, its potential for leaching, and its toxicity to non-target organisms. Resistance studies aim to identify the mechanisms of resistance and develop strategies for managing resistance in weed populations.'

sulfometuron methyl: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

sulfometuron methyl : A benzoate ester that is the methyl ester of 2-{[(4,6-dimethylpyrimidin-2-yl)carbamoyl]sulfamoyl}benzoic acid. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID52997
CHEMBL ID513261
CHEBI ID9348
SCHEMBL ID54998
MeSH IDM0124381

Synonyms (63)

Synonym
brn 0965602
sulfometuron-methyl
caswell no. 561d
einecs 277-780-6
epa pesticide chemical code 122001
1sm ,
methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate
methyl-2-(((((4,6-dimethyl-2-pyrimidinyl)amino)carbonyl)amino)sulfonyl)benzoate
dpx 5648
2-[3-(4,6-dimethylpyrimidin-2-yl)ureidosulfonyl]benzoic acid methyl ester
dpx-t5648
aa 5648
methyl 2-(((((4,6-dimethyl-2-pyrimidinyl)amino)carbonyl)amino)sulphonyl)benzoate
oust
benzoic acid, o-((3-(4,6-dimethyl-2-pyrimidinyl)ureido)sulfonyl)-, methyl ester
methyl-2-((((4,6-dimethyl-2-pyrimidinyl)amino)carbonyl)sulfonyl)benzoate (9ci)
o-((3-(4,6-dimethyl-2-pyrimidinyl)ureido)sulfonyl)-benzoic acid methyl ester
benzoic acid, 2-[[[[(4,6-dimethyl-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]-, methyl ester
C10955
74222-97-2
sulfometuron methyl
methyl-2-((((4,6-dimethyl-2-pyrimidinyl)amino)carbonyl)sulfonyl)benzoate
methyl 2-[(4,6-dimethylpyrimidin-2-yl)carbamoylsulfamoyl]benzoate
sulphometuron methyl
CHEMBL513261
chebi:9348 ,
A838066
methyl 2-[(4,6-dimethylpyrimidin-2-yl)carbamoylsulfamoyl]benzoate;sulfometuron methyl ester
benzoic acid, 2-(((((4,6-dimethyl-2-pyrimidinyl)amino)carbonyl)amino)sulfonyl)-, methyl ester
unii-jly5d60j1a
sulfometuron-methyl [iso]
5-25-10-00233 (beilstein handbook reference)
jly5d60j1a ,
hsdb 7732
tox21_301843
dtxsid0034936 ,
dtxcid8014936
NCGC00255670-01
cas-74222-97-2
sulfometuron methyl ester
FT-0630832
AKOS015897343
bdbm50424588
SCHEMBL54998
MG-0213
sulfometuron-methyl [mi]
2-(3-(4,6-dimethylpyrimidin-2-yl)ureidosulfonyl)benzoic acid methyl ester
sulfometuron-methyl [hsdb]
dpx-5648
n-[(4,6-dimethylpyrimidin-2-yl)aminocarbonyl]-2-methoxycarbonylbenzenesulfonamide
2-[[(4,6-dimethylpyrimidin-2-yl)aminocarbonyl]aminosulfonyl]benzoic acid, methyl ester
methyl 2-{[(4,6-dimethylpyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate
methyl 2-[(([(4,6-dimethyl-2-pyrimidinyl)amino]carbonyl)amino)sulfonyl]benzoate #
sulfometuron methyl, pestanal(r), analytical standard
sulfometuron methyl, analytical standard
methyl 2-(n-(4,6-dimethylpyrimidin-2-ylcarbamoyl)sulfamoyl)benzoate
mfcd00128060
Q23012061
AMY37128
methyl 2-(n-((4,6-dimethylpyrimidin-2-yl)carbamoyl)sulfamoyl)benzoate
dxp5648
dxp 5648
dxp-5648

Research Excerpts

Overview

Sulfometuron methyl (SM) is a widely used herbicide. SM is a potent inhibitor of acetolactate synthase II in Salmonella typhimurium.

ExcerptReferenceRelevance
"Sulfometuron methyl (SM) is a widely used herbicide and thus leading to accumulation in the environment. "( Effects of sulfometuron-methyl on zebrafish at early developmental stages.
Guo, J; Jia, K; Liu, W; Liu, Z; Lu, H; Lu, W; Luo, Q; Ma, F; Ma, J; Meng, Y; Peng, Y; Tian, G; Wei, F; Wei, Y; Wu, Z; Xu, Z; Yuan, W; Zhang, H; Zhu, Z, 2021)		2.06
"Sulfometuron methyl is a potent and specific inhibitor of acetolactate synthase II in Salmonella typhimurium. "( Sensitivity of a Salmonella typhimurium aspC mutant to sulfometuron methyl, a potent inhibitor of acetolactate synthase II.
LaRossa, RA; Van Dyk, TK, 1986)		1.96

Bioavailability

ExcerptReferenceRelevance
" Biochar is known to enhance soil quality but can also have undesired effects such as altering the bioavailability and behavior of herbicides."( Sorption-desorption and biodegradation of sulfometuron-methyl and its effects on the bacterial communities in Amazonian soils amended with aged biochar.
Campos Cedano, JC; de Souza Falcão, NP; Dunfield, K; Fonseca de Souza, L; Mendes, KF; Obregón Alvarez, D; Tornisielo, VL; Tosi, M; Tsai, SM, 2021)		0.62
"The speed of the sorption reaction alters the bioavailability of herbicides in the soil and, consequently, the transport and transformation processes of the molecule in the environment."( Sorption kinetics of sulfometuron-methyl in different Brazilian soils.
das Chagas, PSF; Freitas Souza, M; Jesus Passos, ABR; Lins, HA; Pavão, QS; Pereira, RKV; Silva, DV; Silva, TS, 2021)		0.62

Dosage Studied

ExcerptRelevanceReference
" Recent work has shown that changes in the gene dosage of this factor can dramatically alter the ability of a cell to tolerate a host of toxic agents including cadmium, cycloheximide, and sulfometuron methyl."( Transcriptional activation mediated by the yeast AP-1 protein is required for normal cadmium tolerance.
Harshman, KD; Moye-Rowley, WS; Parker, CS; Wemmie, JA; Wu, AL, 1994)		0.48
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
herbicideA substance used to destroy plant pests.
EC 2.2.1.6 (acetolactate synthase) inhibitorAn EC 2.2.1.* (transketolase/transaldolase) inhibitor that interferes with the action of acetolactate synthase (EC 2.2.1.6).
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (3)

ClassDescription
pyrimidinesAny compound having a pyrimidine as part of its structure.
benzoate esterEsters of benzoic acid or substituted benzoic acids.
N-sulfonylureaA urea in which one of the hydrogens attached to a nitrogen of the urea group is replaced by a sulfonyl group. The N-sulfonylurea moiety is a key group in various herbicides, as well as in a number of antidiabetic drugs used in the management of type 2 diabetis mellitus.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (2)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
acetylcholinesteraseHomo sapiens (human)Potency3.17060.002541.796015,848.9004AID1347395
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Acetolactate synthase catalytic subunit, mitochondrialSaccharomyces cerevisiae S288CKi0.05080.00330.12840.4000AID721536
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (37)

Assay IDTitleYearJournalArticle
AID370056Antimycobacterial activity against Mycobacterium tuberculosis2005Antimicrobial agents and chemotherapy, Jun, Volume: 49, Issue:6
New small-molecule synthetic antimycobacterials.
AID1205463Antitubercular activity against rifampin, isoniazid, amikacin and ofloxacin-resistant Mycobacterium tuberculosis assessed as inhibition of bacterial growth after 4 weeks by two-fold dilution technique2015European journal of medicinal chemistry, Apr-13, Volume: 94Synthesis, crystal structure and biological evaluation of substituted quinazolinone benzoates as novel antituberculosis agents targeting acetohydroxyacid synthase.
AID1205464Antitubercular activity against rifampin, isoniazid, kanamycin and ofloxacin-resistant Mycobacterium tuberculosis assessed as inhibition of bacterial growth after 4 weeks by two-fold dilution technique2015European journal of medicinal chemistry, Apr-13, Volume: 94Synthesis, crystal structure and biological evaluation of substituted quinazolinone benzoates as novel antituberculosis agents targeting acetohydroxyacid synthase.
AID1205471Antitubercular activity against rifampin, isoniazid and ethambutol-resistant Mycobacterium tuberculosis infected in human THP-1 cells assessed as inhibition of intracellular activity at 20 mg/L after 4 days2015European journal of medicinal chemistry, Apr-13, Volume: 94Synthesis, crystal structure and biological evaluation of substituted quinazolinone benzoates as novel antituberculosis agents targeting acetohydroxyacid synthase.
AID1205468Antitubercular activity against isoniazid-resistant Mycobacterium tuberculosis infected in human THP-1 cells assessed as inhibition of intracellular activity at 20 mg/L after 4 days2015European journal of medicinal chemistry, Apr-13, Volume: 94Synthesis, crystal structure and biological evaluation of substituted quinazolinone benzoates as novel antituberculosis agents targeting acetohydroxyacid synthase.
AID1205459Antitubercular activity against isoniazid-resistant Mycobacterium tuberculosis assessed as inhibition of bacterial growth after 4 weeks by two-fold dilution technique2015European journal of medicinal chemistry, Apr-13, Volume: 94Synthesis, crystal structure and biological evaluation of substituted quinazolinone benzoates as novel antituberculosis agents targeting acetohydroxyacid synthase.
AID721538Antifungal activity against Candida albicans after 72 hrs by broth microdilution method2013Journal of medicinal chemistry, Jan-10, Volume: 56, Issue:1
Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthase.
AID1205466Antitubercular activity against Mycobacterium tuberculosis H37Rv ATCC 27294 infected in human THP-1 cells assessed as inhibition of intracellular activity at 20 mg/L after 4 days2015European journal of medicinal chemistry, Apr-13, Volume: 94Synthesis, crystal structure and biological evaluation of substituted quinazolinone benzoates as novel antituberculosis agents targeting acetohydroxyacid synthase.
AID1205479Antitubercular activity against rifampin, isoniazid and ethambutol-resistant Mycobacterium tuberculosis infected in human THP-1 cells assessed as inhibition of intracellular activity at 10 mg/L after 4 days2015European journal of medicinal chemistry, Apr-13, Volume: 94Synthesis, crystal structure and biological evaluation of substituted quinazolinone benzoates as novel antituberculosis agents targeting acetohydroxyacid synthase.
AID1205461Antitubercular activity against rifampin, isoniazid and streptomycin-resistant Mycobacterium tuberculosis assessed as inhibition of bacterial growth after 4 weeks by two-fold dilution technique2015European journal of medicinal chemistry, Apr-13, Volume: 94Synthesis, crystal structure and biological evaluation of substituted quinazolinone benzoates as novel antituberculosis agents targeting acetohydroxyacid synthase.
AID1205474Antitubercular activity against Mycobacterium tuberculosis H37Rv ATCC 27294 infected in human THP-1 cells assessed as inhibition of intracellular activity at 10 mg/L after 4 days2015European journal of medicinal chemistry, Apr-13, Volume: 94Synthesis, crystal structure and biological evaluation of substituted quinazolinone benzoates as novel antituberculosis agents targeting acetohydroxyacid synthase.
AID1205472Antitubercular activity against rifampin, isoniazid, amikacin and ofloxacin-resistant Mycobacterium tuberculosis infected in human THP-1 cells assessed as inhibition of intracellular activity at 20 mg/L after 4 days2015European journal of medicinal chemistry, Apr-13, Volume: 94Synthesis, crystal structure and biological evaluation of substituted quinazolinone benzoates as novel antituberculosis agents targeting acetohydroxyacid synthase.
AID1205478Antitubercular activity against rifampin, isoniazid and streptomycin-resistant Mycobacterium tuberculosis infected in human THP-1 cells assessed as inhibition of intracellular activity at 10 mg/L after 4 days2015European journal of medicinal chemistry, Apr-13, Volume: 94Synthesis, crystal structure and biological evaluation of substituted quinazolinone benzoates as novel antituberculosis agents targeting acetohydroxyacid synthase.
AID1205456Inhibition of Mycobacterium tuberculosis AHAS catalytic subunit assessed as inhibition of acetoin formation using acetolactate as substrate after 1 hr2015European journal of medicinal chemistry, Apr-13, Volume: 94Synthesis, crystal structure and biological evaluation of substituted quinazolinone benzoates as novel antituberculosis agents targeting acetohydroxyacid synthase.
AID1139715Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 7 days by resazurin assay2014Bioorganic & medicinal chemistry letters, May-01, Volume: 24, Issue:9
Design and synthesis of triazolopyrimidine acylsulfonamides as novel anti-mycobacterial leads acting through inhibition of acetohydroxyacid synthase.
AID647601Antituberculosis activity against Mycobacterium tuberculosis H37Rv ATCC 272942012European journal of medicinal chemistry, Apr, Volume: 50Synthesis and evaluation of novel monosubstituted sulfonylurea derivatives as antituberculosis agents.
AID721536Inhibition of Saccharomyces cerevisiae acetohydroxyacid synthase by colorimetric assay2013Journal of medicinal chemistry, Jan-10, Volume: 56, Issue:1
Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthase.
AID721543Antifungal activity against Cryptococcus neoformans expressing Saccharomyces cerevisiae AHAS gene after 48 hrs by broth microdilution assay2013Journal of medicinal chemistry, Jan-10, Volume: 56, Issue:1
Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthase.
AID1205457Antitubercular activity against Mycobacterium tuberculosis H37Rv ATCC 27294 assessed as inhibition of bacterial growth after 4 weeks by two-fold dilution technique2015European journal of medicinal chemistry, Apr-13, Volume: 94Synthesis, crystal structure and biological evaluation of substituted quinazolinone benzoates as novel antituberculosis agents targeting acetohydroxyacid synthase.
AID1205470Antitubercular activity against rifampin, isoniazid and streptomycin-resistant Mycobacterium tuberculosis infected in human THP-1 cells assessed as inhibition of intracellular activity at 20 mg/L after 4 days2015European journal of medicinal chemistry, Apr-13, Volume: 94Synthesis, crystal structure and biological evaluation of substituted quinazolinone benzoates as novel antituberculosis agents targeting acetohydroxyacid synthase.
AID1090270Resistance factor, ratio of Kiapp for Arabidopsis thaliana AHAS A122V mutant to Kiapp for wild type Arabidopsis thaliana AHAS2006Proceedings of the National Academy of Sciences of the United States of America, Jan-17, Volume: 103, Issue:3
Herbicide-binding sites revealed in the structure of plant acetohydroxyacid synthase.
AID1205460Antitubercular activity against rifampin and isoniazid-resistant Mycobacterium tuberculosis assessed as inhibition of bacterial growth after 4 weeks by two-fold dilution technique2015European journal of medicinal chemistry, Apr-13, Volume: 94Synthesis, crystal structure and biological evaluation of substituted quinazolinone benzoates as novel antituberculosis agents targeting acetohydroxyacid synthase.
AID721539Antifungal activity against Saccharomyces cerevisiae after 72 hrs by broth microdilution assay2013Journal of medicinal chemistry, Jan-10, Volume: 56, Issue:1
Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthase.
AID1139717Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 7 days by resazurin assay in presence of Isoleucine, Leucine and Valine2014Bioorganic & medicinal chemistry letters, May-01, Volume: 24, Issue:9
Design and synthesis of triazolopyrimidine acylsulfonamides as novel anti-mycobacterial leads acting through inhibition of acetohydroxyacid synthase.
AID1205477Antitubercular activity against rifampin and isoniazid-resistant Mycobacterium tuberculosis infected in human THP-1 cells assessed as inhibition of intracellular activity at 10 mg/L after 4 days2015European journal of medicinal chemistry, Apr-13, Volume: 94Synthesis, crystal structure and biological evaluation of substituted quinazolinone benzoates as novel antituberculosis agents targeting acetohydroxyacid synthase.
AID1205462Antitubercular activity against rifampin, isoniazid and ethambutol-resistant Mycobacterium tuberculosis assessed as inhibition of bacterial growth after 4 weeks by two-fold dilution technique2015European journal of medicinal chemistry, Apr-13, Volume: 94Synthesis, crystal structure and biological evaluation of substituted quinazolinone benzoates as novel antituberculosis agents targeting acetohydroxyacid synthase.
AID1205475Antitubercular activity against isoniazid, rifampin, streptomycin, ethambutol, amikacin, ofloxacin, kanamycin-susceptible Mycobacterium tuberculosis infected in human THP-1 cells assessed as inhibition of intracellular activity at 10 mg/L after 4 days2015European journal of medicinal chemistry, Apr-13, Volume: 94Synthesis, crystal structure and biological evaluation of substituted quinazolinone benzoates as novel antituberculosis agents targeting acetohydroxyacid synthase.
AID1205469Antitubercular activity against rifampin and isoniazid-resistant Mycobacterium tuberculosis infected in human THP-1 cells assessed as inhibition of intracellular activity at 20 mg/L after 4 days2015European journal of medicinal chemistry, Apr-13, Volume: 94Synthesis, crystal structure and biological evaluation of substituted quinazolinone benzoates as novel antituberculosis agents targeting acetohydroxyacid synthase.
AID1090269Resistance factor, ratio of Ki for Saccharomyces cerevisiae AHAS A117V mutant to Ki for wild type Saccharomyces cerevisiae AHAS2006Proceedings of the National Academy of Sciences of the United States of America, Jan-17, Volume: 103, Issue:3
Herbicide-binding sites revealed in the structure of plant acetohydroxyacid synthase.
AID1205473Antitubercular activity against rifampin, isoniazid, kanamycin and ofloxacin-resistant Mycobacterium tuberculosis infected in human THP-1 cells assessed as inhibition of intracellular activity at 20 mg/L after 4 days2015European journal of medicinal chemistry, Apr-13, Volume: 94Synthesis, crystal structure and biological evaluation of substituted quinazolinone benzoates as novel antituberculosis agents targeting acetohydroxyacid synthase.
AID721535Inhibition of Candida albicans acetohydroxyacid synthase catalytic domain expressed in Escherichia coli by colorimetric method2013Journal of medicinal chemistry, Jan-10, Volume: 56, Issue:1
Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthase.
AID1205481Antitubercular activity against rifampin, isoniazid, kanamycin and ofloxacin-resistant Mycobacterium tuberculosis infected in human THP-1 cells assessed as inhibition of intracellular activity at 10 mg/L after 4 days2015European journal of medicinal chemistry, Apr-13, Volume: 94Synthesis, crystal structure and biological evaluation of substituted quinazolinone benzoates as novel antituberculosis agents targeting acetohydroxyacid synthase.
AID1205476Antitubercular activity against isoniazid-resistant Mycobacterium tuberculosis infected in human THP-1 cells assessed as inhibition of intracellular activity at 10 mg/L after 4 days2015European journal of medicinal chemistry, Apr-13, Volume: 94Synthesis, crystal structure and biological evaluation of substituted quinazolinone benzoates as novel antituberculosis agents targeting acetohydroxyacid synthase.
AID1205467Antitubercular activity against isoniazid, rifampin, streptomycin, ethambutol, amikacin, ofloxacin, kanamycin-susceptible Mycobacterium tuberculosis infected in human THP-1 cells assessed as inhibition of intracellular activity at 20 mg/L after 4 days2015European journal of medicinal chemistry, Apr-13, Volume: 94Synthesis, crystal structure and biological evaluation of substituted quinazolinone benzoates as novel antituberculosis agents targeting acetohydroxyacid synthase.
AID1205458Antitubercular activity against isoniazid, rifampin, streptomycin, ethambutol, amikacin, ofloxacin, kanamycin-susceptible Mycobacterium tuberculosis assessed as inhibition of bacterial growth after 4 weeks by two-fold dilution technique2015European journal of medicinal chemistry, Apr-13, Volume: 94Synthesis, crystal structure and biological evaluation of substituted quinazolinone benzoates as novel antituberculosis agents targeting acetohydroxyacid synthase.
AID1139716Inhibition of Mycobacterium tuberculosis acetohydroxy acid synthase after 60 mins by acetoin formation-based colorimetry2014Bioorganic & medicinal chemistry letters, May-01, Volume: 24, Issue:9
Design and synthesis of triazolopyrimidine acylsulfonamides as novel anti-mycobacterial leads acting through inhibition of acetohydroxyacid synthase.
AID1205480Antitubercular activity against rifampin, isoniazid, amikacin and ofloxacin-resistant Mycobacterium tuberculosis infected in human THP-1 cells assessed as inhibition of intracellular activity at 10 mg/L after 4 days2015European journal of medicinal chemistry, Apr-13, Volume: 94Synthesis, crystal structure and biological evaluation of substituted quinazolinone benzoates as novel antituberculosis agents targeting acetohydroxyacid synthase.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (56)

TimeframeStudies, This Drug (%)All Drugs %
pre-199013 (23.21)18.7374
1990's9 (16.07)18.2507
2000's16 (28.57)29.6817
2010's10 (17.86)24.3611
2020's8 (14.29)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 25.07

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index25.07 (24.57)
Research Supply Index4.08 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index51.19 (26.88)
Search Engine Supply Index3.93 (0.95)

This Compound (25.07)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (1.72%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other57 (98.28%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
alpha-aceto-alpha-hydroxybutyrate
alpha-aceto-alpha-hydroxybutyrate: RN given refers to cpd without isomeric designation		1.9910hydroxy fatty acid
alpha-ketobutyric acid
alpha-ketobutyric acid: RN given refers to parent cpd; structure. 2-oxobutanoic acid : A 2-oxo monocarboxylic acid that is the 2-oxo derivative of butanoic acid.		3.23602-oxo monocarboxylic acid;
short-chain fatty acid
glycine
[no description available]		2.0610alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid		EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical
methanol
Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.. primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.. methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.		6.9910alkyl alcohol;
one-carbon compound;
primary alcohol;
volatile organic compound		amphiprotic solvent;
Escherichia coli metabolite;
fuel;
human metabolite;
mouse metabolite;
Mycoplasma genitalium metabolite
niacin
Niacin: A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.. vitamin B3 : Any member of a group of vitamers that belong to the chemical structural class called pyridines that exhibit biological activity against vitamin B3 deficiency. Vitamin B3 deficiency causes a condition known as pellagra whose symptoms include depression, dermatitis and diarrhea. The vitamers include nicotinic acid and nicotinamide (and their ionized and salt forms).. nicotinic acid : A pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group.		2.0110pyridine alkaloid;
pyridinemonocarboxylic acid;
vitamin B3		antidote;
antilipemic drug;
EC 3.5.1.19 (nicotinamidase) inhibitor;
Escherichia coli metabolite;
human urinary metabolite;
metabolite;
mouse metabolite;
plant metabolite;
vasodilator agent
picolinic acid
picolinic acid: iron-chelating agent that inhibits DNA synthesis; may interfere with iron-dependent production of stable free organic radical which is essential for ribonucleotide reductase formation of deoxyribonucleotides; RN given refers to parent cpd; structure in Merck Index, 9th ed, #7206. picolinic acid : A pyridinemonocarboxylic acid in which the carboxy group is located at position 2. It is an intermediate in the metabolism of tryptophan.		2.110pyridinemonocarboxylic acidhuman metabolite;
MALDI matrix material
thiamine
thiamine(1+) : A primary alcohol that is 1,3-thiazol-3-ium substituted by (4-amino-2-methylpyrimidin-5-yl)methyl, methyl and 2-hydroxyethyl groups at positions 3, 4 and 5, respectively.		1.9710primary alcohol;
vitamin B1		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
2,4-dichlorophenoxyacetic acid
2,4-Dichlorophenoxyacetic Acid: An herbicide with irritant effects on the eye and the gastrointestinal system.. 2,4-D : A chlorophenoxyacetic acid that is phenoxyacetic acid in which the ring hydrogens at postions 2 and 4 are substituted by chlorines.		2.110chlorophenoxyacetic acid;
dichlorobenzene		agrochemical;
defoliant;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
environmental contaminant;
phenoxy herbicide;
synthetic auxin
clotrimazole
[no description available]		2.0210conazole antifungal drug;
imidazole antifungal drug;
imidazoles;
monochlorobenzenes		antiinfective agent;
environmental contaminant;
xenobiotic
diuron
Diuron: A pre-emergent herbicide.. diuron : A member of the class of 3-(3,4-substituted-phenyl)-1,1-dimethylureas that is urea in which both of the hydrogens attached to one nitrogen are substituted by methyl groups, and one of the hydrogens attached to the other nitrogen is substituted by a 3,4-dichlorophenyl group.		3.11403-(3,4-substituted-phenyl)-1,1-dimethylurea;
dichlorobenzene		environmental contaminant;
mitochondrial respiratory-chain inhibitor;
photosystem-II inhibitor;
urea herbicide;
xenobiotic
endosulfan
Endosulfan: A polychlorinated compound used for controlling a variety of insects. It is practically water-insoluble, but readily adheres to clay particles and persists in soil and water for several years. Its mode of action involves repetitive nerve-discharges positively correlated to increase in temperature. This compound is extremely toxic to most fish. (From Comp Biochem Physiol (C) 1993 Jul;105(3):347-61). endosulfan : A cyclic sulfite ester that is 1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepine 3-oxide substituted by chloro groups at positions 6, 7, 8, 9, 10 and 10.		1.9710cyclic sulfite ester;
cyclodiene organochlorine insecticide		acaricide;
agrochemical;
GABA-gated chloride channel antagonist;
persistent organic pollutant
fluconazole
Fluconazole: Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.. fluconazole : A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.		2.4220conazole antifungal drug;
difluorobenzene;
tertiary alcohol;
triazole antifungal drug		environmental contaminant;
P450 inhibitor;
xenobiotic
isoniazid
Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.. hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).		2.1110carbohydrazideantitubercular agent;
drug allergen
malathion
Malathion: A wide spectrum aliphatic organophosphate insecticide widely used for both domestic and commercial agricultural purposes.. malathion : A racemate comprising equimolar amounts of (R) and (S)-malathion. It is a broad spectrum organophosphate proinsecticide used to control a wide range of pests including Coleoptera, Diptera, fruit flies, mosquitos and spider mites.. diethyl 2-[(dimethoxyphosphorothioyl)thio]succinate : A diester that is diethyl succinate in which position 2 is substituted by a (dimethoxyphosphorothioyl)thio group.		1.9710diester;
ethyl ester;
organic thiophosphate
alanine
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.. alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.		2.3110alanine zwitterion;
alanine;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid		EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor;
fundamental metabolite
chloramphenicol
Amphenicol: Chloramphenicol and its derivatives.		1.9610C-nitro compound;
carboxamide;
diol;
organochlorine compound		antibacterial drug;
antimicrobial agent;
Escherichia coli metabolite;
geroprotector;
Mycoplasma genitalium metabolite;
protein synthesis inhibitor
aspartic acid
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.. aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent. L-aspartic acid : The L-enantiomer of aspartic acid.		2.3110aspartate family amino acid;
aspartic acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
mouse metabolite;
neurotransmitter
methionine
Methionine: A sulfur-containing essential L-amino acid that is important in many body functions.. methionine : A sulfur-containing amino acid that is butyric acid bearing an amino substituent at position 2 and a methylthio substituent at position 4.		1.9710aspartate family amino acid;
L-alpha-amino acid;
methionine zwitterion;
methionine;
proteinogenic amino acid		antidote to paracetamol poisoning;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical
cycloheximide
Cycloheximide: Antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation during protein synthesis.. cycloheximide : A dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus.		2.940antibiotic fungicide;
cyclic ketone;
dicarboximide;
piperidine antibiotic;
piperidones;
secondary alcohol		anticoronaviral agent;
bacterial metabolite;
ferroptosis inhibitor;
neuroprotective agent;
protein synthesis inhibitor
valine
Valine: A branched-chain essential amino acid that has stimulant activity. It promotes muscle growth and tissue repair. It is a precursor in the penicillin biosynthetic pathway.. valine : A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isopropyl group.. L-valine : The L-enantiomer of valine.		8.0850L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid;
valine		algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
isoleucine
Isoleucine: An essential branched-chain aliphatic amino acid found in many proteins. It is an isomer of LEUCINE. It is important in hemoglobin synthesis and regulation of blood sugar and energy levels.. isoleucine : A 2-amino-3-methylpentanoic acid having either (2R,3R)- or (2S,3S)-configuration.. L-isoleucine : The L-enantiomer of isoleucine.		8.0950aspartate family amino acid;
isoleucine;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
pantothenic acid
Pantothenic Acid: A butyryl-beta-alanine that can also be viewed as pantoic acid complexed with BETA ALANINE. It is incorporated into COENZYME A and protects cells against peroxidative damage by increasing the level of GLUTATHIONE.. pantothenic acid : A member of the class of pantothenic acids that is an amide formed from pantoic acid and beta-alanine.. vitamin B5 : Any member of a group of vitamers that belong to the chemical structural class called pantothenic acids that exhibit biological activity against vitamin B5 deficiency. Deficiency of vitamin B5 is rare due to its widespread distribution in whole grain cereals, legumes and meat. Symptoms associated with vitamin B5 deficiency are difficult to asses since they are subtle and resemble those of other B vitamin deficiencies. The vitamers include (R)-pantothenic acid and its ionized and salt forms.. (R)-pantothenate : A pantothenate that is the conjugate base of (R)-pantothenic acid, obtained by deprotonation of the carboxy group.. (R)-pantothenic acid : A pantothenic acid having R-configuration.		1.9710pantothenic acid;
vitamin B5		antidote to curare poisoning;
geroprotector;
human blood serum metabolite
diquat
Diquat: A contact herbicide used also to produce desiccation and defoliation. (From Merck Index, 11th ed). diquat : The organic cation formed formally by addition of an ethylene bridge between the nitrogen atoms of 2,2'-bipyridine. Most often available as the dibromide.		1.9710organic cationdefoliant;
herbicide
thiophenes
Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.		2.0510mancude organic heteromonocyclic parent;
monocyclic heteroarene;
thiophenes;
volatile organic compound		non-polar solvent
thiamine pyrophosphate
Thiamine Pyrophosphate: The coenzyme form of Vitamin B1 present in many animal tissues. It is a required intermediate in the PYRUVATE DEHYDROGENASE COMPLEX and the KETOGLUTARATE DEHYDROGENASE COMPLEX.. thiamine(1+) diphosphate chloride : An organic chloride salt of thiamine(1+) diphosphate.		2.0210organic chloride salt;
vitamin B1
decyltrimethylammonium
decyltrimethylammonium ion : A quarternary ammonium cation having one decyl and three methyl substituents around the central nitrogen.		2.0110quaternary ammonium ion
cadmium
Cadmium: An element with atomic symbol Cd, atomic number 48, and atomic weight 112.41. It is a metal and ingestion will lead to CADMIUM POISONING.. elemental cadmium : An element in the zinc group of the periodic table with atomic number 48, atomic mass 112, M.P. 321degreeC, and B.P. 765degreeC). An odourless, tasteless, and highly poisonous soft, ductile, lustrous metal with electropositive properties. It has eight stable isotopes: (106)Cd, (108)Cd,(110)Cd, (111)Cd, (112)Cd, (113)Cd, (114)Cd and (116)Cd, with (112)Cd and (114)Cd being the most common.		1.9810cadmium molecular entity;
zinc group element atom
hexazinone
hexazinone: RN given refers to parent cpd; structure in first source		3.11401,3,5-triazines
permethrin
hemoglobin Atlanta-Coventry: Leu replaced by Pro at beta75 and Leu deleted at beta141		1.9710cyclopropanecarboxylate ester;
cyclopropanes		agrochemical;
ectoparasiticide;
pyrethroid ester acaricide;
pyrethroid ester insecticide;
scabicide
chlorsulfuron
chlorsulfuron: RN given refers to parent cpd; structure given in first source. chlorsulfuron : An N-sulfonylurea that is N-carbamoyl-2-chlorobenzenesulfonamide in which one of the hydrogens attached to the non-sulfonylated nitrogen has been replaced by a 4-methoxy-6-methyl-1,3,5-triazin-2-yl group. A herbicide used for the control of broadleaf weeds in wheat, barley and oats.		2.4520methoxy-1,3,5-triazine;
monochlorobenzenes;
N-sulfonylurea		agrochemical;
EC 2.2.1.6 (acetolactate synthase) inhibitor;
herbicide
metsulfuron methyl
metsulfuron methyl : A N-sulfonylurea in which the sulfonyl group is attached to a 2-(methoxycarbonyl)phenyl group while a (4-methoxy-6-methyl-1,3,5-triazin-2-yl group replaces one of the amino hydrogens of the remaining urea group.		2.02101,3,5-triazines;
benzoate ester;
N-sulfonylurea		environmental contaminant;
herbicide;
xenobiotic
imazapyr, (+-)-isomer
imazapyr: RN given refers to parent cpd without isomeric designation. imazapyr : A racemate comprising equimolar amounts of (R)- and (S)-imazapyr. An inhibitor of acetohydroxyacid synthase, it is used (generally as the isopropylamine salt, known as imazapyr-isopropylammonium) as a herbicide, particularly for the control of perennial grasses, broad-leaved weeds, woody plants, brambles, etc., on non-crop land. It is not approved for use within the European Union.. 2-(4-isopropyl-4-methyl-5-oxo-4,5-dihydro-1H-imidazol-2-yl)nicotinic acid : A pyridinemonocarboxylic acid that is nicotinic acid which is substituted at position 2 by a 4,5-dihydro-imidazol-2-yl group, which in turn is substituted at positions 4, 4, and 5 by isopropyl, ethyl, and oxo groups, respectively.		2.0110imidazolines;
imidazolone;
pyridinemonocarboxylic acid;
pyridines
methyl bensulfuron
methyl bensulfuron: RN given refers to parent cpds. bensulfuron-methyl : The methyl ester of bensulfuron. An acetolactate synthase inhibitor, it is used as a herbicide for the control of a variety of both annual and perennial weeds in crops, particularly wheat and rice. It is not licensed for use within the UK.		2.4320aromatic ether;
methyl ester;
N-sulfonylurea;
pyrimidines		agrochemical;
EC 2.2.1.6 (acetolactate synthase) inhibitor;
herbicide
chlorimuron ethyl
chlorimuron ethyl: structure in first source. chlorimuron-ethyl : An ethyl ester resulting from the formal condensation of the carboxy group of chlorimuron with ethanol. A proherbicide for chloimuron, it is used as herbicide for the control of broad-leaved weeds in peanuts, soya beans, and other crops.		2.7330aromatic ether;
ethyl ester;
N-sulfonylurea;
organochlorine pesticide;
pyrimidines;
sulfamoylbenzoate		agrochemical;
EC 2.2.1.6 (acetolactate synthase) inhibitor;
proherbicide
triazoles
Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.		2.25101,2,3-triazole
nicosulfuron
nicosulfuron: inhibits ACETOLACTATE SYNTHASE; Accent is DuPont brand name. nicosulfuron : A N-sulfonylurea that is 2-(carbamoylsulfamoyl)-N,N-dimethylpyridine-3-carboxamide substituted by a 4,6-dimethoxypyrimidin-2-yl group at the amino nitrogen.		2.0510N-sulfonylurea;
pyridines;
pyrimidines		environmental contaminant;
herbicide;
xenobiotic
thifensulfuron methyl
thifensulfuron methyl: structure in first source. thifensulfuron-methyl : A methyl ester resulting from the formal condensation of the carboxy group of thifensulfuron with methanol. It is used as a post-emergence herbicide for the control of grass and broad-leaved weeds.		2.05101,3,5-triazines;
methyl ester;
N-sulfonylurea;
thiophenes		agrochemical;
environmental contaminant;
herbicide;
xenobiotic
alpha-acetolactate
alpha-acetolactate: RN given refers to cpd without isomeric designation		1.9910
ethyl 5-(4,6-dimethoxypyrimidin-2-ylcarbamoylsulfamoyl)-1-methylpyrazole-4-carboxylate
ethyl 5-(4,6-dimethoxypyrimidin-2-ylcarbamoylsulfamoyl)-1-methylpyrazole-4-carboxylate: structure in first source		2.0810pyrazoles
methyl 2-(((((4-ethoxy-6-(methylamino)-1,3,5-triazin-2-yl)amino)carbonyl)amino)sulfonyl)benzoate
ethametsulfuron-methyl : A methyl ester resulting from the formal condensation of the carboxy group of ethametsulfuron with methanol. A herbicide used for the control of broad-leaved weeds in oil seed rape and fodder rape.		2.0810aromatic ether;
benzoate ester;
diamino-1,3,5-triazine;
methyl ester;
N-sulfonylurea		EC 2.2.1.6 (acetolactate synthase) inhibitor;
herbicide
metsulfuron methyl
tribenuron methyl : The methyl ester of tribenuron.		2.4620methoxy-1,3,5-triazine;
methyl ester;
N-sulfonylurea		herbicide
ergosterol
[no description available]		2103beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
ergostanoid;
phytosterols		fungal metabolite;
Saccharomyces cerevisiae metabolite
pa 824
pretomanid: nitroimidazopyran derived from 5-nitroimidazoles; a prodrug that requires activation by a bacterial F420-depedent glucose-6-phosphate dehydrogenase (Fgd) and nitroreductase to activate components that then inhibit bacterial mycolic acid and protein synthesis; structure in first source		3.1210
bm 212
BM 212: anti-mycobacterial agent; structure in first source		3.1210
u 100480
U 100480: structure given in first source		3.1210
flavin-adenine dinucleotide
Flavin-Adenine Dinucleotide: A condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)		2.0210flavin adenine dinucleotide;
vitamin B2		cofactor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
prosthetic group
1-(4,6-dimethoxypyrimidin-2-yl)-3-(2-ethoxyphenoxysulfonyl)urea
1-(4,6-dimethoxypyrimidin-2-yl)-3-(2-ethoxyphenoxysulfonyl)urea: herbicide; structure in first source		2.0810aromatic ether
bedaquiline
bedaquiline: a diarylquinoline Antitubercular Agent. bedaquiline : A quinoline-based antimycobacterial drug used (as its fumarate salt) for the treatment of pulmonary multi-drug resistant tuberculosis by inhibition of ATP synthase, an enzyme essential for the replication of the mycobacteria.		3.1210aromatic ether;
naphthalenes;
organobromine compound;
quinolines;
tertiary alcohol;
tertiary amino compound		antitubercular agent;
ATP synthase inhibitor
n-hydroxy-n-isopropyloxamate
N-hydroxy-N-isopropyloxamate: inhibitor of ketol-acid reductoisomerase; structure given in first source; RN given refers to monopotassium salt		1.9910
salicylates
Salicylates: The salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.. hydroxybenzoate : Any benzoate derivative carrying a single carboxylate group and at least one hydroxy substituent.. salicylates : Any salt or ester arising from reaction of the carboxy group of salicylic acid, or any ester resulting from the condensation of the phenolic hydroxy group of salicylic acid with an organic acid.. salicylate : A monohydroxybenzoate that is the conjugate base of salicylic acid.		1.9910monohydroxybenzoateplant metabolite
pyrethrins
[no description available]		1.9710
oligomycins
Oligomycins: A closely related group of toxic substances elaborated by various strains of Streptomyces. They are 26-membered macrolides with lactone moieties and double bonds and inhibit various ATPases, causing uncoupling of phosphorylation from mitochondrial respiration. Used as tools in cytochemistry. Some specific oligomycins are RUTAMYCIN, peliomycin, and botrycidin (formerly venturicidin X).		1.9910
rifampin
Rifampin: A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)		2.1110cyclic ketal;
hydrazone;
N-iminopiperazine;
N-methylpiperazine;
rifamycins;
semisynthetic derivative;
zwitterion		angiogenesis inhibitor;
antiamoebic agent;
antineoplastic agent;
antitubercular agent;
DNA synthesis inhibitor;
EC 2.7.7.6 (RNA polymerase) inhibitor;
Escherichia coli metabolite;
geroprotector;
leprostatic drug;
neuroprotective agent;
pregnane X receptor agonist;
protein synthesis inhibitor
ConditionIndicatedRelationship StrengthStudiesTrials
Koch's Disease
[description not available]		02.4920
Tuberculosis
Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM TUBERCULOSIS.		02.4920
C gattii Infection
[description not available]		02.0210
Cryptococcosis
Fungal infection caused by genus CRYPTOCOCCUS.		02.0210