Compounds > essramycin
Page last updated: 2024-11-13

essramycin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

essramycin: from the culture broth of the marine Streptomyces; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID24829329
CHEMBL ID1642210
CHEBI ID70592
SCHEMBL ID17481557
MeSH IDM0525951

Synonyms (9)

Synonym
chebi:70592 ,
essramycin
CHEMBL1642210
1032394-06-1
SCHEMBL17481557
Q27138924
5-methyl-2-(2-oxo-2-phenylethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7(4h)-one
STARBLD0043329
5-methyl-2-phenacyl-1h-[1,2,4]triazolo[1,5-a]pyrimidin-7-one
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
triazolopyrimidines
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (29)

Assay IDTitleYearJournalArticle
AID550199Antibacterial activity against Escherichia coli ATCC 25922 compound formulated with carboxymethylcellulose2010Journal of natural products, Nov-29, Volume: 73, Issue:11
Synthesis of essramycin and comparison of its antibacterial activity.
AID550200Antibacterial activity against Pseudomonas aeruginosa ATCC 10145 compound formulated with carboxymethylcellulose2010Journal of natural products, Nov-29, Volume: 73, Issue:11
Synthesis of essramycin and comparison of its antibacterial activity.
AID550186Antibacterial activity against methicillin-susceptible Staphylococcus aureus ATCC 25923 up to 64 ug/ml after 24 hrs by broth dilution assay2010Journal of natural products, Nov-29, Volume: 73, Issue:11
Synthesis of essramycin and comparison of its antibacterial activity.
AID1419728Antibacterial activity against Bacillus subtilis ATCC 6051 after 24 hrs by serial dilution method2017Journal of natural products, 11-22, Volume: 80, Issue:11
Natural Products with Heteroatom-Rich Ring Systems.
AID1419736Antibacterial activity against Micrococcus luteus ATCC 9341 after 24 hrs by serial dilution method2017Journal of natural products, 11-22, Volume: 80, Issue:11
Natural Products with Heteroatom-Rich Ring Systems.
AID550187Antibacterial activity against Enterococcus faecalis VanB ATCC 51299 up to 64 ug/ml after 24 hrs by broth dilution assay2010Journal of natural products, Nov-29, Volume: 73, Issue:11
Synthesis of essramycin and comparison of its antibacterial activity.
AID550205Thermodynamic solubility in phosphate buffer at pH 7.4 after 72 hrs2010Journal of natural products, Nov-29, Volume: 73, Issue:11
Synthesis of essramycin and comparison of its antibacterial activity.
AID550190Antibacterial activity against Meropenem-resistant Pseudomonas aeruginosa up to 64 ug/ml after 24 hrs by broth dilution assay2010Journal of natural products, Nov-29, Volume: 73, Issue:11
Synthesis of essramycin and comparison of its antibacterial activity.
AID550203Cytotoxicity against HEK293 cells after 24 hrs by MTT assay2010Journal of natural products, Nov-29, Volume: 73, Issue:11
Synthesis of essramycin and comparison of its antibacterial activity.
AID1419735Antibacterial activity against Staphylococcus aureus ATCC 6538 after 24 hrs by serial dilution method2017Journal of natural products, 11-22, Volume: 80, Issue:11
Natural Products with Heteroatom-Rich Ring Systems.
AID1419737Antibacterial activity against Escherichia coli ATCC 10536 after 24 hrs by serial dilution method2017Journal of natural products, 11-22, Volume: 80, Issue:11
Natural Products with Heteroatom-Rich Ring Systems.
AID1635096Antibacterial activity against Acinetobacter baumannii ATCC 17961 up to 128 ug/ml after 16 to 20 hrs by broth microdilution assay2016Journal of natural products, Apr-22, Volume: 79, Issue:4
The Natural Product Essramycin and Three of Its Isomers Are Devoid of Antibacterial Activity.
AID550202Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay2010Journal of natural products, Nov-29, Volume: 73, Issue:11
Synthesis of essramycin and comparison of its antibacterial activity.
AID1635099Antibacterial activity against Escherichia coli ATCC 25922 up to 128 ug/ml after 16 to 20 hrs by broth microdilution assay2016Journal of natural products, Apr-22, Volume: 79, Issue:4
The Natural Product Essramycin and Three of Its Isomers Are Devoid of Antibacterial Activity.
AID1635098Antibacterial activity against Enterobacter aerogenes ATCC 35029 up to 128 ug/ml after 16 to 20 hrs by broth microdilution assay2016Journal of natural products, Apr-22, Volume: 79, Issue:4
The Natural Product Essramycin and Three of Its Isomers Are Devoid of Antibacterial Activity.
AID550201Antibacterial activity against Bacillus subtilis ATCC 6051 compound formulated with carboxymethylcellulose2010Journal of natural products, Nov-29, Volume: 73, Issue:11
Synthesis of essramycin and comparison of its antibacterial activity.
AID1635097Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 up to 128 ug/ml after 16 to 20 hrs by broth microdilution assay2016Journal of natural products, Apr-22, Volume: 79, Issue:4
The Natural Product Essramycin and Three of Its Isomers Are Devoid of Antibacterial Activity.
AID550188Antibacterial activity against Escherichia coli ATCC 25922 up to 64 ug/ml after 24 hrs by broth dilution assay2010Journal of natural products, Nov-29, Volume: 73, Issue:11
Synthesis of essramycin and comparison of its antibacterial activity.
AID1635095Antibacterial activity against Klebsiella pneumoniae ATCC 700603 up to 128 ug/ml after 16 to 20 hrs by broth microdilution assay2016Journal of natural products, Apr-22, Volume: 79, Issue:4
The Natural Product Essramycin and Three of Its Isomers Are Devoid of Antibacterial Activity.
AID550191Antibacterial activity against Meropenem-resistant Acinetobacter baumannii up to 64 ug/ml after 24 hrs by broth dilution assay2010Journal of natural products, Nov-29, Volume: 73, Issue:11
Synthesis of essramycin and comparison of its antibacterial activity.
AID550204Kinetic solubility in phosphate buffer at pH 7.42010Journal of natural products, Nov-29, Volume: 73, Issue:11
Synthesis of essramycin and comparison of its antibacterial activity.
AID1419738Antibacterial activity against Pseudomonas aeruginosa ATCC 10145 after 24 hrs by serial dilution method2017Journal of natural products, 11-22, Volume: 80, Issue:11
Natural Products with Heteroatom-Rich Ring Systems.
AID1635100Antibacterial activity against Enterococcus faecium ATCC 19734 up to 128 ug/ml after 16 to 20 hrs by broth microdilution assay2016Journal of natural products, Apr-22, Volume: 79, Issue:4
The Natural Product Essramycin and Three of Its Isomers Are Devoid of Antibacterial Activity.
AID550208Thermodynamic solubility in water after 72 hrs2010Journal of natural products, Nov-29, Volume: 73, Issue:11
Synthesis of essramycin and comparison of its antibacterial activity.
AID1635101Antibacterial activity against Staphylococcus aureus ATCC 29213 up to 128 ug/ml after 16 to 20 hrs by broth microdilution assay2016Journal of natural products, Apr-22, Volume: 79, Issue:4
The Natural Product Essramycin and Three of Its Isomers Are Devoid of Antibacterial Activity.
AID550198Antibacterial activity against methicillin-susceptible Staphylococcus aureus ATCC 25923 compound formulated with carboxymethylcellulose2010Journal of natural products, Nov-29, Volume: 73, Issue:11
Synthesis of essramycin and comparison of its antibacterial activity.
AID550207Kinetic solubility in water2010Journal of natural products, Nov-29, Volume: 73, Issue:11
Synthesis of essramycin and comparison of its antibacterial activity.
AID550206Protein binding in LB assay broth (above 30 kDa) by ultra filtration method2010Journal of natural products, Nov-29, Volume: 73, Issue:11
Synthesis of essramycin and comparison of its antibacterial activity.
AID550189Antibacterial activity against Klebsiella pneumoniae ATCC 700603 up to 64 ug/ml after 24 hrs by broth dilution assay2010Journal of natural products, Nov-29, Volume: 73, Issue:11
Synthesis of essramycin and comparison of its antibacterial activity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's4 (66.67)24.3611
2020's1 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 17.74

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index17.74 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (17.74)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (16.67%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (83.33%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
1,2,4-triazole
1,2,4-triazole: RN given refers to 1H-1,2,4-triazole		2.05101,2,4-triazole
azacitidine
Azacitidine: A pyrimidine analogue that inhibits DNA methyltransferase, impairing DNA methylation. It is also an antimetabolite of cytidine, incorporated primarily into RNA. Azacytidine has been used as an antineoplastic agent.. 5-azacytidine : An N-glycosyl-1,3,5-triazine that is 4-amino-1,3,5-triazin-2(1H)-one substituted by a beta-D-ribofuranosyl residue via an N-glycosidic linkage. An antineoplastic agent, it is used in the treatment of myeloid leukaemia.		3.2510N-glycosyl-1,3,5-triazine;
nucleoside analogue		antineoplastic agent
triazoles
Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.		3.18501,2,3-triazole
lenthionine
lenthionine: isolated from the Shiitake mushroom Lenthinus edodes		3.2510pentathiepane
eudistomin e
eudistomin E: structure known; isolated from the marine tunicate Eudistoma album		3.2510
phidianidine a
phidianidine A: antineoplastic from the marine opisthobranch mollusk Phidiana militaris; structure in first source		3.2510
phidianidine b
phidianidine B: antineoplastic from the marine opisthobranch mollusk Phidiana militaris; structure in first source		3.2510
pyrimidinones
Pyrimidinones: Heterocyclic compounds known as 2-pyrimidones (or 2-hydroxypyrimidines) and 4-pyrimidones (or 4-hydroxypyrimidines) with the general formula C4H4N2O.		3.1850
ConditionIndicatedRelationship StrengthStudiesTrials