Compounds > triazoles
Page last updated: 2024-08-24

triazoles and Brain Neoplasms

triazoles has been researched along with Brain Neoplasms in 48 studies

Research

Studies (48)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (4.17)18.2507
2000's5 (10.42)29.6817
2010's33 (68.75)24.3611
2020's8 (16.67)2.80

Authors

AuthorsStudies
Jiang, M; Kong, J; Zhai, F1
Karbe, AG; Kremenetskaia, I; Onken, JS; Prem, M; Scherschinski, L; Tinhofer, I; Vajkoczy, P1
Kuo, YC; Lee, YJ; Rajesh, R1
Bhanja, D; Connor, J; Mansouri, A; Neighbors, J; Zadeh, G1
Abdullah, KG; Agar, NYR; Asara, JM; Bird, CE; Bonal, DM; Buehler, J; Cahill, DP; Cameron, AB; Dang, T; DeBerardinis, RJ; Endress, JE; Evans, L; Gao, W; Gattie, LC; Gradl, S; Guo, L; Harris, IS; Huang, B; Janzer, A; Jeffers, M; Jennings, RB; Kaelin, WG; Khanal, J; Kornblum, HI; Lee, JH; Lee, S; Lehrman, MA; Levitt, MM; Ligon, KL; Lin, YF; Looper, RE; Losman, JA; Ly, P; Mak, TW; Martin-Sandoval, MS; Mathews, TP; McBrayer, SK; Nguyen, QD; Puliyappadamba, VT; Regan, MS; Richardson, TE; Savani, MR; Shi, DD; Signoretti, S; Stopka, SA; Sutter, A; Wang, AC; Xiao, Y; Xu, L; Xu, M; Zacharias, LG1
Chen, X; Guo, B; Li, Y; Liang, H; Wang, D; Wang, Q; Wen, N; Xu, L; Zhang, L; Zhang, S; Zheng, H1
Bengtsson, J; Bolin, S; Čančer, M; Drews, LF; Forsberg-Nilsson, K; Nelander, S; Rosén, G; Swartling, FJ; Uhrbom, L; Weishaupt, H; Westermark, B1
Funck-Brentano, E; Nilsson, JA; Nilsson, LM; Vizlin-Hodzic, D1
Ang, BT; Cheng, HS; Chong, YK; Law, CLD; Low, ZYJ; Marvalim, C; Tan, NS; Tang, C; Zhu, P1
Chen, YJ; Ding, JC; Hu, GS; Hu, YH; Liu, JY; Liu, W; Xia, L; Xia, NS; Zheng, ZZ1
Bai, Y; Chen, Y; Dong, X; Han, Y; Jiang, S; Luo, SX; Wu, B; Zhang, H; Zhang, Y; Zhao, G; Zhong, S1
Alsheikh, H; Bastola, S; Chen, Z; Chhipa, R; DasGupta, B; Furuta, T; Gibson, JT; Hambardzumyan, D; Kang, KD; Kim, SH; Komarova, S; Lee, LJ; Lu, S; Lu, X; Minata, M; Nabors, B; Nakada, M; Nakano, I; Newell, EW; Norian, LA; Sabit, H; Sadahiro, H; Shi, J; Simoni, Y; Wang, J; Yamaguchi, S; Yu, H; Zhang, S1
Balkanska-Sinclair, E; Floyd, SR; Hammond, PT; Hwang, MK; Lam, FC; Maffa, A; Morton, SW; Vu Han, TL; Wyckoff, J; Yaffe, MB1
Camphausen, K; O'Neill, JW; Rath, BH; Tofilon, PJ; Wahba, A1
Baratta, MG1
Allam, M; Babu, PP; Bhavani, AKD; Mudiraj, A; Ranjan, N; Thippana, M1
Bianchetti, E; Ishida, CT; Karpel-Massler, G; Shang, E; Shu, C; Siegelin, MD; Westhoff, MA; Zhang, Y1
Boeva, V; De Preter, K; De Vloed, F; De Wyn, J; Decaesteker, B; Deforce, D; Denecker, G; Depuydt, P; Dolman, EM; Dreidax, D; Durinck, K; Essing, AHW; Gartlgruber, M; Henssen, A; Herrmann, C; Kholosy, WM; Koopmans, B; Loontiens, S; Mestdagh, P; Molenaar, JJ; Nunes, C; Rombaut, D; Schleiermacher, G; Schulte, JH; Speleman, F; Van Loocke, W; van Nes, J; Van Neste, C; Van Nieuwerburgh, F; Vanhauwaert, S; Verboom, K; Versteeg, R; Westermann, F1
Aibe, N; Kagiya, T; Nakamura, S; Nishimura, T; Okabe, H; Yamazaki, H; Yoshida, K1
Aibe, N; Kagiya, T; Kimoto, T; Kodani, N; Koizumi, M; Nakamura, S; Nishimura, T; Sihomi, H; Tsubokura, T; Yamazaki, H; Yoshida, K1
Engelbach, JA; Garbow, JR; Huang, C; Mach, RH; McConathy, J; Piwnica-Worms, D; Rich, KM; Sai, KK; Yuan, L; Zhou, D1
Dave, N; Desai, PB; Gudelsky, GA1
Korytova, LI; Masliukova, EA; Meshechkin, AV; Sokurenko, VP; Zhabina, RM1
Guo, RT; Li, XL; Li, Y; Luan, JW; Nie, D; Wu, J; You, QS; Zhang, LP1
Ahn, Y; Jang, HJ; Kwon, D; Lee, S; Lee, SJ; Oh, S; Park, BG; Park, JH; Park, YS; Shin, WS1
Bradner, JE; Janardhanam, VA; Rajagopalan, V; Vaidyanathan, M1
Green, AL; Hsu, JH; Hubbell-Engler, B; Jones, K; Knoff, DS; Kung, AL; Ligon, KL; Maire, CL; McCauley, D; Perry, JA; Ramkissoon, LA; Ramkissoon, SH; Shacham, S1
An, Q; Birt, M; Hafizi, S; Pilkington, GJ; Vouri, M1
Barr, CL; Cavenee, WK; Cloughesy, TF; Furnari, FB; Gahman, TC; Hon, GC; Ikegami, S; Jenkins, D; Kuan, S; Lee, AY; Li, B; Liu, F; Lucey, G; Mischel, PS; Ren, B; Shiau, AK; Turner, KM; Villa, GR; Wei, B; Yang, H; Ye, Z; Yong, WH; Zanca, C; Zhang, W1
Baryawno, N; Calero, R; Darabi, A; Dyberg, C; Einvik, C; Johnsen, JI; Kogner, P; Kool, M; Milosevic, J; Sandén, E; Siesjö, P; Sveinbjörnsson, B; Wickström, M1
Creekmore, A; Crowder, R; Doyle, A; Ellis, MJ; Erlichman, C; Gao, F; Guo, Z; Hoog, J; Lockhart, AC; Ma, CX; Naughton, M; Pluard, T; Sanchez, C1
Amico, AL; Olopade, OI; Saha, P1
Ahmad, F; Dixit, D; Ghildiyal, R; Joshi, SD; Sen, E1
Boyd, AW; Cryan, SA; Day, BW; Heilinger, T; Kim, EL; Lode, HN; O'Connor, G; Pokorny, JL; Prehn, JH; Ramsey, JM; Sarkaria, JN; Stringer, BW; Tivnan, A1
Abreu, P; Cameron, DA; Campos, SM; Guastalla, JP; Subar, M; Winer, EP1
Abounader, R; Buchanan, S; diPierro, C; Guessous, F; Marcinkiewicz, L; Sarkaria, J; Schiff, D; Zhang, Y1
Arnould, L; Coudert, B; Favier, L; Fumoleau, P; Guiu, S1
Adams, SJ; Griffin, EA; Jones, LA; Lee, H; Mach, RH; McConathy, J; Shockley, SE; Zhou, D1
Fukuda, M; Kishi, Y; Nakaoku, T; Nakatani, K; Saiki, M; Satow, T1
Cho, EJ; Chueh, HW; Kim, JY; Koo, HH; Lee, SH; Sung, KW; Yoo, KH1
Salameire, D1
Hikino, H; Koike, M; Mukai, T; Murata, Y1
Bhatt, ML; Kirti, S; Kumar, S; Madhup, R; Srivastava, M; Srivastava, PK1
Alavi, JB; Carson, KA; Fisher, JD; Grossman, SA; Lush, R; Mikkelsen, T; Rosenfeld, S1
Endo, W; Fujie, Y; Fukunaga, H; Hojo, S; Maeura, Y; Okada, Y; Ota, H; Yoshioka, S1
Albasanz, JL; Castillo, CA; Fernández, M; Martín, M1
Diserbo, M; Fatome, M; Lalouette, F; Martin, C; Verdetti, J1
Jacobs, W; Kohn, EC; Mikkelsen, T; Nelson, K; Rosenblum, ML; Smith, R1

Reviews

1 review(s) available for triazoles and Brain Neoplasms

ArticleYear
[Management of metastatic HER2-positive breast cancer: present and future].
    Bulletin du cancer, 2010, Volume: 97, Issue:3

    Topics: Anastrozole; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Benzoquinones; Bevacizumab; Brain Neoplasms; Breast Neoplasms; Disease Progression; Female; Heart; Humans; Lactams, Macrocyclic; Lapatinib; Letrozole; Neoplasm Proteins; Nitriles; Quinazolines; Quinolines; Receptor, ErbB-2; Trastuzumab; Triazoles

2010

Trials

4 trial(s) available for triazoles and Brain Neoplasms

ArticleYear
A Phase I Study of the AKT Inhibitor MK-2206 in Combination with Hormonal Therapy in Postmenopausal Women with Estrogen Receptor-Positive Metastatic Breast Cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2016, 06-01, Volume: 22, Issue:11

    Topics: Adult; Aged; Anastrozole; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biomarkers, Tumor; Brain Neoplasms; Breast Neoplasms; Cell Line, Tumor; Drug Synergism; Estradiol; Female; Fulvestrant; Heterocyclic Compounds, 3-Ring; Humans; Hyperglycemia; Hypoglycemic Agents; Maximum Tolerated Dose; Middle Aged; Nitriles; Proto-Oncogene Proteins c-akt; Receptors, Estrogen; Treatment Outcome; Triazoles

2016
A comparative study of exemestane versus anastrozole in patients with postmenopausal breast cancer with visceral metastases.
    Clinical breast cancer, 2009, Volume: 9, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Anastrozole; Androstadienes; Aromatase Inhibitors; Brain Neoplasms; Breast Neoplasms; Female; Humans; Liver Neoplasms; Lung Neoplasms; Middle Aged; Nitriles; Pilot Projects; Postmenopause; Prognosis; Retrospective Studies; Survival Rate; Treatment Outcome; Triazoles

2009
Iron chelation treatment with deferasirox prior to high-dose chemotherapy and autologous stem cell transplantation may reduce the risk of hepatic veno-occlusive disease in children with high-risk solid tumors.
    Pediatric blood & cancer, 2012, Volume: 58, Issue:3

    Topics: Acute Kidney Injury; Benzoates; Brain Neoplasms; Child; Child, Preschool; Deferasirox; Erythrocyte Transfusion; Fanconi Syndrome; Female; Ferritins; Hepatic Veno-Occlusive Disease; Humans; Induction Chemotherapy; Infant; Iron Chelating Agents; Male; Neuroblastoma; Stem Cell Transplantation; Transplantation, Autologous; Triazoles

2012
Phase II clinical and pharmacologic study of radiation therapy and carboxyamido-triazole (CAI) in adults with newly diagnosed glioblastoma multiforme.
    Investigational new drugs, 2007, Volume: 25, Issue:3

    Topics: Administration, Oral; Adult; Aged; Anticonvulsants; Antineoplastic Agents; Brain Neoplasms; Calcium Channel Blockers; Case-Control Studies; Chemotherapy, Adjuvant; Drug Interactions; Glioblastoma; Humans; Kaplan-Meier Estimate; Middle Aged; Radiotherapy, Adjuvant; Treatment Outcome; Triazoles; United States

2007

Other Studies

43 other study(ies) available for triazoles and Brain Neoplasms

ArticleYear
A novel deep learning model DDU-net using edge features to enhance brain tumor segmentation on MR images.
    Artificial intelligence in medicine, 2021, Volume: 121

    Topics: Algorithms; Brain Neoplasms; Deep Learning; Humans; Image Processing, Computer-Assisted; Organophosphorus Compounds; Triazoles

2021
Regulation of the Receptor Tyrosine Kinase AXL in Response to Therapy and Its Role in Therapy Resistance in Glioblastoma.
    International journal of molecular sciences, 2022, Jan-17, Volume: 23, Issue:2

    Topics: Axl Receptor Tyrosine Kinase; Benzocycloheptenes; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Combined Modality Therapy; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Signal Transduction; Temozolomide; Triazoles; Tumor Hypoxia; Up-Regulation

2022
Enhanced activity of AZD5582 and SM-164 in rabies virus glycoprotein-lactoferrin-liposomes to downregulate inhibitors of apoptosis proteins in glioblastoma.
    Biomaterials advances, 2022, Volume: 133

    Topics: Alkynes; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Glioblastoma; Humans; Lactoferrin; Liposomes; Oligopeptides; Rabies virus; Triazoles

2022
Neuropharmacological Study of Posaconazole for Glioblastoma: A Phase 0 Clinical Trial Protocol.
    Neurosurgery, 2022, 10-01, Volume: 91, Issue:4

    Topics: Animals; Brain Neoplasms; Dialysis Solutions; Glioblastoma; Hexokinase; Lactates; Mice; Pyruvates; Triazoles

2022
De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma.
    Cancer cell, 2022, 09-12, Volume: 40, Issue:9

    Topics: Animals; Brain Neoplasms; Enzyme Inhibitors; Glioma; Isocitrate Dehydrogenase; Leukemia; Mice; Mutation; Pyrimidines; Salicylanilides; Triazoles

2022
Bromodomain inhibitor jq1 induces cell cycle arrest and apoptosis of glioma stem cells through the VEGF/PI3K/AKT signaling pathway.
    International journal of oncology, 2019, Volume: 55, Issue:4

    Topics: Animals; Azepines; Brain Neoplasms; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cell Survival; Gene Expression Regulation, Neoplastic; Glioma; Humans; Male; Mice; Neoplastic Stem Cells; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Transcription Factors; Triazoles; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays

2019
BET and Aurora Kinase A inhibitors synergize against MYCN-positive human glioblastoma cells.
    Cell death & disease, 2019, 11-21, Volume: 10, Issue:12

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aurora Kinase A; Azepines; Brain Neoplasms; Cell Line, Tumor; Drug Synergism; Female; Glioblastoma; Humans; Male; Middle Aged; N-Myc Proto-Oncogene Protein; Proteins; Temozolomide; Triazoles

2019
BET bromodomain inhibitor HMBA synergizes with MEK inhibition in treatment of malignant glioma.
    Epigenetics, 2021, Volume: 16, Issue:1

    Topics: Acetamides; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Azepines; Brain Neoplasms; Cell Line, Tumor; Drug Synergism; Glioma; Humans; Mice; Mitogen-Activated Protein Kinase Kinases; Protein Kinase Inhibitors; Rats; Transcription Factors; Triazoles

2021
Kinomic profile in patient-derived glioma cells during hypoxia reveals c-MET-PI3K dependency for adaptation.
    Theranostics, 2021, Volume: 11, Issue:11

    Topics: Animals; Antioxidants; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Glioblastoma; Glioma; Humans; Hypoxia; Male; Mice; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-met; Pyrazines; Pyrrolidinones; Quinolines; Signal Transduction; Temozolomide; Transcriptome; Triazoles

2021
BRD4 inhibition boosts the therapeutic effects of epidermal growth factor receptor-targeted chimeric antigen receptor T cells in glioblastoma.
    Molecular therapy : the journal of the American Society of Gene Therapy, 2021, 10-06, Volume: 29, Issue:10

    Topics: Animals; Azepines; Brain Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Combined Modality Therapy; Epigenesis, Genetic; ErbB Receptors; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Immunotherapy, Adoptive; Mice; Neoplasm Metastasis; Receptors, Chimeric Antigen; Transcription Factors; Triazoles; Xenograft Model Antitumor Assays

2021
Identification of Driver Genes and Key Pathways of Glioblastoma Shows JNJ-7706621 as a Novel Antiglioblastoma Drug.
    World neurosurgery, 2018, Volume: 109

    Topics: Adult; Apoptosis; Aurora Kinase A; Brain Neoplasms; Cell Cycle; Cell Line; Cell Line, Tumor; Cytoskeletal Proteins; Disease-Free Survival; Female; Flow Cytometry; Glioblastoma; Humans; In Vitro Techniques; Kinesins; Male; Microtubule-Associated Proteins; Molecular Targeted Therapy; Nuclear Proteins; Prognosis; Protein Interaction Maps; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Survival Rate; Transcriptome; Triazoles; Tumor Stem Cell Assay

2018
Activation of the Receptor Tyrosine Kinase AXL Regulates the Immune Microenvironment in Glioblastoma.
    Cancer research, 2018, 06-01, Volume: 78, Issue:11

    Topics: Animals; Apoptosis; Axl Receptor Tyrosine Kinase; Benzocycloheptenes; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Glioblastoma; Glioma; Humans; Male; Mice; Middle Aged; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Triazoles; Tumor Microenvironment; Xenograft Model Antitumor Assays

2018
Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles.
    Nature communications, 2018, 05-18, Volume: 9, Issue:1

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Apoptosis; Azepines; Blood-Brain Barrier; Brain Neoplasms; Cell Line, Tumor; Drug Delivery Systems; Glioma; Humans; Male; Mice; Mice, Inbred C57BL; Nanoparticles; Temozolomide; Triazoles; Xenograft Model Antitumor Assays

2018
The XPO1 Inhibitor Selinexor Inhibits Translation and Enhances the Radiosensitivity of Glioblastoma Cells Grown
    Molecular cancer therapeutics, 2018, Volume: 17, Issue:8

    Topics: Animals; Brain Neoplasms; Female; Glioblastoma; Humans; Hydrazines; Mice; Mice, Nude; Radiation Tolerance; Triazoles

2018
Getting to the brain.
    Nature nanotechnology, 2018, Volume: 13, Issue:7

    Topics: Animals; Antineoplastic Agents; Azepines; Blood-Brain Barrier; Brain; Brain Neoplasms; Drug Carriers; Drug Delivery Systems; Glioblastoma; Humans; Mice; Nanomedicine; Polyethylene Glycols; Temozolomide; Transferrin; Triazoles

2018
Synthesis of pyrazolo[3,4-d]pyrimidin-4(5H)-ones tethered to 1,2,3-triazoles and their evaluation as potential anticancer agents.
    European journal of medicinal chemistry, 2018, Aug-05, Volume: 156

    Topics: Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chemistry Techniques, Synthetic; Drug Screening Assays, Antitumor; Glioma; Humans; Molecular Docking Simulation; Protein Serine-Threonine Kinases; Pyrazoles; Pyrimidinones; Rats; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Triazoles

2018
Dual Inhibition of Bcl-2/Bcl-xL and XPO1 is synthetically lethal in glioblastoma model systems.
    Scientific reports, 2018, 10-18, Volume: 8, Issue:1

    Topics: Aniline Compounds; Animals; Antineoplastic Agents; Apoptosis; bcl-X Protein; Brain Neoplasms; Cell Proliferation; Drug Therapy, Combination; Exportin 1 Protein; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Hydrazines; Karyopherins; Mice; Mice, Nude; Proto-Oncogene Proteins c-bcl-2; Receptors, Cytoplasmic and Nuclear; Sulfonamides; Triazoles; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2018
TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets.
    Nature communications, 2018, 11-19, Volume: 9, Issue:1

    Topics: Antineoplastic Agents; Azepines; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; DNA Copy Number Variations; Epigenesis, Genetic; Forkhead Box Protein M1; Gene Expression Regulation, Neoplastic; HEK293 Cells; Histones; Humans; Kv Channel-Interacting Proteins; N-Myc Proto-Oncogene Protein; Neuroblastoma; Organoids; Panobinostat; Phenylenediamines; Pyrimidines; Repressor Proteins; Signal Transduction; T-Box Domain Proteins; Triazoles; Tumor Suppressor Protein p53

2018
Intensity-modulated radiation therapy with hypoxic sensitizer AK-2123 (sanazole) for glioblastoma multiforme using simultaneous integrated boost technique.
    Anticancer research, 2013, Volume: 33, Issue:4

    Topics: Brain Neoplasms; Chemoradiotherapy; Female; Glioblastoma; Humans; Hypoxia; Middle Aged; Prognosis; Radiation-Sensitizing Agents; Radiotherapy Planning, Computer-Assisted; Radiotherapy, Intensity-Modulated; Triazoles

2013
Hypofractionated stereotactic radiotherapy with the hypoxic sensitizer AK-2123 (sanazole) for reirradiation of brain metastases: a preliminary feasibility report.
    Anticancer research, 2013, Volume: 33, Issue:4

    Topics: Administration, Oral; Adult; Aged; Brain Neoplasms; Breast Neoplasms; Combined Modality Therapy; Cranial Irradiation; Dose Fractionation, Radiation; Feasibility Studies; Female; Humans; Lung Neoplasms; Male; Middle Aged; Prognosis; Radiation-Sensitizing Agents; Radiosurgery; Triazoles

2013
18F-AFETP, 18F-FET, and 18F-FDG imaging of mouse DBT gliomas.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2013, Volume: 54, Issue:7

    Topics: Alanine; Animals; Brain Neoplasms; Cell Line, Tumor; Fluorodeoxyglucose F18; Glioma; Male; Metabolic Clearance Rate; Mice; Mice, Inbred BALB C; Organ Specificity; Radionuclide Imaging; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Tissue Distribution; Triazoles; Tyrosine

2013
The pharmacokinetics of letrozole in brain and brain tumor in rats with orthotopically implanted C6 glioma, assessed using intracerebral microdialysis.
    Cancer chemotherapy and pharmacology, 2013, Volume: 72, Issue:2

    Topics: Algorithms; Animals; Antineoplastic Agents; Area Under Curve; Brain; Brain Neoplasms; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Extracellular Fluid; Female; Glioma; Humans; Letrozole; Microdialysis; Neoplasm Transplantation; Nitriles; Protein Binding; Rats; Rats, Sprague-Dawley; Triazoles

2013
[Effectiveness of the correction of hepatotoxicity during combined chemoradiotherapy for cancer patients].
    Voprosy onkologii, 2013, Volume: 59, Issue:4

    Topics: Adult; Aged; Brain Neoplasms; Breast Neoplasms; Chemical and Drug Induced Liver Injury; Chemoradiotherapy; Drug Administration Schedule; Female; Glioma; Humans; Infusions, Intravenous; Liver; Male; Middle Aged; Neoplasms; Protective Agents; Severity of Illness Index; Treatment Outcome; Triazoles

2013
[Long-term results of personalized treatment in 72 breast cancer patients who failed chemotherapy].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2013, Volume: 35, Issue:12

    Topics: Adult; Aged; Aromatase Inhibitors; Bone Density Conservation Agents; Bone Neoplasms; Brain Neoplasms; Breast Neoplasms; Carcinoma, Ductal, Breast; Chemotherapy, Adjuvant; Diphosphonates; Drugs, Chinese Herbal; Female; Follow-Up Studies; Humans; Imidazoles; Letrozole; Lung Neoplasms; Medicine, Chinese Traditional; Middle Aged; Neoplasm Staging; Nitriles; Radiotherapy, Adjuvant; Radiotherapy, Conformal; Remission Induction; Retrospective Studies; Survival Rate; Treatment Failure; Triazoles; Zoledronic Acid

2013
Synthesis of diethylamino-curcumin mimics with substituted triazolyl groups and their sensitization effect of TRAIL against brain cancer cells.
    Bioorganic & medicinal chemistry letters, 2014, Aug-01, Volume: 24, Issue:15

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Curcumin; Diethylamines; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Structure-Activity Relationship; TNF-Related Apoptosis-Inducing Ligand; Triazoles

2014
Pre-clinical analysis of changes in intra-cellular biochemistry of glioblastoma multiforme (GBM) cells due to c-Myc silencing.
    Cellular and molecular neurobiology, 2014, Volume: 34, Issue:7

    Topics: Animals; Azepines; Brain Neoplasms; Cell Line, Tumor; Down-Regulation; Gene Expression Regulation, Neoplastic; Gene Silencing; Glioblastoma; Glycogen; Immunohistochemistry; Lipid Metabolism; Male; Proto-Oncogene Proteins c-myc; Rats, Wistar; Survival Analysis; Triazoles

2014
Preclinical antitumor efficacy of selective exportin 1 inhibitors in glioblastoma.
    Neuro-oncology, 2015, Volume: 17, Issue:5

    Topics: Acrylamides; Active Transport, Cell Nucleus; Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Cycle Checkpoints; Cell Differentiation; Cell Line, Tumor; Dose-Response Relationship, Drug; Exportin 1 Protein; Glioblastoma; Humans; Hydrazines; Karyopherins; Macaca fascicularis; Male; Mice; Oxadiazoles; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Thiazoles; Treatment Outcome; Triazoles; Xenograft Model Antitumor Assays

2015
Small molecule inhibition of Axl receptor tyrosine kinase potently suppresses multiple malignant properties of glioma cells.
    Oncotarget, 2015, Jun-30, Volume: 6, Issue:18

    Topics: Adult; Apoptosis; Axl Receptor Tyrosine Kinase; Benzocycloheptenes; Blotting, Western; Brain Neoplasms; Cell Cycle; Cell Movement; Cell Proliferation; Glioma; Humans; Immunoenzyme Techniques; Intercellular Signaling Peptides and Proteins; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Real-Time Polymerase Chain Reaction; Receptor Protein-Tyrosine Kinases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Triazoles; Tumor Cells, Cultured

2015
EGFR Mutation Promotes Glioblastoma through Epigenome and Transcription Factor Network Remodeling.
    Molecular cell, 2015, Oct-15, Volume: 60, Issue:2

    Topics: Adult; Animals; Azepines; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Cell Transformation, Neoplastic; Child; Epigenesis, Genetic; ErbB Receptors; Forkhead Transcription Factors; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Glioblastoma; Humans; Mice; Mice, Nude; Mutation; Neoplasm Transplantation; Nerve Tissue Proteins; Signal Transduction; SOX9 Transcription Factor; Transcriptome; Triazoles

2015
Wnt/β-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance.
    Nature communications, 2015, Nov-25, Volume: 6

    Topics: Animals; Antineoplastic Agents; Benzeneacetamides; beta Catenin; Brain Neoplasms; Camptothecin; Celecoxib; Cisplatin; Colorectal Neoplasms; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Doxorubicin; Drug Resistance, Neoplasm; Flow Cytometry; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioma; Glucose-6-Phosphate Isomerase; Heterocyclic Compounds, 3-Ring; Humans; Immunoblotting; Immunohistochemistry; Irinotecan; Medulloblastoma; Mice; Neoplasm Transplantation; Neoplasms; Neuroblastoma; Pyrans; Pyrazines; Pyridines; Real-Time Polymerase Chain Reaction; Sulfones; Temozolomide; Triazoles; Tumor Suppressor Proteins; Vincristine; Wnt Proteins; Wnt Signaling Pathway

2015
Long-Term Disease-Free Survival in a Young Patient With Hormone Receptor-Positive Breast Cancer and Oligometastatic Disease in the Brain.
    Clinical breast cancer, 2016, Volume: 16, Issue:3

    Topics: Anastrozole; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Intraductal, Noninfiltrating; Carmustine; Chemoradiotherapy; Craniotomy; Cyclophosphamide; Decanoic Acids; Disease-Free Survival; Doxorubicin; Female; Humans; Leuprolide; Nitriles; Paclitaxel; Polyesters; Radiosurgery; Receptors, Estrogen; Triazoles; Young Adult

2016
CK2 inhibition induced PDK4-AMPK axis regulates metabolic adaptation and survival responses in glioma.
    Experimental cell research, 2016, 05-15, Volume: 344, Issue:1

    Topics: Adenosine Triphosphate; AMP-Activated Protein Kinases; Animals; Brain Neoplasms; Casein Kinase II; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cellular Senescence; Cyclic AMP Response Element-Binding Protein; Glioma; Glucose; Humans; Mice, Nude; Phenotype; Phosphorylation; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; RNA, Messenger; Signal Transduction; Sirtuin 1; Triazoles; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays

2016
Anti-GD2-ch14.18/CHO coated nanoparticles mediate glioblastoma (GBM)-specific delivery of the aromatase inhibitor, Letrozole, reducing proliferation, migration and chemoresistance in patient-derived GBM tumor cells.
    Oncotarget, 2017, Mar-07, Volume: 8, Issue:10

    Topics: Antibodies, Monoclonal; Antineoplastic Agents; Aromatase Inhibitors; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gangliosides; Glioblastoma; HeLa Cells; Humans; Immunotoxins; Lactic Acid; Letrozole; Nanoparticles; Nitriles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Transfection; Triazoles

2017
An orally bioavailable c-Met kinase inhibitor potently inhibits brain tumor malignancy and growth.
    Anti-cancer agents in medicinal chemistry, 2010, Volume: 10, Issue:1

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Biological Availability; Brain Neoplasms; Flow Cytometry; Glioblastoma; Humans; Mice; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Pyridazines; Triazoles

2010
Click synthesis and biologic evaluation of (R)- and (S)-2-amino-3-[1-(2-[18F]fluoroethyl)-1H-[1,2,3]triazol-4-yl]propanoic acid for brain tumor imaging with positron emission tomography.
    Molecular imaging, 2010, Volume: 9, Issue:6

    Topics: Alanine; Animals; Brain Neoplasms; Click Chemistry; Gliosarcoma; Humans; Positron-Emission Tomography; Propionates; Rats; Rats, Inbred F344; Subcutaneous Tissue; Time Factors; Tissue Distribution; Triazoles

2010
Rizatriptan is effective for headache in a patient with meningeal carcinomatosis.
    Journal of pain and symptom management, 2011, Volume: 41, Issue:5

    Topics: Brain Neoplasms; Female; Headache; Humans; Meningeal Carcinomatosis; Middle Aged; Serotonin Receptor Agonists; Treatment Outcome; Triazoles; Tryptamines

2011
[Cutaneous neutrophils infiltrates. Case 4. Pseudo-tumoral cutaneous alternariosis].
    Annales de pathologie, 2011, Volume: 31, Issue:3

    Topics: Aged, 80 and over; Alternaria; Antifungal Agents; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carcinoma, Verrucous; Combined Modality Therapy; Dacarbazine; Dermatomycoses; Diagnosis, Differential; Ependymoma; Fatal Outcome; Folliculitis; Frontal Lobe; Hand Dermatoses; Humans; Immunocompromised Host; Keratosis; Male; Neutrophils; Pyrimidines; Skin Neoplasms; Staining and Labeling; Temozolomide; Triazoles; Voriconazole

2011
[A case of recurrent breast cancer with brain metastases successfully treated with vinorelbine and anastrozole after multiple chemo-endocrine therapies].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2012, Volume: 39, Issue:3

    Topics: Anastrozole; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Breast Neoplasms; Female; Humans; Middle Aged; Nitriles; Receptors, Estrogen; Recurrence; Triazoles; Vinblastine; Vinorelbine

2012
Letrozole for brain and scalp metastases from breast cancer--a case report.
    Breast (Edinburgh, Scotland), 2006, Volume: 15, Issue:3

    Topics: Aromatase Inhibitors; Brain Neoplasms; Breast Neoplasms; Female; Head and Neck Neoplasms; Humans; Letrozole; Middle Aged; Nitriles; Scalp; Skin Neoplasms; Tomography, X-Ray Computed; Triazoles

2006
[Two patients having recurrent breast cancer with brain metastases well controlled with a gamma knife radio-surgery].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33, Issue:12

    Topics: Anastrozole; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Breast Neoplasms; Female; Hepatectomy; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Mastectomy; Middle Aged; Nitriles; Paclitaxel; Pleurisy; Pleurodesis; Radiosurgery; Triazoles

2006
Endogenous expression of adenosine A1, A2 and A3 receptors in rat C6 glioma cells.
    Neurochemical research, 2007, Volume: 32, Issue:6

    Topics: Adenylyl Cyclases; Animals; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Cell Membrane; Fluorescent Antibody Technique; Glioma; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; Molecular Sequence Data; Nerve Tissue Proteins; Protein Binding; Rats; Receptor, Adenosine A1; Receptor, Adenosine A3; Receptors, Adenosine A2; Reverse Transcriptase Polymerase Chain Reaction; Triazines; Triazoles; Xanthines

2007
Presence of specific platelet-activating factor binding-sites in neuroblastoma N1E-115 cells.
    Neuroscience letters, 1995, Feb-17, Volume: 186, Issue:2-3

    Topics: Animals; Azepines; Binding Sites; Binding, Competitive; Brain Neoplasms; Diterpenes; Ginkgolides; Kinetics; Lactones; Mice; Neuroblastoma; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thienopyridines; Triazoles; Tumor Cells, Cultured

1995
Inhibitory effects of CAI in glioblastoma growth and invasion.
    Journal of neuro-oncology, 1997, Volume: 32, Issue:2

    Topics: Antineoplastic Agents; Brain Neoplasms; Cell Adhesion; Cell Division; Gelatinases; Glioblastoma; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Metalloendopeptidases; Neoplasm Invasiveness; Triazoles; Tumor Cells, Cultured

1997