triazoles has been researched along with posaconazole in 1435 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 25 (1.74) | 18.2507 |
| 2000's | 371 (25.85) | 29.6817 |
| 2010's | 864 (60.21) | 24.3611 |
| 2020's | 175 (12.20) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, XP; Sugar, AM | 1 |
| Cox, GM; Dodge, RK; Perfect, JR; Schell, WA | 1 |
| Galgiani, JN; Lewis, ML | 1 |
| Jones, RN; Messer, S; Pfaller, MA | 1 |
| Denning, DW; Moore, CB; Oakley, KL | 1 |
| Denning, DW; Morrissey, G; Oakley, KL | 1 |
| Aristizabal, BH; Clemons, KV; Lutz, JE; Stevens, DA | 1 |
| Denning, DW; Law, D; Moore, CB | 1 |
| Contreras, LM; Liendo, A; Loebenberg, D; Molina, J; Payares, G; Perez, N; Piras, M; Piras, R; Sanoja, C; Urbina, JA; Wincker, P | 1 |
| Hitchcock, CA; Koltin, Y | 1 |
| Espinel-Ingroff, A | 3 |
| Cantu, RA; Fothergill, AW; Kirkpatrick, WR; Lopez-Ribot, JL; Mcatee, RK; McCarthy, DI; Patterson, TF; Revankar, SG; Rinaldi, MG; Sanche, SE | 1 |
| Jones, RN; Marco, F; Messer, SA; Pfaller, MA | 1 |
| Bocanegra, R; Graybill, JR; Loebenberg, D; Luther, MF; Najvar, LK | 2 |
| Baquero, F | 1 |
| Brandt, ME; Doern, GV; Hajjeh, RA; Hollis, RJ; Jones, RN; Messer, SA; Pfaller, MA | 1 |
| Brizendine, E; Connolly, P; Durkin, M; Goldberg, J; Kohler, S; Loebenberg, D; Schnizlein-Bick, C; Smedema, M; Wheat, J | 1 |
| Chandrasekar, PH; Cutright, J; Manavathu, EK | 1 |
| Coleman, DC; Gee, S; Joly, S; Messer, SA; Pfaller, MA; Pujol, C; Soll, DR; Sullivan, DJ | 1 |
| Anaissie, EJ; Arikan, S; Loebenberg, D; Lozano-Chiu, M; Paetznick, VL; Rex, JH | 1 |
| Urbina, JA | 2 |
| Matsushima, T; Nakajima, M; Niki, Y | 1 |
| Al-Abdely, HM; Graybill, JR; Loebenberg, D; Melby, PC | 1 |
| Brener, Z; Loebenberg, D; Martins-Filho, O; Molina, J; Romanha, AJ; Urbina, JA | 1 |
| Arzeni, D; Barchiesi, F; Caselli, F; Di Francesco, LF; Fothergill, AW; Rinaldi, MG; Scalise, G | 1 |
| Cacciapuoti, A; Cayen, MN; Gupta, S; Hare, R; Hilbert, MJ; Kumari, P; Lin, CC; Loebenberg, D; Miller, GH; Nomeir, AA | 1 |
| Fothergill, AW; Kirkpatrick, WR; Loebenberg, D; McAtee, RK; Patterson, TF; Rinaldi, MG | 1 |
| Al-Abdely, HM; Bocanegra, R; Fothergill, A; Graybill, JR; Loebenberg, D; Najvar, L; Rinaldi, MG | 1 |
| Kim, H; Kumari, P; Likhari, P; Lin, CC; Nomeir, AA | 1 |
| Fothergill, AW; Rinaldi, MG; Saracli, MA; Yildiran, ST | 1 |
| Heimark, L; Kim, H; Laughlin, M; Lin, CC; Lovey, R; Nomeir, AA; Saksena, A | 1 |
| Antonacci, B; Arnold, B; Cacciapuoti, A; Corcoran, E; Halpern, J; Hare, RS; Loebenberg, D; Mendrick, C; Menzel, F; Michalski, M; Miller, GH; Moss, EL; Norris, C; Parmegiani, R; Raynor, K; Yarosh-Tomaine, T | 1 |
| Chandrasekar, PH; Cutright, JL; Loebenberg, D; Manavathu, EK | 1 |
| Arzeni, D; Barchiesi, F; Carle, F; Caselli, F; Di Cesare, S; Di Francesco, LF; Fallani, S; Fortuna, M; Giacometti, A; Giannini, D; Mazzei, T; Novelli, A; Scalise, G; Schimizzi, AM | 1 |
| Brizendine, E; Connolly, P; Durkin, M; Goldberg, J; Kohler, S; Loebenberg, D; Schnizlein-Bick, C; Smedema, M; Wheat, LJ | 1 |
| Kou, JH; Saha, P | 1 |
| Avila, N; Bacher, J; Candelario, M; Field-Ridley, A; Groll, AH; Petraitiene, R; Petraitis, V; Piscitelli, S; Sein, T; Walsh, TJ | 1 |
| Barchiesi, F; Bocanegra, R; Carle, F; Caselli, F; Di Cesare, S; Di Francesco, LF; Giacometti, A; Giannini, D; Graybill, JR; Najvar, LK; Scalise, G; Schimizzi, AM | 1 |
| Abraham, OC; Chandrasekar, PH; Manavathu, EK | 1 |
| Bennett, F; Chan, TM; Chen, G; Feng, W; Lin, E; Liu, H; Malchow, R; Pramanik, B | 1 |
| Carrillo, AJ; Guarro, J | 1 |
| Uchida, K; Yamaguchi, H; Yokota, N | 1 |
| Mocherla, S; Wheat, LJ | 1 |
| Hollis, RJ; Jones, RN; Messer, SA; Pfaller, MA | 2 |
| Kim, H; Kumari, P; Lin, CC; Nomeir, AA | 1 |
| Bolmström, A; Jones, RN; Messer, SA; Mills, K; Pfaller, MA | 1 |
| Arzeni, D; Barchiesi, F; Camiletti, V; Cellini, A; Offidani, AM; Scalise, G; Simonetti, O | 1 |
| Barchiesi, F; Camiletti, V; Caselli, F; Di Francesco, LF; Fileni, B; Giacometti, A; Giannini, D; Scalise, G; Schimizzi, AM | 1 |
| Chandrasekar, PH; Cutright, JL; Manavathu, EK | 1 |
| Denning, DW; Mosquera, J | 1 |
| Arzeni, D; Barchiesi, F; D'Angelo, M; Falconi Di Francesco, L; Giuliana, G; Milici, ME; Pizzo, G; Scalise, G | 1 |
| DiDomenico, B; Greene, J; Hare, R; Heimark, L; Munayyer, H; Pramanik, BN; Shipkova, P; Yarosh-Tomaine, T | 1 |
| Bocanegra, R; González, GM; Graybill, JR; Loebenberg, D; Najvar, LK; Rinaldi, M; Tijerina, R | 1 |
| Boyken, L; Diekema, DJ; Hollis, RJ; Huynh, H; Messer, SA; Pfaller, MA | 1 |
| Mellinghoff, IK; Mukwaya, G; Schiller, GJ; Winston, DJ | 1 |
| Espinel-Ingroff, A; Rezusta, A | 1 |
| Gil-Lamaignere, C; Maloukou, A; Mosquera, J; Roilides, E; Walsh, TJ | 1 |
| Bocanegra, R; Graybill, JR; Loebenberg, D; Najvar, LK; Sun, QN | 1 |
| Dang, D; Graybill, JR; Nevarez, HL; Sponsel, WE | 1 |
| Habel, F; Hoban, D; Laverdiere, M; Restieri, C | 1 |
| Bastide, JM; Dannaoui, E; Grillot, R; Mallie, M; Meletiadis, J; Piens, MA; Rigoni, AL; Tortorano, AM; Viviani, MA | 1 |
| Chen, E; Ostrosky-Zeichner, L; Paetznick, VL; Paphitou, NI; Rex, JH; Rodriguez, JR | 1 |
| Fothergill, AW; Rinaldi, MG; Sutton, DA; Yildiran, ST | 1 |
| Campos, F; Fohrer, C; Herbrecht, R; Letscher-Bru, V; Natarajan-Ame, S; Waller, J; Zamfir, A | 1 |
| Boyken, L; Diekema, DJ; Hollis, RJ; Jones, RN; Messer, SA; Pfaller, MA | 1 |
| DiDomenico, B; Hare, RS; Li, X; Loebenberg, D; Mann, PA; McNicholas, PM; Mendrick, CA; Parmegiani, RM; Walker, SS; Wei, SQ | 1 |
| Cantón, E; Gil, J; Gobernado, M; Orero, A; Pemán, J; Rubio, MC; Viudes, A | 1 |
| Hilbert, MJ; Indelicato, SR; Kim, H; Kumari, P; Laughlin, M; Lim, J; Lin, CC; Nomeir, AA | 1 |
| Bocanegra, R; González, GM; Graybill, JR; Loebenberg, D; Najvar, LK; Rinaldi, MG; Tijerina, R | 1 |
| Kamei, K | 1 |
| Boyken, L; Diekema, DJ; Hollis, RJ; Messer, SA; Pfaller, MA | 1 |
| Arango, M; Fernández, D; Restrepo, A; Tobón, AM | 1 |
| Sutton, DA | 1 |
| Diekema, DJ; Hollis, RJ; Jones, RN; Messer, SA; Pfaller, MA | 1 |
| Batra, V; Courtney, R; Laughlin, M; Lim, J; Pai, S | 1 |
| Gupta, AK; Tomas, E | 1 |
| Benito, R; Gil, J; Ramírez de Ocáriz, I; Rezusta, A; Rubio Calvo, MC | 1 |
| Dannaoui, E; Loebenberg, D; Meis, JF; Verweij, PE | 1 |
| Brown, N; Chau, AS; DiDomenico, B; Hare, RS; Li, X; Loebenberg, D; López-Ribot, JL; McNicholas, PM; Mendrick, CA; Quindos, G; Ruesga, MT | 1 |
| Andes, D; Cacciapuoti, A; Conklin, R; Ezzet, F; Krishna, G; Loebenberg, D; Marchillo, K | 1 |
| Arechavala, A; Bianchi, MH; Helou, SH; Negroni, R; Petri, N; Robles, AM | 1 |
| Chau, AS; Loebenberg, D; Madison, V; McNicholas, PM; Palermo, RE; Xiao, L | 1 |
| Achanfuo-Yeboah, J; Alton, K; Chowdhury, S; Ghosal, A; Hapangama, N; Iannucci, R; Patrick, JE; Yuan, Y; Zbaida, S | 1 |
| Courtney, R; Laughlin, M; Lim, J; Radwanski, E; Wexler, D | 1 |
| Bocanegra, R; Cacciapuoti, A; Graybill, JR; Gurnani, M; Halpern, J; Hernandez, S; Loebenberg, D; Menzel, F; Najvar, LK | 1 |
| Courtney, R; Laughlin, M; Lim, J; Radwanski, E | 1 |
| Ashley, ED; Lodge, BA; Perfect, JR; Steele, MP | 1 |
| Boyken, L; Diekema, DJ; Hollis, RJ; Messer, SA; Pfaller, MA; Rice, C; Tendolkar, S | 1 |
| Banfield, C; Courtney, R; Laughlin, M; Lim, J; Richards, W; Wexler, D | 1 |
| Hahn, U; Küker, W; Lengerke, A | 1 |
| Chau, AS; Loebenberg, D; McNicholas, PM; Mendrick, CA; Sabatelli, FJ | 1 |
| Bocanegra, R; Graybill, JR; Johnson, E; Loebenberg, D; Najvar, LK | 1 |
| Bocanegera, R; Colombo, AL; Gonzalez, GM; Graybill, JR; Hernandez, S; McCarthy, DI; Najvar, LK | 1 |
| Brieland, JK; Cacciapuoti, A; Halpern, J; Hare, R; Jackson, C; Loebenberg, D; Menzel, F; Patera, AC | 1 |
| Kantoyiannis, DP; Kontoyiannis, DP; Lewis, RE | 1 |
| Alexopoulos, EC; Gaitanis, G; Kritikou, S; Velegraki, A | 1 |
| Herbrecht, R | 1 |
| Barchiesi, F; Carle, F; Giannini, D; Maracci, M; Scalise, G; Schimizzi, AM; Spreghini, E | 1 |
| Courtney, R; Flannery, B; Gohdes, M; Krieter, P; Martinho, M; Musick, T | 1 |
| Buysschaert, I; De Laere, E; De Man, R; Demuynck, H; Ide, L; Surmont, I; Verlinde, A | 1 |
| Afif, C; Bodey, GP; Boktour, MR; Chatzinikolaou, I; Cooksley, C; Hachem, RY; Kantarjian, HM; Kontoyiannis, DP; Perego, C; Raad, II | 1 |
| Chau, AS; Greene, JR; Hare, RS; Heimark, L; Loebenberg, D; Mann, PA; McNicholas, PM; Munayyer, HK; Palermo, RE; Yarosh-Tomaine, T | 1 |
| Avramidis, N; Gil-Lamaignere, C; Havlova, E; Kourounaki, L; Lekkas, S; Loebenberg, D; Maloukou, A; Roilides, E; Simitsopoulou, M | 1 |
| Clemons, KV; Imai, JK; Singh, G; Stevens, DA | 1 |
| Gavaldá, J; Lumbreras, C | 1 |
| Espinel-Ingroff, A; Jones, RN; Pfaller, MA | 1 |
| Arango, M; Correa, AL; de Bedout, C; Restrepo, A; Tobón, AM | 1 |
| Herbrecht, R; Kessler, R; Kravanja, C; Letscher-Bru, V; Meyer, MH; Waller, J | 1 |
| Courtney, R; Laughlin, M; Marbury, T; Martinho, M; Sansone, A; Smith, W; Statkevich, P; Swan, S | 1 |
| Courtney, R; Ezzet, F; Krishna, G; Laughlin, M; Lim, J; Wexler, D | 1 |
| Cacciapuoti, A; Gurnani, M; Halpern, J; Loebenberg, D; Norris, C; Patel, R | 1 |
| Adelson, ME; Mordechai, E; Trama, JP | 1 |
| Alonso, R; Carrillo-Muñoz, AJ; del Valle, O; Hernández-Molina, JM; Loebenberg, D; McNicholas, P; Quindós, G; Ruesga, M; Santos, P | 1 |
| Al-Abdely, HM; Al-Tawfiq, JA; Alkhunaizi, AM; Hassounah, M; Rinaldi, MG; Sutton, DA | 1 |
| Batra, R; Gupta, AK; Kohli, Y | 1 |
| Gil-Lamaignere, C; Hess, R; Heyn, K; Kappe, R; Müller, FM; Salvenmoser, S | 1 |
| Anderson, VL; Barnhart, LA; Holland, SM; Malech, HL; Segal, BH; Walsh, TJ | 1 |
| Anstead, GM; Berg, D; Corcoran, G; Graybill, JR; Lewis, J | 1 |
| Steinbach, WJ | 2 |
| Fothergill, AW; González, GM; Loebenberg, D; Rinaldi, MG; Sutton, DA | 1 |
| Keating, GM | 1 |
| Coco, BJ; Fothergill, AW; Kirkpatrick, WR; Oliveira, ER; Patterson, TF; Redding, SW | 1 |
| Barchiesi, F; Cuenca-Estrella, M; Espinel-Ingroff, A; Pfaller, MA; Rinaldi, M; Rodriguez-Tudela, JL; Verweij, PE | 1 |
| Jagirdar, J; Scott, RS; Sutton, DA | 1 |
| Groll, AH; Walsh, TJ | 2 |
| Alexander, BD; Dodds Ashley, ES | 1 |
| Besnard, M; Brugière, O; Dauriat, G; Dupont, B; Fournier, M; Groussard, O; Lesèche, G; Mal, H; Marrash-Chalha, R | 2 |
| Gilman, AL; Serrano, A; Skelley, J; Zwick, D | 1 |
| Bustamante, B; Chapman, S; Graybill, JR; Hardalo, CJ; Hare, RS; Negroni, R; Pappas, P; Pitisuttithum, P | 1 |
| Barchiesi, F; Cuenca-Estrella, M; Espinel-Ingroff, A; Fothergill, A; Pfaller, MA; Rinaldi, M; Rodriguez-Tudela, JL; Verweij, PE | 1 |
| Arvieux, C; Chapplain, JM; Tattevin, P | 1 |
| Espinel-Ingroff, A; Fothergill, A; Ghannoum, M; Manavathu, E; Ostrosky-Zeichner, L; Pfaller, M; Rinaldi, M; Schell, W; Walsh, T | 1 |
| Baker, CJ; Pannaraj, PS; Walsh, TJ | 1 |
| Amini, K; Garbino, J; Lew, D; Puppo, M; Richter, M; Uçkay, I | 1 |
| Clark, B; Foster, R; Green, S; Tunbridge, A | 1 |
| Correll, TA; Leather, HL; Meyer, CL; Schmalfuss, IM; Wingard, JR | 1 |
| Vazquez, JA | 2 |
| Bennett, F; Cacciapuoti, A; Ganguly, AK; Girijavallabhan, VM; Hare, RS; Jao, E; Liu, YT; Loebenberg, D; Lovey, RG; Menzel, F; Moss, E; Nomeir, A; Patel, NM; Pike, R; Pinto, P; Saksena, AK; Wang, H | 1 |
| Herrin, KV; Loebenberg, D; Miranda, A | 1 |
| Bethge, WA; Einsele, H; Hebart, H; Horger, M; Kanz, L; Kröber, SM; Schmalzing, M; Schumacher, U; Stuhler, G | 1 |
| Barfield, RC; Behm, FG; Burnette, K; Eldridge, P; Hale, GA; Handgretinger, R; Knapp, K | 1 |
| Alvarado, P; de Albornoz, MC; Díaz de Torres, E; Lucena, L; Mendoza, M | 1 |
| Chemaly, RF; Hachem, RY; Kontoyiannis, DP; Raad, II; Torres, HA | 1 |
| Abzug, MJ; Anstead, G; Corcoran, G; Gonzalez, CE; Greenberg, RN; Hare, R; Herbrecht, R; Kryscio, RJ; Langston, A; Marr, KA; Mullane, K; Raad, I; Revankar, SG; Schiller, G; Schuster, M; van Burik, JA; Wingard, JR | 1 |
| Burchardt, A; Corcoran, G; Cornely, OA; Courtney, R; Hachem, R; Kontoyiannis, DP; Krishna, G; Martinho, M; Raad, I; Töpelt, K; Ullmann, AJ; Wexler, D | 1 |
| Benaim, G; Burgos, JM; Caldera, AR; Colina, C; Concepcion, JL; Garcia-Marchán, Y; Leon-Rossell, A; Levin, M; Lira, R; Oldfield, E; Payares, G; Sanders, JM; Sanoja, C; Schijman, AG; Urbina, JA | 1 |
| Barchiesi, F; Bedini, A; Borghi, V; Codeluppi, M; Esposito, R; Guaraldi, G; Mussini, C; Rumpianesi, F; Venturelli, C | 1 |
| Buitrago, MJ; Cuenca-Estrella, M; Gomez-Lopez, A; Mellado, E; Monzon, A; Rodriguez-Tudela, JL | 1 |
| Aller, AI; Almeida, C; Cantón, E; Castro, C; López-Oviedo, E; Martín, C; Martín-Mazuelos, E; Pemán, JM; Ramirez, M | 1 |
| Corrado, ML; Hare, RS; Kontoyiannis, DP; Solomon, HF; van Burik, JA | 1 |
| Gogate, J; Greaves, W; Isaacs, R; Nieto, L; Northland, R; Sanne, I; Skiest, DJ; Vazquez, JA | 1 |
| Klotz, SA | 1 |
| Corcoran, G; Graybill, JR; Hachem, RY; Hare, R; Herbrecht, R; Kontoyiannis, DP; Raad, II | 1 |
| Calzetta, A; Kantesaria, B; Krishna, G; Rosenberg, MA; Saltzman, MA; Sansone-Parsons, A; Wexler, D | 1 |
| Anstead, GM; Graybill, JR; Martinez, M | 1 |
| Afif, C; Bustamante, AB; Cornely, OA; Gaona-Flores, V; Graham, DR; Graybill, JR; Greenberg, RN; Hadley, S; Langston, A; Negroni, R; Pedicone, L; Perfect, JR; Pitisuttithum, P; Raad, II; Restrepo, A; Schiller, G; Ullmann, AJ | 1 |
| Almeida, D; de Nazareth S L de Meirelles, M; Pereira, MC; Silva, DT; Urbina, JA | 1 |
| Anaissie, EJ; Dong, L; Gubbins, PO; Krishna, G; Martinho, M; Penzak, SR; Sansone-Parsons, A | 1 |
| Black, TA; Hare, R; Loebenberg, D; Mann, PA; McNicholas, PM; Mendrick, CA; Norris, CC; Patel, R; Sabatelli, F | 1 |
| Buitrago, MJ; Cuenca-Estrella, M; Garcia-Effron, G; Gomez-Lopez, A; Mellado, E; Rodriguez-Tudela, JL | 1 |
| Aperis, G; Mylonakis, E | 1 |
| Bal, AM | 1 |
| Chen, E; Ostrosky-Zeichner, L; Paetznick, VL; Rodriguez, JR; Sims, CR | 1 |
| Colson, YL; Marty, FM; Paul, S | 1 |
| Cacciapuoti, A; Halpern, J; Loebenberg, D; Mendrick, C; Norris, C; Patel, R | 1 |
| Cockerham, KP; Rutar, T | 1 |
| Bradsher, RW; Clark, B; Corcoran, G; Goldman, M; Graham, DR; Graybill, JR; Moore, T; Negroni, R; Pankey, G; Restrepo, A; Tobón, A | 1 |
| Archimandritis, A; Filiotou, A; Giannaris, M; Kaloterakis, A; Mitroussia, A; Pirounaki, M; Velegraki, A | 1 |
| Hayes, RN; Krishna, G; Shen, JX | 1 |
| Hayes, RN; Shen, JX; Tama, CI | 1 |
| Colpaert, C; De Decker, K; Ieven, M; Jorens, PG; Van Poucke, S; Vogelaers, D; Wojciechowski, M | 1 |
| Chryssanthou, E; Cuenca-Estrella, M | 1 |
| Hof, H | 1 |
| Arndt, M; Cornely, OA; Müller, C; Queckenberg, C; Theisohn, M | 1 |
| Cornely, OA; Karthaus, M | 1 |
| Atta, J; Bialek, R; Herrmann, S; Jacobi, V; Just-Nübling, G; Lambrecht, E; Rickerts, V | 1 |
| Becker, M; Beske, F; Klingebiel, T; Lambrecht, E; Lehrnbecher, T; Porto, L; Rickerts, V; Schuster, T; Sörensen, J | 1 |
| Belohradsky, BH; Costantino, F; Friederici, D; Jansson, A; Notheis, G; Reinhardt, D; Rosenecker, J; Schweinitz, DV; Seger, R; Tarani, L; Wintergerst, U | 1 |
| Behringer, K; Cornely, OA; Krüger, K; Kurzai, O; Töx, U; Vehreschild, JJ; Wickenhauser, C | 1 |
| Chau, AS; Chen, G; Mann, PA; McNicholas, PM | 1 |
| Aperis, G; Mylonakis, E; Spanakis, EK | 1 |
| Cano, J; Gené, J; Gilgado, F; Guarro, J; Serena, C | 1 |
| Proia, LA; Trenholme, GM | 1 |
| Denning, DW; Gardiner, RE; Howard, SJ; Moore, CB; Park, S; Perlin, DS; Webster, I | 1 |
| Barchiesi, F; Fothergill, AW; Giannini, D; Pisa, E; Rinaldi, MG; Santinelli, A; Scalise, G; Spreghini, E | 1 |
| Brown, S; Traczewski, M | 1 |
| Herron, J; Kantesaria, B; Krishna, G; Sansone-Parsons, A; Simon, J; Soni, P; Stoltz, R | 1 |
| Dierich, MP; Lass-Flörl, C; Lugger, H; Perkhofer, S | 1 |
| Chandrasekar, P; Corcoran, G; Donowitz, GR; Gogate, J; Graybill, R; Greene, RE; Hachem, R; Hadley, S; Hardalo, C; Herbrecht, R; Krishna, G; Langston, A; Louie, A; Patterson, TF; Pedicone, L; Perfect, JR; Raad, I; Ribaud, P; Segal, BH; Stevens, DA; van Burik, JA; Walsh, TJ; White, CS | 1 |
| Kantesaria, B; Krishna, G; Martinho, M; Pedicone, L; Sansone-Parsons, A | 1 |
| Alves, RO; Ferraz, ML; Gazzinelli, RT; Romanha, AJ; Urbina, JA | 2 |
| Anstead, GM; Boparai, N; Graybill, JR; Hare, R; Isaacs, R; Reynes, J; Skiest, DJ; Vazquez, JA; Ward, D | 1 |
| Boparai, N; Chandrasekar, P; Durrant, S; Greinix, H; Langston, A; Lipton, JH; Morais de Azevedo, W; Patino, H; Pedicone, L; Reddy, V; Tarantolo, SR; Ullmann, AJ; Vesole, DH | 1 |
| Angulo-Gonzalez, D; Cornely, OA; Goh, YT; Hardalo, C; Helfgott, D; Holowiecki, J; Maertens, J; Perfect, J; Petrini, M; Stockelberg, D; Suresh, R; Ullmann, AJ; Walsh, TJ; Winston, DJ | 1 |
| De Pauw, BE; Donnelly, JP | 1 |
| Hilts, A; Page, RL; Schwiesow, J | 1 |
| Beatty, RF; Edward, D; Levy, J; McCartney, DL; Springer, KL; Tu, EY | 1 |
| Gilbert, M; Laustsen, G; Wimett, L | 1 |
| Paugam, A | 1 |
| Boyken, LB; Diekema, DJ; Hollis, RJ; Kroeger, J; Messer, SA; Pfaller, MA; Tendolkar, S | 3 |
| Amoiridis, G; Kalmanti, M; Kondi, A; Mantadakis, E | 1 |
| Brandt, ME; Dionne-Odom, J; Ferguson, TD; Langston, A; Nolte, FS; Rinaldi, MG; Schniederjan, SD; Zimmer, SM | 1 |
| Kantesaria, B; Krishna, G; Mant, T; Parsons, A | 1 |
| Easley, C; Kauffman, CA; Kirkpatrick, P; Malani, AN | 1 |
| Grist, R; Knapp, CC; McNicholas, PM; Mendrick, C; Patel, R | 1 |
| Arthington-Skaggs, B; Ellis, D; Espinel-Ingroff, A; Fothergill, A; Gibbs, DL; Iqbal, N; Messer, S; Pfaller, MA; Rinaldi, M; Wang, A | 1 |
| Harkness, J; Marriott, D; Milliken, S; Stark, D | 1 |
| Almyroudis, NG; Fothergill, AW; Kusne, S; Rinaldi, MG; Sutton, DA | 1 |
| Senanayake, S | 1 |
| Kalnicky, C; Klein, J; Mullane, K; Rodriguez, T; Stiff, P; Toor, AA | 1 |
| Almyroudis, NG; Ball, D; Bambach, BJ; Battiwalla, M; Gupta, S; Kwon-Chung, J; McCarthy, PL; Paplham, P; Proefrock, AD; Segal, BH; Varma, A | 1 |
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| Eller, P; Gorkiewicz, G; Hatzl, S; Hoenigl, M; Krause, R; Metnitz, P; Pilz, S; Posch, F; Prattes, J; Prüller, F; Reisinger, AC; Rief, M; Rosenkranz, AR; Schilcher, G; Schoerghuber, M; Stradner, M; Toller, W; Valentin, T | 1 |
| DiPippo, AJ; Kontoyiannis, DP; McDaneld, PM; Tverdek, FP | 1 |
| Amidon, GE; Kataoka, M; Minami, K; Takagi, T; Yamashita, S | 1 |
| Couraud, S; Dannaoui, E; Déméautis, T; Devouassoux, G; Dupont, D; Durieu, I; Garnier, H; Kramer, R; Lina, B; Menotti, J; Persat, F; Rabodonirina, M; Reix, P; Sénéchal, A; Simon, L; Wallon, M | 1 |
| Butkiewicz, CD; Schlacks, S; Shubitz, LF; Vishkautsan, P; Worthing, KA | 1 |
| Hochstetler, LJ; Jones, SL; McKinzie, BP; Musick, KL; Norris, AM; Williams, FN | 1 |
| Otero, MJ; Peña-Lorenzo, D; Pérez-Blanco, JS; Rebollo, N; Sánchez-Hernández, JG; Vázquez-López, L; Zarzuelo-Castañeda, A | 1 |
| Panagopoulou, P; Roilides, E | 1 |
| Chen, J; Dang, YC; Kong, QT; Liu, F; Sang, H; Yuan, F | 1 |
| Nunes Rodrigues, TC; Vandenabeele, SI | 1 |
| Bouma, E; de Keyzer, C; Delang, L; Jacobs, S; Merits, A; Meutiawati, F; Overheul, GJ; Smit, JM; Taşköprü, E; Teppor, M; van Rij, RP; van Woudenbergh, E; Varghese, FS | 1 |
| Fang, JP; Wang, J; Zhang, YT; Zhou, DH | 1 |
| Chakrabarti, A; Patel, A; Patel, K; Shah, K | 1 |
| Bego, M; Cristofoletti, R; Patel, N; Rostami-Hodjegan, A | 1 |
| Gao, L; Sun, Y; Tan, L; Yang, J; Yao, Z; Zeng, T | 1 |
| Atas, U; Aydin Ersoy, M; Iltar, U; Salim, O; Turkoglu, EB; Yucel, OK | 1 |
| Aerts, R; Blijlevens, NMA; Brüggemann, RJM; Burger, D; Colbers, A; Jansen, AME; Maertens, JA; Muilwijk, EW; Ter Heine, R; van der Velden, WJFM; Verweij, PE | 1 |
| Davis, MR; Dieringer, TD; Schaenman, JM | 1 |
| Gilani, S; Nasr, SH; Sethi, S | 1 |
| Leong, R; O'Flynn, R; Straus, W; Waskin, H; Zhou, YP | 1 |
| Godinas, L; Spriet, I; Verfaillie, S; Verleden, GM; Vos, R | 1 |
| Chakraborty, S; Joe, G; Soman, R | 1 |
| Boelens, J; Brüggemann, RJ; Dreesen, E; Jacobs, C; Lormans, P; Nulens, E; Rijnders, B; Spriet, I; Van Daele, R; Vanderbeke, L; Verweij, PE; Wauters, J | 1 |
| Cao, J; Chen, D; Fang, Y; Hu, Y; Li, F; Li, S; Lu, Y; Pei, R; Wu, M; Ye, P | 1 |
| Becker, DP; Caulfield, TR; Durvasula, R; Goicoechea, S; Gupta, Y; Kempaiah, P; Mathur, R; Romero, JG | 1 |
| Dong, R; Fang, Y; Jin, W; Lin, N; Shan, Q; Shi, C; Wang, L; Xie, Y; Ye, J | 1 |
| Alexander, BD; Engemann, A; Johnson, MD; Rizzieri, D; Sarpong, E; Strand, AM; Wong, JR; Wu, Y | 1 |
| Bauer-Brandl, A; Brandl, M; Holzem, FL; Klein, S; Schaffland, JP; Stillhart, C; Weck, A | 1 |
| Bhanja, D; Connor, J; Mansouri, A; Neighbors, J; Zadeh, G | 1 |
| Adamu Bukari, AR; Chapel, M; Gerstein, AC; Kukurudz, RJ; Sidney, B; Sierhuis, R; Wonitowy, Q | 1 |
| Fujita, N; Kameoka, Y; Kitadate, A; Kobayashi, T; Miura, M; Nara, M; Sato, H; Takahashi, N; Yamashita, T; Yoshioka, T | 1 |
| Cai, Y; Chen, A; He, J; Ju, C; Li, S; Lian, Q; Wei, L; Xie, H; Zhao, B; Zhou, S | 1 |
| Huang, L; Liao, X; Lin, D; Shang, D; Wang, X; Wu, L; Yang, L; Yu, L; Zeng, Y; Zhang, J; Zhang, Y; Zi, J | 1 |
| Cai, YP; Huang, HP; Liu, MB; Wang, Y; Wu, XM; Xu, BH; Zhu, LE | 1 |
| Dhupad, S; Mahalle, NP; Melinkeri, S; Naik, SS; Narawade, S; Panchakshari, SP; Patwardhan, SA; Prayag, AP; Prayag, PS | 1 |
| Chen, K; Ding, Q; Huang, S; Li, X; Pei, Q; Sun, Z | 1 |
| de Almeida, C; de Greef, R; Fauchet, F; Hasegawa, C; Iwasa, T; Winchell, GA; Wrishko, RE; Yoshitsugu, H | 1 |
| Bodapati, ATS; Lavanya, K; Madku, SR; Reddy, RS; Sahoo, BK | 1 |
| Dong, Z; Shi, H; Shi, Y; Shu, Y; Yang, Y; Yi, Q | 1 |
| Hall, R; Kincaide, E; Levine, D; Sweiss, H | 1 |
| Epps, KL; Huang, A; Ilges, D; O'Connell, C; Stevens, RW | 1 |
| Brüggemann, RJ; Chen, L; Heijnen, AR; Knibbe, CAJ; Krekels, EHJ | 1 |
| Garner, LM; Gonzalez, D; McCann, S; McKinzie, CJ; Sinha, J; Wilson, WS | 1 |
| Gong, YH; Li, Y; Wei, XC; Xiao, X; Zhao, MF | 1 |
| Grandhi, A; Haider, S; Han, S; Klimko, N; Lee, DG; Maertens, JA; Ponce-de-León, A; Rahav, G; Ramirez-Sanchez, IC; Waskin, H; Winchell, GA; Wrishko, R | 1 |
| Chu, J; Tu, S; Wang, N; Xie, Z; Yang, L; Zhang, K | 1 |
| Bazydlo, L; Girton, M; Tomsig, J | 1 |
163 review(s) available for triazoles and posaconazole
| Article | Year |
|---|---|
The search for new triazole antifungal agents.
Topics: Antifungal Agents; Drugs, Investigational; Humans; Pyrimidines; Triazoles; Voriconazole | 1997 |
Chemotherapy of Chagas' disease: the how and the why.
Topics: Animals; Chagas Disease; Humans; Models, Chemical; Sterols; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 1999 |
[Present problems and future trend of antifungals for deep seated mycosis. Azole antifungal agents].
Topics: Animals; Antifungal Agents; Azoles; Dosage Forms; Drug Interactions; Drug Resistance, Microbial; Fungi; Humans; Pyrimidines; Thiazoles; Triazoles; Voriconazole | 1999 |
Treatment of histoplasmosis.
Topics: Amphotericin B; Antifungal Agents; Histoplasmosis; Humans; Triazoles | 2001 |
Acremonium strictum pulmonary infection in a leukemic patient successfully treated with posaconazole after failure of amphotericin B.
Topics: Acremonium; Administration, Oral; Amphotericin B; Antifungal Agents; Biopsy, Needle; Female; Follow-Up Studies; Humans; Immunocompromised Host; Lung Diseases, Fungal; Microbial Sensitivity Tests; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Assessment; Tomography, X-Ray Computed; Treatment Failure; Treatment Outcome; Triazoles | 2002 |
[Present status and future prospects of azole antifungal agents in Japan].
Topics: Antifungal Agents; Azoles; Cyclodextrins; Drug Design; Fluconazole; Forecasting; Itraconazole; Japan; Miconazole; Pyrimidines; Thiazoles; Triazoles; Voriconazole | 2002 |
Laboratory evaluation of new antifungal agents against rare and refractory mycoses.
Topics: Anti-Bacterial Agents; Antifungal Agents; Caspofungin; Echinocandins; Fungi; Humans; Lipopeptides; Microbial Sensitivity Tests; Mitosporic Fungi; Mycoses; Peptides; Peptides, Cyclic; Pyrimidines; Thiazoles; Triazoles; Voriconazole | 2002 |
New antifungal agents.
Topics: Administration, Oral; Anidulafungin; Anti-Bacterial Agents; Antifungal Agents; Caspofungin; Chemistry, Pharmaceutical; Drug Approval; Echinocandins; Humans; Lipopeptides; Macrolides; Mycoses; Peptides; Peptides, Cyclic; Pyrimidines; Thiazoles; Triazoles; Voriconazole | 2003 |
Posaconazole: a potent, extended-spectrum triazole anti-fungal for the treatment of serious fungal infections.
Topics: Antifungal Agents; Clinical Trials, Phase III as Topic; Drug Evaluation; Humans; Mycoses; Treatment Outcome; Triazoles | 2004 |
In vitro antifungal activities of anidulafungin and micafungin, licensed agents and the investigational triazole posaconazole as determined by NCCLS methods for 12,052 fungal isolates: review of the literature.
Topics: Anidulafungin; Antifungal Agents; Echinocandins; Fungi; Humans; Lipopeptides; Lipoproteins; Micafungin; Mycology; Peptides, Cyclic; Triazoles | 2003 |
[Invasive aspergillosis: clinical manifestations and treatment].
Topics: Amphotericin B; Antifungal Agents; Aspergillosis; Aspergillosis, Allergic Bronchopulmonary; Caspofungin; Dermatomycoses; Drug Therapy, Combination; Echinocandins; Humans; Immunocompromised Host; Immunologic Factors; Itraconazole; Lipopeptides; Neuroaspergillosis; Neutropenia; Peptides; Peptides, Cyclic; Pyrimidines; Respiratory Tract Infections; Triazoles; Voriconazole | 2003 |
Successful therapy of cerebral phaeohyphomycosis due to Ramichloridium mackenziei with the new triazole posaconazole.
Topics: Antifungal Agents; Ascomycota; Brain Diseases; Central Nervous System Fungal Infections; Humans; Male; Middle Aged; Mycoses; Treatment Outcome; Triazoles | 2005 |
Antifungal agents in children.
Topics: Age Factors; Amphotericin B; Anidulafungin; Antifungal Agents; Caspofungin; Chemistry, Pharmaceutical; Child; Clinical Trials as Topic; Drug Approval; Drug Resistance, Fungal; Echinocandins; Fluconazole; Flucytosine; Humans; Itraconazole; Lipopeptides; Lipoproteins; Micafungin; Mycoses; Patient Selection; Pediatrics; Peptides, Cyclic; Pyrimidines; Safety; Thiazoles; Triazoles; United States; Voriconazole | 2005 |
Posaconazole.
Topics: Animals; Antifungal Agents; Clinical Trials as Topic; Fungi; Humans; Mycoses; Triazoles | 2005 |
Posaconazole: clinical pharmacology and potential for management of fungal infections.
Topics: Animals; Antifungal Agents; Drug Resistance, Fungal; Fungi; Humans; Molecular Structure; Mycoses; Triazoles | 2005 |
Posaconazole.
Topics: Antifungal Agents; Clinical Trials as Topic; Fungi; Humans; Mycoses; Triazoles | 2005 |
Review of treatment of zygomycosis with posaconazole in a patient with acute myeloid leukemia.
Topics: Acute Disease; Amphotericin B; Antifungal Agents; Humans; Leukemia, Myeloid; Rhizopus; Triazoles; Zygomycosis | 2005 |
Posaconazole: a broad-spectrum triazole antifungal.
Topics: Antifungal Agents; Drug Resistance, Fungal; Fungi; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Mycoses; Treatment Outcome; Triazoles | 2005 |
Newer triazole antifungal agents: pharmacology, spectrum, clinical efficacy and limitations.
Topics: Animals; Antifungal Agents; Aspergillosis; Candidiasis; Cryptococcosis; Drug Administration Schedule; Drug Evaluation, Preclinical; Drug Resistance, Fungal; Drug Therapy, Combination; Humans; Pyrimidines; Randomized Controlled Trials as Topic; Thiazoles; Triazoles; Voriconazole | 2006 |
A new, broad-spectrum azole antifungal: posaconazole--mechanisms of action and resistance, spectrum of activity.
Topics: Antifungal Agents; Azoles; Drug Resistance, Fungal; Fungi; Humans; Microbial Sensitivity Tests; Triazoles | 2006 |
Antifungal efficacy and pharmacodynamics of posaconazole in experimental models of invasive fungal infections.
Topics: Animals; Antifungal Agents; Aspergillosis; Candidiasis; Disease Models, Animal; Humans; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Mycoses; Rabbits; Rats; Treatment Outcome; Triazoles | 2006 |
Second-line treatment in invasive mould infections.
Topics: Antifungal Agents; Aspergillosis; Humans; Mycoses; Salvage Therapy; Treatment Outcome; Triazoles; Zygomycosis | 2006 |
New agents for the treatment of fungal infections: clinical efficacy and gaps in coverage.
Topics: Antifungal Agents; Aspergillosis; Candidiasis; Caspofungin; Clinical Trials as Topic; Cryptococcosis; Echinocandins; Fever; Humans; Lipopeptides; Lipoproteins; Micafungin; Mycoses; Neutropenia; Peptides, Cyclic; Pyrimidines; Treatment Outcome; Triazoles; Voriconazole | 2006 |
[The latest data on posaconazole].
Topics: Adult; Animals; Antifungal Agents; Central Nervous System Fungal Infections; Chagas Cardiomyopathy; Clinical Trials as Topic; Drug Evaluation, Preclinical; Drug Resistance, Fungal; Humans; Immunocompromised Host; Mice; Mycoses; Premedication; Triazoles; Trypanocidal Agents | 2007 |
Posaconazole: a new broad-spectrum antifungal agent.
Topics: Animals; Antifungal Agents; Disease Models, Animal; Drug Resistance, Fungal; Fungi; Humans; Immunocompromised Host; Microbial Sensitivity Tests; Mycoses; Salvage Therapy; Triazoles | 2007 |
Changing epidemiology of rare mould infections: implications for therapy.
Topics: Antifungal Agents; Aspergillosis; Drug Resistance, Fungal; Fusarium; Humans; Mycoses; Pyrimidines; Scedosporium; Triazoles; Voriconazole; Zygomycosis | 2007 |
Antifungal agents.
Topics: Antifungal Agents; Drug Interactions; Drug Therapy, Combination; Echinocandins; Fluconazole; Flucytosine; Half-Life; Humans; Itraconazole; Mycoses; Naphthalenes; Pyrimidines; Terbinafine; Triazoles; Voriconazole | 2007 |
Posaconazole: an extended-spectrum triazole antifungal agent.
Topics: Administration, Oral; AIDS-Related Opportunistic Infections; Antifungal Agents; Aspergillosis; Candidiasis; Drug Resistance, Fungal; Graft vs Host Disease; Hematologic Neoplasms; Hematopoietic Stem Cell Transplantation; Humans; Mycoses; Tissue Distribution; Triazoles | 2007 |
Treatment of zygomycosis: current and new options.
Topics: Antifungal Agents; Drug Resistance, Fungal; Humans; Triazoles; Zygomycosis | 2008 |
A review of the new antifungals: posaconazole, micafungin, and anidulafungin.
Topics: Administration, Oral; Anidulafungin; Antifungal Agents; Dermatomycoses; Echinocandins; Humans; Infusions, Intravenous; Lipopeptides; Lipoproteins; Micafungin; Triazoles | 2007 |
Reviews of anti-infective agents: posaconazole: a broad-spectrum triazole antifungal agent.
Topics: Animals; Antifungal Agents; Candidiasis; Controlled Clinical Trials as Topic; Disease Models, Animal; Fungi; Humans; Microbial Sensitivity Tests; Mycoses; Triazoles | 2007 |
Mucormycosis peritonitis: more than 2 years of disease-free follow-up after posaconazole salvage therapy after failure of liposomal amphotericin B.
Topics: Amphotericin B; Antifungal Agents; Female; Humans; Kidney Failure, Chronic; Liposomes; Middle Aged; Mucormycosis; Peritoneal Dialysis; Peritonitis; Polycystic Kidney, Autosomal Dominant; Treatment Failure; Treatment Outcome; Triazoles | 2008 |
Broad-spectrum antifungal prophylaxis in patients with cancer at high risk for invasive mold infections: point.
Topics: Antifungal Agents; Fluconazole; Humans; Immunocompromised Host; Itraconazole; Mycoses; Myelodysplastic Syndromes; Neoplasms; Neutropenia; Risk Assessment; Triazoles | 2008 |
Broad-spectrum antifungal prophylaxis in patients with cancer at high risk for invasive mold infections: counterpoint.
Topics: Antifungal Agents; Antigens, Fungal; Aspergillosis; beta-Glucans; Enzyme-Linked Immunosorbent Assay; Humans; Immunocompromised Host; Mycoses; Neoplasms; Neutropenia; Proteoglycans; Risk Assessment; Tomography, X-Ray Computed; Triazoles | 2008 |
Therapeutic drug monitoring of antifungals: pharmacokinetic and pharmacodynamic considerations.
Topics: Antifungal Agents; Drug Monitoring; Fluconazole; Flucytosine; Humans; Itraconazole; Mycoses; Pyrimidines; Triazoles; Voriconazole | 2008 |
Posaconazole : a review of its use in the prophylaxis of invasive fungal infections.
Topics: Antifungal Agents; Aspergillosis; Candidiasis; Cost-Benefit Analysis; Drug Interactions; Drug Resistance, Fungal; Humans; In Vitro Techniques; Triazoles | 2008 |
Antifungal agents--clinical pharmacokinetics and drug interactions.
Topics: Amphotericin B; Antifungal Agents; Drug Interactions; Echinocandins; Humans; Itraconazole; Mycoses; Pyrimidines; Triazoles; Voriconazole | 2008 |
Primary cutaneous mucormycosis in a lung transplant recipient: case report and concise review of the literature.
Topics: Adult; Antifungal Agents; Debridement; Dermatomycoses; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Lung Transplantation; Male; Mucormycosis; Postoperative Complications; Rhizopus; Silicosis; Triazoles | 2008 |
Posaconazole: an oral triazole with an extended spectrum of activity.
Topics: Animals; Antifungal Agents; Clinical Trials as Topic; Drug Monitoring; Drug Resistance, Fungal; Humans; Microbial Sensitivity Tests; Mycoses; Risk Factors; Triazoles | 2008 |
Posaconazole for paediatric patients: status of development and future perspectives.
Topics: Adolescent; Adult; Antifungal Agents; Child; Child, Preschool; Humans; Mycoses; Triazoles | 2008 |
Invasive candidiasis in the ICU: evidence based and on the edge of evidence.
Topics: Amphotericin B; Antifungal Agents; Candida; Candidiasis; Cross Infection; Deoxycholic Acid; Drug Combinations; Drug Therapy, Combination; Echinocandins; Fluconazole; Humans; Intensive Care Units; Itraconazole; Pyrimidines; Risk Factors; Triazoles; Voriconazole | 2008 |
[Posaconazole: another triazole antifungal of the new generation?].
Topics: Antifungal Agents; Humans; Mycoses; Triazoles | 2008 |
Trichosporon mucoides fungemia in a liver transplant recipient: case report and review.
Topics: Antifungal Agents; Enterococcus faecium; Fatal Outcome; Fungemia; Humans; Immunosuppressive Agents; Liver Transplantation; Male; Middle Aged; Mycoses; Peritonitis; Postoperative Complications; Tacrolimus; Triazoles; Trichosporon; Vancomycin; Vancomycin Resistance | 2009 |
[Trends in development of new antifungal agents in Japan].
Topics: Antifungal Agents; Caspofungin; Clinical Trials as Topic; Drug Discovery; Echinocandins; Humans; Japan; Lipopeptides; Mycoses; Triazoles | 2008 |
Posaconazole: a new oral antifungal agent with an expanded spectrum of activity.
Topics: Antifungal Agents; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Interactions; Drug Monitoring; Drug Resistance, Fungal; Humans; Microbial Sensitivity Tests; Mycoses; Triazoles | 2009 |
Posaconazole's impact on prophylaxis and treatment of invasive fungal infections: an update.
Topics: Animals; Antifungal Agents; Disease Models, Animal; Drug Dosage Calculations; Drug Interactions; Drug Resistance, Fungal; Humans; Microbial Sensitivity Tests; Mycoses; Triazoles | 2009 |
The changing face of febrile neutropenia-from monotherapy to moulds to mucositis. Prevention of mould infections.
Topics: Antifungal Agents; Chemoprevention; Hematologic Neoplasms; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Mycoses; Neutropenia; Patient Isolation; Pyrimidines; Triazoles; Voriconazole | 2009 |
Diagnosis and treatment of aspergillosis in children.
Topics: Amphotericin B; Antifungal Agents; Aspergillosis; Caspofungin; Child; Echinocandins; Fungal Vaccines; Genomics; Humans; Immunocompromised Host; Lipopeptides; Micafungin; Pyrimidines; Risk Factors; Triazoles; Voriconazole | 2009 |
Recent advances in the management of mucormycosis: from bench to bedside.
Topics: Amphotericin B; Antifungal Agents; Benzoates; Case Management; Clinical Trials as Topic; Deferasirox; Drug Therapy, Combination; Echinocandins; Humans; Immunologic Factors; Mucormycosis; Polyenes; Triazoles | 2009 |
ZYGOMYCOSIS: current approaches to management of patients with haematological malignancies.
Topics: Amphotericin B; Antibiotic Prophylaxis; Antifungal Agents; Granulocytes; Hematologic Neoplasms; Humans; Hyperbaric Oxygenation; Iron Chelating Agents; Neutrophils; Risk Factors; Triazoles; Zygomycosis | 2009 |
Successful nonoperative management of gastrointestinal mucormycosis: novel therapy for invasive disease.
Topics: Amphotericin B; Antifungal Agents; Drug Therapy, Combination; Gastrointestinal Diseases; Humans; Male; Middle Aged; Mucor; Mucormycosis; Treatment Outcome; Triazoles | 2009 |
Fatal rhizopus pneumonia in allogeneic stem cell transplant patients despite posaconazole prophylaxis: two cases and review of the literature.
Topics: Antifungal Agents; Chemoprevention; Fatal Outcome; Hematopoietic Stem Cell Transplantation; Humans; Male; Middle Aged; Mucormycosis; Pneumonia; Rhizopus; Transplantation, Homologous; Triazoles | 2009 |
Tolerability and safety profile of posaconazole: evaluation of 18 controlled studies in healthy volunteers.
Topics: Adolescent; Aged; Animals; Antifungal Agents; Clinical Trials, Phase I as Topic; Dizziness; Dose-Response Relationship, Drug; Electrocardiography; Female; Headache; Humans; Liver Function Tests; Male; Middle Aged; Triazoles; Xerostomia; Young Adult | 2009 |
Disseminated zygomycosis with involvement of the central nervous system.
Topics: Absidia; Amphotericin B; Antifungal Agents; Brain; Central Nervous System Fungal Infections; Child, Preschool; Humans; Liver; Lung; Male; Mucormycosis; Spinal Cord; Triazoles | 2009 |
In vitro activity of antifungals against Zygomycetes.
Topics: Amphotericin B; Antifungal Agents; Echinocandins; Humans; Microbial Sensitivity Tests; Mucorales; Mucormycosis; Pyrimidines; Triazoles; Voriconazole | 2009 |
Current experience in treating invasive zygomycosis with posaconazole.
Topics: Amphotericin B; Antifungal Agents; Debridement; Humans; Triazoles; Zygomycosis | 2009 |
Hyperbaric oxygen therapy and other adjunctive treatments for zygomycosis.
Topics: Amphotericin B; Antifungal Agents; Caspofungin; Debridement; Echinocandins; Humans; Hyperbaric Oxygenation; Immunologic Factors; Lipopeptides; Oxygen; Triazoles; Zygomycosis | 2009 |
Primary antifungal prophylaxis in acute myeloblastic leukemia and myelodysplastic syndrome--still an open question?
Topics: Amphotericin B; Anti-Bacterial Agents; Antifungal Agents; Caspofungin; Clinical Trials as Topic; Drug Resistance, Fungal; Echinocandins; Fever; Humans; Leukemia, Myeloid, Acute; Lipopeptides; Medical Oncology; Mycoses; Myelodysplastic Syndromes; Triazoles | 2010 |
Onychomycosis.
Topics: Administration, Cutaneous; Administration, Oral; Antifungal Agents; Ciclopirox; Drug Administration Schedule; Drug Therapy, Combination; Fluconazole; Foot Dermatoses; Humans; Itraconazole; Mitosporic Fungi; Morpholines; Naphthalenes; Onychomycosis; Pyridones; Pyrimidines; Terbinafine; Thiazoles; Triazoles; Voriconazole | 2010 |
Traditional and emerging antifungal therapies.
Topics: Amphotericin B; Anidulafungin; Antifungal Agents; Caspofungin; Drug Therapy, Combination; Echinocandins; Fluconazole; Humans; Itraconazole; Lipopeptides; Micafungin; Pyrimidines; Triazoles; Voriconazole | 2010 |
Pharmacokinetic/pharmacodynamic profile of posaconazole.
Topics: Animals; Antifungal Agents; Area Under Curve; Biological Availability; Drug Interactions; Drug Resistance, Fungal; Food-Drug Interactions; Fungi; Humans; Mycoses; Triazoles | 2010 |
Conazoles.
Topics: Antifungal Agents; Fluconazole; Itraconazole; Ketoconazole; Miconazole; Molecular Structure; Pyrimidines; Structure-Activity Relationship; Triazoles; Voriconazole | 2010 |
Use of posaconazole in the treatment of invasive fungal infections.
Topics: Animals; Antifungal Agents; Clinical Trials as Topic; Drug Resistance, Fungal; Fungi; Graft vs Host Disease; Humans; Immunocompromised Host; Leukemia, Myeloid; Mice; Mycoses; Myelodysplastic Syndromes; Rabbits; Stem Cell Transplantation; Triazoles; United States | 2009 |
Development, clinical utility, and place in therapy of posaconazole for prevention and treatment of invasive fungal infections.
Topics: Animals; Antifungal Agents; Drug Resistance, Fungal; Fungi; Humans; Mycoses; Risk Factors; Triazoles | 2010 |
Therapeutic drug monitoring of voriconazole and posaconazole.
Topics: Antifungal Agents; Dose-Response Relationship, Drug; Drug Interactions; Drug Monitoring; Humans; Pyrimidines; Triazoles; Voriconazole | 2011 |
Posaconazole: a pharmacoeconomic review of its use in the prophylaxis of invasive fungal disease in immunocompromised hosts.
Topics: Antifungal Agents; Central Nervous System Fungal Infections; Drug Costs; Humans; Immunocompromised Host; Lung Diseases, Fungal; Triazoles | 2011 |
Successful treatment of cutaneous zygomycosis with intravenous amphotericin B followed by oral posaconazole in a multivisceral transplant recipient.
Topics: Administration, Oral; Adolescent; Amphotericin B; Antifungal Agents; Cunninghamella; Dermatomycoses; Female; Humans; Injections, Intravenous; Mucormycosis; Transplants; Triazoles | 2010 |
Pharmacology and metabolism of voriconazole and Posaconazole in the treatment of invasive aspergillosis: review of the literature.
Topics: Antifungal Agents; Drug Interactions; Humans; Invasive Pulmonary Aspergillosis; Pyrimidines; Triazoles; Voriconazole | 2011 |
Prophylaxis and treatment of invasive aspergillosis with voriconazole, posaconazole and caspofungin: review of the literature.
Topics: Amphotericin B; Antifungal Agents; Caspofungin; Clinical Trials as Topic; Drug Therapy, Combination; Echinocandins; Evidence-Based Medicine; Humans; Invasive Pulmonary Aspergillosis; Itraconazole; Lipopeptides; Pyrimidines; Risk Factors; Triazoles; Voriconazole | 2011 |
Posaconazole: a new antifungal weapon.
Topics: Antifungal Agents; Clinical Trials as Topic; Drug Interactions; Drug Resistance, Fungal; Humans; Immunocompromised Host; Kidney Diseases; Mycoses; Opportunistic Infections; Triazoles | 2011 |
Posaconazole: when and how? The clinician's view.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus; Candida; Candidiasis, Invasive; Clinical Trials, Phase III as Topic; Cryptococcosis; Cryptococcus neoformans; Drug Administration Schedule; Drug Interactions; Humans; Microbial Sensitivity Tests; Triazoles | 2012 |
Posaconazole for the treatment of mucormycosis.
Topics: Animals; Antifungal Agents; Disease Models, Animal; Female; Humans; Male; Mice; Microbial Sensitivity Tests; Mucorales; Mucormycosis; Treatment Outcome; Triazoles | 2011 |
Targeting Trypanosoma cruzi sterol 14α-demethylase (CYP51).
Topics: 14-alpha Demethylase Inhibitors; Antifungal Agents; Azoles; Catalytic Domain; Chagas Disease; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Humans; Protein Conformation; Substrate Specificity; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2011 |
Update in treatment of Chagas disease.
Topics: Chagas Disease; Chronic Disease; Humans; Immune Tolerance; Immunocompromised Host; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2011 |
Rapid induction of multiple resistance mechanisms in Aspergillus fumigatus during azole therapy: a case study and review of the literature.
Topics: Amino Acid Sequence; Amino Acid Substitution; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Cytochrome P-450 Enzyme System; Drug Resistance, Fungal; Female; Fungal Proteins; Genotype; Humans; Itraconazole; Microbial Sensitivity Tests; Middle Aged; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation Rate; Phenotype; Polymorphism, Single Nucleotide; Sputum; Time Factors; Triazoles | 2012 |
Triazole antifungal agents in invasive fungal infections: a comparative review.
Topics: Antifungal Agents; Fluconazole; Fungi; Humans; Itraconazole; Mycoses; Pyrimidines; Triazoles; Voriconazole | 2011 |
Posaconazole: the case for therapeutic drug monitoring.
Topics: Antifungal Agents; Drug Monitoring; Humans; Mycoses; Triazoles | 2012 |
Endophthalmitis caused by Phialophora verrucosa: a case report and literature review of Phialophora ocular infections.
Topics: Aged; Amphotericin B; Antifungal Agents; Caspofungin; Diabetes Mellitus, Type 2; Disease Susceptibility; Drug Resistance, Multiple, Fungal; Drug Therapy, Combination; Echinocandins; Endophthalmitis; Eye Enucleation; Eye Infections, Fungal; Glaucoma; Humans; Hypertension; Intravitreal Injections; Lipopeptides; Male; Phialophora; Pyrimidines; Triazoles; Vitrectomy; Voriconazole | 2012 |
[Antifungal therapy update: new drugs and medical uses].
Topics: Anidulafungin; Antifungal Agents; Aspergillosis; Candidiasis; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Early Diagnosis; Echinocandins; Humans; Immunocompromised Host; Lipopeptides; Micafungin; Mycoses; Randomized Controlled Trials as Topic; Salvage Therapy; Treatment Outcome; Triazoles | 2011 |
Posaconazole exposure-response relationship: evaluating the utility of therapeutic drug monitoring.
Topics: Animals; Antifungal Agents; Drug Monitoring; Humans; Mycoses; Triazoles | 2012 |
Targeting calcium homeostasis as the therapy of Chagas' disease and leishmaniasis - a review.
Topics: Amiodarone; Antiprotozoal Agents; Calcium; Chagas Disease; Homeostasis; Humans; Leishmania; Leishmaniasis; Phosphorylcholine; Triazoles; Trypanosoma brucei brucei; Trypanosoma cruzi | 2011 |
A mucormycosis case in a cirrhotic patient successfully treated with posaconazole and review of published literature.
Topics: Adolescent; Adult; Aged; Antifungal Agents; Diabetes Complications; Female; Humans; Liver Cirrhosis; Male; Middle Aged; Mucorales; Mucormycosis; Triazoles | 2012 |
[Azole resistance in Aspergillus fumigatus in the Netherlands--increase due to environmental fungicides?].
Topics: Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Azoles; Drug Resistance, Fungal; Environmental Microbiology; Fungicides, Industrial; Humans; Itraconazole; Microbial Sensitivity Tests; Netherlands; Pyrimidines; Triazoles; Voriconazole | 2012 |
Mucormycosis treated with posaconazole: review of 96 case reports.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antifungal Agents; Child; Child, Preschool; Humans; Middle Aged; Mucormycosis; Salvage Therapy; Triazoles | 2013 |
Invasive fungal infection in chronic granulomatous disease: insights into pathogenesis and management.
Topics: Antifungal Agents; Granulomatous Disease, Chronic; Humans; Itraconazole; Mycoses; Surgical Procedures, Operative; Triazoles | 2012 |
Making sense of posaconazole therapeutic drug monitoring: a practical approach.
Topics: Antifungal Agents; Drug Monitoring; Humans; Mycoses; Triazoles | 2012 |
Neuro-ophthalmology of invasive fungal sinusitis: 14 consecutive patients and a review of the literature.
Topics: Aged; Aged, 80 and over; Antifungal Agents; Cause of Death; Eye Infections, Fungal; Female; Fungi; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Mycoses; Pyrimidines; Retrospective Studies; Risk Factors; Sinusitis; Tomography, X-Ray Computed; Triazoles; Voriconazole | 2013 |
Pharmacoeconomic assessment of therapy for invasive aspergillosis.
Topics: Amphotericin B; Antifungal Agents; Aspergillosis; Clinical Trials as Topic; Cost-Benefit Analysis; Empirical Research; Humans; Length of Stay; Pyrimidines; Treatment Outcome; Triazoles; Voriconazole | 2013 |
Immunosuppression and Chagas disease: a management challenge.
Topics: Adult; Antiprotozoal Agents; Chagas Disease; Female; Humans; Immunocompromised Host; Male; Middle Aged; Nifurtimox; Nitroimidazoles; Opportunistic Infections; Triazoles; Trypanosoma cruzi | 2013 |
Safety of posaconazole.
Topics: Animals; Antifungal Agents; Chemistry, Pharmaceutical; Drug Interactions; Histamine H2 Antagonists; Humans; Mycoses; Nausea; Proton Pump Inhibitors; Triazoles | 2013 |
[Mucormycosis: therapeutic news].
Topics: Amphotericin B; Antifungal Agents; Debridement; Humans; Immunocompromised Host; Mucormycosis; Triazoles | 2013 |
Old and new: appropriate dosing for neonatal antifungal drugs in the nursery.
Topics: Amphotericin B; Antifungal Agents; Candidiasis; Deoxycholic Acid; Dose-Response Relationship, Drug; Drug Combinations; Echinocandins; Fluconazole; Humans; Infant, Newborn; Infant, Newborn, Diseases; Intensive Care Units, Neonatal; Neonatology; Pyrimidines; Triazoles; Voriconazole | 2013 |
Posaconazole therapeutic drug monitoring in the real-life setting: a single-center experience and review of the literature.
Topics: Academic Medical Centers; Administration, Oral; Adult; Age Factors; Aged; Antifungal Agents; Drug Monitoring; Female; Hematologic Diseases; Humans; Incidence; Male; Middle Aged; Multivariate Analysis; Mycoses; Prospective Studies; Risk Factors; Triazoles; Young Adult | 2013 |
Therapeutic drug monitoring of voriconazole and posaconazole for invasive aspergillosis.
Topics: Antifungal Agents; Aspergillosis; Aspergillus; Clinical Trials as Topic; Drug Administration Schedule; Drug Dosage Calculations; Drug Monitoring; Drug Resistance, Fungal; Humans; Pyrimidines; Triazoles; Voriconazole | 2013 |
Rhinocerebral zygomycosis with pansinusitis in a 14-year-old girl with type 1 diabetes: a case report and review of the literature.
Topics: Adolescent; Antifungal Agents; Blindness; Diabetes Mellitus, Type 1; Disease Progression; Electromyography; Female; Follow-Up Studies; Fungemia; Humans; Immunocompromised Host; Magnetic Resonance Imaging; Meningitis, Fungal; Nose Diseases; Opportunistic Infections; Rare Diseases; Risk Assessment; Severity of Illness Index; Treatment Outcome; Triazoles; Zygomycosis | 2013 |
Clinically relevant drug-drug interactions between antiretrovirals and antifungals.
Topics: AIDS-Related Opportunistic Infections; Alkynes; Anti-Retroviral Agents; Antifungal Agents; Benzoxazines; Carbamates; Cyclopropanes; Drug Interactions; Drug Monitoring; Echinocandins; Furans; HIV Infections; HIV Protease Inhibitors; Humans; Itraconazole; Mycoses; Organophosphates; Pyrimidines; Ritonavir; Sulfonamides; Triazoles; Voriconazole | 2014 |
Successful treatment of osseous blastomycosis without pulmonary or disseminated disease and review of the literature.
Topics: Antifungal Agents; Blastomyces; Blastomycosis; Bone Diseases; Humans; Male; Middle Aged; Treatment Outcome; Triazoles | 2014 |
Our 2014 approach to mucormycosis.
Topics: Amphotericin B; Antifungal Agents; Debridement; Humans; Immunocompromised Host; Mucorales; Mucormycosis; Triazoles | 2014 |
Exploring azole antifungal drug resistance in Aspergillus fumigatus with special reference to resistance mechanisms.
Topics: Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Azoles; Cholesterol; Cytochrome P-450 Enzyme System; Drug Resistance, Fungal; Fungal Proteins; Humans; Itraconazole; Microbial Sensitivity Tests; Mutation; Triazoles; Voriconazole | 2014 |
The role of azoles in the management of azole-resistant aspergillosis: from the bench to the bedside.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Dose-Response Relationship, Drug; Drug Monitoring; Drug Resistance, Multiple, Fungal; Drug Therapy, Combination; Humans; Microbial Sensitivity Tests; Models, Biological; Mutation; Translational Research, Biomedical; Triazoles; Voriconazole | 2014 |
Optimizing azole antifungal therapy in the prophylaxis and treatment of fungal infections.
Topics: Antibiotic Prophylaxis; Antifungal Agents; Dose-Response Relationship, Drug; Drug Monitoring; Humans; Itraconazole; Mycoses; Population Surveillance; Precision Medicine; Triazoles; Voriconazole | 2014 |
Survey of antifungal prophylaxis and fungal diagnostic tests employed in malignant haematology and haemopoietic stem cell transplantation (HSCT) in Australia and New Zealand.
Topics: Antifungal Agents; Aspergillosis; Australia; Chemoprevention; Consensus Development Conferences as Topic; Data Collection; Diagnostic Tests, Routine; Graft vs Host Disease; Hematologic Neoplasms; Hematopoietic Stem Cell Transplantation; Humans; New Zealand; Opportunistic Infections; Practice Guidelines as Topic; Pre-Exposure Prophylaxis; Triazoles | 2014 |
Consensus guidelines for optimising antifungal drug delivery and monitoring to avoid toxicity and improve outcomes in patients with haematological malignancy, 2014.
Topics: Antifungal Agents; Consensus; Drug Administration Schedule; Drug Delivery Systems; Drug Dosage Calculations; Drug Interactions; Drug Monitoring; Hematologic Neoplasms; Humans; Molecular Sequence Data; Mycoses; Opportunistic Infections; Practice Guidelines as Topic; Rehydration Solutions; Triazoles; Voriconazole | 2014 |
Posaconazole: a review of the gastro-resistant tablet and intravenous solution in invasive fungal infections.
Topics: Animals; Antifungal Agents; Chemistry, Pharmaceutical; Clinical Trials as Topic; Gastrointestinal Tract; Humans; Infusions, Intravenous; Mycoses; Tablets, Enteric-Coated; Triazoles | 2015 |
In brief: a new formulation of posaconazole (Noxafil).
Topics: Animals; Antifungal Agents; Aspergillosis; Candidiasis; Chemistry, Pharmaceutical; Humans; Triazoles | 2015 |
Review of the new delayed-release oral tablet and intravenous dosage forms of posaconazole.
Topics: Administration, Intravenous; Animals; Antifungal Agents; Biological Availability; Delayed-Action Preparations; Humans; Mycoses; Tablets; Triazoles | 2015 |
Eumycetoma and actinomycetoma--an update on causative agents, epidemiology, pathogenesis, diagnostics and therapy.
Topics: Actinomycetales; Actinomycetales Infections; Amputation, Surgical; Animals; Anti-Bacterial Agents; Antifungal Agents; Cytokines; Debridement; Diagnosis, Differential; Humans; Inflammation; Itraconazole; Madurella; Mycetoma; Naphthalenes; Terbinafine; Triazoles | 2015 |
Our 2015 approach to invasive pulmonary aspergillosis.
Topics: Antifungal Agents; Aspergillus; Bronchoalveolar Lavage Fluid; Chemoprevention; Fever of Unknown Origin; France; Galactose; Hospitals, University; Humans; Invasive Pulmonary Aspergillosis; Mannans; Microbial Sensitivity Tests; Radiography, Thoracic; Tomography, X-Ray Computed; Triazoles | 2015 |
Pharmacologic and clinical evaluation of posaconazole.
Topics: Animals; Antifungal Agents; Aspergillosis; Candidiasis; Chemistry, Pharmaceutical; Critical Illness; Delayed-Action Preparations; Humans; Mycoses; Triazoles | 2015 |
[Mucormycosis. Clinical cases and update].
Topics: Adolescent; Adult; Amphotericin B; Antifungal Agents; Fatal Outcome; Female; Humans; Male; Middle Aged; Mucormycosis; Rifampin; Risk Factors; Triazoles; Young Adult | 2014 |
Posaconazole: promising but problematic in practice in pediatric patients.
Topics: Adolescent; Antifungal Agents; Child; Child, Preschool; Female; Fungemia; Humans; Infant; Infant, Newborn; Male; Treatment Outcome; Triazoles | 2015 |
The use of posaconazole against Chagas disease.
Topics: Animals; Chagas Disease; Disease Models, Animal; Humans; Mice; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Endemic mycoses in patients with STAT3-mutated hyper-IgE (Job) syndrome.
Topics: Adolescent; Adult; Amphotericin B; Antifungal Agents; Child; Child, Preschool; Coccidioides; Coccidioidomycosis; Colon; Cryptococcosis; Cryptococcus; Duodenal Ulcer; Endemic Diseases; Female; Histoplasma; Histoplasmosis; Humans; Itraconazole; Job Syndrome; Male; Middle Aged; Mutation; STAT3 Transcription Factor; Treatment Outcome; Triazoles; United States | 2015 |
Role of Non-Culture-Based Tests, with an Emphasis on Galactomannan Testing for the Diagnosis of Invasive Aspergillosis.
Topics: Antifungal Agents; Aspergillosis; Aspergillus; beta-Glucans; Bronchoalveolar Lavage Fluid; Galactose; Humans; Mannans; Proteoglycans; Triazoles; Voriconazole | 2015 |
Invasive Aspergillosis: Epidemiology, Clinical Aspects, and Treatment.
Topics: Amphotericin B; Antifungal Agents; Aspergillosis; Combined Modality Therapy; Drug Therapy, Combination; Echinocandins; Hematopoietic Stem Cell Transplantation; Humans; Lung Transplantation; Magnetic Resonance Imaging; Risk Factors; Tomography, X-Ray Computed; Treatment Outcome; Triazoles; Voriconazole | 2015 |
Emergence of Azole Resistance in Aspergillus.
Topics: Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Azoles; Cytochrome P-450 Enzyme System; Drug Resistance, Fungal; Echinocandins; Fungal Proteins; Humans; Microbial Sensitivity Tests; Mutation; Triazoles; Voriconazole | 2015 |
Mucormycosis: New Developments into a Persistently Devastating Infection.
Topics: Amphotericin B; Antifungal Agents; Combined Modality Therapy; Debridement; Hematopoietic Stem Cell Transplantation; Humans; Lung Diseases, Fungal; Mucorales; Mucormycosis; Nitriles; Pyridines; Triazoles | 2015 |
Coccidioidomycosis: Recent Updates.
Topics: Antifungal Agents; Coccidioides; Coccidioidomycosis; Humans; Nitriles; Pneumonia; Pyridines; Risk Factors; Triazoles; Voriconazole | 2015 |
Posaconazole: Use in the Prophylaxis and Treatment of Fungal Infections.
Topics: Antifungal Agents; Drug Interactions; Drug Resistance, Fungal; Humans; Immunocompromised Host; Mycoses; Salvage Therapy; Transplant Recipients; Triazoles; United States; United States Food and Drug Administration | 2015 |
Network Meta-analysis and Pharmacoeconomic Evaluation of Fluconazole, Itraconazole, Posaconazole, and Voriconazole in Invasive Fungal Infection Prophylaxis.
Topics: Adult; Antifungal Agents; Aspergillus; Candida; Cost-Benefit Analysis; Female; Fluconazole; Hematopoietic Stem Cell Transplantation; Humans; Itraconazole; Leukemia, Myeloid, Acute; Male; Middle Aged; Models, Economic; Mycoses; Singapore; Survival Analysis; Triazoles; Voriconazole | 2016 |
Dosing of antifungal agents in obese people.
Topics: Amphotericin B; Antifungal Agents; Candidiasis, Invasive; Caspofungin; Echinocandins; Fluconazole; Humans; Lipopeptides; Micafungin; Mycoses; Nitriles; Obesity; Pyridines; Triazoles | 2016 |
Salvage Treatment of Mucormycosis Post-Liver Transplant With Posaconazole During Sirolimus Maintenance Immunosuppression.
Topics: Antifungal Agents; Female; Humans; Immunosuppressive Agents; Liver Transplantation; Maintenance Chemotherapy; Middle Aged; Mucormycosis; Salvage Therapy; Sirolimus; Treatment Outcome; Triazoles | 2017 |
Fusariosis in a Patient with Acute Myeloid Leukemia: A Case Report and Review of the Literature.
Topics: Adult; Amphotericin B; Antifungal Agents; Blood; Fatal Outcome; Fusariosis; Fusarium; Humans; Leukemia, Myeloid, Acute; Lung; Male; Microbial Sensitivity Tests; Microbiological Techniques; Radiography, Thoracic; Skin; Tomography, X-Ray Computed; Triazoles | 2016 |
Treatment of mucormycosis in transplant patients: role of surgery and of old and new antifungal agents.
Topics: Amphotericin B; Antifungal Agents; DNA, Fungal; Humans; Mucorales; Mucormycosis; Nitriles; Opportunistic Infections; Pyridines; Salvage Therapy; Transplant Recipients; Triazoles | 2016 |
Breaking the Mold: A Review of Mucormycosis and Current Pharmacological Treatment Options.
Topics: Amphotericin B; Anidulafungin; Antifungal Agents; Caspofungin; Debridement; Drug Resistance, Fungal; Echinocandins; Humans; Lipopeptides; Male; Micafungin; Middle Aged; Mucorales; Mucormycosis; Nitriles; Pyridines; Triazoles; Virulence | 2016 |
[Fungal peritonitis due to Rhodotorula mucilaginosa in a patient with automated peritoneal dialysis: Literature review].
Topics: Aged, 80 and over; Antifungal Agents; Catheter-Related Infections; Female; Humans; Peritoneal Dialysis; Peritonitis; Rhodotorula; Time Factors; Triazoles | 2016 |
Cunninghamella bertholletiae Infection in a HLA-Haploidentical Hematopoietic Stem Cell Transplant Recipient with Graft Failure: Case Report and Review of the Literature.
Topics: Adult; Amphotericin B; Antifungal Agents; Cunninghamella; Fatal Outcome; Graft Rejection; Hematopoietic Stem Cell Transplantation; Humans; Male; Microbiological Techniques; Microscopy; Mucormycosis; Thorax; Tomography, X-Ray Computed; Transplant Recipients; Triazoles | 2016 |
Treatment of Paecilomyces variotii pneumonia with posaconazole: case report and literature review.
Topics: Antifungal Agents; Female; Humans; Middle Aged; Mycoses; Paecilomyces; Pneumonia; Triazoles | 2016 |
Therapeutic Challenges of Hepatic Mucormycosis in Hematologic Malignancy: A Case Report and Review of the Literature.
Topics: Amphotericin B; Antifungal Agents; Chemotherapy, Adjuvant; Fatal Outcome; Female; Humans; Immunocompromised Host; Leukemia, Myeloid, Acute; Liver Diseases; Middle Aged; Mucormycosis; Risk Factors; Treatment Failure; Treatment Outcome; Triazoles | 2016 |
An update on the safety and interactions of antifungal drugs in stem cell transplant recipients.
Topics: Amphotericin B; Antifungal Agents; Dose-Response Relationship, Drug; Drug Interactions; Hematopoietic Stem Cell Transplantation; Humans; Invasive Fungal Infections; Nitriles; Pyridines; Triazoles | 2017 |
Voriconazole for prophylaxis of invasive fungal infections after allogeneic hematopoietic stem cell transplantation.
Topics: Antifungal Agents; Cost-Benefit Analysis; Drug Administration Schedule; Hematopoietic Stem Cell Transplantation; Humans; Invasive Fungal Infections; Practice Guidelines as Topic; Primary Prevention; Transplantation, Homologous; Triazoles; Voriconazole | 2017 |
Therapeutic drug monitoring for invasive mould infections and disease: pharmacokinetic and pharmacodynamic considerations.
Topics: Antifungal Agents; Biological Availability; Drug Monitoring; Fungi; Humans; Invasive Fungal Infections; Itraconazole; Nitriles; Pyridines; Triazoles; Voriconazole | 2017 |
Successful treatment of bilateral endogenous Fusarium solani endophthalmitis in a patient with acute lymphocytic leukaemia.
Topics: Amphotericin B; Antifungal Agents; Drug-Related Side Effects and Adverse Reactions; Endophthalmitis; Female; Fungemia; Fusariosis; Fusarium; Humans; Immunocompromised Host; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Treatment Outcome; Triazoles; Voriconazole | 2018 |
Primary prophylaxis of invasive fungal infections in patients with haematological malignancies: 2017 update of the recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society for Haematology and Medical Oncology (DGHO).
Topics: Antifungal Agents; Clinical Trials as Topic; Drug Monitoring; Hematology; Hematopoietic Stem Cell Transplantation; Humans; Immunocompromised Host; Induction Chemotherapy; Invasive Fungal Infections; Leukemia, Myeloid, Acute; Medical Oncology; Myelodysplastic Syndromes; Primary Prevention; Societies, Medical; Triazoles; Voriconazole | 2018 |
Disseminated cutaneous sporotrichosis presenting as a necrotic facial mass: Case and review.
Topics: Aged; Antifungal Agents; Diagnosis, Differential; Face; Female; Humans; Immunocompromised Host; Itraconazole; Necrosis; Sporothrix; Sporotrichosis; Triazoles | 2017 |
Gastric Mucormycosis in a Liver and Kidney Transplant Recipient: Case Report and Concise Review of Literature.
Topics: Adult; Amphotericin B; Antifungal Agents; Female; Humans; Immunocompromised Host; Kidney Transplantation; Liver Transplantation; Mucormycosis; Stomach Diseases; Triazoles | 2018 |
Dose adjustment of immunosuppressants during co-administration of posaconazole: a systematic review.
Topics: Drug Therapy, Combination; Heart Transplantation; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Lung Transplantation; Triazoles | 2018 |
Utility of posaconazole therapeutic drug monitoring and assessment of plasma concentration threshold for effective prophylaxis of invasive fungal infections: a meta-analysis with trial sequential analysis.
Topics: Antifungal Agents; Blood Chemical Analysis; Chemoprevention; Drug Monitoring; Humans; Invasive Fungal Infections; Mycoses; Predictive Value of Tests; Reproducibility of Results; Treatment Outcome; Triazoles | 2018 |
Primary Fungal Prophylaxis in Hematological Malignancy: a Network Meta-Analysis of Randomized Controlled Trials.
Topics: Antifungal Agents; Aspergillosis; Fever; Hematologic Neoplasms; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Invasive Fungal Infections; Network Meta-Analysis; Neutropenia; Opportunistic Infections; Randomized Controlled Trials as Topic; Triazoles | 2018 |
Posaconazole in immunocompromised pediatric patients.
Topics: Age Factors; Antifungal Agents; Child; Dose-Response Relationship, Drug; Drug Monitoring; Humans; Immunocompromised Host; Invasive Fungal Infections; Off-Label Use; Triazoles | 2018 |
Cutaneous Mucormycosis by Saksenaea vasiformis: An Unusual Case Report and Review of Literature.
Topics: Administration, Intravenous; Amphotericin B; Amputation, Surgical; Antifungal Agents; Debridement; Dermatomycoses; Female; Greece; Humans; Middle Aged; Mucorales; Mucormycosis; Thigh; Triazoles | 2019 |
European guidelines for primary antifungal prophylaxis in adult haematology patients: summary of the updated recommendations from the European Conference on Infections in Leukaemia.
Topics: Adult; Antifungal Agents; Congresses as Topic; Europe; Hematologic Diseases; Hematopoietic Stem Cell Transplantation; Humans; Immunocompromised Host; Invasive Fungal Infections; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Risk Factors; Triazoles | 2018 |
Contemporary management and clinical outcomes of mucormycosis: A systematic review and meta-analysis of case reports.
Topics: Administration, Intravenous; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Amphotericin B; Antifungal Agents; Combined Modality Therapy; Disease Management; Drug Therapy, Combination; Female; Humans; Itraconazole; Male; Middle Aged; Mucormycosis; Surgical Procedures, Operative; Survival Analysis; Treatment Outcome; Triazoles; Young Adult | 2019 |
Therapeutic tools for oral candidiasis: Current and new antifungal drugs.
Topics: Administration, Intravenous; Administration, Oral; Administration, Topical; Amphotericin B; Anidulafungin; Antifungal Agents; Azoles; Candidiasis, Oral; Caspofungin; Clotrimazole; Databases, Factual; Drug Interactions; Echinocandins; Fluconazole; Humans; Miconazole; Nitriles; Nystatin; Pyridines; Triazoles | 2019 |
Prophylaxis of mould infections.
Topics: Antifungal Agents; Hematologic Neoplasms; Humans; Immunocompromised Host; Invasive Fungal Infections; Mycoses; Triazoles | 2019 |
Multi-target drugs active against leishmaniasis: A paradigm of drug repurposing.
Topics: Amphotericin B; Antifungal Agents; Drug Repositioning; Drug Resistance, Fungal; Fluconazole; Humans; Itraconazole; Leishmaniasis; Molecular Targeted Therapy; Phosphorylcholine; Sterol 14-Demethylase; Triazoles; Voriconazole | 2019 |
Blastomycosis.
Topics: Amphotericin B; Antifungal Agents; Blastomyces; Blastomycosis; Humans; Immunocompromised Host; Itraconazole; Triazoles; Voriconazole | 2020 |
An overview of the available treatments for chronic cavitary pulmonary aspergillosis.
Topics: Amphotericin B; Antifungal Agents; Aspergillus fumigatus; Disease Management; Echinocandins; Humans; Itraconazole; Nitriles; Practice Guidelines as Topic; Pulmonary Aspergillosis; Pyridines; Triazoles; Voriconazole | 2020 |
Pharmacokinetics and Pharmacodynamics of Posaconazole.
Topics: Administration, Oral; Animals; Antifungal Agents; Aspergillosis; Drug Compounding; Humans; Injections, Intravenous; Triazoles | 2020 |
From bench to bedside: Perspectives on the utility of pharmacokinetics/pharmacodynamics in predicting the efficacy of antifungals in invasive candidiasis.
Topics: Amphotericin B; Animals; Antifungal Agents; Antimicrobial Stewardship; Candida; Candida albicans; Candida glabrata; Candida parapsilosis; Candida tropicalis; Candidiasis, Invasive; Echinocandins; Fluconazole; Flucytosine; Humans; Species Specificity; Triazoles; Voriconazole | 2020 |
Posaconazole in prophylaxis and treatment of invasive fungal infections: a pharmacokinetic, pharmacodynamic and clinical evaluation.
Topics: Antifungal Agents; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Drug Monitoring; Humans; Invasive Fungal Infections; Salvage Therapy; Triazoles | 2020 |
Antifungal prophylaxis and novel drugs in acute myeloid leukemia: the midostaurin and posaconazole dilemma.
Topics: Antifungal Agents; Chemoprevention; Drug Interactions; Drugs, Investigational; Humans; Invasive Fungal Infections; Leukemia, Myeloid, Acute; Prognosis; Staurosporine; Triazoles | 2020 |
How to interpret MICs of antifungal compounds according to the revised clinical breakpoints v. 10.0 European committee on antimicrobial susceptibility testing (EUCAST).
Topics: Amphotericin B; Antifungal Agents; Aspergillus; Candida; Fluconazole; Itraconazole; Microbial Sensitivity Tests; Practice Guidelines as Topic; Triazoles; Voriconazole | 2020 |
Fixed vs adjusted-dose benznidazole for adults with chronic Chagas disease without cardiomyopathy: A systematic review and meta-analysis.
Topics: Adult; Cardiomyopathies; Chagas Disease; Databases, Factual; Humans; Nifurtimox; Nitroimidazoles; Patient Safety; Randomized Controlled Trials as Topic; Treatment Outcome; Triazoles; Trypanosoma cruzi | 2020 |
Breakthrough Hormographiella aspergillata Infection in a Patient with Acute Myeloid Leukemia Receiving Posaconazole Prophylaxis: A Case Report and Review.
Topics: Agaricales; Antifungal Agents; Humans; Leukemia, Myeloid, Acute; Mycoses; Pneumonia, Necrotizing; Triazoles | 2020 |
Midostaurin in acute myeloid leukemia: current evidence and practical considerations in routine clinical use.
Topics: Aniline Compounds; Anthracyclines; Antifungal Agents; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Cytarabine; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Echinocandins; fms-Like Tyrosine Kinase 3; Forecasting; Hematopoietic Stem Cell Transplantation; Humans; Leukemia, Myeloid, Acute; Maintenance Chemotherapy; Mutation; Mycoses; Protein Kinase Inhibitors; Pyrazines; Randomized Controlled Trials as Topic; Recurrence; Staurosporine; Triazoles | 2020 |
Epidemiology, clinical features, diagnosis and treatment of cerebral mucormycosis in diabetic patients: A systematic review of case reports and case series.
Topics: Amphotericin B; Antifungal Agents; Brain Diseases; Deoxycholic Acid; Diabetes Complications; Diabetes Mellitus; Drug Combinations; Humans; Mucormycosis; Risk Factors; Triazoles | 2020 |
Disseminated Saksenaea infection in an immunocompromised host associated with a good clinical outcome: a case report and review of the literature.
Topics: Aged; Amphotericin B; Antifungal Agents; Granulomatosis with Polyangiitis; Humans; Immunocompromised Host; Male; Mucormycosis; Northern Territory; Triazoles | 2020 |
Pulmonary infection secondary to Blastobotrys raffinosifermentans in a cystic fibrosis patient: Review of the literature.
Topics: Adult; Amphotericin B; Antifungal Agents; Cystic Fibrosis; Female; Fluconazole; Genes, Fungal; Humans; Immunosuppression Therapy; Microbial Sensitivity Tests; Mycoses; Nitriles; Phylogeny; Pneumonia; Pyridines; Saccharomycetales; Triazoles | 2021 |
The double-edged sword of systemic corticosteroid therapy in viral pneumonia: A case report and comparative review of influenza-associated mucormycosis versus COVID-19 associated mucormycosis.
Topics: Adrenal Cortex Hormones; Adult; Amphotericin B; Antifungal Agents; COVID-19; Diabetes Complications; Female; Humans; Influenza, Human; Liposomes; Mucormycosis; Pneumonia, Viral; Triazoles | 2021 |
A Review of Population Pharmacokinetic Models of Posaconazole.
Topics: Adult; Antifungal Agents; Child; Humans; Proton Pump Inhibitors; Tablets; Triazoles | 2022 |
Progress of triazole antifungal agent posaconazole in individualized therapy.
Topics: Antifungal Agents; Drug Interactions; Drug Monitoring; Humans; Triazoles | 2022 |
Ileus induced by the combination of vinca alkaloids and posaconazole in a patient with acute lymphoblastic leukemia: a case report and literature review.
Topics: Adolescent; Antifungal Agents; Cyclophosphamide; Female; Humans; Ileus; Intestinal Obstruction; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Triazoles; Vinca Alkaloids; Vindesine | 2023 |
102 trial(s) available for triazoles and posaconazole
| Article | Year |
|---|---|
Chiral high-performance liquid chromatographic analysis of antifungal SCH 56592 and evaluation of its chiral inversion in animals and humans.
Topics: Animals; Antifungal Agents; Biotransformation; Calibration; Chromatography, High Pressure Liquid; Dogs; Humans; Macaca fascicularis; Male; Rats; Reproducibility of Results; Spectrometry, Fluorescence; Stereoisomerism; Triazoles | 2000 |
Pharmacokinetics, safety, and tolerability of oral posaconazole administered in single and multiple doses in healthy adults.
Topics: Adolescent; Adult; Antifungal Agents; Area Under Curve; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Male; Triazoles | 2003 |
Effect of food on the relative bioavailability of two oral formulations of posaconazole in healthy adults.
Topics: Administration, Oral; Adolescent; Adult; Antifungal Agents; Biological Availability; Cross-Over Studies; Food; Food-Drug Interactions; Humans; Male; Middle Aged; Tablets; Triazoles | 2004 |
Pharmacokinetics of posaconazole coadministered with antacid in fasting or nonfasting healthy men.
Topics: Adolescent; Adult; Antacids; Antifungal Agents; Biological Availability; Drug Interactions; Fasting; Female; Half-Life; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Triazoles | 2004 |
Effect of posaconazole on cytochrome P450 enzymes: a randomized, open-label, two-way crossover study.
Topics: Adult; Analysis of Variance; Cross-Over Studies; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; Triazoles | 2004 |
Disposition of posaconazole following single-dose oral administration in healthy subjects.
Topics: Adult; Antifungal Agents; Biotransformation; Chromatography, High Pressure Liquid; Feces; Glucuronides; Humans; Intestinal Absorption; Male; Mass Spectrometry; Spectrophotometry, Ultraviolet; Suspensions; Triazoles | 2004 |
Posaconazole pharmacokinetics, safety, and tolerability in subjects with varying degrees of chronic renal disease.
Topics: Administration, Oral; Alanine Transaminase; Area Under Curve; Aspartate Aminotransferases; Biological Availability; Creatinine; Dietary Fats; Drug Administration Schedule; Eating; Female; Half-Life; Humans; Kidney Failure, Chronic; Liver Function Tests; Male; Metabolic Clearance Rate; Middle Aged; Protein Binding; Renal Dialysis; Suspensions; Treatment Outcome; Triazoles | 2005 |
Oral bioavailability of posaconazole in fasted healthy subjects: comparison between three regimens and basis for clinical dosage recommendations.
Topics: Administration, Oral; Adult; Biological Availability; Cross-Over Studies; Drug Administration Schedule; Fasting; Humans; Male; Models, Biological; Triazoles | 2005 |
Posaconazole as salvage therapy in patients with chronic granulomatous disease and invasive filamentous fungal infection.
Topics: Adolescent; Adult; Antifungal Agents; Child; Female; Fungi; Granulomatous Disease, Chronic; Humans; Lung Diseases, Fungal; Male; Salvage Therapy; Triazoles | 2005 |
Activity of posaconazole in the treatment of central nervous system fungal infections.
Topics: Adolescent; Adult; Antifungal Agents; Central Nervous System Fungal Infections; Female; Humans; Male; Middle Aged; Salvage Therapy; Treatment Outcome; Triazoles | 2005 |
Posaconazole as salvage therapy for zygomycosis.
Topics: Administration, Oral; Adolescent; Adult; Aged; Antifungal Agents; Child; Female; Fungi; Humans; Immunocompromised Host; Male; Middle Aged; Treatment Outcome; Triazoles; Zygomycosis | 2006 |
Pharmacokinetics, safety, and efficacy of posaconazole in patients with persistent febrile neutropenia or refractory invasive fungal infection.
Topics: Adult; Aged; Antifungal Agents; Bone Marrow Transplantation; Female; Fever; Humans; Male; Middle Aged; Mycoses; Neutropenia; Triazoles | 2006 |
A multicenter randomized trial evaluating posaconazole versus fluconazole for the treatment of oropharyngeal candidiasis in subjects with HIV/AIDS.
Topics: Adult; Aged; AIDS-Related Opportunistic Infections; Antifungal Agents; Candida; Candidiasis; Candidiasis, Oral; Double-Blind Method; Ethnicity; Female; Fluconazole; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Pharyngeal Diseases; Probability; Treatment Outcome; Triazoles | 2006 |
Posaconazole as salvage treatment for invasive fusariosis in patients with underlying hematologic malignancy and other conditions.
Topics: Adult; Aged; Amphotericin B; Antifungal Agents; Female; Fusarium; Humans; Leukemia; Male; Middle Aged; Mycoses; Retrospective Studies; Salvage Therapy; Treatment Outcome; Triazoles | 2006 |
Effect of a nutritional supplement on posaconazole pharmacokinetics following oral administration to healthy volunteers.
Topics: Administration, Oral; Adult; Antifungal Agents; Area Under Curve; Biological Availability; Cross-Over Studies; Dietary Supplements; Fasting; Female; Humans; Male; Middle Aged; Triazoles | 2006 |
Safety of long-term oral posaconazole use in the treatment of refractory invasive fungal infections.
Topics: Adolescent; Adult; Aged; Antifungal Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Mycoses; Triazoles | 2006 |
Salvage treatment of histoplasmosis with posaconazole.
Topics: Adolescent; Adult; Aged, 80 and over; Antifungal Agents; Cerebrospinal Fluid; Ethmoid Sinusitis; Female; Histoplasma; Histoplasmosis; Humans; Lung Diseases, Fungal; Male; Maxillary Sinusitis; Meningitis, Fungal; Middle Aged; Salvage Therapy; Treatment Outcome; Triazoles | 2007 |
Treatment of invasive aspergillosis with posaconazole in patients who are refractory to or intolerant of conventional therapy: an externally controlled trial.
Topics: Antifungal Agents; Aspergillosis; Aspergillus; Humans; Logistic Models; Salvage Therapy; Treatment Outcome; Triazoles | 2007 |
Posaconazole plasma concentrations in juvenile patients with invasive fungal infection.
Topics: Adolescent; Adult; Antifungal Agents; Aspergillosis; Body Surface Area; Body Weight; Child; Female; Humans; Male; Mycoses; Treatment Outcome; Triazoles | 2007 |
Posaconazole for the treatment of azole-refractory oropharyngeal and esophageal candidiasis in subjects with HIV infection.
Topics: Administration, Oral; Adult; AIDS-Related Opportunistic Infections; Candidiasis; Candidiasis, Oral; Confidence Intervals; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance, Fungal; Esophageal Diseases; Female; Fluconazole; Follow-Up Studies; Humans; Itraconazole; Male; Middle Aged; Probability; Severity of Illness Index; Treatment Failure; Treatment Outcome; Triazoles | 2007 |
Posaconazole or fluconazole for prophylaxis in severe graft-versus-host disease.
Topics: Adolescent; Adult; Aged; Antifungal Agents; Aspergillosis; Double-Blind Method; Female; Fluconazole; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Mycoses; Opportunistic Infections; Risk Factors; Triazoles | 2007 |
Posaconazole vs. fluconazole or itraconazole prophylaxis in patients with neutropenia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antifungal Agents; Antineoplastic Agents; Female; Fluconazole; Humans; Itraconazole; Kaplan-Meier Estimate; Leukemia, Myeloid, Acute; Male; Middle Aged; Mycoses; Myelodysplastic Syndromes; Neutropenia; Opportunistic Infections; Single-Blind Method; Treatment Outcome; Triazoles | 2007 |
Evaluation of the pharmacokinetics of posaconazole and rifabutin following co-administration to healthy men.
Topics: Administration, Oral; Adult; Anti-Bacterial Agents; Antifungal Agents; Area Under Curve; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Evaluation Studies as Topic; Humans; Male; Prospective Studies; Reference Values; Rifabutin; Risk Assessment; Sensitivity and Specificity; Triazoles | 2007 |
Effect of oral posaconazole on the pharmacokinetics of cyclosporine and tacrolimus.
Topics: Adult; Antifungal Agents; Area Under Curve; Cross-Over Studies; Cyclosporine; Drug Interactions; Drug Monitoring; Female; Heart Transplantation; Humans; Immunosuppressive Agents; Male; Middle Aged; Tacrolimus; Triazoles | 2007 |
Drug interaction assessment following concomitant administration of posaconazole and phenytoin in healthy men.
Topics: Administration, Oral; Adolescent; Adult; Anticonvulsants; Antifungal Agents; Drug Administration Schedule; Drug Interactions; Humans; Male; Middle Aged; Phenytoin; Polypharmacy; Time Factors; Triazoles | 2007 |
Posaconazole therapy for chronic refractory coccidioidomycosis.
Topics: Administration, Oral; Adult; Aged; Antifungal Agents; Chronic Disease; Coccidioidomycosis; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Treatment Outcome; Triazoles | 2007 |
Safety, tolerance, and efficacy of posaconazole therapy in patients with nonmeningeal disseminated or chronic pulmonary coccidioidomycosis.
Topics: Adult; Aged; Antifungal Agents; Coccidioidomycosis; Female; Humans; Lung Diseases, Fungal; Male; Middle Aged; Recurrence; Severity of Illness Index; Treatment Outcome; Triazoles | 2007 |
Pharmacokinetics of oral posaconazole in allogeneic hematopoietic stem cell transplant recipients with graft-versus-host disease.
Topics: Acute Disease; Adolescent; Adult; Age Factors; Aged; Antifungal Agents; Body Weight; Chronic Disease; Diarrhea; Double-Blind Method; Female; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Male; Middle Aged; Mycoses; Opportunistic Infections; Racial Groups; Sex Factors; Transplantation, Homologous; Triazoles | 2007 |
Novel antifungal agents as salvage therapy for invasive aspergillosis in patients with hematologic malignancies: posaconazole compared with high-dose lipid formulations of amphotericin B alone or in combination with caspofungin.
Topics: Adult; Amphotericin B; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Aspergillosis; Caspofungin; Combined Modality Therapy; Drug Combinations; Drug Therapy, Combination; Echinocandins; Female; Fungemia; Hematologic Neoplasms; Hematopoietic Stem Cell Transplantation; Humans; Itraconazole; Lipopeptides; Male; Middle Aged; Neutropenia; Phosphatidylcholines; Phosphatidylglycerols; Pyrimidines; Salvage Therapy; Treatment Outcome; Triazoles; Voriconazole | 2008 |
Pharmacokinetics of oral posaconazole in neutropenic patients receiving chemotherapy for acute myelogenous leukemia or myelodysplastic syndrome.
Topics: Administration, Oral; Adolescent; Adult; Aged; Antifungal Agents; Antineoplastic Agents; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Mycoses; Myelodysplastic Syndromes; Neutropenia; Prospective Studies; Single-Blind Method; Triazoles; Young Adult | 2008 |
Posaconazole as salvage treatment of invasive fungal infections in patients with underlying renal impairment.
Topics: Adult; Antifungal Agents; Aspergillosis; Female; Humans; Male; Middle Aged; Renal Insufficiency; Salvage Therapy; Treatment Outcome; Triazoles | 2008 |
Intrapulmonary pharmacokinetics and pharmacodynamics of posaconazole at steady state in healthy subjects.
Topics: Adult; Antifungal Agents; Area Under Curve; Aspergillus; Bronchoalveolar Lavage Fluid; Bronchoscopy; Epithelium; Female; Humans; Lung; Male; Microbial Sensitivity Tests; Middle Aged; Protein Binding; Pulmonary Alveoli; Triazoles; Young Adult | 2009 |
Pharmacokinetics and absorption of posaconazole oral suspension under various gastric conditions in healthy volunteers.
Topics: Administration, Oral; Adult; Anti-Ulcer Agents; Antifungal Agents; Area Under Curve; Black or African American; Carbonated Beverages; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Eating; Fasting; Female; Food-Drug Interactions; Gastric Mucosa; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Male; Middle Aged; Omeprazole; Suspensions; Triazoles; White People; Young Adult | 2009 |
Effects of oral posaconazole on the pharmacokinetics of sirolimus.
Topics: Administration, Oral; Adolescent; Adult; Antifungal Agents; Area Under Curve; Female; Humans; Immunosuppressive Agents; Male; Middle Aged; Reference Values; Sirolimus; Triazoles; Young Adult | 2009 |
Effects of oral posaconazole on the pharmacokinetic properties of oral and intravenous midazolam: a phase I, randomized, open-label, crossover study in healthy volunteers.
Topics: Adult; Anti-Anxiety Agents; Antifungal Agents; Area Under Curve; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Female; Half-Life; Humans; Injections, Intravenous; Ketoconazole; Male; Midazolam; Middle Aged; Triazoles | 2009 |
Pharmacokinetics of posaconazole administered orally or by nasogastric tube in healthy volunteers.
Topics: Administration, Oral; Adolescent; Adult; Antifungal Agents; Cross-Over Studies; Female; Humans; Intubation, Gastrointestinal; Male; Middle Aged; Triazoles; Young Adult | 2009 |
Effects of oral posaconazole on the pharmacokinetics of atazanavir alone and with ritonavir or with efavirenz in healthy adult volunteers.
Topics: Administration, Oral; Adult; Alkynes; Anti-HIV Agents; Area Under Curve; Atazanavir Sulfate; Benzoxazines; Cross-Over Studies; Cyclopropanes; Drug Interactions; Female; Humans; Male; Middle Aged; Oligopeptides; Pyridines; Ritonavir; Triazoles | 2009 |
Effect of varying amounts of a liquid nutritional supplement on the pharmacokinetics of posaconazole in healthy volunteers.
Topics: Adult; Antifungal Agents; Biological Availability; Cross-Over Studies; Female; Food; Humans; Male; Triazoles | 2009 |
Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species.
Topics: Adolescent; Adult; Aged; Antifungal Agents; Candida; Candida albicans; Candida glabrata; Candidiasis; Female; Fluconazole; Humans; Itraconazole; Male; Microbial Sensitivity Tests; Middle Aged; Phylogeny; Triazoles; Young Adult | 2009 |
Population pharmacokinetics of posaconazole in neutropenic patients receiving chemotherapy for acute myelogenous leukemia or myelodysplastic syndrome.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibiotic Prophylaxis; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Mycoses; Myelodysplastic Syndromes; Neutropenia; Population; Single-Blind Method; Triazoles; Young Adult | 2010 |
Skin concentrations and pharmacokinetics of posaconazole after oral administration.
Topics: Administration, Oral; Adult; Antifungal Agents; Biopsy; Dermatomycoses; Female; Humans; Male; Middle Aged; Onychomycosis; Reference Values; Skin; Triazoles | 2010 |
Economic evaluation of posaconazole versus fluconazole prophylaxis in patients with graft-versus-host disease (GVHD) in the Netherlands.
Topics: Adult; Double-Blind Method; Female; Fluconazole; Graft vs Host Disease; Humans; Male; Models, Economic; Netherlands; Quality-Adjusted Life Years; Triazoles | 2010 |
Intracellular concentrations of posaconazole in different compartments of peripheral blood.
Topics: Adult; Aged; Antifungal Agents; Drug Administration Schedule; Erythrocytes; Female; Humans; Leukocytes, Mononuclear; Male; Middle Aged; Neutrophils; Triazoles | 2010 |
Efficacy, safety, and breakthrough infections associated with standard long-term posaconazole antifungal prophylaxis in allogeneic stem cell transplantation recipients.
Topics: Adolescent; Adult; Antifungal Agents; Female; Hematologic Neoplasms; Humans; Male; Middle Aged; Mycoses; Retrospective Studies; Stem Cell Transplantation; Time Factors; Transplantation, Homologous; Triazoles; Young Adult | 2011 |
Lack of pharmacokinetic drug interaction between oral posaconazole and caspofungin or micafungin.
Topics: Administration, Oral; Adolescent; Adult; Antifungal Agents; Area Under Curve; Caspofungin; Drug Interactions; Echinocandins; Female; Humans; Infusions, Intravenous; Lipopeptides; Male; Micafungin; Triazoles; Young Adult | 2011 |
Exposure-response of posaconazole used for prophylaxis against invasive fungal infections: evaluating the need to adjust doses based on drug concentrations in plasma.
Topics: Antifungal Agents; Antineoplastic Agents; Dose-Response Relationship, Drug; Double-Blind Method; Graft vs Host Disease; Humans; Mycoses; Neutropenia; Stem Cell Transplantation; Treatment Outcome; Triazoles | 2010 |
[Economic evaluation of posaconazole in prophylaxis of invasive fungal infections in Italian neutropenic patients with acute myeloid leukaemia or myelodysplastic syndrome].
Topics: Administration, Oral; Amphotericin B; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Cost-Benefit Analysis; Deoxycholic Acid; Drug Combinations; Drug Costs; Equipment and Supplies; Fluconazole; Follow-Up Studies; Hospital Costs; Humans; Immunocompromised Host; Infusions, Intravenous; Italy; Itraconazole; Leukemia, Myeloid, Acute; Mycoses; Myelodysplastic Syndromes; Neutropenia; Oncology Nursing; Treatment Outcome; Triazoles | 2010 |
Effect of posaconazole on the pharmacokinetics of fosamprenavir and vice versa in healthy volunteers.
Topics: Adolescent; Adult; Anti-HIV Agents; Antifungal Agents; Carbamates; Cross-Over Studies; Drug Interactions; Female; Furans; Healthy Volunteers; Humans; Male; Middle Aged; Organophosphates; Sulfonamides; Triazoles; Young Adult | 2010 |
Relevance of timing for determination of posaconazole plasma concentrations.
Topics: Adult; Aged; Antifungal Agents; Female; Humans; Male; Middle Aged; Triazoles; Young Adult | 2011 |
Posaconazole plasma concentrations in critically ill patients.
Topics: Antifungal Agents; Area Under Curve; Critical Illness; Dose-Response Relationship, Drug; Drug Monitoring; Female; Humans; Intensive Care Units; Intubation, Gastrointestinal; Male; Middle Aged; Triazoles | 2011 |
Determination of posaconazole levels in toenails of adults with onychomycosis following oral treatment with four regimens of posaconazole for 12 or 24 weeks.
Topics: Adolescent; Adult; Aged; Antifungal Agents; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Nails; Onychomycosis; Treatment Outcome; Triazoles; Young Adult | 2011 |
A twice daily posaconazole dosing algorithm for children with chronic granulomatous disease.
Topics: Adolescent; Algorithms; Antibiotic Prophylaxis; Antifungal Agents; Child; Child, Preschool; Female; Granulomatous Disease, Chronic; Humans; Male; Treatment Outcome; Triazoles | 2011 |
A randomized, placebo- and active-controlled, parallel-group, multicentre, investigator-blinded study of four treatment regimens of posaconazole in adults with toenail onychomycosis.
Topics: Administration, Oral; Adolescent; Adult; Aged; Antifungal Agents; Double-Blind Method; Drug Administration Schedule; Female; Foot Dermatoses; Humans; Male; Middle Aged; Naphthalenes; Onychomycosis; Tablets; Terbinafine; Treatment Outcome; Triazoles; Young Adult | 2012 |
Effect of pH and comedication on gastrointestinal absorption of posaconazole: monitoring of intraluminal and plasma drug concentrations.
Topics: Administration, Oral; Adult; Anti-Ulcer Agents; Antifungal Agents; Carbonated Beverages; Cross-Over Studies; Drug Interactions; Esomeprazole; Female; Food-Drug Interactions; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Male; Triazoles; Young Adult | 2011 |
Measurement of posaconazole, itraconazole, and hydroxyitraconazole in plasma/serum by high-performance liquid chromatography with fluorescence detection.
Topics: Adult; Aged; Antifungal Agents; Calibration; Chromatography, High Pressure Liquid; Cohort Studies; Dose-Response Relationship, Drug; Drug Monitoring; Female; Humans; Invasive Pulmonary Aspergillosis; Itraconazole; Limit of Detection; Male; Middle Aged; Neutropenia; Reproducibility of Results; Spectrometry, Fluorescence; Triazoles; Young Adult | 2011 |
Effect of posaconazole on the pharmacokinetics of simvastatin and midazolam in healthy volunteers.
Topics: Administration, Oral; Adolescent; Adult; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Female; Humans; Male; Midazolam; Middle Aged; Simvastatin; Triazoles; Young Adult | 2012 |
Pharmacokinetics of different dosing strategies of oral posaconazole in patients with compromised gastrointestinal function and who are at high risk for invasive fungal infection.
Topics: Administration, Oral; Adult; Aged; Antifungal Agents; Area Under Curve; Biological Availability; Diet, High-Fat; Dietary Supplements; Drug Administration Schedule; Drug Dosage Calculations; Female; Gastrointestinal Tract; Humans; Immunocompromised Host; Intestinal Absorption; Male; Middle Aged; Mycoses; Risk; Triazoles | 2012 |
Impact of benzodiazepines on posaconazole serum concentrations. A population-based pharmacokinetic study on drug interaction.
Topics: Anti-Anxiety Agents; Antifungal Agents; Benzodiazepines; Dose-Response Relationship, Drug; Drug Interactions; Humans; Lorazepam; Male; Retrospective Studies; Serum; Temazepam; Triazoles | 2012 |
A multicenter, open-label study of posaconazole oral suspension in the treatment of invasive fungal infections in patients refractory to or intolerant of first-line therapy.
Topics: Administration, Oral; Adolescent; Adult; Aged; Antifungal Agents; Aspergillus; Candida; Drug Tolerance; Female; Fusarium; Humans; Male; Middle Aged; Mycoses; Salvage Therapy; Triazoles; Young Adult | 2012 |
Single-dose phase I study to evaluate the pharmacokinetics of posaconazole in new tablet and capsule formulations relative to oral suspension.
Topics: Adolescent; Adult; Antifungal Agents; Capsules; Chemistry, Pharmaceutical; Cross-Over Studies; Eating; Fasting; Female; Food-Drug Interactions; Humans; Male; Middle Aged; Suspensions; Tablets; Triazoles; Young Adult | 2012 |
Comparison of posaconazole versus weekly amphotericin B lipid complex for the prevention of invasive fungal infections in hematopoietic stem-cell transplantation.
Topics: Administration, Oral; Adult; Aged; Amphotericin B; Antifungal Agents; Female; Hematopoietic Stem Cell Transplantation; Humans; Infusions, Intravenous; Leukemia; Lipids; Lymphoma; Male; Middle Aged; Mycoses; Prospective Studies; Risk; Tacrolimus; Time Factors; Transplantation, Homologous; Triazoles | 2012 |
A new solid oral tablet formulation of posaconazole: a randomized clinical trial to investigate rising single- and multiple-dose pharmacokinetics and safety in healthy volunteers.
Topics: Administration, Oral; Adult; Antifungal Agents; Female; Healthy Volunteers; Humans; Male; Middle Aged; Placebos; Tablets; Triazoles | 2012 |
Evaluation of the practice of antifungal prophylaxis use in patients with newly diagnosed acute myeloid leukemia: results from the SEIFEM 2010-B registry.
Topics: Aged; Antifungal Agents; Female; Humans; Itraconazole; Leukemia, Myeloid, Acute; Male; Middle Aged; Mycoses; Triazoles | 2012 |
Therapeutic drug monitoring of posaconazole in patients with acute myeloid leukemia or myelodysplastic syndrome.
Topics: Adolescent; Adult; Aged; Antifungal Agents; Biological Availability; Chromatography, High Pressure Liquid; Drug Monitoring; Female; Food-Drug Interactions; Gastrointestinal Diseases; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Leukemia, Myeloid, Acute; Male; Middle Aged; Multivariate Analysis; Myelodysplastic Syndromes; Prospective Studies; Spectrophotometry, Ultraviolet; Tacrolimus; Triazoles; Young Adult | 2012 |
A randomized, phase I, 3-way crossover study to examine the effects of food on the pharmacokinetics of single doses of 400 mg posaconazole oral suspension in healthy male Taiwanese subjects.
Topics: Administration, Oral; Adult; Antifungal Agents; Cross-Over Studies; Dietary Fats; Food-Drug Interactions; Humans; Male; Suspensions; Taiwan; Triazoles; Young Adult | 2013 |
Liquid chromatography-mass spectrometry method for the quantification of posaconazole in human plasma: application to pharmacokinetics following single-dose administration in the fasted state and with a high-fat meal.
Topics: Analysis of Variance; Antifungal Agents; Area Under Curve; Calibration; Chromatography, High Pressure Liquid; Cross-Over Studies; Dietary Fats; Food-Drug Interactions; Humans; Indicators and Reagents; Limit of Detection; Mass Spectrometry; Quality Control; Reproducibility of Results; Triazoles | 2013 |
Posaconazole vs. fluconazole as invasive fungal infection prophylaxis in China: a multicenter, randomized, open-label study.
Topics: Adolescent; Adult; Aged; Antifungal Agents; Female; Fluconazole; Humans; Male; Middle Aged; Mycoses; Prospective Studies; Triazoles | 2013 |
No difference between posaconazole and fluconazole antifungal prophylaxis and mycological diagnostics except costs in patients undergoing AML chemotherapy: a 1-year "real-life" evaluation.
Topics: Adult; Aged; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Clinical Laboratory Techniques; Female; Fluconazole; Fungemia; Germany; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Mycoses; Prospective Studies; Triazoles; Young Adult | 2014 |
Clinical effectiveness of posaconazole versus fluconazole as antifungal prophylaxis in hematology-oncology patients: a retrospective cohort study.
Topics: Adult; Aged; Aged, 80 and over; Cohort Studies; Female; Fluconazole; Hematologic Neoplasms; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Mycoses; Retrospective Studies; Treatment Outcome; Triazoles; United States | 2014 |
Phase 1B study of the pharmacokinetics and safety of posaconazole intravenous solution in patients at risk for invasive fungal disease.
Topics: Adult; Aged; Antifungal Agents; Cohort Studies; Dose-Response Relationship, Drug; Female; Humans; Injections, Intravenous; Male; Middle Aged; Mycoses; Pharmaceutical Solutions; Triazoles | 2014 |
Feasibility and effectiveness of posaconazole prophylaxis in combination with micafungin bridging for patients undergoing allogeneic stem cell transplantation: a 6-yr analysis from the cologne cohort for neutropenic patients.
Topics: Administration, Oral; Adolescent; Adult; Aged; Antifungal Agents; Antineoplastic Agents; Drug Therapy, Combination; Echinocandins; Female; Follow-Up Studies; Hematologic Neoplasms; Hematopoietic Stem Cell Transplantation; Humans; Injections, Intravenous; Lipopeptides; Male; Micafungin; Middle Aged; Mycoses; Neutropenia; Survival Analysis; Transplantation, Homologous; Treatment Outcome; Triazoles | 2014 |
Randomized trial of posaconazole and benznidazole for chronic Chagas' disease.
Topics: Adult; Chagas Disease; Chronic Disease; DNA, Protozoan; Female; Humans; Intention to Treat Analysis; Male; Middle Aged; Nitroimidazoles; Prospective Studies; Transaminases; Treatment Outcome; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
Systemic antifungal treatment after posaconazole prophylaxis: results from the SEIFEM 2010-C survey.
Topics: Adolescent; Adult; Aged; Antifungal Agents; Data Collection; Female; Follow-Up Studies; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Mycoses; Prospective Studies; Treatment Outcome; Triazoles; Young Adult | 2014 |
Phase 1b study of new posaconazole tablet for prevention of invasive fungal infections in high-risk patients with neutropenia.
Topics: Antifungal Agents; Female; Humans; Male; Middle Aged; Mycoses; Neutropenia; Tablets; Triazoles | 2014 |
Pharmacokinetics and safety study of posaconazole intravenous solution administered peripherally to healthy subjects.
Topics: Adolescent; Adult; Aged; Antifungal Agents; Dose-Response Relationship, Drug; Double-Blind Method; Female; Healthy Volunteers; Humans; Infusions, Intravenous; Male; Middle Aged; Triazoles; Young Adult | 2015 |
Effect of a high-fat meal on the pharmacokinetics of 300-milligram posaconazole in a solid oral tablet formulation.
Topics: Administration, Oral; Adolescent; Adult; Aged; Antifungal Agents; Cross-Over Studies; Female; Humans; Male; Middle Aged; Tablets; Triazoles; Young Adult | 2015 |
Posaconazole pharmacokinetics after administration of an intravenous solution, oral suspension, and delayed-release tablet to dogs.
Topics: Administration, Intravenous; Administration, Oral; Animals; Antifungal Agents; Biological Availability; Chromatography, High Pressure Liquid; Cross-Over Studies; Delayed-Action Preparations; Dogs; Female; Half-Life; Male; Suspensions; Tablets; Triazoles | 2015 |
Pharmacokinetics of posaconazole prophylaxis of patients with acute myeloid leukemia.
Topics: Adult; Aged; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Female; Humans; Induction Chemotherapy; Leukemia, Myeloid, Acute; Male; Middle Aged; Mycoses; Prospective Studies; Salvage Therapy; Triazoles | 2015 |
Determination of posaconazole concentration with LC-MS/MS in adult patients with hematologic malignancy.
Topics: Adolescent; Adult; Aged; Antifungal Agents; Chromatography, Liquid; Female; Hematologic Neoplasms; Humans; Male; Middle Aged; Mycoses; Tandem Mass Spectrometry; Triazoles; Young Adult | 2015 |
Supersaturation and Precipitation of Posaconazole Upon Entry in the Upper Small Intestine in Humans.
Topics: Adult; Chemical Precipitation; Cross-Over Studies; Dose-Response Relationship, Drug; Female; Gastric Juice; Healthy Volunteers; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Intestinal Secretions; Intestine, Small; Male; Solubility; Solutions; Triazoles; Young Adult | 2016 |
Phase 3 pharmacokinetics and safety study of a posaconazole tablet formulation in patients at risk for invasive fungal disease.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Antifungal Agents; Chemoprevention; Female; Fungemia; Hematologic Neoplasms; Humans; Immunocompromised Host; Male; Middle Aged; Plasma; Survival Analysis; Tablets; Triazoles; Young Adult | 2016 |
Voriconazole more likely than posaconazole increases plasma exposure to sublingual buprenorphine causing a risk of a clinically important interaction.
Topics: Administration, Sublingual; Adult; Analgesics, Opioid; Antifungal Agents; Buprenorphine; Cross-Over Studies; Cytochrome P-450 Enzyme System; Drug Interactions; Healthy Volunteers; Humans; Male; Pain; Single-Blind Method; Triazoles; Voriconazole; Young Adult | 2016 |
Clinical Drug-Drug Interactions Through Cytochrome P450 3A (CYP3A) for the Selective ALK Inhibitor Alectinib.
Topics: Adult; Anaplastic Lymphoma Kinase; Carbazoles; Carcinoma, Non-Small-Cell Lung; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Female; Humans; Lung Neoplasms; Male; Midazolam; Middle Aged; Piperidines; Receptor Protein-Tyrosine Kinases; Rifampin; Treatment Outcome; Triazoles; Young Adult | 2017 |
Posaconazole Tablet Formulation at 400 Milligrams Daily Achieves Desired Minimum Serum Concentrations in Adult Patients with a Hematologic Malignancy or Stem Cell Transplant.
Topics: Adult; Aged; Antifungal Agents; Delayed-Action Preparations; Dose-Response Relationship, Drug; Female; Hematologic Neoplasms; Hematopoietic Stem Cell Transplantation; Humans; Male; Middle Aged; Mycoses; Retrospective Studies; Tablets; Treatment Outcome; Triazoles | 2016 |
Management of Venetoclax-Posaconazole Interaction in Acute Myeloid Leukemia Patients: Evaluation of Dose Adjustments.
Topics: Administration, Oral; Adult; Antifungal Agents; Bridged Bicyclo Compounds, Heterocyclic; Cytochrome P-450 CYP3A; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Sulfonamides; Triazoles | 2017 |
Benznidazole and Posaconazole in Eliminating Parasites in Asymptomatic T. Cruzi Carriers: The STOP-CHAGAS Trial.
Topics: Administration, Oral; Adult; Chagas Disease; Chronic Disease; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Nitroimidazoles; Prospective Studies; Single-Blind Method; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2017 |
Efficacy, safety and feasibility of antifungal prophylaxis with posaconazole tablet in paediatric patients after haematopoietic stem cell transplantation.
Topics: Administration, Oral; Adolescent; Antifungal Agents; Child; Child, Preschool; Female; Hematologic Neoplasms; Hematopoietic Stem Cell Transplantation; Humans; Immunocompromised Host; Male; Mycoses; Tablets; Triazoles | 2017 |
[Efficacy and Safety of Posaconazoleon for Primary Antifungal Prophylaxis against Invasive Fungal Disease in Patients with Stem Cell Transplantation].
Topics: Antifungal Agents; Hematopoietic Stem Cell Transplantation; Humans; Incidence; Mycoses; Stem Cell Transplantation; Triazoles | 2017 |
Pharmacokinetics and safety results from the Phase 3 randomized, open-label, study of intravenous posaconazole in patients at risk of invasive fungal disease.
Topics: Administration, Intravenous; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Antifungal Agents; Chemoprevention; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Immunocompromised Host; Invasive Fungal Infections; Leukemia, Myeloid, Acute; Male; Middle Aged; Myelodysplastic Syndromes; Triazoles; Young Adult | 2017 |
Pharmacokinetics and Tolerability of Letermovir Coadministered With Azole Antifungals (Posaconazole or Voriconazole) in Healthy Subjects.
Topics: Acetates; Administration, Oral; Adult; Antifungal Agents; Antiviral Agents; Area Under Curve; Drug Combinations; Drug Interactions; Female; Healthy Volunteers; Humans; Middle Aged; Quinazolines; Triazoles; Voriconazole | 2018 |
Micafungin versus posaconazole prophylaxis in acute leukemia or myelodysplastic syndrome: A randomized study.
Topics: Administration, Intravenous; Administration, Oral; Adult; Aged; Antifungal Agents; Chemoprevention; Female; Humans; Incidence; Leukemia; Male; Micafungin; Middle Aged; Mycoses; Myelodysplastic Syndromes; Neutropenia; Survival Analysis; Treatment Failure; Triazoles | 2018 |
Sustained Impairment of Lurasidone Clearance After Discontinuation of Posaconazole: Impact of Obesity, and Implications for Patient Safety.
Topics: Adult; Antifungal Agents; Antipsychotic Agents; Body Mass Index; Cytochrome P-450 CYP3A Inhibitors; Drug Administration Schedule; Drug Interactions; Female; Humans; Lurasidone Hydrochloride; Male; Obesity; Triazoles | 2018 |
Single-Dose Pharmacokinetic Properties and Relative Bioavailability of Different Formulations of Posaconazole Oral Suspension in Healthy Volunteers.
Topics: Administration, Oral; Adult; Area Under Curve; Biological Availability; Cross-Over Studies; Drug Compounding; Female; Healthy Volunteers; Humans; Male; Middle Aged; Particle Size; Suspensions; Therapeutic Equivalency; Triazoles; Young Adult | 2019 |
A non-randomized trial to assess the safety, tolerability, and pharmacokinetics of posaconazole oral suspension in immunocompromised children with neutropenia.
Topics: Administration, Oral; Adolescent; Age Factors; Antifungal Agents; Antineoplastic Agents; Area Under Curve; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Immunocompromised Host; Infant; Invasive Fungal Infections; Male; Neoplasms; Neutropenia; Prospective Studies; Triazoles | 2019 |
Matched-paired analysis of patients treated for invasive mucormycosis: standard treatment versus posaconazole new formulations (MoveOn).
Topics: Adolescent; Adult; Aged; Amphotericin B; Antifungal Agents; Child; Child, Preschool; Drug Compounding; Female; Humans; Infant; Infant, Newborn; Invasive Fungal Infections; Male; Matched-Pair Analysis; Middle Aged; Mucorales; Mucormycosis; Prospective Studies; Registries; Triazoles; Young Adult | 2019 |
Implications for IV posaconazole dosing in the era of obesity.
Topics: Antifungal Agents; Humans; Obesity, Morbid; Prospective Studies; Triazoles | 2020 |
Pharmacokinetics and tolerability of intravenous posaconazole in healthy Chinese volunteers: a randomized, open-label and single-dose study.
Topics: Administration, Intravenous; Adult; Antifungal Agents; Area Under Curve; Asian People; Chromatography, Liquid; Dose-Response Relationship, Drug; Female; Humans; Male; Tandem Mass Spectrometry; Triazoles; Young Adult | 2020 |
Posaconazole versus voriconazole for primary treatment of invasive aspergillosis: a phase 3, randomised, controlled, non-inferiority trial.
Topics: Administration, Intravenous; Administration, Oral; Adolescent; Adult; Antifungal Agents; Double-Blind Method; Female; Humans; Invasive Pulmonary Aspergillosis; Male; Middle Aged; Prospective Studies; Triazoles; Voriconazole; Young Adult | 2021 |
Posaconazole for prevention of invasive pulmonary aspergillosis in critically ill influenza patients (POSA-FLU): a randomised, open-label, proof-of-concept trial.
Topics: Adult; Critical Illness; Humans; Influenza, Human; Intensive Care Units; Invasive Pulmonary Aspergillosis; Triazoles | 2021 |
Proof of Concept in Assignment of Within-Subject Variability During Virtual Bioequivalence Studies: Propagation of Intra-Subject Variation in Gastrointestinal Physiology Using Physiologically Based Pharmacokinetic Modeling.
Topics: Adolescent; Adult; Biological Availability; Cross-Over Studies; Delayed-Action Preparations; Gastrointestinal Tract; Humans; Male; Middle Aged; Models, Biological; Proof of Concept Study; Research Design; Therapeutic Equivalency; Triazoles; Young Adult | 2022 |
Posaconazole bioavailability of the solid oral tablet is reduced during severe intestinal mucositis.
Topics: Administration, Oral; Antifungal Agents; Biological Availability; Humans; Mucositis; Tablets; Triazoles | 2022 |
Pharmacokinetic and Exposure Response Analysis of the Double-Blind Randomized Study of Posaconazole and Voriconazole for Treatment of Invasive Aspergillosis.
Topics: Aspergillosis; Double-Blind Method; Humans; Triazoles; Voriconazole | 2023 |
1170 other study(ies) available for triazoles and posaconazole
| Article | Year |
|---|---|
In vitro and in vivo activities of SCH 56592 against Blastomyces dermatitidis.
Topics: Amphotericin B; Animals; Antifungal Agents; Blastomyces; Blastomycosis; Drug Evaluation, Preclinical; Fluconazole; Lethal Dose 50; Lung Diseases, Fungal; Male; Mice; Microbial Sensitivity Tests; Triazoles | 1996 |
In vitro and in vivo efficacies of the azole SCH56592 against Cryptococcus neoformans.
Topics: Amphotericin B; Animals; Antifungal Agents; Blood; Cryptococcus neoformans; Fluconazole; Humans; Itraconazole; Meningitis, Cryptococcal; Microbial Sensitivity Tests; Rabbits; Triazoles | 1996 |
In vitro studies of activities of the antifungal triazoles SCH56592 and itraconazole against Candida albicans, Cryptococcus neoformans, and other pathogenic yeasts.
Topics: Antifungal Agents; Candida; Hydrogen-Ion Concentration; Itraconazole; Microbial Sensitivity Tests; Reference Standards; Solvents; Temperature; Triazoles | 1997 |
Activity of a new triazole, Sch 56592, compared with those of four other antifungal agents tested against clinical isolates of Candida spp. and Saccharomyces cerevisiae.
Topics: Amphotericin B; Antifungal Agents; Candida; Fluconazole; Flucytosine; Humans; Itraconazole; Microbial Sensitivity Tests; Saccharomyces cerevisiae; Triazoles | 1997 |
In vitro activity of SCH-56592 and comparison with activities of amphotericin B and itraconazole against Aspergillus spp.
Topics: Amphotericin B; Analysis of Variance; Antifungal Agents; Aspergillus; Itraconazole; Microbial Sensitivity Tests; Triazoles | 1997 |
Efficacy of SCH-56592 in a temporarily neutropenic murine model of invasive aspergillosis with an itraconazole-susceptible and an itraconazole-resistant isolate of Aspergillus fumigatus.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Drug Resistance, Microbial; Itraconazole; Mice; Mice, Inbred Strains; Microbial Sensitivity Tests; Neutropenia; Survival Rate; Time Factors; Triazoles | 1997 |
Activity of the triazole SCH 56592 against disseminated murine coccidioidomycosis.
Topics: Amphotericin B; Animals; Antifungal Agents; Coccidioides; Coccidioidomycosis; Drug Evaluation, Preclinical; Female; Itraconazole; Mice; Mice, Inbred Strains; Microbial Sensitivity Tests; Triazoles | 1997 |
Activity of SCH 56592 compared with those of fluconazole and itraconazole against Candida spp.
Topics: Antifungal Agents; Candida; Candidiasis; Fluconazole; Itraconazole; Microbial Sensitivity Tests; Triazoles | 1997 |
Antiproliferative effects and mechanism of action of SCH 56592 against Trypanosoma (Schizotrypanum) cruzi: in vitro and in vivo studies.
Topics: Animals; Antiparasitic Agents; Chagas Disease; Dose-Response Relationship, Drug; Female; Mice; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 1998 |
Comparison of In vitro activities of the new triazole SCH56592 and the echinocandins MK-0991 (L-743,872) and LY303366 against opportunistic filamentous and dimorphic fungi and yeasts.
Topics: Anidulafungin; Anti-Bacterial Agents; Antifungal Agents; Caspofungin; Culture Media; Echinocandins; Fungi; Humans; Lipopeptides; Microbial Sensitivity Tests; Mycoses; Opportunistic Infections; Peptides; Peptides, Cyclic; Structure-Activity Relationship; Triazoles; Yeasts | 1998 |
Detection of Candida dubliniensis in oropharyngeal samples from human immunodeficiency virus-infected patients in North America by primary CHROMagar candida screening and susceptibility testing of isolates.
Topics: AIDS-Related Opportunistic Infections; Amphotericin B; Antifungal Agents; Candida; Candidiasis, Oral; Fluconazole; Genotype; HIV Infections; Humans; Itraconazole; Microbial Sensitivity Tests; Mouth; North America; Pharynx; Phenotype; Pyrimidines; Triazoles; Voriconazole | 1998 |
In vitro activity of a new triazole antifungal agent, Sch 56592, against clinical isolates of filamentous fungi.
Topics: Amphotericin B; Antifungal Agents; Flucytosine; Fungi; Humans; Itraconazole; Microbial Sensitivity Tests; Triazoles | 1998 |
Granulocyte colony-stimulating factor and azole antifungal therapy in murine aspergillosis: role of immune suppression.
Topics: Adrenal Cortex Hormones; Animals; Antifungal Agents; Aspergillosis; Granulocyte Colony-Stimulating Factor; Immunosuppression Therapy; Male; Mice; Mice, Inbred ICR; Triazoles | 1998 |
[Antifungal drugs: the new frontier].
Topics: Anidulafungin; Anti-Bacterial Agents; Antifungal Agents; Candidiasis, Vulvovaginal; Caspofungin; Drug Resistance, Microbial; Echinocandins; Female; Fungi; Humans; Lipopeptides; Male; Mycoses; Peptides; Peptides, Cyclic; Pyrimidines; Research; Triazoles; Trypanocidal Agents; Voriconazole | 1998 |
SCH56592 treatment of murine invasive aspergillosis.
Topics: Amphotericin B; Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Colony Count, Microbial; Lung; Lung Diseases, Fungal; Male; Mice; Mice, Inbred ICR; Triazoles | 1998 |
In vitro susceptibilities of Candida bloodstream isolates to the new triazole antifungal agents BMS-207147, Sch 56592, and voriconazole.
Topics: Antifungal Agents; Candida; Candidiasis; Humans; Microbial Sensitivity Tests; Pyrimidines; Thiazoles; Triazoles; Voriconazole | 1998 |
Comparison of a new triazole antifungal agent, Schering 56592, with itraconazole and amphotericin B for treatment of histoplasmosis in immunocompetent mice.
Topics: Amphotericin B; Animals; Antifungal Agents; Disease Models, Animal; Histoplasma; Histoplasmosis; Immunocompetence; Itraconazole; Mice; Microbial Sensitivity Tests; Triazoles | 1999 |
Comparative study of susceptibilities of germinated and ungerminated conidia of Aspergillus fumigatus to various antifungal agents.
Topics: Amphotericin B; Antifungal Agents; Aspergillus fumigatus; Itraconazole; Kinetics; Microbial Sensitivity Tests; Pyrimidines; Time Factors; Triazoles; Voriconazole | 1999 |
In vitro susceptibilities of Candida dubliniensis isolates tested against the new triazole and echinocandin antifungal agents.
Topics: AIDS-Related Opportunistic Infections; Amphotericin B; Anti-Bacterial Agents; Antifungal Agents; Candida; Candidiasis; Caspofungin; Echinocandins; Fluconazole; Flucytosine; Humans; Itraconazole; Lipopeptides; Microbial Sensitivity Tests; Peptides; Peptides, Cyclic; Pyrimidines; Thiazoles; Triazoles; Voriconazole | 1999 |
Treatment of murine fusariosis with SCH 56592.
Topics: Animals; Antifungal Agents; Colony Count, Microbial; Fusarium; Kidney; Male; Mice; Mycoses; Triazoles | 1999 |
SCH 56592.
Topics: Animals; Antifungal Agents; Candidiasis; Chagas Disease; Drugs, Investigational; Fungi; Humans; Mice; Mycoses; Parasitic Diseases; Triazoles | 1999 |
Efficacy of the triazole SCH 56592 against Leishmania amazonensis and Leishmania donovani in experimental murine cutaneous and visceral leishmaniases.
Topics: Amphotericin B; Animals; Fluconazole; Leishmania donovani; Leishmaniasis, Cutaneous; Leishmaniasis, Visceral; Liver; Lymph Nodes; Male; Mice; Mice, Inbred BALB C; Spleen; Time Factors; Triazoles; Trypanocidal Agents | 1999 |
Activities of the triazole derivative SCH 56592 (posaconazole) against drug-resistant strains of the protozoan parasite Trypanosoma (Schizotrypanum) cruzi in immunocompetent and immunosuppressed murine hosts.
Topics: Acute Disease; Animals; Chagas Disease; Chronic Disease; Drug Resistance; Female; Immunocompetence; Immunosuppression Therapy; Mice; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2000 |
In vitro activities of the new antifungal triazole SCH 56592 against common and emerging yeast pathogens.
Topics: Antifungal Agents; Humans; Microbial Sensitivity Tests; Triazoles; Yeasts | 2000 |
Pharmacokinetics of SCH 56592, a new azole broad-spectrum antifungal agent, in mice, rats, rabbits, dogs, and cynomolgus monkeys.
Topics: Animals; Antifungal Agents; Area Under Curve; Biological Availability; Dogs; Dose-Response Relationship, Drug; Food-Drug Interactions; Macaca fascicularis; Male; Mice; Rabbits; Rats; Triazoles | 2000 |
Efficacy of SCH56592 in a rabbit model of invasive aspergillosis.
Topics: Amphotericin B; Animals; Antifungal Agents; Aspergillosis; Aspergillus; Colony Count, Microbial; Disease Models, Animal; Female; Immunosuppression Therapy; Itraconazole; Microbial Sensitivity Tests; Rabbits; Triazoles | 2000 |
SCH 56592, amphotericin B, or itraconazole therapy of experimental murine cerebral phaeohyphomycosis due to Ramichloridium obovoideum ("Ramichloridium mackenziei").
Topics: Amphotericin B; Animals; Antifungal Agents; Ascomycota; Central Nervous System Fungal Infections; Disease Models, Animal; Female; Itraconazole; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Mycoses; Triazoles | 2000 |
High-performance liquid chromatographic analysis of the anti-fungal agent SCH 56592 in dog serum.
Topics: Animals; Antifungal Agents; Chemical Precipitation; Chromatography, High Pressure Liquid; Dogs; Drug Stability; Freezing; Linear Models; Methanol; Microchemistry; Quality Control; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Triazoles | 2000 |
In vitro susceptibility of environmental Cryptococcus neoformans variety neoformans isolates from Turkey to six antifungal agents, including SCH56592 and voriconazole.
Topics: Animals; Antifungal Agents; Columbidae; Cryptococcus neoformans; Environmental Microbiology; Feces; Microbial Sensitivity Tests; Pyrimidines; Triazoles; Turkey; Voriconazole | 2000 |
In vitro and in vivo activities of SCH 56592 (posaconazole), a new triazole antifungal agent, against Aspergillus and Candida.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus; Candida; Candidiasis; Disease Models, Animal; Lung Diseases, Fungal; Male; Mice; Microbial Sensitivity Tests; Treatment Outcome; Triazoles | 2000 |
A comparative study of the in vitro susceptibilities of clinical and laboratory-selected resistant isolates of Aspergillus spp. to amphotericin B, itraconazole, voriconazole and posaconazole (SCH 56592).
Topics: Amphotericin B; Antifungal Agents; Aspergillosis; Aspergillus; Itraconazole; Microbial Sensitivity Tests; Mutation; Pyrimidines; Triazoles; Voriconazole | 2000 |
Interactions between triazoles and amphotericin B against Cryptococcus neoformans.
Topics: Amphotericin B; Animals; Antifungal Agents; Cryptococcosis; Cryptococcus neoformans; Disease Models, Animal; Drug Therapy, Combination; Fluconazole; Humans; Itraconazole; Male; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Triazoles | 2000 |
Comparison of a new triazole, posaconazole, with itraconazole and amphotericin B for treatment of histoplasmosis following pulmonary challenge in immunocompromised mice.
Topics: Amphotericin B; Animals; Antifungal Agents; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Histoplasma; Histoplasmosis; Immunocompromised Host; Immunosuppression Therapy; Itraconazole; Lung; Mice; Mice, Inbred Strains; Spleen; Survival Analysis; Time Factors; Triazoles | 2000 |
Effect of solubilizing excipients on permeation of poorly water-soluble compounds across Caco-2 cell monolayers.
Topics: Alkaloids; Biological Transport; Caco-2 Cells; Cell Membrane Permeability; Cimetidine; Diltiazem; Excipients; Furans; Humans; Hydrogen-Ion Concentration; Imidazoles; Intestinal Absorption; Naphthalenes; Phenytoin; Piperidines; Poloxamer; Polyethylene Glycols; Povidone; Propranolol; Solubility; Triazoles | 2000 |
Antifungal activity and pharmacokinetics of posaconazole (SCH 56592) in treatment and prevention of experimental invasive pulmonary aspergillosis: correlation with galactomannan antigenemia.
Topics: Animals; Antibiotic Prophylaxis; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Disease Models, Animal; Female; Galactose; Itraconazole; Lung Diseases, Fungal; Mannans; Neutropenia; Rabbits; Treatment Outcome; Triazoles | 2001 |
Interactions of posaconazole and flucytosine against Cryptococcus neoformans.
Topics: Animals; Antifungal Agents; Colony Count, Microbial; Cryptococcosis; Cryptococcus neoformans; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Flucytosine; Male; Meningitis, Cryptococcal; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Triazoles | 2001 |
Isolation and in vitro susceptibility to amphotericin B, itraconazole and posaconazole of voriconazole-resistant laboratory isolates of Aspergillus fumigatus.
Topics: Amphotericin B; Antifungal Agents; Aspergillus fumigatus; Drug Resistance, Microbial; Humans; Itraconazole; Microbial Sensitivity Tests; Pyrimidines; Triazoles; Voriconazole | 2001 |
Structural characterization of the oxidative degradation products of an antifungal agent SCH 56592 by LC-NMR and LC-MS.
Topics: Antifungal Agents; Chromatography, High Pressure Liquid; Magnetic Resonance Spectroscopy; Mass Spectrometry; Oxidation-Reduction; Triazoles | 2001 |
In vitro activities of four novel triazoles against Scedosporium spp.
Topics: Antifungal Agents; Humans; Microbial Sensitivity Tests; Pyrimidines; Quinazolines; Scedosporium; Thiazoles; Triazoles; Voriconazole | 2001 |
In vitro antifungal activity of posaconazole against various pathogenic fungi.
Topics: Antifungal Agents; Aspergillus fumigatus; Candida albicans; Fungi; Humans; Microbial Sensitivity Tests; Mycoses; Triazoles | 2001 |
In vitro activities of posaconazole (Sch 56592) compared with those of itraconazole and fluconazole against 3,685 clinical isolates of Candida spp. and Cryptococcus neoformans.
Topics: Antifungal Agents; Candida; Cryptococcus neoformans; Fluconazole; Humans; Itraconazole; Microbial Sensitivity Tests; Triazoles | 2001 |
Simultaneous high-performance liquid chromatographic determination of SCH 59884 (phosphate ester prodrug of SCH 56592), SCH 207962 and SCH 56592 in dog plasma.
Topics: Animals; Antifungal Agents; Area Under Curve; Chromatography, High Pressure Liquid; Dogs; Drug Stability; Injections, Intravenous; Molecular Structure; Organophosphates; Prodrugs; Reference Standards; Triazoles | 2002 |
Evaluation of Etest method for determining posaconazole MICs for 314 clinical isolates of Candida species.
Topics: Antifungal Agents; Candida; Candidiasis; Humans; Microbial Sensitivity Tests; Triazoles | 2001 |
In vitro activity of posaconazole against clinical isolates of dermatophytes.
Topics: Antifungal Agents; Arthrodermataceae; Dermatomycoses; Humans; Itraconazole; Microbial Sensitivity Tests; Triazoles | 2001 |
Activity of the new antifungal triazole, posaconazole, against Cryptococcus neoformans.
Topics: Animals; Antifungal Agents; Cryptococcosis; Cryptococcus neoformans; Humans; Male; Mice; Microbial Sensitivity Tests; Triazoles | 2001 |
Aspergillus: rising frequency of clinical isolation and continued susceptibility to antifungal agents, 1994-1999.
Topics: Amphotericin B; Antifungal Agents; Aspergillosis; Aspergillus; Aspergillus flavus; Aspergillus fumigatus; Aspergillus niger; Humans; Itraconazole; Pyrimidines; Triazoles; Voriconazole | 2001 |
Azole cross-resistance in Aspergillus fumigatus.
Topics: Antifungal Agents; Aspergillus fumigatus; Drug Resistance, Microbial; Drug Resistance, Multiple; Itraconazole; Microbial Sensitivity Tests; Pyrimidines; Triazoles; Voriconazole | 2002 |
Genotyping and antifungal susceptibility of human subgingival Candida albicans isolates.
Topics: Adult; Amphotericin B; Antifungal Agents; Candida albicans; Dental Plaque; DNA, Fungal; Drug Resistance, Fungal; Female; Fluconazole; Genetic Heterogeneity; HIV Infections; Humans; Itraconazole; Karyotyping; Male; Microbial Sensitivity Tests; Mycological Typing Techniques; Triazoles | 2002 |
Antifungal activities of posaconazole, ravuconazole, and voriconazole compared to those of itraconazole and amphotericin B against 239 clinical isolates of Aspergillus spp. and other filamentous fungi: report from SENTRY Antimicrobial Surveillance Program
Topics: Amphotericin B; Antifungal Agents; Aspergillosis; Aspergillus; Canada; Fungi; Humans; Microbial Sensitivity Tests; Mycoses; Pyrimidines; Quality Control; Thiazoles; Triazoles; United States; Voriconazole | 2002 |
Mechanism of azole antifungal activity as determined by liquid chromatographic/mass spectrometric monitoring of ergosterol biosynthesis.
Topics: Antifungal Agents; Azoles; Candida albicans; Chromatography, High Pressure Liquid; Ergosterol; Lanosterol; Spectrometry, Mass, Electrospray Ionization; Sterols; Triazoles | 2002 |
In vitro and in vivo activities of posaconazole against Coccidioides immitis.
Topics: Animals; Antifungal Agents; Coccidioides; Coccidioidomycosis; Disease Models, Animal; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Triazoles | 2002 |
Clinical evaluation of a frozen commercially prepared microdilution panel for antifungal susceptibility testing of seven antifungal agents, including the new triazoles posaconazole, ravuconazole, and voriconazole.
Topics: Antifungal Agents; Candida; Freezing; Humans; Microbial Sensitivity Tests; Pyrimidines; Thiazoles; Triazoles; Voriconazole | 2002 |
Treatment of Scedosporium apiospermum brain abscesses with posaconazole.
Topics: Adult; Antifungal Agents; Brain Abscess; Humans; Male; Mycetoma; Scedosporium; Treatment Outcome; Triazoles | 2002 |
E-test method for testing susceptibilities of Aspergillus spp. to the new triazoles voriconazole and posaconazole and to established antifungal agents: comparison with NCCLS broth microdilution method.
Topics: Antifungal Agents; Aspergillus; Humans; Microbial Sensitivity Tests; Pyrimidines; Reproducibility of Results; Triazoles; Voriconazole | 2002 |
Antifungal triazoles and polymorphonuclear leukocytes synergize to cause increased hyphal damage to Scedosporium prolificans and Scedosporium apiospermum.
Topics: Adult; Antifungal Agents; Humans; Hyphae; Itraconazole; Neutrophils; Pyrimidines; Scedosporium; Triazoles; Voriconazole | 2002 |
In vivo activity of posaconazole against Mucor spp. in an immunosuppressed-mouse model.
Topics: Animals; Antifungal Agents; Immunocompromised Host; Male; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Mucor; Mucormycosis; Triazoles | 2002 |
Ocular and systemic posaconazole(SCH-56592) treatment of invasive Fusarium solani keratitis and endophthalmitis.
Topics: Administration, Oral; Administration, Topical; Adult; Antifungal Agents; Endophthalmitis; Eye Infections, Fungal; Female; Fusarium; Humans; Keratitis; Triazoles | 2002 |
In vitro activity of three new triazoles and one echinocandin against Candida bloodstream isolates from cancer patients.
Topics: Antifungal Agents; Blood; Candida; Candidiasis; Echinocandins; Humans; In Vitro Techniques; Lipopeptides; Lipoproteins; Micafungin; Microbial Sensitivity Tests; Neoplasms; Peptides, Cyclic; Pyrimidines; Thiazoles; Triazoles; Voriconazole | 2002 |
Effect of medium composition on static and cidal activity of amphotericin B, itraconazole, voriconazole, posaconazole and terbinafine against Aspergillus fumigatus: a multicenter study.
Topics: Amphotericin B; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Culture Media; France; Humans; Itraconazole; Laboratories; Microbial Sensitivity Tests; Naphthalenes; Observer Variation; Pyrimidines; Terbinafine; Triazoles; Voriconazole | 2002 |
In vitro activities of investigational triazoles against Fusarium species: effects of inoculum size and incubation time on broth microdilution susceptibility test results.
Topics: Antifungal Agents; Colony Count, Microbial; Culture Media; Fusarium; Humans; Microbial Sensitivity Tests; Pyrimidines; Triazoles; Voriconazole | 2002 |
In vitro susceptibilities of cerebrospinal fluid isolates of Cryptococcus neoformans collected during a ten-year period against fluconazole, voriconazole and posaconazole (SCH56592).
Topics: Antifungal Agents; Cerebrospinal Fluid; Cryptococcosis; Cryptococcus neoformans; Drug Resistance, Microbial; Fluconazole; Humans; In Vitro Techniques; Microbial Sensitivity Tests; Pyrimidines; Triazoles; Voriconazole | 2002 |
In vitro activities of voriconazole, posaconazole, and four licensed systemic antifungal agents against Candida species infrequently isolated from blood.
Topics: Antifungal Agents; Blood; Candida; Humans; Microbial Sensitivity Tests; Pyrimidines; Triazoles; Voriconazole | 2003 |
Mutations in Aspergillus fumigatus resulting in reduced susceptibility to posaconazole appear to be restricted to a single amino acid in the cytochrome P450 14alpha-demethylase.
Topics: Antifungal Agents; Aspergillus fumigatus; Cytochrome P-450 Enzyme System; Microbial Sensitivity Tests; Oxidoreductases; Point Mutation; Sterol 14-Demethylase; Triazoles | 2003 |
[In vitro activity of posaconazole against yeasts isolated in blood cultures].
Topics: Bacteriological Techniques; Blood; Humans; Triazoles; Yeasts | 2002 |
Use of high-performance liquid chromatographic and microbiological analyses for evaluating the presence or absence of active metabolites of the antifungal posaconazole in human plasma.
Topics: Antifungal Agents; Chromatography, High Pressure Liquid; Humans; Quality Control; Reproducibility of Results; Sensitivity and Specificity; Triazoles | 2003 |
Activity of posaconazole against Pseudallescheria boydii: in vitro and in vivo assays.
Topics: Animals; Antifungal Agents; Drug Resistance, Fungal; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Mycetoma; Pseudallescheria; Triazoles | 2003 |
In vitro susceptibility testing of filamentous fungi: comparison of Etest and reference M38-A microdilution methods for determining posaconazole MICs.
Topics: Antifungal Agents; Culture Media; Drug Resistance, Fungal; Fungi; Humans; Microbial Sensitivity Tests; Microbiological Techniques; Sensitivity and Specificity; Triazoles | 2003 |
Mucormycosis (zygomycosis) in a heart-kidney transplant recipient: recovery after posaconazole therapy.
Topics: Antifungal Agents; Diabetes Complications; Heart Transplantation; Humans; Immunosuppression Therapy; Kidney Transplantation; Male; Middle Aged; Mucormycosis; Postoperative Complications; Triazoles | 2003 |
Posaconazole: SCH 56592.
Topics: Administration, Oral; Antifungal Agents; Clinical Trials as Topic; Cytochrome P-450 Enzyme Inhibitors; Humans; Mycoses; Opportunistic Infections; Oxidoreductases; Sterol 14-Demethylase; Treatment Outcome; Triazoles | 2003 |
Activities of caspofungin, itraconazole, posaconazole, ravuconazole, voriconazole, and amphotericin B against 448 recent clinical isolates of filamentous fungi.
Topics: Amphotericin B; Anti-Bacterial Agents; Aspergillus; Caspofungin; Echinocandins; Fungi; Humans; Itraconazole; Lipopeptides; Microbial Sensitivity Tests; Mycoses; Penicillium; Peptides; Peptides, Cyclic; Pyrimidines; Thiazoles; Triazoles; Voriconazole | 2003 |
[In vitro activity of fluconazole, voriconazole and posaconazole against Candida spp].
Topics: Antifungal Agents; Candida; Candidiasis; Drug Resistance, Fungal; Fluconazole; Humans; Microbial Sensitivity Tests; Pyrimidines; Species Specificity; Triazoles; Voriconazole | 2003 |
Activity of posaconazole in treatment of experimental disseminated zygomycosis.
Topics: Absidia; Amphotericin B; Animals; Antifungal Agents; Brain; Female; Itraconazole; Kidney; Mice; Microbial Sensitivity Tests; Rhizopus; Triazoles; Zygomycosis | 2003 |
Changes in susceptibility to posaconazole in clinical isolates of Candida albicans.
Topics: AIDS-Related Opportunistic Infections; Antifungal Agents; Candida albicans; Candidiasis, Oral; Drug Resistance, Fungal; Genes, Viral; HIV Infections; Humans; Microbial Sensitivity Tests; Mutation; Triazoles | 2004 |
Pharmacodynamics of a new triazole, posaconazole, in a murine model of disseminated candidiasis.
Topics: Animals; Antifungal Agents; Area Under Curve; Candida albicans; Candidiasis; Colony Count, Microbial; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Neutropenia; Triazoles | 2004 |
Case study: posaconazole treatment of disseminated phaeohyphomycosis due to Exophiala spinifera.
Topics: Adult; Antifungal Agents; Drug Therapy, Combination; Exophiala; Female; Flucytosine; Humans; Itraconazole; Mycoses; Pregnancy; Pregnancy Complications, Infectious; Triazoles | 2004 |
Three-dimensional models of wild-type and mutated forms of cytochrome P450 14alpha-sterol demethylases from Aspergillus fumigatus and Candida albicans provide insights into posaconazole binding.
Topics: Amino Acid Sequence; Antifungal Agents; Aspergillus fumigatus; Azoles; Binding Sites; Candida albicans; Crystallography, X-Ray; Cytochrome P-450 Enzyme System; Drug Resistance, Fungal; Fungal Proteins; Ligands; Membrane Proteins; Models, Molecular; Molecular Sequence Data; Mutation; Protein Binding; Triazoles | 2004 |
Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of posaconazole (Noxafil).
Topics: Antifungal Agents; Chromatography, Liquid; Coumarins; Glucuronides; Glucuronosyltransferase; Humans; In Vitro Techniques; Kinetics; Mass Spectrometry; Microsomes, Liver; Recombinant Proteins; Triazoles; Trifluoperazine | 2004 |
Activity of posaconazole combined with amphotericin B against Aspergillus flavus infection in mice: comparative studies in two laboratories.
Topics: Amphotericin B; Animals; Antifungal Agents; Aspergillosis; Aspergillus flavus; Colony Count, Microbial; Lung; Mice; Survival Analysis; Triazoles | 2004 |
Aspergillus fumigatus empyema, arthritis, and calcaneal osteomyelitis in a lung transplant patient successfully treated with posaconazole.
Topics: Antifungal Agents; Arthritis, Infectious; Aspergillosis; Aspergillus fumigatus; Empyema; Humans; Lung Transplantation; Male; Middle Aged; Pulmonary Disease, Chronic Obstructive; Time Factors; Treatment Outcome; Triazoles | 2004 |
In vitro activities of voriconazole, posaconazole, and fluconazole against 4,169 clinical isolates of Candida spp. and Cryptococcus neoformans collected during 2001 and 2002 in the ARTEMIS global antifungal surveillance program.
Topics: Candida; Cryptococcus neoformans; Drug Resistance, Fungal; Fluconazole; Global Health; Humans; Microbial Sensitivity Tests; Molecular Epidemiology; Multicenter Studies as Topic; Probability; Pyrimidines; Sensitivity and Specificity; Triazoles; Voriconazole | 2004 |
[Fulminant invasive fungal sinusitis in immunosuppressed hosts -- pathognomic presentation in MRI].
Topics: Adult; Amphotericin B; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Ethmoid Sinusitis; Humans; Immunocompromised Host; Magnetic Resonance Imaging; Male; Mucor; Mucormycosis; Triazoles | 2004 |
Application of real-time quantitative PCR to molecular analysis of Candida albicans strains exhibiting reduced susceptibility to azoles.
Topics: Actins; Antifungal Agents; Azoles; Candida albicans; Candidiasis, Oral; Cloning, Molecular; Computer Systems; DNA-Binding Proteins; DNA, Fungal; Drug Resistance, Fungal; Fungal Proteins; Gene Expression Regulation, Fungal; Microbial Sensitivity Tests; Mutation; Oropharynx; Proton-Translocating ATPases; Reverse Transcriptase Polymerase Chain Reaction; Saccharomyces cerevisiae Proteins; Species Specificity; Transcription, Genetic; Triazoles | 2004 |
Posaconazole therapy of disseminated phaeohyphomycosis in a murine model.
Topics: Animals; Antifungal Agents; Brain; Colony Count, Microbial; Exophiala; Immunocompromised Host; Mice; Mice, Inbred BALB C; Mice, Nude; Mycoses; Survival Analysis; Triazoles | 2004 |
Alternatives to amphotericin B for Candida rugosa infection.
Topics: Amphotericin B; Animals; Antifungal Agents; Candidiasis; Colony Count, Microbial; Fluconazole; Kidney; Male; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Neutropenia; Organ Size; Pyrimidines; Spleen; Survival Analysis; Triazoles; Voriconazole | 2004 |
Effect of granulocyte colony-stimulating factor combination therapy on efficacy of posaconazole (SCH56592) in an inhalation model of murine pulmonary aspergillosis.
Topics: Animals; Antifungal Agents; Aspergillosis, Allergic Bronchopulmonary; Drug Therapy, Combination; Granulocyte Colony-Stimulating Factor; Lung; Male; Mice; Survival Analysis; Triazoles | 2004 |
Challenges in designing animal studies to detect antagonism of polyene activity.
Topics: Amphotericin B; Animals; Antifungal Agents; Aspergillosis; Polyenes; Research Design; Triazoles | 2004 |
Use of fatty acid RPMI 1640 media for testing susceptibilities of eight Malassezia species to the new triazole posaconazole and to six established antifungal agents by a modified NCCLS M27-A2 microdilution method and Etest.
Topics: Antifungal Agents; Culture Media; Fatty Acids; Humans; Malassezia; Microbial Sensitivity Tests; Mycoses; Triazoles | 2004 |
Posaconazole and amphotericin B combination therapy against Cryptococcus neoformans infection.
Topics: AIDS-Related Opportunistic Infections; Amphotericin B; Animals; Antifungal Agents; Brain; Colony Count, Microbial; Cryptococcosis; Cryptococcus neoformans; Disease Progression; Drug Therapy, Combination; Humans; Lung; Male; Mice; Survival Analysis; Triazoles | 2004 |
Zygomycosis in neutropenic patients with past Aspergillus infection: a role for posaconazole?
Topics: Antifungal Agents; Aspergillosis; Humans; Neutropenia; Triazoles; Zygomycosis | 2004 |
Aspergillus terreus: an emerging amphotericin B-resistant opportunistic mold in patients with hematologic malignancies.
Topics: Adult; Aged; Amphotericin B; Aspergillosis; Aspergillus; Aspergillus fumigatus; Cross Infection; Drug Resistance, Fungal; Female; Humans; Leukemia; Male; Middle Aged; Neutropenia; Opportunistic Infections; Retrospective Studies; Risk Factors; Triazoles | 2004 |
Posaconazole is a potent inhibitor of sterol 14alpha-demethylation in yeasts and molds.
Topics: Antifungal Agents; Aspergillus flavus; Aspergillus fumigatus; Azoles; Candida glabrata; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ergosterol; Gas Chromatography-Mass Spectrometry; Microbial Sensitivity Tests; Oxidoreductases; Sterol 14-Demethylase; Triazoles | 2004 |
Antifungal activities of posaconazole and granulocyte-macrophage colony-stimulating factor ex vivo and in mice with disseminated infection due to Scedosporium prolificans.
Topics: Animals; Antifungal Agents; Brain; Drug Resistance, Fungal; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Kidney; Liver; Male; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Mycetoma; Organ Culture Techniques; Scedosporium; Survival Analysis; Triazoles | 2004 |
Efficacy of posaconazole in a murine model of central nervous system aspergillosis.
Topics: Amphotericin B; Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Central Nervous System Fungal Infections; Male; Mice; Survival; Survival Analysis; Triazoles | 2004 |
Clinical evaluation of the Sensititre YeastOne colorimetric antifungal plate for antifungal susceptibility testing of the new triazoles voriconazole, posaconazole, and ravuconazole.
Topics: Antifungal Agents; Candida; Candidiasis; Humans; Microbial Sensitivity Tests; Pyrimidines; Reagent Kits, Diagnostic; Thiazoles; Triazoles; Voriconazole | 2004 |
Posaconazole therapy for severe abdominal candidiasis: a case report.
Topics: Abdomen; Aged; Antifungal Agents; Candidiasis; Cysts; Female; Humans; Liver Diseases; Postoperative Complications; Severity of Illness Index; Triazoles | 2004 |
Successful treatment of Fusarium proliferatum pneumonia with posaconazole in a lung transplant recipient.
Topics: Antifungal Agents; Fusarium; Humans; Lung Diseases, Fungal; Lung Transplantation; Male; Middle Aged; Opportunistic Infections; Triazoles | 2004 |
Interaction between posaconazole and amphotericin B in concomitant treatment against Candida albicans in vivo.
Topics: Amphotericin B; Animals; Antifungal Agents; Candida albicans; Candidiasis; Drug Interactions; Male; Mice; Survival Analysis; Triazoles | 2005 |
Detection of Aspergillus fumigatus and a mutation that confers reduced susceptibility to itraconazole and posaconazole by real-time PCR and pyrosequencing.
Topics: Antifungal Agents; Aspergillus fumigatus; Base Sequence; Cytochrome P-450 Enzyme System; DNA, Fungal; Drug Resistance, Fungal; Fungal Proteins; Humans; Itraconazole; Microbial Sensitivity Tests; Molecular Sequence Data; Mutation; Polymerase Chain Reaction; Sequence Analysis, DNA; Triazoles | 2005 |
Antifungal activity of posaconazole compared with fluconazole and amphotericin B against yeasts from oropharyngeal candidiasis and other infections.
Topics: Amphotericin B; Antifungal Agents; Candida; Candidiasis, Oral; Fluconazole; Humans; Microbial Sensitivity Tests; Triazoles | 2005 |
In vitro activities of posaconazole, ravuconazole, terbinafine, itraconazole and fluconazole against dermatophyte, yeast and non-dermatophyte species.
Topics: Antifungal Agents; Arthrodermataceae; Fluconazole; Fungi; Humans; Itraconazole; Microbial Sensitivity Tests; Mycoses; Naphthalenes; Terbinafine; Thiazoles; Triazoles; Yeasts | 2005 |
Effect of media composition and in vitro activity of posaconazole, caspofungin and voriconazole against zygomycetes.
Topics: Absidia; Antifungal Agents; Caspofungin; Culture Media; Cunninghamella; Echinocandins; Lipopeptides; Microbial Sensitivity Tests; Mucor; Mucorales; Peptides, Cyclic; Pyrimidines; Rhizopus; Triazoles; Voriconazole | 2005 |
Refractory coccidioidomycosis treated with posaconazole.
Topics: Adolescent; Adult; Antifungal Agents; Coccidioidomycosis; Dermatomycoses; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Skin; Triazoles | 2005 |
In vitro activities of new and established triazoles against opportunistic filamentous and dimorphic fungi.
Topics: Antifungal Agents; Fungi; Humans; Microbial Sensitivity Tests; Mycoses; Pyrimidines; Species Specificity; Thiazoles; Triazoles; Voriconazole | 2005 |
In vitro interaction of posaconazole and caspofungin against clinical isolates of Candida glabrata.
Topics: Antifungal Agents; Candida glabrata; Candidiasis, Oral; Caspofungin; Drug Resistance, Fungal; Drug Synergism; Echinocandins; Fluconazole; Humans; Lipopeptides; Microbial Sensitivity Tests; Peptides, Cyclic; Triazoles | 2005 |
International and multicenter comparison of EUCAST and CLSI M27-A2 broth microdilution methods for testing susceptibilities of Candida spp. to fluconazole, itraconazole, posaconazole, and voriconazole.
Topics: Antifungal Agents; Candida; Fluconazole; Itraconazole; Microbial Sensitivity Tests; Pyrimidines; Reproducibility of Results; Triazoles; Voriconazole | 2005 |
Lung infection due to opportunistic fungus, Phialemonium obovatum, in a bone marrow transplant recipient: an emerging infection with fungemia and Crohn disease-like involvement of the gastrointestinal tract.
Topics: Amphotericin B; Antifungal Agents; Ascomycota; Bone Marrow Transplantation; Drug Resistance, Fungal; Fungemia; Gastrointestinal Diseases; Graft vs Host Disease; Granuloma; Humans; Immunocompromised Host; Itraconazole; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lung Diseases, Fungal; Male; Middle Aged; Opportunistic Infections; Pyrimidines; Triazoles; Voriconazole | 2005 |
Pulmonary mucormycosis (zygomycosis) in a lung transplant recipient: recovery after posaconazole therapy.
Topics: Absidia; Antifungal Agents; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Bronchoscopy; Fatal Outcome; Female; Follow-Up Studies; Humans; Lung Diseases, Fungal; Lung Transplantation; Middle Aged; Mucormycosis; Pulmonary Fibrosis; Tomography, X-Ray Computed; Triazoles | 2005 |
Successful treatment of pulmonary zygomycosis with posaconazole in a recipient of a haploidentical donor stem cell transplant.
Topics: Adolescent; Antifungal Agents; Haplotypes; Histocompatibility Testing; Humans; Leukemia, Monocytic, Acute; Lung Diseases, Fungal; Male; Peripheral Blood Stem Cell Transplantation; Triazoles; Zygomycosis | 2006 |
Comparison of visual 24-hour and spectrophotometric 48-hour MICs to CLSI reference microdilution MICs of fluconazole, itraconazole, posaconazole, and voriconazole for Candida spp.: a collaborative study.
Topics: Antifungal Agents; Candida; Candidiasis; Drug Resistance, Fungal; Fluconazole; Humans; Itraconazole; Microbial Sensitivity Tests; Pyrimidines; Reference Standards; Reproducibility of Results; Spectrophotometry; Triazoles; Voriconazole | 2005 |
What does "culture of life" mean for an undocumented immigrant?
Topics: Adult; Antifungal Agents; Clinical Trials as Topic; Coccidioidomycosis; Emigration and Immigration; Ethics, Medical; HIV Infections; Humans; Male; Mexico; Transients and Migrants; Triazoles; United States | 2005 |
Quality control and reference guidelines for CLSI broth microdilution susceptibility method (M 38-A document) for amphotericin B, itraconazole, posaconazole, and voriconazole.
Topics: Amphotericin B; Antifungal Agents; Drug Resistance, Fungal; Fungi; Humans; Itraconazole; Microbial Sensitivity Tests; Paecilomyces; Pyrimidines; Quality Control; Triazoles; Voriconazole | 2005 |
Advances in antifungal therapy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anidulafungin; Animals; Antifungal Agents; Caspofungin; Child; Child, Preschool; Clinical Trials as Topic; Echinocandins; Fungal Proteins; Humans; Infant; Infant, Newborn; Lipopeptides; Lipoproteins; Micafungin; Middle Aged; Mycoses; Peptides, Cyclic; Pyrimidines; Thiazoles; Treatment Outcome; Triazoles; Voriconazole | 2005 |
Absidia posttraumatic infection: successful treatment with posaconazole.
Topics: Absidia; Antifungal Agents; Facial Injuries; Humans; Male; Mandibular Injuries; Middle Aged; Mucormycosis; Orbital Fractures; Treatment Outcome; Triazoles | 2005 |
A case of disseminated histoplasmosis successfully treated with the investigational drug posaconazole.
Topics: Aged; Antifungal Agents; Drugs, Investigational; Histoplasma; Histoplasmosis; Humans; Male; Treatment Outcome; Triazoles | 2005 |
Treatment of zygomycosis with posaconazole in a patient with acute myeloid leukemia.
Topics: Amphotericin B; Antifungal Agents; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Rhizopus; Triazoles; Zygomycosis | 2005 |
Hydroxylated analogues of the orally active broad spectrum antifungal, Sch 51048 (1), and the discovery of posaconazole [Sch 56592; 2 or (S,S)-5].
Topics: Alcohols; Animals; Antifungal Agents; Aspergillosis; Candidiasis; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Drug Design; Drug Evaluation, Preclinical; Haplorhini; Humans; Immunosuppressive Agents; Mice; Models, Chemical; Time Factors; Triazoles | 2006 |
Posaconazole therapy for systemic coccidioidomycosis in a chimpanzee (Pan troglodytes): a case report.
Topics: Animals; Antibodies, Fungal; Antifungal Agents; Ape Diseases; Blood; Central Nervous System Fungal Infections; Cerebrospinal Fluid; Coccidioides; Coccidioidomycosis; Fluconazole; Laparoscopy; Male; Pan troglodytes; Triazoles | 2005 |
Mucormycoses in patients with hematologic malignancies: an emerging fungal infection.
Topics: Adult; Aged; Amphotericin B; Antifungal Agents; Antineoplastic Agents; Communicable Diseases, Emerging; Dermatomycoses; Disease Susceptibility; Female; Fluconazole; Hematologic Neoplasms; Hematopoietic Stem Cell Transplantation; Humans; Immunocompromised Host; Itraconazole; Lung Diseases, Fungal; Male; Middle Aged; Mucormycosis; Neutropenia; Pyrimidines; Sinusitis; Transplantation Conditioning; Triazoles; Viscera; Voriconazole | 2005 |
Autologous transplantation of CD133 selected hematopoietic progenitor cells for treatment of relapsed acute lymphoblastic leukemia.
Topics: AC133 Antigen; Amphotericin B; Antifungal Agents; Antigens, CD; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Caspofungin; Child; Combined Modality Therapy; Contraindications; Dexamethasone; Drug Therapy, Combination; Echinocandins; Glycoproteins; Humans; Immunomagnetic Separation; Lipopeptides; Male; Mercaptopurine; Methotrexate; Peptides; Peptides, Cyclic; Peripheral Blood Stem Cell Transplantation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Recurrence; Remission Induction; Salvage Therapy; Transplantation, Autologous; Transplantation, Homologous; Triazoles; Vincristine; Voriconazole; Zygomycosis | 2007 |
[Physiological comportment and in vivo sensitivity of Sporothrix schenckii isolates maintained for 18 years by two preservation methods].
Topics: Agar; Antifungal Agents; Drug Resistance, Fungal; Glucose; Itraconazole; Microbial Sensitivity Tests; Mycology; Naphthalenes; Potassium Iodide; Preservation, Biological; Sporothrix; Starch; Terbinafine; Time Factors; Triazoles; Water | 2005 |
Pulmonary mucormycosis (zygomycosis) in a lung transplant recipient: recovery after posaconazole therapy.
Topics: Absidia; Antifungal Agents; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Bronchoscopy; Fatal Outcome; Female; Follow-Up Studies; Humans; Lung Diseases, Fungal; Lung Transplantation; Middle Aged; Mucormycosis; Pulmonary Fibrosis; Tomography, X-Ray Computed; Triazoles | 2005 |
Amiodarone has intrinsic anti-Trypanosoma cruzi activity and acts synergistically with posaconazole.
Topics: Acute Disease; Amiodarone; Animals; Calcium; Chagas Disease; Chlorocebus aethiops; Crystallography, X-Ray; Drug Synergism; Ergosterol; Intramolecular Transferases; Mice; Models, Molecular; Molecular Structure; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2006 |
Epidemiology of candidaemia and antifungal susceptibility patterns in an Italian tertiary-care hospital.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antifungal Agents; Candida; Candidiasis; Child; Child, Preschool; Cross Infection; Drug Resistance, Fungal; Female; Fungemia; Hospitals, University; Humans; Infant; Infant, Newborn; Italy; Male; Microbial Sensitivity Tests; Middle Aged; Prevalence; Triazoles | 2006 |
Head-to-head comparison of the activities of currently available antifungal agents against 3,378 Spanish clinical isolates of yeasts and filamentous fungi.
Topics: Amphotericin B; Antifungal Agents; Caspofungin; Echinocandins; Fluconazole; Flucytosine; Fungi; Humans; Itraconazole; Lipopeptides; Microbial Sensitivity Tests; Mycoses; Peptides, Cyclic; Pyrimidines; Spain; Triazoles; Voriconazole; Yeasts | 2006 |
Evaluation of disk diffusion method for determining posaconazole susceptibility of filamentous fungi: comparison with CLSI broth microdilution method.
Topics: Antifungal Agents; Culture Media; Evaluation Studies as Topic; Fungi; Humans; Microbial Sensitivity Tests; Regression Analysis; Triazoles | 2006 |
Posaconazole is effective as salvage therapy in zygomycosis: a retrospective summary of 91 cases.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antifungal Agents; Child; Female; Humans; Male; Middle Aged; Retrospective Studies; Salvage Therapy; Triazoles; Zygomycosis | 2006 |
Oropharyngeal candidiasis: a new treatment option.
Topics: AIDS-Related Opportunistic Infections; Antifungal Agents; Candida albicans; Candidiasis; Candidiasis, Oral; Clinical Trials as Topic; Humans; Pharyngeal Diseases; Triazoles | 2006 |
Control of a Candida glabrata prosthetic endovascular infection with posaconazole.
Topics: Candida glabrata; Candidiasis; Drug Resistance, Fungal; Drug Therapy, Combination; Fluconazole; Humans; Male; Middle Aged; Portasystemic Shunt, Transjugular Intrahepatic; Triazoles | 2006 |
Cytoskeleton reassembly in cardiomyocytes infected by Trypanosoma cruzi is triggered by treatment with ergosterol biosynthesis inhibitors.
Topics: Animals; Cells, Cultured; Cytoskeleton; Ergosterol; Ketoconazole; Mice; Myocytes, Cardiac; Myofibrils; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2006 |
Pharmacokinetics and safety of oral posaconazole in neutropenic stem cell transplant recipients.
Topics: Antifungal Agents; Area Under Curve; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Monitoring; Female; Humans; Male; Middle Aged; Mucositis; Neutropenia; Severity of Illness Index; Stem Cell Transplantation; Triazoles | 2006 |
In vitro activities of posaconazole, fluconazole, itraconazole, voriconazole, and amphotericin B against a large collection of clinically important molds and yeasts.
Topics: Amphotericin B; Antifungal Agents; Aspergillosis; Aspergillus; Candida; Candidiasis; Cryptococcosis; Cryptococcus; Drug Resistance, Fungal; Fluconazole; Fungi; Humans; In Vitro Techniques; Itraconazole; Microbial Sensitivity Tests; Mycoses; Pyrimidines; Triazoles; Voriconazole | 2006 |
In vitro activities of 10 combinations of antifungal agents against the multiresistant pathogen Scopulariopsis brevicaulis.
Topics: Amphotericin B; Antifungal Agents; Caspofungin; Drug Resistance, Multiple, Fungal; Drug Synergism; Echinocandins; Humans; In Vitro Techniques; Itraconazole; Lipopeptides; Microbial Sensitivity Tests; Mitosporic Fungi; Naphthalenes; Peptides, Cyclic; Pyrimidines; Terbinafine; Triazoles; Voriconazole | 2006 |
Importance of identification of zygomycetes in the era of newer antifungal agents.
Topics: Amphotericin B; Antifungal Agents; Gastrointestinal Diseases; Humans; Kidney Transplantation; Triazoles; Zygomycosis | 2006 |
Correlation between microdilution, E-test, and disk diffusion methods for antifungal susceptibility testing of posaconazole against Candida spp.
Topics: Antifungal Agents; Candida; Candida albicans; Candidiasis; Drug Resistance, Fungal; Fungemia; Humans; Microbial Sensitivity Tests; Triazoles | 2006 |
Treatment of cavitary pulmonary zygomycosis with surgical resection and posaconazole.
Topics: Amphotericin B; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Benzamides; Bone Marrow Transplantation; Cefepime; Cephalosporins; Combined Modality Therapy; Cunninghamella; Daunorubicin; Drug Resistance, Multiple, Fungal; Female; Humans; Imatinib Mesylate; Immunocompromised Host; Lung Diseases, Fungal; Middle Aged; Neutropenia; Piperazines; Pneumonectomy; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Pyrimidines; Transplantation Conditioning; Triazoles; Vancomycin; Vincristine; Voriconazole; Zygomycosis | 2006 |
Interaction between posaconazole and caspofungin in concomitant treatment of mice with systemic Aspergillus infection.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus flavus; Aspergillus fumigatus; Caspofungin; Drug Interactions; Drug Therapy, Combination; Echinocandins; Lipopeptides; Male; Mice; Microbial Sensitivity Tests; Peptides, Cyclic; Triazoles | 2006 |
Periorbital zygomycosis (mucormycosis) treated with posaconazole.
Topics: Adult; Antifungal Agents; Antineoplastic Agents; Eye Infections, Fungal; Humans; Male; Microbial Sensitivity Tests; Mucormycosis; Orbital Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Rhizopus; Tomography, X-Ray Computed; Triazoles | 2006 |
First case of Penicillium marneffei fungemia in Greece and strain susceptibility to five licensed systemic antifungal agents and posaconazole.
Topics: Antifungal Agents; Drug Resistance, Bacterial; Fungemia; Greece; HIV Infections; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Penicillium; Triazoles | 2006 |
A sensitive liquid chromatography and mass spectrometry method for the determination of posaconazole in human plasma.
Topics: Antifungal Agents; Calibration; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Mass Spectrometry; Quality Control; Reference Standards; Reproducibility of Results; Solutions; Triazoles | 2007 |
Evaluation of automated micro solid phase extraction tips (micro-SPE) for the validation of a LC-MS/MS bioanalytical method.
Topics: Animals; Automation; Chromatography, Liquid; Rats; Reproducibility of Results; Solid Phase Microextraction; Tandem Mass Spectrometry; Triazoles | 2006 |
Successful use of posaconazole in a pediatric case of fungal necrotizing fasciitis.
Topics: Amphotericin B; Antifungal Agents; Child; Drug Therapy, Combination; Fasciitis, Necrotizing; Female; Humans; Mucormycosis; Mycoses; Triazoles; Trichosporon | 2006 |
Comparison of the EUCAST-AFST broth dilution method with the CLSI reference broth dilution method (M38-A) for susceptibility testing of posaconazole and voriconazole against Aspergillus spp.
Topics: Antifungal Agents; Aspergillus; Humans; Microbial Sensitivity Tests; Pyrimidines; Triazoles; Voriconazole | 2006 |
Comparison of three commercial assays and a modified disk diffusion assay with two broth microdilution reference assays for testing zygomycetes, Aspergillus spp., Candida spp., and Cryptococcus neoformans with posaconazole and amphotericin B.
Topics: Amphotericin B; Antifungal Agents; Aspergillus; Candida; Cryptococcus neoformans; Drug Resistance, Fungal; Microbial Sensitivity Tests; Mycological Typing Techniques; Triazoles | 2006 |
HPLC analysis of the antifungal agent posaconazole in patients with haematological diseases.
Topics: Antifungal Agents; Biological Availability; Chromatography, High Pressure Liquid; Drug Monitoring; Hematologic Diseases; Humans; Mycoses; Triazoles | 2006 |
Successful treatment of disseminated mucormycosis with a combination of liposomal amphotericin B and posaconazole in a patient with acute myeloid leukaemia.
Topics: Amphotericin B; Antifungal Agents; Drug Therapy, Combination; Female; Humans; Leukemia, Myeloid, Acute; Liposomes; Middle Aged; Mucormycosis; Rhizomucor; Treatment Outcome; Triazoles | 2006 |
Rhinocerebral zygomycosis in a young girl undergoing allogeneic stem cell transplantation for severe aplastic anaemia.
Topics: Absidia; Alternaria; Amphotericin B; Anemia, Aplastic; Antifungal Agents; Central Nervous System Fungal Infections; Child; Female; Humans; Radiography; Sinusitis; Stem Cell Transplantation; Telencephalon; Transplantation, Homologous; Triazoles; Zygomycosis | 2006 |
Posaconazole for treatment of refractory invasive fungal disease.
Topics: Antifungal Agents; Aspergillosis; Aspergillus nidulans; Central Nervous System Fungal Infections; Child; Child, Preschool; Diabetes Mellitus, Type 1; Drug Resistance, Fungal; Female; Granulomatous Disease, Chronic; Humans; Immunocompromised Host; Lung Diseases, Fungal; Male; Mucormycosis; Rhizopus; Sinusitis; Treatment Outcome; Triazoles | 2006 |
Salvage therapy of refractory chronic disseminated candidiasis in a patient with acute myeloid leukaemia and secondary prophylaxis during allogeneic stem cell transplantation.
Topics: Adult; Antifungal Agents; Candidiasis; Chemoprevention; Drug Resistance, Fungal; Esophagitis; Humans; Leukemia, Myeloid, Acute; Male; Mycoses; Salvage Therapy; Stem Cell Transplantation; Transplantation, Homologous; Triazoles | 2006 |
Molecular basis for enhanced activity of posaconazole against Absidia corymbifera and Rhizopus oryzae.
Topics: Absidia; Amino Acid Sequence; Antifungal Agents; Cytochrome P-450 Enzyme System; Ergosterol; Microbial Sensitivity Tests; Molecular Sequence Data; Oxidoreductases; Rhizopus; Saccharomyces cerevisiae; Sterol 14-Demethylase; Triazoles | 2006 |
Antifungal susceptibilities of the species of the Pseudallescheria boydii complex.
Topics: Amphotericin B; Antifungal Agents; Candida; Drug Resistance, Fungal; Echinocandins; Fluconazole; Flucytosine; Humans; Itraconazole; Ketoconazole; Lipopeptides; Lipoproteins; Micafungin; Microbial Sensitivity Tests; Naphthalenes; Peptides, Cyclic; Pseudallescheria; Pyrimidines; Quality Control; Quinazolines; Scedosporium; Terbinafine; Thiazoles; Triazoles; Voriconazole | 2006 |
Chronic refractory phaeohyphomycosis: successful treatment with posaconazole.
Topics: Adolescent; Adult; Alternaria; Amphotericin B; Antifungal Agents; Chronic Disease; Deoxycholic Acid; Drug Combinations; Female; Humans; Mouth Diseases; Mycoses; Treatment Outcome; Triazoles | 2006 |
Multi-azole resistance in Aspergillus fumigatus.
Topics: Amphotericin B; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Caspofungin; Cytochrome P-450 Enzyme System; Drug Resistance, Multiple, Fungal; Echinocandins; Fungal Proteins; Humans; Itraconazole; Lipopeptides; Lung Diseases, Fungal; Male; Microbial Sensitivity Tests; Middle Aged; Mutation, Missense; Peptides, Cyclic; Pyrimidines; Thiazoles; Triazoles; Voriconazole | 2006 |
Posaconazole prophylaxis in experimental systemic zygomycosis.
Topics: Absidia; Amphotericin B; Animals; Antibiotic Prophylaxis; Antifungal Agents; Brain; Cells, Cultured; Disease Models, Animal; Kidney; Lung; Male; Mice; Microbial Sensitivity Tests; Mucormycosis; Rhizopus; Spleen; Time Factors; Triazoles | 2007 |
Quality control limits for posaconazole disk susceptibility tests on Mueller-Hinton agar with glucose and methylene blue.
Topics: Agar; Antifungal Agents; Candida; Candida albicans; Candida tropicalis; Culture Media; Glucose; Methylene Blue; Microbial Sensitivity Tests; Quality Control; Triazoles | 2007 |
Effects of age, gender, and race/ethnicity on the pharmacokinetics of posaconazole in healthy volunteers.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antifungal Agents; Black People; Drug Resistance, Multiple; Female; Humans; Male; Middle Aged; Sex Factors; Triazoles; White People | 2007 |
Posaconazole (Noxafil) for invasive fungal infections.
Topics: Antifungal Agents; Candidiasis, Oral; Drug Interactions; Humans; Mycoses; Triazoles | 2006 |
Posaconazole enhances the activity of amphotericin B against Aspergillus hyphae in vitro.
Topics: Amphotericin B; Antifungal Agents; Aspergillosis; Aspergillus; Drug Synergism; Drug Therapy, Combination; Microbial Sensitivity Tests; Pyrimidines; Triazoles; Voriconazole | 2007 |
The Anti-Trypanosoma cruzi activity of posaconazole in a murine model of acute Chagas' disease is less dependent on gamma interferon than that of benznidazole.
Topics: Animals; Chagas Disease; Interferon-gamma; Interleukin-12; Mice; Mice, Inbred C57BL; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2007 |
Prophylaxis and aspergillosis--has the principle been proven?
Topics: Antifungal Agents; Aspergillosis; Fluconazole; Graft vs Host Disease; Humans; Itraconazole; Mycoses; Neutropenia; Opportunistic Infections; Triazoles | 2007 |
Posaconazole as salvage therapy in a patient with disseminated zygomycosis: case report and review of the literature.
Topics: Adult; Disease-Free Survival; Humans; Male; Mucor; Salvage Therapy; Triazoles; Zygomycosis | 2007 |
Successful treatment of resistant ocular fusariosis with posaconazole (SCH-56592).
Topics: Administration, Oral; Adult; Antifungal Agents; Corneal Ulcer; Eye Infections, Fungal; Female; Fusarium; Humans; Male; Middle Aged; Mycoses; Retrospective Studies; Triazoles | 2007 |
Drug approvals.
Topics: Acetanilides; Alprostadil; Angina Pectoris; Benzazepines; Bone Density Conservation Agents; Diphosphonates; Drug Administration Schedule; Drug Approval; Drug Therapy; Drug-Related Side Effects and Adverse Reactions; Enzyme Inhibitors; Fatty Acids; Herpes Zoster Vaccine; Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18; Humans; Ibandronic Acid; Insulin; Lubiprostone; Naltrexone; Narcotic Antagonists; Nurse's Role; Papillomavirus Vaccines; Patient Education as Topic; Piperazines; Quinoxalines; Ranolazine; Triazoles; United States; United States Food and Drug Administration; Varenicline | 2007 |
Evaluation of disk diffusion and Etest compared to broth microdilution for antifungal susceptibility testing of posaconazole against clinical isolates of filamentous fungi.
Topics: Antifungal Agents; Fungi; Humans; Microbial Sensitivity Tests; Mycoses; Triazoles | 2007 |
Possible increase of the neurotoxicity of vincristine by the concurrent use of posaconazole in a young adult with leukemia.
Topics: Adult; Antifungal Agents; Antineoplastic Agents; Demyelinating Diseases; Electromyography; Fever; Humans; Lung Diseases; Male; Neural Conduction; Neurotoxicity Syndromes; Neutropenia; Peripheral Nervous System Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Triazoles; Vincristine | 2007 |
Evaluation of Etest and disk diffusion methods compared with broth microdilution antifungal susceptibility testing of clinical isolates of Candida spp. against posaconazole.
Topics: Agar; Antifungal Agents; Candida; Candidiasis; Culture Media; Disk Diffusion Antimicrobial Tests; Humans; Microbial Sensitivity Tests; Triazoles | 2007 |
Posaconazole treatment for Apophysomyces elegans rhino-orbital zygomycosis following trauma for a male with well-controlled diabetes.
Topics: Adult; Antifungal Agents; Dermatomycoses; Diabetes Mellitus; Fungi; Humans; Male; Triazoles; Zygomycosis | 2007 |
Posaconazole.
Topics: Administration, Oral; Antifungal Agents; Aspergillosis; Candidiasis; Capsules; Drug Approval; Drug Design; Economics, Pharmaceutical; Fluconazole; Humans; Injections, Intravenous; Itraconazole; Molecular Structure; Randomized Controlled Trials as Topic; Suspensions; Technology, Pharmaceutical; Treatment Failure; Triazoles; United States | 2007 |
Clinical evaluation of the Sensititre YeastOne plate for testing susceptibility of filamentous fungi to posaconazole.
Topics: Antifungal Agents; Colorimetry; Fungi; Humans; Microbial Sensitivity Tests; Mitosporic Fungi; Reference Standards; Triazoles | 2007 |
Multicenter evaluation of a new disk agar diffusion method for susceptibility testing of filamentous fungi with voriconazole, posaconazole, itraconazole, amphotericin B, and caspofungin.
Topics: Amphotericin B; Antifungal Agents; Caspofungin; Culture Media; Disk Diffusion Antimicrobial Tests; Echinocandins; Fungi; Itraconazole; Lipopeptides; Microbial Sensitivity Tests; Peptides, Cyclic; Pyrimidines; Reproducibility of Results; Triazoles; Voriconazole | 2007 |
Rhizopus microsporus var. rhizopodiformis sinus-orbital zygomycosis in an immunosuppressed patient: successful treatment with posaconazole after a complicated clinical course.
Topics: Adult; Amphotericin B; Eye Infections, Fungal; Hematologic Diseases; Hematopoietic Stem Cell Transplantation; Humans; Immunocompromised Host; Male; Orbital Diseases; Paranasal Sinus Diseases; Rhizopus; Soil; Soil Microbiology; Transplantation, Homologous; Triazoles; Zygomycosis | 2007 |
In vitro susceptibilities of 217 clinical isolates of zygomycetes to conventional and new antifungal agents.
Topics: Amphotericin B; Antifungal Agents; Caspofungin; Echinocandins; Fluconazole; Flucytosine; Humans; In Vitro Techniques; Itraconazole; Ketoconazole; Lipopeptides; Microbial Sensitivity Tests; Mucormycosis; Peptides, Cyclic; Pyrimidines; Triazoles; Voriconazole | 2007 |
Mucormycosis in patients with complicated cirrhosis.
Topics: Antifungal Agents; Humans; Liver Cirrhosis; Mucormycosis; Triazoles | 2007 |
Posaconazole salvage therapy allows successful allogeneic hematopoietic stem cell transplantation in patients with refractory invasive mold infections.
Topics: Adult; Antifungal Agents; Female; Hematopoietic Stem Cell Transplantation; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Multiple Myeloma; Mycoses; Prospective Studies; Salvage Therapy; Transplantation, Homologous; Triazoles | 2007 |
Successful treatment of disseminated fusariosis with posaconazole during neutropenia and subsequent allogeneic hematopoietic stem cell transplantation.
Topics: Adolescent; Antifungal Agents; Female; Fusarium; Hematopoietic Stem Cell Transplantation; Humans; Leukemia, Myeloid, Acute; Mycoses; Neutropenia; Triazoles | 2007 |
Therapeutic efficacy of posaconazole against isolates of Candida albicans with different susceptibilities to fluconazole in a vaginal model.
Topics: Animals; Antifungal Agents; Candida albicans; Candidiasis, Vulvovaginal; Colony Count, Microbial; Disease Models, Animal; Drug Resistance, Fungal; Female; Fluconazole; Humans; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Triazoles; Vagina | 2007 |
Successful treatment and limb salvage of mucor necrotizing fasciitis after kidney transplantation with posaconazole.
Topics: Alcaligenes; Amphotericin B; Amputation, Surgical; Antifungal Agents; Cefazolin; Combined Modality Therapy; Debridement; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Drug Combinations; Drug Resistance, Multiple, Fungal; Escherichia coli Infections; Fatal Outcome; Fluconazole; Gangrene; Graft Rejection; Gram-Negative Bacterial Infections; Humans; Immunocompromised Host; Immunosuppressive Agents; Kidney Transplantation; Leg; Leg Ulcer; Male; Middle Aged; Mucor; Mucormycosis; Penicillanic Acid; Phosphatidylcholines; Phosphatidylglycerols; Piperacillin; Postoperative Complications; Pyrimidines; Renal Dialysis; Reoperation; Sepsis; Skin Transplantation; Tazobactam; Triazoles; Voriconazole | 2007 |
Posaconazole susceptibility testing against Candida species: comparison of broth microdilution and E-test methods.
Topics: Antifungal Agents; Candida; Candida albicans; Candidiasis; Dimethyl Sulfoxide; Drug Resistance, Fungal; Fluconazole; Humans; Microbial Sensitivity Tests; Polyethylene Glycols; Solvents; Triazoles | 2007 |
Inherited long QT syndrome revealed by antifungals drug-drug interaction.
Topics: Acute Disease; Adolescent; Antifungal Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Female; Genotype; Humans; Injections, Intravenous; Leukemia, Myeloid; Long QT Syndrome; Mixed Function Oxygenases; Mucormycosis; Pyrimidines; Torsades de Pointes; Triazoles; Voriconazole | 2007 |
[Correlations among itraconazole, voriconazole and posaconazole MICs in Aspergillus fumigatus].
Topics: Antifungal Agents; Aspergillus fumigatus; Drug Resistance, Fungal; Itraconazole; Microbial Sensitivity Tests; Pyrimidines; Triazoles; Voriconazole | 2007 |
Posaconazole prophylaxis in hematologic cancer.
Topics: Antifungal Agents; Drug Resistance, Fungal; Fluconazole; Humans; Itraconazole; Leukemia, Myeloid, Acute; Mycoses; Opportunistic Infections; Triazoles | 2007 |
Posaconazole prophylaxis in hematologic cancer.
Topics: Antifungal Agents; Fluconazole; Humans; Itraconazole; Leukemia, Myeloid, Acute; Mycoses; Myelodysplastic Syndromes; Opportunistic Infections; Research Design; Triazoles | 2007 |
Posaconazole prophylaxis in hematologic cancer.
Topics: Antifungal Agents; Aspergillosis; Aspergillus; Cytochrome P-450 Enzyme System; Drug Resistance, Fungal; Humans; Mucositis; Mycoses; Opportunistic Infections; Oxidoreductases; Point Mutation; Pyrimidines; Sterol 14-Demethylase; Triazoles; Voriconazole | 2007 |
Posaconazole prophylaxis in hematologic cancer.
Topics: Antifungal Agents; Bilirubin; Chemical and Drug Induced Liver Injury; Fluconazole; Graft vs Host Disease; Humans; Liver Diseases; Mycoses; Transaminases; Triazoles | 2007 |
Antimicrobial susceptibility of Fusarium, Aspergillus, and other filamentous fungi isolated from keratitis.
Topics: Amphotericin B; Antifungal Agents; Aspergillus; Caspofungin; Corneal Ulcer; Echinocandins; Eye Infections, Fungal; Fusarium; Humans; Itraconazole; Lipopeptides; Microbial Sensitivity Tests; Natamycin; Peptides, Cyclic; Prospective Studies; Pyrimidines; Triazoles; Voriconazole | 2007 |
Rhino-orbital mucormycosis causing cavernous sinus and internal carotid thrombosis treated with posaconazole.
Topics: Antifungal Agents; Carotid Artery Thrombosis; Carotid Artery, Internal; Cavernous Sinus Thrombosis; Child; Debridement; Female; Humans; Magnetic Resonance Imaging; Mucor; Mucormycosis; Orbital Diseases; Paranasal Sinus Diseases; Triazoles | 2007 |
Synergistic effect of posaconazole and caspofungin against clinical zygomycetes.
Topics: Antifungal Agents; Caspofungin; Drug Synergism; Echinocandins; Fungi; Lipopeptides; Microbial Sensitivity Tests; Triazoles | 2007 |
In vitro susceptibility to posaconazole of 1,903 yeast isolates recovered in France from 2003 to 2006 and tested by the method of the European committee on antimicrobial susceptibility testing.
Topics: Antifungal Agents; Fluconazole; France; Humans; Microbial Sensitivity Tests; Mycoses; Pyrimidines; Triazoles; Voriconazole; Yeasts | 2007 |
Posaconazole for azole-refractory candidiasis in patients with HIV infection.
Topics: AIDS-Related Opportunistic Infections; Antifungal Agents; Candidiasis; Drug Administration Schedule; Esophageal Diseases; Humans; Mouth Diseases; Pharyngeal Diseases; Triazoles | 2007 |
Early use of posaconazole in the successful treatment of rhino-orbital mucormycosis caused by Rhizopus oryzae.
Topics: Aged; Antifungal Agents; Ethmoid Sinusitis; Female; Humans; Male; Maxillary Sinusitis; Middle Aged; Mucormycosis; Rhizopus; Treatment Outcome; Triazoles | 2007 |
Posaconazole: a next-generation triazole antifungal.
Topics: Animals; Antifungal Agents; Aspergillus; Candida; Clinical Trials, Phase III as Topic; Drug Evaluation, Preclinical; Humans; Models, Animal; Molecular Structure; Mycoses; Triazoles | 2007 |
Posaconazole for the management of mucosal candidiasis.
Topics: Antifungal Agents; Antiretroviral Therapy, Highly Active; Candidiasis, Oral; HIV Infections; Humans; Molecular Structure; Randomized Controlled Trials as Topic; Triazoles | 2007 |
Posaconazole for invasive aspergillosis?
Topics: Antifungal Agents; Aspergillosis; Case-Control Studies; Humans; Reproducibility of Results; Salvage Therapy; Selection Bias; Triazoles | 2007 |
Breakthrough infection of Trichosporon asahii during posaconazole treatment in a patient with acute myeloid leukaemia.
Topics: Aged; Amphotericin B; Antifungal Agents; Cross Infection; Drug Therapy, Combination; Humans; Leukemia, Myeloid, Acute; Male; Mycoses; Pyrimidines; Triazoles; Trichosporon; Voriconazole | 2007 |
Lack of cross-hepatotoxicity between voriconazole and posaconazole.
Topics: Aged; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Chemical and Drug Induced Liver Injury; Humans; Pyrimidines; Triazoles; Voriconazole | 2007 |
Recalcitrant Beauveria bassiana keratitis: confocal microscopy findings and treatment with posaconazole (Noxafil).
Topics: Administration, Oral; Administration, Topical; Antifungal Agents; Beauveria; Cornea; Corneal Ulcer; Drug Therapy, Combination; Eye Infections, Fungal; Female; Humans; Microscopy, Confocal; Middle Aged; Mycoses; Pyrimidines; Triazoles; Voriconazole | 2007 |
Successfully treated Candida krusei infection of the lumbar spine with combined caspofungin/posaconazole therapy.
Topics: Antifungal Agents; Candida; Candidiasis; Caspofungin; Drug Therapy, Combination; Echinocandins; Humans; Lipopeptides; Lumbar Vertebrae; Magnetic Resonance Imaging; Male; Middle Aged; Osteomyelitis; Triazoles | 2008 |
Efficacy of posaconazole and amphotericin B in experimental invasive pulmonary aspergillosis in dexamethasone immunosuppressed rats.
Topics: Amphotericin B; Animals; Antifungal Agents; Aspergillosis, Allergic Bronchopulmonary; Aspergillus fumigatus; Dexamethasone; Dose-Response Relationship, Drug; Drug Resistance, Fungal; Drug Therapy, Combination; Immunocompromised Host; Male; Microbial Sensitivity Tests; Rats; Rats, Sprague-Dawley; Triazoles | 2007 |
Correlation of posaconazole minimum fungicidal concentration and time kill test against nine Candida species.
Topics: Antifungal Agents; Candida; Dose-Response Relationship, Drug; Drug Resistance, Fungal; Microbial Sensitivity Tests; Time Factors; Triazoles | 2007 |
Efficacy of caspofungin and posaconazole in a murine model of disseminated Exophiala infection.
Topics: Amphotericin B; Animals; Antifungal Agents; Brain; Caspofungin; Disease Models, Animal; Echinocandins; Exophiala; Female; Immunocompromised Host; Kidney; Lipopeptides; Mice; Mice, Inbred ICR; Mycoses; Survival Analysis; Triazoles | 2007 |
Effect of calcineurin inhibitors on posaconazole blood levels as measured by the MVista microbiological assay.
Topics: Antifungal Agents; Calcineurin Inhibitors; Cyclosporine; Drug Interactions; False Positive Reactions; Graft vs Host Disease; Humans; Immunosuppressive Agents; Microbiological Techniques; Sirolimus; Tacrolimus; Triazoles | 2008 |
Comparison of disc diffusion assay with the CLSI reference method (M27-A2) for testing in vitro posaconazole activity against common and uncommon yeasts.
Topics: Antifungal Agents; Candida; Candidiasis; Drug Resistance, Fungal; Humans; Microbial Sensitivity Tests; Reference Standards; Reproducibility of Results; Triazoles | 2008 |
Posaconazole activity against Candida glabrata after exposure to caspofungin or amphotericin B.
Topics: Amphotericin B; Animals; Antifungal Agents; Candida glabrata; Candidiasis; Caspofungin; Colony Count, Microbial; Drug Administration Schedule; Echinocandins; Humans; Kidney; Lipopeptides; Male; Mice; Microbial Sensitivity Tests; Treatment Outcome; Triazoles | 2008 |
Posaconazole (Noxafil, SCH 56592), a new azole antifungal drug, was a discovery based on the isolation and mass spectral characterization of a circulating metabolite of an earlier lead (SCH 51048).
Topics: Animals; Antifungal Agents; Chromatography, High Pressure Liquid; Dogs; Drug Design; Macaca fascicularis; Male; Mass Spectrometry; Mice; Mice, Inbred Strains; Rabbits; Triazoles | 2008 |
Selection of a surrogate agent (fluconazole or voriconazole) for initial susceptibility testing of posaconazole against Candida spp.: results from a global antifungal surveillance program.
Topics: Antifungal Agents; Biomarkers; Candida; Candidiasis; Fluconazole; Humans; Microbial Sensitivity Tests; Pyrimidines; Regression Analysis; Triazoles; Voriconazole | 2008 |
[Invasive zygomycosis in patients treated for haematological malignancies].
Topics: Adolescent; Amphotericin B; Antifungal Agents; Child, Preschool; Fatal Outcome; Hematopoietic Stem Cell Transplantation; Humans; Immunocompromised Host; Male; Middle Aged; Mucormycosis; Organ Transplantation; Rhizopus; Transplantation Immunology; Triazoles; Zygomycosis | 2007 |
Progressive fusariosis: unpredictable posaconazole bioavailability, and feasibility of recombinant interferon-gamma plus granulocyte macrophage-colony stimulating factor for refractory disseminated infection.
Topics: Adult; Biological Availability; Fusarium; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunocompromised Host; Interferon-gamma; Leukemia; Male; Mycoses; Neutropenia; Recombinant Proteins; Salvage Therapy; Treatment Outcome; Triazoles | 2008 |
In vitro activities of combinations of amphotericin B, posaconazole and four other agents against Rhizopus.
Topics: Amphotericin B; Drug Combinations; Drug Synergism; Humans; Rhizopus; Triazoles | 2008 |
Multilaboratory testing of antifungal combinations against a quality control isolate of Candida krusei.
Topics: Amphotericin B; Antifungal Agents; Candida; Caspofungin; Drug Therapy, Combination; Echinocandins; Humans; Laboratories; Lipopeptides; Microbial Sensitivity Tests; Pyrimidines; Quality Control; Triazoles; Voriconazole | 2008 |
Interaction of amphotericin B lipid formulations and triazoles with human polymorphonuclear leucocytes for antifungal activity against Zygomycetes.
Topics: Absidia; Adult; Amphotericin B; Antifungal Agents; Drug Combinations; Drug Interactions; Humans; Hyphae; Liposomes; Microbial Sensitivity Tests; Neutrophils; Phosphatidylcholines; Phosphatidylglycerols; Pyrimidines; Rhizopus; Triazoles; Voriconazole | 2008 |
Beta-D-glucan detection test: a step toward preemptive therapy for fungal infections in leukemic patients?
Topics: Antifungal Agents; Antigens, Fungal; Aspergillosis; beta-Glucans; Candidiasis; Chemoprevention; Humans; Leukemia; Proteoglycans; Triazoles | 2008 |
Mucormycoses: serious complication of high-dose corticosteroid therapy for traumatic optic neuropathy.
Topics: Abscess; Antifungal Agents; Glucocorticoids; Humans; Jaw Fractures; Male; Methylprednisolone; Middle Aged; Mucormycosis; Optic Nerve Diseases; Retrobulbar Hemorrhage; Streptococcal Infections; Triazoles | 2008 |
[In vitro susceptibility of isolates of Scytalidium spp. from superficial lesions against posaconazole].
Topics: Antifungal Agents; Ascomycota; Dermatomycoses; Drug Resistance, Fungal; Foot Dermatoses; Humans; Microbial Sensitivity Tests; Mitosporic Fungi; Onychomycosis; Triazoles | 2008 |
[Antifungal activity of posaconazole and caspofungin in yeast causing invasive fungal infection (2002-2003). E-test system evaluation].
Topics: Antifungal Agents; Candida; Caspofungin; Cryptococcus; Echinocandins; Humans; Lipopeptides; Microbial Sensitivity Tests; Mycoses; Rhodotorula; Sensitivity and Specificity; Species Specificity; Triazoles | 2008 |
MICs and minimum fungicidal concentrations of posaconazole, voriconazole and fluconazole for Cryptococcus neoformans and Cryptococcus gattii.
Topics: Animals; Antifungal Agents; Bird Diseases; Columbidae; Cryptococcosis; Cryptococcus; Fluconazole; Humans; Microbial Sensitivity Tests; Microbial Viability; Pyrimidines; Triazoles; Voriconazole | 2008 |
In vitro antifungal susceptibility and molecular characterization of clinical isolates of Fusarium verticillioides (F. moniliforme) and Fusarium thapsinum.
Topics: Animals; Antifungal Agents; Drug Resistance, Fungal; Fusarium; Humans; Microbial Sensitivity Tests; Molecular Sequence Data; Mycoses; Naphthalenes; Sequence Analysis, DNA; Terbinafine; Triazoles; Tubulin | 2008 |
Posaconazole against Candida glabrata isolates with various susceptibilities to fluconazole.
Topics: Animals; Antifungal Agents; Candida glabrata; Candidiasis; Drug Resistance, Fungal; Fluconazole; Humans; Kidney; Male; Mice; Microbial Sensitivity Tests; Treatment Outcome; Triazoles | 2008 |
Numbers needed to treat with posaconazole prophylaxis to prevent invasive fungal infection and death.
Topics: Antifungal Agents; Chemoprevention; Humans; Mycoses; Triazoles | 2008 |
The effect of gastric Acid on the absorption of posaconazole.
Topics: Antifungal Agents; Cimetidine; Drug Interactions; Gastric Acid; Humans; Triazoles | 2008 |
Posaconazole as first line treatment for disseminated zygomycosis.
Topics: Antifungal Agents; Female; Hip Prosthesis; Humans; Immunocompromised Host; Lung Diseases, Fungal; Lupus Erythematosus, Systemic; Middle Aged; Prosthesis-Related Infections; Rhizopus; Triazoles; Zygomycosis | 2008 |
Posaconazole enhances the activity of amphotericin B against hyphae of zygomycetes in vitro.
Topics: Absidia; Amphotericin B; Antifungal Agents; Cunninghamella; Drug Synergism; Humans; Hyphae; Microbial Sensitivity Tests; Mucor; Mucorales; Mucormycosis; Rhizomucor; Rhizopus; Spores, Fungal; Triazoles | 2008 |
In vitro susceptibilities of invasive isolates of Candida species: rapid increase in rates of fluconazole susceptible-dose dependent Candida glabrata isolates.
Topics: Anidulafungin; Antifungal Agents; Candida; Candida glabrata; Caspofungin; Echinocandins; Fluconazole; Lipopeptides; Micafungin; Microbial Sensitivity Tests; Pyrimidines; Triazoles; Voriconazole | 2008 |
[New systemic antifungal drugs].
Topics: Antifungal Agents; Humans; Pyrimidines; Triazoles; Voriconazole | 2008 |
Rhino-cerebral zygomycosis resistant to antimycotic treatment: a case report.
Topics: Aged; Amphotericin B; Anti-Inflammatory Agents; Antifungal Agents; Central Nervous System Diseases; Drug Resistance, Fungal; Fatal Outcome; Humans; Male; Methylprednisolone; Purpura, Thrombocytopenic, Idiopathic; Pyrimidines; Rhinitis; Rhizopus; Triazoles; Voriconazole; Zygomycosis | 2009 |
Breakthrough disseminated Scedosporium prolificans infection in a patient with relapsed leukaemia on prolonged voriconazole followed by posaconazole prophylaxis.
Topics: Administration, Oral; Antifungal Agents; Antineoplastic Agents; Fatal Outcome; Humans; Leukemia; Male; Middle Aged; Mycetoma; Opportunistic Infections; Pyrimidines; Recurrence; Scedosporium; Triazoles; Voriconazole | 2008 |
Does pre-exposure of Aspergillus fumigatus to voriconazole or posaconazole in vitro affect its virulence and the in vivo activity of subsequent posaconazole or voriconazole, respectively? A study in a fly model of aspergillosis.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Drosophila melanogaster; Drosophila Proteins; Pyrimidines; Survival Analysis; Toll-Like Receptors; Triazoles; Virulence; Voriconazole | 2008 |
In vitro susceptibility of Cryptococcus gattii clinical isolates.
Topics: Amphotericin B; Antifungal Agents; Cryptococcus; Cryptococcus neoformans; Drug Resistance, Fungal; Fluconazole; Flucytosine; Humans; Microbial Sensitivity Tests; Triazoles | 2008 |
Fatal Aspergillus fumigatus and Candida glabrata infections with posaconazole prophylaxis after stem cell transplantation.
Topics: Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Candida glabrata; Candidiasis; Chemoprevention; Fatal Outcome; Humans; Male; Middle Aged; Stem Cell Transplantation; Triazoles | 2008 |
Treatment of aspergillosis.
Topics: Antifungal Agents; Aspergillosis; Fluconazole; Humans; Itraconazole; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Neutropenia; Triazoles | 2008 |
Investigation and management of an outbreak of mucormycosis in a paediatric oncology unit.
Topics: Adolescent; Antifungal Agents; Chemoprevention; Cross Infection; Disease Outbreaks; Environmental Microbiology; Hospital Units; Hospitals, University; Humans; Infant; Infection Control; Male; Mucormycosis; Neoplasms; Triazoles | 2008 |
Breakthrough Rhizopus infection on posaconazole prophylaxis following allogeneic stem cell transplantation.
Topics: Antifungal Agents; Humans; Lymphoma, Follicular; Male; Middle Aged; Mucormycosis; Rhinitis; Rhizopus; Sinusitis; Stem Cell Transplantation; Time Factors; Transplantation, Homologous; Triazoles | 2008 |
Trends in species distribution and susceptibility of bloodstream isolates of Candida collected in Monterrey, Mexico, to seven antifungal agents: results of a 3-year (2004 to 2007) surveillance study.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Amphotericin B; Antifungal Agents; Candida; Candida albicans; Candida glabrata; Candida tropicalis; Candidiasis; Caspofungin; Child; Child, Preschool; Echinocandins; Female; Fluconazole; Humans; Infant; Infant, Newborn; Itraconazole; Lipopeptides; Male; Mexico; Microbial Sensitivity Tests; Middle Aged; Pyrimidines; Thiazoles; Triazoles; Voriconazole; Young Adult | 2008 |
Successful therapy with ABLC, surgery and posaconazole for Rhizopus microsporus var. rhizopodiformis liver eumycetoma in a child with acute leukaemia.
Topics: Amphotericin B; Antifungal Agents; Drug Therapy, Combination; Humans; Infant; Leukemia, Myeloid, Acute; Liver; Liver Diseases; Male; Mycetoma; Rhizopus; Triazoles | 2009 |
Susceptibility testing of Cryptococcus diffluens against amphotericin B, flucytosine, fluconazole, itraconazole, voriconazole and posaconazole.
Topics: Amphotericin B; Antifungal Agents; Azoles; Cryptococcus; Culture Media; Drug Resistance, Fungal; Fluconazole; Flucytosine; Humans; Itraconazole; Microbial Sensitivity Tests; Pyrimidines; Triazoles; Voriconazole | 2009 |
Infection of the subcutis of the nose in a cat caused by Mucor species: successful treatment using posaconazole.
Topics: Animals; Antifungal Agents; Cat Diseases; Cats; Female; Mucor; Mucormycosis; Treatment Outcome; Triazoles | 2008 |
Comparison of posaconazole and voriconazole in vitro killing against Candida krusei.
Topics: Antifungal Agents; Candida; Candidiasis; Culture Media; Drug Resistance, Fungal; Fungemia; Humans; Microbial Sensitivity Tests; Pyrimidines; Time Factors; Triazoles; Voriconazole | 2008 |
Activities of antifungal agents against yeasts and filamentous fungi: assessment according to the methodology of the European Committee on Antimicrobial Susceptibility Testing.
Topics: Amphotericin B; Antifungal Agents; Aspergillus; Candida; Drug Resistance, Fungal; Europe; Fungi; Guidelines as Topic; Humans; Microbial Sensitivity Tests; Mycoses; Opportunistic Infections; Triazoles; Yeasts | 2008 |
Posaconazole combined with amphotericin B, an effective therapy for a murine disseminated infection caused by Rhizopus oryzae.
Topics: Amphotericin B; Animals; Antifungal Agents; Colony Count, Microbial; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Humans; Male; Mice; Mucormycosis; Rhizopus; Triazoles | 2008 |
Breakpoints for posaconazole susceptibility testing: background and discussion about the need of establishing values.
Topics: Antifungal Agents; Drug Resistance, Fungal; Endpoint Determination; Humans; Microbial Sensitivity Tests; Mycoses; Triazoles | 2008 |
Posaconazole in intensive care patients I: invasive fungal infections in surgical intensive care and case presentation.
Topics: Aged; Antifungal Agents; Aspergillosis; Candidiasis; Critical Care; Cross Infection; Humans; Middle Aged; Mycoses; Postoperative Complications; Triazoles | 2008 |
Breakthrough invasive fungal infection in an immunocompromised host while on posaconazole prophylaxis: an omission in patient counseling and follow-up.
Topics: Antibiotic Prophylaxis; Antifungal Agents; Antineoplastic Agents; Aspergillosis; Candidiasis; Female; Humans; Immunosuppression Therapy; Leukemia, Myeloid, Acute; Middle Aged; Mucormycosis; Paranasal Sinus Diseases; Patient Compliance; Patient Education as Topic; Triazoles | 2008 |
Economic evaluation of posaconazole vs. standard azole prophylaxis in high risk neutropenic patients in the Netherlands.
Topics: Adult; Aged; Antifungal Agents; Costs and Cost Analysis; Female; Fluconazole; Humans; Itraconazole; Leukemia, Myeloid, Acute; Male; Middle Aged; Models, Econometric; Mycoses; Myelodysplastic Syndromes; Netherlands; Neutropenia; Randomized Controlled Trials as Topic; Triazoles | 2008 |
Successful treatment of relapsing disseminated coccidioidomycosis with cutaneous involvement with posaconazole.
Topics: Antifungal Agents; Coccidioidomycosis; Dermatomycoses; Humans; In Vitro Techniques; Middle Aged; Secondary Prevention; Treatment Outcome; Triazoles | 2009 |
Posaconazole as salvage therapy in patients with invasive fungal infections after solid organ transplant.
Topics: Adult; Aged; Antifungal Agents; Aspergillosis; Candidiasis; Female; Humans; Immunosuppressive Agents; Incidence; Male; Middle Aged; Mycoses; Organ Transplantation; Postoperative Complications; Retrospective Studies; Safety; Treatment Outcome; Triazoles | 2008 |
Posaconazole concentrations in the central nervous system.
Topics: Adolescent; Adult; Antifungal Agents; Central Nervous System; Cerebrospinal Fluid; Female; Humans; Male; Middle Aged; Serum; Triazoles | 2008 |
Long-term posaconazole treatment and follow-up of rhino-orbital-cerebral mucormycosis in a diabetic girl.
Topics: Antifungal Agents; Central Nervous System Diseases; Child; Diabetes Mellitus, Type 1; Diabetic Ketoacidosis; Female; Follow-Up Studies; Humans; Mucormycosis; Nose Diseases; Orbital Diseases; Time Factors; Treatment Outcome; Triazoles | 2009 |
Posaconazole mono- or combination therapy for treatment of murine zygomycosis.
Topics: Amphotericin B; Animals; Antifungal Agents; Brain; Diabetic Ketoacidosis; Dose-Response Relationship, Drug; Drug Combinations; Kidney; Liposomes; Male; Mice; Mice, Inbred BALB C; Neutropenia; Rhizopus; Triazoles; Zygomycosis | 2009 |
Antifungal susceptibilities among different serotypes of Cryptococcus gattii and Cryptococcus neoformans.
Topics: Antifungal Agents; Cryptococcus; Cryptococcus neoformans; Fluconazole; Microbial Sensitivity Tests; Nitriles; Pyridines; Pyrimidines; Serotyping; Triazoles; Voriconazole | 2009 |
Development and validation of a high-performance liquid chromatography assay for posaconazole utilizing solid-phase extraction.
Topics: Antifungal Agents; Chromatography, High Pressure Liquid; Humans; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Triazoles | 2008 |
Disseminated Saksenaea vasiformis in an immunocompetent host.
Topics: Amphotericin B; Antifungal Agents; Child; Fungemia; Humans; Immunocompetence; Male; Mucorales; Mucormycosis; Plastic Surgery Procedures; Surgical Flaps; Triazoles | 2008 |
In vitro susceptibility of Pythium insidiosum and a Lagenidium sp to itraconazole, posaconazole, voriconazole, terbinafine, caspofungin, and mefenoxam.
Topics: Alanine; Anti-Infective Agents; Caspofungin; Echinocandins; In Vitro Techniques; Itraconazole; Lagenidium; Lipopeptides; Microbial Sensitivity Tests; Naphthalenes; Pyrimidines; Pythium; Terbinafine; Triazoles; Voriconazole | 2008 |
Emergence of azole resistance in Aspergillus fumigatus and spread of a single resistance mechanism.
Topics: Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Azoles; Drug Resistance, Multiple, Fungal; Humans; Itraconazole; Pyrimidines; Triazoles; Voriconazole | 2008 |
Absence of CD4+ T lymphocytes, CD8+ T lymphocytes, or B lymphocytes has different effects on the efficacy of posaconazole and benznidazole in treatment of experimental acute Trypanosoma cruzi infection.
Topics: Animals; B-Lymphocytes; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chagas Disease; Male; Mice; Mice, Knockout; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2009 |
International interlaboratory proficiency testing program for measurement of azole antifungal plasma concentrations.
Topics: Antifungal Agents; Azoles; Biological Assay; Fluconazole; Humans; Itraconazole; Pyrimidines; Triazoles; Voriconazole | 2009 |
Comparative cost-effectiveness of posaconazole versus fluconazole or itraconazole prophylaxis in patients with prolonged neutropenia.
Topics: Antifungal Agents; Clinical Trials as Topic; Cost-Benefit Analysis; Drug Therapy, Combination; Fluconazole; Humans; Itraconazole; Monte Carlo Method; Multicenter Studies as Topic; Mycoses; Neutropenia; Triazoles | 2008 |
Adverse drug events complicate antifungal therapy for pulmonary aspergilloma.
Topics: Aged; Antifungal Agents; Aspergillosis; Drug Interactions; Follow-Up Studies; Hallucinations; Heart Failure; Humans; Itraconazole; Liver Function Tests; Lung Diseases, Fungal; Male; Pyrimidines; Triazoles; Voriconazole | 2008 |
Posaconazole efficacy in a murine disseminated infection caused by Paecilomyces lilacinus.
Topics: Amphotericin B; Animals; Antifungal Agents; Colony Count, Microbial; Kidney; Liver; Male; Mice; Mycoses; Paecilomyces; Spleen; Triazoles | 2009 |
Clinical experience with posaconazole in patients with invasive mucormycosis: a case series.
Topics: Adult; Antifungal Agents; Humans; Male; Middle Aged; Mucormycosis; Triazoles | 2008 |
Multiple-azole-resistant Aspergillus fumigatus osteomyelitis in a patient with chronic granulomatous disease successfully treated with long-term oral posaconazole and surgery.
Topics: Administration, Oral; Adolescent; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Azoles; Drug Resistance, Fungal; Foot Bones; Granulomatous Disease, Chronic; Humans; Male; Osteomyelitis; Radiography; Treatment Outcome; Triazoles | 2009 |
Voriconazole and posaconazole resistant Candida pelliculosa fungemia after cardiac surgery.
Topics: Amphotericin B; Antifungal Agents; Candida; Cardiac Surgical Procedures; Child; Drug Resistance, Multiple, Fungal; Fungemia; Humans; Infant; Postoperative Complications; Pyrimidines; Triazoles; Voriconazole | 2009 |
Antifungal susceptibility testing of Exophiala spp.: a head-to-head comparison of amphotericin B, itraconazole, posaconazole and voriconazole.
Topics: Amphotericin B; Antifungal Agents; Exophiala; Humans; Itraconazole; Microbial Sensitivity Tests; Mycoses; Pyrimidines; Triazoles; Voriconazole | 2009 |
Treatment of intestinal and hepatic mucormycosis in an immunocompromized child.
Topics: Antifungal Agents; Antineoplastic Agents, Phytogenic; Child, Preschool; Drug Therapy, Combination; Humans; Immunocompromised Host; Intestinal Diseases; Liver Diseases; Magnetic Resonance Imaging; Male; Mucormycosis; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Tomography, X-Ray Computed; Triazoles; Vincristine | 2009 |
Triazole-resistant candidaemia following posaconazole exposure.
Topics: Adult; Antifungal Agents; Candida; Candidiasis; Drug Resistance, Fungal; Female; Fungemia; Humans; Male; Microbial Sensitivity Tests; Triazoles; Young Adult | 2009 |
Mucor circinelloides as a cause of invasive maxillofacial zygomycosis: an emerging dimorphic pathogen with reduced susceptibility to posaconazole.
Topics: Adult; Amphotericin B; Antifungal Agents; DNA, Fungal; Drug Resistance, Fungal; Humans; Male; Maxillary Diseases; Molecular Sequence Data; Mucor; Sequence Analysis, DNA; Triazoles; Zygomycosis | 2009 |
Activity of posaconazole and other antifungal agents against Mucorales strains identified by sequencing of internal transcribed spacers.
Topics: Amphotericin B; Antifungal Agents; DNA, Ribosomal Spacer; Microbial Sensitivity Tests; Mucorales; Triazoles | 2009 |
Comparative in vitro activities of posaconazole, voriconazole, itraconazole, and amphotericin B against Aspergillus and Rhizopus, and synergy testing for Rhizopus.
Topics: Amphotericin B; Antifungal Agents; Aspergillosis; Aspergillus; Drug Synergism; Humans; Itraconazole; Microbial Sensitivity Tests; Mucormycosis; Pyrimidines; Rhizopus; Triazoles; Voriconazole | 2008 |
[Invasive pulmonary mucormycosis with invasion of the thoracic spine in a patient with myelodysplastic syndrome].
Topics: Aged; Amphotericin B; Antifungal Agents; Drug Therapy, Combination; Fatal Outcome; Humans; Immunocompromised Host; Laminectomy; Lung Diseases, Fungal; Male; Mucormycosis; Myelodysplastic Syndromes; Spinal Diseases; Thoracic Vertebrae; Triazoles | 2008 |
An increasing trend of cutaneous zygomycosis caused by Mycocladus corymbifer (formerly Absidia corymbifera): report of two cases and review of primary cutaneous Mycocladus infections.
Topics: Absidia; Adult; Amphotericin B; Antifungal Agents; Debridement; Dermatomycoses; Foot; Humans; Leg; Male; Triazoles; Zygomycosis | 2009 |
Interactions between triazoles and amphotericin B in treatment of disseminated murine infection by Fusarium oxysporum.
Topics: Amphotericin B; Animals; Antifungal Agents; Drug Therapy, Combination; Fusarium; Male; Mice; Mycoses; Pyrimidines; Triazoles; Voriconazole | 2009 |
Efficacy of combined surgery and antifungal therapies for the management of invasive zygomycoses in patients with haematological malignancies.
Topics: Aged; Amphotericin B; Antifungal Agents; Hematologic Neoplasms; Humans; Immunocompromised Host; Male; Middle Aged; Treatment Outcome; Triazoles; Zygomycosis | 2010 |
Successful treatment of pulmonary zygomycosis in two transplant recipients with liposomal amphotericin B and partial surgical resection followed by posaconazole.
Topics: Adult; Amphotericin B; Antifungal Agents; Debridement; Histocytochemistry; Humans; Lung; Lung Diseases, Fungal; Male; Microscopy; Middle Aged; Radiography, Thoracic; Tomography; Transplantation; Treatment Outcome; Triazoles; Zygomycosis | 2010 |
Limited penetration of posaconazole into cerebrospinal fluid in an allogeneic stem cell recipient with invasive pulmonary aspergillosis.
Topics: Acute Disease; Antifungal Agents; Aspergillosis; Central Nervous System Fungal Infections; Hematopoietic Stem Cell Transplantation; Humans; Leukemia, Myeloid; Lung Diseases, Fungal; Male; Triazoles; Young Adult | 2009 |
Omeprazole significantly reduces posaconazole serum trough level.
Topics: Drug Interactions; Humans; Omeprazole; Serum; Triazoles | 2009 |
Posaconazole therapeutic drug monitoring: a reference laboratory experience.
Topics: Antifungal Agents; Chemoprevention; Chromatography, High Pressure Liquid; Drug Monitoring; Humans; Laboratories; Mycoses; Reference Standards; Texas; Triazoles | 2009 |
Antifungal activity of amphotericin B, caspofungin and posaconazole on Candida albicans biofilms in intermediate and mature development phases.
Topics: Amphotericin B; Antifungal Agents; Biofilms; Candida albicans; Caspofungin; Colony Count, Microbial; Echinocandins; Humans; Lipopeptides; Microbial Sensitivity Tests; Microbial Viability; Triazoles | 2010 |
A routine method for the quantification of the novel antimycotic drug posaconazole in plasma using liquid chromatography-tandem mass spectrometry.
Topics: Antifungal Agents; Calibration; Chromatography, Liquid; Humans; Reproducibility of Results; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Triazoles | 2009 |
A comparison of the fungicidal activity of amphotericin B and posaconazole against Zygomycetes in vitro.
Topics: Amphotericin B; Animals; Antifungal Agents; Humans; Microbial Sensitivity Tests; Microbial Viability; Mucor; Rhizopus; Time Factors; Triazoles; Zygomycosis | 2009 |
Posaconazole for bone-invading rhinomaxillary mucormycosis.
Topics: Aged, 80 and over; Antifungal Agents; Female; Humans; Maxillary Diseases; Mucormycosis; Paranasal Sinus Diseases; Triazoles | 2009 |
[Amphotericin and posaconazole for gastrointestinal mucormycosis].
Topics: Acinetobacter baumannii; Acinetobacter Infections; Adult; Amphotericin B; Anti-Bacterial Agents; Antifungal Agents; Arthritis, Rheumatoid; Colitis, Ulcerative; Combined Modality Therapy; Drainage; Fatal Outcome; Gastrointestinal Diseases; Humans; Ileal Diseases; Intestinal Perforation; Intraoperative Complications; Jejunal Diseases; Liposomes; Male; Mucormycosis; Peritonitis; Postoperative Complications; Shock, Septic; Triazoles | 2009 |
Posaconazole-increased vincristine neurotoxicity in a child: a case report.
Topics: Antifungal Agents; Antineoplastic Agents, Phytogenic; Child; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Female; Humans; Mycoses; Nervous System Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Triazoles; Vincristine | 2009 |
Safe management of tacrolimus together with posaconazole in lung transplant patients with cystic fibrosis.
Topics: Adult; Antifungal Agents; Aspergillosis; Candidiasis; Cystic Fibrosis; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Drug Monitoring; Drug-Related Side Effects and Adverse Reactions; Enzyme Inhibitors; Female; Graft Rejection; Humans; Immunosuppressive Agents; Itraconazole; Lung Transplantation; Male; Microbial Sensitivity Tests; Mycoses; Prescriptions; Pyrimidines; Tacrolimus; Triazoles; Voriconazole | 2009 |
Evaluating the resistance to posaconazole by E-test and CLSI broth microdilution methodologies of Candida spp. and pathogenic moulds.
Topics: Antifungal Agents; Candida; Fungi; Humans; Microbial Sensitivity Tests; Mycoses; Triazoles | 2009 |
Simultaneous determination of voriconazole and posaconazole concentrations in human plasma by high-performance liquid chromatography.
Topics: Antifungal Agents; Chromatography, High Pressure Liquid; Humans; Pyrimidines; Reproducibility of Results; Triazoles; Voriconazole | 2009 |
Dynamics of in vitro acquisition of resistance by Candida parapsilosis to different azoles.
Topics: Antifungal Agents; Biosynthetic Pathways; Candida; Drug Resistance, Fungal; Ergosterol; Fluconazole; Humans; Microbial Sensitivity Tests; Mutation; Pyrimidines; Triazoles; Voriconazole | 2009 |
Cutaneous infection caused by Macrophomina phaseolina in a child with acute myeloid leukemia.
Topics: Antifungal Agents; Ascomycota; Child; Dermatomycoses; DNA, Fungal; DNA, Ribosomal Spacer; Female; Humans; Immunocompromised Host; Leukemia, Myeloid, Acute; Molecular Sequence Data; Sequence Analysis, DNA; Skin; Triazoles | 2009 |
A high-throughput LC-MS/MS method for the quantitation of posaconazole in human plasma: Implementing fused core silica liquid chromatography.
Topics: Antifungal Agents; Chromatography, Liquid; Humans; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Triazoles | 2009 |
In vitro interactions between antifungals and immunosuppressive drugs against zygomycetes.
Topics: Amphotericin B; Antifungal Agents; Azoles; Cyclosporine; Drug Interactions; Immunosuppressive Agents; Itraconazole; Microbial Sensitivity Tests; Mucorales; Rhizopus; Sirolimus; Tacrolimus; Thiazoles; Triazoles | 2009 |
Rhinocerebral mucormycosis.
Topics: Aged; Antifungal Agents; Brain Diseases; Diabetes Complications; Fatal Outcome; Female; Humans; Mucormycosis; Nose Diseases; Triazoles | 2009 |
[Painful peripheral neuropathy associated with voriconazole during the treatment of chronic cavitary pulmonary aspergillosis].
Topics: Aged; Antifungal Agents; Aspergillosis, Allergic Bronchopulmonary; Chronic Disease; Humans; Male; Pain; Peripheral Nervous System Diseases; Pyrimidines; Treatment Outcome; Triazoles; Voriconazole | 2010 |
Efficacy of triazoles in a murine disseminated infection by Candida krusei.
Topics: Amphotericin B; Animals; Antifungal Agents; Candida; Candidiasis; Kidney; Male; Mice; Pyrimidines; Random Allocation; Triazoles; Voriconazole | 2009 |
Management of metabolic cytochrome P450 3A4 drug-drug interaction between everolimus and azole antifungals in a renal transplant patient.
Topics: Antifungal Agents; Aspergillosis; Cytochrome P-450 CYP3A; Drug Interactions; Drug Monitoring; Everolimus; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Pyrimidines; Sirolimus; Triazoles; Voriconazole | 2009 |
Splenic hyalohyphomycosis, molecularly and immunologically consistent with invasive aspergillosis, in a patient with acute lymphoblastic leukemia.
Topics: Acute Disease; Amphotericin B; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Aspergillosis; Aspergillus; Caspofungin; Combined Modality Therapy; Echinocandins; Humans; Hyphae; Immunocompromised Host; Invasive Pulmonary Aspergillosis; Leukemia, B-Cell; Lipopeptides; Male; Middle Aged; Neutropenia; Spleen; Splenectomy; Splenic Diseases; Triazoles | 2010 |
Determination of the antifungal agent posaconazole in human serum by HPLC with parallel column-switching technique.
Topics: Antifungal Agents; Chromatography, High Pressure Liquid; Humans; Sensitivity and Specificity; Triazoles | 2009 |
Simultaneous determination of five systemic azoles in plasma by high-performance liquid chromatography with ultraviolet detection.
Topics: Calibration; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Drug Monitoring; Drug Stability; Fluconazole; Humans; Itraconazole; Ketoconazole; Pyrimidines; Quality Control; Reproducibility of Results; Spectrophotometry, Ultraviolet; Time Factors; Triazoles; Ultraviolet Rays; Voriconazole | 2009 |
What should be the first-choice strategy to maximize posaconazole exposure in daily clinical practice?
Topics: Administration, Oral; Antifungal Agents; Area Under Curve; Drug Administration Schedule; Food-Drug Interactions; Gastric Mucosa; Humans; Mycoses; Triazoles | 2009 |
Posaconazole-induced topiramate toxicity.
Topics: Anorexia; Anticonvulsants; Antifungal Agents; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Disorders of Excessive Somnolence; Drug Interactions; Fructose; Humans; Male; Middle Aged; Stupor; Topiramate; Triazoles | 2009 |
Atypical Aspergillus flavus isolates associated with chronic azole therapy.
Topics: Antifungal Agents; Aspergillosis; Aspergillus flavus; Azoles; Female; Humans; Itraconazole; Middle Aged; Pyrimidines; Sinusitis; Triazoles; Voriconazole | 2009 |
Azole resistance in allergic bronchopulmonary aspergillosis and Aspergillus bronchitis.
Topics: Adult; Amino Acid Substitution; Antifungal Agents; Aspergillosis, Allergic Bronchopulmonary; Aspergillus fumigatus; Azoles; Bronchitis; Cytochrome P-450 Enzyme System; Drug Resistance, Fungal; Female; Fungal Proteins; Humans; Itraconazole; Middle Aged; Mutation, Missense; Plasma; Pyrimidines; Triazoles; Voriconazole | 2010 |
Cutaneous zygomycosis caused by Saksenaea vasiformis following water-related wound in a 24-year-old immunocompetent woman.
Topics: Amphotericin B; Antifungal Agents; Debridement; Dermatomycoses; Female; Histocytochemistry; Humans; Mucorales; Skin; Triazoles; Wound Infection; Young Adult; Zygomycosis | 2009 |
Comparison of assessment of oxygen consumption, Etest, and CLSI M38-A2 broth microdilution methods for evaluation of the susceptibility of Aspergillus fumigatus to posaconazole.
Topics: Antifungal Agents; Aspergillus fumigatus; Drug Resistance, Fungal; Microbial Sensitivity Tests; Oxygen Consumption; Triazoles | 2009 |
Posaconazole attenuates leukotriene B4 release and uptake of calcium by chemoattractant-activated human neutrophils: a potential strategy to control neutrophil-mediated inflammation.
Topics: Adult; Anti-Inflammatory Agents; Calcium; Humans; Immunoassay; Immunologic Factors; Leukotriene B4; Neutrophils; Platelet Activating Factor; Spectrometry, Fluorescence; Triazoles; Young Adult | 2009 |
Therapeutic drug monitoring of posaconazole: a monocentric study with 54 adults.
Topics: Adult; Antifungal Agents; Diarrhea; Drug Monitoring; Female; Humans; Male; Middle Aged; Mucositis; Mycoses; Retrospective Studies; Triazoles | 2009 |
Correlation of in vitro activity, serum levels, and in vivo efficacy of posaconazole against Rhizopus microsporus in a murine disseminated infection.
Topics: Amphotericin B; Animals; Antifungal Agents; Brain; Kidney; Male; Mice; Mucormycosis; Rhizopus; Triazoles | 2009 |
Economic evaluation of posaconazole vs fluconazole in the prevention of invasive fungal infections in patients with GVHD following haematopoietic SCT.
Topics: Antifungal Agents; Cost-Benefit Analysis; Fluconazole; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Multivariate Analysis; Mycoses; Sensitivity and Specificity; Treatment Outcome; Triazoles | 2010 |
Therapeutic efficacy of posaconazole against Candida glabrata in a murine model of vaginitis.
Topics: Animals; Antifungal Agents; Candida glabrata; Candidiasis; Disease Models, Animal; Female; Humans; Mice; Mice, Inbred BALB C; Random Allocation; Triazoles; Vaginitis | 2011 |
Phospholipidosis in neurons caused by posaconazole, without evidence for functional neurologic effects.
Topics: Animals; Antifungal Agents; Dogs; Ganglia, Spinal; Lipidoses; Medulla Oblongata; Myenteric Plexus; Nerve Fibers, Myelinated; Neurons; Phospholipids; Thalamus; Toxicity Tests, Chronic; Triazoles | 2009 |
Efficacy of posaconazole in a murine disseminated infection by Candida tropicalis.
Topics: Animals; Antifungal Agents; Body Burden; Candida tropicalis; Candidiasis; Dose-Response Relationship, Drug; Immunosuppression Therapy; Kaplan-Meier Estimate; Male; Mice; Microbial Sensitivity Tests; Survival; Triazoles | 2010 |
Emerging therapeutic options in fulminant invasive rhinocerebral mucormycosis.
Topics: Aged; Antifungal Agents; Central Nervous System Bacterial Infections; Female; Humans; Male; Mucormycosis; Rhinitis; Severity of Illness Index; Triazoles | 2010 |
Factors influencing pharmacokinetics of prophylactic posaconazole in patients undergoing allogeneic stem cell transplantation.
Topics: Adolescent; Adult; Aged; Algorithms; Antifungal Agents; Chromatography, High Pressure Liquid; Cohort Studies; Drug Interactions; Drug Monitoring; Female; Humans; Male; Middle Aged; Models, Statistical; Mycoses; Population; Stem Cell Transplantation; Triazoles; Young Adult | 2010 |
Müeller-Hinton methylene blue media as an alternative to RPMI 1640 for determining the susceptibility of Cryptococcus neoformans and Cryptococcus gattii to posaconazole with Etest.
Topics: Antifungal Agents; Cryptococcus gattii; Cryptococcus neoformans; Culture Media; Humans; Microbial Sensitivity Tests; Triazoles | 2010 |
[Prophylaxis use of posaconazole (P) in an hemato-oncology unit: a retrospective study].
Topics: Adult; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Drug Therapy, Combination; Esomeprazole; Female; Hematopoietic Stem Cell Transplantation; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Mycoses; Myelodysplastic Syndromes; Neutropenia; Oncology Service, Hospital; Postoperative Complications; Premedication; Retrospective Studies; Transplantation Conditioning; Transplantation, Autologous; Treatment Failure; Triazoles | 2010 |
Pharmacokinetics of a single dose of the antifungal posaconazole as oral suspension in subjects with hepatic impairment.
Topics: Administration, Oral; Adult; Antifungal Agents; Female; Humans; Liver; Male; Middle Aged; Triazoles | 2010 |
Efficacy of posaconazole against three clinical Aspergillus fumigatus isolates with mutations in the cyp51A gene.
Topics: Administration, Oral; Animals; Antifungal Agents; Area Under Curve; Aspergillosis; Aspergillus fumigatus; Cytochrome P-450 Enzyme System; Disease Models, Animal; Drug Administration Schedule; Female; Fungal Proteins; Mice; Microbial Sensitivity Tests; Mutation; Triazoles | 2010 |
[Non-fatal disseminated mucormycosis in a solid organ transplant].
Topics: Absidia; Adult; Amphotericin B; Antifungal Agents; Combined Modality Therapy; Debridement; Female; Humans; Lung Diseases, Fungal; Lung Transplantation; Mucormycosis; Opportunistic Infections; Thyroid Diseases; Triazoles | 2009 |
Breakthrough zygomycosis on posaconazole prophylaxis after allogeneic stem cell transplantation.
Topics: Amphotericin B; Antifungal Agents; Chemoprevention; Drug Therapy, Combination; Fatal Outcome; Graft vs Host Disease; Humans; Lung Diseases, Fungal; Male; Middle Aged; Mucormycosis; Pneumonia; Rhizopus; Stem Cell Transplantation; Transplantation, Homologous; Triazoles | 2010 |
In vitro activity of antifungal combinations against Candida albicans biofilms.
Topics: Amphotericin B; Antifungal Agents; Austria; Biofilms; Candida albicans; Candidiasis; Caspofungin; Drug Synergism; Echinocandins; Fungemia; Humans; Intensive Care Units; Lipopeptides; Microbial Sensitivity Tests; Triazoles | 2010 |
Successful treatment of ascending aortic graft and valve endocarditis after debulking splenectomy for invasive aspergillosis and mucor.
Topics: Aneurysm; Antifungal Agents; Aortic Aneurysm, Thoracic; Arterial Occlusive Diseases; Aspergillosis; Blood Vessel Prosthesis; Endocarditis; Femoral Artery; Heart Valve Prosthesis; Humans; Male; Middle Aged; Mucormycosis; Popliteal Artery; Prosthesis-Related Infections; Splenectomy; Triazoles | 2009 |
Unusual presentation of chromoblastomycosis due to Cladophialophora carrionii in a renal and pancreas transplant recipient patient successfully treated with posaconazole and surgical excision.
Topics: Antifungal Agents; Ascomycota; Chromoblastomycosis; Humans; Immunocompromised Host; Kidney Transplantation; Male; Middle Aged; Pancreas Transplantation; Treatment Outcome; Triazoles | 2010 |
Evaluation of antifungal therapy in a neutropenic murine model of Neoscytalidium dimidiatum infection.
Topics: Amphotericin B; Animals; Antifungal Agents; Ascomycota; Colony Count, Microbial; Disease Models, Animal; Kidney; Male; Mice; Mycoses; Neutropenia; Pyrimidines; Sepsis; Spleen; Survival Analysis; Treatment Outcome; Triazoles; Voriconazole | 2010 |
Murine model of a disseminated infection by the novel fungus Fonsecaea monophora and successful treatment with posaconazole.
Topics: Animals; Antifungal Agents; Ascomycota; Brain; Disease Models, Animal; Kidney; Liver; Lung; Male; Mice; Mycoses; Triazoles | 2010 |
Efficacy of posaconazole as treatment and prophylaxis against Fusarium solani.
Topics: Animals; Antifungal Agents; Chemoprevention; Disease Models, Animal; Drug Resistance, Fungal; Fusarium; Humans; Kidney; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Mycoses; Neutropenia; Treatment Outcome; Triazoles | 2010 |
In vitro activities of eight antifungal drugs against 55 clinical isolates of Fonsecaea spp.
Topics: Amphotericin B; Anidulafungin; Antifungal Agents; Ascomycota; Caspofungin; Chromoblastomycosis; Drug Resistance, Fungal; Echinocandins; Fluconazole; Humans; In Vitro Techniques; Itraconazole; Lipopeptides; Microbial Sensitivity Tests; Nitriles; Pyridines; Pyrimidines; Triazoles; Voriconazole | 2010 |
Current controversies in treating invasive zygomycosis.
Topics: Amphotericin B; Antifungal Agents; Cunninghamella; Drug Therapy, Combination; Humans; Lung Diseases, Fungal; Mucormycosis; Pyrimidines; Triazoles; Voriconazole | 2010 |
Successful triple combination therapy of disseminated absidia corymbifera infection in an adolescent with osteosarcoma.
Topics: Absidia; Adolescent; Amphotericin B; Antineoplastic Agents; Caspofungin; Drug Therapy, Combination; Echinocandins; Female; Femoral Neoplasms; Humans; Lipopeptides; Mucormycosis; Opportunistic Infections; Osteosarcoma; Triazoles | 2010 |
Cunninghamella bertholletiae exhibits increased resistance to human neutrophils with or without antifungal agents as compared to Rhizopus spp.
Topics: Adult; Antifungal Agents; Caspofungin; Cells, Cultured; Cunninghamella; Echinocandins; Enzyme-Linked Immunosorbent Assay; Humans; Interleukin-6; Interleukin-8; Lipopeptides; Microbial Viability; Neutrophils; Pyrimidines; Rhizopus; Tetrazolium Salts; Triazoles; Tumor Necrosis Factor-alpha; Voriconazole | 2010 |
Report of a successful treatment of pulmonary Cunninghamella bertholletiae infection with liposomal amphotericin and posaconazole in a child with GvHD and review of the literature.
Topics: Amphotericin B; Bone Marrow Transplantation; Child; Cunninghamella; Drug Therapy, Combination; Female; Graft vs Host Disease; Humans; Lung Diseases, Fungal; Mucormycosis; Triazoles | 2010 |
In vitro interaction of posaconazole with calcineurin inhibitors and sirolimus against zygomycetes.
Topics: Antifungal Agents; Calcineurin; Cyclosporine; Drug Interactions; Humans; Mucorales; Sirolimus; Tacrolimus; Triazoles | 2010 |
Drug costs and utilization after implementation of a posaconazole prophylaxis protocol in adults with acute myelogenous leukemia.
Topics: Anti-Bacterial Agents; Antifungal Agents; Antineoplastic Agents; Drug Costs; Drug Utilization; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Mycoses; Pharmacy Service, Hospital; Retrospective Studies; Triazoles | 2010 |
Malignant thymoma with immunodeficiency (Good syndrome) associated with mucormycosis.
Topics: Abdominal Abscess; Agammaglobulinemia; Aged; Antifungal Agents; Humans; Male; Mucormycosis; Thymoma; Thymus Neoplasms; Triazoles | 2010 |
Correlation between in vitro activity of posaconazole and in vivo efficacy against Rhizopus oryzae infection in mice.
Topics: Animals; Antifungal Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance, Fungal; In Vitro Techniques; Kaplan-Meier Estimate; Kidney; Mice; Mucormycosis; Rhizopus; Triazoles | 2010 |
Cutaneous model of invasive aspergillosis.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Catalase; Cyclophosphamide; Dermatomycoses; Disease Models, Animal; Female; Galactose; Hyphae; Immunocompromised Host; Immunosuppressive Agents; Mannans; Mice; Mice, Inbred BALB C; Mice, Nude; Mutagenesis; Skin; Spores; Triazoles; Virulence; Virulence Factors | 2010 |
Disseminated Rhizopus microsporus infection cured by salvage allogeneic hematopoietic stem cell transplantation, antifungal combination therapy, and surgical resection.
Topics: Amphotericin B; Antifungal Agents; Drug Therapy, Combination; Female; Hematopoietic Stem Cell Transplantation; Humans; Leukemia, Myeloid, Acute; Middle Aged; Mucormycosis; Rhizopus; Salvage Therapy; Transplantation, Homologous; Treatment Outcome; Triazoles | 2010 |
Rifampin and posaconazole coadministration leads to decreased serum posaconazole concentrations.
Topics: Antifungal Agents; Drug Interactions; Humans; Male; Rifampin; Serum; Triazoles; Young Adult | 2010 |
Use of a high-resolution melt assay to characterize codon 54 of the cyp51A gene of Aspergillus fumigatus on a Rotor-Gene 6000 instrument.
Topics: Antifungal Agents; Aspergillus fumigatus; Codon; Cytochrome P-450 Enzyme System; Drug Resistance, Fungal; Fungal Proteins; Genes, Fungal; Genetic Testing; Glycine; Itraconazole; Microbial Sensitivity Tests; Nucleic Acid Denaturation; Sequence Analysis, DNA; Triazoles | 2010 |
Severe life threatening neurotoxicity in a child with acute lymphoblastic leukemia receiving posaconazole and vincristine.
Topics: Antifungal Agents; Antineoplastic Agents, Phytogenic; Child, Preschool; Drug Interactions; Drug Therapy, Combination; Humans; Male; Mucormycosis; Neurotoxicity Syndromes; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Triazoles; Vincristine | 2010 |
Pharmacoeconomic evaluation of voriconazole versus posaconazole for antifungal prophylaxis in acute myeloid leukaemia.
Topics: Adult; Aged; Aged, 80 and over; Antifungal Agents; Australia; Chemoprevention; Cost-Benefit Analysis; Female; Hospitals; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Mycoses; Pyrimidines; Retrospective Studies; Treatment Outcome; Triazoles; Voriconazole | 2010 |
Posaconazole prophylaxis during induction therapy of patients with acute lymphoblastic leukaemia.
Topics: Adult; Alanine Transaminase; Antifungal Agents; Aspartate Aminotransferases; Aspergillus; Bilirubin; Candida; Chemical and Drug Induced Liver Injury; Chemoprevention; Female; Humans; Liver Function Tests; Male; Mycoses; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Triazoles; Young Adult | 2011 |
Successful treatment with posaconazole of a patient with chronic Chagas disease and systemic lupus erythematosus.
Topics: Adult; Chagas Disease; Female; Humans; Lupus Erythematosus, Systemic; Triazoles; Trypanocidal Agents | 2010 |
A noninvasive renal fungus ball caused by Rhizopus--a previously unreported manifestation of zygomycosis.
Topics: Adult; Amphotericin B; Antifungal Agents; Humans; Kidney Diseases; Kidney Pelvis; Male; Mucormycosis; Renal Insufficiency; Rhizopus; Triazoles; Ureter | 2010 |
Structural characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei bound to the antifungal drugs posaconazole and fluconazole.
Topics: Amino Acid Sequence; Antifungal Agents; Crystallography, X-Ray; Cytochrome P-450 Enzyme System; Fluconazole; Models, Molecular; Molecular Sequence Data; Protein Binding; Protein Structure, Tertiary; Sequence Alignment; Triazoles; Trypanosoma brucei brucei; Trypanosoma cruzi | 2010 |
Use of posaconazole in the treatment of infective rhinocerebral mucormycosis.
Topics: Antifungal Agents; Brain Diseases; Diabetes Mellitus, Type 2; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Mucormycosis; Orbital Diseases; Paranasal Sinus Diseases; Rhizopus; Triazoles | 2010 |
Clinical effectiveness of posaconazole prophylaxis in patients with acute myelogenous leukaemia (AML): a 6 year experience of the Cologne AML cohort.
Topics: Adolescent; Adult; Aged; Antifungal Agents; Chemoprevention; Female; Germany; Humans; Incidence; Length of Stay; Leukemia, Myeloid, Acute; Male; Middle Aged; Mycoses; Polyenes; Retrospective Studies; Treatment Outcome; Triazoles; Young Adult | 2010 |
Cost-effectiveness of posaconazole compared with standard azole therapy for prevention of invasive fungal infections in patients at high risk in Switzerland.
Topics: Cost-Benefit Analysis; Decision Support Techniques; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Leukemia, Myeloid, Acute; Markov Chains; Models, Theoretical; Mycoses; Myelodysplastic Syndromes; Neutropenia; Risk; Switzerland; Treatment Outcome; Triazoles | 2010 |
Antifungal susceptibility profile of human-pathogenic species of Lichtheimia.
Topics: Amphotericin B; Antifungal Agents; Humans; Microbial Sensitivity Tests; Mucorales; Pyrimidines; Triazoles; Voriconazole | 2010 |
Presumed Scopulariopsis brevicaulis chorioretinitis in a stem cell transplant recipient.
Topics: Adult; Antifungal Agents; Ascomycota; Chorioretinitis; Fluorescein Angiography; Humans; Macula Lutea; Male; Mitosporic Fungi; Onychomycosis; Stem Cell Transplantation; Triazoles | 2010 |
[Exophytic and ulcerative lesions on the lower limb in a Moroccan patient].
Topics: Antifungal Agents; Ascomycota; Combined Modality Therapy; Debridement; Dermatomycoses; Humans; Itraconazole; Leg Ulcer; Male; Middle Aged; Mitosporic Fungi; Morocco; Triazoles | 2011 |
A comparative study of posaconazole and benznidazole in the prevention of heart damage and promotion of trypanocidal immune response in a murine model of Chagas disease.
Topics: Animals; Antiprotozoal Agents; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chagas Cardiomyopathy; Chagas Disease; Disease Models, Animal; Female; Heart; Humans; Mice; Myocardium; Nitroimidazoles; Survival Analysis; Triazoles; Trypanosoma cruzi | 2010 |
AfMkk2 is required for cell wall integrity signaling, adhesion, and full virulence of the human pathogen Aspergillus fumigatus.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Cell Adhesion; Cell Wall; Disease Models, Animal; Glass; Humans; Hydrogen-Ion Concentration; Mice; Mitogen-Activated Protein Kinase Kinases; Plastics; Pyrimidines; Signal Transduction; Survival Analysis; Temperature; Triazoles; Virulence; Virulence Factors; Voriconazole | 2010 |
Antifungal therapies in murine disseminated phaeohyphomycoses caused by Exophiala species.
Topics: Administration, Oral; Amphotericin B; Animals; Antifungal Agents; Exophiala; Injections, Intraperitoneal; Itraconazole; Male; Mice; Mycoses; Treatment Outcome; Triazoles | 2010 |
Posaconazole salvage treatment in paediatric patients: a multicentre survey.
Topics: Adolescent; Antifungal Agents; Child; Child, Preschool; Female; Humans; Male; Mycoses; Salvage Therapy; Time Factors; Treatment Outcome; Triazoles | 2010 |
Rhizopus oryzae skin infection treated with posaconazole in a boy with chronic granulomatous disease.
Topics: Antifungal Agents; Child, Preschool; Dermatomycoses; Granulomatous Disease, Chronic; Humans; Male; Mucormycosis; Rhizopus; Triazoles | 2010 |
Mucormycosis may mimic disease relapse in Wegener's granulomatosis.
Topics: Adult; Amphotericin B; Antifungal Agents; Diagnosis, Differential; Drug Therapy, Combination; Granulomatosis with Polyangiitis; Humans; Immunocompromised Host; Male; Mucormycosis; Radiography, Thoracic; Recurrence; Treatment Outcome; Triazoles | 2010 |
Steady-state intrapulmonary pharmacokinetics and pharmacodynamics of posaconazole in lung transplant recipients.
Topics: Adult; Aged; Chromatography, Liquid; Epithelium; Female; Humans; Lung; Lung Transplantation; Male; Microbial Sensitivity Tests; Middle Aged; Prospective Studies; Pulmonary Alveoli; Tandem Mass Spectrometry; Triazoles | 2010 |
Development, validation, and routine application of a high-performance liquid chromatography method coupled with a single mass detector for quantification of itraconazole, voriconazole, and posaconazole in human plasma.
Topics: Antifungal Agents; Calibration; Chromatography, High Pressure Liquid; Humans; Itraconazole; Mass Spectrometry; Pyrimidines; Reference Standards; Triazoles; Voriconazole | 2010 |
Structural insights into inhibition of sterol 14alpha-demethylase in the human pathogen Trypanosoma cruzi.
Topics: Animals; Antifungal Agents; Chagas Disease; Crystallography, X-Ray; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Immunoblotting; Molecular Structure; Myocytes, Cardiac; Protein Structure, Secondary; Triazoles; Trypanosoma cruzi | 2010 |
Therapeutic drug monitoring of posaconazole in hematology patients: experience with a new high-performance liquid chromatography-based method.
Topics: Adult; Aged; Antifungal Agents; Chromatography, High Pressure Liquid; Female; Hematologic Neoplasms; Humans; Male; Middle Aged; Mycoses; Prospective Studies; Triazoles | 2010 |
Experimental murine scedosporiosis: histopathology and azole treatment.
Topics: Amphotericin B; Animals; Antifungal Agents; Azoles; Brain; Kidney; Mice; Mycetoma; Pyrimidines; Scedosporium; Spleen; Treatment Outcome; Triazoles; Voriconazole | 2010 |
In vitro susceptibility of filamentous fungi to itraconazole, voriconazole and posaconazole by Clinical and Laboratory Standards Institute reference method and E-test.
Topics: Antifungal Agents; Fungi; Humans; Itraconazole; Microbial Sensitivity Tests; Mycoses; Pyrimidines; Triazoles; Voriconazole | 2011 |
In vitro antifungal activities of isavuconazole and comparators against rare yeast pathogens.
Topics: Antifungal Agents; Dipodascus; Fluconazole; Microbial Sensitivity Tests; Nitriles; Pyridines; Pyrimidines; Rhodotorula; Saccharomyces cerevisiae; Triazoles; Trichosporon; Voriconazole | 2010 |
Chagas disease: pushing through the pipeline.
Topics: Adult; Animals; Chagas Disease; Child; Chronic Disease; Clinical Trials as Topic; Drug Evaluation, Preclinical; Female; Humans; Infant, Newborn; Lupus Erythematosus, Systemic; Molecular Targeted Therapy; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2010 |
Wild-type MIC distributions and epidemiological cutoff values for the triazoles and six Aspergillus spp. for the CLSI broth microdilution method (M38-A2 document).
Topics: Antifungal Agents; Aspergillosis; Aspergillus; Europe; Humans; Itraconazole; Microbial Sensitivity Tests; Pyrimidines; Triazoles; United States; Voriconazole | 2010 |
Aspergillus endocarditis 2003-2009.
Topics: Adolescent; Adult; Aged; Amphotericin B; Antifungal Agents; Aspergillosis; Aspergillus; Child; Child, Preschool; Endocarditis; Humans; Immunocompromised Host; Infant; Male; Middle Aged; Pyrimidines; Retrospective Studies; Surgical Procedures, Operative; Triazoles; Voriconazole; Young Adult | 2011 |
Antifungal therapy in a murine model of disseminated infection by Cryptococcus gattii.
Topics: Amphotericin B; Animals; Antifungal Agents; Cryptococcosis; Cryptococcus gattii; Male; Mice; Pyrimidines; Triazoles; Voriconazole | 2010 |
Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.
Topics: Amino Acid Sequence; Aspergillus fumigatus; Azoles; Clotrimazole; Drug Resistance, Multiple, Fungal; Fluconazole; Fungal Proteins; Isoenzymes; Itraconazole; Lanosterol; Molecular Sequence Data; Protein Binding; Pyrimidines; Sequence Homology, Amino Acid; Sterol 14-Demethylase; Substrate Specificity; Triazoles; Voriconazole | 2010 |
European guidelines for antifungal management in leukemia and hematopoietic stem cell transplant recipients: summary of the ECIL 3--2009 update.
Topics: Antifungal Agents; Aspergillosis; Candidiasis; Caspofungin; Echinocandins; Hematopoietic Stem Cell Transplantation; Humans; Immunocompromised Host; Leukemia; Lipopeptides; Micafungin; Mycoses; Neutropenia; Opportunistic Infections; Pyrimidines; Triazoles; Voriconazole | 2011 |
Two new species of Mucor from clinical samples.
Topics: Amphotericin B; Antifungal Agents; DNA, Fungal; DNA, Ribosomal; DNA, Ribosomal Spacer; Humans; Itraconazole; Microbial Sensitivity Tests; Molecular Sequence Data; Mucorales; Mucormycosis; Mycological Typing Techniques; Phylogeny; Sequence Analysis, DNA; Temperature; Triazoles; United States | 2011 |
In vitro and in vivo activities of posaconazole against zygomycetes with various degrees of susceptibility.
Topics: Amphotericin B; Animals; Antifungal Agents; Child; Disease Models, Animal; Humans; Male; Mice; Microbial Sensitivity Tests; Microbial Viability; Mucorales; Rhizopus; Survival Analysis; Tetrazolium Salts; Treatment Outcome; Triazoles; Zygomycosis | 2010 |
Clinical efficacy and safety of primary antifungal prophylaxis with posaconazole vs itraconazole in allogeneic blood and marrow transplantation.
Topics: Adult; Aged; Antifungal Agents; Bone Marrow Transplantation; Disease-Free Survival; Female; Humans; Itraconazole; Male; Middle Aged; Mycoses; Triazoles | 2011 |
Impact of glucuronide interferences on therapeutic drug monitoring of posaconazole by tandem mass spectrometry.
Topics: Antifungal Agents; Drug Monitoring; Glucuronides; Humans; Observer Variation; Tandem Mass Spectrometry; Triazoles | 2010 |
Azole antifungal resistance in Aspergillus fumigatus: 2008 and 2009.
Topics: Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Azoles; Cytochrome P-450 Enzyme System; DNA, Fungal; Drug Resistance, Fungal; Fungal Proteins; Humans; Itraconazole; Microbial Sensitivity Tests; Pyrimidines; Sequence Analysis, DNA; Triazoles; Voriconazole | 2010 |
Complementation of a Saccharomyces cerevisiae ERG11/CYP51 (sterol 14α-demethylase) doxycycline-regulated mutant and screening of the azole sensitivity of Aspergillus fumigatus isoenzymes CYP51A and CYP51B.
Topics: Anti-Bacterial Agents; Aspergillus fumigatus; Azoles; Clotrimazole; Cytochrome P-450 Enzyme System; Doxycycline; Ergosterol; Fluconazole; Fungal Proteins; Genetic Complementation Test; Itraconazole; Pyrimidines; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Triazoles; Voriconazole | 2010 |
Ulcerated plaque under a ruby ring in an immunosuppressed patient.
Topics: Adenine Nucleotides; Aged; Antineoplastic Agents; Arabinonucleosides; Candida; Candidiasis, Cutaneous; Clofarabine; Cytarabine; Dermatologic Agents; Dermatomycoses; Fusarium; Humans; Immunocompromised Host; Itraconazole; Jewelry; Leukemia, Myeloid, Acute; Male; Pyrimidines; Skin Ulcer; Treatment Outcome; Triazoles; Voriconazole | 2010 |
In vitro and in vivo antifungal susceptibilities of the Mucoralean fungus Cunninghamella.
Topics: Amphotericin B; Animals; Antifungal Agents; Caspofungin; Cunninghamella; Diabetes Mellitus, Experimental; Echinocandins; Itraconazole; Lipopeptides; Male; Mice; Microbial Sensitivity Tests; Mucormycosis; Pyrimidines; Thiazoles; Triazoles; Voriconazole | 2010 |
Environmental study of azole-resistant Aspergillus fumigatus and other aspergilli in Austria, Denmark, and Spain.
Topics: Antifungal Agents; Aspergillus fumigatus; Austria; Azoles; Denmark; Drug Resistance, Fungal; Environmental Microbiology; Itraconazole; Microbial Sensitivity Tests; Pyrimidines; Spain; Triazoles; Voriconazole | 2010 |
Comparative survival and cost of antifungal therapy: posaconazole versus standard antifungals in the treatment of refractory invasive aspergillosis.
Topics: Algorithms; Antifungal Agents; Aspergillosis; Cause of Death; Cost-Benefit Analysis; Disease Progression; Drug Costs; Drug Resistance, Fungal; Humans; Matched-Pair Analysis; Survival Analysis; Triazoles; United States | 2010 |
Sinonasal mucormycosis: case report.
Topics: Administration, Oral; Adult; Amphotericin B; Antifungal Agents; Combined Modality Therapy; Diabetes Complications; Diabetic Ketoacidosis; Endoscopy; Ethmoid Sinusitis; Humans; Infusions, Intravenous; Male; Mucormycosis; Opportunistic Infections; Rhinitis; Tomography, X-Ray Computed; Triazoles | 2010 |
Clinical pharmacodynamics and pharmacokinetics of the antifungal extended-spectrum triazole posaconazole: an overview.
Topics: Antifungal Agents; Area Under Curve; Biological Availability; Drug Interactions; Drug Resistance, Fungal; Fungi; Humans; Triazoles | 2010 |
Antifungal activity of posaconazole against Candida spp. and non-Candida clinical yeasts isolates.
Topics: Antifungal Agents; Candida; Candidiasis; Drug Resistance, Fungal; Humans; Microbial Sensitivity Tests; Mycoses; Triazoles; Yeasts | 2010 |
Combined therapy against murine-disseminated infection by Fusarium verticillioides.
Topics: Amphotericin B; Animals; Antifungal Agents; Drug Therapy, Combination; Fusarium; Mice; Mycoses; Pyrimidines; Survival Rate; Triazoles; Voriconazole | 2011 |
In vitro antifungal susceptibilities and amplified fragment length polymorphism genotyping of a worldwide collection of 350 clinical, veterinary, and environmental Cryptococcus gattii isolates.
Topics: Amphotericin B; Amplified Fragment Length Polymorphism Analysis; Animals; Antifungal Agents; Cryptococcus gattii; Environmental Microbiology; Fluconazole; Flucytosine; Genotype; Humans; Microbial Sensitivity Tests; Nitriles; Pyridines; Pyrimidines; Triazoles; Voriconazole | 2010 |
Multiplex ultra-performance liquid chromatography-tandem mass spectrometry method for simultaneous quantification in human plasma of fluconazole, itraconazole, hydroxyitraconazole, posaconazole, voriconazole, voriconazole-N-oxide, anidulafungin, and caspo
Topics: Anidulafungin; Antifungal Agents; Blood Chemical Analysis; Caspofungin; Chromatography, Liquid; Echinocandins; Humans; Itraconazole; Lipopeptides; Pyrimidines; Tandem Mass Spectrometry; Triazoles; Voriconazole | 2010 |
Ultra-performance liquid chromatography mass spectrometry and sensitive bioassay methods for quantification of posaconazole plasma concentrations after oral dosing.
Topics: Administration, Oral; Biological Assay; Chromatography, Liquid; Humans; Mass Spectrometry; Reproducibility of Results; Tandem Mass Spectrometry; Triazoles | 2010 |
Molecular phylogeny and proposal of two new species of the emerging pathogenic fungus Saksenaea.
Topics: Antifungal Agents; DNA, Fungal; DNA, Ribosomal Spacer; Environmental Microbiology; Fungal Proteins; Humans; Itraconazole; Microbial Sensitivity Tests; Molecular Sequence Data; Mucorales; Mucormycosis; Mycological Typing Techniques; Naphthalenes; Peptide Elongation Factor 1; Phylogeny; Sequence Analysis, DNA; Spores, Fungal; Temperature; Terbinafine; Triazoles | 2010 |
Successful treatment of disseminated mixed invasive fungal infection after hematopoietic stem cell transplantation for severe aplastic anemia.
Topics: Anemia, Aplastic; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Child; Combined Modality Therapy; Hematopoietic Stem Cell Transplantation; Humans; Immunocompromised Host; Immunosuppressive Agents; Male; Mucormycosis; Rhizopus; Triazoles | 2012 |
Posaconazole cerebrospinal concentrations in an HIV-infected patient with brain mucormycosis.
Topics: Africa, Western; AIDS-Related Opportunistic Infections; Antifungal Agents; Brain; CD4 Lymphocyte Count; Central Nervous System Fungal Infections; Cerebrospinal Fluid; HIV Infections; Humans; Inhibitory Concentration 50; Magnetic Resonance Imaging; Mucormycosis; Radiography; Triazoles | 2011 |
Pneumothorax and empyema complicating Scedosporium apiospermum mycetoma: not just a problem in the immunocompromised patients.
Topics: Adult; Antifungal Agents; Empyema; Humans; Lung Diseases, Fungal; Male; Mycetoma; Pneumothorax; Scedosporium; Triazoles | 2011 |
Posaconazole versus fluconazole or itraconazole for prevention of invasive fungal infections in patients undergoing intensive cytotoxic therapy for acute myeloid leukemia or myelodysplasia: a cost effectiveness analysis.
Topics: Antifungal Agents; Antineoplastic Agents; Canada; Cost Savings; Cost-Benefit Analysis; Decision Support Techniques; Fluconazole; Humans; Itraconazole; Leukemia, Myeloid, Acute; Models, Economic; Mycoses; Myelodysplastic Syndromes; Neoplasms; Randomized Controlled Trials as Topic; Triazoles | 2011 |
In vitro susceptibility testing of Aspergillus spp. against voriconazole, itraconazole, posaconazole, amphotericin B and caspofungin.
Topics: Amphotericin B; Antifungal Agents; Aspergillus; Caspofungin; Echinocandins; Itraconazole; Lipopeptides; Microbial Sensitivity Tests; Pyrimidines; Triazoles; Voriconazole | 2010 |
Antifungal activity of posaconazole and granulocyte colony-stimulating factor in the treatment of disseminated zygomycosis (mucormycosis) in a neutropaenic murine model.
Topics: Animal Structures; Animals; Colony Count, Microbial; Disease Models, Animal; Granulocyte Colony-Stimulating Factor; Humans; Male; Mice; Mice, Inbred BALB C; Neutropenia; Rhizopus; Rodent Diseases; Treatment Outcome; Triazoles; Zygomycosis | 2011 |
Posaconazole for chronic pulmonary aspergillosis: the next strategy against the threat of azole-resistant Aspergillus infection.
Topics: Antifungal Agents; Aspergillus; Drug Resistance, Fungal; Humans; Pulmonary Aspergillosis; Treatment Outcome; Triazoles | 2010 |
Efficacy and safety of posaconazole for chronic pulmonary aspergillosis.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Fungal; Antifungal Agents; Aspergillus; Chronic Disease; Female; Humans; Lung; Male; Microbial Sensitivity Tests; Middle Aged; Pulmonary Aspergillosis; Radiography, Thoracic; Retrospective Studies; Serum; Treatment Failure; Treatment Outcome; Triazoles | 2010 |
Sixty-year-old man with slowly expanding nodular plaque on the thigh.
Topics: Antifungal Agents; Ascomycota; Chromoblastomycosis; Humans; Male; Middle Aged; National Institutes of Health (U.S.); Thigh; Triazoles; United States | 2010 |
In vitro activity and in vivo efficacy of posaconazole in treatment of murine infections by different isolates of the Aspergillus terreus complex.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Male; Mice; Microbial Sensitivity Tests; Species Specificity; Treatment Outcome; Triazoles | 2011 |
Retrospective survey on the off-label use of posaconazole in pediatric hematology patients.
Topics: Adolescent; Antifungal Agents; Child; Child, Preschool; Hematologic Diseases; Humans; Mycoses; Off-Label Use; Retrospective Studies; Treatment Outcome; Triazoles | 2011 |
Posaconazole prophylaxis in patients with acute myelogenous leukaemia--results from an observational study.
Topics: Adult; Aged; Antifungal Agents; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Mycoses; Neutropenia; Retrospective Studies; Triazoles | 2011 |
Clinical experience with posaconazole prophylaxis--a retrospective analysis in a haematological unit.
Topics: Adult; Aged; Aged, 80 and over; Antifungal Agents; Female; Graft vs Host Disease; Hematology; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Mycoses; Retrospective Studies; Stem Cell Transplantation; Triazoles; Young Adult | 2011 |
Posaconazole: clinical pharmacokinetics and drug interactions.
Topics: Antifungal Agents; Biological Availability; Drug Interactions; Fungi; Humans; Mycoses; Tissue Distribution; Triazoles | 2011 |
Caspofungin plus posaconazole as salvage therapy of invasive fungal infections in immunocompromised patients.
Topics: Adolescent; Adult; Aged; Antifungal Agents; Aspergillosis; Caspofungin; Drug Therapy, Combination; Echinocandins; Female; Humans; Immunocompromised Host; Lipopeptides; Male; Middle Aged; Retrospective Studies; Salvage Therapy; Triazoles; Young Adult | 2011 |
Posaconazole as part of the antifungal armamentarium in the intensive care unit--case reports from a surgical ICU.
Topics: Aged; Antifungal Agents; Female; Humans; Intensive Care Units; Male; Middle Aged; Mycoses; Postoperative Complications; Triazoles | 2011 |
Low prevalence of resistance to azoles in Aspergillus fumigatus in a French cohort of patients treated for haematological malignancies.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Azoles; Cohort Studies; Cytochrome P-450 Enzyme System; Drug Resistance, Fungal; Female; France; Fungal Proteins; Hematologic Neoplasms; Humans; Itraconazole; Male; Microbial Sensitivity Tests; Middle Aged; Mutation; Pyrimidines; Triazoles; Tubulin; Voriconazole | 2011 |
Managing invasive fungal disease in immunocompromised patients.
Topics: Antibiotic Prophylaxis; Antibodies, Monoclonal; Antifungal Agents; Hematopoietic Stem Cell Transplantation; Humans; Immunocompromised Host; Immunotherapy; Infectious Disease Medicine; Mycoses; Risk Factors; Salvage Therapy; Travel; Triazoles | 2010 |
Wild-type MIC distributions and epidemiological cutoff values for posaconazole and voriconazole and Candida spp. as determined by 24-hour CLSI broth microdilution.
Topics: Antifungal Agents; Candida; Candidiasis; Drug Resistance, Fungal; Humans; Microbial Sensitivity Tests; Pyrimidines; Triazoles; Voriconazole | 2011 |
Cost effectiveness of posaconazole in the prophylaxis of invasive fungal infections in acute leukaemia patients for the French healthcare system.
Topics: Acute Disease; Adult; Aged; Antibiotic Prophylaxis; Antifungal Agents; Cost-Benefit Analysis; Decision Trees; Female; France; Fungi; Humans; Leukemia; Leukemia, Myeloid, Acute; Male; Middle Aged; Mycoses; National Health Programs; Triazoles | 2011 |
Posaconazole serum concentrations among cardiothoracic transplant recipients: factors impacting trough levels and correlation with clinical response to therapy.
Topics: Adult; Aged; Antifungal Agents; Female; Heart Transplantation; Humans; Male; Middle Aged; Triazoles | 2011 |
Successful treatment of chronic mucocutaneous candidiasis caused by azole-resistant Candida albicans with posaconazole.
Topics: Administration, Oral; Adult; Antifungal Agents; Candida albicans; Candidiasis, Chronic Mucocutaneous; Drug Resistance, Fungal; Female; Humans; Treatment Outcome; Triazoles | 2011 |
Comparison of the broth microdilution methods of the European Committee on Antimicrobial Susceptibility Testing and the Clinical and Laboratory Standards Institute for testing itraconazole, posaconazole, and voriconazole against Aspergillus isolates.
Topics: Antifungal Agents; Aspergillus; Humans; Itraconazole; Microbial Sensitivity Tests; Pyrimidines; Triazoles; Voriconazole | 2011 |
Comparison of the broth microdilution (BMD) method of the European Committee on Antimicrobial Susceptibility Testing with the 24-hour CLSI BMD method for testing susceptibility of Candida species to fluconazole, posaconazole, and voriconazole by use of ep
Topics: Antifungal Agents; Candida; Candidiasis; Fluconazole; Humans; Microbial Sensitivity Tests; Pyrimidines; Triazoles; Voriconazole | 2011 |
Posaconazole susceptibility of clinical yeast isolates determined by an agar diffusion and microdilution method.
Topics: Antifungal Agents; Candida; Candidiasis; Drug Resistance, Fungal; Humans; Microbial Sensitivity Tests; Triazoles | 2011 |
A post-marketing evaluation of posaconazole plasma concentrations in neutropenic patients with haematological malignancy receiving posaconazole prophylaxis.
Topics: Administration, Oral; Adult; Aged; Antifungal Agents; Drug Monitoring; Female; Humans; Immunocompromised Host; Leukemia, Myeloid, Acute; Male; Middle Aged; Mycoses; Myelodysplastic Syndromes; Neutropenia; Retrospective Studies; Triazoles | 2011 |
In vitro susceptibility of Madurella mycetomatis to posaconazole and terbinafine.
Topics: Antifungal Agents; Itraconazole; Ketoconazole; Madurella; Microbial Sensitivity Tests; Naphthalenes; Terbinafine; Triazoles | 2011 |
Emergence of disseminated infections due to Geosmithia argillacea in patients with chronic granulomatous disease receiving long-term azole antifungal prophylaxis.
Topics: Abscess; Adolescent; Adult; Antifungal Agents; Azoles; Caspofungin; Chemoprevention; DNA, Fungal; DNA, Ribosomal Spacer; Echinocandins; Eurotiales; Fatal Outcome; Female; Granulomatous Disease, Chronic; Histocytochemistry; Humans; Interferon-gamma; Lipopeptides; Male; Microscopy; Molecular Sequence Data; Mycoses; Naphthalenes; Sequence Analysis, DNA; Terbinafine; Triazoles | 2011 |
Disseminated fusariosis occurring in two patients despite posaconazole prophylaxis.
Topics: Adult; Chemoprevention; Female; Fusarium; Humans; Immunocompromised Host; Male; Middle Aged; Mycoses; Triazoles | 2011 |
Lack of evidence for exposure-response relationship in the use of posaconazole as prophylaxis against invasive fungal infections.
Topics: Antifungal Agents; Clinical Trials as Topic; Dose-Response Relationship, Drug; Humans; Mycoses; Treatment Outcome; Triazoles | 2011 |
Successful treatment of Old World cutaneous leishmaniasis caused by Leishmania infantum with posaconazole.
Topics: Adult; Female; Humans; Leishmania infantum; Leishmaniasis, Cutaneous; Molecular Sequence Data; Polymerase Chain Reaction; Triazoles; Trypanocidal Agents | 2011 |
Multilaboratory testing of two-drug combinations of antifungals against Candida albicans, Candida glabrata, and Candida parapsilosis.
Topics: Amphotericin B; Anidulafungin; Antifungal Agents; Candida; Candida glabrata; Caspofungin; Drug Combinations; Echinocandins; Enzyme-Linked Immunosorbent Assay; Inhibitory Concentration 50; Lipopeptides; Micafungin; Microbial Sensitivity Tests; Pyrimidines; Triazoles; Voriconazole | 2011 |
Validation of 24-hour posaconazole and voriconazole MIC readings versus the CLSI 48-hour broth microdilution reference method: application of epidemiological cutoff values to results from a global Candida antifungal surveillance program.
Topics: Antifungal Agents; Candida; Humans; Microbial Sensitivity Tests; Pyrimidines; Time Factors; Triazoles; Voriconazole | 2011 |
Disseminated nocardiosis masking an atypical zygomycosis presentation in a kidney transplant recipient.
Topics: Amphotericin B; Antifungal Agents; Brain Abscess; Coinfection; Female; Humans; Kidney Transplantation; Middle Aged; Nocardia; Nocardia Infections; Opportunistic Infections; Pneumonia, Bacterial; Radiography; Triazoles; Zygomycosis | 2011 |
Risk factors for invasive aspergillosis in acute myeloid leukemia patients prophylactically treated with posaconazole.
Topics: Adult; Aged; Antifungal Agents; Aspergillosis; Case-Control Studies; Chemoprevention; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Risk Factors; Triazoles | 2011 |
Aspergillus fumigatus strains with mutations in the cyp51A gene do not always show phenotypic resistance to itraconazole, voriconazole, or posaconazole.
Topics: Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Cytochrome P-450 Enzyme System; Drug Resistance, Fungal; Fungal Proteins; Humans; Itraconazole; Mutation; Pyrimidines; Triazoles; Voriconazole | 2011 |
Endophthalmitis as primary clinical manifestation of fatal fusariosis in an allogeneic stem cell recipient.
Topics: Aged; Amphotericin B; Antifungal Agents; Endophthalmitis; Eye Infections, Fungal; Fatal Outcome; Fusariosis; Fusarium; Hematopoietic Stem Cell Transplantation; Humans; Immunocompromised Host; Male; Transplantation, Homologous; Triazoles | 2011 |
Activities of triazole-echinocandin combinations against Candida species in biofilms and as planktonic cells.
Topics: Anidulafungin; Antifungal Agents; Biofilms; Candida; Candida albicans; Caspofungin; Echinocandins; Lipopeptides; Microbial Sensitivity Tests; Plankton; Pyrimidines; Triazoles; Voriconazole | 2011 |
Attributable hospital cost and antifungal treatment of invasive fungal diseases in high-risk hematology patients: an economic modeling approach.
Topics: Adult; Aged; Aged, 80 and over; Amphotericin B; Antifungal Agents; Caspofungin; Echinocandins; Female; Hematology; Hospital Costs; Humans; Length of Stay; Lipopeptides; Male; Middle Aged; Models, Economic; Mycoses; Pyrimidines; Retrospective Studies; Triazoles; Voriconazole | 2011 |
Pharmacokinetics and pharmacodynamics of posaconazole for invasive pulmonary aspergillosis: clinical implications for antifungal therapy.
Topics: Animals; Antifungal Agents; Disease Models, Animal; Invasive Pulmonary Aspergillosis; Male; Mice; Models, Theoretical; Triazoles | 2011 |
Multicenter comparison of the Vitek 2 antifungal susceptibility test with the CLSI broth microdilution reference method for testing caspofungin, micafungin, and posaconazole against Candida spp.
Topics: Antifungal Agents; Automation; Candida; Caspofungin; Echinocandins; Humans; Lipopeptides; Micafungin; Microbial Sensitivity Tests; Triazoles; United States | 2011 |
Posaconazole in human serum: a greater pharmacodynamic effect than predicted by the non-protein-bound serum concentration.
Topics: Antifungal Agents; Candida; Culture Media, Serum-Free; Humans; Microbial Sensitivity Tests; Protein Binding; Serum; Triazoles | 2011 |
Failure of posaconazole therapy in a renal transplant patient with invasive aspergillosis due to Aspergillus fumigatus with attenuated susceptibility to posaconazole.
Topics: Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Female; Humans; Kidney Transplantation; Middle Aged; Triazoles | 2011 |
Transcriptional profiling of azole-resistant Candida parapsilosis strains.
Topics: Antifungal Agents; Azoles; Candida; Drug Resistance, Fungal; Fluconazole; Fungal Proteins; Gene Expression Profiling; Microbial Sensitivity Tests; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; Triazoles; Voriconazole | 2011 |
A prospective survey of Aspergillus spp. in respiratory tract samples: prevalence, clinical impact and antifungal susceptibility.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amphotericin B; Antifungal Agents; Aspergillosis; Aspergillus; Child; Child, Preschool; Denmark; Drug Resistance, Fungal; Female; Hospitals; Humans; Itraconazole; Male; Microbial Sensitivity Tests; Middle Aged; Prevalence; Prospective Studies; Pyrimidines; Respiratory System; Respiratory Tract Infections; Treatment Outcome; Triazoles; Voriconazole | 2011 |
Antifungal therapy in an athymic murine model of chromoblastomycosis by Fonsecaea pedrosoi.
Topics: Animals; Antifungal Agents; Ascomycota; Chromoblastomycosis; Itraconazole; Male; Mice; Mice, Nude; Mitosporic Fungi; Naphthalenes; Pyrimidines; Terbinafine; Triazoles; Voriconazole | 2011 |
Therapeutic drug monitoring of posaconazole in hematology adults under posaconazole prophylaxis: influence of food intake.
Topics: Adolescent; Adult; Aged; Antifungal Agents; Antineoplastic Agents; Chemoprevention; Drug Monitoring; Eating; Female; Hematologic Neoplasms; Humans; Male; Middle Aged; Mycoses; Triazoles; Young Adult | 2012 |
Disseminated sporotrichosis in a patient with hairy cell leukemia treated with amphotericin B and posaconazole.
Topics: Adult; Amphotericin B; Antifungal Agents; Humans; Leg; Leukemia, Hairy Cell; Male; Skin; Sporothrix; Sporotrichosis; Triazoles | 2012 |
Microdilution in vitro antifungal susceptibility of Exophiala dermatitidis, a systemic opportunist.
Topics: Antifungal Agents; Exophiala; Genotype; Humans; Microbial Sensitivity Tests; Phaeohyphomycosis; Pyrimidines; Triazoles; Voriconazole | 2011 |
Optimising absorption of posaconazole.
Topics: Absorption; Administration, Oral; Adult; Aged; Antifungal Agents; Female; Humans; Male; Middle Aged; Mycoses; Serum; Triazoles | 2011 |
Subcutaneous phaeohyphomycosis caused by Exophiala jeanselmei treated with wide surgical excision and posaconazole: case report.
Topics: Adult; Antifungal Agents; Exophiala; Humans; Male; Phaeohyphomycosis; Subcutaneous Tissue; Triazoles | 2013 |
Candida kefyr fungal enteritis following autologous BMT.
Topics: Bone Marrow Transplantation; Candida; Candidiasis; Endoscopy; Enteritis; Hematologic Neoplasms; Humans; Male; Middle Aged; Tomography, X-Ray Computed; Triazoles; Waldenstrom Macroglobulinemia | 2012 |
Fatal disseminated infection due to Scedosporium prolificans in a patient with acute myeloid leukemia and posaconazole prophylaxis.
Topics: Acute Disease; Aged; Antifungal Agents; Fatal Outcome; Humans; Leukemia, Myeloid; Male; Mycoses; Scedosporium; Triazoles | 2011 |
Cavitary lung lesions in a renal transplant recipient.
Topics: Amphotericin B; Antifungal Agents; Humans; Kidney Transplantation; Lung Diseases, Fungal; Male; Middle Aged; Mucormycosis; Radiography, Thoracic; Rhizopus; Triazoles | 2011 |
Cerebral mucormycosis in a diabetic man.
Topics: Amphotericin B; Antifungal Agents; Biopsy; Brain Diseases; Combined Modality Therapy; Diabetes Mellitus, Type 2; Diagnosis, Differential; Drug Therapy, Combination; Endoscopy; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Mucormycosis; Tomography, X-Ray Computed; Triazoles | 2011 |
Peripheral neuropathy in patients on long-term triazole antifungal therapy.
Topics: Adult; Aged; Antifungal Agents; Aspergillosis; Chronic Disease; Cohort Studies; Female; Humans; Itraconazole; Long-Term Care; Male; Middle Aged; Peripheral Nervous System Diseases; Pyrimidines; Retrospective Studies; Triazoles; Voriconazole; Young Adult | 2011 |
In vitro activity of a novel broad-spectrum antifungal, E1210, tested against Candida spp. as determined by CLSI broth microdilution method.
Topics: Antifungal Agents; Candida; Caspofungin; Culture Media; Dose-Response Relationship, Drug; Drug Resistance, Fungal; Echinocandins; Fluconazole; Lipopeptides; Microbial Sensitivity Tests; Pyrimidines; Triazoles; Voriconazole | 2011 |
Delayed recalcitrant fungal endophthalmitis secondary to Curvularia.
Topics: Abscess; Aged; Amphotericin B; Ascomycota; Cataract Extraction; Combined Modality Therapy; Drug Therapy, Combination; Endophthalmitis; Eye Enucleation; Eye Infections, Fungal; Female; Humans; Mycoses; Pyrimidines; Recurrence; Triazoles; Vitrectomy; Vitreous Body; Voriconazole | 2011 |
Antimalarial activity of potential inhibitors of Plasmodium falciparum lactate dehydrogenase enzyme selected by docking studies.
Topics: Animals; Antimalarials; Atorvastatin; Catalytic Domain; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Itraconazole; L-Lactate Dehydrogenase; Malaria; Mice; Plasmodium falciparum; Pyrroles; Triazoles | 2011 |
Selection of resistant fungi in liver transplant recipients during use of newer antifungal agents -- a report of two cases.
Topics: Adult; Antifungal Agents; Caspofungin; Drug Resistance, Fungal; Echinocandins; Fatal Outcome; Female; Fluconazole; Humans; Lipopeptides; Liver Transplantation; Male; Middle Aged; Mycoses; Pyrimidines; Triazoles; Trichosporonosis; Voriconazole; Young Adult | 2011 |
Long-term treatment of invasive sinus, tracheobroncheal, pulmonary and intracerebral aspergillosis in acute lymphoblastic leukaemia.
Topics: Amphotericin B; Antifungal Agents; Aspergillus fumigatus; Brain; Caspofungin; Cerebrum; Echinocandins; Humans; Larynx; Lipopeptides; Lung; Magnetic Resonance Imaging; Male; Middle Aged; Neuroaspergillosis; Paranasal Sinuses; Peripheral Nervous System Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pulmonary Aspergillosis; Pyrimidines; Sweden; Tomography, X-Ray Computed; Triazoles; Voriconazole | 2012 |
Madurella mycetomatis mycetoma treated successfully with oral posaconazole.
Topics: Administration, Oral; Antifungal Agents; Humans; Madurella; Male; Mycetoma; Triazoles; Young Adult | 2011 |
In vitro activities of new triazole antifungal agents, posaconazole and voriconazole, against oral Candida isolates from patients suffering from denture stomatitis.
Topics: Antifungal Agents; Candida; Humans; Microbial Sensitivity Tests; Pyrimidines; Stomatitis, Denture; Triazoles; Voriconazole | 2012 |
Rapid and sensitive determination of posaconazole in patient plasma by capillary electrophoresis with field-amplified sample stacking.
Topics: Electrophoresis, Capillary; Humans; Hydrophobic and Hydrophilic Interactions; Limit of Detection; Linear Models; Reproducibility of Results; Solid Phase Extraction; Triazoles | 2012 |
Rhino-orbital-cerebral mucormycosis (ROCM): a comprehensive case review.
Topics: Adult; Amphotericin B; Antifungal Agents; Brain Diseases; Debridement; Diabetes Insipidus, Nephrogenic; Diabetes Mellitus, Type 1; Disease Progression; Eye Infections, Fungal; Humans; Immunocompromised Host; Magnetic Resonance Imaging; Male; Mucormycosis; Nose Diseases; Orbital Diseases; Tomography, X-Ray Computed; Triazoles | 2011 |
74-year-old man from the pacific northwest with fever and a lung mass.
Topics: Aged; Amphotericin B; Antifungal Agents; British Columbia; Bromhexine; Cryptococcosis; Cryptococcus gattii; Flucytosine; Humans; Lung Diseases, Fungal; Male; Microbial Sensitivity Tests; Radiography; Triazoles | 2011 |
Wild-type MIC distributions and epidemiologic cutoff values for fluconazole, posaconazole, and voriconazole when testing Cryptococcus neoformans as determined by the CLSI broth microdilution method.
Topics: Antifungal Agents; Cryptococcus neoformans; Drug Resistance, Fungal; Fluconazole; Humans; Microbial Sensitivity Tests; Pyrimidines; Reference Values; Triazoles; Voriconazole | 2011 |
EUCAST technical note on posaconazole.
Topics: Antifungal Agents; Candida; Humans; Microbial Sensitivity Tests; Triazoles | 2011 |
Concentration of antifungal agents within host cell membranes: a new paradigm governing the efficacy of prophylaxis.
Topics: Antifungal Agents; Aspergillus fumigatus; Cell Line; Cell Membrane; Chemoprevention; Epithelial Cells; Humans; Itraconazole; Lung; Macrophages; Mycoses; Triazoles | 2011 |
In vitro activity of Amphotericin B against zygomycetes isolated from deep mycoses: a comparative study between incubation in aerobic and hyperbaric atmosphere.
Topics: Aerobiosis; Amphotericin B; Antifungal Agents; Atmospheric Pressure; Fungi; Humans; Microbial Sensitivity Tests; Triazoles; Zygomycosis | 2012 |
In vitro antifungal susceptibility of Malassezia pachydermatis from dogs with and without skin lesions.
Topics: Animals; Antifungal Agents; Dermatomycoses; Dog Diseases; Dogs; Fluconazole; Itraconazole; Ketoconazole; Malassezia; Miconazole; Naphthalenes; Pyrimidines; Terbinafine; Triazoles; Voriconazole | 2012 |
Posaconazole for chronic refractory coccidioidal meningitis.
Topics: Adolescent; Adult; Antifungal Agents; Chronic Disease; Coccidioides; Coccidioidomycosis; Humans; Male; Meningitis, Fungal; Treatment Outcome; Triazoles; Young Adult | 2011 |
Breakthrough fungemia due to Candida glabrata during posaconazole prophylaxis in hematology patients treated with anidulafungin - report of 5 cases.
Topics: Adult; Anidulafungin; Antifungal Agents; Candida glabrata; Candidiasis; Drug Resistance, Fungal; Echinocandins; Female; Fungemia; Humans; Immunocompromised Host; Leukemia; Male; Middle Aged; Slovakia; Treatment Outcome; Triazoles | 2011 |
Fluoride excess in coccidioidomycosis patients receiving long-term antifungal therapy: an assessment of currently available triazoles.
Topics: Adolescent; Adult; Antifungal Agents; Coccidioides; Coccidioidomycosis; Cohort Studies; Exostoses; Female; Fluconazole; Fluorides; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Periostitis; Pyrimidines; Triazoles; United States; Voriconazole | 2012 |
In vitro acquisition of secondary azole resistance in Aspergillus fumigatus isolates after prolonged exposure to itraconazole: presence of heteroresistant populations.
Topics: Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Codon; Culture Media; Cytochrome P-450 Enzyme System; DNA Mutational Analysis; Drug Resistance, Fungal; Fungal Proteins; Humans; Itraconazole; Microbial Sensitivity Tests; Mutation; Mycological Typing Techniques; Pyrimidines; Time Factors; Triazoles; Voriconazole | 2012 |
A common fungus, an unusual (and deadly) infection.
Topics: Amphotericin B; Antifungal Agents; Biopsy; Debridement; Fatal Outcome; Female; Hemochromatosis; Hepatic Encephalopathy; Humans; Intubation, Gastrointestinal; Liver; Liver Failure, Acute; Middle Aged; Mucormycosis; Necrosis; Nose; Nose Diseases; Opportunistic Infections; Triazoles | 2011 |
Antifungal susceptibilities of Aspergillus fumigatus clinical isolates obtained in Nagasaki, Japan.
Topics: Amino Acid Substitution; Amphotericin B; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Cytochrome P-450 Enzyme System; Drug Resistance, Fungal; Echinocandins; Female; Fungal Proteins; Humans; Itraconazole; Japan; Lipopeptides; Male; Micafungin; Microbial Sensitivity Tests; Mutation; Pyrimidines; Sequence Analysis, DNA; Triazoles; Voriconazole | 2012 |
A dried blood spots technique based LC-MS/MS method for the analysis of posaconazole in human whole blood samples.
Topics: Blood Specimen Collection; Chromatography, Liquid; Desiccation; Drug Stability; Hematocrit; Humans; Linear Models; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Triazoles | 2011 |
Treatment of refractory coccidioidomycosis with voriconazole or posaconazole.
Topics: Adult; Aged; Antifungal Agents; Coccidioidomycosis; Female; Humans; Male; Middle Aged; Pyrimidines; Retrospective Studies; Salvage Therapy; Southwestern United States; Treatment Outcome; Triazoles; Voriconazole | 2011 |
Antifungal treatment affects the laboratory diagnosis of invasive aspergillosis.
Topics: Amphotericin B; Animals; Antifungal Agents; Aspergillus fumigatus; Biomarkers; Caspofungin; Disease Models, Animal; DNA, Fungal; Early Diagnosis; Echinocandins; Galactose; Immunoenzyme Techniques; Invasive Pulmonary Aspergillosis; Lipopeptides; Mannans; Microbiological Techniques; Mycological Typing Techniques; Predictive Value of Tests; Rats; Real-Time Polymerase Chain Reaction; Time Factors; Triazoles | 2012 |
Comparative clinical effectiveness of prophylactic voriconazole/posaconazole to fluconazole/itraconazole in patients with acute myeloid leukemia/myelodysplastic syndrome undergoing cytotoxic chemotherapy over a 12-year period.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibiotic Prophylaxis; Antifungal Agents; Female; Fluconazole; Humans; Itraconazole; Leukemia, Myeloid, Acute; Male; Medication Adherence; Middle Aged; Mycoses; Myelodysplastic Syndromes; Pyrimidines; Retrospective Studies; Treatment Outcome; Triazoles; Voriconazole; Young Adult | 2012 |
Activities of E1210 and comparator agents tested by CLSI and EUCAST broth microdilution methods against Fusarium and Scedosporium species identified using molecular methods.
Topics: Acylation; Aminopyridines; Amphotericin B; Anidulafungin; Antifungal Agents; Caspofungin; Echinocandins; Fusarium; Glycosylphosphatidylinositols; Humans; Inositol; Isoxazoles; Itraconazole; Lipopeptides; Microbial Sensitivity Tests; Pyrimidines; Scedosporium; Triazoles; Voriconazole | 2012 |
Structural determination of an unknown degradation product in posaconazole drug product using CASI technology in a Fourier transform ion cyclotron resonance mass spectrometer.
Topics: Cyclotrons; Fourier Analysis; Ions; Mass Spectrometry; Models, Molecular; Triazoles | 2011 |
Posaconazole prophylaxis during front-line chemotherapy of acute myeloid leukemia: a single-center, real-life experience.
Topics: Adult; Aged; Antibiotic Prophylaxis; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Female; Hospitalization; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Mycoses; Survival Analysis; Treatment Outcome; Triazoles; Young Adult | 2012 |
Success of posaconazole therapy in a heart transplanted patient with Alternaria infectoria cutaneous infection.
Topics: Alternaria; Alternariosis; Antifungal Agents; Female; Heart Transplantation; Humans; Middle Aged; Treatment Outcome; Triazoles | 2012 |
Identification of a Cryptococcus neoformans cytochrome P450 lanosterol 14α-demethylase (Erg11) residue critical for differential susceptibility between fluconazole/voriconazole and itraconazole/posaconazole.
Topics: 14-alpha Demethylase Inhibitors; Animals; Antifungal Agents; Cryptococcosis; Cryptococcus neoformans; Drug Resistance, Fungal; Female; Fluconazole; Fungal Proteins; Genotype; Humans; Itraconazole; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Mutation, Missense; Phenylalanine; Pyrimidines; Sterol 14-Demethylase; Survival Rate; Triazoles; Tyrosine; Voriconazole | 2012 |
HPLC/UV or bioassay: two valid methods for posaconazole quantification in human serum samples.
Topics: Antifungal Agents; Biological Assay; Chromatography, High Pressure Liquid; Humans; Male; Serum; Spectrophotometry, Ultraviolet; Triazoles | 2012 |
New species of Madurella, causative agents of black-grain mycetoma.
Topics: Antifungal Agents; DNA, Fungal; DNA, Ribosomal Spacer; Fungal Proteins; Humans; Leg; Madurella; Male; Microbial Sensitivity Tests; Middle Aged; Molecular Sequence Data; Mycetoma; Phylogeny; Pyrimidines; RNA Polymerase II; Sequence Analysis, DNA; Sudan; Triazoles; Tubulin; Voriconazole | 2012 |
Combination therapy for mucormycosis: why, what, and how?
Topics: Animals; Antifungal Agents; Benzoates; Clinical Trials as Topic; Deferasirox; Drug Therapy, Combination; Echinocandins; Humans; Lipids; Mice; Mucormycosis; Polyenes; Treatment Outcome; Triazoles | 2012 |
Posaconazole serum level on day 2 predicts steady state posaconazole serum level.
Topics: Adult; Aged; Aged, 80 and over; Antifungal Agents; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Mycoses; Triazoles; Young Adult | 2012 |
[53-year-old woman with life-threatening complications after use of ciprofloxacin and posaconazol].
Topics: Anti-Infective Agents; Cardiopulmonary Resuscitation; Ciprofloxacin; Electrocardiography; Female; Humans; Leukemia; Long QT Syndrome; Middle Aged; Risk Factors; Triazoles | 2012 |
Factors influencing the pharmacokinetics of prophylactic posaconazole oral suspension in patients with acute myeloid leukemia or myelodysplastic syndrome.
Topics: Adult; Aged; Antifungal Agents; Antineoplastic Agents; Cohort Studies; Humans; Leukemia, Myeloid, Acute; Middle Aged; Models, Biological; Mycoses; Myelodysplastic Syndromes; Suspensions; Triazoles; Young Adult | 2012 |
In vitro and in vivo activities of posaconazole and amphotericin B in a murine invasive infection by Mucor circinelloides: poor efficacy of posaconazole.
Topics: Amphotericin B; Animals; Antifungal Agents; Brain; Disease Models, Animal; Drug Resistance, Fungal; Kidney; Male; Mice; Microbial Sensitivity Tests; Mucor; Mucormycosis; Neutropenia; Species Specificity; Survival Rate; Treatment Failure; Triazoles | 2012 |
Species-specific antifungal susceptibility patterns of Scedosporium and Pseudallescheria species.
Topics: Amplified Fragment Length Polymorphism Analysis; Antifungal Agents; Bacterial Typing Techniques; Dose-Response Relationship, Drug; Drug Resistance, Fungal; Echinocandins; Humans; Lipopeptides; Micafungin; Microbial Sensitivity Tests; Pseudallescheria; Pyrimidines; Scedosporium; Species Specificity; Triazoles; Voriconazole | 2012 |
Epidemiological cutoff values for azoles and Aspergillus fumigatus based on a novel mathematical approach incorporating cyp51A sequence analysis.
Topics: Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Cytochrome P-450 Enzyme System; Drug Resistance, Fungal; Fungal Proteins; Humans; Itraconazole; Longitudinal Studies; Mathematical Computing; Microbial Sensitivity Tests; Models, Statistical; Mutation; Netherlands; Promoter Regions, Genetic; Pyrimidines; Sequence Analysis, DNA; Tandem Repeat Sequences; Triazoles; Voriconazole | 2012 |
Efficacy of posaconazole in murine experimental sporotrichosis.
Topics: Administration, Oral; Amphotericin B; Animals; Antifungal Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Histocytochemistry; Liver; Male; Mice; Microbial Sensitivity Tests; Species Specificity; Sporothrix; Sporotrichosis; Survival Rate; Treatment Outcome; Triazoles | 2012 |
T. asahii pulmonary infection as a complication of TNF-inhibitor and steroids: posaconazole pharmacotherapy and risk analysis.
Topics: Adalimumab; Adolescent; Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antifungal Agents; Arthritis, Rheumatoid; Female; Glucocorticoids; Graft vs Host Disease; Humans; Immunosuppressive Agents; Infliximab; Lung Diseases, Fungal; Male; Middle Aged; Risk Assessment; Risk Factors; Root Cause Analysis; Triazoles; Trichosporonosis; Tumor Necrosis Factor Inhibitors; Young Adult | 2011 |
A murine model of Cryptococcus gattii meningoencephalitis.
Topics: Animals; Antifungal Agents; Antigens, Fungal; Brain; Colony Count, Microbial; Cryptococcosis; Cryptococcus gattii; Cryptococcus neoformans; Disease Models, Animal; Fluconazole; Histocytochemistry; Meningoencephalitis; Mice; Mice, Inbred ICR; Survival Analysis; Triazoles | 2012 |
Voriconazole and posaconazole improve asthma severity in allergic bronchopulmonary aspergillosis and severe asthma with fungal sensitization.
Topics: Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Antifungal Agents; Aspergillosis, Allergic Bronchopulmonary; Asthma; Comorbidity; Drug Utilization; Female; Health Services; Humans; Lung Diseases, Fungal; Male; Middle Aged; Pyrimidines; Quality of Life; Radiography, Thoracic; Retrospective Studies; Severity of Illness Index; Socioeconomic Factors; Spirometry; Triazoles; Voriconazole | 2012 |
Successful treatment of cutaneous zygomycosis with extensive surgical debridement and oral posaconazole in an immunocompetent patient.
Topics: Administration, Oral; Antifungal Agents; Combined Modality Therapy; Debridement; Dermatomycoses; Female; Follow-Up Studies; Humans; Immunocompetence; Leg Injuries; Middle Aged; Risk Assessment; Severity of Illness Index; Treatment Outcome; Triazoles; Zygomycosis | 2012 |
Efficacy of posaconazole in a murine model of disseminated infection caused by Apophysomyces variabilis.
Topics: Amphotericin B; Animals; Antifungal Agents; Disease Models, Animal; Humans; Injections, Intravenous; Male; Mice; Microbial Sensitivity Tests; Mucorales; Mucormycosis; Treatment Outcome; Triazoles | 2012 |
Experimental murine model of disseminated infection by Saksenaea vasiformis: successful treatment with posaconazole.
Topics: Amphotericin B; Animals; Antifungal Agents; Disease Models, Animal; Male; Mice; Microbial Sensitivity Tests; Mucorales; Mucormycosis; Treatment Outcome; Triazoles | 2012 |
Structural characterization of a novel degradant of the antifungal agent posaconazole.
Topics: Antifungal Agents; Benzodiazepines; Chromatography, Liquid; Magnetic Resonance Spectroscopy; Mass Spectrometry; Piperazine; Piperazines; Tandem Mass Spectrometry; Triazoles | 2012 |
Cost-effectiveness of posaconazole versus fluconazole or itraconazole in the prevention of invasive fungal infections among high-risk neutropenic patients in Spain.
Topics: Antifungal Agents; Chemoprevention; Cost-Benefit Analysis; Hematologic Neoplasms; Humans; Immunocompromised Host; Itraconazole; Mycoses; Neutropenia; Prospective Studies; Spain; Triazoles | 2012 |
Posaconazole plasma concentrations and invasive mould infections in patients with haematological malignancies.
Topics: Adult; Antifungal Agents; Aspergillosis; Chemoprevention; Drug Monitoring; Female; Hematologic Neoplasms; Humans; Male; Middle Aged; Mycoses; Risk Factors; Triazoles; Young Adult | 2012 |
[Cerebral aspergillosis in an human immunodeficiency virus infected patient].
Topics: Adult; AIDS Serodiagnosis; AIDS-Related Opportunistic Infections; Anti-HIV Agents; Antifungal Agents; Brain Edema; Cytomegalovirus Infections; Female; HIV Infections; Humans; Magnetic Resonance Imaging; Morocco; Neuroaspergillosis; Serratia Infections; Toxoplasmosis, Cerebral; Triazoles | 2012 |
[Ambulatory therapy of aspergillosis in hematological and oncological patients].
Topics: Ambulatory Care; Antifungal Agents; Caspofungin; Echinocandins; Hematologic Diseases; Humans; Invasive Pulmonary Aspergillosis; Itraconazole; Lipopeptides; Neutropenia; Pyrimidines; Salvage Therapy; Triazoles; Voriconazole | 2012 |
[In vitro synergisms among hydrazones, ajoeno and posaconazole against Cryptococcus spp].
Topics: Antifungal Agents; Candida; Cryptococcus gattii; Cryptococcus neoformans; Disulfides; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Resistance, Fungal; Drug Synergism; Hydrazones; In Vitro Techniques; Microbial Sensitivity Tests; Sulfoxides; Triazoles | 2011 |
In vitro antifungal susceptibility of filamentous fungi causing rare infections: synergy testing of amphotericin B, posaconazole and anidulafungin in pairs.
Topics: Amphotericin B; Anidulafungin; Antifungal Agents; Drug Synergism; Echinocandins; Fungi; Humans; Microbial Sensitivity Tests; Mycoses; Triazoles | 2012 |
EUCAST technical note on Aspergillus and amphotericin B, itraconazole, and posaconazole.
Topics: Amphotericin B; Antifungal Agents; Aspergillus; Europe; Humans; Itraconazole; Microbial Sensitivity Tests; Triazoles | 2012 |
Posaconazole treatment in hematology patients: a pilot study of therapeutic drug monitoring.
Topics: Adult; Antifungal Agents; Drug Monitoring; Female; Follow-Up Studies; Hematologic Diseases; Humans; Male; Middle Aged; Mycoses; Pilot Projects; Retrospective Studies; Treatment Outcome; Triazoles | 2012 |
Safety of posaconazole and sirolimus coadministration in allogeneic hematopoietic stem cell transplants.
Topics: Adult; Antifungal Agents; Drug Administration Schedule; Drug Dosage Calculations; Drug Synergism; Drug Therapy, Combination; Female; Graft vs Host Disease; Hematologic Neoplasms; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Male; Middle Aged; Mycoses; Sirolimus; Transplantation, Homologous; Triazoles | 2012 |
Successful use of posaconazole for treatment of blastomycosis.
Topics: Adult; Antifungal Agents; Blastomycosis; Female; Humans; Itraconazole; Male; Middle Aged; Triazoles | 2012 |
High prevalence of triazole resistance in Aspergillus fumigatus, especially mediated by TR/L98H, in a French cohort of patients with cystic fibrosis.
Topics: Adolescent; Adult; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Child; Child, Preschool; Cystic Fibrosis; Drug Resistance, Fungal; France; Humans; In Vitro Techniques; Itraconazole; Male; Microbial Sensitivity Tests; Middle Aged; Prevalence; Pyrimidines; Retrospective Studies; Sequence Analysis, DNA; Triazoles; Tubulin; Voriconazole; Young Adult | 2012 |
Plasma concentrations of posaconazole administered via nasogastric tube in patients in a surgical intensive care unit.
Topics: Adult; Aged; Antifungal Agents; Biological Availability; Chromatography, High Pressure Liquid; Critical Care; Female; Humans; Intubation, Gastrointestinal; Male; Middle Aged; Triazoles | 2012 |
Renal mucormycosis complicating extracorporeal membrane oxygenation.
Topics: Acute Kidney Injury; Aged; Amphotericin B; Antifungal Agents; Cross Infection; Extracorporeal Membrane Oxygenation; Female; France; Heart Failure; Humans; Immunocompromised Host; Kidney; Mucormycosis; Rheumatic Fever; Rhizopus; Treatment Outcome; Triazoles; Tuberculosis, Pulmonary | 2013 |
Effects of amiodarone and posaconazole on the growth and ultrastructure of Trypanosoma cruzi.
Topics: Amiodarone; Animals; Antimalarials; Autophagy; Cell Survival; Drug Interactions; Inhibitory Concentration 50; Mice; Microscopy, Electron; Organelles; Triazoles; Trypanosoma cruzi | 2012 |
Invasive fungal breakthrough infections, fungal colonization and emergence of resistant strains in high-risk patients receiving antifungal prophylaxis with posaconazole: real-life data from a single-centre institutional retrospective observational study.
Topics: Antifungal Agents; Chemoprevention; Drug Resistance, Fungal; Fungi; Humans; Immunocompromised Host; Incidence; Mycoses; Retrospective Studies; Triazoles | 2012 |
Characterization of an unusual ring-contraction degradant of the antifungal agent posaconazole.
Topics: Antifungal Agents; Magnetic Resonance Spectroscopy; Molecular Structure; Reference Standards; Triazoles | 2012 |
Correlation between triazole treatment history and susceptibility in clinically isolated Aspergillus fumigatus.
Topics: Aged; Aged, 80 and over; Antifungal Agents; Aspergillus fumigatus; Cytochrome P-450 Enzyme System; Drug Resistance, Fungal; Female; Fungal Proteins; Humans; Itraconazole; Male; Microbial Sensitivity Tests; Middle Aged; Mutation; Pulmonary Aspergillosis; Time Factors; Triazoles | 2012 |
Pharmacological characterization, structural studies, and in vivo activities of anti-Chagas disease lead compounds derived from tipifarnib.
Topics: 14-alpha Demethylase Inhibitors; Administration, Oral; Alkyl and Aryl Transferases; Animals; Chagas Disease; Crystallography, X-Ray; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Administration Schedule; Female; Humans; Mice; Models, Molecular; Nitroimidazoles; Quinolones; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2012 |
The management of febrile neutropenia in the posaconazole era: a new challenge?
Topics: Antifungal Agents; Antineoplastic Agents; Fever; Fungi; Galactose; Hematopoietic Stem Cell Transplantation; Humans; Leukemia, Myeloid, Acute; Mannans; Mycoses; Neutropenia; Polymerase Chain Reaction; Randomized Controlled Trials as Topic; Retrospective Studies; Triazoles | 2012 |
Emergence of Aspergillus calidoustus infection in the era of posttransplantation azole prophylaxis.
Topics: Adult; Aged; Antifungal Agents; Aspergillosis; Aspergillus; Female; Humans; Lung Transplantation; Male; Microbial Sensitivity Tests; Middle Aged; Pyrimidines; Retrospective Studies; Risk Factors; Triazoles; Voriconazole | 2012 |
Analysis of sequence, structure of GAPDH of Leishmania donovani and its interactions.
Topics: Amino Acid Sequence; Binding Sites; DNA Primers; Glyceraldehyde-3-Phosphate Dehydrogenases; Leishmania donovani; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Sequence Data; NAD; Phylogeny; Protein Binding; Protein Processing, Post-Translational; Protein Subunits; Reproducibility of Results; RNA, Protozoan; Sequence Analysis, Protein; Thermodynamics; Triazoles | 2013 |
Posaconazole as successful treatment for fungemia due to Cryptococcus albidus in a liver transplant recipient.
Topics: Antifungal Agents; Cryptococcosis; Fungemia; Humans; Liver Transplantation; Male; Middle Aged; Opportunistic Infections; Triazoles | 2013 |
Therapeutic drug monitoring of posaconazole in allogeneic hematopoietic stem cell transplantation patients who develop gastrointestinal graft-versus-host disease.
Topics: Adult; Aged; Aged, 80 and over; Antifungal Agents; Female; Gastrointestinal Diseases; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Invasive Pulmonary Aspergillosis; Male; Middle Aged; Retrospective Studies; Triazoles | 2012 |
Zygomycosis over-infection during voriconazole therapy for aspergillosis in a heart transplant patient, successfully treated with liposomal amphotericin and posaconazole.
Topics: Amphotericin B; Antifungal Agents; Debridement; Drug Therapy, Combination; Heart Transplantation; Humans; Immunocompromised Host; Invasive Pulmonary Aspergillosis; Male; Middle Aged; Pyrimidines; Sinusitis; Treatment Outcome; Triazoles; Voriconazole; Zygomycosis | 2012 |
Are epidemiologic cut-off values predictors of the in vivo efficacy of azoles in experimental aspergillosis?
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus flavus; Aspergillus niger; Disease Models, Animal; Male; Mice; Microbial Sensitivity Tests; Pyrimidines; Treatment Outcome; Triazoles; Voriconazole | 2012 |
Reversible skeletal disease and high fluoride serum levels in hematologic patients receiving voriconazole.
Topics: Adult; Antifungal Agents; Bone Diseases; Female; Fluorides; Hematologic Neoplasms; Humans; Itraconazole; Middle Aged; Muscle, Skeletal; Periostitis; Pyrimidines; Retrospective Studies; Stem Cell Transplantation; Transplantation, Homologous; Triazoles; Voriconazole | 2012 |
Poor absorption of high-dose posaconazole in pediatric bone marrow transplant patients.
Topics: Absorption; Antifungal Agents; Bone Marrow Transplantation; Child; Humans; Infant; Male; Mycoses; Triazoles | 2012 |
Meningitis due to Cryptococcus neoformans: treatment with posaconazole.
Topics: Administration, Oral; Adult; AIDS-Related Opportunistic Infections; Amphotericin B; Antifungal Agents; Cryptococcus neoformans; Humans; Male; Meningitis, Cryptococcal; Mexico; Microbial Sensitivity Tests; Treatment Outcome; Triazoles | 2012 |
Multicenter study of posaconazole therapeutic drug monitoring: exposure-response relationship and factors affecting concentration.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antifungal Agents; Australia; Dose-Response Relationship, Drug; Drug Monitoring; Drug Therapy, Combination; Female; Fungi; Humans; Logistic Models; Male; Metoclopramide; Middle Aged; Mycoses; Phenytoin; Ranitidine; Retrospective Studies; Rifampin; Triazoles | 2012 |
In vitro-in vivo correlation of voriconazole resistance due to G448S mutation (cyp51A gene) in Aspergillus fumigatus.
Topics: Animals; Antifungal Agents; Aspergillus fumigatus; Cytochrome P-450 Enzyme System; Disease Models, Animal; Drug Resistance, Fungal; Female; Fungal Proteins; Humans; Mice; Mice, Inbred ICR; Mutation, Missense; Pulmonary Aspergillosis; Pyrimidines; Treatment Outcome; Triazoles; Voriconazole | 2012 |
Cutaneous phaeohyphomycosis caused by Paraconiothyrium cyclothyrioides.
Topics: Antifungal Agents; Ascomycota; DNA, Fungal; Humans; Immunocompromised Host; Kidney Transplantation; Lower Extremity; Male; Middle Aged; Molecular Sequence Data; Phaeohyphomycosis; Sequence Analysis, DNA; Transplantation; Treatment Outcome; Triazoles | 2012 |
In vitro activities of nine antifungal drugs against 81 Phialophora and Cyphellophora isolates.
Topics: Amphotericin B; Antifungal Agents; Caspofungin; Echinocandins; Fluconazole; Itraconazole; Lipopeptides; Micafungin; Microbial Sensitivity Tests; Mitosporic Fungi; Naphthalenes; Nitriles; Phialophora; Pyridines; Pyrimidines; Terbinafine; Triazoles; Voriconazole | 2012 |
Cryptococcus neoformans-Cryptococcus gattii species complex: an international study of wild-type susceptibility endpoint distributions and epidemiological cutoff values for fluconazole, itraconazole, posaconazole, and voriconazole.
Topics: Antifungal Agents; Australia; Cryptococcosis; Cryptococcus gattii; Drug Resistance, Fungal; Europe; Fluconazole; Humans; India; Itraconazole; Microbial Sensitivity Tests; North America; Pyrimidines; South Africa; South America; Triazoles; Voriconazole | 2012 |
Invasive mucormycosis in an immunocompetent patient with allergic fungal rhinosinusitis.
Topics: Antifungal Agents; Biopsy, Needle; Endoscopy; Follow-Up Studies; Fungemia; Humans; Immunocompetence; Immunohistochemistry; Male; Middle Aged; Mucorales; Mucormycosis; Rhinitis, Allergic, Perennial; Risk Assessment; Sinusitis; Treatment Outcome; Triazoles | 2013 |
Case report of hepatic mucormycosis after liver transplantation: successful treatment with liposomal amphotericin B followed by posaconazole sequential therapy.
Topics: Amphotericin B; Antifungal Agents; Drug Administration Schedule; Female; Humans; Immunosuppressive Agents; Liver Diseases; Liver Transplantation; Mucormycosis; Time Factors; Treatment Outcome; Triazoles; Young Adult | 2012 |
Effect of posaconazole on cyclosporine blood levels and dose adjustment in allogeneic blood and marrow transplant recipients.
Topics: Adolescent; Adult; Aged; Antifungal Agents; Blood Transfusion; Bone Marrow Transplantation; Cyclosporine; Drug Interactions; Drug Monitoring; Female; Humans; Immunosuppressive Agents; Leukemia, Myeloid; Lymphoproliferative Disorders; Male; Middle Aged; Mycoses; Myelodysplastic Syndromes; Triazoles; Young Adult | 2012 |
The surgical management of rhinocerebral mucormycosis.
Topics: Adolescent; Adult; Aged; Amphotericin B; Antifungal Agents; Brain Diseases; Cause of Death; Combined Modality Therapy; Diagnosis, Differential; Fatal Outcome; Female; Hematologic Neoplasms; Humans; Immunocompromised Host; Male; Maxillary Sinusitis; Middle Aged; Mucormycosis; Nose Diseases; Paranasal Sinus Diseases; Pyrimidines; Triazoles; Voriconazole; Young Adult | 2013 |
Evaluation of benznidazole treatment combined with nifurtimox, posaconazole or AmBisome® in mice infected with Trypanosoma cruzi strains.
Topics: Amphotericin B; Animals; Chagas Disease; Disease Models, Animal; DNA, Protozoan; Drug Therapy, Combination; Female; Mice; Mice, Inbred BALB C; Nifurtimox; Nitroimidazoles; Parasite Load; Parasitemia; Real-Time Polymerase Chain Reaction; Treatment Outcome; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2012 |
Evaluation of an alternative posaconazole prophylaxis regimen in haematological malignancy patients receiving concomitant stress ulcer prophylaxis.
Topics: Adult; Aged; Antifungal Agents; Chemoprevention; Drug Interactions; Female; Hematologic Neoplasms; Humans; Male; Middle Aged; Mycoses; Plasma; Proton Pump Inhibitors; Stress, Physiological; Triazoles; Ulcer | 2012 |
Analysis of posaconazole as oral antifungal prophylaxis in pediatric patients under 12 years of age following allogeneic stem cell transplantation.
Topics: Antifungal Agents; Chemoprevention; Child; Child, Preschool; Female; Humans; Immunocompromised Host; Infant; Male; Mycoses; Retrospective Studies; Stem Cell Transplantation; Treatment Outcome; Triazoles | 2012 |
Pulmonary mucormycosis: what is the best strategy for therapy?
Topics: Acute Kidney Injury; Adult; Amphotericin B; Antifungal Agents; Debridement; Echinocandins; Humans; Lipopeptides; Lung Diseases, Fungal; Male; Micafungin; Mucormycosis; Pneumonectomy; Triazoles | 2013 |
[Disseminated infection due to Geotrichum capitatum].
Topics: Aged; Anti-Bacterial Agents; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Caspofungin; Drug Resistance, Multiple, Fungal; Drug Therapy, Combination; Echinocandins; Fatal Outcome; Fungemia; Geotrichosis; Geotrichum; Granuloma; Hepatitis; Humans; Immunocompromised Host; Leukemia, Myeloid, Acute; Lipopeptides; Male; Neutropenia; Opportunistic Infections; Sepsis; Triazoles | 2012 |
A simple high-performance liquid chromatography method for simultaneous determination of three triazole antifungals in human plasma.
Topics: Antifungal Agents; Calibration; Chromatography, High Pressure Liquid; Humans; Itraconazole; Limit of Detection; Naproxen; Observer Variation; Pyrimidines; Reference Standards; Reproducibility of Results; Triazoles; Voriconazole | 2013 |
Posaconazole pharmacodynamic target determination against wild-type and Cyp51 mutant isolates of Aspergillus fumigatus in an in vivo model of invasive pulmonary aspergillosis.
Topics: Administration, Oral; Animals; Antifungal Agents; Area Under Curve; Aspergillus fumigatus; Colony Count, Microbial; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fungal Proteins; Humans; Immunocompromised Host; Invasive Pulmonary Aspergillosis; Lung; Mice; Microbial Sensitivity Tests; Mutation; Sterol 14-Demethylase; Survival Analysis; Triazoles | 2013 |
Posaconazole after previous antifungal therapy with voriconazole for therapy of invasive aspergillus disease, a retrospective analysis.
Topics: Adolescent; Adult; Aged; Alanine Transaminase; Antifungal Agents; Aspartate Aminotransferases; Aspergillosis; Drug Evaluation; Female; gamma-Glutamyltransferase; Humans; Liver; Male; Middle Aged; Pyrimidines; Retrospective Studies; Time Factors; Treatment Outcome; Triazoles; Voriconazole; Young Adult | 2013 |
A non-fatal case of invasive zygomycete (Lichtheimia corymbifera) infection in an allogeneic haematopoietic cell transplant recipient.
Topics: Antifungal Agents; Hematopoietic Stem Cell Transplantation; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Magnetic Resonance Imaging; Male; Middle Aged; Mucorales; Mucormycosis; Peripheral Blood Stem Cell Transplantation; Triazoles; Vidarabine | 2013 |
Real-world experience with posaconazole prophylaxis in high-risk hematological patients in Singapore: a prospective audit.
Topics: Administration, Oral; Adult; Antifungal Agents; Hematologic Diseases; Hematopoietic Stem Cell Transplantation; Humans; Immunocompromised Host; Medical Audit; Middle Aged; Mycoses; Prospective Studies; Singapore; Treatment Outcome; Triazoles | 2013 |
Organocatalytic, enantioselective synthesis of VNI: a robust therapeutic development platform for Chagas, a neglected tropical disease.
Topics: Animals; Chagas Disease; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Imidazoles; Mice; Molecular Structure; Neglected Diseases; Oxadiazoles; Triazoles; Tropical Medicine; Trypanosoma cruzi | 2012 |
Tacrolimus enhances the potency of posaconazole against Rhizopus oryzae in vitro and in an experimental model of mucormycosis.
Topics: Animals; Antifungal Agents; Disease Models, Animal; Drosophila; Drug Synergism; Drug Therapy, Combination; Female; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Mucormycosis; Rhizopus; Tacrolimus; Treatment Outcome; Triazoles | 2013 |
A rash in a patient with neutropenia.
Topics: Aged; Antifungal Agents; Dermatomycoses; Fever; Fusariosis; Fusarium; Humans; Leukemia, Myeloid, Acute; Male; Neutropenia; Triazoles | 2012 |
Initial posaconazole prophylactic dosing and serum levels in heart transplant patients.
Topics: Adult; Aged; Antifungal Agents; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Heart Transplantation; Humans; Male; Middle Aged; Retrospective Studies; Surgical Wound Infection; Treatment Outcome; Triazoles | 2012 |
Successful treatment of pulmonary rhizopus infection with surgical resection and posaconazole in a renal transplant recipient.
Topics: Antifungal Agents; Combined Modality Therapy; Humans; Kidney Transplantation; Male; Middle Aged; Mucormycosis; Postoperative Complications; Remission Induction; Rhizopus; Triazoles | 2013 |
Adapting a global cost-effectiveness model to local country requirements: posaconazole case study.
Topics: Antifungal Agents; Cost-Benefit Analysis; Developed Countries; Drug Therapy, Combination; Fluconazole; Fungi; Humans; Itraconazole; Models, Economic; Mycoses; Triazoles | 2013 |
Cutaneous Microsphaeropsis arundinis infection initially interpreted as squamous cell carcinoma.
Topics: Aged; Antifungal Agents; Carcinoma, Squamous Cell; Dermatomycoses; Diagnosis, Differential; Humans; Male; Mitosporic Fungi; Skin Neoplasms; Treatment Outcome; Triazoles | 2013 |
Liposomal amphotericin B and surgery as successful therapy for pulmonary Lichtheimia corymbifera zygomycosis in a pediatric patient with acute promyelocytic leukemia on antifungal prophylaxis with posaconazole.
Topics: Absidia; Adolescent; Amphotericin B; Antifungal Agents; Female; Humans; Immunocompromised Host; Leukemia, Promyelocytic, Acute; Lung Diseases, Fungal; Mucormycosis; Pneumonectomy; Triazoles | 2013 |
Posaconazole pharmacokinetics in a 2-year-old boy with rhino-cerebral-orbital zygomycosis.
Topics: Administration, Oral; Antifungal Agents; Brain; Child, Preschool; Humans; Male; Nasal Cavity; Orbit; Triazoles; Zygomycosis | 2013 |
In vitro antifungal susceptibility of clinically relevant species belonging to Aspergillus section Flavi.
Topics: Amphotericin B; Antifungal Agents; Aspergillus; Echinocandins; Microbial Sensitivity Tests; Naphthalenes; Phylogeny; Terbinafine; Triazoles | 2013 |
Major variations in Aspergillus fumigatus arising within aspergillomas in chronic pulmonary aspergillosis.
Topics: Adult; Antifungal Agents; Aspergillus fumigatus; Chronic Disease; Female; Genetic Variation; Humans; Itraconazole; Microbial Sensitivity Tests; Microsatellite Repeats; Middle Aged; Molecular Typing; Mycological Typing Techniques; Pulmonary Aspergillosis; Pyrimidines; Triazoles; Voriconazole | 2013 |
In vitro antifungal susceptibility of Cladophialophora carrionii, an agent of human chromoblastomycosis.
Topics: Amphotericin B; Antifungal Agents; Ascomycota; Caspofungin; Chromoblastomycosis; Echinocandins; Lipopeptides; Micafungin; Microbial Sensitivity Tests; Nitriles; Pyridines; Pyrimidines; Triazoles; Voriconazole | 2013 |
Acremonium skin and soft tissue infection in a kidney transplant recipient.
Topics: Acremonium; Administration, Oral; Aged; Antifungal Agents; Dermatomycoses; Drug Administration Schedule; Humans; Immunocompromised Host; Immunosuppressive Agents; Kidney Transplantation; Male; Soft Tissue Infections; Time Factors; Treatment Outcome; Triazoles | 2013 |
Experimental models of disseminated scedosporiosis with cerebral involvement.
Topics: Animals; Antifungal Agents; Blood-Brain Barrier; Brain; Central Nervous System Fungal Infections; Disease Models, Animal; Dose-Response Relationship, Drug; Immunocompromised Host; Magnetic Resonance Imaging; Male; Pyrimidines; Rats; Rats, Sprague-Dawley; Scedosporium; Survival Analysis; Triazoles; Voriconazole | 2013 |
[Hemoptysis complicating bronchopulmonary mucormycosis in a diabetic patient].
Topics: Aged, 80 and over; Amphotericin B; Combined Modality Therapy; Diabetes Mellitus, Type 2; Hemoptysis; Humans; Lung Diseases, Fungal; Male; Mucormycosis; Opportunistic Infections; Pneumonectomy; Triazoles | 2013 |
Successful treatment of rhino-orbital mucormycosis with posaconazole and hyperbaric oxygen therapy.
Topics: Adult; Amphotericin B; Antifungal Agents; Child, Preschool; Combined Modality Therapy; Female; Humans; Hyperbaric Oxygenation; Mucormycosis; Orbital Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Remission Induction; Rhizopus; Tomography, X-Ray Computed; Triazoles | 2013 |
Posaconazole vs fluconazole/itraconazole in the prophylaxis of invasive fungal infections in immunocompromised patients: a cost-effectiveness analysis in Greece.
Topics: Antifungal Agents; Cost-Benefit Analysis; Decision Support Techniques; Fluconazole; Greece; Health Expenditures; Humans; Immunocompromised Host; Itraconazole; Models, Economic; Mycoses; Neutropenia; Triazoles | 2013 |
Severe disseminated phaeohyphomycosis in an immunocompetent patient caused by Veronaea botryosa.
Topics: Adult; Antifungal Agents; Ascomycota; DNA, Fungal; DNA, Ribosomal Spacer; Female; Histocytochemistry; Humans; Mexico; Phaeohyphomycosis; Pregnancy; Sequence Analysis, DNA; Skin; Treatment Outcome; Triazoles | 2013 |
Posaconazole exhibits in vitro and in vivo synergistic antifungal activity with caspofungin or FK506 against Candida albicans.
Topics: Animals; Antifungal Agents; Base Sequence; Candida albicans; Candidiasis; Caspofungin; Drug Resistance, Fungal; Drug Synergism; Echinocandins; Ergosterol; Lipopeptides; Male; Mice; Molecular Sequence Data; Mutation; Sequence Homology, Nucleic Acid; Tacrolimus; Triazoles | 2013 |
Pharmacoeconomic evaluation of fluconazole, posaconazole and voriconazole for antifungal prophylaxis in patients with acute myeloid leukaemia undergoing first consolidation chemotherapy.
Topics: Adolescent; Adult; Aged; Antifungal Agents; Chemoprevention; Consolidation Chemotherapy; Economics, Pharmaceutical; Female; Fluconazole; Humans; Immunocompromised Host; Leukemia, Myeloid, Acute; Male; Middle Aged; Mycoses; Pyrimidines; Retrospective Studies; Treatment Outcome; Triazoles; Voriconazole; Young Adult | 2013 |
Candida nivariensis as an etiologic agent of vulvovaginal candidiasis in a tertiary care hospital of New Delhi, India.
Topics: Adult; Amphotericin B; Antifungal Agents; Candida; Candidiasis, Vulvovaginal; DNA, Fungal; Drug Resistance, Fungal; Echinocandins; Female; Fluconazole; Genotype; Humans; India; Itraconazole; Microbial Sensitivity Tests; Nitriles; Phenotype; Phylogeny; Polymerase Chain Reaction; Pyridines; Pyrimidines; Sequence Analysis, DNA; Tertiary Care Centers; Triazoles; Voriconazole; Young Adult | 2013 |
Cost-effectiveness of primary antifungal prophylaxis with posaconazole versus itraconazole in allogeneic hematopoietic stem cell transplantation.
Topics: Antifungal Agents; Cancer Care Facilities; Confidence Intervals; Cost-Benefit Analysis; Fluconazole; Health Resources; Hematopoietic Stem Cell Transplantation; Humans; Itraconazole; Observational Studies as Topic; Spain; Triazoles | 2013 |
Lobomycosis successfully treated with posaconazole.
Topics: Adult; Chronic Disease; Follow-Up Studies; Humans; Lacazia; Lobomycosis; Male; Peru; Recurrence; Treatment Outcome; Triazoles | 2013 |
In vitro antifungal susceptibility and molecular identity of 99 clinical isolates of the opportunistic fungal genus Curvularia.
Topics: Amphotericin B; Antifungal Agents; Ascomycota; Drug Resistance, Multiple, Fungal; Echinocandins; Humans; Itraconazole; Microbial Sensitivity Tests; Phylogeny; Pyrimidines; Triazoles; Voriconazole | 2013 |
Drug combinations against Mucor irregularis in vitro.
Topics: Amphotericin B; Antifungal Agents; Caspofungin; Drug Combinations; Drug Synergism; Echinocandins; Itraconazole; Lipopeptides; Microbial Sensitivity Tests; Mucor; Mucormycosis; Naphthalenes; Terbinafine; Triazoles | 2013 |
First case of Tritirachium oryzae as agent of onychomycosis and its susceptibility to antifungal drugs.
Topics: Adult; Antifungal Agents; Basidiomycota; DNA, Fungal; DNA, Ribosomal Spacer; Female; Humans; Iran; Itraconazole; Microbial Sensitivity Tests; Microbiological Techniques; Microscopy; Molecular Sequence Data; Nails; Onychomycosis; Sequence Analysis, DNA; Triazoles | 2013 |
Antifungal Azoles: Structural Insights into Undesired Tight Binding to Cholesterol-Metabolizing CYP46A1.
Topics: Antifungal Agents; Azoles; Binding Sites; Cholesterol; Cholesterol 24-Hydroxylase; Clotrimazole; Crystallography, X-Ray; Cytochrome P-450 Enzyme System; Humans; Protein Binding; Pyrimidines; Steroid Hydroxylases; Sterol 14-Demethylase; Triazoles; Voriconazole | 2013 |
No effect of antifungal compounds on functional properties of human antifungal T-helper type 1 cells.
Topics: Antifungal Agents; Cells, Cultured; Hematopoietic Stem Cell Transplantation; Humans; Interferon-gamma; Lymphocyte Activation; Mycoses; Th1 Cells; Triazoles; Tumor Necrosis Factor-alpha | 2013 |
Efficacy of liposomal amphotericin B and posaconazole in intratracheal models of murine mucormycosis.
Topics: Amphotericin B; Animals; Antifungal Agents; Cortisone; Cyclophosphamide; Diabetic Ketoacidosis; Disease Models, Animal; Male; Mice; Mice, Inbred ICR; Mice, Inbred NOD; Microbial Sensitivity Tests; Mucorales; Mucormycosis; Triazoles | 2013 |
cyp51A-Based mechanisms of Aspergillus fumigatus azole drug resistance present in clinical samples from Germany.
Topics: Alleles; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Cytochrome P-450 Enzyme System; Drug Resistance, Fungal; Fungal Proteins; Germany; Humans; Itraconazole; Microbial Sensitivity Tests; Mutation; Prevalence; Pyrimidines; Triazoles; Voriconazole | 2013 |
Mitochondrial respiratory pathways inhibition in Rhizopus oryzae potentiates activity of posaconazole and itraconazole via apoptosis.
Topics: Antifungal Agents; Antimycin A; Apoptosis; Caspases; Cytochromes c; DNA Fragmentation; DNA, Fungal; Drug Synergism; Electron Transport; Fungal Proteins; Hydroxamic Acids; Itraconazole; Membrane Potential, Mitochondrial; Microbial Sensitivity Tests; Mitochondria; Reactive Oxygen Species; Rhizopus; Triazoles | 2013 |
Posaconazole prophylaxis--impact on incidence of invasive fungal disease and antifungal treatment in haematological patients.
Topics: Adolescent; Adult; Aged; Antifungal Agents; Chemoprevention; Female; Hematologic Neoplasms; Humans; Immunocompromised Host; Incidence; Male; Middle Aged; Mycoses; Retrospective Studies; Triazoles; Young Adult | 2013 |
Combined antifungal approach for the treatment of invasive mucormycosis in patients with hematologic diseases: a report from the SEIFEM and FUNGISCOPE registries.
Topics: Amphotericin B; Antifungal Agents; Drug Therapy, Combination; Follow-Up Studies; Hematologic Diseases; Humans; Mucormycosis; Registries; Treatment Outcome; Triazoles | 2013 |
In vitro and in vivo studies of the antiparasitic activity of sterol 14α-demethylase (CYP51) inhibitor VNI against drug-resistant strains of Trypanosoma cruzi.
Topics: 14-alpha Demethylase Inhibitors; Animals; Chagas Disease; Drug Resistance; Endoplasmic Reticulum; Golgi Apparatus; Imidazoles; Male; Mice; Microscopy, Electron, Transmission; Nitroimidazoles; Oxadiazoles; Protozoan Proteins; Sterol 14-Demethylase; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
Treatment cost development of patients undergoing remission induction chemotherapy: a pharmacoeconomic analysis before and after introduction of posaconazole prophylaxis.
Topics: Adolescent; Adult; Antifungal Agents; Chemoprevention; Cost-Benefit Analysis; Economics, Pharmaceutical; Female; Health Care Costs; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Mycoses; Remission Induction; Retrospective Studies; Triazoles; Young Adult | 2014 |
Hyperthermia sensitizes Rhizopus oryzae to posaconazole and itraconazole action through apoptosis.
Topics: Acetylcysteine; Amphotericin B; Antifungal Agents; Apoptosis; Caspases; Free Radical Scavengers; Hot Temperature; Humans; Itraconazole; Membrane Potentials; Microbial Sensitivity Tests; Phosphatidylserines; Reactive Oxygen Species; Rhizopus; Triazoles | 2013 |
Efficacy of intrathecal liposomal amphotericin B plus oral posaconazole in the treatment of acute meningeal cryptococcosis in a murine model.
Topics: Amphotericin B; Animals; Cryptococcus neoformans; Drug Resistance, Bacterial; Drug Therapy, Combination; Male; Meningitis, Cryptococcal; Mice; Survival; Treatment Outcome; Triazoles | 2013 |
The calcineurin pathway inhibitor tacrolimus enhances the in vitro activity of azoles against Mucorales via apoptosis.
Topics: Antifungal Agents; Apoptosis; Calcineurin Inhibitors; Dose-Response Relationship, Drug; Itraconazole; Mucorales; Tacrolimus; Triazoles | 2013 |
In vitro activity of miltefosine as a single agent and in combination with voriconazole or posaconazole against uncommon filamentous fungal pathogens.
Topics: Antifungal Agents; Drug Synergism; Fungi; Humans; Microbial Sensitivity Tests; Mycoses; Phosphorylcholine; Pyrimidines; Triazoles; Voriconazole | 2013 |
Head-to-head comparison of inhibitory and fungicidal activities of fluconazole, itraconazole, voriconazole, posaconazole, and isavuconazole against clinical isolates of Trichosporon asahii.
Topics: Antifungal Agents; Fluconazole; Itraconazole; Microbial Sensitivity Tests; Nitriles; Pyridines; Pyrimidines; Triazoles; Trichosporon; Voriconazole | 2013 |
Posaconazole concentrations after allogeneic hematopoietic stem cell transplantation.
Topics: Adult; Aged; Antifungal Agents; Aspergillosis; Female; Hematopoietic Stem Cell Transplantation; Humans; Male; Middle Aged; Mycoses; Retrospective Studies; Triazoles; Young Adult | 2013 |
Dried blood spot analysis suitable for therapeutic drug monitoring of voriconazole, fluconazole, and posaconazole.
Topics: Adult; Aged; Antifungal Agents; Aspergillosis; Dried Blood Spot Testing; Drug Monitoring; Fluconazole; Humans; Middle Aged; Mucormycosis; Mycoses; Triazoles; Young Adult | 2013 |
Pharmacokinetics of posaconazole within epithelial cells and fungi: insights into potential mechanisms of action during treatment and prophylaxis.
Topics: Antibiotic Prophylaxis; Antifungal Agents; Aspergillus fumigatus; Biological Transport; Cell Line; Cell Membrane; Epithelial Cells; Fungi; Humans; Mycoses; Protein Binding; Spores, Fungal; Triazoles | 2013 |
Posaconazole treatment in Korea: single-center experience over 5 years.
Topics: Adult; Aged; Antifungal Agents; Female; Humans; Immunocompromised Host; Male; Middle Aged; Mucormycosis; Mycoses; Republic of Korea; Salvage Therapy; Triazoles | 2013 |
Impact of in vivo triazole and echinocandin combination therapy for invasive pulmonary aspergillosis: enhanced efficacy against Cyp51 mutant isolates.
Topics: Animals; Antifungal Agents; Area Under Curve; Aspergillus fumigatus; Caspofungin; Dose-Response Relationship, Drug; Drug Resistance, Fungal; Drug Synergism; Drug Therapy, Combination; Echinocandins; Female; Humans; Invasive Pulmonary Aspergillosis; Lipopeptides; Mice; Microbial Sensitivity Tests; Spores, Fungal; Triazoles | 2013 |
Benznidazole and posaconazole in experimental Chagas disease: positive interaction in concomitant and sequential treatments.
Topics: Animals; Antiprotozoal Agents; Chagas Disease; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Female; Mice; Nitroimidazoles; Parasitemia; Treatment Outcome; Triazoles; Trypanosoma cruzi | 2013 |
Iatrogenic Cushing's syndrome induced by posaconazole.
Topics: Androstadienes; Antifungal Agents; Aspergillosis; Bronchi; Bronchodilator Agents; Common Variable Immunodeficiency; Cushing Syndrome; Female; Fluticasone; Humans; Iatrogenic Disease; Itraconazole; Middle Aged; Triazoles | 2013 |
Rapid identification of antifungal compounds against Exserohilum rostratum using high throughput drug repurposing screens.
Topics: Adenosine Triphosphate; Amphotericin B; Antifungal Agents; Ascomycota; Bithionol; Cell Line, Tumor; Drug Evaluation, Preclinical; Drug Repositioning; Floxuridine; Humans; Hyphae; Sepsis; Spores, Fungal; Tacrolimus; Triazoles | 2013 |
Molecular dynamics of the supercooled pharmaceutical agent posaconazole studied via differential scanning calorimetry and dielectric and mechanical spectroscopies.
Topics: Calorimetry, Differential Scanning; Molecular Dynamics Simulation; Spectrum Analysis; Triazoles | 2013 |
In vitro susceptibility of Aspergillus fumigatus to isavuconazole: correlation with itraconazole, voriconazole, and posaconazole.
Topics: Amino Acid Substitution; Amphotericin B; Antifungal Agents; Aspergillus fumigatus; Cytochrome P-450 Enzyme System; Drug Resistance, Fungal; Fungal Proteins; Humans; Itraconazole; Microbial Sensitivity Tests; Mutation; Nitriles; Pyridines; Pyrimidines; Triazoles; Voriconazole | 2013 |
Complexes of Trypanosoma cruzi sterol 14α-demethylase (CYP51) with two pyridine-based drug candidates for Chagas disease: structural basis for pathogen selectivity.
Topics: 14-alpha Demethylase Inhibitors; Antiprotozoal Agents; Chagas Disease; Crystallography, X-Ray; Humans; Protozoan Proteins; Sterol 14-Demethylase; Thiazoles; Triazoles; Trypanosoma cruzi | 2013 |
Antifungal prophylaxis with posaconazole in patients with acute myeloid leukemia: dose intensification coupled with avoidance of proton pump inhibitors is beneficial in shortening time to effective concentrations.
Topics: Adult; Aged; Antifungal Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Monitoring; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Mycoses; Proton Pump Inhibitors; Retrospective Studies; Triazoles | 2013 |
Prevention of invasive fungal infections in patients with acute myeloid leukaemia: results of a single centre retrospective observational study with the use of posaconazole versus conventional mould-active azoles.
Topics: Administration, Oral; Adolescent; Adult; Aged; Antifungal Agents; Cohort Studies; Female; Humans; Itraconazole; Leukemia, Myeloid, Acute; Male; Middle Aged; Mycoses; Retrospective Studies; Triazoles; Young Adult | 2014 |
Invasive mucormycosis without radiological alterations.
Topics: Adolescent; Amphotericin B; Antifungal Agents; Female; Fungi; Humans; Liposomes; Mucormycosis; Neutropenia; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Remission Induction; Stem Cell Transplantation; Tomography, X-Ray Computed; Triazoles | 2013 |
Evaluation of the efficacies of Amphotericin B, Posaconazole, Voriconazole, and Anidulafungin in a murine disseminated infection by the emerging opportunistic Fungus Sarocladium (Acremonium) kiliense.
Topics: Acremonium; Amphotericin B; Anidulafungin; Animals; Antifungal Agents; Echinocandins; Male; Mice; Mycoses; Pyrimidines; Triazoles; Voriconazole | 2013 |
In vitro activities of eight antifungal drugs against 106 waterborne and cutaneous exophiala species.
Topics: Amphotericin B; Antifungal Agents; Caspofungin; Echinocandins; Exophiala; Fluconazole; Itraconazole; Lipopeptides; Micafungin; Microbial Sensitivity Tests; Nitriles; Pyridines; Pyrimidines; Triazoles; Voriconazole | 2013 |
Invasive Aspergillus niger complex infections in a Belgian tertiary care hospital.
Topics: Adult; Aged; Aged, 80 and over; Antifungal Agents; Aspergillosis; Aspergillus niger; Belgium; Female; Humans; Incidence; Itraconazole; Male; Microbial Sensitivity Tests; Middle Aged; Molecular Typing; Mycological Typing Techniques; Retrospective Studies; Tertiary Care Centers; Triazoles; Voriconazole | 2014 |
Scedosporium prolificans fungaemia in a patient with acute lymphoblastic leukaemia.
Topics: Allografts; Amphotericin B; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Drug Substitution; Fatal Outcome; Female; Fluconazole; Fungemia; Graft vs Host Disease; Humans; Immunocompromised Host; Immunosuppressive Agents; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Scedosporium; Triazoles; Voriconazole; Young Adult | 2013 |
Breakthrough Fusarium solani infection in a patient with acute myeloid leukemia receiving posaconazole prophylaxis.
Topics: Amphotericin B; Anti-Bacterial Agents; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Drug Resistance, Fungal; Fatal Outcome; Female; Fever; Fusariosis; Fusarium; Humans; Idarubicin; Leukemia, Myeloid, Acute; Triazoles; Young Adult | 2014 |
A reference laboratory experience of clinically achievable voriconazole, posaconazole, and itraconazole concentrations within the bloodstream and cerebral spinal fluid.
Topics: Antifungal Agents; Humans; Itraconazole; Pyrimidines; Triazoles; Voriconazole | 2014 |
Azole-based chemoprophylaxis of invasive fungal infections in paediatric patients with acute leukaemia: an internal audit.
Topics: Adolescent; Antifungal Agents; Chemoprevention; Child; Child, Preschool; Cohort Studies; Female; Humans; Infant; Leukemia; Male; Mycoses; Retrospective Studies; Treatment Outcome; Triazoles; Voriconazole | 2014 |
In vitro evaluation of antifungal drug combinations against Sarocladium (Acremonium) kiliense, an opportunistic emergent fungus resistant to antifungal therapies.
Topics: Acremonium; Amphotericin B; Anidulafungin; Antifungal Agents; Drug Combinations; Drug Interactions; Drug Resistance, Fungal; Echinocandins; Humans; Microbial Sensitivity Tests; Naphthalenes; Pyrimidines; Terbinafine; Triazoles; Voriconazole | 2014 |
[Pulmonary mucormycosis: report of 5 cases and review of 46 cases reported in China].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amphotericin B; Antifungal Agents; Biopsy, Needle; Bronchoscopy; Drug Therapy, Combination; Female; Humans; Lung; Lung Diseases, Fungal; Male; Middle Aged; Mucormycosis; Risk Factors; Tomography, X-Ray Computed; Triazoles; Young Adult | 2013 |
Therapeutic efficacy of posaconazole in a murine model of disseminated trichosporonosis.
Topics: Administration, Oral; Amphotericin B; Animals; Antifungal Agents; Colony Count, Microbial; Fluconazole; Injections, Intraperitoneal; Kidney; Liver; Male; Mice; Mice, Inbred BALB C; Spleen; Treatment Outcome; Triazoles; Trichosporon; Trichosporonosis | 2014 |
Incidence density of invasive fungal infections during primary antifungal prophylaxis in newly diagnosed acute myeloid leukemia patients in a tertiary cancer center, 2009 to 2011.
Topics: Adult; Aged; Aged, 80 and over; Antifungal Agents; Antineoplastic Agents; Echinocandins; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Mycoses; Pyrimidines; Remission Induction; Retrospective Studies; Secondary Prevention; Tertiary Care Centers; Triazoles; Voriconazole | 2014 |
Molecular identification and antifungal susceptibility of yeast isolates causing fungemia collected in a population-based study in Spain in 2010 and 2011.
Topics: Antifungal Agents; Candida; Candida albicans; Candida glabrata; Candida tropicalis; Candidiasis; Drug Resistance, Fungal; Echinocandins; Fungemia; Humans; Itraconazole; Ketoconazole; Microbial Sensitivity Tests; Pyrimidines; Spain; Triazoles; Voriconazole | 2014 |
In vitro activity of the antifungal azoles itraconazole and posaconazole against Leishmania amazonensis.
Topics: Antifungal Agents; Antiprotozoal Agents; Drug Repositioning; Enzyme Inhibitors; Inhibitory Concentration 50; Itraconazole; Leishmania mexicana; Life Cycle Stages; Membrane Potential, Mitochondrial; Microscopy, Electron, Transmission; Mitochondria; Protozoan Proteins; Sterol 14-Demethylase; Triazoles | 2013 |
Refractory invasive aspergillosis controlled with posaconazole and pulmonary surgery in a patient with chronic granulomatous disease: case report.
Topics: Antifungal Agents; Aspergillosis; Child, Preschool; Diagnosis, Differential; Follow-Up Studies; Granulomatous Disease, Chronic; Humans; Immunocompromised Host; Male; Pneumonectomy; Tomography, X-Ray Computed; Triazoles | 2014 |
Multilaboratory study of epidemiological cutoff values for detection of resistance in eight Candida species to fluconazole, posaconazole, and voriconazole.
Topics: Antifungal Agents; Candida; Fluconazole; Microbial Sensitivity Tests; Pyrimidines; Triazoles; Voriconazole | 2014 |
Reverse halo sign in pulmonary mucormyosis.
Topics: Amphotericin B; Antifungal Agents; Biopsy, Fine-Needle; Humans; Image-Guided Biopsy; Immunocompromised Host; Leukemia, Myeloid, Acute; Male; Middle Aged; Mucormycosis; Multiple Pulmonary Nodules; Tomography, X-Ray Computed; Treatment Outcome; Triazoles | 2014 |
Impact of calibrator concentrations and their distribution on accuracy of quadratic regression for liquid chromatography-mass spectrometry bioanalysis.
Topics: Calibration; Chromatography, Liquid; Humans; Mass Spectrometry; Quality Control; Retrospective Studies; Triazoles | 2014 |
Intrapulmonary posaconazole penetration at the infection site in an immunosuppressed murine model of invasive pulmonary aspergillosis receiving oral prophylactic regimens.
Topics: Administration, Oral; Animals; Antifungal Agents; Disease Models, Animal; Female; Invasive Pulmonary Aspergillosis; Mice; Triazoles | 2014 |
Effectiveness of primary anti-Aspergillus prophylaxis during remission induction chemotherapy of acute myeloid leukemia.
Topics: Aged; Antifungal Agents; Aspergillus; Echinocandins; Female; Humans; Induction Chemotherapy; Leukemia, Myeloid, Acute; Male; Middle Aged; Retrospective Studies; Risk Factors; Triazoles; Voriconazole | 2014 |
Histopathological evidence of invasive gastric mucormycosis after transarterial chemoembolization and liver transplantation.
Topics: Amphotericin B; Antifungal Agents; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Diabetes Complications; Female; Hepatitis B, Chronic; Histocytochemistry; Humans; Immunocompromised Host; Immunosuppressive Agents; Liver Neoplasms; Liver Transplantation; Microscopy; Middle Aged; Mucorales; Mucormycosis; Stomach Diseases; Triazoles | 2014 |
Colonic basidiobolomycosis in a child: report of a culture-proven case.
Topics: Antifungal Agents; Child, Preschool; Colon; Entomophthorales; Humans; Male; Treatment Outcome; Triazoles; Zygomycosis | 2014 |
Factors influencing posaconazole plasmatic concentrations in patients presenting with acute myeloid leukemia.
Topics: Adult; Aged; Antifungal Agents; Aspergillosis; Drug Monitoring; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Retrospective Studies; Triazoles; Young Adult | 2014 |
Understanding antifungal prophylaxis with posaconazole in hematology patients: an evolving bedside to bench story.
Topics: Antifungal Agents; Chemoprevention; Hematologic Diseases; Humans; Mycoses; Triazoles | 2014 |
Azole-resistant Aspergillus fumigatus in the environment of northern Italy, May 2011 to June 2012.
Topics: Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Humans; Italy; Itraconazole; Microbial Sensitivity Tests; Mutation; Polymerase Chain Reaction; Sentinel Surveillance; Soil Microbiology; Triazoles | 2014 |
Posaconazole tablet pharmacokinetics: lack of effect of concomitant medications altering gastric pH and gastric motility in healthy subjects.
Topics: Adult; Antacids; Antifungal Agents; Area Under Curve; Drug Interactions; Female; Gastric Acid; Gastrointestinal Motility; Healthy Volunteers; Histamine H1 Antagonists; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Proton Pump Inhibitors; Tablets; Triazoles; Young Adult | 2014 |
Economic evaluation of posaconazole versus fluconazole or itraconazole in the prevention of invasive fungal infection in high-risk neutropenic patients in Sweden.
Topics: Aged; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials, Phase III as Topic; Cost-Benefit Analysis; Female; Fluconazole; Humans; Itraconazole; Leukemia, Myeloid, Acute; Life Expectancy; Male; Middle Aged; Mycoses; Myelodysplastic Syndromes; Neutropenia; Quality of Life; Quality-Adjusted Life Years; Sweden; Triazoles | 2014 |
Advancing the treatment for Chagas' disease.
Topics: Chagas Disease; Female; Humans; Male; Nitroimidazoles; Triazoles; Trypanocidal Agents | 2014 |
Does fungicide application in vineyards induce resistance to medical azoles in Aspergillus species?
Topics: Adaptation, Physiological; Agriculture; Antifungal Agents; Aspergillus; Azoles; Environmental Monitoring; Fungicides, Industrial; Humans; Itraconazole; Microbial Sensitivity Tests; Portugal; Pyrimidines; Triazoles; Voriconazole; Wine | 2014 |
Alopecia and nail changes associated with voriconazole therapy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alopecia; Antifungal Agents; Cross-Sectional Studies; Disease Outbreaks; Female; Humans; Male; Methylprednisolone; Michigan; Middle Aged; Mycoses; Nails; Prevalence; Triazoles; Voriconazole | 2014 |
Successful treatment of Paecilomyces lilacinus keratitis with oral posaconazole.
Topics: Administration, Oral; Antifungal Agents; Corneal Ulcer; Eye Infections, Fungal; Humans; Male; Middle Aged; Mycoses; Paecilomyces; Triazoles | 2014 |
Breakthrough invasive fungal disease in patients receiving posaconazole primary prophylaxis: a 4-year study.
Topics: Adult; Aged; Aged, 80 and over; Antifungal Agents; Chemoprevention; Drug Resistance, Fungal; Female; France; Humans; Immunocompromised Host; Incidence; Male; Middle Aged; Mycoses; Retrospective Studies; Triazoles; Young Adult | 2014 |
Posaconazole concentrations in human tissues after allogeneic stem cell transplantation.
Topics: Antifungal Agents; Autopsy; Brain Chemistry; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Kidney; Liver; Lung; Mycoses; Myocardium; Transplantation, Homologous; Triazoles | 2014 |
Studies on the antileishmanial mechanism of action of the arylimidamide DB766: azole interactions and role of CYP5122A1.
Topics: Amidines; Animals; Antiprotozoal Agents; Axenic Culture; Blotting, Western; Cricetinae; Drug Combinations; Drug Resistance; Drug Synergism; Furans; Gene Expression Regulation; Ketoconazole; Leishmania donovani; Life Cycle Stages; Mice; Phosphorylcholine; Protozoan Proteins; Sterol 14-Demethylase; Triazoles | 2014 |
Dosing algorithm for concomitant administration of sirolimus, tacrolimus, and an azole after allogeneic hematopoietic stem cell transplantation.
Topics: Adult; Aged; Algorithms; Antifungal Agents; Azoles; Drug Dosage Calculations; Female; Fluconazole; Hematologic Neoplasms; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Male; Middle Aged; Mycoses; Retrospective Studies; Sirolimus; Tacrolimus; Triazoles; Voriconazole; Young Adult | 2015 |
Posaconazole responsive cerebral aspergillosis in an immunocompetent adult.
Topics: Aged; Antifungal Agents; Aspergillosis; Brain; Encephalitis; Humans; Magnetic Resonance Imaging; Male; Suction; Treatment Outcome; Triazoles; Voriconazole | 2014 |
Experimental treatment of Curvularia infection.
Topics: Amphotericin B; Animals; Antifungal Agents; Ascomycota; Disease Models, Animal; Immunocompromised Host; Male; Mice; Mycoses; Treatment Outcome; Triazoles; Voriconazole | 2014 |
Treatment and outcomes of invasive fusariosis: review of 65 cases from the PATH Alliance(®) registry.
Topics: Adult; Aged; Aged, 80 and over; Antifungal Agents; Canada; Female; Fusariosis; Fusarium; Humans; Male; Middle Aged; Prospective Studies; Registries; Survival Analysis; Treatment Outcome; Triazoles; United States; Voriconazole; Young Adult | 2014 |
Malassezia pachydermatis fungaemia in an adult on posaconazole prophylaxis for acute myeloid leukaemia.
Topics: Aged; Antifungal Agents; Fungemia; Humans; Immunocompromised Host; Leukemia, Myeloid, Acute; Malassezia; Male; Mycoses; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Superinfection; Triazoles | 2014 |
Cysticidal activity of antifungals against different genotypes of Acanthamoeba.
Topics: Acanthamoeba; Acanthamoeba Keratitis; Amebiasis; Antifungal Agents; Cysts; Humans; Parasitic Sensitivity Tests; Triazoles; Voriconazole | 2014 |
Posaconazole prophylaxis in neutropenic patients with hematological malignancies: limits in clinical practice.
Topics: Administration, Oral; Adolescent; Adult; Aged; Antifungal Agents; Chemoprevention; Child; Drug-Related Side Effects and Adverse Reactions; Female; Hematologic Neoplasms; Humans; Incidence; Male; Middle Aged; Mycoses; Plasma; Prospective Studies; Treatment Outcome; Triazoles; Withholding Treatment; Young Adult | 2014 |
Synergy testing of FDA-approved drugs identifies potent drug combinations against Trypanosoma cruzi.
Topics: Animals; Clemastine; Drug Combinations; Drug Synergism; Female; Mice; Mice, Inbred BALB C; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
Experimental therapy with azoles against Candida guilliermondii.
Topics: Antifungal Agents; Azoles; Candida; Microbial Sensitivity Tests; Triazoles; Voriconazole | 2014 |
Efficacy of anti-fungal but not anti-bacterial prophylaxis in intensive primary AML therapy: a real-world, retrospective comparative single-centre study.
Topics: Anti-Bacterial Agents; Antibiotic Prophylaxis; Antifungal Agents; Antineoplastic Agents; Bacteremia; Disease-Free Survival; Female; Hematopoietic Stem Cell Transplantation; Humans; Leukemia, Myeloid, Acute; Levofloxacin; Male; Middle Aged; Mycoses; Retrospective Studies; Survival Rate; Triazoles | 2014 |
Impact of structured personal on-site patient education on low posaconazole plasma concentrations in patients with haematological malignancies.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antifungal Agents; Austria; Chemoprevention; Cohort Studies; Drug Monitoring; Female; Hematologic Neoplasms; Humans; Male; Medication Adherence; Middle Aged; Mycoses; Patient Education as Topic; Plasma; Triazoles; Young Adult | 2014 |
Efficacy of PTX3 and posaconazole combination in a rat model of invasive pulmonary aspergillosis.
Topics: Animals; Antifungal Agents; C-Reactive Protein; Drug Synergism; Invasive Pulmonary Aspergillosis; Male; Rats; Serum Amyloid P-Component; Triazoles | 2014 |
Cryptic and rare Aspergillus species in Brazil: prevalence in clinical samples and in vitro susceptibility to triazoles.
Topics: Antifungal Agents; Aspergillosis; Aspergillus; Brazil; Calmodulin; Cluster Analysis; DNA, Fungal; DNA, Ribosomal Spacer; Humans; Itraconazole; Microbial Sensitivity Tests; Molecular Sequence Data; Phylogeny; Prevalence; Sequence Analysis, DNA; Triazoles; Tubulin; Voriconazole | 2014 |
[Cutaneous mucormycosis as a rare complication of a liver transplantation].
Topics: Abdominal Wall; Acute Kidney Injury; Adult; Amphotericin B; Anti-Infective Agents; Antibiotic Prophylaxis; Antifungal Agents; Clostridium Infections; Cytomegalovirus Infections; Debridement; Dermatomycoses; Hepatitis; Humans; Immunosuppressive Agents; Liver Transplantation; Male; Mucormycosis; Opportunistic Infections; Postoperative Complications; Primary Graft Dysfunction; Reoperation; Triazoles | 2014 |
Primary antifungal prophylaxis with micafungin in patients with haematological malignancies: real-life data from a retrospective single-centre observational study.
Topics: Adult; Aged; Amphotericin B; Antifungal Agents; Candida; Candidiasis; Drug Administration Schedule; Echinocandins; Female; Hematologic Neoplasms; Hematopoietic Stem Cell Transplantation; Humans; Injections, Intravenous; Lipopeptides; Male; Micafungin; Middle Aged; Retrospective Studies; Transplantation, Homologous; Triazoles; Trichosporon; Trichosporonosis | 2015 |
Posaconazole salvage treatment for invasive fungal infection.
Topics: Adult; Aged; Antifungal Agents; Byssochlamys; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Middle Aged; Mucor; Mycoses; Retrospective Studies; Salvage Therapy; Survival Analysis; Time Factors; Treatment Outcome; Triazoles; Withholding Treatment | 2014 |
Invasive cardiac aspergillosis after orthotopic liver transplantation.
Topics: Acute Disease; Caspofungin; Drug Therapy, Combination; Echinocandins; Echocardiography, Transesophageal; Hepatitis B; Humans; Lipopeptides; Liver Failure; Liver Transplantation; Lung; Magnetic Resonance Imaging; Male; Middle Aged; Myocarditis; Myocardium; Opportunistic Infections; Postoperative Complications; Pulmonary Aspergillosis; Triazoles | 2014 |
Aspergillus fumigatus harbouring the sole Y121F mutation shows decreased susceptibility to voriconazole but maintained susceptibility to itraconazole and posaconazole.
Topics: Antifungal Agents; Aspergillus fumigatus; Cytochrome P-450 Enzyme System; DNA, Fungal; Drug Resistance, Fungal; Fungal Proteins; Itraconazole; Molecular Sequence Data; Mutation, Missense; Sequence Analysis, DNA; Triazoles; Voriconazole | 2014 |
Environmental azole fungicide, prochloraz, can induce cross-resistance to medical triazoles in Candida glabrata.
Topics: Antifungal Agents; ATP-Binding Cassette Transporters; Candida glabrata; Cytochrome P-450 Enzyme System; Drug Resistance, Fungal; Fluconazole; Fungicides, Industrial; Imidazoles; Microbial Sensitivity Tests; Transcription Factors; Triazoles | 2014 |
Hot melt extruded amorphous solid dispersion of posaconazole with improved bioavailability: investigating drug-polymer miscibility with advanced characterisation.
Topics: Animals; Biological Availability; Calorimetry, Differential Scanning; Drug Stability; Hot Temperature; Humans; Male; Microscopy, Atomic Force; Molecular Dynamics Simulation; Polymers; Rats, Wistar; Solubility; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Time Factors; Triazoles; X-Ray Diffraction | 2014 |
Serum galactomannan-based early detection of invasive aspergillosis in hematology patients receiving effective antimold prophylaxis.
Topics: Antifungal Agents; Antigens, Fungal; Aspergillosis; Galactose; Humans; Mannans; Triazoles | 2014 |
Comparative pharmacodynamics of posaconazole in neutropenic murine models of invasive pulmonary aspergillosis and mucormycosis.
Topics: Amphotericin B; Animals; Antifungal Agents; Area Under Curve; Aspergillosis; Aspergillus fumigatus; Benzoates; Caspofungin; Deferasirox; Disease Models, Animal; Drug Therapy, Combination; Echinocandins; Female; Invasive Pulmonary Aspergillosis; Lipopeptides; Lung; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Mucormycosis; Neutropenia; Rhizopus; Treatment Outcome; Triazoles | 2014 |
Clinical challenge: fatal mucormycotic osteomyelitis caused by Rhizopus microsporus despite aggressive multimodal treatment.
Topics: Aged; Amphotericin B; Antifungal Agents; Bone Marrow Transplantation; Combined Modality Therapy; Fatal Outcome; Humans; Male; Mucormycosis; Osteomyelitis; Rhizopus; Triazoles | 2014 |
Switching from posaconazole suspension to tablets increases serum drug levels in leukemia patients without clinically relevant hepatotoxicity.
Topics: Administration, Oral; Adult; Aged; Antifungal Agents; Female; Food-Drug Interactions; Gastrointestinal Absorption; Humans; Leukemia; Liver; Male; Middle Aged; Mycoses; Suspensions; Tablets; Triazoles | 2014 |
Understanding variability in posaconazole exposure using an integrated population pharmacokinetic analysis.
Topics: Adult; Anti-HIV Agents; Anticonvulsants; Antiemetics; Antifungal Agents; Biological Availability; Carbamates; Drug Interactions; Drug Therapy, Combination; Furans; Healthy Volunteers; Humans; Metoclopramide; Nucleic Acid Synthesis Inhibitors; Organophosphates; Phenytoin; Proton Pump Inhibitors; Rifampin; Sulfonamides; Triazoles | 2014 |
Molecular characterization and in vitro antifungal susceptibility of 80 clinical isolates of mucormycetes in Delhi, India.
Topics: Amphotericin B; Amplified Fragment Length Polymorphism Analysis; Antifungal Agents; DNA, Fungal; Drug Resistance, Fungal; Humans; India; Itraconazole; Microbial Sensitivity Tests; Mucor; Mucorales; Mucormycosis; Mycological Typing Techniques; Nitriles; Pyridines; Rhizopus; Sequence Analysis, DNA; Specimen Handling; Triazoles | 2014 |
Disseminated Mucormycosis With Cerebral Involvement Owing to Rhizopus Microsporus in a Kidney Recipient Treated With Combined Liposomal Amphotericin B and Posaconazole Therapy.
Topics: Amphotericin B; Antifungal Agents; Central Nervous System Fungal Infections; Diagnosis, Differential; Drug Therapy, Combination; Fatal Outcome; Humans; Kidney Transplantation; Magnetic Resonance Imaging; Male; Middle Aged; Mucormycosis; Predictive Value of Tests; Rhizopus; Tomography, X-Ray Computed; Treatment Outcome; Triazoles | 2016 |
Last generation triazoles for imported eumycetoma in eleven consecutive adults.
Topics: Adolescent; Adult; Antifungal Agents; beta-Glucans; Child; Exophiala; Fluorodeoxyglucose F18; Fusarium; Humans; Madurella; Magnetic Resonance Imaging; Male; Mycetoma; Positron-Emission Tomography; Proteoglycans; Retrospective Studies; Skin; Treatment Outcome; Triazoles; Voriconazole; Young Adult | 2014 |
Lingual necrosis caused by mucormycosis in a patient with aplastic anaemia: case report.
Topics: Aged, 80 and over; Amphotericin B; Anemia, Aplastic; Antifungal Agents; Escherichia coli Infections; Fatal Outcome; Female; Humans; Immunocompromised Host; Mucormycosis; Necrosis; Rhizopus; Tongue; Triazoles | 2014 |
Case report: Non-invasive management of Madura foot with oral posaconazole and ciprofloxacin.
Topics: Administration, Oral; Adult; Anti-Bacterial Agents; Antifungal Agents; Ciprofloxacin; Drug Therapy, Combination; Humans; Magnetic Resonance Imaging; Male; Mycetoma; Triazoles; Young Adult | 2014 |
Posaconazole treatment of extensive skin and nail dermatophytosis due to autosomal recessive deficiency of CARD9.
Topics: Adult; Biopsy; CARD Signaling Adaptor Proteins; DNA Mutational Analysis; Follow-Up Studies; Genes, Recessive; Humans; Male; Mutation; Nails; Phenotype; Skin; Tinea; Triazoles | 2015 |
Keratitis by Fusarium temperatum, a novel opportunist.
Topics: Amphotericin B; Antifungal Agents; Base Sequence; DNA, Fungal; Echinocandins; Fungal Proteins; Fusarium; Humans; Keratitis; Lipopeptides; Micafungin; Microbial Sensitivity Tests; Molecular Sequence Data; Multilocus Sequence Typing; Mycoses; Phylogeny; Sequence Analysis, DNA; Treatment Outcome; Triazoles; Tubulin; Zea mays | 2014 |
Clinical efficacy and safety of primary antifungal prophylaxis with posaconazole versus fluconazole in allogeneic blood hematopoietic stem cell transplantation recipients-A retrospective analysis of a single medical center in Taiwan.
Topics: Adolescent; Adult; Antibiotic Prophylaxis; Antifungal Agents; Child; Female; Fluconazole; Hematopoietic Stem Cell Transplantation; Humans; Male; Middle Aged; Mycoses; Opportunistic Infections; Retrospective Studies; Taiwan; Treatment Outcome; Triazoles; Young Adult | 2016 |
Keratitis caused by Absidia corymbifera in an immunocompetent male with no corneal injuries.
Topics: Absidia; Administration, Ophthalmic; Adrenal Cortex Hormones; Amphotericin B; Anti-Bacterial Agents; Antifungal Agents; Combined Modality Therapy; Corneal Transplantation; Corneal Ulcer; Drug Therapy, Combination; Humans; Immunocompetence; Male; Middle Aged; Mucormycosis; Ophthalmic Solutions; Staining and Labeling; Triazoles; Voriconazole | 2015 |
Susceptibility profiles of amphotericin B and posaconazole against clinically relevant mucorales species under hypoxic conditions.
Topics: Amphotericin B; Antifungal Agents; Cell Hypoxia; Microbial Sensitivity Tests; Mucorales; Triazoles | 2015 |
Match-making for posaconazole through systems thinking.
Topics: Chagas Disease; Clinical Trials, Phase II as Topic; Drug Therapy, Combination; Humans; Systems Biology; Triazoles; Trypanocidal Agents; Trypanosoma | 2015 |
An update to the cost-effectiveness of posaconazole vs fluconazole or itraconazole in the prevention of invasive fungal disease among neutropenic patients in the United States.
Topics: Antifungal Agents; Cost-Benefit Analysis; Fluconazole; Humans; Itraconazole; Leukemia, Myeloid; Mycoses; Triazoles; United States | 2015 |
Posaconazole prophylaxis in experimental azole-resistant invasive pulmonary aspergillosis.
Topics: Animals; Antifungal Agents; Aspergillus fumigatus; Dose-Response Relationship, Drug; Drug Resistance, Fungal; Female; Invasive Pulmonary Aspergillosis; Mice; Microbial Sensitivity Tests; Triazoles | 2015 |
Therapeutic Drug Monitoring and Dose Adjustment of Posaconazole Oral Suspension in Adults With Acute Myeloid Leukemia.
Topics: Administration, Oral; Adult; Antifungal Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Monitoring; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Triazoles | 2015 |
Proximal subungual onychomycosis caused by Fusarium falciforme successfully cured with posaconazole.
Topics: Antifungal Agents; Foot Dermatoses; Fusariosis; Fusarium; Humans; Male; Middle Aged; Molecular Sequence Data; Onychomycosis; Triazoles | 2015 |
Multicenter evaluation of MIC distributions for epidemiologic cutoff value definition to detect amphotericin B, posaconazole, and itraconazole resistance among the most clinically relevant species of Mucorales.
Topics: Amphotericin B; Antifungal Agents; Drug Resistance, Multiple, Fungal; Humans; Itraconazole; Microbial Sensitivity Tests; Mucorales; Mucormycosis; Triazoles | 2015 |
The strength of synergistic interaction between posaconazole and caspofungin depends on the underlying azole resistance mechanism of Aspergillus fumigatus.
Topics: Antifungal Agents; Aspergillus fumigatus; Azoles; Caspofungin; Drug Resistance, Fungal; Drug Synergism; Echinocandins; Fungal Proteins; Lipopeptides; Tandem Repeat Sequences; Triazoles | 2015 |
SQ109, a new drug lead for Chagas disease.
Topics: Adamantane; Animals; Chagas Disease; Ethylenediamines; Hemolysis; Humans; In Vitro Techniques; LLC-PK1 Cells; Membrane Potential, Mitochondrial; Squalene; Sterols; Swine; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Efficacy of oleylphosphocholine (OlPC) in vitro and in a mouse model of invasive aspergillosis.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus; Aspergillus fumigatus; Azoles; Disease Models, Animal; Mice; Microbial Sensitivity Tests; Phosphorylcholine; Pyrimidines; Triazoles; Voriconazole | 2015 |
Successful long-term management of invasive cerebral fungal infection following liver transplantation.
Topics: Antifungal Agents; Aspergillus; Aspergillus flavus; Brain Diseases; Central Nervous System Fungal Infections; Drug Therapy, Combination; Humans; Liver Transplantation; Male; Middle Aged; Neuroaspergillosis; Radiography; Scedosporium; Triazoles; Voriconazole | 2015 |
Invasive cardiac aspergillosis presenting as complete heart block in a patient with acute lymphoblastic leukaemia.
Topics: Amphotericin B; Antifungal Agents; Aspergillosis; Cardiomyopathies; Electrocardiography; Heart Block; Humans; Male; Middle Aged; Opportunistic Infections; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Triazoles | 2015 |
Antifungal prophylaxis with posaconazole vs. fluconazole or itraconazole in pediatric patients with neutropenia.
Topics: Adolescent; Antifungal Agents; Chemoprevention; Child; Child, Preschool; Cohort Studies; Drug-Related Side Effects and Adverse Reactions; Female; Fluconazole; Humans; Incidence; Infant; Itraconazole; Male; Mycoses; Neoplasms; Neutropenia; Retrospective Studies; Treatment Outcome; Triazoles | 2015 |
In vitro antifungal susceptibilities of isolates of Candida spp. and Aspergillus spp. from China to nine systemically active antifungal agents: data from the SENTRY antifungal surveillance program, 2010 through 2012.
Topics: Amphotericin B; Antifungal Agents; Aspergillus; Azoles; Candida; China; Drug Resistance, Fungal; Drug Resistance, Multiple, Fungal; Echinocandins; Fluconazole; Flucytosine; Humans; Microbial Sensitivity Tests; Mutation; Rhodotorula; Sequence Analysis, DNA; Triazoles; Trichosporon; Voriconazole | 2015 |
Use of posaconazole delayed-release tablets for treatment of invasive aspergillosis.
Topics: Aged; Antifungal Agents; Brain; Brain Abscess; Delayed-Action Preparations; Humans; Male; Neuroaspergillosis; Tablets; Treatment Outcome; Triazoles; Voriconazole | 2015 |
In vitro susceptibility patterns of clinically important Trichophyton and Epidermophyton species against nine antifungal drugs.
Topics: Amphotericin B; Anidulafungin; Antifungal Agents; Caspofungin; Echinocandins; Epidermophyton; Fluconazole; Humans; Itraconazole; Lipopeptides; Microbial Sensitivity Tests; Naphthalenes; Nitriles; Pyridines; Terbinafine; Tinea; Triazoles; Trichophyton; Voriconazole | 2015 |
Muscle diffusion of liposomal amphotericin B and posaconazole in critically ill burn patients receiving continuous hemodialysis.
Topics: Amphotericin B; Antifungal Agents; Burns; Critical Illness; Diffusion; Humans; Liposomes; Mucormycosis; Muscles; Renal Dialysis; Triazoles | 2015 |
Efficacy of antifungal prophylaxis with oral suspension posaconazole during induction chemotherapy of acute myeloid leukemia.
Topics: Administration, Oral; Adult; Aged; Antifungal Agents; Cohort Studies; Female; Humans; Induction Chemotherapy; Leukemia, Myeloid, Acute; Male; Middle Aged; Mycoses; Randomized Controlled Trials as Topic; Retrospective Studies; Suspensions; Triazoles; Young Adult | 2015 |
Posaconazole liquid suspension in solid organ transplant recipients previously treated with voriconazole.
Topics: Antifungal Agents; Female; Hematopoietic Stem Cell Transplantation; Humans; Invasive Pulmonary Aspergillosis; Male; Middle Aged; Mucormycosis; Mycoses; Transplant Recipients; Transplants; Triazoles; Voriconazole | 2015 |
Evaluation of a modified EUCAST fragmented-mycelium inoculum method for in vitro susceptibility testing of dermatophytes and the activity of novel antifungal agents.
Topics: Antifungal Agents; Echinocandins; Microbial Sensitivity Tests; Mycelium; Triazoles; Trichophyton | 2015 |
Decreased invasive fungal disease but no impact on overall survival by posaconazole compared to fluconazole prophylaxis: a retrospective cohort study in patients receiving induction therapy for acute myeloid leukaemia/myelodysplastic syndromes.
Topics: Adult; Aged; Aged, 80 and over; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Daunorubicin; Female; Fluconazole; Humans; Induction Chemotherapy; Leukemia, Myeloid, Acute; Male; Middle Aged; Mycoses; Myelodysplastic Syndromes; Pre-Exposure Prophylaxis; Remission Induction; Retrospective Studies; Survival Analysis; Triazoles | 2016 |
Multi-triazole-resistant Aspergillus fumigatus infections in Australia.
Topics: Adult; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Australia; Cytochrome P-450 Enzyme System; Drug Resistance, Fungal; Female; Fungal Proteins; Humans; Itraconazole; Male; Microbial Sensitivity Tests; Middle Aged; Mutation, Missense; Retrospective Studies; Triazoles; Voriconazole | 2015 |
Breakthrough invasive fungal infection under the use of posaconazole and voriconazole.
Topics: Antifungal Agents; Colletotrichum; Drug Resistance, Multiple, Fungal; Hematopoietic Stem Cell Transplantation; Humans; Invasive Fungal Infections; Lymphoma, T-Cell, Peripheral; Male; Middle Aged; Opportunistic Infections; Triazoles; Voriconazole | 2016 |
Serum posaconazole levels during acute myeloid leukaemia induction therapy: correlations with breakthrough invasive fungal infections.
Topics: Adolescent; Adult; Aged; Antifungal Agents; Antineoplastic Agents; Fungemia; Humans; Incidence; Induction Chemotherapy; Leukemia, Myeloid, Acute; Male; Middle Aged; Serum; Triazoles; Young Adult | 2015 |
Genetic Analysis Using an Isogenic Mating Pair of Aspergillus fumigatus Identifies Azole Resistance Genes and Lack of MAT Locus's Role in Virulence.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Azoles; Crosses, Genetic; Drug Resistance, Multiple, Fungal; Fungal Proteins; Genes, Mating Type, Fungal; Genetic Loci; Hydroxymethylglutaryl CoA Reductases; Itraconazole; Larva; Mice, Inbred BALB C; Microbial Sensitivity Tests; Mixed Function Oxygenases; Moths; Mutation; Sterol 14-Demethylase; Survival Analysis; Triazoles; Virulence; Voriconazole | 2015 |
Suspected posaconazole toxicity in a pediatric oncology patient.
Topics: Adolescent; Anorexia; Antifungal Agents; Combined Modality Therapy; Delayed-Action Preparations; Drug Therapy, Combination; Fatigue; Female; Humans; Hypokalemia; Maxillary Sinus Neoplasms; Medication Errors; Musculoskeletal Pain; Mycoses; Osteosarcoma; Postoperative Complications; Sinusitis; Triazoles | 2015 |
Superior Serum Concentrations with Posaconazole Delayed-Release Tablets Compared to Suspension Formulation in Hematological Malignancies.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibiotic Prophylaxis; Antifungal Agents; Chemistry, Pharmaceutical; Delayed-Action Preparations; Female; Hematologic Neoplasms; Humans; Male; Middle Aged; Mycoses; Suspensions; Tablets; Triazoles; Young Adult | 2015 |
In Vitro and In Vivo Efficacy of Amphotericin B Combined with Posaconazole against Experimental Disseminated Sporotrichosis.
Topics: Amphotericin B; Animals; Antifungal Agents; Drug Resistance, Multiple, Fungal; Drug Therapy, Combination; Mice; Microbial Sensitivity Tests; Sporothrix; Sporotrichosis; Triazoles | 2015 |
Limited Ability of Posaconazole To Cure both Acute and Chronic Trypanosoma cruzi Infections Revealed by Highly Sensitive In Vivo Imaging.
Topics: Animals; Antifungal Agents; Chagas Disease; Chronic Disease; Disease Models, Animal; Female; Mice; Mice, Inbred BALB C; Mice, SCID; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
In Vitro Triple Combination of Antifungal Drugs against Clinical Scopulariopsis and Microascus Species.
Topics: Antifungal Agents; Ascomycota; Caspofungin; Drug Resistance, Multiple, Fungal; Drug Therapy, Combination; Echinocandins; Humans; Lipopeptides; Microbial Sensitivity Tests; Mycoses; Naphthalenes; Scopulariopsis; Terbinafine; Triazoles | 2015 |
Management of drug interaction between posaconazole and sirolimus in patients who undergo hematopoietic stem cell transplant.
Topics: Adult; Aged; Antifungal Agents; Drug Interactions; Female; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Male; Middle Aged; Retrospective Studies; Sirolimus; Triazoles; Young Adult | 2015 |
First determination of azole resistance in Aspergillus fumigatus strains carrying the TR34/L98H mutations in Turkey.
Topics: Adult; Aged; Amphotericin B; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Cytochrome P-450 Enzyme System; DNA Mutational Analysis; Drug Resistance, Fungal; Female; Fungal Proteins; Humans; Itraconazole; Male; Microbial Sensitivity Tests; Middle Aged; Mutation; Promoter Regions, Genetic; Triazoles; Turkey; Voriconazole; Young Adult | 2015 |
Retrospective Comparison of Posaconazole Levels in Patients Taking the Delayed-Release Tablet versus the Oral Suspension.
Topics: Administration, Oral; Adult; Antifungal Agents; Biological Availability; Chemistry, Pharmaceutical; Delayed-Action Preparations; Female; Healthy Volunteers; Humans; Male; Middle Aged; Retrospective Studies; Suspensions; Tablets; Triazoles | 2015 |
Marketed Drugs Can Inhibit Cytochrome P450 27A1, a Potential New Target for Breast Cancer Adjuvant Therapy.
Topics: Adjuvants, Pharmaceutic; Anastrozole; Anilides; Animals; Antifungal Agents; Antineoplastic Agents; Breast Neoplasms; Cholestanetriol 26-Monooxygenase; Dexmedetomidine; Enzyme Inhibitors; Fadrozole; Female; Hypnotics and Sedatives; Mice; Mice, Inbred C57BL; Nitriles; Protein Binding; Thiazoles; Tosyl Compounds; Triazoles | 2015 |
In vitro activities of a wide panel of antifungal drugs against various Scopulariopsis and Microascus species.
Topics: Amphotericin B; Antifungal Agents; Ascomycota; Caspofungin; Drug Resistance, Fungal; Echinocandins; Fluconazole; Flucytosine; Itraconazole; Ketoconazole; Lipopeptides; Microbial Sensitivity Tests; Scopulariopsis; Triazoles; Voriconazole | 2015 |
Serum posaconazole levels among haematological cancer patients taking extended release tablets is affected by body weight and diarrhoea: single centre retrospective analysis.
Topics: Administration, Oral; Adult; Aged; Antifungal Agents; Biological Availability; Body Mass Index; Body Weight; Delayed-Action Preparations; Diarrhea; Female; Hematologic Neoplasms; Humans; Male; Middle Aged; Mycoses; Retrospective Studies; Tablets; Triazoles; Young Adult | 2015 |
Successful Treatment of Primary Cutaneous Mucormycosis Complicating Anti-TNF Therapy with a Combination of Surgical Debridement and Oral Posaconazole.
Topics: Antifungal Agents; Arthritis, Psoriatic; Debridement; Dermatomycoses; Diabetes Complications; Etanercept; Female; Humans; Immunosuppressive Agents; Middle Aged; Mucormycosis; Prednisone; Treatment Outcome; Triazoles; Wounds and Injuries | 2015 |
Paradoxical response preceding control of Scedosporium apiospermum mycetoma with posaconazole treatment.
Topics: Adult; Antifungal Agents; Contraindications; Humans; Immunocompromised Host; Male; Mycetoma; Mycoses; Scedosporium; Triazoles | 2015 |
Cost-benefit Analysis of Posaconazole Versus Fluconazole or Itraconazole as a Primary Antifungal Prophylaxis in High-risk Hematologic Patients: A Propensity Score-matched Analysis.
Topics: Adult; Antibiotic Prophylaxis; Antifungal Agents; Antineoplastic Agents; Cost Savings; Cost-Benefit Analysis; Drug Costs; Female; Fluconazole; Hospital Costs; Humans; Itraconazole; Leukemia, Myeloid, Acute; Male; Middle Aged; Mycoses; Primary Prevention; Propensity Score; Remission Induction; Republic of Korea; Retrospective Studies; Triazoles | 2015 |
Electrochemical behavior of the antifungal agents itraconazole, posaconazole and ketoconazole at a glassy carbon electrode.
Topics: Antifungal Agents; Carbon; Electrochemical Techniques; Electrochemistry; Electrodes; Indicators and Reagents; Itraconazole; Ketoconazole; Solutions; Triazoles | 2015 |
Posaconazole for primary antifungal prophylaxis in patients with acute myeloid leukaemia or myelodysplastic syndrome during remission induction chemotherapy: a single-centre retrospective study in Korea and clinical considerations.
Topics: Adult; Antifungal Agents; Female; Fluconazole; Humans; Incidence; Induction Chemotherapy; Leukemia, Myeloid, Acute; Male; Middle Aged; Mycoses; Myelodysplastic Syndromes; Remission Induction; Republic of Korea; Retrospective Studies; Time Factors; Triazoles | 2015 |
Potent In Vitro Antiproliferative Synergism of Combinations of Ergosterol Biosynthesis Inhibitors against Leishmania amazonensis.
Topics: 14-alpha Demethylase Inhibitors; Animals; Culture Media; Drug Synergism; Drug Therapy, Combination; Ergosterol; Farnesyl-Diphosphate Farnesyltransferase; Humans; Itraconazole; Leishmania mexicana; Leishmaniasis, Diffuse Cutaneous; Lipid Droplets; Membrane Potential, Mitochondrial; Mice; Mitochondria; Parasitic Sensitivity Tests; Pyridines; Quinuclidines; Reactive Oxygen Species; Sterol 14-Demethylase; Triazoles; Trypanocidal Agents | 2015 |
Antitrypanosomal Treatment with Benznidazole Is Superior to Posaconazole Regimens in Mouse Models of Chagas Disease.
Topics: 14-alpha Demethylase Inhibitors; Administration, Oral; Animals; Chagas Disease; Clinical Trials, Phase II as Topic; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Heart; Humans; Immunosuppression Therapy; Mice; NIH 3T3 Cells; Nitroimidazoles; Parasitemia; Recurrence; Sterol 14-Demethylase; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
In Vitro Activities of Eight Antifungal Drugs against a Global Collection of Genotyped Exserohilum Isolates.
Topics: Amphotericin B; Amplified Fragment Length Polymorphism Analysis; Antifungal Agents; Ascomycota; Caspofungin; Echinocandins; Fluconazole; Genotype; Itraconazole; Lipopeptides; Micafungin; Microbial Sensitivity Tests; Molecular Sequence Data; Nitriles; Pyridines; Triazoles; Voriconazole | 2015 |
Evaluation of Sulfobutylether-β-Cyclodextrin Exposure in a Critically Ill Patient Receiving Intravenous Posaconazole While Undergoing Continuous Venovenous Hemofiltration.
Topics: Administration, Intravenous; Adult; beta-Cyclodextrins; Critical Illness; Cyclodextrins; Female; Hemofiltration; Humans; Triazoles | 2015 |
In vivo efficacy of voriconazole and posaconazole therapy in a novel invertebrate model of Aspergillus fumigatus infection.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Disease Models, Animal; Larva; Lepidoptera; Microbial Sensitivity Tests; Survival Analysis; Triazoles; Voriconazole | 2015 |
Posaconazole vs fluconazole or itraconazole for prevention of invasive fungal diseases in patients with acute myeloid leukemia or myelodysplastic syndrome: a cost-effectiveness analysis in an Asian teaching hospital.
Topics: Antifungal Agents; Cost-Benefit Analysis; Decision Support Techniques; Fluconazole; Hong Kong; Hospitals, Teaching; Humans; Itraconazole; Leukemia, Myeloid, Acute; Models, Econometric; Mycoses; Myelodysplastic Syndromes; Socioeconomic Factors; Triazoles | 2016 |
In Vitro Susceptibility Profiles of Eight Antifungal Drugs against Clinical and Environmental Strains of Phaeoacremonium.
Topics: Amphotericin B; Anidulafungin; Antifungal Agents; Ascomycota; Caspofungin; Echinocandins; Fluconazole; Humans; Itraconazole; Lipopeptides; Microbial Sensitivity Tests; Mycoses; Nitriles; Pyridines; Triazoles; Voriconazole | 2015 |
Contribution of a Simple Bioassay in Effective Therapeutic Drug Monitoring of Posaconazole and Voriconazole.
Topics: Antifungal Agents; Biological Assay; Blood Proteins; Calibration; Drug Monitoring; Humans; Protein Binding; Triazoles; Voriconazole | 2015 |
Azole resistance in canine and feline isolates of Aspergillus fumigatus.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Cat Diseases; Cats; Cytochrome P-450 Enzyme System; Dog Diseases; Dogs; Drug Resistance, Fungal; Fungal Proteins; Itraconazole; Microbial Sensitivity Tests; Mutation; Triazoles; Voriconazole | 2015 |
Efficacy of Posaconazole in a Murine Model of Systemic Infection by Saprochaete capitata.
Topics: Animals; Antifungal Agents; Basidiomycota; beta-Glucans; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Immunocompromised Host; Kidney; Male; Mice, Inbred Strains; Microbial Sensitivity Tests; Mycoses; Neutropenia; Proteoglycans; Triazoles | 2015 |
Effect of Preexposure to Triazoles on Susceptibility and Virulence of Rhizopus oryzae.
Topics: Agar; Animals; Antifungal Agents; Culture Media; Disease Models, Animal; Drosophila melanogaster; Female; Fluconazole; Itraconazole; Microbial Sensitivity Tests; Mucormycosis; Rhizopus; Survival Analysis; Triazoles; Virulence; Voriconazole | 2015 |
Comparison of the EUCAST and CLSI Broth Microdilution Methods for Testing Isavuconazole, Posaconazole, and Amphotericin B against Molecularly Identified Mucorales Species.
Topics: Amphotericin B; Antifungal Agents; Humans; Microbial Sensitivity Tests; Mucorales; Mucormycosis; Nitriles; Pyridines; Species Specificity; Triazoles; Voriconazole | 2015 |
Voriconazole and posaconazole therapy for experimental Candida lusitaniae infection.
Topics: Animals; Antifungal Agents; beta-Glucans; Candida; Candidiasis; Colony Count, Microbial; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Kidney; Male; Mice; Proteoglycans; Treatment Outcome; Triazoles; Voriconazole | 2016 |
Activity of Isavuconazole and Other Azoles against Candida Clinical Isolates and Yeast Model Systems with Known Azole Resistance Mechanisms.
Topics: Alleles; Antifungal Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Candida albicans; Candida glabrata; Candidiasis; Cytochrome P-450 Enzyme System; Drug Resistance, Fungal; Fluconazole; Fungal Proteins; Gene Expression Regulation, Fungal; Humans; Itraconazole; Membrane Transport Proteins; Microbial Sensitivity Tests; Mutation; Nitriles; Protein Isoforms; Pyridines; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Triazoles; Voriconazole | 2016 |
Posaconazole plasma concentration in pediatric patients receiving antifungal prophylaxis after allogeneic hematopoietic stem cell transplantation.
Topics: Adolescent; Antifungal Agents; Chemoprevention; Child; Child, Preschool; Diet; Female; Hematopoietic Stem Cell Transplantation; Humans; Male; Mycoses; Plasma; Transplantation, Homologous; Triazoles | 2016 |
In Vivo Synergy of Amphotericin B plus Posaconazole in Murine Aspergillosis.
Topics: Amphotericin B; Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Drug Administration Schedule; Drug Resistance, Fungal; Drug Synergism; Gene Expression; Isoenzymes; Kidney; Lung; Male; Mice; Microbial Sensitivity Tests; Sterol 14-Demethylase; Survival Analysis; Triazoles | 2016 |
Aspergillus Mediastinitis after Orthotopic Heart Transplantation: A Case Report.
Topics: Amphotericin B; Antifungal Agents; Aspergillosis; Aspergillus; Combined Modality Therapy; Debridement; Drainage; Drug Administration Schedule; Drug Therapy, Combination; Female; Heart Transplantation; Humans; Mediastinitis; Middle Aged; Reoperation; Surgical Flaps; Surgical Wound Infection; Time Factors; Treatment Outcome; Triazoles; Voriconazole | 2015 |
Quantitative Analysis of Single-Nucleotide Polymorphism for Rapid Detection of TR34/L98H- and TR46/Y121F/T289A-Positive Aspergillus fumigatus Isolates Obtained from Patients in Iran from 2010 to 2014.
Topics: Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Cytochrome P-450 Enzyme System; DNA, Fungal; Drug Resistance, Fungal; Fungal Proteins; Gene Expression; Humans; Iran; Itraconazole; Microbial Sensitivity Tests; Microsatellite Repeats; Mycological Typing Techniques; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Retrospective Studies; Sequence Analysis, DNA; Triazoles; Voriconazole | 2016 |
Pharmacokinetics of Posaconazole Oral Suspension in Children Dosed According to Body Surface Area.
Topics: Administration, Oral; Adolescent; Antifungal Agents; Body Surface Area; Child; Child, Preschool; Chromatography, High Pressure Liquid; Female; Hematologic Neoplasms; Humans; Male; Mycoses; Plasma; Prospective Studies; Suspensions; Triazoles | 2016 |
In Vitro Activity of ASP2397 against Aspergillus Isolates with or without Acquired Azole Resistance Mechanisms.
Topics: Amino Acid Substitution; Amphotericin B; Antifungal Agents; Aspergillosis; Aspergillus; Aspergillus fumigatus; Azoles; Coordination Complexes; Cytochrome P-450 Enzyme System; Drug Resistance, Fungal; Fungal Proteins; Gene Expression; Humans; Itraconazole; Microbial Sensitivity Tests; Mutation; Peptides, Cyclic; Triazoles; Voriconazole | 2016 |
Azole Resistance in Aspergillus fumigatus Clinical Isolates from an Italian Culture Collection.
Topics: Amino Acid Substitution; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Bacterial Typing Techniques; Cytochrome P-450 Enzyme System; Drug Resistance, Fungal; Epidemiological Monitoring; Fungal Proteins; Gene Expression; Genotype; Humans; Italy; Itraconazole; Microbial Sensitivity Tests; Microsatellite Repeats; Mutation; Promoter Regions, Genetic; Triazoles; Voriconazole | 2016 |
Subtherapeutic Posaconazole Exposure and Treatment Outcome in Patients With Invasive Fungal Disease.
Topics: Adult; Antifungal Agents; Drug Administration Schedule; Drug Monitoring; Female; Humans; Linear Models; Male; Middle Aged; Multivariate Analysis; Mycoses; Retrospective Studies; Risk Factors; Treatment Outcome; Triazoles | 2015 |
Molecular Characterization of a Voriconazole-Resistant, Posaconazole-Susceptible Aspergillus fumigatus Isolate in a Lung Transplant Recipient in the United States.
Topics: Aged; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Cytochrome P-450 Enzyme System; Cytomegalovirus Infections; Drug Resistance, Fungal; Fungal Proteins; Humans; Lung Transplantation; Male; Microbial Sensitivity Tests; Transplant Recipients; Triazoles; United States; Voriconazole | 2016 |
An in vitro biorelevant gastrointestinal transfer (BioGIT) system for forecasting concentrations in the fasted upper small intestine: Design, implementation, and evaluation.
Topics: Dipyridamole; Fasting; Gastric Mucosa; Gastrointestinal Tract; In Vitro Techniques; Intestine, Small; Ketoconazole; Models, Biological; Ranitidine; Triazoles | 2016 |
A combination approach to treating fungal infections.
Topics: Antifungal Agents; Candida albicans; Cell Line, Tumor; Cell Survival; Drug Resistance, Fungal; Drug Synergism; Drug Therapy, Combination; Epithelial Cells; Fluconazole; Humans; Itraconazole; Microbial Sensitivity Tests; Species Specificity; Tobramycin; Triazoles; Voriconazole | 2015 |
A pharmacokinetic analysis of posaconazole oral suspension in the serum and alveolar compartment of lung transplant recipients.
Topics: Adult; Aged; Antifungal Agents; Bronchoalveolar Lavage Fluid; Chemoprevention; Female; Humans; Lung Transplantation; Male; Mass Spectrometry; Middle Aged; Prospective Studies; Serum; Suspensions; Transplant Recipients; Triazoles; Young Adult | 2016 |
Time-Kill Kinetics and In Vitro Antifungal Susceptibility of Non-fumigatus Aspergillus Species Isolated from Patients with Ocular Mycoses.
Topics: Amphotericin B; Anidulafungin; Antifungal Agents; Aspergillosis; Aspergillus; Caspofungin; Echinocandins; Eye; Eye Infections, Fungal; Humans; Itraconazole; Lipopeptides; Microbial Sensitivity Tests; Triazoles; Voriconazole | 2016 |
In Vitro Activities of Five Antifungal Drugs Against Opportunistic Agents of Aspergillus Nigri Complex.
Topics: Amphotericin B; Antifungal Agents; Aspergillosis; Aspergillus; Caspofungin; Echinocandins; Humans; Itraconazole; Lipopeptides; Microbial Sensitivity Tests; Triazoles; Voriconazole | 2016 |
Visual Hallucinations Associated with High Posaconazole Concentrations in Serum.
Topics: Aged; Antifungal Agents; Female; Hallucinations; Humans; Pulmonary Aspergillosis; Treatment Outcome; Triazoles | 2016 |
Quantification of the Triazole Antifungal Compounds Voriconazole and Posaconazole in Human Serum or Plasma Using Liquid Chromatography Electrospray Tandem Mass Spectrometry (HPLC-ESI-MS/MS).
Topics: Antifungal Agents; Chromatography, High Pressure Liquid; Drug Monitoring; Humans; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Triazoles; Voriconazole | 2016 |
Disseminated fusariosis by Fusarium proliferatum in a patient with aplastic anaemia receiving primary posaconazole prophylaxis - case report and review of the literature.
Topics: Anemia, Aplastic; Antifungal Agents; Aspergillosis; Aspergillus flavus; Coinfection; Fatal Outcome; Fusariosis; Fusarium; Humans; Immunocompromised Host; Male; Opportunistic Infections; Triazoles; Young Adult | 2016 |
Primary cutaneous mucormycosis developing after incision and drainage of a subcutaneous abscess in an immunocompetent host.
Topics: Abscess; Adult; Amphotericin B; Antifungal Agents; Drainage; Humans; Immunocompetence; Leg; Male; Methicillin-Resistant Staphylococcus aureus; Mucormycosis; Postoperative Complications; Skin Diseases; Staphylococcal Infections; Triazoles | 2016 |
Comparison of posaconazole serum concentrations from haematological cancer patients on posaconazole tablet and oral suspension for treatment and prevention of invasive fungal infections.
Topics: Adult; Aged; Antifungal Agents; Chemoprevention; Female; Humans; Invasive Fungal Infections; Male; Middle Aged; Neoplasms; Retrospective Studies; Serum; Suspensions; Tablets; Triazoles; Young Adult | 2016 |
Posaconazole in lung transplant recipients: use, tolerability, and efficacy.
Topics: Administration, Oral; Adult; Antifungal Agents; Drug Interactions; Female; Humans; Immunocompromised Host; Immunosuppressive Agents; Lung Transplantation; Male; Middle Aged; Mycoses; Tacrolimus; Triazoles; Young Adult | 2016 |
Virulence and Resistance to Antifungal Therapies of Scopulariopsis Species.
Topics: Amphotericin B; Animals; Antifungal Agents; Cyclophosphamide; Disease Models, Animal; Drug Resistance, Fungal; Humans; Immunocompromised Host; Male; Mice; Mycoses; Neutropenia; Scopulariopsis; Species Specificity; Survival Analysis; Triazoles; Virulence; Voriconazole | 2016 |
Galactomannan enzyme immunoassay and quantitative Real Time PCR as tools to evaluate the exposure and response in a rat model of aspergillosis after posaconazole prophylaxis.
Topics: Animals; Antifungal Agents; Biomarkers; Galactose; Immunoenzyme Techniques; Mannans; Pulmonary Aspergillosis; Rats; Real-Time Polymerase Chain Reaction; Triazoles | 2016 |
Posaconazole, a Second-Generation Triazole Antifungal Drug, Inhibits the Hedgehog Signaling Pathway and Progression of Basal Cell Carcinoma.
Topics: Animals; Antifungal Agents; Antineoplastic Agents; Carcinoma, Basal Cell; Cell Line, Tumor; Disease Models, Animal; Gene Knockout Techniques; Hedgehog Proteins; Humans; Mice; Signal Transduction; Skin Neoplasms; Smoothened Receptor; Triazoles; Xenograft Model Antitumor Assays | 2016 |
Laryngotracheal mucormycosis: Report of a case.
Topics: Antifungal Agents; Burkitt Lymphoma; Debridement; Dysphonia; Echinocandins; Hepatitis C, Chronic; HIV Infections; Humans; Hyperbaric Oxygenation; Laryngitis; Laryngoscopy; Lipopeptides; Male; Micafungin; Middle Aged; Mucormycosis; Neurosyphilis; Respiratory Distress Syndrome; Respiratory Sounds; Tracheitis; Tracheotomy; Triazoles | 2016 |
Susceptibility profile and epidemiological cut-off values of Cryptococcus neoformans species complex from Argentina.
Topics: AIDS-Related Opportunistic Infections; Amphotericin B; Antifungal Agents; Argentina; Cryptococcosis; Cryptococcus neoformans; Drug Resistance, Fungal; Epidemiologic Methods; Fluconazole; Flucytosine; HIV Infections; Humans; Itraconazole; Meningitis, Cryptococcal; Microbial Sensitivity Tests; Triazoles; Voriconazole | 2016 |
Posaconazole oral suspension primary prophylaxis in acute leukemia and allogeneic stem cell transplant patients: can it be used without measurement of plasma concentration?
Topics: Administration, Oral; Adolescent; Adult; Aged; Antifungal Agents; Child; Child, Preschool; Female; Humans; Immunocompromised Host; Leukemia; Male; Middle Aged; Mycoses; Plasma; Prospective Studies; Stem Cell Transplantation; Transplantation, Homologous; Triazoles; Young Adult | 2016 |
Characterization and In Vitro Evaluation of the Complexes of Posaconazole with β- and 2,6-di-O-methyl-β-cyclodextrin.
Topics: Antifungal Agents; beta-Cyclodextrins; Calorimetry, Differential Scanning; Solubility; Spectroscopy, Fourier Transform Infrared; Triazoles; Water | 2017 |
Posaconazole/hydroxypropyl-β-cyclodextrin host-guest system: Improving dissolution while maintaining antifungal activity.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Antifungal Agents; beta-Cyclodextrins; Drug Carriers; Fungi; Humans; Models, Molecular; Mycoses; Solubility; Triazoles; Water | 2016 |
Differences in Food Effects for 2 Weak Bases With Similar BCS Drug-Related Properties: What Is Happening in the Intestinal Lumen?
Topics: Adolescent; Adult; Biopharmaceutics; Cell Membrane; Computer Simulation; Fasting; Female; Food-Drug Interactions; Gastric Emptying; Humans; Intestinal Absorption; Intestinal Mucosa; Ketoconazole; Male; Middle Aged; Triazoles; Young Adult | 2016 |
In vitro activities of five antifungal agents against 199 clinical and environmental isolates of Aspergillus flavus, an opportunistic fungal pathogen.
Topics: Amphotericin B; Antifungal Agents; Aspergillosis; Aspergillus flavus; Caspofungin; Dose-Response Relationship, Drug; Drug Resistance, Fungal; Echinocandins; Environmental Microbiology; Humans; Iran; Itraconazole; Lipopeptides; Microbial Sensitivity Tests; Opportunistic Infections; Triazoles; Voriconazole | 2016 |
In Vitro Interactions between Target of Rapamycin Kinase Inhibitor and Antifungal Agents against Aspergillus Species.
Topics: Amphotericin B; Antifungal Agents; Aspergillus flavus; Aspergillus fumigatus; Benzoxazoles; Caspofungin; Drug Combinations; Drug Synergism; Echinocandins; Fungal Proteins; Gene Expression; Itraconazole; Lipopeptides; Microbial Sensitivity Tests; Pyrimidines; TOR Serine-Threonine Kinases; Triazoles; Voriconazole | 2016 |
[NEW ANTIFUNGAL DRUGS FOR PREVENTION AND TREATMENT OF VISCERAL MYCOSES].
Topics: Antifungal Agents; Caspofungin; Drug Therapy; Echinocandins; Humans; Lipopeptides; Micafungin; Mycoses; Nitriles; Pyridines; Treatment Outcome; Triazoles; Voriconazole | 2015 |
Inhibitory Potential of Antifungal Drugs on ATP-Binding Cassette Transporters P-Glycoprotein, MRP1 to MRP5, BCRP, and BSEP.
Topics: Amphotericin B; Antifungal Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Echinocandins; Fluconazole; HEK293 Cells; Humans; Itraconazole; Lipopeptides; Micafungin; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Triazoles; Voriconazole | 2016 |
Drug-Drug Interaction Associated with Mold-Active Triazoles among Hospitalized Patients.
Topics: Antifungal Agents; Drug Interactions; Hospitalization; Humans; Itraconazole; Microbial Sensitivity Tests; Triazoles; Voriconazole | 2016 |
Posaconazole Substitution for Voriconazole-Associated Phototoxic Effects.
Topics: Aged; Antifungal Agents; Chronic Disease; Dermatitis, Phototoxic; Exophiala; Female; Follow-Up Studies; Humans; Meningitis, Fungal; Phaeohyphomycosis; Retreatment; Risk Assessment; Treatment Outcome; Triazoles; Voriconazole | 2016 |
Outcome of empirical or targeted antifungal therapy after antifungal prophylaxis in febrile neutropenia.
Topics: Aged; Antifungal Agents; Cohort Studies; Drug Delivery Systems; Empirical Research; Febrile Neutropenia; Female; Humans; Itraconazole; Male; Middle Aged; Post-Exposure Prophylaxis; Retrospective Studies; Survival Rate; Treatment Outcome; Triazoles | 2016 |
High Intracellular Concentrations of Posaconazole Do Not Impact on Functional Capacities of Human Polymorphonuclear Neutrophils and Monocyte-Derived Macrophages In Vitro.
Topics: Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Cell Movement; Cells, Cultured; Humans; Macrophages; Neutrophils; Reactive Oxygen Species; Spores, Fungal; Triazoles | 2016 |
Pharmacokinetics of Posaconazole Suspension in Lung Transplant Patients with and without Cystic Fibrosis.
Topics: Adult; Aged; Antifungal Agents; Cystic Fibrosis; Female; Humans; Invasive Fungal Infections; Lung Transplantation; Male; Middle Aged; Triazoles | 2016 |
Stability-indicating HPLC method development and structural elucidation of novel degradation products in posaconazole injection by LC-TOF/MS, LC-MS/MS and NMR.
Topics: Chromatography, High Pressure Liquid; Hydrogen-Ion Concentration; Limit of Detection; Magnetic Resonance Spectroscopy; Mass Spectrometry; Oxidation-Reduction; Triazoles | 2016 |
Posaconazole plasma exposure correlated to intestinal mucositis in allogeneic stem cell transplant patients.
Topics: Administration, Oral; Adult; Antifungal Agents; Citrulline; Female; Hematopoietic Stem Cell Transplantation; Humans; Intestinal Mucosa; Male; Middle Aged; Mucositis; Mycoses; Suspensions; Tablets; Triazoles | 2016 |
Coadministration of posaconazole and sirolimus in allogeneic hematopoietic stem cell transplant recipients.
Topics: Adolescent; Adult; Aged; Female; Follow-Up Studies; Hematopoietic Stem Cell Transplantation; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; Middle Aged; Multiple Myeloma; Remission Induction; Risk; Sirolimus; Transplantation Conditioning; Transplantation, Homologous; Treatment Outcome; Triazoles; Young Adult | 2016 |
Long QT Syndrome Leading to Multiple Cardiac Arrests After Posaconazole Administration in an Immune-Compromised Patient with Sepsis: An Unusual Case Report.
Topics: Adult; Antifungal Agents; Female; Heart Arrest; Humans; Immunocompromised Host; Long QT Syndrome; Sepsis; Surgical Wound Infection; Triazoles | 2016 |
Molecular characterisation and antifungal susceptibility of clinical Trichosporon isolates in India.
Topics: Amphotericin B; Antifungal Agents; Female; Fluconazole; Genotype; Humans; India; Itraconazole; Male; Microbial Sensitivity Tests; Mycological Typing Techniques; Phenotype; Sequence Analysis, DNA; Triazoles; Trichosporon; Trichosporonosis; Voriconazole | 2016 |
The effect of hyperlipidemia on the pharmacokinetics, hepatic and pulmonary uptake of posaconazole in rat.
Topics: Animals; Antifungal Agents; Hyperlipidemias; Liver; Lung; Poloxamer; Protein Binding; Rats, Sprague-Dawley; Tissue Distribution; Triazoles | 2016 |
Gastrointestinal and Systemic Monitoring of Posaconazole in Humans After Fasted and Fed State Administration of a Solid Dispersion.
Topics: Adult; Antifungal Agents; Body Fluids; Catheterization; Cross-Over Studies; Delayed-Action Preparations; Drug Compounding; Duodenum; Fasting; Female; Food-Drug Interactions; Gastric Mucosa; Gastrointestinal Tract; Healthy Volunteers; Humans; Intestinal Absorption; Jejunum; Male; Triazoles; Young Adult | 2016 |
Effectiveness of increasing the frequency of posaconazole syrup administration to achieve optimal plasma concentrations in patients with haematological malignancy.
Topics: Administration, Oral; Adult; Antifungal Agents; Chemoprevention; Chromatography, Liquid; Female; Hematologic Neoplasms; Humans; Male; Middle Aged; Mycoses; Plasma; Prospective Studies; Tandem Mass Spectrometry; Triazoles | 2016 |
Fungal infection of cystic fibrosis patients - single center experience.
Topics: Amphotericin B; Antifungal Agents; Aspergillosis, Allergic Bronchopulmonary; Aspergillus fumigatus; Candida albicans; Candida tropicalis; Cystic Fibrosis; Drug Resistance, Multiple, Fungal; Fungi; Humans; Itraconazole; Microbial Sensitivity Tests; Mycoses; Scedosporium; Triazoles; Voriconazole; Yeasts | 2016 |
Identification and antifungal susceptibility of Candida species isolated from bloodstream infections in Konya, Turkey.
Topics: Amphotericin B; Anidulafungin; Antifungal Agents; Candida; Candida albicans; Candidiasis; Caspofungin; Echinocandins; Fluconazole; Humans; Lipopeptides; Microbial Sensitivity Tests; Species Specificity; Triazoles; Voriconazole | 2016 |
Susceptibility to antifungal agents and enzymatic activity of Candida haemulonii and Cutaneotrichosporon dermatis isolated from soft corals on the Brazilian reefs.
Topics: Animals; Anthozoa; Antifungal Agents; Basidiomycota; Brazil; Candida; DNA, Ribosomal; Drug Resistance, Multiple, Fungal; Esterases; Fluconazole; Gelatinases; Humans; Imidazoles; Microbial Sensitivity Tests; Naphthalenes; Sequence Analysis, DNA; Terbinafine; Triazoles | 2016 |
Management and treatment of Magnusiomyces capitatus (Geotrichum capitatum) pleural infection in a non-neutropenic patient with posaconazole. A new therapeutic opportunity?
Topics: Aged; Antifungal Agents; Female; Geotrichosis; Geotrichum; Humans; Triazoles | 2016 |
A cohort study on breakthrough invasive fungal infections in high-risk patients receiving antifungal prophylaxis.
Topics: Adolescent; Adult; Aged; Antifungal Agents; Chemoprevention; Cohort Studies; Echinocandins; Female; Hematologic Diseases; Humans; Incidence; Invasive Fungal Infections; Itraconazole; Lipopeptides; Male; Micafungin; Middle Aged; Triazoles; Young Adult | 2016 |
Posaconazole Plasma Concentrations on Days Three to Five Predict Steady-State Levels.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antifungal Agents; Area Under Curve; Drug Monitoring; Female; Hematologic Neoplasms; Humans; Male; Middle Aged; Mycoses; ROC Curve; Triazoles | 2016 |
Identification of Ebsulfur Analogues with Broad-Spectrum Antifungal Activity.
Topics: Amphotericin B; Animals; Antifungal Agents; Aspergillus; Candida; Fluconazole; HEK293 Cells; Hemolysis; Heterocyclic Compounds, 2-Ring; Humans; Itraconazole; Mice; Microbial Sensitivity Tests; Reactive Oxygen Species; Structure-Activity Relationship; Thiazoles; Triazoles; Voriconazole | 2016 |
Sodium Lauryl Sulfate Competitively Interacts with HPMC-AS and Consequently Reduces Oral Bioavailability of Posaconazole/HPMC-AS Amorphous Solid Dispersion.
Topics: Drug Liberation; Hypromellose Derivatives; Magnetic Resonance Spectroscopy; Pharmaceutical Solutions; Sodium Dodecyl Sulfate; Solubility; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Triazoles | 2016 |
Utilization of posaconazole oral suspension or delayed-released tablet salvage treatment for invasive fungal infection.
Topics: Administration, Oral; Adult; Aged; Alternaria; Antifungal Agents; Aspergillus; Delayed-Action Preparations; Fatal Outcome; Female; Humans; Invasive Fungal Infections; Male; Middle Aged; Mucormycosis; Retrospective Studies; Salvage Therapy; Suspensions; Tablets; Treatment Outcome; Triazoles | 2016 |
Recurrent trichosporonosis with central nervous system involvement in an allogeneic hematopoietic stem cell transplant recipient.
Topics: Anemia, Aplastic; Antibiotic Prophylaxis; Antifungal Agents; Caspofungin; Central Nervous System; Echinocandins; Female; Hematopoietic Stem Cell Transplantation; Humans; Hydrocephalus; Immunocompromised Host; Immunosuppression Therapy; Laminectomy; Lipopeptides; Magnetic Resonance Imaging; Opportunistic Infections; Recurrence; Transplantation, Autologous; Treatment Outcome; Triazoles; Trichosporon; Trichosporonosis; Ventriculoperitoneal Shunt; Voriconazole | 2016 |
Posaconazole: an emerging therapeutic option for invasive rhino-orbito-cerebral mucormycosis.
Topics: Adult; Antifungal Agents; Brain Diseases; Female; Humans; Male; Middle Aged; Mucorales; Mucormycosis; Nose Diseases; Orbital Diseases; Retrospective Studies; Triazoles; Young Adult | 2016 |
Successful Nonsurgical Eradication of Invasive Gastric Mucormycosis.
Topics: Aged; Amphotericin B; Antifungal Agents; Drug Therapy, Combination; Gastrointestinal Diseases; Humans; Male; Mucormycosis; Treatment Outcome; Triazoles | 2016 |
Safety, clinical effectiveness and trough plasma concentrations of intravenous posaconazole in patients with haematological malignancies and/or undergoing allogeneic haematopoietic stem cell transplantation: off-trial experience.
Topics: Administration, Intravenous; Adult; Antifungal Agents; Australia; Chemoprevention; Drug-Related Side Effects and Adverse Reactions; Female; Hematologic Neoplasms; Hematopoietic Stem Cell Transplantation; Humans; Male; Middle Aged; Mycoses; Plasma; Retrospective Studies; Transplantation, Homologous; Treatment Outcome; Triazoles | 2016 |
Severe palmar-plantar erythrodysesthesia and aplasia in an adult undergoing re-induction treatment with high-dose cytarabine for acute myelogenous leukemia: a possible drug interaction between posaconazole and cytarabine.
Topics: Cytarabine; Drug Interactions; Erythema; Female; Hand-Foot Syndrome; Humans; Leukemia, Myeloid, Acute; Triazoles; Young Adult | 2017 |
Increased inhibition of cytochrome P450 3A4 with the tablet formulation of posaconazole.
Topics: Administration, Oral; Adult; Antifungal Agents; Biological Availability; Chemistry, Pharmaceutical; Cytochrome P-450 CYP3A; Humans; Suspensions; Tablets; Triazoles; Young Adult | 2016 |
Posaconazole Therapeutic Drug Monitoring in a Regional Hospital Setting.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antifungal Agents; Australia; Drug Monitoring; Female; Hospitals; Humans; Male; Middle Aged; Mycoses; Retrospective Studies; Serum; Triazoles; Young Adult | 2016 |
Economic evaluation of azoles as primary prophylaxis for the prevention of invasive fungal infections in Spanish patients undergoing allogeneic haematopoietic stem cell transplant.
Topics: Adult; Antifungal Agents; Cost-Benefit Analysis; Decision Support Techniques; Fluconazole; Hematopoietic Stem Cell Transplantation; Humans; Invasive Fungal Infections; Itraconazole; Spain; Triazoles; Voriconazole | 2017 |
Aspergillus fumigatus carrying TR34/L98H resistance allele causing complicated suppurative otitis media in Tanzania: Call for improved diagnosis of fungi in sub-Saharan Africa.
Topics: Adolescent; Adult; Alleles; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Drug Resistance, Fungal; Female; Genes, Fungal; Humans; Itraconazole; Microbial Sensitivity Tests; Otitis Media, Suppurative; Tanzania; Triazoles; Voriconazole; Young Adult | 2016 |
Long-Lasting Protective Effect of Posaconazole Prophylaxis in Patients with Acute Myeloid Leukemia Receiving Allogeneic Hematopoietic Stem Cell Transplantation.
Topics: Adolescent; Adult; Aged; Allografts; Antifungal Agents; Blood Donors; Female; Fluconazole; Hematopoietic Stem Cell Transplantation; Humans; Induction Chemotherapy; Invasive Fungal Infections; Itraconazole; Leukemia, Myeloid, Acute; Male; Middle Aged; Premedication; Salvage Therapy; Survival Analysis; Triazoles; Young Adult | 2016 |
Antimold Prophylaxis May Reduce the Risk of Invasive Fusariosis in Hematologic Patients with Superficial Skin Lesions with Positive Culture for Fusarium.
Topics: Adolescent; Adult; Aged; Anemia, Aplastic; Antifungal Agents; Female; Fusariosis; Fusarium; Hematopoietic Stem Cell Transplantation; Humans; Immunocompromised Host; Intertrigo; Leukemia; Male; Middle Aged; Onychomycosis; Prospective Studies; Skin; Triazoles; Voriconazole; Young Adult | 2016 |
Posaconazole plasma concentrations in pediatric patients receiving antifungal prophylaxis during neutropenia.
Topics: Adolescent; Age Factors; Antifungal Agents; Chemoprevention; Child; Child, Preschool; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Infant; Infant, Newborn; Male; Mycoses; Neutropenia; Plasma; Retrospective Studies; Sex Factors; Triazoles | 2017 |
In vitro evaluation of the impact of gastrointestinal transfer on luminal performance of commercially available products of posaconazole and itraconazole using BioGIT.
Topics: Capsules; Duodenum; Fasting; Gastric Mucosa; Gastrointestinal Transit; Humans; Intestinal Absorption; Itraconazole; Phenobarbital; Solubility; Triazoles | 2016 |
Synergistic effect of anidulafungin combined with posaconazole in experimental aspergillosis.
Topics: Anidulafungin; Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Echinocandins; Kidney; Male; Mice; Survival Analysis; Triazoles | 2017 |
Genotyping of Aspergillus fumigatus Reveals Compartmentalization of Genotypes in Disseminated Disease after Invasive Pulmonary Aspergillosis.
Topics: Adrenal Cortex Hormones; Adult; Antifungal Agents; Aspergillus fumigatus; Female; Genotype; Graft vs Host Disease; Humans; Invasive Pulmonary Aspergillosis; Itraconazole; Lung; Male; Microbial Sensitivity Tests; Microsatellite Repeats; Molecular Typing; Mycological Typing Techniques; Triazoles; Voriconazole | 2017 |
Comparative Evaluation of Etest, EUCAST, and CLSI Methods for Amphotericin B, Voriconazole, and Posaconazole against Clinically Relevant Fusarium Species.
Topics: Amphotericin B; Antifungal Agents; Fungal Proteins; Fusarium; Microbial Sensitivity Tests; Triazoles; Voriconazole | 2017 |
Serum galactomannan surveillance may be safely withdrawn from antifungal management of hematology patients on effective antimold prophylaxis: a pilot single-center study.
Topics: Adolescent; Adult; Aged; Antifungal Agents; Female; Fungi; Galactose; Hematologic Neoplasms; Hematopoietic Stem Cell Transplantation; Humans; Male; Mannans; Middle Aged; Mycoses; Prospective Studies; Triazoles | 2017 |
Posaconazole-Loaded Leukocytes as a Novel Treatment Strategy Targeting Invasive Pulmonary Aspergillosis.
Topics: Animals; Antifungal Agents; Chemotaxis; Female; HL-60 Cells; Humans; Invasive Pulmonary Aspergillosis; Lung; Mice; Mice, Inbred BALB C; Triazoles | 2017 |
An unusual case of Candida ciferrii fungemia in an immunocompromised patient with Crohn's and Mycobacterium bovis disease.
Topics: Adult; Antifungal Agents; Candida; Candidemia; Catheter-Related Infections; Catheterization, Central Venous; Crohn Disease; Female; Humans; Immunocompromised Host; Mycobacterium bovis; Treatment Outcome; Triazoles; Tuberculosis | 2016 |
Failure to achieve therapeutic levels with high-dose posaconazole tablets potentially due to enhanced clearance.
Topics: Antifungal Agents; Drug Monitoring; Humans; Leukemia, Myeloid, Acute; Male; Metabolic Clearance Rate; Middle Aged; Tablets; Triazoles | 2018 |
Successful Treatment of Rhino-Orbital-Cerebral Mucormycosis in a Child With Leukemia.
Topics: Amphotericin B; Antifungal Agents; Brain; Child, Preschool; Female; Humans; Hyperbaric Oxygenation; Mucormycosis; Naphthalenes; Nose; Opportunistic Infections; Orbit; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Terbinafine; Triazoles | 2017 |
Trypanosoma brucei CYP51: Essentiality and Targeting Therapy in an Experimental Model.
Topics: 14-alpha Demethylase Inhibitors; Animals; Anti-Bacterial Agents; Cytokinesis; Disease Models, Animal; Doxycycline; Eflornithine; Ergosterol; Humans; Mice; Nifurtimox; Phenotype; RNA Interference; Sterol 14-Demethylase; Triazoles; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2016 |
Acute reversible pancreatitis induced by posaconazole.
Topics: Acute Disease; Antifungal Agents; Female; Humans; Leukemia, Myeloid, Acute; Lipase; Mycoses; Pancreatitis; Triazoles | 2017 |
Skin lesion in a patient with acute myeloid leukemia.
Topics: Amphotericin B; Antibiotic Prophylaxis; Antifungal Agents; Biopsy; Debridement; Dermatomycoses; Febrile Neutropenia; Forearm; Humans; Immunocompromised Host; Induction Chemotherapy; Invasive Fungal Infections; Leukemia, Myeloid, Acute; Male; Middle Aged; Mucormycosis; Polymerase Chain Reaction; Rhizopus; RNA, Fungal; Triazoles | 2017 |
Assessment of Bioequivalence of Weak Base Formulations Under Various Dosing Conditions Using Physiologically Based Pharmacokinetic Simulations in Virtual Populations. Case Examples: Ketoconazole and Posaconazole.
Topics: Administration, Oral; Adult; Antifungal Agents; Carbonated Beverages; Computer Simulation; Fasting; Gastric Mucosa; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Intestine, Small; Ketoconazole; Models, Biological; Solubility; Therapeutic Equivalency; Triazoles | 2017 |
A rapid UPLC-MS/MS assay for the simultaneous measurement of fluconazole, voriconazole, posaconazole, itraconazole, and hydroxyitraconazole concentrations in serum.
Topics: Antifungal Agents; Blood Chemical Analysis; Chromatography, High Pressure Liquid; Fluconazole; Humans; Itraconazole; Limit of Detection; Reproducibility of Results; Tandem Mass Spectrometry; Time Factors; Triazoles; Voriconazole | 2017 |
Successful Posaconazole Therapy of Disseminated Alternariosis due to Alternaria infectoria in a Heart Transplant Recipient.
Topics: Alternaria; Antifungal Agents; Debridement; Dermatomycoses; DNA, Fungal; DNA, Ribosomal Spacer; Heart Transplantation; Histocytochemistry; Humans; Lung Diseases, Fungal; Male; Microscopy; Middle Aged; Phaeohyphomycosis; Sequence Analysis, DNA; Transplant Recipients; Treatment Outcome; Triazoles; Tubulin | 2017 |
Blood and tissue distribution of posaconazole in a rat model of invasive pulmonary aspergillosis.
Topics: Animals; Antifungal Agents; Disease Models, Animal; Female; Invasive Pulmonary Aspergillosis; Lung; Rats, Wistar; Serum; Tissue Distribution; Triazoles | 2017 |
Synergistic drug combination effectively blocks Ebola virus infection.
Topics: Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; Clarithromycin; Drug Combinations; Drug Synergism; Ebolavirus; Hemorrhagic Fever, Ebola; High-Throughput Screening Assays; Humans; Mefloquine; Sphingomyelin Phosphodiesterase; Toremifene; Triazoles; Vero Cells; Virus Internalization | 2017 |
Tintelnotia, a new genus in Phaeosphaeriaceae harbouring agents of cornea and nail infections in humans.
Topics: Amphotericin B; Antifungal Agents; Ascomycota; Caspofungin; Cornea; Echinocandins; Eye Infections, Fungal; Female; Humans; Itraconazole; Keratitis; Lipopeptides; Microbial Sensitivity Tests; Middle Aged; Nails; Naphthalenes; Phylogeny; Terbinafine; Triazoles; Voriconazole | 2017 |
Comparison of serum concentrations between different dosing strategies of posaconazole delayed-release tablet at a large academic medical centre.
Topics: Academic Medical Centers; Administration, Oral; Adult; Antifungal Agents; Delayed-Action Preparations; Drug Dosage Calculations; Drug Monitoring; Female; Humans; Invasive Fungal Infections; Male; Middle Aged; Retrospective Studies; Tablets; Triazoles | 2017 |
Givinostat exhibits in vitro synergy with posaconazole against Aspergillus spp.
Topics: Antifungal Agents; Aspergillus flavus; Aspergillus fumigatus; Carbamates; Drug Synergism; Microbial Sensitivity Tests; Triazoles | 2017 |
Therapeutic drug monitoring of posaconazole oral suspension in paediatric patients younger than 13 years of age: a retrospective analysis and literature review.
Topics: Administration, Oral; Antifungal Agents; Child; Child, Preschool; Drug Monitoring; Humans; Male; Mycoses; Retrospective Studies; Suspensions; Triazoles | 2017 |
Cerebral Rhizomucor Infection Treated by Posaconazole Delayed-Release Tablets in an Allogeneic Stem Cell Transplant Recipient.
Topics: Adult; Antifungal Agents; Delayed-Action Preparations; Fatal Outcome; Female; Humans; Immunocompromised Host; Leukemia, Myelomonocytic, Acute; Mucormycosis; Rhizomucor; Stem Cell Transplantation; Tablets; Transplantation, Homologous; Triazoles | 2017 |
Triazoles inhibit cholesterol export from lysosomes by binding to NPC1.
Topics: Androstenes; Animals; Antifungal Agents; Binding Sites; Biological Transport; Carrier Proteins; Cell Line; CHO Cells; Cholesterol; Cricetulus; Endocytosis; Itraconazole; Ketoconazole; Lysosomes; Membrane Glycoproteins; Protein Binding; Protein Domains; Triazoles | 2017 |
Preparation and evaluation of posaconazole-loaded enteric microparticles in rats.
Topics: Acetone; Animals; Chemistry, Pharmaceutical; Desiccation; Drug Compounding; Drug Liberation; Microspheres; Particle Size; Polymers; Rats; Rats, Wistar; Solubility; Solvents; Triazoles | 2017 |
In vitro drug susceptibility of two strains of the wildlife trypanosome, Trypanosoma copemani: A comparison with Trypanosoma cruzi.
Topics: Animals; Animals, Wild; Australia; Cell Line; Drug Discovery; High-Throughput Screening Assays; Inhibitory Concentration 50; Melarsoprol; Nitroimidazoles; Phosphorylcholine; Potoroidae; Pyrimidines; Triazoles; Trypanocidal Agents; Trypanosoma; Trypanosoma cruzi | 2017 |
[Clusters of Fusarium solani infection in juvenile captive born Caretta caretta sea turtles].
Topics: Animal Diseases; Animals; Animals, Zoo; Antifungal Agents; Conservation of Natural Resources; Endangered Species; Fusariosis; Fusarium; Tomography, X-Ray Computed; Triazoles; Turtles | 2017 |
Synergistic Effects of Tetrandrine with Posaconazole Against Aspergillus fumigatus.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Benzylisoquinolines; Candidiasis; Drug Resistance, Fungal; Drug Synergism; Female; Humans; Itraconazole; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Triazoles; Voriconazole | 2017 |
Mucormycosis pulmonary abscess, containment in a patient with uncontrolled diabetes mellitus.
Topics: Antifungal Agents; Diabetes Complications; Diabetes Mellitus; Humans; Lung Abscess; Lung Diseases, Fungal; Male; Middle Aged; Mucormycosis; Pneumonectomy; Radiography, Thoracic; Surgical Flaps; Tomography, X-Ray Computed; Triazoles | 2017 |
Inhibition of 11β-hydroxysteroid dehydrogenase 2 by the fungicides itraconazole and posaconazole.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Animals; Antifungal Agents; Enzyme Inhibitors; HEK293 Cells; Humans; Itraconazole; Rats; Structure-Activity Relationship; Triazoles | 2017 |
Comparison of two in vitro antifungal sensitivity tests and monitoring during therapy of Sporothrix schenckii sensu stricto in Malaysian cats.
Topics: Amphotericin B; Animals; Antifungal Agents; Cat Diseases; Cats; In Vitro Techniques; Itraconazole; Ketoconazole; Malaysia; Microbial Sensitivity Tests; Naphthalenes; Sporothrix; Sporotrichosis; Terbinafine; Triazoles | 2017 |
Use of Optical Imaging Technology in the Validation of a New, Rapid, Cost-Effective Drug Screen as Part of a Tiered
Topics: Amphotericin B; Animals; Antiprotozoal Agents; Cell Line; Cell Survival; Drug Evaluation, Preclinical; Female; Firefly Luciferin; Fluconazole; Genes, Reporter; High-Throughput Screening Assays; Leishmania major; Leishmaniasis, Cutaneous; Luciferases; Luminescent Measurements; Macrophages; Meglumine; Meglumine Antimoniate; Mesocricetus; Mice; Mice, Inbred BALB C; Ofloxacin; Optical Imaging; Organisms, Genetically Modified; Organometallic Compounds; Triazoles | 2017 |
Epidemiological investigation of Candida species causing bloodstream infection in paediatric small bowel transplant recipients.
Topics: Adolescent; Adult; Amphotericin B; Antifungal Agents; Candida; Candidemia; Caspofungin; DNA, Fungal; Drug Resistance, Fungal; Echinocandins; Female; Humans; Intestine, Small; Itraconazole; Lipopeptides; Male; Multilocus Sequence Typing; Sequence Analysis, DNA; Transplant Recipients; Triazoles; Young Adult | 2017 |
A case report of intravenous posaconazole in hepatic and renal impairment patient with invasive Aspergillus terreus infection: safety and role of therapeutic drug monitoring.
Topics: Administration, Intravenous; Adult; Antifungal Agents; Aspergillus; Drug Monitoring; Fatal Outcome; Humans; Invasive Pulmonary Aspergillosis; Kidney Diseases; Liver Diseases; Male; Triazoles | 2017 |
[Mucormycosis cutanea- clinical case presentation souvenir etiopatogenia diagnosis and treatment].
Topics: Aged; Amphotericin B; Antifungal Agents; Debridement; Fatal Outcome; Humans; Male; Mucormycosis; Risk Factors; Triazoles | 2016 |
Hypokalemia and Hypertension Associated with Supratherapeutic Posaconazole Levels.
Topics: Adult; Antifungal Agents; Histoplasmosis; Humans; Hypertension; Hypokalemia; Lymphoma, Large B-Cell, Diffuse; Male; Mycoses; Triazoles | 2017 |
Posaconazole Plasma Monitoring in Immunocompromised Children.
Topics: Child; Child, Preschool; Female; Hematopoietic Stem Cell Transplantation; Humans; Immunocompromised Host; Infant; Male; Retrospective Studies; Triazoles | 2017 |
The cost of treating mucormycosis with isavuconazole compared with standard therapy in the UK.
Topics: Amphotericin B; Antifungal Agents; Case-Control Studies; Drug Costs; Hospitalization; Humans; Invasive Fungal Infections; Models, Economic; Mucormycosis; Nitriles; Pyridines; Triazoles; United Kingdom | 2017 |
Diaporthe soft tissue infection in a heart transplant patient.
Topics: Aged; Antifungal Agents; Ascomycota; DNA, Fungal; Glycopeptides; Heart Transplantation; Humans; Immunosuppression Therapy; Male; Mycoses; Myocardial Ischemia; Polymerase Chain Reaction; Soft Tissue Infections; Thigh; Tomography, X-Ray Computed; Triazoles | 2017 |
Determinants of the Magnitude of Interaction Between Tacrolimus and Voriconazole/Posaconazole in Solid Organ Recipients.
Topics: Antifungal Agents; Biomarkers; Cytochrome P-450 CYP3A; Drug Interactions; Female; Follow-Up Studies; Genotype; Graft Rejection; Graft Survival; Humans; Immunosuppressive Agents; Male; Middle Aged; Organ Transplantation; Polymorphism, Single Nucleotide; Postoperative Complications; Prognosis; Retrospective Studies; Risk Factors; Tacrolimus; Triazoles; Voriconazole | 2017 |
A New Epoch in Antitrypanosomal Treatment for Chagas Disease.
Topics: Animals; Chagas Disease; Nitroimidazoles; Parasites; Triazoles | 2017 |
Prophylaxis with Isavuconazole or Posaconazole Protects Immunosuppressed Mice from Pulmonary Mucormycosis.
Topics: Animals; Antibiotic Prophylaxis; Antifungal Agents; Disease Models, Animal; Immunosuppression Therapy; Lung Diseases, Fungal; Mice; Mucormycosis; Nitriles; Pyridines; Rhizopus; Triazoles; Voriconazole | 2017 |
Comparing Azole Plasma Trough Levels in Lung Transplant Recipients: Percentage of Therapeutic Levels and Intrapatient Variability.
Topics: Antifungal Agents; Azoles; Drug Monitoring; Female; Humans; Itraconazole; Lung Transplantation; Male; Middle Aged; Plasma; Retrospective Studies; Tablets; Transplant Recipients; Triazoles; Voriconazole | 2017 |
Cutaneous phaeohyphomycosis in a hematopoietic stem cell transplant patient caused by Alternaria rosae: First case report.
Topics: Acute Kidney Injury; Acyclovir; Aged; Alternaria; Alternariosis; Antibiotic Prophylaxis; Antifungal Agents; Drug Therapy, Combination; Fatal Outcome; Graft vs Host Disease; Hand; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppression Therapy; Levofloxacin; Magnetic Resonance Imaging; Male; Microbial Sensitivity Tests; Paranasal Sinuses; Phaeohyphomycosis; Pneumonia; Prednisone; Primary Myelofibrosis; Respiratory Insufficiency; Spores, Fungal; Transplantation, Homologous; Triazoles; Voriconazole | 2017 |
Hyperlipidemia Alters the Pharmacokinetics of Posaconazole and Vincristine Upon Co-Administration in Rats.
Topics: Animals; Drug Interactions; Drug Therapy, Combination; Hyperlipidemias; Rats; Rats, Sprague-Dawley; Tissue Distribution; Triazoles; Vincristine | 2017 |
Triazole Resistance in
Topics: Antifungal Agents; Aspergillus fumigatus; China; Drug Resistance, Fungal; Itraconazole; Microbial Sensitivity Tests; Promoter Regions, Genetic; Tandem Repeat Sequences; Triazoles; Voriconazole | 2017 |
Topics: Aged; Antifungal Agents; Aspergillosis; Brain; Female; Humans; Immunocompromised Host; Lung Diseases, Fungal; Triazoles; Voriconazole | 2017 |
Dihydroorotate dehydrogenase inhibitor F901318 has potent in vitro activity against Scedosporium species and Lomentospora prolificans.
Topics: Antifungal Agents; Ascomycota; Caspofungin; Dihydroorotate Dehydrogenase; Echinocandins; Humans; Lipopeptides; Microbial Sensitivity Tests; Mycoses; Oxidoreductases Acting on CH-CH Group Donors; Scedosporium; Triazoles; Voriconazole | 2017 |
Changing epidemiology of candidaemia in Australia.
Topics: Anidulafungin; Antifungal Agents; Australia; Azoles; Candida; Candida glabrata; Candida tropicalis; Candidemia; Caspofungin; Drug Resistance, Fungal; Echinocandins; Female; Fluconazole; Humans; Incidence; Lipopeptides; Male; Micafungin; Microbial Sensitivity Tests; Sequence Analysis, DNA; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Triazoles; Voriconazole | 2017 |
Clinical effectiveness of early posaconazole suspension pre-emptive therapy in lung transplant recipients: The Alfred's experience.
Topics: Adult; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Cohort Studies; Drug Monitoring; Female; Humans; Lung Transplantation; Male; Middle Aged; Retrospective Studies; Suspensions; Transplant Recipients; Treatment Outcome; Triazoles; Voriconazole | 2017 |
Changes in In Vitro Susceptibility Patterns of Aspergillus to Triazoles and Correlation With Aspergillosis Outcome in a Tertiary Care Cancer Center, 1999-2015.
Topics: Adult; Antifungal Agents; Aspergillosis; Aspergillus; Aspergillus fumigatus; Cohort Studies; Cytochrome P-450 Enzyme System; Drug Resistance, Fungal; Ergosterol; Female; Fungal Proteins; Hematologic Neoplasms; Hematopoietic Stem Cell Transplantation; Humans; Invasive Pulmonary Aspergillosis; Male; Microbial Sensitivity Tests; Polymorphism, Genetic; Prospective Studies; Tertiary Healthcare; Treatment Outcome; Triazoles; Voriconazole; Young Adult | 2017 |
Enhancement of dissolution rate through eutectic mixture and solid solution of posaconazole and benznidazole.
Topics: Drug Combinations; Drug Compounding; Nitroimidazoles; Solubility; Triazoles | 2017 |
Susceptibility Testing of Common and Uncommon Aspergillus Species against Posaconazole and Other Mold-Active Antifungal Azoles Using the Sensititre Method.
Topics: Antifungal Agents; Aspergillosis; Aspergillus; Drug Resistance, Fungal; Itraconazole; Microbial Sensitivity Tests; Sterol 14-Demethylase; Triazoles; Voriconazole | 2017 |
A multi-centric Study of Candida bloodstream infection in Lima-Callao, Peru: Species distribution, antifungal resistance and clinical outcomes.
Topics: Adolescent; Adult; Aged; Amphotericin B; Anidulafungin; Antifungal Agents; Candida; Candidemia; Child; Child, Preschool; Drug Resistance, Fungal; Echinocandins; Female; Fluconazole; Humans; Incidence; Infant; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Peru; Prospective Studies; Triazoles; Voriconazole; Young Adult | 2017 |
Mucormycosis in renal transplant recipients: review of 174 reported cases.
Topics: Adolescent; Adult; Aged; Amphotericin B; Antifungal Agents; Child; Debridement; Deoxycholic Acid; Diabetes Mellitus; Female; Humans; Immunocompromised Host; Kidney Transplantation; Male; Middle Aged; Mucormycosis; Rhizopus; Transplant Recipients; Triazoles; Young Adult | 2017 |
Unique case report of a chromomycosis and Listeria in soft tissue and cerebellar abscesses after kidney transplantation.
Topics: Adult; Amoxicillin; Ascomycota; Brain Abscess; Chromoblastomycosis; Humans; Kidney Transplantation; Listeria monocytogenes; Listeriosis; Male; Middle Aged; Soft Tissue Infections; Sporotrichosis; Triazoles | 2017 |
Minimal inhibitory concentration distributions and epidemiological cutoff values of five antifungal agents against Sporothrix brasiliensis.
Topics: Amphotericin B; Animals; Antifungal Agents; Cats; Drug Resistance, Fungal; Humans; Itraconazole; Ketoconazole; Microbial Sensitivity Tests; Naphthalenes; Sporothrix; Terbinafine; Triazoles | 2017 |
Rhinocerebral Mucormycosis: Report of a Rare Case.
Topics: Aged; Amphotericin B; Antifungal Agents; Humans; Male; Mucormycosis; Necrosis; Paranasal Sinuses; Tomography, X-Ray Computed; Triazoles | 2017 |
Multicentre study of posaconazole delayed-release tablet serum level and association with hepatotoxicity and QTc prolongation.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antifungal Agents; Arrhythmias, Cardiac; Chemical and Drug Induced Liver Injury; Delayed-Action Preparations; Electrocardiography; Female; Humans; Liver Function Tests; Male; Middle Aged; Retrospective Studies; Serum; Tablets; Triazoles; Young Adult | 2017 |
Treatment of refractory sino-nasal aspergillosis with posaconazole and terbinafine in 10 dogs.
Topics: Animals; Antifungal Agents; Aspergillosis; Dog Diseases; Dogs; Naphthalenes; Prospective Studies; Terbinafine; Treatment Outcome; Triazoles | 2017 |
Antifungal prophylaxis in newly diagnosed AML patients-Adherence to guidelines and feasibility in a real life setting.
Topics: Adult; Aged; Antifungal Agents; Female; Fluconazole; Galactose; Guideline Adherence; Guidelines as Topic; Humans; Leukemia, Myeloid, Acute; Male; Mannans; Middle Aged; Mycoses; Pre-Exposure Prophylaxis; Retrospective Studies; Triazoles | 2017 |
Topics: Antifungal Agents; Azoles; Candida tropicalis; Drug Resistance, Fungal; Fluconazole; Fungal Proteins; Humans; Microbial Sensitivity Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Triazoles | 2017 |
Real-Life Assessment of the Safety and Effectiveness of the New Tablet and Intravenous Formulations of Posaconazole in the Prophylaxis of Invasive Fungal Infections via Analysis of 343 Courses.
Topics: Administration, Intravenous; Administration, Oral; Algorithms; Antifungal Agents; Cohort Studies; Drug Compounding; Female; Hematologic Neoplasms; Humans; Invasive Fungal Infections; Leukemia, Myeloid, Acute; Male; Middle Aged; Pre-Exposure Prophylaxis; Retrospective Studies; Tablets; Tertiary Care Centers; Treatment Outcome; Triazoles | 2017 |
SEIFEM 2010-E: economic evaluation of posaconazole for antifungal prophylaxis in patients with acute myeloid leukemia receiving induction chemotherapy.
Topics: Adult; Aged; Aged, 80 and over; Antibiotic Prophylaxis; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Cost-Benefit Analysis; Drug Costs; Female; Humans; Induction Chemotherapy; Leukemia, Myeloid, Acute; Male; Middle Aged; Monte Carlo Method; Mycoses; Outcome Assessment, Health Care; Triazoles; Young Adult | 2017 |
Topics: 11-beta-Hydroxysteroid Dehydrogenases; Aged; Antifungal Agents; Cortisone; Humans; Hydrocortisone; Hypertension; Hypokalemia; Lung; Male; Mineralocorticoid Excess Syndrome, Apparent; Pulmonary Aspergillosis; Triazoles | 2017 |
Cost-effectiveness of posaconazole tablets versus fluconazole as prophylaxis for invasive fungal diseases in patients with graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.
Topics: Antifungal Agents; Cost-Benefit Analysis; Female; Fluconazole; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Male; Mycoses; Spain; Tablets; Triazoles | 2018 |
Topics: Aged, 80 and over; Amphotericin B; Antifungal Agents; Australia; Debridement; Humans; Leg Injuries; Male; Mucormycosis; Soft Tissue Infections; Treatment Outcome; Triazoles | 2017 |
Prophylactic Treatment with VT-1161 Protects Immunosuppressed Mice from Rhizopus arrhizus var. arrhizus Infection.
Topics: Animals; Antifungal Agents; Immunocompromised Host; Male; Mice; Microbial Sensitivity Tests; Mucormycosis; Protective Agents; Pyridines; Rhizopus; Tetrazoles; Triazoles | 2017 |
[Primary antifungal prophylaxis with posaconazole plays a pivotal role during chemotherapy of acute myeloid leukemia].
Topics: Antifungal Agents; Humans; Incidence; Induction Chemotherapy; Leukemia, Myeloid, Acute; Mycoses; Remission Induction; Retrospective Studies; Triazoles | 2017 |
Pharmacodynamics and Follow-Up Period in the Treatment of Human Trypanosoma Cruzi Infections With Posaconazole.
Topics: Animals; Chagas Disease; Follow-Up Studies; Humans; Nitroimidazoles; Parasites; Triazoles | 2017 |
Comparing the safety and efficacy of voriconazole versus posaconazole in the prevention of invasive fungal infections in high-risk patients with hematological malignancies.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antifungal Agents; Chemoprevention; Drug-Related Side Effects and Adverse Reactions; Female; Hematologic Neoplasms; Hospitals, University; Humans; Invasive Fungal Infections; Male; Middle Aged; Retrospective Studies; Survival Analysis; Texas; Treatment Outcome; Triazoles; Voriconazole; Young Adult | 2017 |
Invasive fungal infection following chemotherapy for acute myeloid leukaemia-Experience from a developing country.
Topics: Adolescent; Adult; Aged; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Developing Countries; Female; Humans; India; Induction Chemotherapy; Invasive Fungal Infections; Leukemia, Myeloid, Acute; Male; Middle Aged; Retrospective Studies; Salvage Therapy; Triazoles; Young Adult | 2017 |
Reliable and Easy-To-Use Liquid Chromatography-Tandem Mass Spectrometry Method for Simultaneous Analysis of Fluconazole, Isavuconazole, Itraconazole, Hydroxy-Itraconazole, Posaconazole, and Voriconazole in Human Plasma and Serum.
Topics: Acetonitriles; Adult; Antifungal Agents; Calibration; Chromatography, Liquid; Drug Monitoring; Female; Fluconazole; Humans; Indicators and Reagents; Isotope Labeling; Itraconazole; Nitriles; Plasma; Pyridines; Reproducibility of Results; Tandem Mass Spectrometry; Triazoles; Voriconazole | 2017 |
Progressive Dispersion of Azole Resistance in Aspergillus fumigatus: Fatal Invasive Aspergillosis in a Patient with Acute Myeloid Leukemia Infected with an A. fumigatus Strain with a
Topics: Aged; Alleles; Amphotericin B; Antifungal Agents; Aspergillus fumigatus; Azoles; Caspofungin; Cytochrome P-450 Enzyme System; Drug Resistance, Multiple, Fungal; Echinocandins; Fungal Proteins; Humans; Invasive Pulmonary Aspergillosis; Leukemia, Myeloid, Acute; Lipopeptides; Male; Microbial Sensitivity Tests; Mutation; Treatment Outcome; Triazoles; Voriconazole | 2017 |
Evaluation of Posaconazole Serum Concentrations from Delayed-Release Tablets in Patients at High Risk for Fungal Infections.
Topics: Adult; Aged; Antifungal Agents; Aspergillosis; Aspergillus; Candida; Female; Fusarium; Humans; Invasive Fungal Infections; Male; Middle Aged; Mucorales; Mucositis; Retrospective Studies; Triazoles | 2017 |
In Situ Characterization of Pharmaceutical Formulations by Dynamic Nuclear Polarization Enhanced MAS NMR.
Topics: Clotrimazole; Cyclic N-Oxides; Drug Compounding; Magnetic Resonance Spectroscopy; Pharmaceutical Preparations; Propanols; Protons; Triazoles | 2017 |
Retrospective analysis of goal drug level attainment of posaconazole for invasive fungal infection prophylaxis in patients with acute myeloid leukemia pre- and post-switch to tablet formulation.
Topics: Administration, Oral; Adult; Aged; Antifungal Agents; Case-Control Studies; Drug Administration Schedule; Drug Compounding; Female; Humans; Invasive Fungal Infections; Leukemia, Myeloid, Acute; Male; Middle Aged; Patient Care Planning; Post-Exposure Prophylaxis; Retrospective Studies; Tablets; Triazoles; Young Adult | 2018 |
Cost-Effectiveness of Posaconazole Tablets for Invasive Fungal Infections Prevention in Acute Myelogenous Leukemia or Myelodysplastic Syndrome Patients in Spain.
Topics: Adult; Aged; Antifungal Agents; Cost-Benefit Analysis; Female; Fluconazole; Humans; Invasive Fungal Infections; Itraconazole; Leukemia, Myeloid, Acute; Male; Middle Aged; Models, Economic; Myelodysplastic Syndromes; Solutions; Spain; Tablets; Triazoles | 2017 |
In Silico Modeling Approach for the Evaluation of Gastrointestinal Dissolution, Supersaturation, and Precipitation of Posaconazole.
Topics: Administration, Oral; Biopharmaceutics; Chemistry, Pharmaceutical; Computer Simulation; Drug Liberation; Gastrointestinal Tract; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Models, Biological; Models, Chemical; Solubility; Triazoles | 2017 |
Effects of Photodynamic Therapy on the Growth and Antifungal Susceptibility of Scedosporium and Lomentospora spp.
Topics: Amphotericin B; Antifungal Agents; Ascomycota; Humans; Immunocompromised Host; Itraconazole; Methylene Blue; Microbial Sensitivity Tests; Photochemotherapy; Photosensitizing Agents; Scedosporium; Triazoles; Voriconazole | 2017 |
Favorable Outcome in Coccidioides Endophthalmitis-A Combined Medical and Surgical Treatment Approach.
Topics: Adult; Amphotericin B; Antifungal Agents; Aqueous Humor; Coccidioides; Coccidioidomycosis; Combined Modality Therapy; Endophthalmitis; Eye Infections, Fungal; Female; Humans; Intravitreal Injections; Ophthalmologic Surgical Procedures; Treatment Outcome; Triazoles; Vitreous Body | 2017 |
Efficacy and safety of posaconazole in hematopoietic stem cell transplantation patients with invasive fungal disease.
Topics: Adult; Antifungal Agents; Cytomegalovirus Infections; Female; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Invasive Fungal Infections; Male; Middle Aged; Multivariate Analysis; Neutropenia; Primary Prevention; Regression Analysis; Retrospective Studies; Steroids; Time Factors; Transplantation Conditioning; Treatment Outcome; Triazoles | 2017 |
Voriconazole and posaconazole therapeutic drug monitoring: a retrospective study.
Topics: Administration, Intravenous; Administration, Oral; Adult; Antifungal Agents; Colorado; Drug Compounding; Drug Monitoring; Female; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Retrospective Studies; Treatment Outcome; Triazoles; Voriconazole | 2017 |
Retrospective Analysis of Posaconazole Suspension Dosing Strategies in a Pediatric Oncology Population: Single-Center Experience.
Topics: Adolescent; Antifungal Agents; Child; Child, Preschool; Drug Administration Schedule; Female; Humans; Male; Neoplasms; Retrospective Studies; Suspensions; Triazoles | 2017 |
A Comparative Study on the Performance of Inert and Functionalized Spheres Coated with Solid Dispersions Made of Two Structurally Related Antifungal Drugs.
Topics: Antifungal Agents; Cellulose; Itraconazole; Tartrates; Triazoles | 2017 |
Synergistic Effects of Tacrolimus and Azoles against Exophiala dermatitidis.
Topics: Antifungal Agents; Biofilms; Calcineurin Inhibitors; Candida parapsilosis; Drug Synergism; Exophiala; Humans; Itraconazole; Microbial Sensitivity Tests; Phaeohyphomycosis; Tacrolimus; Triazoles; Voriconazole | 2017 |
Pharmacodynamics of the Novel Antifungal Agent F901318 for Acute Sinopulmonary Aspergillosis Caused by Aspergillus flavus.
Topics: Acetamides; Animals; Antifungal Agents; Aspergillus flavus; Cells, Cultured; Dose-Response Relationship, Drug; Humans; Invasive Pulmonary Aspergillosis; Mice; Piperazines; Pyrimidines; Pyrroles; Triazoles; Voriconazole | 2018 |
Diversity of clinical isolates of Aspergillus terreus in antifungal susceptibilities, genotypes and virulence in Galleria mellonella model: Comparison between respiratory and ear isolates.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus; Drug Resistance, Fungal; Ear; Genotype; Hospitals, University; Humans; Itraconazole; Lepidoptera; Microsatellite Repeats; Respiratory System; Triazoles; Voriconazole | 2017 |
Allergic bronchopulmonary mycosis presenting as a new lung mass.
Topics: Aged; Anti-Inflammatory Agents; Antifungal Agents; Diagnosis, Differential; Humans; Invasive Pulmonary Aspergillosis; Lung Diseases, Fungal; Lung Neoplasms; Male; Prednisone; Tomography, X-Ray Computed; Triazoles | 2017 |
Isavuconazole susceptibility of clinical Aspergillus fumigatus isolates and feasibility of isavuconazole dose escalation to treat isolates with elevated MICs.
Topics: Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Cytochrome P-450 Enzyme System; Drug Resistance, Fungal; Fungal Proteins; Humans; Itraconazole; Microbial Sensitivity Tests; Nitriles; Pyridines; Triazoles; Voriconazole | 2018 |
Genome-wide mutagenesis and multi-drug resistance in American trypanosomes induced by the front-line drug benznidazole.
Topics: Animals; Chagas Disease; Disease Models, Animal; Drug Resistance, Multiple; Female; Genome, Protozoan; Mice, SCID; Mutagenesis; Mutagens; Mutation; Nitroimidazoles; Sequence Analysis, DNA; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2017 |
Risk factors for subtherapeutic levels of posaconazole tablet.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Antifungal Agents; Drug Monitoring; Female; Hematologic Neoplasms; Humans; Invasive Fungal Infections; Male; Middle Aged; Multivariate Analysis; Pre-Exposure Prophylaxis; Retrospective Studies; Risk Factors; Tablets; Triazoles; Young Adult | 2017 |
Urinary tract aspergillosis in a patient with chronic kidney disease.
Topics: Antifungal Agents; Aspergillosis; Combined Modality Therapy; Diagnosis, Differential; Humans; Immunocompromised Host; Male; Middle Aged; Renal Insufficiency, Chronic; Triazoles; Urinary Tract Infections | 2017 |
Posaconazole liquid vs tablet formulation in lung transplant recipients.
Topics: Administration, Oral; Adult; Aged; Antifungal Agents; Aspergillosis; Delayed-Action Preparations; Drug Monitoring; Female; Humans; Invasive Fungal Infections; Longitudinal Studies; Lung Transplantation; Male; Middle Aged; Retrospective Studies; Suspensions; Tablets; Transplant Recipients; Triazoles; Young Adult | 2018 |
Real-world challenges and unmet needs in the diagnosis and treatment of suspected invasive pulmonary aspergillosis in patients with haematological diseases: An illustrative case study.
Topics: Amphotericin B; Anemia, Aplastic; Antifungal Agents; Aspergillus; Hematologic Diseases; Humans; Invasive Pulmonary Aspergillosis; Male; Neutropenia; Nitriles; Pyridines; Transaminases; Treatment Outcome; Triazoles; Voriconazole; Young Adult | 2018 |
Salvage therapy with topical posaconazole in lung transplant recipients with invasive Scedosporium infection.
Topics: Administration, Topical; Adult; Antifungal Agents; Cystic Fibrosis; Emphysema; Female; Humans; Immunocompromised Host; Lung Transplantation; Male; Middle Aged; Mycoses; Postoperative Complications; Prognosis; Salvage Therapy; Scedosporium; Transplant Recipients; Triazoles | 2018 |
Necrotizing Microascus tracheobronchitis in a bilateral lung transplant recipient.
Topics: Amphotericin B; Antifungal Agents; Ascomycota; Bronchi; Bronchitis; Endoscopy; Female; Humans; Immunocompromised Host; Lung Transplantation; Middle Aged; Mycoses; Necrosis; Transplant Recipients; Treatment Outcome; Triazoles | 2018 |
Persistent CNS toxicity in a patient receiving posaconazole tablets after discontinuation of voriconazole due to supratherapeutic serum levels.
Topics: Antifungal Agents; Brain Diseases; Humans; Male; Middle Aged; Serum; Tablets; Triazoles; Voriconazole | 2018 |
Primary prophylaxis of invasive fungal infections with posaconazole or itraconazole in patients with acute myeloid leukaemia or high-risk myelodysplastic syndromes undergoing intensive cytotoxic chemotherapy: A real-world comparison.
Topics: Adult; Aged; Antifungal Agents; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Invasive Fungal Infections; Invasive Pulmonary Aspergillosis; Itraconazole; Leukemia, Myeloid, Acute; Male; Middle Aged; Myelodysplastic Syndromes; Pre-Exposure Prophylaxis; Retrospective Studies; Treatment Failure; Triazoles | 2018 |
Evaluation of the efficacy of a posaconazole and anidulafungin combination in a murine model of pulmonary aspergillosis due to infection with Aspergillus fumigatus.
Topics: Anidulafungin; Animals; Antifungal Agents; Aspergillus fumigatus; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Echinocandins; Female; Lung; Mice; Pulmonary Aspergillosis; Treatment Outcome; Triazoles | 2018 |
Fungal Prophylaxis with a Gastro-Resistant Posaconazole Tablet for Patients with Hematological Malignancies in the POSANANTES Study.
Topics: Adult; Aged; Antibiotic Prophylaxis; Antifungal Agents; Female; Fungi; Graft vs Host Disease; Hematologic Neoplasms; Hematopoietic Stem Cell Transplantation; Humans; Invasive Fungal Infections; Male; Middle Aged; Multivariate Analysis; Prospective Studies; Stomach; Tablets; Triazoles; Young Adult | 2018 |
Antifungal azoles itraconazole and posaconazole exhibit potent in vitro antiviral activity against clinical isolates of parechovirus A3 (Picornaviridae).
Topics: Animals; Antifungal Agents; Antiviral Agents; Cell Line; Cells, Cultured; Cytopathogenic Effect, Viral; Dose-Response Relationship, Drug; Humans; Itraconazole; Parechovirus; Picornaviridae Infections; Triazoles | 2018 |
Antifungal susceptibility testing of Candida species isolated from the immunocompromised patients admitted to ten university hospitals in Iran: comparison of colonizing and infecting isolates.
Topics: Amphotericin B; Antifungal Agents; Candida; Caspofungin; Cross-Sectional Studies; Drug Resistance, Fungal; Echinocandins; Female; Fluconazole; Hospitals, University; Humans; Immunocompromised Host; Iran; Lipopeptides; Microbial Sensitivity Tests; Triazoles; Voriconazole | 2017 |
First external quality assurance program for bloodstream Real-Time PCR monitoring of treatment response in clinical trials of Chagas disease.
Topics: Chagas Disease; Humans; Monitoring, Physiologic; Nitroimidazoles; Real-Time Polymerase Chain Reaction; Triazoles; Trypanocidal Agents | 2017 |
Early Therapeutic Drug Monitoring of Posaconazole Oral Suspension in Patients With Hematologic Malignancies.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antifungal Agents; Case-Control Studies; Drug Administration Schedule; Drug Monitoring; Female; Hematologic Neoplasms; Humans; Male; Middle Aged; Prospective Studies; Suspensions; Time Factors; Triazoles; Young Adult | 2018 |
Novel approaches to antifungal therapy.
Topics: Humans; Mycoses; Salvage Therapy; Scedosporium; Transplant Recipients; Triazoles | 2018 |
Single-centre study of therapeutic drug monitoring of posaconazole in lung transplant recipients: factors affecting trough plasma concentrations.
Topics: Administration, Oral; Adult; Aged; Antifungal Agents; Dose-Response Relationship, Drug; Drug Monitoring; Female; Humans; Lung Transplantation; Male; Middle Aged; Retrospective Studies; Suspensions; Tablets; Transplant Recipients; Triazoles | 2018 |
Toxicity of Vincristine Combined With Posaconazole in Children With Acute Lymphoblastic Leukemia.
Topics: Abdominal Pain; Adolescent; Constipation; Female; Humans; Hypertension; Muscle Weakness; Mycoses; Neuralgia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Triazoles; Vincristine | 2018 |
Azole-resistant and -susceptible Aspergillus fumigatus isolates show comparable fitness and azole treatment outcome in immunocompetent mice.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Azoles; Disease Models, Animal; Drug Resistance, Fungal; Female; Humans; Itraconazole; Lymphocyte Count; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Mutation; Spleen; Treatment Outcome; Triazoles; Virulence | 2018 |
Posaconazole oral dose and plasma levels in pediatric hematology-oncology patients.
Topics: Administration, Oral; Adolescent; Anemia, Aplastic; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Drug Administration Schedule; Drug Dosage Calculations; Female; Hematologic Neoplasms; Hematopoietic Stem Cell Transplantation; Humans; Immunologic Deficiency Syndromes; Infant; Lymphohistiocytosis, Hemophagocytic; Male; Mycoses; Remission Induction; Retrospective Studies; Survival Analysis; Transplantation, Homologous; Triazoles | 2018 |
The artificial membrane insert system as predictive tool for formulation performance evaluation.
Topics: Chemistry, Pharmaceutical; Cyclodextrins; Intestinal Absorption; Itraconazole; Membranes, Artificial; Nanoparticles; Particle Size; Permeability; Pharmaceutical Preparations; Solubility; Suspensions; Triazoles | 2018 |
Successful Treatment of Lung Aspergillus terreus Infection After a Second Hematopoietic Stem Cell Transplant in a Patient With Myelodysplastic Syndrome.
Topics: Antifungal Agents; Hematopoietic Stem Cell Transplantation; Humans; Male; Micafungin; Myelodysplastic Syndromes; Postoperative Complications; Pulmonary Aspergillosis; Remission Induction; Triazoles; Young Adult | 2019 |
CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM).
Topics: 14-alpha Demethylase Inhibitors; Amebicides; Animals; Antifungal Agents; Cell Proliferation; Central Nervous System Protozoal Infections; Disease Models, Animal; Drug Repositioning; Humans; Microscopy, Electron, Transmission; Naegleria fowleri; Nitriles; Pyridines; Sterol 14-Demethylase; Sterols; Triazoles; Trophozoites | 2017 |
The challenges of treating aspergillus abdominal aneurysm after hematopoietic cell transplant: Rapid voriconazole metabolizer.
Topics: Aneurysm, Infected; Antifungal Agents; Aspergillosis; Cytochrome P-450 CYP2C19; Hematopoietic Stem Cell Transplantation; Humans; Male; Middle Aged; Triazoles; Voriconazole | 2019 |
Candida infanticola and Candida spencermartinsiae yeasts: Possible emerging species in cancer patients.
Topics: Adolescent; Antifungal Agents; Candida; Candidiasis; Caspofungin; Child, Preschool; Echinocandins; Fluconazole; Humans; Kluyveromyces; Lipopeptides; Male; Microbial Sensitivity Tests; Middle Aged; Neoplasms; Nitriles; Opportunistic Infections; Pichia; Pyridines; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Triazoles; Voriconazole | 2018 |
Use of Intravenous Posaconazole in Hematopoietic Stem Cell Transplant Patients.
Topics: Administration, Intravenous; Allografts; Child; Gastrointestinal Diseases; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Male; Mucositis; Triazoles | 2018 |
Alternative approaches to the therapeutic drug monitoring of prophylactic posaconazole in haematology patients.
Topics: Administration, Oral; Adult; Antifungal Agents; Biological Assay; Chromatography, High Pressure Liquid; Drug Monitoring; Female; Hematologic Diseases; Humans; Male; Middle Aged; Triazoles | 2018 |
Effects of posaconazole (a strong CYP3A4 inhibitor), two new tablet formulations, and food on the pharmacokinetics of idasanutlin, an MDM2 antagonist, in patients with advanced solid tumors.
Topics: Administration, Oral; Area Under Curve; Biological Availability; Cross-Over Studies; Cytochrome P-450 CYP3A Inhibitors; Drug Compounding; Drug Interactions; Fasting; Female; Food-Drug Interactions; Humans; Male; Middle Aged; Neoplasm Staging; Neoplasms; para-Aminobenzoates; Proto-Oncogene Proteins c-mdm2; Pyrrolidines; Tablets; Therapeutic Equivalency; Triazoles | 2018 |
Prevention of Invasive Aspergillus Fungal Infections with the Suspension and Delayed-Release Tablet Formulations of Posaconazole in Patients with Haematologic Malignancies.
Topics: Adult; Aged; Antifungal Agents; Chemoprevention; Delayed-Action Preparations; Female; Hematologic Neoplasms; Humans; Invasive Pulmonary Aspergillosis; Male; Middle Aged; Plasma; Suspensions; Tablets; Treatment Outcome; Triazoles | 2018 |
Evaluation and optimized selection of supersaturating drug delivery systems of posaconazole (BCS class 2b) in the gastrointestinal simulator (GIS): An in vitro-in silico-in vivo approach.
Topics: Administration, Oral; Biological Availability; Biopharmaceutics; Chemistry, Pharmaceutical; Computer Simulation; Drug Delivery Systems; Gastrointestinal Tract; Intestinal Absorption; Permeability; Solubility; Triazoles | 2018 |
Photodynamic Inactivation Potentiates the Susceptibility of Antifungal Agents against the Planktonic and Biofilm Cells of Candida albicans.
Topics: Antifungal Agents; Biofilms; Candida albicans; Candidiasis; Fluconazole; Humans; Light; Microbial Sensitivity Tests; Photochemotherapy; Plankton; Tolonium Chloride; Triazoles | 2018 |
Comparative evaluation of different gradient diffusion tests for detection of azole resistance in Aspergillus fumigatus.
Topics: Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Azoles; Disk Diffusion Antimicrobial Tests; Drug Resistance, Fungal; Itraconazole; Microbial Sensitivity Tests; Nitriles; Pyridines; Reproducibility of Results; Triazoles; Voriconazole | 2018 |
Topics: Aged; Amphotericin B; Anti-Bacterial Agents; Antifungal Agents; Endophthalmitis; Eye; Female; Fusarium; Humans; Hyphae; Immunocompromised Host; Leukemia, Myeloid, Acute; Treatment Outcome; Triazoles; Vitrectomy; Voriconazole | 2018 |
Molecular identification and susceptibility profile of Sporothrix schenckii sensu lato isolated in Argentina.
Topics: Animals; Antifungal Agents; Argentina; Calmodulin; Flucytosine; Humans; Itraconazole; Microbial Sensitivity Tests; Phylogeny; Sequence Analysis, DNA; Soil Microbiology; Sporothrix; Sporotrichosis; Triazoles | 2018 |
Saksenaea vasiformis Orbital Cellulitis in an Immunocompetent Child Treated With Posaconazole.
Topics: Antifungal Agents; Child; Combined Modality Therapy; Debridement; Female; Humans; Immunocompetence; Mucorales; Mucormycosis; Orbital Cellulitis; Triazoles | 2018 |
S-allylmercaptocysteine attenuates posaconazole-induced adverse effects in mice through antioxidation and anti-inflammation.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antioxidants; Colon; Cysteine; Cytokines; Diarrhea; Drug-Related Side Effects and Adverse Reactions; Garlic; Humans; Inflammation Mediators; Intestinal Mucosa; Mice; Mice, Inbred Strains; Microspheres; Triazoles | 2018 |
Posaconazole-Induced Pseudohyperaldosteronism.
Topics: Aged; Antifungal Agents; Heart Failure; Histoplasmosis; Humans; Hydroxysteroid Dehydrogenases; Hyperaldosteronism; Hypertension; Hypokalemia; Mineralocorticoid Excess Syndrome, Apparent; Triazoles; Voriconazole | 2018 |
Alternate-day dosing of posaconazole tablets in children leads to efficient plasma levels.
Topics: Age Factors; Antifungal Agents; Child; Female; Humans; Immunocompromised Host; Invasive Fungal Infections; Male; Treatment Outcome; Triazoles | 2018 |
Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline.
Topics: Antibodies, Fungal; Antifungal Agents; Aspergillosis; Aspergillus; Biopsy; Bronchoalveolar Lavage; Disease Management; Early Diagnosis; Flucytosine; Galactose; Humans; Immunocompromised Host; Immunologic Tests; Invasive Pulmonary Aspergillosis; Itraconazole; Leukemia, Myeloid, Acute; Magnetic Resonance Imaging; Mannans; Microbial Sensitivity Tests; Myelodysplastic Syndromes; Nitriles; Pyridines; Tomography, X-Ray Computed; Triazoles; Voriconazole | 2018 |
Topics: Adult; Amphotericin B; Antifungal Agents; Diabetes Complications; Diabetes Mellitus; Female; Humans; Immunocompromised Host; Male; Maxillary Sinus; Middle Aged; Mucorales; Mucormycosis; Opportunistic Infections; Sinusitis; Tooth Extraction; Treatment Outcome; Triazoles | 2018 |
Measuring the Impact of Gastrointestinal Variables on the Systemic Outcome of Two Suspensions of Posaconazole by a PBPK Model.
Topics: Antifungal Agents; Bile Acids and Salts; Gastric Emptying; Gastrointestinal Tract; Humans; Hydrogen-Ion Concentration; Intestine, Small; Models, Theoretical; Organ Size; Triazoles | 2018 |
Anti-candidal activity of selected analgesic drugs used alone and in combination with fluconazole, itraconazole, voriconazole, posaconazole and isavuconazole.
Topics: Acetaminophen; Analgesics; Antifungal Agents; Aspirin; Candida; Candida albicans; Candida glabrata; Candidiasis; Dipyrone; Drug Resistance, Fungal; Fluconazole; Humans; Ibuprofen; Itraconazole; Meloxicam; Microbial Sensitivity Tests; Nitriles; Pyridines; Triazoles; Voriconazole | 2018 |
A CLADOPHIALOPHORA BRAIN ABSCESS IN A RENAL TRANSPLANT RECIPIENT.
Topics: Adult; Antifungal Agents; Ascomycota; Brain Abscess; Central Nervous System Fungal Infections; Humans; Immunocompromised Host; Kidney; Kidney Transplantation; Male; Triazoles | 2016 |
The Genetic Polymorphism UGT1A4*3 Is Associated with Low Posaconazole Plasma Concentrations in Hematological Malignancy Patients Receiving the Oral Suspension.
Topics: Administration, Oral; Adult; Aged; Alleles; Antifungal Agents; Drug Resistance, Multiple; Female; Glucuronosyltransferase; Humans; Male; Middle Aged; Multivariate Analysis; Polymorphism, Genetic; Prospective Studies; Risk Factors; Triazoles | 2018 |
Refractory Hypokalemia from Syndrome of Apparent Mineralocorticoid Excess on Low-Dose Posaconazole.
Topics: Aged; Female; Humans; Hypokalemia; Leukemia, Myeloid, Acute; Mineralocorticoid Excess Syndrome, Apparent; Potassium; Triazoles | 2018 |
Posaconazole vs. voriconazole in the prevention of invasive fungal diseases in patients with haematological malignancies: A retrospective study.
Topics: Adolescent; Adult; Aged; Antifungal Agents; Child; China; Cost-Benefit Analysis; Female; Fluconazole; Hematologic Neoplasms; Humans; Invasive Fungal Infections; Itraconazole; Male; Middle Aged; Retrospective Studies; Triazoles; Voriconazole; Young Adult | 2018 |
Clinical Pharmacokinetics and Dose Recommendations for Posaconazole in Infants and Children.
Topics: Administration, Oral; Adolescent; Antifungal Agents; Biological Availability; Child; Child, Preschool; Drug Monitoring; Humans; Immunocompromised Host; Infant; Models, Biological; Suspensions; Tablets; Triazoles | 2019 |
Enhanced delivery of fixed-dose combination of synergistic antichagasic agents posaconazole-benznidazole based on amorphous solid dispersions.
Topics: Biological Availability; Chagas Disease; Drug Carriers; Drug Combinations; Drug Liberation; Drug Synergism; Models, Molecular; Nitroimidazoles; Povidone; Pyrrolidines; Triazoles; Trypanocidal Agents; Vinyl Compounds | 2018 |
A Population Pharmacokinetic Model for a Solid Oral Tablet Formulation of Posaconazole.
Topics: Administration, Oral; Adult; Antifungal Agents; Female; Humans; Male; Middle Aged; Tablets; Triazoles | 2018 |
Isavuconazole Concentration in Real-World Practice: Consistency with Results from Clinical Trials.
Topics: Antifungal Agents; Clinical Trials as Topic; Humans; Itraconazole; Microbial Sensitivity Tests; Nitriles; Pyridines; Triazoles; Voriconazole | 2018 |
[Use of posaconazole in children: Experience in a tertiary pediatric hospital].
Topics: Adolescent; Antifungal Agents; Child; Child, Preschool; Dose-Response Relationship, Drug; Hospitals, Pediatric; Humans; Invasive Fungal Infections; Retrospective Studies; Tertiary Care Centers; Time Factors; Triazoles | 2018 |
Simultaneous quantification of systemic azoles and their major metabolites in human serum by HPLC/PDA: role of azole metabolic rate.
Topics: Antifungal Agents; Azoles; Chromatography, High Pressure Liquid; Humans; Itraconazole; Serum; Triazoles; Voriconazole | 2018 |
Sterol Composition of Clinically Relevant Mucorales and Changes Resulting from Posaconazole Treatment.
Topics: Antifungal Agents; Aspergillus fumigatus; Drug Resistance, Fungal; Ergosterol; Gas Chromatography-Mass Spectrometry; Metabolomics; Molecular Structure; Mucorales; Species Specificity; Sterols; Triazoles | 2018 |
Low dose posaconazole delayed release tablets for fungal prophylaxis in lung transplant recipients.
Topics: Antibiotic Prophylaxis; Antifungal Agents; Delayed-Action Preparations; Drug Monitoring; Female; Follow-Up Studies; Humans; Invasive Fungal Infections; Lung Transplantation; Male; Middle Aged; Prognosis; Retrospective Studies; Tablets; Tissue Distribution; Transplant Recipients; Triazoles | 2018 |
On the Nose: Disseminated Mucormycosis.
Topics: Aged; Amphotericin B; Antifungal Agents; Humans; Immunocompromised Host; Leukemia, Myeloid, Acute; Lung Diseases; Male; Mucormycosis; Nose Diseases; Pancytopenia; Treatment Outcome; Triazoles | 2018 |
TR34/L98H Mutation in CYP51A Gene in Aspergillus fumigatus Clinical Isolates During Posaconazole Prophylaxis: First Case in Korea.
Topics: Adult; Antifungal Agents; Aspergillus fumigatus; Bronchoalveolar Lavage Fluid; Chemoprevention; Cytochrome P-450 Enzyme System; Drug Resistance, Fungal; Fungal Proteins; Hematopoietic Stem Cell Transplantation; Humans; Immunocompromised Host; Invasive Pulmonary Aspergillosis; Male; Mutation, Missense; Republic of Korea; Triazoles | 2018 |
Disseminated Exophiala dermatitidis causing septic arthritis and osteomyelitis.
Topics: Adult; Amphotericin B; Antifungal Agents; Arthritis, Infectious; Exophiala; Female; Humans; Immunocompromised Host; Magnetic Resonance Imaging; Osteomyelitis; Phaeohyphomycosis; Triazoles; Voriconazole | 2018 |
A vexing case of bone pain in a renal transplant recipient: Voriconazole-induced periostitis.
Topics: Antifungal Agents; Drug Substitution; Graft Rejection; Humans; Immunocompromised Host; Invasive Pulmonary Aspergillosis; Kidney Transplantation; Male; Middle Aged; Periostitis; Transplant Recipients; Triazoles; Voriconazole | 2018 |
Assessment of posaconazole salvage therapy in chronic pulmonary aspergillosis using predefined response criteria.
Topics: Adult; Aged; Aged, 80 and over; Antifungal Agents; Aspergillus fumigatus; Chronic Disease; Female; Humans; Male; Middle Aged; Pulmonary Aspergillosis; Retrospective Studies; Salvage Therapy; Surveys and Questionnaires; Survival Analysis; Treatment Outcome; Triazoles | 2018 |
Economic impact of treating invasive mold disease with isavuconazole compared with liposomal amphotericin B in the UK.
Topics: Amphotericin B; Antifungal Agents; Aspergillosis; Costs and Cost Analysis; Drug Costs; Health Care Costs; Humans; Models, Economic; Mucormycosis; Nitriles; Pyridines; Treatment Outcome; Triazoles; United Kingdom | 2018 |
Cutaneous mucormycosis caused by Rhizopus microsporus in an immunocompetent patient: A case report and review of literature.
Topics: Adult; Antifungal Agents; Bacteriological Techniques; Dermatomycoses; Humans; Immunologic Tests; Male; Mucormycosis; Rhizopus; Treatment Outcome; Triazoles | 2018 |
Galleria mellonella as a model system to study virulence potential of mucormycetes and evaluation of antifungal treatment.
Topics: Amphotericin B; Animals; Antifungal Agents; Disease Models, Animal; Drug Resistance, Fungal; Larva; Lepidoptera; Microbial Sensitivity Tests; Mucor; Mucorales; Mucormycosis; Nitriles; Pyridines; Rhizopus; Triazoles; Virulence | 2019 |
Posaconazole inhibits dengue virus replication by targeting oxysterol-binding protein.
Topics: Animals; Antifungal Agents; Antiviral Agents; Chlorocebus aethiops; Dengue Virus; Drug Repositioning; HeLa Cells; Humans; Itraconazole; Receptors, Steroid; Triazoles; Vero Cells; Virus Replication; Zika Virus | 2018 |
Exploring gastric drug absorption in fasted and fed state rats.
Topics: Acetaminophen; Animals; Diclofenac; Fasting; Gastric Absorption; Gastric Mucosa; Male; Rats, Wistar; Triazoles | 2018 |
Impact of patient education on plasma concentrations and effectiveness of posaconazole oral suspension under clinical conditions.
Topics: Administration, Oral; Adult; Aged; Antibiotic Prophylaxis; Antifungal Agents; Antineoplastic Agents; Female; Humans; Induction Chemotherapy; Invasive Fungal Infections; Leukemia, Myeloid, Acute; Male; Middle Aged; Patient Education as Topic; Program Evaluation; Prospective Studies; Retrospective Studies; Suspensions; Treatment Outcome; Triazoles; Young Adult | 2019 |
Comparison of Antifungal Azole Interactions with Adult Cytochrome P450 3A4 versus Neonatal Cytochrome P450 3A7.
Topics: Adult; Animals; Antifungal Agents; Azoles; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Humans; Infant, Newborn; Rats; Triazoles | 2018 |
Development of Trypanosoma cruzi in vitro assays to identify compounds suitable for progression in Chagas' disease drug discovery.
Topics: Biological Assay; Chagas Disease; Drug Discovery; Ergosterol; Humans; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2018 |
Comparison of particle size methodology and assessment of nanoparticle tracking analysis (NTA) as a tool for live monitoring of crystallisation pathways.
Topics: Antifungal Agents; Chemistry, Pharmaceutical; Crystallization; Dynamic Light Scattering; Excipients; Itraconazole; Ketoconazole; Nanoparticles; Particle Size; Polyethylene Glycols; Solvents; Technology, Pharmaceutical; Triazoles | 2018 |
Clinical Outcomes of Oral Suspension versus Delayed-Release Tablet Formulations of Posaconazole for Prophylaxis of Invasive Fungal Infections.
Topics: Administration, Oral; Aged; Antifungal Agents; Female; Humans; Invasive Fungal Infections; Male; Middle Aged; Retrospective Studies; Suspensions; Triazoles | 2018 |
Pulmonary blastomycosis presenting as primary lung cancer.
Topics: Antifungal Agents; Blastomyces; Blastomycosis; Diagnosis, Differential; DNA, Fungal; Humans; Lung; Lung Neoplasms; Male; Middle Aged; Positron Emission Tomography Computed Tomography; Tomography, X-Ray Computed; Triazoles | 2018 |
A pharmacokinetic case study of intravenous posaconazole in a critically ill patient with hypoalbuminaemia receiving continuous venovenous haemodiafiltration.
Topics: Antifungal Agents; Area Under Curve; Critical Illness; Drug Administration Schedule; Drug Dosage Calculations; Hemodiafiltration; Humans; Hypoalbuminemia; Intraabdominal Infections; Male; Microbial Sensitivity Tests; Middle Aged; Sepsis; Triazoles | 2018 |
Rezafungin (CD101) demonstrates potent in vitro activity against Aspergillus, including azole-resistant Aspergillus fumigatus isolates and cryptic species.
Topics: Antifungal Agents; Aspergillus; Aspergillus fumigatus; Azoles; Drug Resistance, Fungal; Echinocandins; Humans; Microbial Sensitivity Tests; Triazoles; Voriconazole | 2018 |
(1-3)-β-D-Glucan serum increase and small-airway-invasive radiological findings as early signs of pulmonary aspergillosis in high-risk hematologic patients in the posaconazole era: preliminary observations.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; beta-Glucans; Cytarabine; Daunorubicin; Female; Humans; Idarubicin; Leukemia, Myeloid, Acute; Male; Middle Aged; Pulmonary Aspergillosis; Retrospective Studies; Risk Factors; Triazoles; Vidarabine | 2019 |
Quantification of Serum Voriconazole, Isavuconazole, and Posaconazole by Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS).
Topics: Antifungal Agents; Chromatography, Liquid; Humans; Nitriles; Pyridines; Tandem Mass Spectrometry; Triazoles; Voriconazole | 2018 |
The Outcome of Antifungal Prophylaxis with Posaconazole in Patients with Acute Myeloid Leukemia: A Single-Center Study
Topics: Administration, Oral; Adult; Aged; Antifungal Agents; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Retrospective Studies; Triazoles; Young Adult | 2018 |
Drug-Drug Interaction Between Isavuconazole and Tacrolimus: Is Empiric Dose Adjustment Necessary?
Topics: Allografts; Antifungal Agents; Drug Interactions; Drug Monitoring; Drug Tapering; Female; Humans; Immunosuppressive Agents; Middle Aged; Nitriles; Pyridines; Tacrolimus; Triazoles | 2020 |
Cutaneous mucormycosis.
Topics: Aged; Amphotericin B; Antifungal Agents; Debridement; Dermatomycoses; Humans; Male; Mucormycosis; Triazoles | 2018 |
Heterologous Expression of Full-Length Lanosterol 14α-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provides Tools for Antifungal Discovery.
Topics: Amphotericin B; Antifungal Agents; Azoles; Candida albicans; Candida glabrata; Drug Resistance, Fungal; Ergosterol; Fluconazole; Fungal Proteins; Humans; Itraconazole; Lanosterol; Microbial Sensitivity Tests; Saccharomyces cerevisiae; Sterol 14-Demethylase; Triazoles; Voriconazole | 2018 |
Crystal Structures of Full-Length Lanosterol 14α-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provide Tools for Antifungal Discovery.
Topics: Antifungal Agents; Azoles; Candida albicans; Candida glabrata; Catalytic Domain; Fluconazole; Fungal Proteins; Humans; Itraconazole; Lanosterol; Microbial Sensitivity Tests; Protein Binding; Saccharomyces cerevisiae; Sterol 14-Demethylase; Triazoles | 2018 |
Treatment of Suspected Invasive Fungal Infection in War Wounds.
Topics: Administration, Topical; Afghan Campaign 2001-; Amphotericin B; Antifungal Agents; beta-Cyclodextrins; Debridement; Excipients; Humans; Mycoses; Recurrence; Risk Factors; Tobramycin; Treatment Outcome; Triazoles; Vancomycin; Voriconazole; Wounds and Injuries | 2018 |
Tolerability of isavuconazole after posaconazole toxicity in leukaemia patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Leukemia; Liver Function Tests; Male; Middle Aged; Mycoses; Nitriles; Pyridines; Retrospective Studies; Triazoles; Young Adult | 2019 |
Necrotizing fasciitis caused by Mucor indicus in a pediatric bone marrow transplant recipient.
Topics: Amphotericin B; Bone Marrow Transplantation; Child, Preschool; Debridement; Fasciitis, Necrotizing; Female; Humans; Immunocompromised Host; Magnetic Resonance Imaging; Mucor; Risk Factors; Treatment Outcome; Triazoles | 2018 |
Renal Mucormycosis: A Rare Cause of Urinary Tract Infection Leading to End-stage Renal Disease (ESRD).
Topics: Abdominal Pain; Amphotericin B; Antifungal Agents; Child, Preschool; Dialysis; Fever; Humans; Kidney; Kidney Failure, Chronic; Magnetic Resonance Imaging; Male; Mucorales; Mucormycosis; Pyelonephritis; Treatment Outcome; Triazoles; Urinary Tract Infections; Vomiting | 2019 |
Posaconazole-digoxin drug-drug interaction mediated by inhibition of P-glycoprotein.
Topics: Aged; Antifungal Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Atrial Fibrillation; Digoxin; Drug Interactions; Female; Humans; Triazoles | 2019 |
Evaluation of Intravenous Posaconazole Dosing and Pharmacokinetic Target Attainment in Pediatric Patients.
Topics: Administration, Intravenous; Adolescent; Alanine Transaminase; Antifungal Agents; Child; Child, Preschool; Drug Monitoring; Humans; Infant; Infant, Newborn; Retrospective Studies; Triazoles | 2019 |
Diagnosis and Treatment of Invasive Aspergillus fumigatus Wound Infection Following Subtotal Colectomy for Perforated Toxic Megacolon in an Immunosuppressed Patient.
Topics: Adult; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Colectomy; Debridement; Female; Humans; Immunocompromised Host; Megacolon, Toxic; Postoperative Complications; Surgical Wound Infection; Treatment Outcome; Triazoles; Voriconazole | 2018 |
Posaconazole versus voriconazole as antifungal prophylaxis during induction therapy for acute myelogenous leukemia or myelodysplastic syndrome.
Topics: Adult; Aged; Antifungal Agents; Female; Humans; Induction Chemotherapy; Invasive Fungal Infections; Leukemia, Myeloid, Acute; Male; Middle Aged; Myelodysplastic Syndromes; Retrospective Studies; Triazoles; Voriconazole | 2019 |
Ketoconazole and Posaconazole Selectively Target HK2-expressing Glioblastoma Cells.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Energy Metabolism; Gene Expression Regulation, Neoplastic; Glioblastoma; Hexokinase; Humans; Ketoconazole; Male; Mice; Triazoles; Xenograft Model Antitumor Assays | 2019 |
Phenotypic Screens Reveal Posaconazole as a Rapidly Acting Amebicidal Combination Partner for Treatment of Primary Amoebic Meningoencephalitis.
Topics: Amphotericin B; Animals; Antiprotozoal Agents; Azithromycin; Central Nervous System Protozoal Infections; Disease Models, Animal; Drug Combinations; Drug Discovery; Drug Synergism; Female; Fluconazole; Humans; Inhibitory Concentration 50; Mice; Naegleria fowleri; Phenotype; Time Factors; Triazoles; United States; United States Food and Drug Administration | 2019 |
Application of a Dynamic Fluid and pH Model to Simulate Intraluminal and Systemic Concentrations of a Weak Base in GastroPlus
Topics: Administration, Oral; Computer Simulation; Drug Compounding; Fasting; Gastrointestinal Absorption; Gastrointestinal Tract; Humans; Hydrogen-Ion Concentration; Injections, Intravenous; Models, Biological; Solubility; Solutions; Triazoles | 2019 |
Azole Resistance Reduces Susceptibility to the Tetrazole Antifungal VT-1161.
Topics: Amino Acid Sequence; Antifungal Agents; ATP-Binding Cassette Transporters; Candida albicans; Candida glabrata; Catalytic Domain; Cloning, Molecular; Crystallography, X-Ray; Drug Resistance, Fungal; Fungal Proteins; Gene Expression; Genetic Vectors; Microbial Sensitivity Tests; Models, Molecular; Mutation; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Pyridines; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Sterol 14-Demethylase; Substrate Specificity; Tetrazoles; Triazoles | 2019 |
Isolated renal mucormycosis in a patient with Idiopathic CD4 lymphocytopenia.
Topics: Adolescent; Amphotericin B; Antifungal Agents; Combined Modality Therapy; Diagnosis, Differential; Female; Humans; Kidney; Kidney Diseases; Mucormycosis; T-Lymphocytopenia, Idiopathic CD4-Positive; Triazoles | 2018 |
Posaconazole Administration in Hospitalized Children in the United States.
Topics: Adolescent; Antifungal Agents; Child; Child, Preschool; Drug Prescriptions; Female; Hospitalization; Hospitals, Pediatric; Humans; Infant; Infant, Newborn; Male; Mycoses; Retrospective Studies; Triazoles; United States | 2019 |
APX001 and Other Gwt1 Inhibitor Prodrugs Are Effective in Experimental
Topics: Aminopyridines; Amphotericin B; Animals; Antifungal Agents; Coccidioides; Disease Models, Animal; Female; Fluconazole; Isoxazoles; Mice; Mice, Inbred C57BL; Microbial Sensitivity Tests; Pneumonia; Prodrugs; Triazoles | 2019 |
Impact of Antifungal Compounds on Viability and Anti-
Topics: Amphotericin B; Antifungal Agents; Caspofungin; Cell Survival; Deoxycholic Acid; Doxorubicin; Drug Combinations; Fluconazole; Humans; Killer Cells, Natural; Microbial Sensitivity Tests; Polyethylene Glycols; Triazoles; Voriconazole | 2019 |
Managing liver dysfunction in haematology patients: Switch antifungals, or use the tincture of time?
Topics: Adult; Aged; Antifungal Agents; Chemoprevention; Drug Substitution; Female; Humans; Leukemia, Myeloid, Acute; Liver Diseases; Liver Function Tests; Male; Middle Aged; Mycoses; Retrospective Studies; Time Factors; Triazoles; Young Adult | 2019 |
An Unusual Case of Pulmonary Mucormycosis.
Topics: Amphotericin B; Antifungal Agents; Humans; Immunocompromised Host; Kidney Transplantation; Lung Diseases, Fungal; Male; Middle Aged; Mucorales; Mucormycosis; Transplant Recipients; Triazoles | 2018 |
Outcomes and factors affecting them in patients with rhino-orbito-cerebral mucormycosis.
Topics: Adolescent; Adult; Aged; Amphotericin B; Antifungal Agents; Brain Diseases; Combined Modality Therapy; Debridement; Deoxycholic Acid; Eye Infections, Fungal; Female; Humans; Male; Middle Aged; Mucormycosis; Natural Orifice Endoscopic Surgery; Orbital Diseases; Paranasal Sinus Diseases; Retrospective Studies; Treatment Outcome; Triazoles; Young Adult | 2019 |
Yeast-like filamentous fungi: Molecular identification and in vitro susceptibility study.
Topics: Antifungal Agents; DNA, Fungal; Fluconazole; Fungi; Humans; Italy; Microbial Sensitivity Tests; Mycoses; Triazoles; Voriconazole | 2019 |
Development of posaconazole-based analogues as hedgehog signaling pathway inhibitors.
Topics: Antifungal Agents; Carcinoma, Basal Cell; Hedgehog Proteins; Humans; Molecular Dynamics Simulation; Protein Binding; Signal Transduction; Smoothened Receptor; Structure-Activity Relationship; Triazoles | 2019 |
Triazoles bind the C-terminal domain of SMO: Illustration by docking and molecular dynamics simulations the binding between SMO and triazoles.
Topics: Binding Sites; Hedgehog Proteins; Humans; Itraconazole; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Domains; Signal Transduction; Smoothened Receptor; Thermodynamics; Triazoles | 2019 |
Cutaneous mucormycosis.
Topics: Aged; Amphotericin B; Antifungal Agents; Fatal Outcome; Hematopoietic Stem Cell Transplantation; Humans; Immunocompromised Host; Invasive Fungal Infections; Male; Mucormycosis; Multiple Organ Failure; Rhizopus; Shock, Septic; Skin; Triazoles | 2019 |
Candida auris Sternal Osteomyelitis in a Man from Kenya Visiting Australia, 2015.
Topics: Aged; Antifungal Agents; Australia; Bone and Bones; Candida; Candidiasis; Chronic Disease; Fatal Outcome; Humans; Kenya; Male; Osteomyelitis; Tomography, X-Ray Computed; Travel; Triazoles; Whole Genome Sequencing | 2019 |
Understanding Compression-Induced Amorphization of Crystalline Posaconazole.
Topics: Calcium Phosphates; Calorimetry, Differential Scanning; Cellulose; Finite Element Analysis; Magnetic Resonance Spectroscopy; Molecular Structure; Particle Size; Phthalic Acids; Triazoles | 2019 |
A case of Verruconis gallopava infection in a heart transplant recipient successfully treated with posaconazole.
Topics: Antifungal Agents; Ascomycota; Heart Transplantation; Humans; Immunocompromised Host; Male; Middle Aged; Mycoses; Thorax; Tomography, X-Ray Computed; Treatment Outcome; Triazoles | 2019 |
Therapeutic drug monitoring and adverse events of delayed-release posaconazole tablets in patients with chronic pulmonary aspergillosis.
Topics: Administration, Oral; Adult; Aged; Antifungal Agents; Chronic Disease; Delayed-Action Preparations; Drug Monitoring; Female; Humans; Male; Middle Aged; Pulmonary Aspergillosis; Tablets; Treatment Outcome; Triazoles | 2019 |
Posaconazole trough concentrations are not influenced by inflammation: A prospective study.
Topics: Adult; Aged; Antifungal Agents; C-Reactive Protein; Female; Humans; Inflammation; Longitudinal Studies; Male; Middle Aged; Mycoses; Plasma; Prospective Studies; Triazoles; Young Adult | 2019 |
Novel Point Mutations in
Topics: Amino Acid Sequence; Antifungal Agents; Aspergillosis; Aspergillus; Base Sequence; Binding Sites; Cytochrome P-450 Enzyme System; Drug Resistance, Fungal; Fungal Proteins; Gene Expression; Humans; Itraconazole; Microbial Sensitivity Tests; Molecular Docking Simulation; Molecular Dynamics Simulation; Nails; Point Mutation; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Sequence Alignment; Sputum; Structural Homology, Protein; Triazoles | 2019 |
The Evolution of Azole Resistance in
Topics: Amino Acid Sequence; Antifungal Agents; Azoles; Candida albicans; Fluconazole; Fungal Proteins; Itraconazole; Mutation; Protein Binding; Sterol 14-Demethylase; Triazoles; Voriconazole | 2019 |
Serum Levels of Crushed Posaconazole Delayed-Release Tablets.
Topics: Delayed-Action Preparations; Humans; Tablets; Triazoles | 2019 |
Posaconazole for the treatment of allergic bronchopulmonary aspergillosis in patients with cystic fibrosis.
Topics: Adult; Antifungal Agents; Aspergillosis, Allergic Bronchopulmonary; Cystic Fibrosis; Disease Management; Humans; Immunoglobulin E; Retrospective Studies; Time Factors; Treatment Outcome; Triazoles; Young Adult | 2019 |
Subtherapeutic posaconazole troughs despite high-dose posaconazole tablets in a patient with terminal ileum resection.
Topics: Humans; Ileum; Leukemia; Micafungin; Myelodysplastic Syndromes; Tablets; Triazoles | 2019 |
Species distribution and antifungal drug susceptibilities of yeasts isolated from the blood samples of patients with candidemia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amphotericin B; Anidulafungin; Antifungal Agents; Candida; Candida albicans; Candida glabrata; Candida parapsilosis; Candidemia; Caspofungin; Child; Child, Preschool; Female; Fluconazole; Flucytosine; Humans; Itraconazole; Male; Micafungin; Microbial Sensitivity Tests; Middle Aged; Triazoles; Voriconazole; Young Adult | 2019 |
The impact of initiating posaconazole on tacrolimus pharmacokinetics in allogeneic stem cell transplantation.
Topics: Adult; Antifungal Agents; Drug Administration Schedule; Drug Interactions; Female; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Male; Middle Aged; Retrospective Studies; Stem Cell Transplantation; Tacrolimus; Triazoles | 2020 |
First fungemia case due to environmental yeast Wickerhamomyces myanmarensis: detection by multiplex qPCR and antifungal susceptibility.
Topics: Antifungal Agents; Child; Drug Resistance, Fungal; Fluconazole; Fungemia; Humans; Male; Microbial Sensitivity Tests; Real-Time Polymerase Chain Reaction; Saccharomycetales; Triazoles; Voriconazole | 2019 |
Posaconazole salvage therapy: The Posifi study.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antifungal Agents; Blood Chemical Analysis; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Middle Aged; Mycoses; Retrospective Studies; Salvage Therapy; Spain; Tertiary Care Centers; Treatment Outcome; Triazoles; Withholding Treatment | 2019 |
Why do lung transplant patients discontinue triazole prophylaxis?
Topics: Adult; Aged; Antifungal Agents; Drug Interactions; Female; Humans; Invasive Fungal Infections; Itraconazole; Lung Transplantation; Male; Medication Adherence; Middle Aged; Mycoses; Retrospective Studies; Triazoles; Voriconazole | 2019 |
The clinically licensed antifungal drug itraconazole inhibits influenza virus in vitro and in vivo.
Topics: A549 Cells; Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Repositioning; Human Umbilical Vein Endothelial Cells; Humans; Influenza A virus; Itraconazole; Mice; Mortality; Orthomyxoviridae Infections; Triazoles; Vero Cells; Viral Load; Virus Replication | 2019 |
Posaconazole therapy in children with cystic fibrosis and Aspergillus-related lung disease.
Topics: Adolescent; Adrenal Cortex Hormones; Antifungal Agents; Aspergillosis, Allergic Bronchopulmonary; Aspergillus; Child; Cystic Fibrosis; Female; Humans; Lung; Male; Prospective Studies; Triazoles | 2020 |
A Rare Case of Pulmonary Coinfection by Lichtheimia ramosa and Aspergillus fumigatus in a Patient With Delayed Graft Function After Renal Transplantation.
Topics: Amphotericin B; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Coinfection; Delayed Graft Function; Humans; Immunocompromised Host; Kidney Transplantation; Male; Mucorales; Mucormycosis; Respiratory Tract Infections; Triazoles | 2019 |
Topics: Amphotericin B; Antifungal Agents; Chelating Agents; Clioquinol; Microbial Sensitivity Tests; Mucorales; Phenanthrolines; Triazoles; Zinc | 2019 |
Combining amorphous solid dispersions for improved kinetic solubility of posaconazole simultaneously released from soluble PVP/VA64 and an insoluble ammonio methacrylate copolymer.
Topics: Antifungal Agents; Crystallization; Dosage Forms; Drug Liberation; Excipients; Kinetics; Polymethacrylic Acids; Pyrrolidines; Solubility; Triazoles; Vinyl Compounds | 2019 |
Comparative evaluation of isavuconazonium sulfate, voriconazole, and posaconazole for the management of invasive fungal infections in an academic medical center.
Topics: Academic Medical Centers; Adult; Aged; Antifungal Agents; Female; Humans; Invasive Fungal Infections; Male; Middle Aged; Nitriles; Pyridines; Retrospective Studies; Triazoles; Voriconazole; Young Adult | 2019 |
Antifungal Drugs Influence Neutrophil Effector Functions.
Topics: Amphotericin B; Antifungal Agents; Interleukin-8; Neutrophils; Nitriles; Phagocytosis; Pyridines; Triazoles; Voriconazole | 2019 |
Posaconazole in the treatment of refractory
Topics: Administration, Oral; Adult; Antifungal Agents; Diagnosis, Differential; Eye Infections, Fungal; Female; Humans; Keratitis; Keratoplasty, Penetrating; Paecilomyces; Recurrence; Triazoles | 2019 |
Intravenous and tablet formulation of posaconazole in antifungal therapy and prophylaxis: A retrospective, non-interventional, multicenter analysis of hematological patients treated in tertiary-care hospitals.
Topics: Administration, Intravenous; Adult; Aged; Antifungal Agents; Female; Humans; Invasive Fungal Infections; Male; Middle Aged; Retrospective Studies; Tablets; Tertiary Care Centers; Treatment Outcome; Triazoles; Young Adult | 2019 |
Overview and outcome of mucormycosis among children with cancer: Report from the Children's Cancer Hospital Egypt.
Topics: Adolescent; Amphotericin B; Antifungal Agents; Cancer Care Facilities; Child; Child, Preschool; Egypt; Female; Hematologic Neoplasms; Hospitals, Pediatric; Humans; Immunocompromised Host; Male; Mucormycosis; Neoplasms; Opportunistic Infections; Retrospective Studies; Risk Factors; Treatment Outcome; Triazoles | 2019 |
Molecular Interactions in Posaconazole Amorphous Solid Dispersions from Two-Dimensional Solid-State NMR Spectroscopy.
Topics: Carbon; Colloids; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Triazoles | 2019 |
Mucormycosis: More Than Meets the Eye!
Topics: Adult; Amphotericin B; Antifungal Agents; Cavernous Sinus Thrombosis; Debridement; Delayed Diagnosis; Diabetes Complications; Humans; Magnetic Resonance Imaging; Male; Mucormycosis; Ophthalmoplegia; Opportunistic Infections; Orbit Evisceration; Orbital Cellulitis; Sinusitis; Triazoles | 2019 |
Isavuconazole to prevent invasive fungal infection in immunocompromised adults: Initial experience at an academic medical centre.
Topics: Academic Medical Centers; Adult; Antifungal Agents; Chemoprevention; Cost-Benefit Analysis; Female; Humans; Immunocompromised Host; Inpatients; Invasive Fungal Infections; Male; Middle Aged; Nitriles; Oregon; Pyridines; Retrospective Studies; Risk Factors; Triazoles | 2019 |
Screening of the pathogen box for the identification of anti-Acanthamoeba agents.
Topics: Acanthamoeba castellanii; Amebicides; Animals; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Inhibitory Concentration 50; Mice; Pentamidine; Triazoles; Trophozoites | 2019 |
Application of HPTLC, spectrofluorimetry and differential pulse voltammetry for determination of the antifungal drug posaconazole in suspension dosage form.
Topics: Antifungal Agents; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Dosage Forms; Electrochemical Techniques; Indicators and Reagents; Reference Standards; Solvents; Spectrometry, Fluorescence; Suspensions; Triazoles | 2019 |
Posaconazole therapeutic drug monitoring in clinical practice and longitudinal analysis of the effect of routine laboratory measurements on posaconazole concentrations.
Topics: Administration, Oral; Aged; Antifungal Agents; Antimicrobial Stewardship; Clinical Laboratory Techniques; Dose-Response Relationship, Drug; Drug Monitoring; Female; Humans; Invasive Fungal Infections; Longitudinal Studies; Male; Middle Aged; Prospective Studies; Tablets; Triazoles | 2019 |
Immune reconstitution inflammatory syndrome in an HIV-infected patient with disseminated coccidioidomycosis.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-HIV Agents; Antifungal Agents; Antiretroviral Therapy, Highly Active; Coccidioidomycosis; Fluconazole; HIV Infections; Humans; Immune Reconstitution Inflammatory Syndrome; Male; Prednisone; Treatment Outcome; Triazoles | 2019 |
Population pharmacokinetics of total and unbound concentrations of intravenous posaconazole in adult critically ill patients.
Topics: Administration, Intravenous; Adult; Albumins; Antifungal Agents; Body Mass Index; Critical Illness; Female; Humans; Intensive Care Units; Male; Mass Spectrometry; Middle Aged; Plasma; Prospective Studies; Protein Binding; Severity of Illness Index; Triazoles | 2019 |
Screening the in vitro susceptibility of posaconazole in clinical isolates of Candida spp. and Aspergillus spp. and analyzing the sequence of ERG11 or CYP51A in non-wild-type isolates from China.
Topics: Antifungal Agents; Aspergillus; Candida; China; Cytochrome P-450 Enzyme System; Drug Resistance, Multiple, Fungal; Fungal Proteins; Humans; Microbial Sensitivity Tests; Mutation; Mycoses; Triazoles | 2019 |
A Revised Species Concept for Opportunistic
Topics: Amphotericin B; Antifungal Agents; Humans; Itraconazole; Microbial Sensitivity Tests; Mucor; Mucormycosis; Natamycin; Nitriles; Pyridines; Rhizopus; Species Specificity; Terbinafine; Triazoles | 2019 |
In vitro Post-Antifungal Effect of Posaconazole and Its Impact on Adhesion-Related Traits and Hemolysin Production of Oral Candida dubliniensis Isolates.
Topics: Antifungal Agents; Candida; Candidiasis, Oral; Cell Adhesion; Hemolysin Proteins; In Vitro Techniques; Microbial Sensitivity Tests; Triazoles | 2019 |
Antifungal synergy of a topical triazole, PC945, with a systemic triazole against respiratory Aspergillus fumigatus infection.
Topics: Administration, Topical; Antifungal Agents; Aspergillus fumigatus; Benzamides; Cell Line; Drug Synergism; Humans; Pulmonary Alveoli; Pulmonary Aspergillosis; Triazoles; Voriconazole | 2019 |
Impact of Triazole Therapeutic Drug Monitoring Availability and Timing.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antifungal Agents; Drug Monitoring; Female; Humans; Invasive Fungal Infections; Itraconazole; Male; Middle Aged; Retrospective Studies; Triazoles; Voriconazole; Young Adult | 2019 |
Isolation of
Topics: Anti-Bacterial Agents; Antifungal Agents; Candida; Cystic Fibrosis; Greece; Humans; Microbial Sensitivity Tests; Mycological Typing Techniques; Phylogeny; Sequence Analysis, DNA; Species Specificity; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sputum; Treatment Outcome; Triazoles; Young Adult | 2019 |
Aerosolization of Second-generation Triazoles: In Vitro Evaluation and Application in Therapy of Invasive Airway Aspergillosis.
Topics: Administration, Inhalation; Adult; Aerosols; Antifungal Agents; Aspergillosis; Bronchoscopy; Feasibility Studies; Female; Humans; Invasive Fungal Infections; Lung Transplantation; Respiratory Tract Infections; Triazoles; Voriconazole | 2019 |
Evaluation of the Gradient Concentration Strip Method for Antifungal Susceptibility Testing of Isavuconazole and Comparators for
Topics: Amphotericin B; Antifungal Agents; Azoles; Humans; Itraconazole; Microbial Sensitivity Tests; Mucorales; Nitriles; Pyridines; Triazoles | 2019 |
Posaconazole Serum Drug Levels Associated With Pseudohyperaldosteronism.
Topics: Aged; Antifungal Agents; Humans; Invasive Fungal Infections; Retrospective Studies; Triazoles | 2020 |
Extended-Interval Dosing of Rezafungin against Azole-Resistant Aspergillus fumigatus.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Azoles; Drug Resistance, Fungal; Echinocandins; Fungal Proteins; Kidney; Male; Mice; Real-Time Polymerase Chain Reaction; Triazoles | 2019 |
Invasive mucormycosis during treatment for acute lymphoblastic leukaemia-successful management of two life-threatening diseases.
Topics: Amphotericin B; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Humans; Invasive Fungal Infections; Lung Diseases, Fungal; Male; Mercaptopurine; Methotrexate; Mucorales; Mucormycosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Triazoles; Vincristine | 2020 |
Low Central Nervous System Posaconazole Concentrations during Cerebral Phaeohyphomycosis.
Topics: Antifungal Agents; Brain Abscess; Central Nervous System; Cerebral Phaeohyphomycosis; Female; Humans; Middle Aged; Triazoles | 2019 |
Plasma exposures following posaconazole delayed-release tablets in immunocompromised children and adolescents.
Topics: Administration, Oral; Adolescent; Antifungal Agents; Chemoprevention; Child; Child, Preschool; Delayed-Action Preparations; Female; Humans; Immunocompromised Host; Liver; Liver Function Tests; Male; Mycoses; Plasma; Retrospective Studies; Tablets; Triazoles | 2019 |
Successful Treatment of Recurrent Cutaneous Purpureocillium lilacinum (Paecilomyces lilacinus) Infection with Posaconazole and Surgical Debridement.
Topics: Administration, Cutaneous; Adult; Anemia, Hemolytic, Autoimmune; Antifungal Agents; Combined Modality Therapy; Debridement; Dermatomycoses; Follow-Up Studies; Humans; Immunocompromised Host; Male; Paecilomyces; Recurrence; Risk Assessment; Severity of Illness Index; Thrombocytopenia; Treatment Outcome; Triazoles | 2019 |
Identification and Antifungal Activity Profile of Candida Species Isolated from Patients with Pemphigus Vulgaris with Oral Lesions.
Topics: Adult; Amphotericin B; Antifungal Agents; Candida; Candidiasis, Oral; Disk Diffusion Antimicrobial Tests; Econazole; Female; Fluconazole; Humans; Itraconazole; Ketoconazole; Male; Pemphigus; Triazoles | 2019 |
Topics: Amphotericin B; Antifungal Agents; Drug Resistance, Fungal; Fluconazole; Fungi; Humans; Itraconazole; Microbial Sensitivity Tests; Mycoses; Triazoles; Voriconazole | 2019 |
Use of triazoles for the treatment of invasive aspergillosis: A three-year cohort analysis.
Topics: Adult; Aged; Aged, 80 and over; Antifungal Agents; Aspergillosis; Cohort Studies; Female; Humans; Invasive Fungal Infections; Male; Middle Aged; Nitriles; Pyridines; Treatment Outcome; Triazoles; Voriconazole | 2020 |
Antifungal prophylaxis with posaconazole tablet and oral suspension in patients with haematologic malignancy: Therapeutic drug monitoring, efficacy and risk factors for the suboptimal level.
Topics: Administration, Oral; Adult; Antifungal Agents; Drug Monitoring; Female; Hematologic Neoplasms; Humans; Hypoalbuminemia; Invasive Fungal Infections; Male; Middle Aged; Retrospective Studies; Risk Factors; Suspensions; Tablets; Treatment Outcome; Triazoles | 2020 |
Pulmonary Cryptococcus infections as a manifestation of idiopathic CD4 lymphocytopenia: case report and literature review.
Topics: Antifungal Agents; CD4 Lymphocyte Count; Cryptococcosis; Cryptococcus neoformans; Female; Humans; Lung; Lymphopenia; Middle Aged; Respiratory Tract Infections; Thorax; Tomography, X-Ray Computed; Triazoles | 2019 |
Interplay of Supersaturation and Solubilization: Lack of Correlation between Concentration-Based Supersaturation Measurements and Membrane Transport Rates in Simulated and Aspirated Human Fluids.
Topics: Atazanavir Sulfate; Biological Transport; Body Fluids; Chemistry, Pharmaceutical; Crystallization; Diffusion; Humans; Kinetics; Solubility; Thermodynamics; Triazoles | 2019 |
High-dose posaconazole for azole-resistant aspergillosis and other difficult-to-treat mould infections.
Topics: Adolescent; Adult; Aged; Antifungal Agents; Aspergillosis; Azoles; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Resistance, Fungal; Fungal Proteins; Humans; Likelihood Functions; Middle Aged; Mutation; Probability; Retrospective Studies; Surveys and Questionnaires; Triazoles | 2020 |
Characterization of Phase Transformations for Amorphous Solid Dispersions of a Weakly Basic Drug upon Dissolution in Biorelevant Media.
Topics: Crystallization; Drug Carriers; Drug Compounding; Drug Liberation; Hydrogen-Ion Concentration; Kinetics; Methylcellulose; Nanoparticles; Particle Size; Phase Transition; Solubility; Temperature; Triazoles | 2019 |
Azole-Associated Pseudohyperaldosteronism: A Class Effect or Azole-Specific?
Topics: Azoles; Drug Resistance, Fungal; Humans; Pharmaceutical Preparations; Triazoles | 2020 |
Reply to DiPippo and Kontoyiannis.
Topics: Humans; Pharmaceutical Preparations; Triazoles | 2020 |
Galactomannan Is a Biomarker of Fosmanogepix (APX001) Efficacy in Treating Experimental Invasive Pulmonary Aspergillosis.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Biomarkers; Galactose; Immunocompromised Host; Invasive Pulmonary Aspergillosis; Lung; Male; Mannans; Mice; Microbial Sensitivity Tests; Triazoles | 2019 |
Evaluation of posaconazole plasma concentrations achieved with the delayed-release tablets in Korean high-risk patients with haematologic malignancy.
Topics: Adult; Antifungal Agents; Biological Availability; Chromatography, Liquid; Cohort Studies; Delayed-Action Preparations; Female; Glucuronosyltransferase; Hematologic Neoplasms; Heterozygote; Humans; Liver; Male; Middle Aged; Multivariate Analysis; Pharmacogenetics; Polymorphism, Genetic; Regression Analysis; Retrospective Studies; Tablets; Tandem Mass Spectrometry; Triazoles | 2020 |
The influence of crushing amorphous solid dispersion dosage forms on the in-vitro dissolution kinetics.
Topics: Administration, Oral; Antifungal Agents; Antiviral Agents; Biological Availability; Chemistry, Pharmaceutical; Crystallization; Drug Compounding; Drug Liberation; Equivalence Trials as Topic; Itraconazole; Nitriles; Particle Size; Pyridazines; Pyrimidines; Research Design; Ritonavir; Solubility; Therapeutic Equivalency; Triazoles; X-Ray Diffraction | 2020 |
Evaluation of posaconazole antifungal prophylaxis in reducing the incidence of invasive aspergillosis in patients with acute myeloid leukemia.
Topics: Adult; Aerosols; Air Filters; Air Microbiology; Air Pollution, Indoor; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Aspergillosis; Aspergillus; Combined Modality Therapy; Environmental Exposure; Febrile Neutropenia; Female; Filtration; France; Hematopoietic Stem Cell Transplantation; Hospital Design and Construction; Hospitals, Teaching; Humans; Incidence; Invasive Fungal Infections; Kaplan-Meier Estimate; Leukemia, Myeloid, Acute; Male; Middle Aged; Prospective Studies; Retrospective Studies; Spores, Fungal; Triazoles | 2020 |
Agricultural systems as potential sources of emerging human mycoses caused by Trichoderma: a successful, common phylotype of Trichoderma longibrachiatum in the frontline.
Topics: Agriculture; Antifungal Agents; Environmental Exposure; Environmental Microbiology; Fluconazole; Humans; Itraconazole; Microbial Sensitivity Tests; Multilocus Sequence Typing; Mycological Typing Techniques; Mycoses; Phylogeny; Triazoles; Trichoderma | 2019 |
Antifungal Triazole Posaconazole Targets an Early Stage of the Parechovirus A3 Life Cycle.
Topics: Animals; Antifungal Agents; Antiviral Agents; Enterovirus; Itraconazole; Parechovirus; Triazoles | 2020 |
Surgical-site mucormycosis infection in a solid-organ transplant recipient and a concise review of the literature.
Topics: Amphotericin B; Antifungal Agents; Debridement; Fatal Outcome; Humans; Immunosuppressive Agents; Liver Transplantation; Male; Middle Aged; Mucormycosis; Shock, Septic; Surgical Wound Infection; Transplant Recipients; Triazoles | 2019 |
Alginate Oligosaccharides Affect Mechanical Properties and Antifungal Activity of Alginate Buccal Films with Posaconazole.
Topics: Adhesiveness; Administration, Buccal; Alginates; Antifungal Agents; Candida; Chemistry, Pharmaceutical; Drug Delivery Systems; Drug Liberation; Mouth Mucosa; Oligosaccharides; Polymers; Triazoles | 2019 |
Evaluation of target attainment of oral posaconazole suspension in immunocompromised children.
Topics: Antifungal Agents; Child; Humans; Infant; Invasive Fungal Infections; Retrospective Studies; Triazoles | 2020 |
Amphotericin-induced pancytopenia in a patient with rhino-orbital mucormycosis.
Topics: Adult; Amphotericin B; Antifungal Agents; Debridement; Drug Substitution; Humans; Male; Mouth Diseases; Mucormycosis; Nose Diseases; Orbital Diseases; Palate; Pancytopenia; Triazoles | 2020 |
Ultrafast
Topics: Antifungal Agents; Carbon Isotopes; Crystallography, X-Ray; Histidine; Hydrogen; Hydrogen Bonding; Magnetic Resonance Imaging; Nitrogen Isotopes; Proton Magnetic Resonance Spectroscopy; Protons; Triazoles | 2020 |
Rare Fungal Keratitis Caused by Coprinellus Radians.
Topics: Agaricales; Amphotericin B; Antifungal Agents; Corneal Transplantation; Corneal Ulcer; DNA, Fungal; DNA, Ribosomal Spacer; Eye Infections, Fungal; Female; Humans; Hyphae; Keratitis; Microbial Sensitivity Tests; Middle Aged; Triazoles | 2020 |
Separation of twelve posaconazole related stereoisomers by multiple heart-cutting chiral-chiral two-dimensional liquid chromatography.
Topics: Antifungal Agents; Chromatography, High Pressure Liquid; Stereoisomerism; Triazoles | 2020 |
Simultaneous quantitation of five triazole anti-fungal agents by paper spray-mass spectrometry.
Topics: Antifungal Agents; Dried Blood Spot Testing; Drug Monitoring; Fluconazole; Humans; Isotope Labeling; Laboratories; Limit of Detection; Paper; Reference Standards; Reproducibility of Results; Tandem Mass Spectrometry; Triazoles; Voriconazole | 2020 |
Itraconazole vs. posaconazole for antifungal prophylaxis in patients with acute myeloid leukemia undergoing intensive chemotherapy: A retrospective study.
Topics: Adult; Antifungal Agents; Antineoplastic Agents; Humans; Invasive Fungal Infections; Itraconazole; Leukemia, Myeloid, Acute; Retrospective Studies; Triazoles | 2020 |
[Cryptic Aspergillus species - a case report of chronic cavitary pulmonary Aspergillus lentulus infection in a heart transplant recipient].
Topics: Antifungal Agents; Aspergillosis; Aspergillus; Heart Transplantation; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Transplant Recipients; Triazoles; Voriconazole | 2019 |
Molecular mechanisms of posaconazole- and itraconazole-induced pseudohyperaldosteronism and assessment of other systemically used azole antifungals.
Topics: Aldosterone; Animals; Antifungal Agents; Azoles; Cricetinae; Disease Models, Animal; Drug Monitoring; HEK293 Cells; Humans; Hydrocortisone; Hyperaldosteronism; Hypertension; Hypothalamo-Hypophyseal System; Itraconazole; Mineralocorticoids; Steroid 11-beta-Hydroxylase; Steroid 17-alpha-Hydroxylase; Triazoles | 2020 |
Secondary antifungal prophylaxis in allogeneic hematopoietic stem cell transplant recipients with invasive fungal infection.
Topics: Adolescent; Adult; Allografts; Amphotericin B; Antibiotic Prophylaxis; Antifungal Agents; Caspofungin; Drug Therapy, Combination; Female; Hematopoietic Stem Cell Transplantation; Humans; Invasive Fungal Infections; Male; Middle Aged; Retrospective Studies; Treatment Outcome; Triazoles; Voriconazole; Young Adult | 2018 |
Synergistic effects of vorinostat (SAHA) and azoles against Aspergillus species and their biofilms.
Topics: Aspergillus; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Sub-Family B Member 4; Azoles; Biofilms; Drug Synergism; Gene Expression Regulation; HSP90 Heat-Shock Proteins; Itraconazole; Microbial Sensitivity Tests; Plankton; Triazoles; Voriconazole; Vorinostat | 2020 |
Efficacy of the Benznidazole+Posaconazole combination therapy in parasitemia reduction: An experimental murine model of acute Chagas.
Topics: Acute Disease; Animals; Chagas Disease; Disease Models, Animal; Disease Progression; DNA, Protozoan; Drug Therapy, Combination; Nitroimidazoles; Parasite Load; Parasitemia; Rats; Rats, Wistar; Triazoles; Trypanocidal Agents | 2020 |
Prolonged survival after disseminated Rhinocladiella infection treated with surgical excision and posaconazole.
Topics: Aged; Amphotericin B; Antifungal Agents; Arthritis, Infectious; Ascomycota; Brain Abscess; Central Nervous System Fungal Infections; Humans; Immunocompromised Host; Invasive Fungal Infections; Kidney Transplantation; Male; Treatment Outcome; Triazoles | 2020 |
Posaconazole-induced Pseudohyperaldosteronism Manifesting with Nephrotic-range Proteinuria.
Topics: Humans; Proteinuria; Triazoles | 2020 |
Novel Application of Pentabromobenzyl Column for Simultaneous Determination of Eight Antifungal Drugs Using High-performance Liquid Chromatography.
Topics: Antifungal Agents; Chromatography, High Pressure Liquid; Clotrimazole; Humans; Hydrocarbons, Brominated; Imidazoles; Ketoconazole; Liquid-Liquid Extraction; Molecular Structure; Thiophenes; Triazoles; Voriconazole | 2020 |
In vitro activity of isavuconazole versus opportunistic filamentous fungal pathogens from the SENTRY Antifungal Surveillance Program, 2017-2018.
Topics: Antifungal Agents; Aspergillosis; Aspergillus; Aspergillus fumigatus; Drug Resistance, Fungal; Fungi; Humans; Microbial Sensitivity Tests; Nitriles; Public Health Surveillance; Pyridines; Triazoles; Voriconazole | 2020 |
Rhizopus Infection in a Preterm Infant: A Novel Use of Posaconazole.
Topics: Amphotericin B; Antifungal Agents; Drug Therapy, Combination; Humans; Infant, Newborn; Infant, Premature; Male; Micafungin; Microbial Sensitivity Tests; Mucormycosis; Rhizopus; Triazoles | 2020 |
The Antifungal Drug Isavuconazole Is both Amebicidal and Cysticidal against Acanthamoeba castellanii.
Topics: 14-alpha Demethylase Inhibitors; Acanthamoeba castellanii; Amebiasis; Amebicides; Animals; Antifungal Agents; Drug Repositioning; Humans; Microbial Sensitivity Tests; Nitriles; Pyridines; Triazoles; Trophozoites | 2020 |
Optimization and Characterization of Aqueous Micellar Formulations for Ocular Delivery of an Antifungal Drug, Posaconazole.
Topics: Antifungal Agents; Drug Carriers; Micelles; Particle Size; Polyethylene Glycols; Triazoles | 2020 |
A Rare Presentation of Pulmonary Aspergillosis: Bronchial Stump Aspergillosis.
Topics: Aftercare; Antifungal Agents; Aspergillus flavus; Biopsy; Bronchial Diseases; Bronchoscopy; Female; Humans; Lung Diseases, Fungal; Middle Aged; Postoperative Complications; Pulmonary Aspergillosis; Treatment Outcome; Triazoles | 2020 |
Posaconazole delayed-release tablets in paediatric haematology-oncology patients.
Topics: Administration, Oral; Adolescent; Antifungal Agents; Child; Child, Preschool; Delayed-Action Preparations; Female; Hematologic Neoplasms; Humans; Male; Mycoses; Retrospective Studies; Tablets; Triazoles | 2020 |
Disseminated Mucormycosis Due to Saksenaea vasiformis Complex in an Immunocompetent Adult with Sustained Response to Posaconazole Treatment.
Topics: Aged; Antifungal Agents; Asian People; Back; Follow-Up Studies; Forehead; Humans; Immunocompetence; Male; Mucormycosis; Positron Emission Tomography Computed Tomography; Singapore; Skin; Thorax; Tomography, X-Ray Computed; Triazoles | 2020 |
Combination antifungal therapy for Scedosporium species in cystic fibrosis.
Topics: Adolescent; Antifungal Agents; Ascomycota; Child; Cystic Fibrosis; Drug Therapy, Combination; Female; Humans; Male; Mycoses; Retrospective Studies; Scedosporium; Terbinafine; Treatment Outcome; Triazoles | 2020 |
Voriconazole and the Risk of Keratinocyte Carcinomas Among Lung Transplant Recipients in the United States.
Topics: Aged; Antifungal Agents; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Female; Follow-Up Studies; Humans; Incidence; Itraconazole; Lung Transplantation; Male; Middle Aged; Pulmonary Aspergillosis; Skin Neoplasms; Triazoles; United States; Voriconazole | 2020 |
Atomic-Level Drug Substance and Polymer Interaction in Posaconazole Amorphous Solid Dispersion from Solid-State NMR.
Topics: Hydrogen Bonding; Magnetic Resonance Spectroscopy; Methylcellulose; Models, Molecular; Molecular Structure; Polymers; Triazoles | 2020 |
Probing the Molecular-Level Interactions in an Active Pharmaceutical Ingredient (API) - Polymer Dispersion and the Resulting Impact on Drug Product Formulation.
Topics: Clotrimazole; Drug Carriers; Drug Compounding; Drug Liberation; Elasticity; Hot Melt Extrusion Technology; Hot Temperature; Magnetic Resonance Spectroscopy; Molecular Conformation; Nifedipine; Pyrrolidines; Rheology; Structure-Activity Relationship; Triazoles; Vinyl Compounds; Viscosity | 2020 |
Disseminated Lomentospora prolificans infection in a patient on idelalisib-rituximab therapy for relapsed chronic lymphocytic leukaemia.
Topics: Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Drug Resistance, Multiple, Fungal; Drug Substitution; Fatal Outcome; Febrile Neutropenia; Female; Filgrastim; Fluconazole; Humans; Immunocompromised Host; Invasive Fungal Infections; Leukemia, Lymphocytic, Chronic, B-Cell; Middle Aged; Piperacillin, Tazobactam Drug Combination; Purines; Quinazolinones; Recurrence; Rituximab; Scedosporium; Triazoles; Valacyclovir; Vidarabine | 2020 |
Optimal oral cyclosporin dosing with concomitant posaconazole post allogeneic stem cell transplantation.
Topics: Antifungal Agents; Cyclosporine; Hematopoietic Stem Cell Transplantation; Humans; Mycoses; Retrospective Studies; Triazoles | 2020 |
Molecular packing of pharmaceuticals analyzed with paramagnetic relaxation enhancement and ultrafast magic angle pinning NMR.
Topics: Copper; Density Functional Theory; Fluorine; Magnetic Resonance Spectroscopy; Molecular Structure; Protons; Triazoles | 2020 |
Comparative immunopathogenesis in a murine model of inhalative infection with the mucormycetes Lichtheimia corymbifera and Rhizopus arrhizus.
Topics: Animals; Disease Models, Animal; Female; Inhalation; Mice; Mice, Inbred C57BL; Mucorales; Mucormycosis; Rhizopus; Survival Analysis; Triazoles | 2020 |
In vitro antifungal susceptibility of Sporothrix globosa isolates from Jilin Province, northeastern China: comparison of yeast and mycelial phases.
Topics: Amphotericin B; Antifungal Agents; China; Fluconazole; Humans; Itraconazole; Microbial Sensitivity Tests; Mycelium; Phylogeny; Saccharomyces cerevisiae; Sporothrix; Sporotrichosis; Terbinafine; Triazoles | 2021 |
Effect of Posaconazole in an in vitro model of cardiac fibrosis induced by Trypanosoma cruzi.
Topics: Animals; Cell Culture Techniques; Chagas Cardiomyopathy; Endomyocardial Fibrosis; Extracellular Matrix Proteins; Fetus; Fibronectins; Gene Expression Regulation; Humans; Inhibitory Concentration 50; Laminin; Mice; Models, Biological; Myocytes, Cardiac; Parasite Load; Primary Cell Culture; Tissue Inhibitor of Metalloproteinase-4; Tissue Inhibitor of Metalloproteinases; Transforming Growth Factor beta; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Successful treatment of cutaneous mucormycosis disseminated from pulmonary mucormycosis with liposomal amphotericin B and posaconazole.
Topics: Amphotericin B; Antifungal Agents; Humans; Mucormycosis; Triazoles | 2020 |
Venetoclax plus cytochrome P450 inhibitors without ramp-up strategy led to low risk of tumor lysis syndrome in acute myeloid leukemia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Bridged Bicyclo Compounds, Heterocyclic; Child; Creatinine; Cytochrome P-450 Enzyme Inhibitors; Drug Administration Schedule; Drug Synergism; Female; Humans; Hyperuricemia; Leukemia, Myeloid, Acute; Male; Middle Aged; Retrospective Studies; Sulfonamides; Triazoles; Tumor Lysis Syndrome; Urate Oxidase; Uric Acid; Young Adult | 2020 |
Initial posaconazole dosing to achieve therapeutic serum posaconazole concentrations among children, adolescents, and young adults receiving delayed-release tablet and intravenous posaconazole.
Topics: Administration, Oral; Adolescent; Antifungal Agents; Body Weight; Child; Child, Preschool; Delayed-Action Preparations; Female; Hematologic Diseases; Humans; Immunocompromised Host; Infusions, Intravenous; Invasive Fungal Infections; Male; Neoplasms; Retrospective Studies; Tablets; Treatment Outcome; Triazoles; Young Adult | 2020 |
Transcriptional response of
Topics: Amphotericin B; Antifungal Agents; Drug Resistance, Fungal; Fungal Proteins; Fusarium; Gene Expression Regulation, Bacterial; Reproducibility of Results; Species Specificity; Transcriptome; Triazoles | 2020 |
Successful challenge of voriconazole in a patient with posaconazole-associated minor drug eruption: A case report.
Topics: Adult; Antifungal Agents; Diagnosis, Differential; Drug Eruptions; Female; Humans; Invasive Fungal Infections; Leukemia, Myeloid, Acute; Triazoles; Voriconazole | 2020 |
Novel structural CYP51 mutation in Trypanosoma cruzi associated with multidrug resistance to CYP51 inhibitors and reduced infectivity.
Topics: 14-alpha Demethylase Inhibitors; Animals; Cell Line; Chagas Disease; Drug Resistance, Multiple; Genes, Protozoan; Mutation; Nitroimidazoles; Sterol 14-Demethylase; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
The Clinically Approved Antifungal Drug Posaconazole Inhibits Human Cytomegalovirus Replication.
Topics: Antifungal Agents; Antiviral Agents; Cytomegalovirus; Cytomegalovirus Infections; Ganciclovir; Humans; Pharmaceutical Preparations; Triazoles; Virus Replication | 2020 |
PBPK modeling of CYP3A and P-gp substrates to predict drug-drug interactions in patients undergoing Roux-en-Y gastric bypass surgery.
Topics: Acetaminophen; Administration, Oral; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B; Biological Availability; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Digoxin; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Gastric Bypass; Gastrointestinal Absorption; Hepatobiliary Elimination; Humans; Intestinal Elimination; Metabolic Clearance Rate; Midazolam; Models, Biological; Obesity, Morbid; Postoperative Period; Triazoles; Verapamil | 2020 |
Non-invasive monitoring of drug action: A new live in vitro assay design for Chagas' disease drug discovery.
Topics: Chagas Disease; Drug Discovery; Humans; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Duration of posaconazole therapy for Aspergillus fumigatus osteomyelitis dictated by serial monitoring of 1,3-beta-D glucan.
Topics: Adult; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Baltimore; beta-Glucans; Humans; Male; Osteomyelitis; Treatment Outcome; Triazoles | 2020 |
Evaluating posaconazole dosing regimens of the different formulations against Aspergillus spp. in adults: a pharmacokinetic/pharmacodynamic analysis using Monte Carlo simulation.
Topics: Antifungal Agents; Aspergillosis; Aspergillus; Delayed-Action Preparations; Humans; Invasive Fungal Infections; Microbial Sensitivity Tests; Triazoles | 2020 |
Posaconazole and fluconazole prophylaxis during induction therapy for pediatric acute lymphoblastic leukemia.
Topics: Antibiotic Prophylaxis; Antifungal Agents; Child; Child, Preschool; Female; Fluconazole; Humans; Induction Chemotherapy; Invasive Fungal Infections; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Retrospective Studies; Treatment Outcome; Triazoles | 2021 |
Management of posaconazole-induced pseudohyperaldosteronism.
Topics: Adult; Antifungal Agents; Humans; Retrospective Studies; Triazoles | 2020 |
Novel High-Drug-Loaded Amorphous Dispersion Tablets of Posaconazole;
Topics: Administration, Oral; Animals; Antifungal Agents; Area Under Curve; Biological Availability; Crystallization; Dogs; Drug Compounding; Drug Liberation; Models, Animal; Solubility; Spray Drying; Suspensions; Tablets; Triazoles | 2020 |
Experience using intravenous posaconazole in paediatric and young adult oncology patients.
Topics: Administration, Oral; Adolescent; Adult; Antifungal Agents; Child; Child, Preschool; Humans; Infant; Neoplasms; Retrospective Studies; Triazoles; Young Adult | 2020 |
Long term follow-up of Trypanosoma cruzi infection and Chagas disease manifestations in mice treated with benznidazole or posaconazole.
Topics: Administration, Oral; Animals; Chagas Disease; Disease Models, Animal; Follow-Up Studies; Male; Mice, Inbred C57BL; Nitroimidazoles; Polymerase Chain Reaction; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Antifungal susceptibility profile and molecular identification of Cyp51C mutations in clinical and environmental isolates of Aspergillus flavus from Argentina.
Topics: Amphotericin B; Antifungal Agents; Argentina; Aspergillosis; Aspergillus flavus; Cytochrome P450 Family 51; Drug Resistance, Fungal; Environmental Microbiology; Environmental Monitoring; Genes, Fungal; Humans; Itraconazole; Microbial Sensitivity Tests; Mutation; Triazoles; Voriconazole | 2021 |
Latest Thoughts on Treating Pediatric Mucormycosis.
Topics: Amphotericin B; Antifungal Agents; Biopsy; Child; Debridement; Humans; Immunocompromised Host; Invasive Fungal Infections; Mucorales; Mucormycosis; Salvage Therapy; Tomography, X-Ray Computed; Triazoles | 2020 |
Dementia-Like Symptoms Associated With Posaconazole.
Topics: Antifungal Agents; Dementia; Humans; Triazoles; Voriconazole | 2022 |
Attainment of therapeutic posaconazole serum levels during co-administration with rifampicin.
Topics: Antifungal Agents; Rifampin; Triazoles | 2020 |
Differential Impacts of Azole Antifungal Drugs on the Pharmacokinetic Profiles of Dasatinib in Rats by LC-MS-MS.
Topics: Administration, Oral; Animals; Antifungal Agents; Area Under Curve; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dasatinib; Drug Interactions; Drug Monitoring; Humans; Itraconazole; Ketoconazole; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Models, Animal; Protein Kinase Inhibitors; Rats; Tandem Mass Spectrometry; Triazoles; Voriconazole | 2020 |
Diagnosis of oesophageal mucormycosis managed with medical therapy alone.
Topics: Amphotericin B; Antifungal Agents; Cytarabine; Esophageal Diseases; Esophagus; Humans; Idarubicin; Immunocompromised Host; Induction Chemotherapy; Leukemia, Myeloid, Acute; Male; Middle Aged; Mucormycosis; Rhizopus; Triazoles | 2020 |
Molecular identification, biofilm formation and antifungal susceptibility of Rhodotorula spp.
Topics: Amphotericin B; Antifungal Agents; Biofilms; Caspofungin; DNA, Fungal; DNA, Ribosomal Spacer; Fluconazole; Humans; Imidazoles; Itraconazole; Microbial Sensitivity Tests; Phylogeny; Rhodotorula; Species Specificity; Triazoles; Voriconazole | 2020 |
Posaconazole aggravates vincristine-related hypertension in children with acute lymphoblastic leukemia: a case report.
Topics: Child; Humans; Hypertension; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Triazoles; Vincristine | 2020 |
Posaconazole-induced Pseudohyperaldosteronism.
Topics: Aged, 80 and over; Fungi; Humans; Hyperaldosteronism; Male; Triazoles | 2021 |
Case Report: Successful Treatment of Pulmonary Talaromyces marneffei Infection with Posaconazole in a Renal Transplant Recipient.
Topics: Adult; Antifungal Agents; Humans; Immunocompromised Host; Kidney Transplantation; Lung; Male; Mycoses; Respiratory Tract Infections; Talaromyces; Tomography, X-Ray Computed; Transplant Recipients; Triazoles | 2020 |
In vitro susceptibility to benznidazole, nifurtimox and posaconazole of Trypanosoma cruzi isolates from Paraguay
Topics: Analysis of Variance; Genotype; Lethal Dose 50; Nifurtimox; Nitroimidazoles; Paraguay; Phenotype; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
A Novel Cryptococcal Meningitis Therapy: The Combination of Amphotericin B and Posaconazole Promotes the Distribution of Amphotericin B in the Brain Tissue.
Topics: Amphotericin B; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; Blood-Brain Barrier; Brain; Cryptococcus neoformans; Dibenzocycloheptenes; Diketopiperazines; Disease Models, Animal; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Meningitis, Cryptococcal; Mice; Molecular Docking Simulation; Quinolines; Serum Albumin; Tissue Distribution; Triazoles | 2020 |
Sample Preparation of Posaconazole Oral Suspensions for Identification of the Crystal Form of the Active Pharmaceutical Ingredient.
Topics: Administration, Oral; Chemistry, Pharmaceutical; Polymethyl Methacrylate; Suspensions; Triazoles | 2020 |
Clinical considerations on posaconazole administration and therapeutic drug monitoring in allogeneic hematopoietic cell transplant recipients.
Topics: Adolescent; Adult; Aged; Drug Monitoring; Female; Hematopoietic Stem Cell Transplantation; Humans; Male; Middle Aged; Prospective Studies; Retrospective Studies; Transplant Recipients; Treatment Outcome; Triazoles; Young Adult | 2021 |
Species-specific differences in the inhibition of 11β-hydroxysteroid dehydrogenase 2 by itraconazole and posaconazole.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Antifungal Agents; Dose-Response Relationship, Drug; Enzyme Inhibitors; HEK293 Cells; Humans; Itraconazole; Mineralocorticoid Excess Syndrome, Apparent; Protein Conformation; Species Specificity; Structure-Activity Relationship; Triazoles; Zebrafish Proteins | 2021 |
[Treatment of chromoblastomycosis and phaeohyphomycosis].
Topics: Antifungal Agents; Chromoblastomycosis; Humans; Nitriles; Phaeohyphomycosis; Pyridines; Triazoles | 2020 |
Dose adjustment of venetoclax when co-administered with posaconazole: clinical drug-drug interaction predictions using a PBPK approach.
Topics: Adult; Bridged Bicyclo Compounds, Heterocyclic; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Humans; Middle Aged; Models, Biological; Sulfonamides; Triazoles | 2021 |
Analytical Study of the Antifungal Posaconazole in Raw Material: Quantitative Bioassay, Decomposition Chemical Kinetics, and Degradation Impurities by LC-QTOF-MS.
Topics: Antifungal Agents; Biological Assay; Chromatography, High Pressure Liquid; Chromatography, Liquid; Drug Stability; Kinetics; Mass Spectrometry; Triazoles | 2021 |
Pharmacokinetics and target attainment of intravenous posaconazole in critically ill patients during extracorporeal membrane oxygenation.
Topics: Administration, Intravenous; Antifungal Agents; Critical Illness; Extracorporeal Membrane Oxygenation; Humans; Triazoles | 2021 |
Is Posaconazole Really Effective in Adolescent patients as a Prophylactic Agent: Experience of a Tertiary Care Center.
Topics: Adolescent; Antifungal Agents; Fanconi Anemia; Female; Hematopoietic Stem Cell Transplantation; Humans; Kaplan-Meier Estimate; Leukemia, Myeloid, Acute; Male; Mycoses; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Tertiary Care Centers; Triazoles | 2021 |
A Population Pharmacokinetic Modeling and Simulation Study of Posaconazole Oral Suspension in Immunocompromised Pediatric Patients: A Short Communication.
Topics: Administration, Oral; Antifungal Agents; Child; Humans; Immunocompromised Host; Invasive Fungal Infections; Prospective Studies; Triazoles | 2021 |
Oral posaconazole and bronchoscopy as a treatment for pulmonary mucormycosis in pediatric acute lymphoblastic leukemia patient: A case report.
Topics: Administration, Oral; Antifungal Agents; Child; Diagnosis, Differential; Fever; Humans; Immunocompromised Host; Lung Diseases, Fungal; Male; Mucormycosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Triazoles | 2021 |
Investigating the impact of posaconazole prophylaxis on systematic fungal screening using galactomannan antigen, Aspergillus fumigatus qPCR, and Mucorales qPCR.
Topics: Aspergillus fumigatus; Galactose; Humans; Invasive Fungal Infections; Mannans; Mass Screening; Mucorales; Real-Time Polymerase Chain Reaction; Retrospective Studies; Triazoles | 2021 |
Pharmacological corrections of the mutant hERG channels by posaconazole.
Topics: Electrophysiological Phenomena; Ether-A-Go-Go Potassium Channels; HEK293 Cells; Heterozygote; Humans; Long QT Syndrome; Patch-Clamp Techniques; Triazoles | 2021 |
Radiology quiz- dancing ball.
Topics: Anti-Bacterial Agents; Antifungal Agents; Diagnosis, Differential; Drug Therapy, Combination; Hemoptysis; Humans; Klebsiella Infections; Klebsiella pneumoniae; Lung Diseases, Fungal; Male; Middle Aged; Pneumonia, Bacterial; Radiography, Thoracic; Triazoles | 2021 |
Choosing Antifungals for the Midostaurin-Treated Patient: Does CYP3A4 Outweigh Recommendations? A Brief Insight from Real Life.
Topics: Adult; Aged; Antifungal Agents; Antineoplastic Agents; Cytochrome P-450 CYP3A; Diarrhea; Female; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Mutation; Mycoses; Staurosporine; Triazoles | 2021 |
Identification and in vitro antifungal susceptibility of causative agents of onychomycosis due to Aspergillus species in Mashhad, Iran.
Topics: Antifungal Agents; Aspergillus; Calmodulin; Fungal Proteins; Humans; Iran; Microbial Sensitivity Tests; Nitriles; Onychomycosis; Pyridines; Sequence Analysis, DNA; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Triazoles; Tubulin; Voriconazole | 2021 |
Therapeutic drug monitoring is necessary for patients receiving posaconazole tablet.
Topics: Administration, Oral; Antifungal Agents; Drug Monitoring; Humans; Tablets; Triazoles | 2021 |
Posaconazole micelles for ocular delivery: in vitro permeation, ocular irritation and antifungal activity studies.
Topics: Animals; Antifungal Agents; Chickens; Eye Infections, Fungal; Female; Keratitis; Micelles; Suspensions; Triazoles | 2022 |
Frequency of occurrence, seasonal variation and antifungal susceptibility of opportunistic Mucorales isolated from hospital soils in Iran.
Topics: Amphotericin B; Antifungal Agents; Cunninghamella; Hospitals; Humans; Iran; Microbial Sensitivity Tests; Mucor; Mucorales; Mucormycosis; Opportunistic Infections; Rhizopus; Seasons; Soil; Soil Microbiology; Triazoles | 2021 |
Hypercalcemia associated with the interaction between all trans retinoic acid and posaconazole in an acute promyelocytic leukemia case.
Topics: Female; Humans; Hypercalcemia; Leukemia, Promyelocytic, Acute; Middle Aged; Tretinoin; Triazoles | 2021 |
Establishment and Verification of UPLC-MS/MS Technique for Pharmacokinetic Drug-Drug Interactions of Selinexor with Posaconazole in Rats.
Topics: Animals; Chromatography, High Pressure Liquid; Hydrazines; Male; Molecular Structure; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Triazoles | 2021 |
Subtherapeutic posaconazole prophylaxis in a gastric bypass patient following hematopoietic stem cell transplantation.
Topics: Antifungal Agents; Gastric Bypass; Hematopoietic Stem Cell Transplantation; Humans; Male; Middle Aged; Triazoles | 2021 |
Solubilizing temperature of crystalline drug in polymer carrier: A rheological investigation on a posaconazole-copovidone system with low drug load.
Topics: Chemistry, Pharmaceutical; Drug Carriers; Drug Compounding; Polymers; Pyrrolidines; Rheology; Solubility; Temperature; Triazoles; Vinyl Compounds; Viscosity | 2021 |
Clinical utility of antifungal susceptibility testing in patients with fungal rhinosinusitis.
Topics: Amphotericin B; Antifungal Agents; Aspergillosis; Aspergillus; Azoles; Humans; Itraconazole; Microbial Sensitivity Tests; Mucormycosis; Mycoses; Sinusitis; Triazoles; Voriconazole | 2021 |
Repurposing potential of posaconazole and grazoprevir as inhibitors of SARS-CoV-2 helicase.
Topics: Amides; Antiviral Agents; Carbamates; COVID-19 Drug Treatment; Cyclopropanes; Drug Repositioning; Enzyme Inhibitors; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Domains; Quinoxalines; RNA Helicases; SARS-CoV-2; Sulfonamides; Triazoles; Viral Proteins | 2021 |
Comparison of invasive fungal diseases between patients with acute myeloid leukemia receiving posaconazole prophylaxis and those not receiving prophylaxis: A single-center, observational, case-control study in South Korea.
Topics: Adult; Antibiotic Prophylaxis; Antifungal Agents; Case-Control Studies; Female; Humans; Incidence; Induction Chemotherapy; Invasive Fungal Infections; Leukemia, Myeloid, Acute; Male; Middle Aged; Remission Induction; Seoul; Treatment Outcome; Triazoles | 2021 |
Development of UPLC-MS/MS Method for Studying the Pharmacokinetic Interaction Between Dasatinib and Posaconazole in Rats.
Topics: Animals; Chromatography, High Pressure Liquid; Dasatinib; Equipment Design; Male; Molecular Structure; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Triazoles | 2021 |
Model-based assessments of CYP3A-mediated drug-drug interaction risk of milademetan.
Topics: Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Humans; Indoles; Itraconazole; Pyridines; Pyrrolidines; Risk Assessment; Triazoles | 2021 |
Mucormycosis in patients with COVID-19: A cross-sectional descriptive multicentre study from Iran.
Topics: Adolescent; Adult; Aged; Amphotericin B; Antifungal Agents; Caspofungin; Coinfection; Comorbidity; COVID-19; COVID-19 Drug Treatment; Cross-Sectional Studies; Diabetes Complications; Diabetes Mellitus; Drug Therapy, Combination; Female; Humans; Iran; Male; Middle Aged; Mucormycosis; Respiratory Distress Syndrome; Triazoles; Young Adult | 2021 |
Comparing posaconazole and itraconazole for antifungal prophylaxis in critically ill lung transplant recipients: Efficacy and plasma concentrations.
Topics: Antifungal Agents; Critical Illness; Humans; Itraconazole; Lung; Retrospective Studies; Transplant Recipients; Triazoles | 2021 |
Comparison of Disc Diffusion, Etest, and a Modified CLSI Broth Microdilution Method for
Topics: Antifungal Agents; Disk Diffusion Antimicrobial Tests; Itraconazole; Madurella; Microbial Sensitivity Tests; Triazoles; Voriconazole | 2021 |
Comparative effects of fluconazole, posaconazole, and isavuconazole upon tacrolimus and cyclosporine serum concentrations.
Topics: Antifungal Agents; Cyclosporine; Fluconazole; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Nitriles; Pyridines; Retrospective Studies; Tacrolimus; Triazoles | 2022 |
Impact of antifungal stewardship interventions on the susceptibility of colonized Candida species in pediatric patients with malignancy.
Topics: Adolescent; Amphotericin B; Antifungal Agents; Antimicrobial Stewardship; Candida; Caspofungin; Child; Child, Preschool; Colony Count, Microbial; Disease Susceptibility; Drug Resistance, Fungal; Female; Fluconazole; Humans; Male; Microbial Sensitivity Tests; Neoplasms; Triazoles | 2021 |
In vitro activity of posaconazole and comparators versus opportunistic filamentous fungal pathogens globally collected during 8 years.
Topics: Antifungal Agents; Azoles; Drug Resistance, Fungal; Europe; Fungi; Humans; Microbial Sensitivity Tests; Mycoses; North America; Opportunistic Infections; Triazoles; Voriconazole | 2021 |
Real-world assessment of the effectiveness of posaconazole for the prophylaxis and treatment of invasive fungal infections in hematological patients: A retrospective observational study.
Topics: Adult; Antifungal Agents; Female; Hematologic Diseases; Humans; Invasive Fungal Infections; Male; Middle Aged; Retrospective Studies; Triazoles; Young Adult | 2021 |
Suboptimal plasma concentrations with posaconazole suspension as prophylaxis in critically ill COVID-19 patients at risk of Covid-associated pulmonary aspergillosis.
Topics: Antifungal Agents; COVID-19; Critical Illness; Humans; Pulmonary Aspergillosis; Triazoles | 2022 |
Clinical pharmacokinetics and dose recommendations for posaconazole gastroresistant tablets in children with cystic fibrosis.
Topics: Adolescent; Child; Cystic Fibrosis; Drug Monitoring; Humans; Tablets; Triazoles | 2021 |
High-Dose Oral Posaconazole for the Treatment of Recalcitrant Fungal Keratitis.
Topics: Antifungal Agents; Corneal Ulcer; Eye Infections, Fungal; Humans; Triazoles | 2022 |
Efficacy of Posaconazole against Rhizopus oryzae Infection in Silkworm.
Topics: Animals; Antifungal Agents; Bombyx; Humans; Mucormycosis; Rhizopus; Rhizopus oryzae; Triazoles | 2021 |
Antifungal prophylaxis for prevention of COVID-19-associated pulmonary aspergillosis in critically ill patients: an observational study.
Topics: Aged; Antifungal Agents; COVID-19; Critical Illness; Female; Humans; Intensive Care Units; Male; Middle Aged; Pulmonary Aspergillosis; Respiratory Distress Syndrome; Triazoles | 2021 |
Effect of High-Dose Posaconazole on Serum Levels in Adult Patients with Hematologic Malignancy.
Topics: Administration, Oral; Adult; Antifungal Agents; Hematologic Neoplasms; Humans; Retrospective Studies; Triazoles | 2021 |
In Vitro-In Vivo Correlation in Cocrystal Dissolution: Consideration of Drug Release Profiles Based on Coformer Dissolution and Absorption Behavior.
Topics: 4-Aminobenzoic Acid; Adjuvants, Pharmaceutic; Administration, Oral; Animals; Chemistry, Pharmaceutical; Crystallization; Drug Compounding; Drug Liberation; Gastrointestinal Absorption; Itraconazole; Ketoconazole; Male; Rats; Solubility; Triazoles | 2021 |
Azole resistance in Aspergillus fumigatus isolates from respiratory specimens in Lyon University Hospitals, France: prevalence and mechanisms involved.
Topics: Antifungal Agents; Aspergillus fumigatus; Cross-Sectional Studies; Cytochrome P-450 Enzyme System; France; Fungal Proteins; Hospitals, University; Humans; Itraconazole; Microbial Sensitivity Tests; Nitriles; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Pyridines; Respiratory Tract Infections; Retrospective Studies; Triazoles; Tubulin; Voriconazole | 2021 |
Posaconazole treatment of refractory coccidioidomycosis in dogs.
Topics: Animals; Antifungal Agents; Coccidioidomycosis; Dog Diseases; Dogs; Fluconazole; Retrospective Studies; Triazoles | 2021 |
Evaluation of Voriconazole and Posaconazole Dosing in Patients With Thermal Burn Injuries.
Topics: Adult; Antifungal Agents; Azoles; Burns; Humans; Retrospective Studies; Triazoles; Voriconazole | 2022 |
Population pharmacokinetics of a posaconazole tablet formulation in transplant adult allogeneic stem cell recipients.
Topics: Antifungal Agents; Female; Hematopoietic Stem Cell Transplantation; Humans; Male; Tablets; Triazoles | 2022 |
Evaluating posaconazole, its pharmacology, efficacy and safety for the prophylaxis and treatment of fungal infections.
Topics: Adolescent; Antifungal Agents; Humans; Immunocompromised Host; Mycoses; Triazoles | 2022 |
Successful treatment of pulmonary mucormycosis caused by Rhizopus microsporus with posaconazole.
Topics: Adult; Antifungal Agents; Humans; Lung; Lung Diseases; Male; Mucormycosis; Rhizopus; Treatment Outcome; Triazoles | 2021 |
Pilot study of dogs with suppurative and non-suppurative Malassezia otitis: A case series.
Topics: Animals; Anti-Inflammatory Agents; Antifungal Agents; Dermatitis; Dog Diseases; Dogs; Ear Canal; Exudates and Transudates; Hypersensitivity; Immunoglobulin E; Intradermal Tests; Ketoconazole; Malassezia; Mometasone Furoate; Neutrophils; Otitis; Otitis Media, Suppurative; Prednisolone; Treatment Outcome; Triazoles | 2021 |
Posaconazole inhibits multiple steps of the alphavirus replication cycle.
Topics: Alphavirus; Animals; Antiviral Agents; Cell Line; Chikungunya virus; Chlorocebus aethiops; Cricetinae; Drug Repositioning; Endocytosis; Humans; Semliki forest virus; Sindbis Virus; Triazoles; Vero Cells; Virus Internalization; Virus Replication | 2022 |
[Efficacy of Posaconazole for Primary Prophylaxis in the Induction Therapy of Childhood Acute Lymphoblastic Leukemia].
Topics: Antifungal Agents; Child; Humans; Induction Chemotherapy; Mycoses; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Prevention; Triazoles | 2021 |
Therapeutic drug monitoring of posaconazole delayed release tablet while managing COVID-19-associated mucormycosis in a real-life setting.
Topics: Administration, Oral; Antifungal Agents; COVID-19; Drug Monitoring; Female; Humans; Male; Middle Aged; Mucormycosis; Pandemics; Retrospective Studies; SARS-CoV-2; Tablets; Triazoles | 2022 |
Topics: Antifungal Agents; Aspergillus; Azoles; Candida; Candida albicans; Drug Resistance, Fungal; Exophiala; Fungi; Humans; Itraconazole; Microbial Sensitivity Tests; Morpholines; Sirolimus; TOR Serine-Threonine Kinases; Triazoles; Voriconazole | 2022 |
Papilledema and idiopathic intracranial hypertension due to the possible potentiation of ATRA by posaconazole in a case of acute promyelocytic leukemia.
Topics: Adult; Fluconazole; Humans; Leukemia, Promyelocytic, Acute; Male; Papilledema; Pseudotumor Cerebri; Tretinoin; Triazoles; Voriconazole; Young Adult | 2022 |
Enteral feeding tube administration with therapeutic drug monitoring of crushed posaconazole tablets and opened isavuconazonium sulfate capsules.
Topics: Administration, Oral; Antifungal Agents; Capsules; Drug Monitoring; Enteral Nutrition; Humans; Nitriles; Pyridines; Retrospective Studies; Suspensions; Tablets; Triazoles | 2022 |
Posaconazole-induced podocyte phospholipidosis.
Topics: Humans; Lipidoses; Podocytes; Triazoles | 2022 |
Hepatic safety of the antifungal triazole agent posaconazole: characterization of adverse event reports in a manufacturer's safety database.
Topics: Antifungal Agents; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adverse Reactions; Humans; Invasive Fungal Infections; Triazoles | 2022 |
Interaction between posaconazole and flucloxacillin in a lung transplant patient: decrease in plasma exposure of posaconazole and possible undertreatment of invasive aspergillosis: case report.
Topics: Antifungal Agents; Aspergillosis; Floxacillin; Humans; Lung Transplantation; Male; Middle Aged; Triazoles | 2022 |
Posaconazole or isavuconazole as sole or predominant antifungal therapy for COVID-19-associated mucormycosis. A retrospective observational case series.
Topics: Antifungal Agents; COVID-19; COVID-19 Drug Treatment; Humans; Mucormycosis; Nitriles; Pyridines; Retrospective Studies; Triazoles | 2022 |
Exposure to intravenous posaconazole in critically ill patients with influenza: A pharmacokinetic analysis of the POSA-FLU study.
Topics: Administration, Intravenous; Antifungal Agents; Critical Illness; Humans; Influenza, Human; Triazoles | 2022 |
Posaconazole oral suspension for secondary antifungal prophylaxis in allogeneic stem cell transplantation recipients: a retrospective study.
Topics: Antifungal Agents; Hematopoietic Stem Cell Transplantation; Humans; Invasive Fungal Infections; Retrospective Studies; Triazoles | 2022 |
Repurposing Lansoprazole and Posaconazole to treat leishmaniasis: Integration of in vitro testing, pharmacological corroboration, and mechanisms of action.
Topics: Antiprotozoal Agents; Drug Repositioning; Humans; In Vitro Techniques; Lansoprazole; Leishmania; Leishmaniasis; Triazoles | 2022 |
Cost-Effectiveness of Posaconazole vs. First-Generation Triazoles for the Prevention of Invasive Fungal Infections Among High-Risk Patients With Hematological Malignancies in China.
Topics: Antifungal Agents; Cost-Benefit Analysis; Hematologic Neoplasms; Humans; Invasive Fungal Infections; Mycoses; Tablets; Triazoles | 2022 |
Real-world effectiveness of antifungal prophylaxis with posaconazole as the primary agent in patients with haematological malignancies.
Topics: Adult; Antifungal Agents; Hematologic Neoplasms; Humans; Leukemia, Myeloid, Acute; Retrospective Studies; Triazoles | 2022 |
Biopredictive capability assessment of two dissolution/permeation assays, µFLUX™ and PermeaLoop™, using supersaturating formulations of Posaconazole.
Topics: Administration, Oral; Solubility; Tablets; Triazoles | 2022 |
Neuropharmacological Study of Posaconazole for Glioblastoma: A Phase 0 Clinical Trial Protocol.
Topics: Animals; Brain Neoplasms; Dialysis Solutions; Glioblastoma; Hexokinase; Lactates; Mice; Pyruvates; Triazoles | 2022 |
Acquisition of cross-azole tolerance and aneuploidy in Candida albicans strains evolved to posaconazole.
Topics: Aneuploidy; Antifungal Agents; Azoles; Candida albicans; Drug Resistance, Fungal; Fluconazole; Microbial Sensitivity Tests; Triazoles | 2022 |
Safe administration and pharmacokinetic monitoring of crushed venetoclax tablets with posaconazole and clarithromycin via percutaneous endoscopic gastrostomy tube in a patient with acute myeloid leukemia.
Topics: Bridged Bicyclo Compounds, Heterocyclic; Clarithromycin; Gastrostomy; Humans; Leukemia, Myeloid, Acute; Sulfonamides; Tablets; Triazoles | 2022 |
Antifungal prophylactic effectiveness and intrapulmonary concentrations of voriconazole versus posaconazole in lung transplant recipients.
Topics: Animals; Antifungal Agents; Humans; Invasive Fungal Infections; Lung; Retrospective Studies; Transplant Recipients; Triazoles; Voriconazole | 2022 |
Population pharmacokinetics of posaconazole in Chinese pediatric patients with acute leukaemia: Effect of food on bioavailability and dose optimization.
Topics: Acute Disease; Administration, Oral; Antifungal Agents; Biological Availability; Child; China; Diet, High-Fat; Humans; Leukemia, Myeloid, Acute; Prospective Studies; Triazoles | 2022 |
Effect of posaconazole on the concentration of intravenous and oral cyclosporine in patients undergoing hematopoietic stem cell transplantation.
Topics: Administration, Intravenous; Administration, Oral; Cyclosporine; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Retrospective Studies; Triazoles | 2022 |
Factors associated with subtherapeutic levels of oral posaconazole tablet: a detailed analysis from a tertiary care center in India.
Topics: Administration, Oral; Antifungal Agents; Diarrhea; Humans; Proton Pump Inhibitors; Retrospective Studies; Tablets; Tertiary Care Centers; Triazoles | 2022 |
Model-Informed Dose Justifications of Posaconazole in Japanese Patients for Prophylaxis and Treatment Against Fungal Infection.
Topics: Administration, Oral; Antifungal Agents; East Asian People; Humans; Mycoses; Tablets; Triazoles | 2023 |
DNA binding studies of antifungal drug posaconazole using spectroscopic and molecular docking methods.
Topics: Antifungal Agents; Circular Dichroism; DNA; Molecular Docking Simulation; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Thermodynamics; Triazoles | 2023 |
Effect of Isavuconazonium Sulfate and Posaconazole Delayed Release Tablets on Tacrolimus Dose-to-Concentration Ratios.
Topics: Antifungal Agents; Humans; Tablets; Tacrolimus; Triazoles | 2023 |
Therapeutic drug monitoring following crushed administration of delayed-release posaconazole tablets via enteral feeding tubes.
Topics: Administration, Oral; Drug Monitoring; Enteral Nutrition; Tablets; Triazoles | 2023 |
An Integrated Population Pharmacokinetic Analysis for Posaconazole Oral Suspension, Delayed-Release Tablet, and Intravenous Infusion in Healthy Volunteers.
Topics: Administration, Oral; Antifungal Agents; Biological Availability; Cross-Over Studies; Healthy Volunteers; Humans; Infusions, Intravenous; Suspensions; Tablets; Triazoles | 2023 |
Population Pharmacokinetics of Posaconazole in Immune-Compromised Children and Assessment of Target Attainment in Invasive Fungal Disease.
Topics: Administration, Oral; Adult; Antifungal Agents; Child; Humans; Invasive Fungal Infections; Retrospective Studies; Suspensions; Tablets; Triazoles | 2023 |
Comparative study of posaconazole and voriconazole for primary antifungal prophylaxis in patients with pediatric acute leukemia.
Topics: Antifungal Agents; Child; Humans; Invasive Fungal Infections; Leukemia, Myeloid, Acute; Retrospective Studies; Triazoles; Voriconazole | 2023 |
Triazole Antifungal Quantification for Therapeutic Drug Monitoring in Serum by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS): Posaconazole, Voriconazole, Itraconazole, and Hydroxyitraconazole.
Topics: Antifungal Agents; Chromatography, High Pressure Liquid; Chromatography, Liquid; Drug Monitoring; Itraconazole; Methanol; Reproducibility of Results; Tandem Mass Spectrometry; Triazoles; Voriconazole | 2024 |